locus-tag	class	description
M1S49_00010	COG0592	DNA-directed DNA polymerase activity
M1S49_00020	COG0187	DNA topoisomerase II activity
M1S49_00030	COG0586	Pfam SNARE associated Golgi protein
M1S49_00035	COG0488	(ABC) transporter
M1S49_00060	COG0596	Alpha beta hydrolase
M1S49_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S49_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S49_00110	COG0733	neurotransmitter:sodium symporter activity
M1S49_00150	COG2233	PERMEase
M1S49_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S49_00200	COG2814	Major facilitator Superfamily
M1S49_00205	COG0656	L-ascorbic acid biosynthetic process
M1S49_00210	COG0583	DNA-binding transcription factor activity
M1S49_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S49_00230	COG1064	alcohol dehydrogenase
M1S49_00235	COG2818	Glycosylase
M1S49_00250	COG1194	a g-specific adenine glycosylase
M1S49_00270	COG2983	Belongs to the UPF0260 family
M1S49_00275	COG2133	pyrroloquinoline quinone binding
M1S49_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S49_00285	COG2116	formate transmembrane transporter activity
M1S49_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S49_00310	COG1335	isochorismatase
M1S49_00315	COG0385	Bile acid
M1S49_00320	COG0534	Mate efflux family protein
M1S49_00325	COG1683	Conserved Protein
M1S49_00345	COG0625	glutathione transferase activity
M1S49_00355	COG1113	amino acid transport
M1S49_00365	COG0523	cobalamin synthesis protein
M1S49_00375	COG2188	Transcriptional regulator
M1S49_00405	COG0010	Belongs to the arginase family
M1S49_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S49_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S49_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S49_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S49_00540	COG0534	Mate efflux family protein
M1S49_00545	COG0436	Aminotransferase
M1S49_00550	COG2733	membrane
M1S49_00565	COG2918	glutathione biosynthetic process
M1S49_00580	COG1388	LysM domain
M1S49_00580	COG0791	NLP P60 protein
M1S49_00595	COG3150	esterase
M1S49_00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S49_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S49_00630	COG2233	PERMEase
M1S49_00635	COG2351	hydroxyisourate hydrolase activity
M1S49_00670	COG3706	GGDEF domain
M1S49_00685	COG1393	Belongs to the ArsC family
M1S49_00690	COG0708	Exodeoxyribonuclease III
M1S49_00710	COG0189	ligase activity
M1S49_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S49_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S49_00755	COG4942	peptidase
M1S49_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S49_00775	COG2119	membrane
M1S49_00795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S49_00795	COG0426	domain, Protein
M1S49_00820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S49_00840	COG1902	pentaerythritol trinitrate reductase activity
M1S49_00845	COG1519	Transferase
M1S49_00850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S49_00855	COG0668	transmembrane transport
M1S49_00865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S49_00870	COG1335	isochorismatase
M1S49_00875	COG1522	sequence-specific DNA binding
M1S49_00880	COG3328	transposase activity
M1S49_00905	COG0784	Response regulator, receiver
M1S49_00905	COG2198	Histidine kinase
M1S49_00905	COG2205	protein histidine kinase activity
M1S49_00910	COG3162	membrane
M1S49_00915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S49_00925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S49_00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S49_00950	COG1309	transcriptional regulator
M1S49_00970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S49_00970	COG0352	thiamine-phosphate diphosphorylase activity
M1S49_00970	COG0351	phosphomethylpyrimidine kinase
M1S49_00980	COG2814	Major facilitator Superfamily
M1S49_00995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S49_01005	COG1113	amino acid transport
M1S49_01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S49_01020	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_01030	COG1335	isochorismatase
M1S49_01070	COG2814	Major facilitator Superfamily
M1S49_01075	COG0583	DNA-binding transcription factor activity
M1S49_01095	COG0667	Aldo Keto reductase
M1S49_01130	COG1733	regulation of RNA biosynthetic process
M1S49_01135	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S49_01200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S49_01215	COG2329	Antibiotic biosynthesis monooxygenase
M1S49_01245	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S49_01275	COG0427	acetyl-CoA hydrolase
M1S49_01300	COG0659	secondary active sulfate transmembrane transporter activity
M1S49_01305	COG4221	oxidoreductase activity
M1S49_01310	COG2873	o-acetylhomoserine
M1S49_01315	COG0488	(ABC) transporter
M1S49_01400	COG0833	amino acid
M1S49_01445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S49_01450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S49_01465	COG2226	methyltransferase
M1S49_01515	COG0067	glutamate synthase
M1S49_01515	COG0069	glutamate synthase activity
M1S49_01515	COG0070	glutamate synthase
M1S49_01520	COG0493	'glutamate synthase
M1S49_01530	COG1704	LemA family
M1S49_01535	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S49_01555	COG3307	-O-antigen
M1S49_01575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S49_01590	COG0194	GDP metabolic process
M1S49_01640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S49_01660	COG5380	lipid catabolic process
M1S49_01665	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S49_01690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S49_01695	COG0277	FAD linked oxidase domain protein
M1S49_01705	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S49_01710	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S49_01725	COG1289	transmembrane transporter activity
M1S49_01735	COG0628	permease
M1S49_01740	COG1192	Involved in chromosome partitioning
M1S49_01770	COG0833	amino acid
M1S49_01775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S49_01780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S49_01790	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_01830	COG0583	DNA-binding transcription factor activity
M1S49_01875	COG0517	IMP dehydrogenase activity
M1S49_01880	COG1983	PspC domain protein
M1S49_01890	COG1960	acyl-CoA dehydrogenase activity
M1S49_01905	COG0408	coproporphyrinogen oxidase activity
M1S49_01925	COG0513	Belongs to the DEAD box helicase family
M1S49_01935	COG1127	ABC transporter
M1S49_01940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S49_01950	COG2854	intermembrane phospholipid transfer
M1S49_01960	COG0598	Magnesium transport protein CorA
M1S49_01970	COG0494	nUDIX hydrolase
M1S49_01975	COG1040	competence protein
M1S49_01980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S49_02000	COG1946	Acyl-CoA thioesterase
M1S49_02005	COG1301	dicarboxylic acid transport
M1S49_02020	COG1959	2 iron, 2 sulfur cluster binding
M1S49_02025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S49_02025	COG1017	nitric oxide dioxygenase activity
M1S49_02030	COG0433	COG0433 Predicted ATPase
M1S49_02035	COG0626	cystathionine gamma-synthase activity
M1S49_02190	COG1960	acyl-CoA dehydrogenase activity
M1S49_02195	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S49_02225	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S49_02230	COG0339	signal peptide processing
M1S49_02235	COG0557	exoribonuclease II activity
M1S49_02280	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S49_02285	COG2169	Transcriptional regulator
M1S49_02290	COG0697	spore germination
M1S49_02295	COG1295	ribonuclease BN
M1S49_02330	COG1702	phosphate starvation-inducible protein PhoH
M1S49_02340	COG0741	lytic transglycosylase activity
M1S49_02340	COG0739	heme binding
M1S49_02340	COG1196	nuclear chromosome segregation
M1S49_02370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S49_02375	COG1183	phosphatidylcholine synthase activity
M1S49_02420	COG1960	acyl-CoA dehydrogenase activity
M1S49_02425	COG1309	transcriptional regulator
M1S49_02440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S49_02445	COG1960	acyl-CoA dehydrogenase activity
M1S49_02465	COG2969	positive regulation of protein catabolic process
M1S49_02475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S49_02490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S49_02495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S49_02515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S49_02525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S49_02530	COG1408	metallophosphoesterase
M1S49_02540	COG2199	diguanylate cyclase activity
M1S49_02600	COG1607	acyl-coa hydrolase
M1S49_02630	COG2350	Protein conserved in bacteria
M1S49_02640	COG0613	PHP domain protein
M1S49_02645	COG3781	membrane
M1S49_02655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S49_02660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S49_02670	COG1862	Preprotein translocase
