locus-tag	class	description
M1S28_00010	COG0592	DNA-directed DNA polymerase activity
M1S28_00020	COG0187	DNA topoisomerase II activity
M1S28_00030	COG0586	Pfam SNARE associated Golgi protein
M1S28_00035	COG0488	(ABC) transporter
M1S28_00060	COG0596	Alpha beta hydrolase
M1S28_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S28_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S28_00110	COG0733	neurotransmitter:sodium symporter activity
M1S28_00150	COG2233	PERMEase
M1S28_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S28_00200	COG2814	Major facilitator Superfamily
M1S28_00205	COG0656	L-ascorbic acid biosynthetic process
M1S28_00210	COG0583	DNA-binding transcription factor activity
M1S28_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S28_00230	COG1064	alcohol dehydrogenase
M1S28_00235	COG2818	Glycosylase
M1S28_00250	COG1194	a g-specific adenine glycosylase
M1S28_00270	COG2983	Belongs to the UPF0260 family
M1S28_00275	COG2133	pyrroloquinoline quinone binding
M1S28_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S28_00285	COG2116	formate transmembrane transporter activity
M1S28_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S28_00310	COG1335	isochorismatase
M1S28_00315	COG0385	Bile acid
M1S28_00320	COG0534	Mate efflux family protein
M1S28_00325	COG1683	Conserved Protein
M1S28_00345	COG0625	glutathione transferase activity
M1S28_00355	COG1113	amino acid transport
M1S28_00365	COG0523	cobalamin synthesis protein
M1S28_00375	COG2188	Transcriptional regulator
M1S28_00405	COG0010	Belongs to the arginase family
M1S28_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S28_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S28_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S28_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S28_00540	COG0534	Mate efflux family protein
M1S28_00545	COG0436	Aminotransferase
M1S28_00550	COG2733	membrane
M1S28_00565	COG2918	glutathione biosynthetic process
M1S28_00580	COG1388	LysM domain
M1S28_00580	COG0791	NLP P60 protein
M1S28_00595	COG3150	esterase
M1S28_00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S28_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S28_00630	COG2233	PERMEase
M1S28_00635	COG2351	hydroxyisourate hydrolase activity
M1S28_00670	COG3706	GGDEF domain
M1S28_00685	COG1393	Belongs to the ArsC family
M1S28_00690	COG0708	Exodeoxyribonuclease III
M1S28_00710	COG0189	ligase activity
M1S28_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S28_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S28_00755	COG4942	peptidase
M1S28_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S28_00775	COG2119	membrane
M1S28_00780	COG4774	siderophore transport
M1S28_00785	COG0426	domain, Protein
M1S28_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S28_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S28_00830	COG1902	pentaerythritol trinitrate reductase activity
M1S28_00835	COG1519	Transferase
M1S28_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S28_00845	COG0668	transmembrane transport
M1S28_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S28_00860	COG1335	isochorismatase
M1S28_00865	COG1522	sequence-specific DNA binding
M1S28_00870	COG3328	transposase activity
M1S28_00895	COG2198	Histidine kinase
M1S28_00895	COG2205	protein histidine kinase activity
M1S28_00895	COG0784	Response regulator, receiver
M1S28_00900	COG3162	membrane
M1S28_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S28_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S28_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S28_00940	COG1309	transcriptional regulator
M1S28_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S28_00960	COG0352	thiamine-phosphate diphosphorylase activity
M1S28_00960	COG0351	phosphomethylpyrimidine kinase
M1S28_00970	COG2814	Major facilitator Superfamily
M1S28_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S28_00995	COG1113	amino acid transport
M1S28_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S28_01010	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_01020	COG1335	isochorismatase
M1S28_01050	COG2814	Major facilitator Superfamily
M1S28_01055	COG0583	DNA-binding transcription factor activity
M1S28_01075	COG0667	Aldo Keto reductase
M1S28_01110	COG1733	regulation of RNA biosynthetic process
M1S28_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S28_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S28_01195	COG2329	Antibiotic biosynthesis monooxygenase
M1S28_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S28_01255	COG0427	acetyl-CoA hydrolase
M1S28_01280	COG0659	secondary active sulfate transmembrane transporter activity
M1S28_01285	COG4221	oxidoreductase activity
M1S28_01290	COG2873	o-acetylhomoserine
M1S28_01295	COG0488	(ABC) transporter
M1S28_01380	COG0833	amino acid
M1S28_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S28_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S28_01445	COG2226	methyltransferase
M1S28_01495	COG0067	glutamate synthase
M1S28_01495	COG0069	glutamate synthase activity
M1S28_01495	COG0070	glutamate synthase
M1S28_01500	COG0493	'glutamate synthase
M1S28_01510	COG1704	LemA family
M1S28_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S28_01535	COG3307	-O-antigen
M1S28_01560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S28_01575	COG0194	GDP metabolic process
M1S28_01625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S28_01645	COG5380	lipid catabolic process
M1S28_01650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S28_01675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S28_01680	COG0277	FAD linked oxidase domain protein
M1S28_01690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S28_01695	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S28_01710	COG1289	transmembrane transporter activity
M1S28_01720	COG0628	permease
M1S28_01725	COG1192	Involved in chromosome partitioning
M1S28_01755	COG0833	amino acid
M1S28_01760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S28_01765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S28_01775	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_01815	COG0583	DNA-binding transcription factor activity
M1S28_01860	COG0517	IMP dehydrogenase activity
M1S28_01865	COG1983	PspC domain protein
M1S28_01875	COG1960	acyl-CoA dehydrogenase activity
M1S28_01890	COG0408	coproporphyrinogen oxidase activity
M1S28_01910	COG0513	Belongs to the DEAD box helicase family
M1S28_01920	COG1127	ABC transporter
M1S28_01925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S28_01935	COG2854	intermembrane phospholipid transfer
M1S28_01945	COG0598	Magnesium transport protein CorA
M1S28_01955	COG0494	nUDIX hydrolase
M1S28_01960	COG1040	competence protein
M1S28_01965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S28_01985	COG1946	Acyl-CoA thioesterase
M1S28_01990	COG1301	dicarboxylic acid transport
M1S28_02005	COG1959	2 iron, 2 sulfur cluster binding
M1S28_02010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S28_02010	COG1017	nitric oxide dioxygenase activity
M1S28_02015	COG0433	COG0433 Predicted ATPase
M1S28_02020	COG0626	cystathionine gamma-synthase activity
M1S28_02175	COG1960	acyl-CoA dehydrogenase activity
M1S28_02180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S28_02210	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S28_02215	COG0339	signal peptide processing
M1S28_02220	COG0557	exoribonuclease II activity
M1S28_02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S28_02265	COG2169	Transcriptional regulator
M1S28_02270	COG0697	spore germination
M1S28_02275	COG1295	ribonuclease BN
M1S28_02310	COG1702	phosphate starvation-inducible protein PhoH
M1S28_02320	COG0739	heme binding
M1S28_02320	COG0741	lytic transglycosylase activity
M1S28_02320	COG1196	nuclear chromosome segregation
M1S28_02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S28_02355	COG1183	phosphatidylcholine synthase activity
M1S28_02400	COG1960	acyl-CoA dehydrogenase activity
M1S28_02405	COG1309	transcriptional regulator
M1S28_02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S28_02425	COG1960	acyl-CoA dehydrogenase activity
M1S28_02445	COG2969	positive regulation of protein catabolic process
M1S28_02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S28_02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S28_02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S28_02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S28_02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S28_02510	COG1408	metallophosphoesterase
M1S28_02520	COG2199	diguanylate cyclase activity
M1S28_02580	COG1607	acyl-coa hydrolase
M1S28_02610	COG2350	Protein conserved in bacteria
M1S28_02620	COG0613	PHP domain protein
M1S28_02625	COG3781	membrane
