locus-tag	class	description
M1S58_00010	COG0592	DNA-directed DNA polymerase activity
M1S58_00020	COG0187	DNA topoisomerase II activity
M1S58_00030	COG0586	Pfam SNARE associated Golgi protein
M1S58_00035	COG0488	(ABC) transporter
M1S58_00060	COG0596	Alpha beta hydrolase
M1S58_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S58_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S58_00110	COG0733	neurotransmitter:sodium symporter activity
M1S58_00150	COG2233	PERMEase
M1S58_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S58_00200	COG2814	Major facilitator Superfamily
M1S58_00205	COG0656	L-ascorbic acid biosynthetic process
M1S58_00210	COG0583	DNA-binding transcription factor activity
M1S58_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S58_00230	COG1064	alcohol dehydrogenase
M1S58_00235	COG2818	Glycosylase
M1S58_00250	COG1194	a g-specific adenine glycosylase
M1S58_00270	COG2983	Belongs to the UPF0260 family
M1S58_00275	COG2133	pyrroloquinoline quinone binding
M1S58_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S58_00285	COG2116	formate transmembrane transporter activity
M1S58_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S58_00310	COG1335	isochorismatase
M1S58_00315	COG0385	Bile acid
M1S58_00320	COG0534	Mate efflux family protein
M1S58_00325	COG1683	Conserved Protein
M1S58_00345	COG0625	glutathione transferase activity
M1S58_00355	COG1113	amino acid transport
M1S58_00365	COG0523	cobalamin synthesis protein
M1S58_00375	COG2188	Transcriptional regulator
M1S58_00405	COG0010	Belongs to the arginase family
M1S58_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S58_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S58_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S58_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S58_00540	COG0534	Mate efflux family protein
M1S58_00545	COG0436	Aminotransferase
M1S58_00550	COG2733	membrane
M1S58_00565	COG2918	glutathione biosynthetic process
M1S58_00580	COG1388	LysM domain
M1S58_00580	COG0791	NLP P60 protein
M1S58_00595	COG3150	esterase
M1S58_00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S58_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S58_00630	COG2233	PERMEase
M1S58_00635	COG2351	hydroxyisourate hydrolase activity
M1S58_00670	COG3706	GGDEF domain
M1S58_00685	COG1393	Belongs to the ArsC family
M1S58_00690	COG0708	Exodeoxyribonuclease III
M1S58_00710	COG0189	ligase activity
M1S58_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S58_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S58_00755	COG4942	peptidase
M1S58_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S58_00775	COG2119	membrane
M1S58_00780	COG4774	siderophore transport
M1S58_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S58_00785	COG0426	domain, Protein
M1S58_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S58_00830	COG1902	pentaerythritol trinitrate reductase activity
M1S58_00835	COG1519	Transferase
M1S58_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S58_00845	COG0668	transmembrane transport
M1S58_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S58_00860	COG1335	isochorismatase
M1S58_00865	COG1522	sequence-specific DNA binding
M1S58_00870	COG3328	transposase activity
M1S58_00895	COG0784	Response regulator, receiver
M1S58_00895	COG2198	Histidine kinase
M1S58_00895	COG2205	protein histidine kinase activity
M1S58_00900	COG3162	membrane
M1S58_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S58_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S58_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S58_00940	COG1309	transcriptional regulator
M1S58_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S58_00960	COG0352	thiamine-phosphate diphosphorylase activity
M1S58_00960	COG0351	phosphomethylpyrimidine kinase
M1S58_00970	COG2814	Major facilitator Superfamily
M1S58_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S58_00995	COG1113	amino acid transport
M1S58_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S58_01010	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_01020	COG1335	isochorismatase
M1S58_01050	COG2814	Major facilitator Superfamily
M1S58_01055	COG0583	DNA-binding transcription factor activity
M1S58_01075	COG0667	Aldo Keto reductase
M1S58_01110	COG1733	regulation of RNA biosynthetic process
M1S58_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S58_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S58_01195	COG2329	Antibiotic biosynthesis monooxygenase
M1S58_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S58_01255	COG0427	acetyl-CoA hydrolase