M1S49_02720	COG2205	protein histidine kinase activity
M1S49_02725	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S49_02745	COG0726	polysaccharide deacetylase
M1S49_02750	COG0463	Glycosyl transferase, family 2
M1S49_02755	COG0438	transferase activity, transferring glycosyl groups
M1S49_02820	COG0625	glutathione transferase activity
M1S49_02825	COG0583	DNA-binding transcription factor activity
M1S49_02830	COG1960	acyl-CoA dehydrogenase activity
M1S49_02835	COG1960	acyl-CoA dehydrogenase activity
M1S49_02845	COG2205	protein histidine kinase activity
M1S49_02850	COG0745	RESPONSE REGULATOR receiver
M1S49_02855	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S49_02875	COG2096	Adenosyltransferase
M1S49_02925	COG0285	dihydrofolate synthase activity
M1S49_02945	COG0450	alkyl hydroperoxide reductase
M1S49_02960	COG0477	Major facilitator Superfamily
M1S49_02965	COG1272	protein, Hemolysin III
M1S49_02995	COG0183	Belongs to the thiolase family
M1S49_03000	COG2207	Transcriptional regulator
M1S49_03020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S49_03040	COG0183	Belongs to the thiolase family
M1S49_03050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S49_03050	COG2885	chlorophyll binding
M1S49_03060	COG1690	Belongs to the RtcB family
M1S49_03065	COG0833	amino acid
M1S49_03075	COG2233	PERMEase
M1S49_03080	COG1217	gtp-binding protein TYPA
M1S49_03105	COG2094	Belongs to the DNA glycosylase MPG family
M1S49_03125	COG1902	pentaerythritol trinitrate reductase activity
M1S49_03140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S49_03145	COG0354	folic acid binding
M1S49_03155	COG3189	MarR family transcriptional regulator
M1S49_03160	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S49_03165	COG3422	double-strand break repair
M1S49_03205	COG0840	transmembrane signaling receptor activity
M1S49_03225	COG5510	response to toxic substance
M1S49_03235	COG2832	Protein of unknown function (DUF454)
M1S49_03240	COG1376	ErfK ybiS ycfS ynhG family protein
M1S49_03280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S49_03290	COG1289	transmembrane transporter activity
M1S49_03295	COG2814	Major facilitator Superfamily
M1S49_03315	COG1115	amino acid carrier protein
M1S49_03320	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S49_03325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S49_03330	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S49_03360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S49_03370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S49_03375	COG1077	Cell shape determining protein MreB Mrl
M1S49_03380	COG1792	Involved in formation and maintenance of cell shape
M1S49_03385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S49_03390	COG0424	maF-like protein
M1S49_03395	COG1530	ribonuclease E activity
M1S49_03405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S49_03415	COG0560	Phosphoserine phosphatase
M1S49_03425	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S49_03450	COG2207	Transcriptional regulator
M1S49_03470	COG1113	amino acid transport
M1S49_03475	COG2828	Protein conserved in bacteria
M1S49_03480	COG0142	geranyltranstransferase activity
M1S49_03485	COG2315	Protein conserved in bacteria
M1S49_03500	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S49_03520	COG2194	sulfuric ester hydrolase activity
M1S49_03525	COG0745	RESPONSE REGULATOR receiver
M1S49_03530	COG0642	Histidine kinase
M1S49_03540	COG0004	ammonium transporteR
M1S49_03545	COG0583	DNA-binding transcription factor activity
M1S49_03565	COG0525	valine-tRNA ligase activity
M1S49_03575	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_03585	COG0393	Putative heavy-metal-binding
M1S49_03590	COG0393	Putative heavy-metal-binding
M1S49_03595	COG1538	Outer membrane efflux protein
M1S49_03605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S49_03610	COG0671	phosphoesterase, PA-phosphatase related
M1S49_03640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S49_03655	COG1648	precorrin-2 dehydrogenase activity
M1S49_03655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S49_03660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S49_03665	COG1733	regulation of RNA biosynthetic process
M1S49_03675	COG0531	amino acid
M1S49_03690	COG0321	lipoyl(octanoyl) transferase activity
M1S49_03695	COG2921	Belongs to the UPF0250 family
M1S49_03735	COG2009	succinate dehydrogenase
M1S49_03740	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S49_03745	COG1053	succinate dehydrogenase
M1S49_03750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S49_03775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S49_03795	COG2354	Protein conserved in bacteria
M1S49_03800	COG2321	neutral zinc metallopeptidase
M1S49_03820	COG2843	Capsule synthesis protein
M1S49_03835	COG0589	response to stress
M1S49_03855	COG0505	Belongs to the CarA family
M1S49_03880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S49_03885	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S49_03935	COG0477	Major facilitator Superfamily
M1S49_03940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S49_03955	COG1597	lipid kinase activity
M1S49_03960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S49_03985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S49_03990	COG0584	glycerophosphoryl diester phosphodiesterase
M1S49_04010	COG0741	lytic transglycosylase activity
M1S49_04030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S49_04045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S49_04075	COG0778	Nitroreductase
M1S49_04090	COG1929	Belongs to the glycerate kinase type-1 family
M1S49_04095	COG0243	molybdopterin cofactor binding
M1S49_04100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S49_04105	COG3339	Conserved Protein
M1S49_04115	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S49_04130	COG1113	amino acid transport
M1S49_04140	COG0019	diaminopimelate decarboxylase activity
M1S49_04150	COG1280	lysine exporter protein (LysE YggA)
M1S49_04155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S49_04185	COG0463	Glycosyl transferase, family 2
M1S49_04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S49_04240	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S49_04245	COG1136	(ABC) transporter
M1S49_04250	COG2333	competence protein COMEC
M1S49_04250	COG0658	competence protein
M1S49_04260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S49_04260	COG0616	signal peptide processing
M1S49_04265	COG0596	Alpha beta hydrolase
M1S49_04270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S49_04280	COG0628	permease
M1S49_04315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S49_04335	COG0823	Involved in the tonB-independent uptake of proteins
M1S49_04355	COG0824	Thioesterase
M1S49_04360	COG1473	amidohydrolase
M1S49_04380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S49_04380	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S49_04385	COG2814	Major facilitator Superfamily
M1S49_04395	COG1024	Enoyl-CoA hydratase
M1S49_04400	COG1056	cytidyltransferase-related domain
M1S49_04400	COG1051	belongs to the nudix hydrolase family
M1S49_04410	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S49_04425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S49_04440	COG4625	pathogenesis
M1S49_04445	COG0583	DNA-binding transcription factor activity
M1S49_04450	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S49_04455	COG4208	sulfate ABC transporter
M1S49_04460	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S49_04470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S49_04475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S49_04480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S49_04500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S49_04515	COG0681	Belongs to the peptidase S26 family
M1S49_04530	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S49_04540	COG1381	Involved in DNA repair and RecF pathway recombination
M1S49_04545	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S49_04555	COG4221	oxidoreductase activity
M1S49_04585	COG0436	Aminotransferase
M1S49_04605	COG0556	nucleotide-excision repair
M1S49_04805	COG5410	chromosome segregation
M1S49_04995	COG2070	2-Nitropropane dioxygenase
M1S49_05025	COG1215	transferase activity, transferring glycosyl groups
M1S49_05040	COG0415	Belongs to the DNA photolyase family
M1S49_05050	COG1252	NADH dehydrogenase
M1S49_05055	COG1686	Belongs to the peptidase S11 family
M1S49_05070	COG1187	pseudouridine synthase activity
M1S49_05095	COG0477	Major facilitator Superfamily
M1S49_05100	COG0583	DNA-binding transcription factor activity
M1S49_05105	COG1823	symporter activity
M1S49_05140	COG0352	thiamine-phosphate diphosphorylase activity
M1S49_05175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S49_05190	COG1309	transcriptional regulator
M1S49_05200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S49_05205	COG0076	glutamate decarboxylase activity
M1S49_05215	COG1522	sequence-specific DNA binding