M1S28_02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S28_02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S28_02650	COG1862	Preprotein translocase
M1S28_02680	COG2205	protein histidine kinase activity
M1S28_02685	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S28_02705	COG0726	polysaccharide deacetylase
M1S28_02710	COG0463	Glycosyl transferase, family 2
M1S28_02715	COG0438	transferase activity, transferring glycosyl groups
M1S28_02780	COG0625	glutathione transferase activity
M1S28_02785	COG0583	DNA-binding transcription factor activity
M1S28_02790	COG1960	acyl-CoA dehydrogenase activity
M1S28_02795	COG1960	acyl-CoA dehydrogenase activity
M1S28_02805	COG2205	protein histidine kinase activity
M1S28_02810	COG0745	RESPONSE REGULATOR receiver
M1S28_02815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S28_02835	COG2096	Adenosyltransferase
M1S28_02885	COG0285	dihydrofolate synthase activity
M1S28_02905	COG0450	alkyl hydroperoxide reductase
M1S28_02920	COG0477	Major facilitator Superfamily
M1S28_02925	COG1272	protein, Hemolysin III
M1S28_02955	COG0183	Belongs to the thiolase family
M1S28_02960	COG2207	Transcriptional regulator
M1S28_02980	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S28_03000	COG0183	Belongs to the thiolase family
M1S28_03010	COG2885	chlorophyll binding
M1S28_03010	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S28_03020	COG1690	Belongs to the RtcB family
M1S28_03025	COG0833	amino acid
M1S28_03035	COG2233	PERMEase
M1S28_03040	COG1217	gtp-binding protein TYPA
M1S28_03065	COG2094	Belongs to the DNA glycosylase MPG family
M1S28_03085	COG1902	pentaerythritol trinitrate reductase activity
M1S28_03100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S28_03105	COG0354	folic acid binding
M1S28_03115	COG3189	MarR family transcriptional regulator
M1S28_03120	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S28_03125	COG3422	double-strand break repair
M1S28_03165	COG0840	transmembrane signaling receptor activity
M1S28_03185	COG5510	response to toxic substance
M1S28_03195	COG2832	Protein of unknown function (DUF454)
M1S28_03200	COG1376	ErfK ybiS ycfS ynhG family protein
M1S28_03240	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S28_03250	COG1289	transmembrane transporter activity
M1S28_03255	COG2814	Major facilitator Superfamily
M1S28_03275	COG1115	amino acid carrier protein
M1S28_03280	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S28_03285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S28_03290	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S28_03320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S28_03330	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S28_03335	COG1077	Cell shape determining protein MreB Mrl
M1S28_03340	COG1792	Involved in formation and maintenance of cell shape
M1S28_03345	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S28_03350	COG0424	maF-like protein
M1S28_03355	COG1530	ribonuclease E activity
M1S28_03365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S28_03375	COG0560	Phosphoserine phosphatase
M1S28_03385	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S28_03410	COG2207	Transcriptional regulator
M1S28_03430	COG1113	amino acid transport
M1S28_03435	COG2828	Protein conserved in bacteria
M1S28_03440	COG0142	geranyltranstransferase activity
M1S28_03445	COG2315	Protein conserved in bacteria
M1S28_03460	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S28_03480	COG2194	sulfuric ester hydrolase activity
M1S28_03485	COG0745	RESPONSE REGULATOR receiver
M1S28_03490	COG0642	Histidine kinase
M1S28_03500	COG0004	ammonium transporteR
M1S28_03505	COG0583	DNA-binding transcription factor activity
M1S28_03525	COG0525	valine-tRNA ligase activity
M1S28_03535	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_03545	COG0393	Putative heavy-metal-binding
M1S28_03550	COG0393	Putative heavy-metal-binding
M1S28_03555	COG1538	Outer membrane efflux protein
M1S28_03565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S28_03570	COG0671	phosphoesterase, PA-phosphatase related
M1S28_03600	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S28_03615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S28_03615	COG1648	precorrin-2 dehydrogenase activity
M1S28_03620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S28_03625	COG1733	regulation of RNA biosynthetic process
M1S28_03635	COG0531	amino acid
M1S28_03650	COG0321	lipoyl(octanoyl) transferase activity
M1S28_03655	COG2921	Belongs to the UPF0250 family
M1S28_03695	COG2009	succinate dehydrogenase
M1S28_03700	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S28_03705	COG1053	succinate dehydrogenase
M1S28_03710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S28_03735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S28_03755	COG2354	Protein conserved in bacteria
M1S28_03760	COG2321	neutral zinc metallopeptidase
M1S28_03780	COG2843	Capsule synthesis protein
M1S28_03795	COG0589	response to stress
M1S28_03815	COG0505	Belongs to the CarA family
M1S28_03840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S28_03845	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S28_03895	COG0477	Major facilitator Superfamily
M1S28_03900	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S28_03915	COG1597	lipid kinase activity
M1S28_03920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S28_03950	COG0584	glycerophosphoryl diester phosphodiesterase
M1S28_03970	COG0741	lytic transglycosylase activity
M1S28_03990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S28_04005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S28_04035	COG0778	Nitroreductase
M1S28_04050	COG1929	Belongs to the glycerate kinase type-1 family
M1S28_04055	COG0243	molybdopterin cofactor binding
M1S28_04060	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S28_04065	COG3339	Conserved Protein
M1S28_04075	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S28_04090	COG1113	amino acid transport
M1S28_04100	COG0019	diaminopimelate decarboxylase activity
M1S28_04110	COG1280	lysine exporter protein (LysE YggA)
M1S28_04115	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S28_04145	COG0463	Glycosyl transferase, family 2
M1S28_04165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S28_04200	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S28_04205	COG1136	(ABC) transporter
M1S28_04210	COG0658	competence protein
M1S28_04210	COG2333	competence protein COMEC
M1S28_04220	COG0616	signal peptide processing
M1S28_04220	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S28_04225	COG0596	Alpha beta hydrolase
M1S28_04240	COG0628	permease
M1S28_04275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S28_04295	COG0823	Involved in the tonB-independent uptake of proteins
M1S28_04315	COG0824	Thioesterase
M1S28_04320	COG1473	amidohydrolase
M1S28_04340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S28_04340	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S28_04345	COG2814	Major facilitator Superfamily
M1S28_04355	COG1024	Enoyl-CoA hydratase
M1S28_04360	COG1051	belongs to the nudix hydrolase family
M1S28_04360	COG1056	cytidyltransferase-related domain
M1S28_04370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S28_04385	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S28_04400	COG4625	pathogenesis
M1S28_04405	COG0583	DNA-binding transcription factor activity
M1S28_04410	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S28_04415	COG4208	sulfate ABC transporter
M1S28_04420	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S28_04430	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S28_04435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S28_04440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S28_04460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S28_04475	COG0681	Belongs to the peptidase S26 family
M1S28_04490	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S28_04500	COG1381	Involved in DNA repair and RecF pathway recombination
M1S28_04505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S28_04515	COG4221	oxidoreductase activity
M1S28_04545	COG0436	Aminotransferase
M1S28_04565	COG0556	nucleotide-excision repair
M1S28_04620	COG2070	2-Nitropropane dioxygenase
M1S28_04650	COG1215	transferase activity, transferring glycosyl groups
M1S28_04665	COG0415	Belongs to the DNA photolyase family
M1S28_04675	COG1252	NADH dehydrogenase
M1S28_04680	COG1686	Belongs to the peptidase S11 family
M1S28_04695	COG1187	pseudouridine synthase activity
M1S28_04720	COG0477	Major facilitator Superfamily
M1S28_04725	COG0583	DNA-binding transcription factor activity
M1S28_04730	COG1823	symporter activity
M1S28_04740	COG0612	Peptidase, M16
M1S28_04765	COG0352	thiamine-phosphate diphosphorylase activity
M1S28_04800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S28_04815	COG1309	transcriptional regulator