M1S58_01280	COG0659	secondary active sulfate transmembrane transporter activity
M1S58_01285	COG4221	oxidoreductase activity
M1S58_01290	COG2873	o-acetylhomoserine
M1S58_01295	COG0488	(ABC) transporter
M1S58_01380	COG0833	amino acid
M1S58_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S58_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S58_01445	COG2226	methyltransferase
M1S58_01495	COG0067	glutamate synthase
M1S58_01495	COG0069	glutamate synthase activity
M1S58_01495	COG0070	glutamate synthase
M1S58_01500	COG0493	'glutamate synthase
M1S58_01510	COG1704	LemA family
M1S58_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S58_01535	COG3307	-O-antigen
M1S58_01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S58_01570	COG0194	GDP metabolic process
M1S58_01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S58_01640	COG5380	lipid catabolic process
M1S58_01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S58_01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S58_01675	COG0277	FAD linked oxidase domain protein
M1S58_01820	COG5410	chromosome segregation
M1S58_01940	COG0739	heme binding
M1S58_02010	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S58_02015	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S58_02050	COG0628	permease
M1S58_02055	COG1192	Involved in chromosome partitioning
M1S58_02085	COG0833	amino acid
M1S58_02090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S58_02095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S58_02105	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_02145	COG0583	DNA-binding transcription factor activity
M1S58_02190	COG0517	IMP dehydrogenase activity
M1S58_02195	COG1983	PspC domain protein
M1S58_02205	COG1960	acyl-CoA dehydrogenase activity
M1S58_02220	COG0408	coproporphyrinogen oxidase activity
M1S58_02240	COG0513	Belongs to the DEAD box helicase family
M1S58_02250	COG1127	ABC transporter
M1S58_02255	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S58_02265	COG2854	intermembrane phospholipid transfer
M1S58_02275	COG0598	Magnesium transport protein CorA
M1S58_02285	COG0494	nUDIX hydrolase
M1S58_02290	COG1040	competence protein
M1S58_02295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S58_02315	COG1946	Acyl-CoA thioesterase
M1S58_02320	COG1301	dicarboxylic acid transport
M1S58_02335	COG1959	2 iron, 2 sulfur cluster binding
M1S58_02340	COG1017	nitric oxide dioxygenase activity
M1S58_02340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S58_02345	COG0433	COG0433 Predicted ATPase
M1S58_02350	COG0626	cystathionine gamma-synthase activity
M1S58_02505	COG1960	acyl-CoA dehydrogenase activity
M1S58_02510	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S58_02540	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S58_02545	COG0339	signal peptide processing
M1S58_02550	COG0557	exoribonuclease II activity
M1S58_02595	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S58_02600	COG2169	Transcriptional regulator
M1S58_02605	COG0697	spore germination
M1S58_02610	COG1295	ribonuclease BN
M1S58_02645	COG1702	phosphate starvation-inducible protein PhoH
M1S58_02655	COG0739	heme binding
M1S58_02655	COG0741	lytic transglycosylase activity
M1S58_02655	COG1196	nuclear chromosome segregation
M1S58_02685	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S58_02690	COG1183	phosphatidylcholine synthase activity
M1S58_02735	COG1960	acyl-CoA dehydrogenase activity
M1S58_02740	COG1309	transcriptional regulator
M1S58_02755	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S58_02760	COG1960	acyl-CoA dehydrogenase activity
M1S58_02780	COG2969	positive regulation of protein catabolic process
M1S58_02790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S58_02805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S58_02810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S58_02830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S58_02840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S58_02845	COG1408	metallophosphoesterase
M1S58_02855	COG2199	diguanylate cyclase activity
M1S58_02915	COG1607	acyl-coa hydrolase
M1S58_02945	COG2350	Protein conserved in bacteria
M1S58_02955	COG0613	PHP domain protein
M1S58_02960	COG3781	membrane
M1S58_02970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S58_02975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S58_02985	COG1862	Preprotein translocase
M1S58_03035	COG0629	single-stranded DNA binding
M1S58_03105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S58_03235	COG4695	Portal protein
M1S58_03245	COG2205	protein histidine kinase activity