M1S49_05220	COG3961	Belongs to the TPP enzyme family
M1S49_05225	COG1113	amino acid transport
M1S49_05245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S49_05250	COG0573	inorganic phosphate transmembrane transporter activity
M1S49_05260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S49_05265	COG0616	signal peptide processing
M1S49_05300	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S49_05305	COG1686	Belongs to the peptidase S11 family
M1S49_05330	COG0583	DNA-binding transcription factor activity
M1S49_05335	COG1067	ATP-dependent peptidase activity
M1S49_05380	COG1966	Carbon starvation protein
M1S49_05385	COG2879	small protein
M1S49_05420	COG2508	Transcriptional regulator
M1S49_05420	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S49_05440	COG1113	amino acid transport
M1S49_05445	COG0583	DNA-binding transcription factor activity
M1S49_05450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S49_05455	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S49_05465	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_05475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S49_05480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S49_05480	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S49_05515	COG2814	Major facilitator Superfamily
M1S49_05520	COG4948	Mandelate Racemase Muconate Lactonizing
M1S49_05530	COG1309	transcriptional regulator
M1S49_05550	COG1741	Belongs to the pirin family
M1S49_05560	COG2964	Protein conserved in bacteria
M1S49_05575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S49_05580	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S49_05585	COG4605	iron ion homeostasis
M1S49_05590	COG4604	ABC transporter, ATP-binding protein
M1S49_05595	COG4607	ABC-type enterochelin transport system periplasmic component
M1S49_05600	COG4774	siderophore transport
M1S49_05610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S49_05615	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S49_05620	COG1535	isochorismatase
M1S49_05620	COG3433	isochorismatase activity
M1S49_05635	COG1132	(ABC) transporter
M1S49_05640	COG1132	(ABC) transporter
M1S49_05645	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S49_05655	COG1169	isochorismate synthase
M1S49_05670	COG3739	integral membrane protein
M1S49_05695	COG0302	gtp cyclohydrolase
M1S49_05705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S49_05735	COG0308	aminopeptidase N
M1S49_05740	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S49_05755	COG0174	glutamine synthetase
M1S49_05765	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S49_05800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S49_05805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S49_05810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S49_05830	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S49_05835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S49_05840	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S49_05855	COG1960	acyl-CoA dehydrogenase activity
M1S49_05860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S49_05865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S49_05875	COG2223	nitrite transmembrane transporter activity
M1S49_05885	COG0024	Methionine aminopeptidase
M1S49_05890	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S49_05905	COG2207	Transcriptional regulator
M1S49_05930	COG2951	lytic endotransglycosylase activity
M1S49_05935	COG0772	Belongs to the SEDS family
M1S49_05950	COG0842	Transport permease protein
M1S49_05955	COG1131	(ABC) transporter
M1S49_06000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S49_06015	COG4215	(ABC) transporter
M1S49_06020	COG4160	amino acid transport
M1S49_06025	COG4598	ABC transporter
M1S49_06035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S49_06040	COG0826	peptidase U32
M1S49_06045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S49_06060	COG1720	tRNA m6t6A37 methyltransferase activity
M1S49_06070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S49_06085	COG0642	Histidine kinase
M1S49_06095	COG0494	nUDIX hydrolase
M1S49_06105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S49_06110	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S49_06115	COG3139	Protein of unknown function (DUF1315)
M1S49_06120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S49_06125	COG1301	dicarboxylic acid transport
M1S49_06130	COG1960	acyl-CoA dehydrogenase activity
M1S49_06135	COG2819	hydrolase of the alpha beta superfamily
M1S49_06145	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S49_06155	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S49_06160	COG1234	tRNA 3'-trailer cleavage
M1S49_06190	COG2363	Small membrane protein
M1S49_06215	COG0513	Belongs to the DEAD box helicase family
M1S49_06225	COG0778	Nitroreductase
M1S49_06255	COG1286	toxin biosynthetic process
M1S49_06280	COG4783	chaperone-mediated protein folding
M1S49_06285	COG1610	YqeY-like protein
M1S49_06385	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S49_06410	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S49_06415	COG0786	glutamate:sodium symporter activity
M1S49_06425	COG2186	Transcriptional regulator
M1S49_06475	COG0477	Major facilitator Superfamily
M1S49_06505	COG2985	domain, Protein
M1S49_06515	COG2995	paraquat-inducible protein a
M1S49_06520	COG3008	intermembrane lipid transfer
M1S49_06520	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M1S49_06530	COG1794	racemase activity, acting on amino acids and derivatives
M1S49_06625	COG0488	(ABC) transporter
M1S49_06630	COG3173	Aminoglycoside phosphotransferase
M1S49_06640	COG2433	Pfam Transposase IS66
M1S49_06670	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_06675	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S49_06680	COG0583	DNA-binding transcription factor activity
M1S49_06690	COG1414	Transcriptional regulator
M1S49_06695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S49_06705	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S49_06710	COG3842	ATPase activity
M1S49_06725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S49_06730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S49_06735	COG2814	Major facilitator Superfamily
M1S49_06740	COG1960	acyl-CoA dehydrogenase activity
M1S49_06755	COG1024	Enoyl-CoA hydratase
M1S49_06765	COG2814	Major facilitator Superfamily
M1S49_06775	COG0183	Belongs to the thiolase family
M1S49_06780	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S49_06785	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_06790	COG1024	Enoyl-CoA hydratase
M1S49_06795	COG1960	acyl-CoA dehydrogenase activity
M1S49_06800	COG2814	Major facilitator Superfamily
M1S49_06805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S49_06810	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S49_06820	COG2814	Major facilitator Superfamily
M1S49_06830	COG1960	acyl-CoA dehydrogenase activity
M1S49_06845	COG0583	DNA-binding transcription factor activity
M1S49_06855	COG4770	biotin carboxylase activity
M1S49_06860	COG1024	Enoyl-CoA hydratase
M1S49_06865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S49_06870	COG1960	acyl-CoA dehydrogenase activity
M1S49_06875	COG1309	transcriptional regulator
M1S49_06880	COG0318	PFAM AMP-dependent synthetase and ligase
M1S49_06900	COG0583	DNA-binding transcription factor activity
M1S49_06950	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_06970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S49_06990	COG0784	Response regulator, receiver
M1S49_06990	COG2205	protein histidine kinase activity
M1S49_07010	COG0765	amino acid transport
M1S49_07015	COG0765	amino acid transport
M1S49_07020	COG1126	abc transporter atp-binding protein
M1S49_07025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S49_07030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S49_07045	COG1280	lysine exporter protein (LysE YggA)
M1S49_07055	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S49_07060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S49_07065	COG1045	serine acetyltransferase
M1S49_07080	COG0583	DNA-binding transcription factor activity
M1S49_07085	COG0625	glutathione transferase activity
M1S49_07090	COG0625	glutathione transferase activity
M1S49_07095	COG0583	DNA-binding transcription factor activity
M1S49_07105	COG1346	cytolysis
M1S49_07125	COG2814	Major facilitator Superfamily
M1S49_07135	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S49_07140	COG3052	prosthetic group binding
M1S49_07160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S49_07180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S49_07190	COG1294	oxidase, subunit
M1S49_07195	COG1271	oxidase subunit
M1S49_07215	COG0477	Major facilitator Superfamily
M1S49_07225	COG4521	taurine ABC transporter
M1S49_07230	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S49_07235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S49_07240	COG2175	clavaminate synthase activity
M1S49_07250	COG1953	Uracil, thiamine, allantoin