M1S28_04825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S28_04830	COG0076	glutamate decarboxylase activity
M1S28_04840	COG1522	sequence-specific DNA binding
M1S28_04845	COG3961	Belongs to the TPP enzyme family
M1S28_04850	COG1113	amino acid transport
M1S28_04855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S28_04860	COG0573	inorganic phosphate transmembrane transporter activity
M1S28_04870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S28_04875	COG0616	signal peptide processing
M1S28_04910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S28_04915	COG1686	Belongs to the peptidase S11 family
M1S28_04940	COG0583	DNA-binding transcription factor activity
M1S28_04945	COG1067	ATP-dependent peptidase activity
M1S28_04990	COG1966	Carbon starvation protein
M1S28_04995	COG2879	small protein
M1S28_05030	COG2508	Transcriptional regulator
M1S28_05030	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S28_05050	COG1113	amino acid transport
M1S28_05055	COG0583	DNA-binding transcription factor activity
M1S28_05060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S28_05065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S28_05075	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_05085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S28_05090	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S28_05090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S28_05125	COG2814	Major facilitator Superfamily
M1S28_05130	COG4948	Mandelate Racemase Muconate Lactonizing
M1S28_05140	COG1309	transcriptional regulator
M1S28_05160	COG1741	Belongs to the pirin family
M1S28_05170	COG2964	Protein conserved in bacteria
M1S28_05185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S28_05190	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S28_05195	COG4605	iron ion homeostasis
M1S28_05200	COG4604	ABC transporter, ATP-binding protein
M1S28_05205	COG4607	ABC-type enterochelin transport system periplasmic component
M1S28_05210	COG4774	siderophore transport
M1S28_05220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S28_05225	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S28_05230	COG1535	isochorismatase
M1S28_05230	COG3433	isochorismatase activity
M1S28_05245	COG1132	(ABC) transporter
M1S28_05250	COG1132	(ABC) transporter
M1S28_05255	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S28_05265	COG1169	isochorismate synthase
M1S28_05280	COG3739	integral membrane protein
M1S28_05305	COG0302	gtp cyclohydrolase
M1S28_05315	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S28_05345	COG0308	aminopeptidase N
M1S28_05350	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S28_05365	COG0174	glutamine synthetase
M1S28_05375	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S28_05410	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S28_05415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S28_05420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S28_05440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S28_05445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S28_05450	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S28_05465	COG1960	acyl-CoA dehydrogenase activity
M1S28_05470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S28_05475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S28_05485	COG2223	nitrite transmembrane transporter activity
M1S28_05495	COG0024	Methionine aminopeptidase
M1S28_05500	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S28_05515	COG2207	Transcriptional regulator
M1S28_05540	COG2951	lytic endotransglycosylase activity
M1S28_05545	COG0772	Belongs to the SEDS family
M1S28_05560	COG0842	Transport permease protein
M1S28_05565	COG1131	(ABC) transporter
M1S28_05610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S28_05625	COG4215	(ABC) transporter
M1S28_05630	COG4160	amino acid transport
M1S28_05635	COG4598	ABC transporter
M1S28_05645	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S28_05650	COG0826	peptidase U32
M1S28_05655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S28_05670	COG1720	tRNA m6t6A37 methyltransferase activity
M1S28_05680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S28_05695	COG0642	Histidine kinase
M1S28_05705	COG0494	nUDIX hydrolase
M1S28_05715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S28_05720	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S28_05725	COG3139	Protein of unknown function (DUF1315)
M1S28_05730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S28_05735	COG1301	dicarboxylic acid transport
M1S28_05740	COG1960	acyl-CoA dehydrogenase activity
M1S28_05745	COG2819	hydrolase of the alpha beta superfamily
M1S28_05755	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S28_05765	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S28_05770	COG1234	tRNA 3'-trailer cleavage
M1S28_05800	COG2363	Small membrane protein
M1S28_05825	COG0513	Belongs to the DEAD box helicase family
M1S28_05835	COG0778	Nitroreductase
M1S28_06190	COG1286	toxin biosynthetic process
M1S28_06215	COG4783	chaperone-mediated protein folding
M1S28_06220	COG1610	YqeY-like protein
M1S28_06320	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S28_06345	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S28_06350	COG0786	glutamate:sodium symporter activity
M1S28_06360	COG2186	Transcriptional regulator
M1S28_06470	COG0488	(ABC) transporter
M1S28_06475	COG3173	Aminoglycoside phosphotransferase
M1S28_06485	COG2433	Pfam Transposase IS66
M1S28_06500	COG3038	cytochrome b561
M1S28_06520	COG2267	carboxylic ester hydrolase activity
M1S28_06525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S28_06530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S28_06535	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_06545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S28_06555	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_06560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S28_06565	COG0583	DNA-binding transcription factor activity
M1S28_06575	COG1414	Transcriptional regulator
M1S28_06580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S28_06590	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S28_06595	COG3842	ATPase activity
M1S28_06610	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S28_06615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S28_06620	COG2814	Major facilitator Superfamily
M1S28_06625	COG1960	acyl-CoA dehydrogenase activity
M1S28_06640	COG1024	Enoyl-CoA hydratase
M1S28_06650	COG2814	Major facilitator Superfamily
M1S28_06660	COG0183	Belongs to the thiolase family
M1S28_06665	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S28_06670	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_06675	COG1024	Enoyl-CoA hydratase
M1S28_06680	COG1960	acyl-CoA dehydrogenase activity
M1S28_06685	COG2814	Major facilitator Superfamily
M1S28_06690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S28_06695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S28_06705	COG2814	Major facilitator Superfamily
M1S28_06715	COG1960	acyl-CoA dehydrogenase activity
M1S28_06730	COG0583	DNA-binding transcription factor activity
M1S28_06740	COG4770	biotin carboxylase activity
M1S28_06745	COG1024	Enoyl-CoA hydratase
M1S28_06750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S28_06755	COG1960	acyl-CoA dehydrogenase activity
M1S28_06760	COG1309	transcriptional regulator
M1S28_06765	COG0318	PFAM AMP-dependent synthetase and ligase
M1S28_06790	COG0583	DNA-binding transcription factor activity
M1S28_06840	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_06860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S28_06880	COG2205	protein histidine kinase activity
M1S28_06880	COG0784	Response regulator, receiver
M1S28_06900	COG0765	amino acid transport
M1S28_06905	COG0765	amino acid transport
M1S28_06910	COG1126	abc transporter atp-binding protein
M1S28_06915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S28_06920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S28_06935	COG1280	lysine exporter protein (LysE YggA)
M1S28_06945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S28_06950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S28_06955	COG1045	serine acetyltransferase
M1S28_06970	COG0583	DNA-binding transcription factor activity
M1S28_06975	COG0625	glutathione transferase activity
M1S28_06980	COG0625	glutathione transferase activity
M1S28_06985	COG0583	DNA-binding transcription factor activity
M1S28_06995	COG1346	cytolysis
M1S28_07015	COG2814	Major facilitator Superfamily
M1S28_07025	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S28_07030	COG3052	prosthetic group binding
M1S28_07050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S28_07070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S28_07080	COG1294	oxidase, subunit