M1S58_03250	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S58_03280	COG0726	polysaccharide deacetylase
M1S58_03285	COG0463	Glycosyl transferase, family 2
M1S58_03290	COG0438	transferase activity, transferring glycosyl groups
M1S58_03355	COG0625	glutathione transferase activity
M1S58_03360	COG0583	DNA-binding transcription factor activity
M1S58_03365	COG1960	acyl-CoA dehydrogenase activity
M1S58_03370	COG1960	acyl-CoA dehydrogenase activity
M1S58_03380	COG2205	protein histidine kinase activity
M1S58_03385	COG0745	RESPONSE REGULATOR receiver
M1S58_03390	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S58_03410	COG2096	Adenosyltransferase
M1S58_03460	COG0285	dihydrofolate synthase activity
M1S58_03480	COG0450	alkyl hydroperoxide reductase
M1S58_03495	COG0477	Major facilitator Superfamily
M1S58_03500	COG1272	protein, Hemolysin III
M1S58_03530	COG0183	Belongs to the thiolase family
M1S58_03535	COG2207	Transcriptional regulator
M1S58_03555	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S58_03575	COG0183	Belongs to the thiolase family
M1S58_03585	COG2885	chlorophyll binding
M1S58_03585	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S58_03595	COG1690	Belongs to the RtcB family
M1S58_03600	COG0833	amino acid
M1S58_03610	COG2233	PERMEase
M1S58_03615	COG1217	gtp-binding protein TYPA
M1S58_03640	COG2094	Belongs to the DNA glycosylase MPG family
M1S58_03660	COG1902	pentaerythritol trinitrate reductase activity
M1S58_03675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S58_03680	COG0354	folic acid binding
M1S58_03690	COG3189	MarR family transcriptional regulator
M1S58_03695	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S58_03700	COG3422	double-strand break repair
M1S58_03740	COG0840	transmembrane signaling receptor activity
M1S58_03760	COG5510	response to toxic substance
M1S58_03770	COG2832	Protein of unknown function (DUF454)
M1S58_03775	COG1376	ErfK ybiS ycfS ynhG family protein
M1S58_03815	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S58_03825	COG1289	transmembrane transporter activity
M1S58_03830	COG2814	Major facilitator Superfamily
M1S58_03850	COG1115	amino acid carrier protein
M1S58_03855	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S58_03860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S58_03865	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S58_03895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S58_03905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S58_03910	COG1077	Cell shape determining protein MreB Mrl
M1S58_03915	COG1792	Involved in formation and maintenance of cell shape
M1S58_03920	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S58_03925	COG0424	maF-like protein
M1S58_03930	COG1530	ribonuclease E activity
M1S58_03940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S58_03950	COG0560	Phosphoserine phosphatase
M1S58_03960	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S58_03985	COG2207	Transcriptional regulator
M1S58_04005	COG1113	amino acid transport
M1S58_04010	COG2828	Protein conserved in bacteria
M1S58_04015	COG0142	geranyltranstransferase activity
M1S58_04020	COG2315	Protein conserved in bacteria
M1S58_04035	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S58_04055	COG2194	sulfuric ester hydrolase activity
M1S58_04060	COG0745	RESPONSE REGULATOR receiver
M1S58_04065	COG0642	Histidine kinase
M1S58_04075	COG0004	ammonium transporteR
M1S58_04080	COG0583	DNA-binding transcription factor activity
M1S58_04100	COG0525	valine-tRNA ligase activity
M1S58_04110	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_04120	COG0393	Putative heavy-metal-binding
M1S58_04125	COG0393	Putative heavy-metal-binding
M1S58_04130	COG1538	Outer membrane efflux protein
M1S58_04140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S58_04145	COG0671	phosphoesterase, PA-phosphatase related
M1S58_04175	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S58_04190	COG1648	precorrin-2 dehydrogenase activity
M1S58_04190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S58_04195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S58_04200	COG1733	regulation of RNA biosynthetic process
M1S58_04210	COG0531	amino acid
M1S58_04225	COG0321	lipoyl(octanoyl) transferase activity
M1S58_04230	COG2921	Belongs to the UPF0250 family
M1S58_04270	COG2009	succinate dehydrogenase
M1S58_04275	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S58_04280	COG1053	succinate dehydrogenase
M1S58_04285	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S58_04310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S58_04330	COG2354	Protein conserved in bacteria