M1S49_07260	COG0583	DNA-binding transcription factor activity
M1S49_07270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S49_07285	COG0640	Transcriptional regulator
M1S49_07290	COG0798	PFAM Bile acid sodium symporter
M1S49_07295	COG0583	DNA-binding transcription factor activity
M1S49_07310	COG3634	alkyl hydroperoxide reductase activity
M1S49_07350	COG0436	Aminotransferase
M1S49_07360	COG0386	Belongs to the glutathione peroxidase family
M1S49_07400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S49_07425	COG0012	GTP binding
M1S49_07430	COG2011	ABC-type metal ion transport system permease component
M1S49_07435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S49_07445	COG1464	Belongs to the NlpA lipoprotein family
M1S49_07475	COG0765	amino acid transport
M1S49_07480	COG0765	amino acid transport
M1S49_07485	COG1126	abc transporter atp-binding protein
M1S49_07495	COG1522	sequence-specific DNA binding
M1S49_07510	COG1309	transcriptional regulator
M1S49_07530	COG0583	DNA-binding transcription factor activity
M1S49_07540	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S49_07550	COG0697	spore germination
M1S49_07575	COG3121	Chaperone
M1S49_07580	COG3539	Fimbrial protein
M1S49_07605	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S49_07605	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S49_07650	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S49_07660	COG2353	YceI-like domain
M1S49_07670	COG3698	Phosphodiester glycosidase
M1S49_07685	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S49_07690	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S49_07690	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S49_07690	COG0506	proline dehydrogenase activity
M1S49_07700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S49_07705	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S49_07725	COG1132	(ABC) transporter
M1S49_07730	COG3122	Protein conserved in bacteria
M1S49_07735	COG3619	membrane
M1S49_07745	COG0640	Transcriptional regulator
M1S49_07755	COG2850	peptidyl-arginine hydroxylation
M1S49_07760	COG0424	maF-like protein
M1S49_07780	COG0191	fructose-bisphosphate aldolase activity
M1S49_07785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S49_07800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S49_07810	COG1192	Involved in chromosome partitioning
M1S49_07815	COG1475	DNA binding
M1S49_07820	COG0811	peptide transport
M1S49_07830	COG1132	(ABC) transporter
M1S49_07835	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S49_07855	COG0084	hydrolase, TatD family'
M1S49_07920	COG0776	regulation of translation
M1S49_07950	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S49_07955	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S49_08005	COG0339	signal peptide processing
M1S49_08015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S49_08050	COG0702	epimerase
M1S49_08055	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S49_08075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S49_08105	COG0316	Belongs to the HesB IscA family
M1S49_08110	COG0822	iron-sulfur transferase activity
M1S49_08135	COG0776	regulation of translation
M1S49_08140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S49_08145	COG2207	Transcriptional regulator
M1S49_08150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S49_08155	COG1960	acyl-CoA dehydrogenase activity
M1S49_08160	COG1960	acyl-CoA dehydrogenase activity
M1S49_08175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S49_08195	COG4264	IucA IucC family
M1S49_08200	COG4264	IucA IucC family
M1S49_08240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S49_08255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S49_08275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S49_08280	COG0730	response to heat
M1S49_08300	COG4773	Receptor
M1S49_08305	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S49_08320	COG1131	(ABC) transporter
M1S49_08325	COG0842	Transport permease protein
M1S49_08330	COG0842	Transport permease protein
M1S49_08385	COG2226	methyltransferase
M1S49_08410	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S49_08450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S49_08460	COG0133	tryptophan synthase activity
M1S49_08475	COG3706	GGDEF domain
M1S49_08490	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S49_08495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S49_08500	COG0022	dehydrogenase e1 component
M1S49_08505	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S49_08510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S49_08520	COG1063	alcohol dehydrogenase
M1S49_08525	COG3781	membrane
M1S49_08535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S49_08535	COG3453	Protein conserved in bacteria
M1S49_08550	COG0730	response to heat
M1S49_08565	COG2207	Transcriptional regulator
M1S49_08565	COG3708	Transcriptional regulator
M1S49_08570	COG1733	regulation of RNA biosynthetic process
M1S49_08575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S49_08585	COG2188	Transcriptional regulator
M1S49_08600	COG4521	taurine ABC transporter
M1S49_08605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S49_08625	COG0477	Major facilitator Superfamily
M1S49_08650	COG0583	DNA-binding transcription factor activity
M1S49_08655	COG0583	DNA-binding transcription factor activity
M1S49_08660	COG0183	Belongs to the thiolase family
M1S49_08665	COG2031	fatty acid transporter
M1S49_08670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S49_08680	COG0583	DNA-binding transcription factor activity
M1S49_08690	COG2610	gluconate transmembrane transporter activity
M1S49_08695	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_08705	COG2207	Transcriptional regulator
M1S49_08720	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_08745	COG0543	2 iron, 2 sulfur cluster binding
M1S49_08745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S49_08750	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S49_08755	COG4638	Rieske (2fe-2S)
M1S49_08765	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S49_08770	COG4149	molybdate abc transporter
M1S49_08775	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S49_08780	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_08785	COG3433	isochorismatase activity
M1S49_08785	COG1535	isochorismatase
M1S49_08850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S49_08865	COG0753	catalase activity
M1S49_08875	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S49_08905	COG3539	Fimbrial protein
M1S49_08925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S49_08945	COG2072	flavoprotein involved in K transport
M1S49_08955	COG1538	Outer membrane efflux protein
M1S49_08960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S49_08965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S49_08970	COG0745	RESPONSE REGULATOR receiver
M1S49_08975	COG2205	protein histidine kinase activity
M1S49_08985	COG2207	Transcriptional regulator
M1S49_09000	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_09050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S49_09170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S49_09190	COG1120	ATPase activity
M1S49_09195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S49_09205	COG1064	alcohol dehydrogenase
M1S49_09220	COG2207	Transcriptional regulator
M1S49_09225	COG2084	Dehydrogenase
M1S49_09235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S49_09240	COG0583	DNA-binding transcription factor activity
M1S49_09250	COG0129	dihydroxy-acid dehydratase activity
M1S49_09255	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_09270	COG1566	PFAM secretion protein HlyD family protein
M1S49_09310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S49_09340	COG0583	DNA-binding transcription factor activity
M1S49_09355	COG2188	Transcriptional regulator
M1S49_09385	COG3210	domain, Protein
M1S49_09390	COG2831	hemolysin activation secretion protein
M1S49_09400	COG1473	amidohydrolase
M1S49_09410	COG0475	glutathione-regulated potassium exporter activity
M1S49_09410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S49_09420	COG0583	DNA-binding transcription factor activity
M1S49_09425	COG1335	isochorismatase
M1S49_09435	COG1309	transcriptional regulator
M1S49_09465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S49_09475	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S49_09475	COG1902	pentaerythritol trinitrate reductase activity
M1S49_09480	COG1846	Transcriptional regulator
M1S49_09500	COG0753	catalase activity
M1S49_09515	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_09530	COG3162	membrane
M1S49_09540	COG3829	transcription factor binding
M1S49_09545	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_09570	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_09590	COG2186	Transcriptional regulator
M1S49_09600	COG0583	DNA-binding transcription factor activity
M1S49_09605	COG4948	Mandelate Racemase Muconate Lactonizing
M1S49_09610	COG4829	muconolactone delta-isomerase