M1S28_07085	COG1271	oxidase subunit
M1S28_07105	COG0477	Major facilitator Superfamily
M1S28_07115	COG4521	taurine ABC transporter
M1S28_07120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S28_07125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S28_07130	COG2175	clavaminate synthase activity
M1S28_07140	COG1953	Uracil, thiamine, allantoin
M1S28_07150	COG0583	DNA-binding transcription factor activity
M1S28_07160	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S28_07175	COG0640	Transcriptional regulator
M1S28_07180	COG0798	PFAM Bile acid sodium symporter
M1S28_07185	COG0583	DNA-binding transcription factor activity
M1S28_07200	COG3634	alkyl hydroperoxide reductase activity
M1S28_07240	COG0436	Aminotransferase
M1S28_07250	COG0386	Belongs to the glutathione peroxidase family
M1S28_07290	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S28_07315	COG0012	GTP binding
M1S28_07320	COG2011	ABC-type metal ion transport system permease component
M1S28_07345	COG1464	Belongs to the NlpA lipoprotein family
M1S28_07375	COG0765	amino acid transport
M1S28_07380	COG0765	amino acid transport
M1S28_07385	COG1126	abc transporter atp-binding protein
M1S28_07400	COG1522	sequence-specific DNA binding
M1S28_07415	COG1309	transcriptional regulator
M1S28_07435	COG0583	DNA-binding transcription factor activity
M1S28_07445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S28_07455	COG0697	spore germination
M1S28_07480	COG3121	Chaperone
M1S28_07485	COG3539	Fimbrial protein
M1S28_07510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S28_07510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S28_07555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S28_07565	COG2353	YceI-like domain
M1S28_07575	COG3698	Phosphodiester glycosidase
M1S28_07590	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S28_07595	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S28_07595	COG0506	proline dehydrogenase activity
M1S28_07595	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S28_07605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S28_07610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S28_07630	COG1132	(ABC) transporter
M1S28_07635	COG3122	Protein conserved in bacteria
M1S28_07640	COG3619	membrane
M1S28_07650	COG0640	Transcriptional regulator
M1S28_07660	COG2850	peptidyl-arginine hydroxylation
M1S28_07665	COG0424	maF-like protein
M1S28_07685	COG0191	fructose-bisphosphate aldolase activity
M1S28_07690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S28_07705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S28_07715	COG1192	Involved in chromosome partitioning
M1S28_07720	COG1475	DNA binding
M1S28_07725	COG0811	peptide transport
M1S28_07735	COG1132	(ABC) transporter
M1S28_07740	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S28_07760	COG0084	hydrolase, TatD family'
M1S28_07825	COG0776	regulation of translation
M1S28_07855	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S28_07860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S28_07910	COG0339	signal peptide processing
M1S28_07920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S28_07955	COG0702	epimerase
M1S28_07960	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S28_07990	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S28_08020	COG0316	Belongs to the HesB IscA family
M1S28_08025	COG0822	iron-sulfur transferase activity
M1S28_08050	COG0776	regulation of translation
M1S28_08055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S28_08060	COG2207	Transcriptional regulator
M1S28_08065	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S28_08070	COG1960	acyl-CoA dehydrogenase activity
M1S28_08075	COG1960	acyl-CoA dehydrogenase activity
M1S28_08090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S28_08110	COG4264	IucA IucC family
M1S28_08115	COG4264	IucA IucC family
M1S28_08155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S28_08170	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S28_08190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S28_08195	COG0730	response to heat
M1S28_08215	COG4773	Receptor
M1S28_08220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S28_08235	COG1131	(ABC) transporter
M1S28_08240	COG0842	Transport permease protein
M1S28_08245	COG0842	Transport permease protein
M1S28_08300	COG2226	methyltransferase
M1S28_08325	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S28_08360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S28_08370	COG0133	tryptophan synthase activity
M1S28_08385	COG3706	GGDEF domain
M1S28_08400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S28_08405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S28_08410	COG0022	dehydrogenase e1 component
M1S28_08415	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S28_08420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S28_08430	COG1063	alcohol dehydrogenase
M1S28_08435	COG3781	membrane
M1S28_08445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S28_08445	COG3453	Protein conserved in bacteria
M1S28_08460	COG0730	response to heat
M1S28_08475	COG2207	Transcriptional regulator
M1S28_08475	COG3708	Transcriptional regulator
M1S28_08480	COG1733	regulation of RNA biosynthetic process
M1S28_08485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S28_08495	COG2188	Transcriptional regulator
M1S28_08510	COG4521	taurine ABC transporter
M1S28_08515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S28_08535	COG0477	Major facilitator Superfamily
M1S28_08545	COG1027	Aspartate ammonia-lyase
M1S28_08560	COG0583	DNA-binding transcription factor activity
M1S28_08565	COG0583	DNA-binding transcription factor activity
M1S28_08570	COG0183	Belongs to the thiolase family
M1S28_08575	COG2031	fatty acid transporter
M1S28_08580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S28_08590	COG0583	DNA-binding transcription factor activity
M1S28_08600	COG2610	gluconate transmembrane transporter activity
M1S28_08605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_08615	COG2207	Transcriptional regulator
M1S28_08630	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_08655	COG0543	2 iron, 2 sulfur cluster binding
M1S28_08655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S28_08660	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S28_08665	COG4638	Rieske (2fe-2S)
M1S28_08675	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S28_08680	COG4149	molybdate abc transporter
M1S28_08685	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S28_08690	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_08695	COG3433	isochorismatase activity
M1S28_08695	COG1535	isochorismatase
M1S28_08755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S28_08770	COG0753	catalase activity
M1S28_08780	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S28_08810	COG3539	Fimbrial protein
M1S28_08830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S28_08850	COG2072	flavoprotein involved in K transport
M1S28_08860	COG1538	Outer membrane efflux protein
M1S28_08865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S28_08870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S28_08875	COG0745	RESPONSE REGULATOR receiver
M1S28_08880	COG2205	protein histidine kinase activity
M1S28_08895	COG2207	Transcriptional regulator
M1S28_08910	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_08960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S28_09080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S28_09100	COG1120	ATPase activity
M1S28_09105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S28_09115	COG1064	alcohol dehydrogenase
M1S28_09130	COG2207	Transcriptional regulator
M1S28_09135	COG2084	Dehydrogenase
M1S28_09145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S28_09155	COG0583	DNA-binding transcription factor activity
M1S28_09165	COG0129	dihydroxy-acid dehydratase activity
M1S28_09170	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_09185	COG1566	PFAM secretion protein HlyD family protein
M1S28_09220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S28_09250	COG0583	DNA-binding transcription factor activity
M1S28_09265	COG2188	Transcriptional regulator
M1S28_09295	COG3210	domain, Protein
M1S28_09300	COG2831	hemolysin activation secretion protein
M1S28_09310	COG1473	amidohydrolase
M1S28_09330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S28_09330	COG0475	glutathione-regulated potassium exporter activity
M1S28_09340	COG0583	DNA-binding transcription factor activity
M1S28_09345	COG1335	isochorismatase
M1S28_09355	COG1309	transcriptional regulator
M1S28_09385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S28_09395	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S28_09395	COG1902	pentaerythritol trinitrate reductase activity