M1S58_04335	COG2321	neutral zinc metallopeptidase
M1S58_04355	COG2843	Capsule synthesis protein
M1S58_04370	COG0589	response to stress
M1S58_04390	COG0505	Belongs to the CarA family
M1S58_04415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S58_04420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S58_04470	COG0477	Major facilitator Superfamily
M1S58_04475	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S58_04490	COG1597	lipid kinase activity
M1S58_04495	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S58_04525	COG0584	glycerophosphoryl diester phosphodiesterase
M1S58_04545	COG0741	lytic transglycosylase activity
M1S58_04565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S58_04580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S58_04615	COG0778	Nitroreductase
M1S58_04630	COG1929	Belongs to the glycerate kinase type-1 family
M1S58_04635	COG0243	molybdopterin cofactor binding
M1S58_04640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S58_04645	COG3339	Conserved Protein
M1S58_04655	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S58_04670	COG1113	amino acid transport
M1S58_04680	COG0019	diaminopimelate decarboxylase activity
M1S58_04690	COG1280	lysine exporter protein (LysE YggA)
M1S58_04695	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S58_04725	COG0463	Glycosyl transferase, family 2
M1S58_04745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S58_04780	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S58_04785	COG1136	(ABC) transporter
M1S58_04790	COG0658	competence protein
M1S58_04790	COG2333	competence protein COMEC
M1S58_04800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S58_04800	COG0616	signal peptide processing
M1S58_04805	COG0596	Alpha beta hydrolase
M1S58_04810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S58_04820	COG0628	permease
M1S58_04865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S58_04885	COG0823	Involved in the tonB-independent uptake of proteins
M1S58_04905	COG0824	Thioesterase
M1S58_04910	COG1473	amidohydrolase
M1S58_04930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S58_04930	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S58_04935	COG2814	Major facilitator Superfamily
M1S58_04945	COG1024	Enoyl-CoA hydratase
M1S58_04950	COG1051	belongs to the nudix hydrolase family
M1S58_04950	COG1056	cytidyltransferase-related domain
M1S58_04960	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S58_04975	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S58_04990	COG4625	pathogenesis
M1S58_04995	COG0583	DNA-binding transcription factor activity
M1S58_05000	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S58_05005	COG4208	sulfate ABC transporter
M1S58_05010	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S58_05020	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S58_05025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S58_05030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S58_05050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S58_05065	COG0681	Belongs to the peptidase S26 family
M1S58_05080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S58_05090	COG1381	Involved in DNA repair and RecF pathway recombination
M1S58_05095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S58_05135	COG0436	Aminotransferase
M1S58_05155	COG0556	nucleotide-excision repair
M1S58_05210	COG2070	2-Nitropropane dioxygenase
M1S58_05240	COG1215	transferase activity, transferring glycosyl groups
M1S58_05255	COG0415	Belongs to the DNA photolyase family
M1S58_05265	COG1252	NADH dehydrogenase
M1S58_05270	COG1686	Belongs to the peptidase S11 family
M1S58_05285	COG1187	pseudouridine synthase activity
M1S58_05310	COG0477	Major facilitator Superfamily
M1S58_05315	COG0583	DNA-binding transcription factor activity
M1S58_05320	COG1823	symporter activity
M1S58_05330	COG0612	Peptidase, M16
M1S58_05355	COG0352	thiamine-phosphate diphosphorylase activity
M1S58_05390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S58_05405	COG1309	transcriptional regulator
M1S58_05415	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S58_05420	COG0076	glutamate decarboxylase activity
M1S58_05430	COG1522	sequence-specific DNA binding
M1S58_05435	COG3961	Belongs to the TPP enzyme family
M1S58_05440	COG1113	amino acid transport
M1S58_05445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S58_05450	COG0573	inorganic phosphate transmembrane transporter activity
M1S58_05460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S58_05465	COG0616	signal peptide processing
M1S58_05500	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S58_05505	COG1686	Belongs to the peptidase S11 family