M1S49_09620	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S49_09625	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S49_09630	COG0183	Belongs to the thiolase family
M1S49_09635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S49_09645	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_09655	COG3733	amine oxidase
M1S49_09665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S49_09675	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_09685	COG4638	Rieske (2fe-2S)
M1S49_09705	COG0154	amidase activity
M1S49_09715	COG2814	Major facilitator Superfamily
M1S49_09740	COG1960	acyl-CoA dehydrogenase activity
M1S49_09745	COG0583	DNA-binding transcription factor activity
M1S49_09750	COG1414	Transcriptional regulator
M1S49_09765	COG2391	methyltransferase activity
M1S49_09775	COG4993	Dehydrogenase
M1S49_09780	COG3659	wide pore channel activity
M1S49_09785	COG3420	alginic acid biosynthetic process
M1S49_09790	COG0710	3-dehydroquinate dehydratase activity
M1S49_09795	COG3485	protocatechuate 3,4-dioxygenase
M1S49_09800	COG3485	protocatechuate 3,4-dioxygenase
M1S49_09805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S49_09810	COG2271	Major facilitator Superfamily
M1S49_09815	COG0596	Alpha beta hydrolase
M1S49_09820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S49_09825	COG0183	Belongs to the thiolase family
M1S49_09830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S49_09835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S49_09845	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S49_09850	COG2323	membrane
M1S49_09895	COG1902	pentaerythritol trinitrate reductase activity
M1S49_09895	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S49_09920	COG0542	response to heat
M1S49_09925	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S49_09955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S49_09960	COG0569	domain protein
M1S49_09965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S49_09980	COG4774	siderophore transport
M1S49_09985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S49_09995	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S49_10015	COG1294	oxidase, subunit
M1S49_10020	COG4890	Cyd operon protein YbgT
M1S49_10035	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S49_10045	COG0552	protein localization to endoplasmic reticulum
M1S49_10070	COG0517	IMP dehydrogenase activity
M1S49_10070	COG0516	GMP reductase activity
M1S49_10075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S49_10080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S49_10090	COG0583	DNA-binding transcription factor activity
M1S49_10095	COG0024	Methionine aminopeptidase
M1S49_10125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S49_10125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S49_10130	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S49_10135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S49_10135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S49_10135	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S49_10155	COG3300	MHYT domain
M1S49_10155	COG5001	Diguanylate cyclase
M1S49_10170	COG2135	peptidase activity
M1S49_10175	COG0659	secondary active sulfate transmembrane transporter activity
M1S49_10195	COG1113	amino acid transport
M1S49_10205	COG1522	sequence-specific DNA binding
M1S49_10230	COG1011	Hydrolase
M1S49_10235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S49_10245	COG2137	regulation of response to DNA damage stimulus
M1S49_10260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S49_10295	COG0575	Belongs to the CDS family
M1S49_10300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S49_10320	COG3852	Histidine kinase
M1S49_10325	COG2204	response regulator
M1S49_10380	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S49_10385	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S49_10405	COG0697	spore germination
M1S49_10410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S49_10420	COG0303	'Molybdopterin
M1S49_10425	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S49_10425	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S49_10440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S49_10445	COG0243	molybdopterin cofactor binding
M1S49_10455	COG0243	molybdopterin cofactor binding
M1S49_10460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S49_10465	COG2146	nitrite reductase [NAD(P)H] activity
M1S49_10465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S49_10475	COG0745	RESPONSE REGULATOR receiver
M1S49_10480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S49_10480	COG1116	anion transmembrane transporter activity
M1S49_10500	COG0511	ligase activity, forming carbon-carbon bonds
M1S49_10515	COG2814	Major facilitator Superfamily
M1S49_10570	COG0739	heme binding
M1S49_10605	COG1598	PFAM Uncharacterised protein family UPF0150
M1S49_10705	COG5410	chromosome segregation
M1S49_10875	COG0069	glutamate synthase activity
M1S49_10895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S49_10905	COG1454	alcohol dehydrogenase
M1S49_10910	COG0824	Thioesterase
M1S49_10920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S49_10935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S49_10940	COG2030	dehydratase
M1S49_10950	COG0183	Belongs to the thiolase family
M1S49_10960	COG0583	DNA-binding transcription factor activity
M1S49_10965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S49_10975	COG1522	sequence-specific DNA binding
M1S49_10980	COG3135	benzoate transporter
M1S49_10990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S49_11015	COG0589	response to stress
M1S49_11020	COG0488	(ABC) transporter
M1S49_11040	COG4773	Receptor
M1S49_11075	COG0668	transmembrane transport
M1S49_11085	COG1309	transcriptional regulator
M1S49_11105	COG1605	Chorismate mutase
M1S49_11115	COG4221	oxidoreductase activity
M1S49_11125	COG0308	aminopeptidase N
M1S49_11145	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S49_11155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S49_11160	COG1454	alcohol dehydrogenase
M1S49_11180	COG0531	amino acid
M1S49_11185	COG4303	Ethanolamine ammonia lyase large subunit
M1S49_11190	COG4302	ethanolamine ammonia-lyase activity
M1S49_11195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S49_11195	COG0519	Catalyzes the synthesis of GMP from XMP
M1S49_11200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S49_11210	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S49_11225	COG0697	spore germination
M1S49_11230	COG1923	regulation of RNA biosynthetic process
M1S49_11240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S49_11245	COG0802	atpase or kinase
M1S49_11265	COG1187	pseudouridine synthase activity
M1S49_11280	COG0583	DNA-binding transcription factor activity
M1S49_11295	COG2814	Major facilitator Superfamily
M1S49_11300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S49_11325	COG0729	surface antigen
M1S49_11345	COG0174	glutamine synthetase
M1S49_11350	COG0745	RESPONSE REGULATOR receiver
M1S49_11355	COG2205	protein histidine kinase activity
M1S49_11365	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S49_11370	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S49_11395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S49_11400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S49_11405	COG1960	acyl-CoA dehydrogenase activity
M1S49_11420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S49_11425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S49_11445	COG0583	DNA-binding transcription factor activity
M1S49_11460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S49_11470	COG3658	cytochrome
M1S49_11475	COG1215	transferase activity, transferring glycosyl groups
M1S49_11480	COG0726	polysaccharide deacetylase
M1S49_11480	COG1649	PFAM Uncharacterised BCR, COG1649
M1S49_11505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S49_11510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S49_11520	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S49_11545	COG0305	Participates in initiation and elongation during chromosome replication
M1S49_11550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S49_11560	COG1305	Transglutaminase-like
M1S49_11570	COG2308	Evidence 4 Homologs of previously reported genes of
M1S49_11600	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S49_11605	COG0138	bifunctional purine biosynthesis protein purh
M1S49_11610	COG0151	Belongs to the GarS family
M1S49_11615	COG1464	Belongs to the NlpA lipoprotein family
M1S49_11620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S49_11625	COG2011	ABC-type metal ion transport system permease component
M1S49_11630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S49_11640	COG1301	dicarboxylic acid transport
M1S49_11665	COG0753	catalase activity
M1S49_11700	COG2050	protein possibly involved in aromatic compounds catabolism
M1S49_11710	COG3327	negative regulation of DNA-templated transcription, initiation