M1S28_09400	COG1846	Transcriptional regulator
M1S28_09420	COG0753	catalase activity
M1S28_09435	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_09450	COG3162	membrane
M1S28_09460	COG3829	transcription factor binding
M1S28_09465	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_09470	COG1960	acyl-CoA dehydrogenase activity
M1S28_09490	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_09510	COG2186	Transcriptional regulator
M1S28_09520	COG0583	DNA-binding transcription factor activity
M1S28_09525	COG4948	Mandelate Racemase Muconate Lactonizing
M1S28_09530	COG4829	muconolactone delta-isomerase
M1S28_09540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S28_09545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S28_09550	COG0183	Belongs to the thiolase family
M1S28_09555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S28_09565	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_09575	COG3733	amine oxidase
M1S28_09585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S28_09595	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_09605	COG4638	Rieske (2fe-2S)
M1S28_09625	COG0154	amidase activity
M1S28_09635	COG2814	Major facilitator Superfamily
M1S28_09660	COG1960	acyl-CoA dehydrogenase activity
M1S28_09665	COG0583	DNA-binding transcription factor activity
M1S28_09670	COG1414	Transcriptional regulator
M1S28_09685	COG2391	methyltransferase activity
M1S28_09695	COG4993	Dehydrogenase
M1S28_09700	COG3659	wide pore channel activity
M1S28_09705	COG3420	alginic acid biosynthetic process
M1S28_09710	COG0710	3-dehydroquinate dehydratase activity
M1S28_09715	COG3485	protocatechuate 3,4-dioxygenase
M1S28_09720	COG3485	protocatechuate 3,4-dioxygenase
M1S28_09725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S28_09730	COG2271	Major facilitator Superfamily
M1S28_09735	COG0596	Alpha beta hydrolase
M1S28_09740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S28_09745	COG0183	Belongs to the thiolase family
M1S28_09750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S28_09755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S28_09765	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S28_09770	COG2323	membrane
M1S28_09815	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S28_09815	COG1902	pentaerythritol trinitrate reductase activity
M1S28_09840	COG0542	response to heat
M1S28_09845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S28_09875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S28_09880	COG0569	domain protein
M1S28_09885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S28_09900	COG4774	siderophore transport
M1S28_09905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S28_09915	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S28_09930	COG1294	oxidase, subunit
M1S28_09935	COG4890	Cyd operon protein YbgT
M1S28_09950	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S28_09960	COG0552	protein localization to endoplasmic reticulum
M1S28_09985	COG0516	GMP reductase activity
M1S28_09985	COG0517	IMP dehydrogenase activity
M1S28_09990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S28_09995	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S28_10005	COG0583	DNA-binding transcription factor activity
M1S28_10010	COG0024	Methionine aminopeptidase
M1S28_10040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S28_10040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S28_10045	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S28_10050	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S28_10050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S28_10050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S28_10070	COG5001	Diguanylate cyclase
M1S28_10070	COG3300	MHYT domain
M1S28_10085	COG2135	peptidase activity
M1S28_10090	COG0659	secondary active sulfate transmembrane transporter activity
M1S28_10110	COG1113	amino acid transport
M1S28_10120	COG1522	sequence-specific DNA binding
M1S28_10145	COG1011	Hydrolase
M1S28_10150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S28_10160	COG2137	regulation of response to DNA damage stimulus
M1S28_10175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S28_10210	COG0575	Belongs to the CDS family
M1S28_10215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S28_10235	COG3852	Histidine kinase
M1S28_10240	COG2204	response regulator
M1S28_10305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S28_10310	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S28_10330	COG0697	spore germination
M1S28_10335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S28_10345	COG0303	'Molybdopterin
M1S28_10350	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S28_10350	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S28_10365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S28_10370	COG0243	molybdopterin cofactor binding
M1S28_10380	COG0243	molybdopterin cofactor binding
M1S28_10385	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S28_10390	COG2146	nitrite reductase [NAD(P)H] activity
M1S28_10390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S28_10400	COG0745	RESPONSE REGULATOR receiver
M1S28_10405	COG1116	anion transmembrane transporter activity
M1S28_10405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S28_10425	COG0511	ligase activity, forming carbon-carbon bonds
M1S28_10440	COG2814	Major facilitator Superfamily
M1S28_10510	COG0739	heme binding
M1S28_10630	COG5410	chromosome segregation
M1S28_10790	COG0069	glutamate synthase activity
M1S28_10810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S28_10820	COG1454	alcohol dehydrogenase
M1S28_10825	COG0824	Thioesterase
M1S28_10835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S28_10850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S28_10855	COG2030	dehydratase
M1S28_10865	COG0183	Belongs to the thiolase family
M1S28_10875	COG0583	DNA-binding transcription factor activity
M1S28_10880	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S28_10890	COG1522	sequence-specific DNA binding
M1S28_10895	COG3135	benzoate transporter
M1S28_10905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S28_10930	COG0589	response to stress
M1S28_10935	COG0488	(ABC) transporter
M1S28_10955	COG4773	Receptor
M1S28_10990	COG0668	transmembrane transport
M1S28_11000	COG1309	transcriptional regulator
M1S28_11020	COG1605	Chorismate mutase
M1S28_11030	COG4221	oxidoreductase activity
M1S28_11040	COG0308	aminopeptidase N
M1S28_11060	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S28_11070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S28_11075	COG1454	alcohol dehydrogenase
M1S28_11095	COG0531	amino acid
M1S28_11100	COG4303	Ethanolamine ammonia lyase large subunit
M1S28_11105	COG4302	ethanolamine ammonia-lyase activity
M1S28_11110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S28_11110	COG0519	Catalyzes the synthesis of GMP from XMP
M1S28_11115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S28_11125	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S28_11140	COG0697	spore germination
M1S28_11145	COG1923	regulation of RNA biosynthetic process
M1S28_11155	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S28_11160	COG0802	atpase or kinase
M1S28_11180	COG1187	pseudouridine synthase activity
M1S28_11195	COG0583	DNA-binding transcription factor activity
M1S28_11210	COG2814	Major facilitator Superfamily
M1S28_11215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S28_11240	COG0729	surface antigen
M1S28_11260	COG0174	glutamine synthetase
M1S28_11265	COG0745	RESPONSE REGULATOR receiver
M1S28_11270	COG2205	protein histidine kinase activity
M1S28_11280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S28_11285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S28_11310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S28_11315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S28_11320	COG1960	acyl-CoA dehydrogenase activity
M1S28_11335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S28_11340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S28_11360	COG0583	DNA-binding transcription factor activity
M1S28_11375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S28_11385	COG3658	cytochrome
M1S28_11390	COG1215	transferase activity, transferring glycosyl groups
M1S28_11395	COG0726	polysaccharide deacetylase
M1S28_11395	COG1649	PFAM Uncharacterised BCR, COG1649
M1S28_11420	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S28_11425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S28_11435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S28_11460	COG0305	Participates in initiation and elongation during chromosome replication
M1S28_11465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S28_11475	COG1305	Transglutaminase-like
M1S28_11485	COG2308	Evidence 4 Homologs of previously reported genes of