M1S58_05530	COG0583	DNA-binding transcription factor activity
M1S58_05535	COG1067	ATP-dependent peptidase activity
M1S58_05580	COG1966	Carbon starvation protein
M1S58_05585	COG2879	small protein
M1S58_05620	COG2508	Transcriptional regulator
M1S58_05620	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S58_05640	COG1113	amino acid transport
M1S58_05645	COG0583	DNA-binding transcription factor activity
M1S58_05650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S58_05655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S58_05665	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_05675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S58_05680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S58_05680	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S58_05715	COG2814	Major facilitator Superfamily
M1S58_05720	COG4948	Mandelate Racemase Muconate Lactonizing
M1S58_05730	COG1309	transcriptional regulator
M1S58_05750	COG1741	Belongs to the pirin family
M1S58_05760	COG2964	Protein conserved in bacteria
M1S58_05775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S58_05780	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S58_05785	COG4605	iron ion homeostasis
M1S58_05790	COG4604	ABC transporter, ATP-binding protein
M1S58_05795	COG4607	ABC-type enterochelin transport system periplasmic component
M1S58_05800	COG4774	siderophore transport
M1S58_05810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S58_05815	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S58_05820	COG1535	isochorismatase
M1S58_05820	COG3433	isochorismatase activity
M1S58_05835	COG1132	(ABC) transporter
M1S58_05840	COG1132	(ABC) transporter
M1S58_05845	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S58_05855	COG1169	isochorismate synthase
M1S58_05870	COG3739	integral membrane protein
M1S58_05895	COG0302	gtp cyclohydrolase
M1S58_05905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S58_05935	COG0308	aminopeptidase N
M1S58_05940	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S58_05955	COG0174	glutamine synthetase
M1S58_05965	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S58_06000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S58_06005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S58_06010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S58_06030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S58_06035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S58_06040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S58_06055	COG1960	acyl-CoA dehydrogenase activity
M1S58_06060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S58_06065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S58_06075	COG2223	nitrite transmembrane transporter activity
M1S58_06085	COG0024	Methionine aminopeptidase
M1S58_06090	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S58_06105	COG2207	Transcriptional regulator
M1S58_06130	COG2951	lytic endotransglycosylase activity
M1S58_06135	COG0772	Belongs to the SEDS family
M1S58_06150	COG0842	Transport permease protein
M1S58_06155	COG1131	(ABC) transporter
M1S58_06200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S58_06215	COG4215	(ABC) transporter
M1S58_06220	COG4160	amino acid transport
M1S58_06225	COG4598	ABC transporter
M1S58_06235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S58_06240	COG0826	peptidase U32
M1S58_06245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S58_06260	COG1720	tRNA m6t6A37 methyltransferase activity
M1S58_06270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S58_06285	COG0642	Histidine kinase
M1S58_06295	COG0494	nUDIX hydrolase
M1S58_06305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S58_06310	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S58_06315	COG3139	Protein of unknown function (DUF1315)
M1S58_06320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S58_06325	COG1301	dicarboxylic acid transport
M1S58_06330	COG1960	acyl-CoA dehydrogenase activity
M1S58_06335	COG2819	hydrolase of the alpha beta superfamily
M1S58_06345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S58_06355	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S58_06360	COG1234	tRNA 3'-trailer cleavage
M1S58_06390	COG2363	Small membrane protein
M1S58_06415	COG0513	Belongs to the DEAD box helicase family
M1S58_06425	COG0778	Nitroreductase
M1S58_06455	COG1286	toxin biosynthetic process
M1S58_06480	COG4783	chaperone-mediated protein folding
M1S58_06485	COG1610	YqeY-like protein