M1S49_11715	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S49_11720	COG0183	Belongs to the thiolase family
M1S49_11725	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S49_11730	COG1024	Enoyl-CoA hydratase
M1S49_11735	COG1024	Enoyl-CoA hydratase
M1S49_11740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S49_11745	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S49_11750	COG3396	Phenylacetate-CoA oxygenase
M1S49_11755	COG3460	Phenylacetate-CoA oxygenase
M1S49_11760	COG3396	Phenylacetate-CoA oxygenase
M1S49_11765	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_11765	COG2030	dehydratase
M1S49_11770	COG1760	l-serine dehydratase
M1S49_11775	COG0531	amino acid
M1S49_11780	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_11795	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S49_11805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S49_11825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S49_11835	COG0789	Transcriptional regulator
M1S49_11850	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S49_11865	COG2807	transmembrane transport
M1S49_11870	COG0590	tRNA wobble adenosine to inosine editing
M1S49_11990	COG1116	anion transmembrane transporter activity
M1S49_11995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S49_12005	COG0864	Transcriptional regulator
M1S49_12025	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S49_12030	COG0439	Biotin carboxylase
M1S49_12045	COG1063	alcohol dehydrogenase
M1S49_12055	COG1309	transcriptional regulator
M1S49_12075	COG0038	chloride channel
M1S49_12080	COG4770	biotin carboxylase activity
M1S49_12100	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S49_12105	COG0583	DNA-binding transcription factor activity
M1S49_12155	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S49_12190	COG1560	Kdo2-lipid A biosynthetic process
M1S49_12200	COG5006	permease, DMT superfamily
M1S49_12205	COG1522	sequence-specific DNA binding
M1S49_12220	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S49_12230	COG4122	O-methyltransferase activity
M1S49_12260	COG1538	Outer membrane efflux protein
M1S49_12265	COG1137	ATPase activity
M1S49_12270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S49_12280	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S49_12285	COG0517	IMP dehydrogenase activity
M1S49_12285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S49_12320	COG2814	Major facilitator Superfamily
M1S49_12355	COG1278	Cold shock
M1S49_12360	COG1280	lysine exporter protein (LysE YggA)
M1S49_12395	COG1570	exodeoxyribonuclease VII activity
M1S49_12445	COG0583	DNA-binding transcription factor activity
M1S49_12455	COG4638	Rieske (2fe-2S)
M1S49_12460	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S49_12465	COG0633	Ferredoxin
M1S49_12465	COG0543	2 iron, 2 sulfur cluster binding
M1S49_12470	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_12475	COG3135	benzoate transporter
M1S49_12480	COG2814	Major facilitator Superfamily
M1S49_12495	COG1643	Atp-dependent helicase
M1S49_12500	COG0450	alkyl hydroperoxide reductase
M1S49_12510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S49_12520	COG3634	alkyl hydroperoxide reductase activity
M1S49_12540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S49_12545	COG0625	glutathione transferase activity
M1S49_12555	COG2885	chlorophyll binding
M1S49_12595	COG0542	response to heat
M1S49_12610	COG1765	OsmC-like protein
M1S49_12630	COG0667	Aldo Keto reductase
M1S49_12645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S49_12655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S49_12665	COG0527	aspartate kinase activity
M1S49_12675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S49_12685	COG3038	cytochrome b561
M1S49_12690	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S49_12695	COG2252	PERMEase
M1S49_12750	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_12770	COG0531	amino acid
M1S49_12780	COG1113	amino acid transport
M1S49_12820	COG3209	COG3209 Rhs family protein
M1S49_12850	COG4269	membrane
M1S49_12865	COG1902	pentaerythritol trinitrate reductase activity
M1S49_12865	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S49_12875	COG2203	Gaf domain
M1S49_12875	COG4251	negative regulation of phosphorylation
M1S49_12875	COG5001	Diguanylate cyclase
M1S49_12875	COG3706	GGDEF domain
M1S49_12885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S49_12905	COG4172	Belongs to the ABC transporter superfamily
M1S49_12910	COG4239	(ABC) transporter, permease
M1S49_12915	COG4174	ABC transporter (Permease)
M1S49_12925	COG1388	LysM domain
M1S49_12925	COG0741	lytic transglycosylase activity
M1S49_12925	COG0741	lytic transglycosylase activity
M1S49_12925	COG1388	LysM domain
M1S49_12930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S49_12970	COG0583	DNA-binding transcription factor activity
M1S49_12975	COG1279	arginine transmembrane transporter activity
M1S49_12995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S49_13000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S49_13005	COG0006	proline dipeptidase activity
M1S49_13045	COG2194	sulfuric ester hydrolase activity
M1S49_13100	COG0739	heme binding
M1S49_13425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S49_13450	COG3384	dioxygenase
M1S49_13460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S49_13465	COG2878	Part of a membrane complex involved in electron transport
M1S49_13470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S49_13495	COG0768	penicillin binding
M1S49_13500	COG0742	ribosomal rna small subunit methyltransferase
M1S49_13515	COG0830	nickel cation binding
M1S49_13525	COG0804	urea catabolic process
M1S49_13565	COG1253	flavin adenine dinucleotide binding
M1S49_13570	COG2851	Citrate transporter
M1S49_13620	COG1773	rubredoxin
M1S49_13625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S49_13635	COG0583	DNA-binding transcription factor activity
M1S49_13660	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S49_13665	COG4181	ATPase activity
M1S49_13710	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S49_13730	COG0306	phosphate transporter
M1S49_13740	COG3958	Transketolase
M1S49_13745	COG3959	Transketolase, thiamine diphosphate binding domain
M1S49_13750	COG2271	Major facilitator Superfamily
M1S49_13755	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_13760	COG0583	DNA-binding transcription factor activity
M1S49_13775	COG2223	nitrite transmembrane transporter activity
M1S49_13780	COG2207	Transcriptional regulator
M1S49_13785	COG2066	Belongs to the glutaminase family
M1S49_13790	COG0242	peptide deformylase activity
M1S49_13795	COG0477	Major facilitator Superfamily
M1S49_13805	COG0028	Belongs to the TPP enzyme family
M1S49_13820	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_13825	COG2267	carboxylic ester hydrolase activity
M1S49_13835	COG2271	Major facilitator Superfamily
M1S49_13840	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S49_13850	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_13870	COG1414	Transcriptional regulator
M1S49_13885	COG1024	Enoyl-CoA hydratase
M1S49_13895	COG1215	transferase activity, transferring glycosyl groups
M1S49_13900	COG1649	PFAM Uncharacterised BCR, COG1649
M1S49_13900	COG0726	polysaccharide deacetylase
M1S49_13910	COG4681	YaeQ
M1S49_13920	COG0523	cobalamin synthesis protein
M1S49_13930	COG1607	acyl-coa hydrolase
M1S49_13940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S49_13945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S49_13950	COG1309	transcriptional regulator
M1S49_13975	COG2040	homocysteine
M1S49_13980	COG0531	amino acid
M1S49_14035	COG1595	DNA-templated transcription, initiation
M1S49_14045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S49_14050	COG0477	Major facilitator Superfamily
M1S49_14070	COG0084	hydrolase, TatD family'
M1S49_14110	COG0629	single-stranded DNA binding
M1S49_14155	COG0582	viral genome integration into host DNA
M1S49_14165	COG0405	Gamma-glutamyltransferase
M1S49_14170	COG2814	Major facilitator Superfamily
M1S49_14180	COG2050	protein possibly involved in aromatic compounds catabolism
M1S49_14195	COG1090	epimerase
M1S49_14215	COG0420	3'-5' exonuclease activity
M1S49_14240	COG0735	belongs to the Fur family
M1S49_14245	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S49_14265	COG0121	glutamine amidotransferase
M1S49_14280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S49_14290	COG0210	DNA helicase
M1S49_14295	COG2885	chlorophyll binding
M1S49_14300	COG0204	Acyl-transferase
M1S49_14315	COG2894	cell division
M1S49_14335	COG1280	lysine exporter protein (LysE YggA)
M1S49_14340	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S49_14340	COG1674	ftsk spoiiie
M1S49_14345	COG0492	ferredoxin-NADP+ reductase activity
M1S49_14350	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S49_14360	COG0456	acetyltransferase
M1S49_14405	COG1981	membrane