M1S28_11515	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S28_11520	COG0138	bifunctional purine biosynthesis protein purh
M1S28_11525	COG0151	Belongs to the GarS family
M1S28_11530	COG1464	Belongs to the NlpA lipoprotein family
M1S28_11535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S28_11540	COG2011	ABC-type metal ion transport system permease component
M1S28_11545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S28_11555	COG1301	dicarboxylic acid transport
M1S28_11585	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S28_11605	COG2814	Major facilitator Superfamily
M1S28_11620	COG1560	Kdo2-lipid A biosynthetic process
M1S28_11630	COG5006	permease, DMT superfamily
M1S28_11635	COG1522	sequence-specific DNA binding
M1S28_11650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S28_11660	COG4122	O-methyltransferase activity
M1S28_11690	COG1538	Outer membrane efflux protein
M1S28_11695	COG1137	ATPase activity
M1S28_11700	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S28_11710	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S28_11715	COG0517	IMP dehydrogenase activity
M1S28_11715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S28_11750	COG2814	Major facilitator Superfamily
M1S28_11785	COG1278	Cold shock
M1S28_11790	COG1280	lysine exporter protein (LysE YggA)
M1S28_11820	COG1570	exodeoxyribonuclease VII activity
M1S28_11870	COG0583	DNA-binding transcription factor activity
M1S28_11880	COG4638	Rieske (2fe-2S)
M1S28_11885	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S28_11890	COG0633	Ferredoxin
M1S28_11890	COG0543	2 iron, 2 sulfur cluster binding
M1S28_11895	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_11900	COG3135	benzoate transporter
M1S28_11905	COG2814	Major facilitator Superfamily
M1S28_11920	COG1643	Atp-dependent helicase
M1S28_11925	COG0450	alkyl hydroperoxide reductase
M1S28_11935	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S28_11945	COG3634	alkyl hydroperoxide reductase activity
M1S28_11965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S28_11970	COG0625	glutathione transferase activity
M1S28_11980	COG2885	chlorophyll binding
M1S28_12015	COG0542	response to heat
M1S28_12030	COG1765	OsmC-like protein
M1S28_12050	COG0667	Aldo Keto reductase
M1S28_12065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S28_12075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S28_12085	COG0527	aspartate kinase activity
M1S28_12095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S28_12105	COG3038	cytochrome b561
M1S28_12110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S28_12115	COG2252	PERMEase
M1S28_12125	COG2072	flavoprotein involved in K transport
M1S28_12140	COG1741	Belongs to the pirin family
M1S28_12145	COG1309	transcriptional regulator
M1S28_12155	COG0300	oxidoreductase activity
M1S28_12180	COG1113	amino acid transport
M1S28_12220	COG3209	COG3209 Rhs family protein
M1S28_12250	COG4269	membrane
M1S28_12265	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S28_12265	COG1902	pentaerythritol trinitrate reductase activity
M1S28_12275	COG5001	Diguanylate cyclase
M1S28_12275	COG4251	negative regulation of phosphorylation
M1S28_12275	COG3706	GGDEF domain
M1S28_12275	COG2203	Gaf domain
M1S28_12285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S28_12305	COG4172	Belongs to the ABC transporter superfamily
M1S28_12310	COG4239	(ABC) transporter, permease
M1S28_12315	COG4174	ABC transporter (Permease)
M1S28_12325	COG0741	lytic transglycosylase activity
M1S28_12325	COG1388	LysM domain
M1S28_12325	COG0741	lytic transglycosylase activity
M1S28_12325	COG1388	LysM domain
M1S28_12330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S28_12370	COG0583	DNA-binding transcription factor activity
M1S28_12375	COG1279	arginine transmembrane transporter activity
M1S28_12395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S28_12400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S28_12405	COG0006	proline dipeptidase activity
M1S28_12490	COG1196	nuclear chromosome segregation
M1S28_12490	COG0741	lytic transglycosylase activity
M1S28_12490	COG0739	heme binding
M1S28_12550	COG4695	Portal protein
M1S28_12650	COG0305	Participates in initiation and elongation during chromosome replication
M1S28_12665	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S28_12720	COG2194	sulfuric ester hydrolase activity
M1S28_12765	COG0739	heme binding
M1S28_13090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S28_13115	COG3384	dioxygenase
M1S28_13125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S28_13130	COG2878	Part of a membrane complex involved in electron transport
M1S28_13135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S28_13160	COG0768	penicillin binding
M1S28_13165	COG0742	ribosomal rna small subunit methyltransferase
M1S28_13180	COG0830	nickel cation binding
M1S28_13190	COG0804	urea catabolic process
M1S28_13230	COG1253	flavin adenine dinucleotide binding
M1S28_13235	COG2851	Citrate transporter
M1S28_13285	COG1773	rubredoxin
M1S28_13290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S28_13300	COG0583	DNA-binding transcription factor activity
M1S28_13325	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S28_13330	COG4181	ATPase activity
M1S28_13375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S28_13395	COG0306	phosphate transporter
M1S28_13405	COG3958	Transketolase
M1S28_13410	COG3959	Transketolase, thiamine diphosphate binding domain
M1S28_13415	COG2271	Major facilitator Superfamily
M1S28_13420	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_13425	COG0583	DNA-binding transcription factor activity
M1S28_13440	COG2223	nitrite transmembrane transporter activity
M1S28_13445	COG2207	Transcriptional regulator
M1S28_13450	COG2066	Belongs to the glutaminase family
M1S28_13455	COG0242	peptide deformylase activity
M1S28_13460	COG0477	Major facilitator Superfamily
M1S28_13470	COG0028	Belongs to the TPP enzyme family
M1S28_13485	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_13490	COG2267	carboxylic ester hydrolase activity
M1S28_13500	COG2271	Major facilitator Superfamily
M1S28_13505	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S28_13515	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_13535	COG1414	Transcriptional regulator
M1S28_13550	COG1024	Enoyl-CoA hydratase
M1S28_13560	COG1215	transferase activity, transferring glycosyl groups
M1S28_13565	COG1649	PFAM Uncharacterised BCR, COG1649
M1S28_13565	COG0726	polysaccharide deacetylase
M1S28_13575	COG4681	YaeQ
M1S28_13585	COG0523	cobalamin synthesis protein
M1S28_13595	COG1607	acyl-coa hydrolase
M1S28_13605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S28_13610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S28_13615	COG1309	transcriptional regulator
M1S28_13640	COG2040	homocysteine
M1S28_13645	COG0531	amino acid
M1S28_13700	COG1595	DNA-templated transcription, initiation
M1S28_13710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S28_13715	COG0477	Major facilitator Superfamily
M1S28_13735	COG0084	hydrolase, TatD family'
M1S28_13770	COG0629	single-stranded DNA binding
M1S28_13825	COG0582	viral genome integration into host DNA
M1S28_13915	COG0592	DNA-directed DNA polymerase activity
M1S28_13955	COG2026	Addiction module toxin, RelE StbE family
M1S28_14105	COG3755	Protein conserved in bacteria
M1S28_14150	COG1484	DNA-dependent DNA replication
M1S28_14240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S28_14310	COG0405	Gamma-glutamyltransferase
M1S28_14315	COG2814	Major facilitator Superfamily
M1S28_14325	COG2050	protein possibly involved in aromatic compounds catabolism
M1S28_14340	COG1090	epimerase
M1S28_14360	COG0420	3'-5' exonuclease activity
M1S28_14385	COG0735	belongs to the Fur family
M1S28_14390	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S28_14410	COG0121	glutamine amidotransferase
M1S28_14425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S28_14435	COG0210	DNA helicase
M1S28_14440	COG2885	chlorophyll binding
M1S28_14445	COG0204	Acyl-transferase
M1S28_14460	COG2894	cell division
M1S28_14480	COG1280	lysine exporter protein (LysE YggA)
M1S28_14485	COG1674	ftsk spoiiie
M1S28_14485	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S28_14490	COG0492	ferredoxin-NADP+ reductase activity
M1S28_14495	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S28_14505	COG0456	acetyltransferase
M1S28_14550	COG1981	membrane
M1S28_14565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S28_14565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S28_14585	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_14595	COG0657	acetylesterase activity
M1S28_14605	COG0473	3-isopropylmalate dehydrogenase activity
M1S28_14610	COG0583	DNA-binding transcription factor activity