M1S58_06585	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S58_06610	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S58_06615	COG0786	glutamate:sodium symporter activity
M1S58_06625	COG2186	Transcriptional regulator
M1S58_06675	COG0477	Major facilitator Superfamily
M1S58_06705	COG2985	domain, Protein
M1S58_06715	COG2995	paraquat-inducible protein a
M1S58_06720	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M1S58_06720	COG3008	intermembrane lipid transfer
M1S58_06730	COG1794	racemase activity, acting on amino acids and derivatives
M1S58_06820	COG0488	(ABC) transporter
M1S58_06825	COG3173	Aminoglycoside phosphotransferase
M1S58_06835	COG2433	Pfam Transposase IS66
M1S58_06875	COG1301	dicarboxylic acid transport
M1S58_06885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S58_06890	COG2011	ABC-type metal ion transport system permease component
M1S58_06895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S58_06900	COG1464	Belongs to the NlpA lipoprotein family
M1S58_06905	COG0151	Belongs to the GarS family
M1S58_06910	COG0138	bifunctional purine biosynthesis protein purh
M1S58_06915	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S58_06945	COG2308	Evidence 4 Homologs of previously reported genes of
M1S58_06955	COG1305	Transglutaminase-like
M1S58_06965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S58_06970	COG0305	Participates in initiation and elongation during chromosome replication
M1S58_06995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S58_07005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S58_07010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S58_07035	COG0726	polysaccharide deacetylase
M1S58_07035	COG1649	PFAM Uncharacterised BCR, COG1649
M1S58_07040	COG1215	transferase activity, transferring glycosyl groups
M1S58_07045	COG3658	cytochrome
M1S58_07055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S58_07070	COG0583	DNA-binding transcription factor activity
M1S58_07090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S58_07095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S58_07110	COG1960	acyl-CoA dehydrogenase activity
M1S58_07115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S58_07120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S58_07145	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S58_07150	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S58_07160	COG2205	protein histidine kinase activity
M1S58_07165	COG0745	RESPONSE REGULATOR receiver
M1S58_07170	COG0174	glutamine synthetase
M1S58_07190	COG0729	surface antigen
M1S58_07215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S58_07220	COG2814	Major facilitator Superfamily
M1S58_07235	COG0583	DNA-binding transcription factor activity
M1S58_07250	COG1187	pseudouridine synthase activity
M1S58_07270	COG0802	atpase or kinase
M1S58_07275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S58_07285	COG1923	regulation of RNA biosynthetic process
M1S58_07290	COG0697	spore germination
M1S58_07305	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S58_07315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S58_07320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S58_07320	COG0519	Catalyzes the synthesis of GMP from XMP
M1S58_07325	COG4302	ethanolamine ammonia-lyase activity
M1S58_07330	COG4303	Ethanolamine ammonia lyase large subunit
M1S58_07335	COG0531	amino acid
M1S58_07355	COG1454	alcohol dehydrogenase
M1S58_07360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S58_07370	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S58_07390	COG0308	aminopeptidase N
M1S58_07400	COG4221	oxidoreductase activity
M1S58_07410	COG1605	Chorismate mutase
M1S58_07430	COG1309	transcriptional regulator
M1S58_07440	COG0668	transmembrane transport
M1S58_07475	COG4773	Receptor
M1S58_07495	COG0488	(ABC) transporter
M1S58_07500	COG0589	response to stress
M1S58_07525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S58_07535	COG3135	benzoate transporter
M1S58_07540	COG1522	sequence-specific DNA binding
M1S58_07550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S58_07555	COG0583	DNA-binding transcription factor activity
M1S58_07565	COG0183	Belongs to the thiolase family
M1S58_07575	COG2030	dehydratase
M1S58_07580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S58_07595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S58_07605	COG0824	Thioesterase
M1S58_07610	COG1454	alcohol dehydrogenase
M1S58_07620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S58_07640	COG0069	glutamate synthase activity
M1S58_07715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S58_07720	COG4197	protein conserved in bacteria, prophage-related