M1S49_14420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S49_14420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S49_14440	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_14450	COG0657	acetylesterase activity
M1S49_14460	COG0473	3-isopropylmalate dehydrogenase activity
M1S49_14465	COG0583	DNA-binding transcription factor activity
M1S49_14485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S49_14510	COG0564	pseudouridine synthase activity
M1S49_14520	COG0358	DNA primase activity
M1S49_14535	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S49_14565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S49_14595	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S49_14605	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S49_14605	COG0351	phosphomethylpyrimidine kinase
M1S49_14605	COG0352	thiamine-phosphate diphosphorylase activity
M1S49_14610	COG1652	LysM domain
M1S49_14635	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S49_14640	COG3101	peptidyl-lysine hydroxylation
M1S49_14645	COG0009	L-threonylcarbamoyladenylate synthase
M1S49_14650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S49_14655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S49_14670	COG4106	trans-aconitate 2-methyltransferase activity
M1S49_14685	COG0596	Alpha beta hydrolase
M1S49_14685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S49_14685	COG2226	methyltransferase
M1S49_14690	COG1877	trehalose-phosphatase activity
M1S49_14695	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S49_14700	COG2223	nitrite transmembrane transporter activity
M1S49_14720	COG1196	nuclear chromosome segregation
M1S49_14730	COG0730	response to heat
M1S49_14745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S49_14755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S49_14805	COG0489	protein tyrosine kinase activity
M1S49_14815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S49_14815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S49_14845	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S49_14850	COG2081	HI0933 family
M1S49_14860	COG0668	transmembrane transport
M1S49_14880	COG0583	DNA-binding transcription factor activity
M1S49_14900	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S49_14905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S49_14935	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S49_14975	COG0745	RESPONSE REGULATOR receiver
M1S49_14995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S49_15005	COG2205	protein histidine kinase activity
M1S49_15075	COG4993	Dehydrogenase
M1S49_15100	COG0384	phenazine biosynthesis protein PhzF
M1S49_15125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S49_15140	COG0583	DNA-binding transcription factor activity
M1S49_15170	COG0583	DNA-binding transcription factor activity
M1S49_15185	COG0583	DNA-binding transcription factor activity
M1S49_15190	COG1053	succinate dehydrogenase
M1S49_15200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S49_15205	COG2814	Major facilitator Superfamily
M1S49_15210	COG1960	acyl-CoA dehydrogenase activity
M1S49_15215	COG0583	DNA-binding transcription factor activity
M1S49_15220	COG1063	alcohol dehydrogenase
M1S49_15250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S49_15255	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S49_15260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S49_15275	COG3667	copper resistance
M1S49_15280	COG2132	Multicopper oxidase
M1S49_15290	COG0561	phosphatase activity
M1S49_15295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S49_15320	COG1214	PFAM Peptidase M22, glycoprotease
M1S49_15370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S49_15380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S49_15385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S49_15390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S49_15450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S49_15460	COG1846	Transcriptional regulator
M1S49_15465	COG1764	response to oxidative stress
M1S49_15505	COG0037	tRNA processing
M1S49_15515	COG0248	Ppx GppA phosphatase
M1S49_15545	COG0072	phenylalanine-tRNA ligase activity
M1S49_15590	COG1238	metal cluster binding
M1S49_15595	COG0625	glutathione transferase activity
M1S49_15610	COG0318	PFAM AMP-dependent synthetase and ligase
M1S49_15615	COG3028	Belongs to the UPF0307 family
M1S49_15620	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S49_15640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S49_15645	COG0617	tRNA 3'-terminal CCA addition
M1S49_15650	COG1555	photosystem II stabilization
M1S49_15655	COG3956	TIGRFAM MazG family protein
M1S49_15665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S49_15685	COG0784	Response regulator, receiver
M1S49_15685	COG2205	protein histidine kinase activity
M1S49_15685	COG5002	protein histidine kinase activity
M1S49_15690	COG1024	Enoyl-CoA hydratase
M1S49_15695	COG2084	Dehydrogenase
M1S49_15700	COG3622	Belongs to the hyi family
M1S49_15730	COG0697	spore germination
M1S49_15740	COG2814	Major facilitator Superfamily
M1S49_15745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S49_15755	COG0583	DNA-binding transcription factor activity
M1S49_15765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S49_15780	COG0084	hydrolase, TatD family'
M1S49_15795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S49_15825	COG0440	acetolactate synthase activity
M1S49_15830	COG0028	Belongs to the TPP enzyme family
M1S49_15855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S49_15860	COG1136	(ABC) transporter
M1S49_15860	COG0577	efflux transmembrane transporter activity
M1S49_15865	COG1538	Outer membrane efflux protein
M1S49_15880	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S49_15885	COG1162	GTPase activity
M1S49_15895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S49_15915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S49_15920	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_15960	COG2986	histidine ammonia-lyase
M1S49_15975	COG0318	PFAM AMP-dependent synthetase and ligase
M1S49_15985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S49_16030	COG1426	Protein conserved in bacteria
M1S49_16065	COG0793	Belongs to the peptidase S41A family
M1S49_16080	COG2267	carboxylic ester hydrolase activity
M1S49_16090	COG1012	belongs to the aldehyde dehydrogenase family
M1S49_16095	COG3265	gluconokinase activity
M1S49_16105	COG0800	Aldolase
M1S49_16115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S49_16120	COG0280	phosphate acetyltransferase
M1S49_16120	COG0857	belongs to the CobB CobQ family
M1S49_16125	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S49_16125	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S49_16145	COG0740	serine-type endopeptidase activity
M1S49_16155	COG4774	siderophore transport
M1S49_16165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S49_16175	COG2813	Specifically methylates the guanine in position
M1S49_16175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S49_16275	COG0788	formyltetrahydrofolate deformylase activity
M1S49_16300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S49_16300	COG4651	solute:proton antiporter activity
M1S49_16320	COG0724	RNA recognition motif
M1S49_16325	COG0210	DNA helicase
M1S49_16350	COG1733	regulation of RNA biosynthetic process
M1S49_16360	COG2900	Belongs to the SlyX family
M1S49_16365	COG0488	(ABC) transporter
M1S49_16370	COG1280	lysine exporter protein (LysE YggA)
M1S49_16375	COG1560	Kdo2-lipid A biosynthetic process
M1S49_16385	COG1301	dicarboxylic acid transport
M1S49_16440	COG0473	3-isopropylmalate dehydrogenase activity
M1S49_16505	COG0583	DNA-binding transcription factor activity
M1S49_16515	COG0625	glutathione transferase activity
M1S49_16520	COG2378	regulation of single-species biofilm formation
M1S49_16525	COG0546	phosphoglycolate phosphatase activity
M1S49_16535	COG1530	ribonuclease E activity
M1S49_16540	COG0318	PFAM AMP-dependent synthetase and ligase
M1S49_16555	COG0583	DNA-binding transcription factor activity
M1S49_16560	COG4221	oxidoreductase activity
M1S49_16565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S49_16575	COG0534	Mate efflux family protein
M1S49_16590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S49_16630	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S49_16635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S49_16650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S49_16660	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S49_16660	COG0644	oxidoreductase
M1S49_16665	COG0425	Belongs to the sulfur carrier protein TusA family
M1S49_16670	COG4535	Mg2 and Co2 transporter CorC
M1S49_16680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S49_16700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S49_16705	COG0475	glutathione-regulated potassium exporter activity
M1S49_16705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S49_16710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S49_16720	COG0484	heat shock protein binding
M1S49_16725	COG0789	Transcriptional regulator