M1S28_14630	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S28_14655	COG0564	pseudouridine synthase activity
M1S28_14665	COG0358	DNA primase activity
M1S28_14680	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S28_14710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S28_14740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S28_14750	COG0352	thiamine-phosphate diphosphorylase activity
M1S28_14750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S28_14750	COG0351	phosphomethylpyrimidine kinase
M1S28_14755	COG1652	LysM domain
M1S28_14780	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S28_14785	COG3101	peptidyl-lysine hydroxylation
M1S28_14790	COG0009	L-threonylcarbamoyladenylate synthase
M1S28_14795	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S28_14800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S28_14815	COG4106	trans-aconitate 2-methyltransferase activity
M1S28_14830	COG0596	Alpha beta hydrolase
M1S28_14830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S28_14830	COG2226	methyltransferase
M1S28_14835	COG1877	trehalose-phosphatase activity
M1S28_14840	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S28_14845	COG2223	nitrite transmembrane transporter activity
M1S28_14865	COG1196	nuclear chromosome segregation
M1S28_14875	COG0730	response to heat
M1S28_14890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S28_14900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S28_14960	COG0489	protein tyrosine kinase activity
M1S28_14970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S28_14970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S28_15000	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S28_15005	COG2081	HI0933 family
M1S28_15015	COG0668	transmembrane transport
M1S28_15035	COG0583	DNA-binding transcription factor activity
M1S28_15055	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S28_15060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S28_15090	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S28_15130	COG0745	RESPONSE REGULATOR receiver
M1S28_15150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S28_15160	COG2205	protein histidine kinase activity
M1S28_15230	COG4993	Dehydrogenase
M1S28_15255	COG0384	phenazine biosynthesis protein PhzF
M1S28_15280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S28_15295	COG0583	DNA-binding transcription factor activity
M1S28_15325	COG0583	DNA-binding transcription factor activity
M1S28_15340	COG0583	DNA-binding transcription factor activity
M1S28_15345	COG1053	succinate dehydrogenase
M1S28_15355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S28_15360	COG2814	Major facilitator Superfamily
M1S28_15365	COG1960	acyl-CoA dehydrogenase activity
M1S28_15370	COG0583	DNA-binding transcription factor activity
M1S28_15375	COG1063	alcohol dehydrogenase
M1S28_15405	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S28_15410	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S28_15415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S28_15430	COG3667	copper resistance
M1S28_15435	COG2132	Multicopper oxidase
M1S28_15445	COG0561	phosphatase activity
M1S28_15450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S28_15475	COG1214	PFAM Peptidase M22, glycoprotease
M1S28_15525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S28_15535	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S28_15540	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S28_15545	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S28_15605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S28_15615	COG1846	Transcriptional regulator
M1S28_15620	COG1764	response to oxidative stress
M1S28_15660	COG0037	tRNA processing
M1S28_15670	COG0248	Ppx GppA phosphatase
M1S28_15700	COG0072	phenylalanine-tRNA ligase activity
M1S28_15745	COG1238	metal cluster binding
M1S28_15750	COG0625	glutathione transferase activity
M1S28_15765	COG0318	PFAM AMP-dependent synthetase and ligase
M1S28_15770	COG3028	Belongs to the UPF0307 family
M1S28_15775	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S28_15795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S28_15800	COG0617	tRNA 3'-terminal CCA addition
M1S28_15805	COG1555	photosystem II stabilization
M1S28_15810	COG3956	TIGRFAM MazG family protein
M1S28_15820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S28_15840	COG0784	Response regulator, receiver
M1S28_15840	COG2205	protein histidine kinase activity
M1S28_15840	COG5002	protein histidine kinase activity
M1S28_15845	COG1024	Enoyl-CoA hydratase
M1S28_15850	COG2084	Dehydrogenase
M1S28_15855	COG3622	Belongs to the hyi family
M1S28_15885	COG0697	spore germination
M1S28_15895	COG2814	Major facilitator Superfamily
M1S28_15900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S28_15910	COG0583	DNA-binding transcription factor activity
M1S28_15920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S28_15935	COG0084	hydrolase, TatD family'
M1S28_15950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S28_15980	COG0440	acetolactate synthase activity
M1S28_15985	COG0028	Belongs to the TPP enzyme family
M1S28_16010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S28_16015	COG0577	efflux transmembrane transporter activity
M1S28_16015	COG1136	(ABC) transporter
M1S28_16020	COG1538	Outer membrane efflux protein
M1S28_16035	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S28_16040	COG1162	GTPase activity
M1S28_16050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S28_16070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S28_16075	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_16115	COG2986	histidine ammonia-lyase
M1S28_16130	COG0318	PFAM AMP-dependent synthetase and ligase
M1S28_16140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S28_16185	COG1426	Protein conserved in bacteria
M1S28_16220	COG0793	Belongs to the peptidase S41A family
M1S28_16235	COG2267	carboxylic ester hydrolase activity
M1S28_16245	COG1012	belongs to the aldehyde dehydrogenase family
M1S28_16250	COG3265	gluconokinase activity
M1S28_16260	COG0800	Aldolase
M1S28_16270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S28_16275	COG0857	belongs to the CobB CobQ family
M1S28_16275	COG0280	phosphate acetyltransferase
M1S28_16280	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S28_16280	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S28_16300	COG0740	serine-type endopeptidase activity
M1S28_16310	COG4774	siderophore transport
M1S28_16320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S28_16330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S28_16330	COG2813	Specifically methylates the guanine in position
M1S28_16430	COG0788	formyltetrahydrofolate deformylase activity
M1S28_16455	COG4651	solute:proton antiporter activity
M1S28_16455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S28_16475	COG0724	RNA recognition motif
M1S28_16505	COG1733	regulation of RNA biosynthetic process
M1S28_16515	COG2900	Belongs to the SlyX family
M1S28_16520	COG0488	(ABC) transporter
M1S28_16525	COG1280	lysine exporter protein (LysE YggA)
M1S28_16530	COG1560	Kdo2-lipid A biosynthetic process
M1S28_16540	COG1301	dicarboxylic acid transport
M1S28_16595	COG0473	3-isopropylmalate dehydrogenase activity
M1S28_16660	COG0583	DNA-binding transcription factor activity
M1S28_16670	COG0625	glutathione transferase activity
M1S28_16675	COG2378	regulation of single-species biofilm formation
M1S28_16680	COG0546	phosphoglycolate phosphatase activity
M1S28_16690	COG1530	ribonuclease E activity
M1S28_16695	COG0318	PFAM AMP-dependent synthetase and ligase
M1S28_16710	COG0583	DNA-binding transcription factor activity
M1S28_16715	COG4221	oxidoreductase activity
M1S28_16720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S28_16730	COG0534	Mate efflux family protein
M1S28_16745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S28_16785	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S28_16790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S28_16805	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S28_16815	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S28_16815	COG0644	oxidoreductase
M1S28_16820	COG0425	Belongs to the sulfur carrier protein TusA family
M1S28_16825	COG4535	Mg2 and Co2 transporter CorC
M1S28_16835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S28_16855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S28_16860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S28_16860	COG0475	glutathione-regulated potassium exporter activity
M1S28_16865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S28_16875	COG0484	heat shock protein binding
M1S28_16880	COG0789	Transcriptional regulator
M1S28_16885	COG0598	Magnesium transport protein CorA