M1S49_16730	COG0598	Magnesium transport protein CorA
M1S49_16745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S49_16750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S49_16755	COG1074	ATP-dependent DNA helicase activity
M1S49_16760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S49_16780	COG2226	methyltransferase
M1S49_16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S49_16800	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S49_16815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S49_16815	COG2111	Na H antiporter
M1S49_16820	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S49_16825	COG0651	ATP synthesis coupled electron transport
M1S49_16830	COG1863	multisubunit Na H antiporter MnhE subunit
M1S49_16835	COG2212	antiporter activity
M1S49_16840	COG1320	monovalent cation:proton antiporter activity
M1S49_16855	COG0195	Participates in both transcription termination and antitermination
M1S49_16905	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S49_16910	COG0237	dephospho-CoA kinase activity
M1S49_16920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S49_16935	COG0497	DNA recombination
M1S49_16945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S49_16975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S49_16975	COG2169	Transcriptional regulator
M1S49_16980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S49_17045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S49_17060	COG0326	Molecular chaperone. Has ATPase activity
M1S49_17075	COG2056	Na+-H+ antiporter family
M1S49_17080	COG0596	Alpha beta hydrolase
M1S49_17175	COG0546	phosphoglycolate phosphatase activity
M1S49_17180	COG1716	ATPase activity
M1S49_17225	COG0181	hydroxymethylbilane synthase activity
M1S49_17235	COG3275	phosphorelay sensor kinase activity
M1S49_17255	COG1538	Outer membrane efflux protein
M1S49_17260	COG0697	spore germination
M1S49_17285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S49_17290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S49_17295	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S49_17300	COG0772	Belongs to the SEDS family
M1S49_17325	COG4974	Belongs to the 'phage' integrase family
M1S49_17330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S49_17340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S49_17350	COG2197	response regulator
M1S49_17365	COG0793	Belongs to the peptidase S41A family
M1S49_17370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S49_17375	COG0795	lipopolysaccharide-transporting ATPase activity
M1S49_17415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S49_17415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S49_17425	COG0004	ammonium transporteR
M1S49_17430	COG0347	Belongs to the P(II) protein family
M1S49_17490	COG0659	secondary active sulfate transmembrane transporter activity
M1S49_17495	COG0589	response to stress
M1S49_17535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S49_17580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S49_17655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S49_17700	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S49_17730	COG0659	secondary active sulfate transmembrane transporter activity
M1S49_17735	COG0589	response to stress
M1S49_17770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S49_17780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S49_17800	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S49_17815	COG0318	PFAM AMP-dependent synthetase and ligase
M1S49_17825	COG0477	Major facilitator Superfamily
M1S49_17830	COG2860	membrane
M1S49_17840	COG1253	flavin adenine dinucleotide binding
M1S49_17860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S49_17905	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S49_17915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S49_17985	COG0758	DNA mediated transformation
M1S49_17995	COG0697	spore germination
M1S49_18000	COG1309	transcriptional regulator
M1S49_18015	COG0386	Belongs to the glutathione peroxidase family
M1S49_18080	COG1121	(ABC) transporter
M1S49_18085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S49_18090	COG1280	lysine exporter protein (LysE YggA)
M1S49_18095	COG2837	iron assimilation
M1S49_18105	COG0281	malic enzyme
M1S49_18150	COG0519	Catalyzes the synthesis of GMP from XMP
M1S49_18150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S49_18155	COG4399	Belongs to the UPF0754 family
M1S49_18160	COG2259	Doxx family
M1S49_18165	COG0586	Pfam SNARE associated Golgi protein
M1S49_18180	COG1192	Involved in chromosome partitioning
M1S49_18190	COG0271	Belongs to the BolA IbaG family
M1S49_18210	COG2267	carboxylic ester hydrolase activity
M1S49_18230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S49_18230	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S49_18230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S49_18230	COG3321	synthase
M1S49_18235	COG1960	acyl-CoA dehydrogenase activity
M1S49_18245	COG2197	response regulator
M1S49_18255	COG3916	Acyl-homoserine-lactone synthase
M1S49_18260	COG0477	Major facilitator Superfamily
M1S49_18265	COG1024	Enoyl-CoA hydratase
M1S49_18270	COG1024	Enoyl-CoA hydratase
M1S49_18275	COG1960	acyl-CoA dehydrogenase activity
M1S49_18280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S49_18300	COG1113	amino acid transport
M1S49_18305	COG1113	amino acid transport
M1S49_18310	COG0251	oxidation-reduction process
M1S49_18350	COG0564	pseudouridine synthase activity
M1S49_18420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S49_18435	COG1802	Transcriptional regulator
M1S49_18450	COG0277	FAD linked oxidase domain protein
M1S49_18460	COG2186	Transcriptional regulator
M1S49_18470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S49_18475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S49_18490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S49_18495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S49_18520	COG2244	polysaccharide biosynthetic process
M1S49_18525	COG2089	acid synthase
M1S49_18540	COG1083	cytidylyl-transferase
M1S49_18545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S49_18550	COG1086	Polysaccharide biosynthesis protein
M1S49_18555	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S49_18560	COG1596	polysaccharide export
M1S49_18585	COG0728	peptidoglycan biosynthetic process
M1S49_18590	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S49_18650	COG0546	phosphoglycolate phosphatase activity
M1S49_18655	COG1028	Short-chain dehydrogenase reductase Sdr
M1S49_18675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S49_18680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S49_18685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S49_18690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S49_18695	COG1116	anion transmembrane transporter activity
M1S49_18700	COG1309	transcriptional regulator
M1S49_18705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S49_18715	COG0196	riboflavin kinase activity
M1S49_18720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S49_18730	COG1047	Peptidyl-prolyl cis-trans
M1S49_18770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S49_18775	COG0657	acetylesterase activity
M1S49_18795	COG0583	DNA-binding transcription factor activity
M1S49_18825	COG2951	lytic endotransglycosylase activity
M1S49_18830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S49_18845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S49_18855	COG0671	phosphoesterase, PA-phosphatase related
M1S49_18860	COG0861	Integral membrane protein TerC family
M1S49_18870	COG0754	glutathionylspermidine amidase activity
M1S49_18880	COG0402	S-adenosylhomocysteine deaminase activity
M1S49_18895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S49_18900	COG1230	cation diffusion facilitator family transporter
M1S49_18915	COG0706	membrane insertase activity
M1S49_18955	COG0358	DNA primase activity
M1S49_19010	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S49_19055	COG0587	DNA-directed DNA polymerase activity
M1S49_19070	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S49_19070	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S49_19120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S49_19120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S49_19125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S49_19165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S49_19210	COG1309	transcriptional regulator
M1S49_19220	COG1902	pentaerythritol trinitrate reductase activity
M1S49_19230	COG1979	alcohol dehydrogenase
M1S49_19245	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S49_19270	COG1063	alcohol dehydrogenase
M1S49_19350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S49_19370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S49_19530	COG1192	Involved in chromosome partitioning
M1S49_19640	COG0484	heat shock protein binding
M1S49_19775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S49_19900	COG1525	nuclease