M1S28_16900	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S28_16905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S28_16910	COG1074	ATP-dependent DNA helicase activity
M1S28_16915	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S28_16935	COG2226	methyltransferase
M1S28_16950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S28_16955	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S28_16970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S28_16970	COG2111	Na H antiporter
M1S28_16975	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S28_16980	COG0651	ATP synthesis coupled electron transport
M1S28_16985	COG1863	multisubunit Na H antiporter MnhE subunit
M1S28_16990	COG2212	antiporter activity
M1S28_16995	COG1320	monovalent cation:proton antiporter activity
M1S28_17010	COG0195	Participates in both transcription termination and antitermination
M1S28_17060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S28_17065	COG0237	dephospho-CoA kinase activity
M1S28_17075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S28_17090	COG0497	DNA recombination
M1S28_17100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S28_17130	COG2169	Transcriptional regulator
M1S28_17130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S28_17135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S28_17200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S28_17215	COG0326	Molecular chaperone. Has ATPase activity
M1S28_17230	COG2056	Na+-H+ antiporter family
M1S28_17235	COG0596	Alpha beta hydrolase
M1S28_17330	COG0546	phosphoglycolate phosphatase activity
M1S28_17335	COG1716	ATPase activity
M1S28_17380	COG0181	hydroxymethylbilane synthase activity
M1S28_17390	COG3275	phosphorelay sensor kinase activity
M1S28_17410	COG1538	Outer membrane efflux protein
M1S28_17415	COG0697	spore germination
M1S28_17440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S28_17445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S28_17450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S28_17455	COG0772	Belongs to the SEDS family
M1S28_17480	COG4974	Belongs to the 'phage' integrase family
M1S28_17485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S28_17495	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S28_17505	COG2197	response regulator
M1S28_17520	COG0793	Belongs to the peptidase S41A family
M1S28_17525	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S28_17530	COG0795	lipopolysaccharide-transporting ATPase activity
M1S28_17570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S28_17570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S28_17580	COG0004	ammonium transporteR
M1S28_17585	COG0347	Belongs to the P(II) protein family
M1S28_17645	COG0659	secondary active sulfate transmembrane transporter activity
M1S28_17650	COG0589	response to stress
M1S28_17685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S28_17695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S28_17715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S28_17730	COG0318	PFAM AMP-dependent synthetase and ligase
M1S28_17740	COG0477	Major facilitator Superfamily
M1S28_17745	COG2860	membrane
M1S28_17755	COG1253	flavin adenine dinucleotide binding
M1S28_17775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S28_17815	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S28_17825	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S28_17895	COG0758	DNA mediated transformation
M1S28_17905	COG0697	spore germination
M1S28_17910	COG1309	transcriptional regulator
M1S28_17925	COG0386	Belongs to the glutathione peroxidase family
M1S28_17990	COG1121	(ABC) transporter
M1S28_17995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S28_18000	COG1280	lysine exporter protein (LysE YggA)
M1S28_18005	COG2837	iron assimilation
M1S28_18015	COG0281	malic enzyme
M1S28_18060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S28_18060	COG0519	Catalyzes the synthesis of GMP from XMP
M1S28_18065	COG4399	Belongs to the UPF0754 family
M1S28_18070	COG2259	Doxx family
M1S28_18075	COG0586	Pfam SNARE associated Golgi protein
M1S28_18090	COG1192	Involved in chromosome partitioning
M1S28_18100	COG0271	Belongs to the BolA IbaG family
M1S28_18115	COG2267	carboxylic ester hydrolase activity
M1S28_18135	COG3321	synthase
M1S28_18135	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S28_18135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S28_18135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S28_18140	COG1960	acyl-CoA dehydrogenase activity
M1S28_18150	COG2197	response regulator
M1S28_18160	COG3916	Acyl-homoserine-lactone synthase
M1S28_18165	COG0477	Major facilitator Superfamily
M1S28_18170	COG1024	Enoyl-CoA hydratase
M1S28_18175	COG1024	Enoyl-CoA hydratase
M1S28_18180	COG1960	acyl-CoA dehydrogenase activity
M1S28_18185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S28_18205	COG1113	amino acid transport
M1S28_18210	COG1113	amino acid transport
M1S28_18215	COG0251	oxidation-reduction process
M1S28_18255	COG0564	pseudouridine synthase activity
M1S28_18315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S28_18330	COG1802	Transcriptional regulator
M1S28_18340	COG1448	Aminotransferase
M1S28_18345	COG0277	FAD linked oxidase domain protein
M1S28_18355	COG2186	Transcriptional regulator
M1S28_18365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S28_18370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S28_18385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S28_18390	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S28_18395	COG1216	Glycosyl transferase, family 2
M1S28_18425	COG2089	acid synthase
M1S28_18440	COG1083	cytidylyl-transferase
M1S28_18445	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S28_18450	COG1086	Polysaccharide biosynthesis protein
M1S28_18455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S28_18460	COG1596	polysaccharide export
M1S28_18485	COG0728	peptidoglycan biosynthetic process
M1S28_18490	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S28_18550	COG0546	phosphoglycolate phosphatase activity
M1S28_18555	COG1028	Short-chain dehydrogenase reductase Sdr
M1S28_18575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S28_18580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S28_18585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S28_18590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S28_18595	COG1116	anion transmembrane transporter activity
M1S28_18600	COG1309	transcriptional regulator
M1S28_18605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S28_18615	COG0196	riboflavin kinase activity
M1S28_18620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S28_18630	COG1047	Peptidyl-prolyl cis-trans
M1S28_18670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S28_18675	COG0657	acetylesterase activity
M1S28_18695	COG0583	DNA-binding transcription factor activity
M1S28_18725	COG2951	lytic endotransglycosylase activity
M1S28_18730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S28_18745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S28_18755	COG0671	phosphoesterase, PA-phosphatase related
M1S28_18760	COG0861	Integral membrane protein TerC family
M1S28_18770	COG0754	glutathionylspermidine amidase activity
M1S28_18780	COG0402	S-adenosylhomocysteine deaminase activity
M1S28_18795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S28_18800	COG1230	cation diffusion facilitator family transporter
M1S28_18815	COG0706	membrane insertase activity
M1S28_18880	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
M1S28_18900	COG1192	Involved in chromosome partitioning
M1S28_18980	COG1061	Type III restriction enzyme res subunit
M1S28_18990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S28_18995	COG1192	Involved in chromosome partitioning
M1S28_19060	COG0484	heat shock protein binding
M1S28_19190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S28_19310	COG1525	nuclease
M1S28_19395	COG0358	DNA primase activity
M1S28_19450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S28_19495	COG0587	DNA-directed DNA polymerase activity
M1S28_19510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S28_19510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S28_19560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S28_19560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S28_19565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S28_19605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S28_19650	COG1309	transcriptional regulator
M1S28_19660	COG1902	pentaerythritol trinitrate reductase activity
M1S28_19670	COG1979	alcohol dehydrogenase
M1S28_19685	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S28_19710	COG1063	alcohol dehydrogenase
M1S28_19790	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S28_19810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system