M1S58_07975	COG2814	Major facilitator Superfamily
M1S58_07990	COG0511	ligase activity, forming carbon-carbon bonds
M1S58_08010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S58_08010	COG1116	anion transmembrane transporter activity
M1S58_08015	COG0745	RESPONSE REGULATOR receiver
M1S58_08025	COG2146	nitrite reductase [NAD(P)H] activity
M1S58_08025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S58_08030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S58_08035	COG0243	molybdopterin cofactor binding
M1S58_08045	COG0243	molybdopterin cofactor binding
M1S58_08050	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S58_08065	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S58_08065	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S58_08070	COG0303	'Molybdopterin
M1S58_08080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S58_08085	COG0697	spore germination
M1S58_08105	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S58_08110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S58_08165	COG2204	response regulator
M1S58_08170	COG3852	Histidine kinase
M1S58_08190	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S58_08195	COG0575	Belongs to the CDS family
M1S58_08230	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S58_08245	COG2137	regulation of response to DNA damage stimulus
M1S58_08255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S58_08260	COG1011	Hydrolase
M1S58_08285	COG1522	sequence-specific DNA binding
M1S58_08295	COG1113	amino acid transport
M1S58_08315	COG0659	secondary active sulfate transmembrane transporter activity
M1S58_08320	COG2135	peptidase activity
M1S58_08335	COG3300	MHYT domain
M1S58_08335	COG5001	Diguanylate cyclase
M1S58_08355	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S58_08355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S58_08355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S58_08360	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S58_08365	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S58_08365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S58_08395	COG0024	Methionine aminopeptidase
M1S58_08400	COG0583	DNA-binding transcription factor activity
M1S58_08410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S58_08415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S58_08420	COG0517	IMP dehydrogenase activity
M1S58_08420	COG0516	GMP reductase activity
M1S58_08445	COG0552	protein localization to endoplasmic reticulum
M1S58_08455	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S58_08470	COG4890	Cyd operon protein YbgT
M1S58_08475	COG1294	oxidase, subunit
M1S58_08490	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S58_08500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S58_08505	COG4774	siderophore transport
M1S58_08520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S58_08525	COG0569	domain protein
M1S58_08530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S58_08560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S58_08565	COG0542	response to heat
M1S58_08590	COG1902	pentaerythritol trinitrate reductase activity
M1S58_08590	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S58_08635	COG2323	membrane
M1S58_08640	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S58_08650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S58_08655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S58_08660	COG0183	Belongs to the thiolase family
M1S58_08665	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S58_08670	COG0596	Alpha beta hydrolase
M1S58_08675	COG2271	Major facilitator Superfamily
M1S58_08680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S58_08685	COG3485	protocatechuate 3,4-dioxygenase
M1S58_08690	COG3485	protocatechuate 3,4-dioxygenase
M1S58_08695	COG0710	3-dehydroquinate dehydratase activity
M1S58_08700	COG3420	alginic acid biosynthetic process
M1S58_08705	COG3659	wide pore channel activity
M1S58_08710	COG4993	Dehydrogenase
M1S58_08720	COG2391	methyltransferase activity
M1S58_08735	COG1414	Transcriptional regulator
M1S58_08740	COG0583	DNA-binding transcription factor activity
M1S58_08745	COG1960	acyl-CoA dehydrogenase activity
M1S58_08770	COG2814	Major facilitator Superfamily
M1S58_08780	COG0154	amidase activity
M1S58_08800	COG4638	Rieske (2fe-2S)
M1S58_08810	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_08820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S58_08830	COG3733	amine oxidase
M1S58_08840	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_08850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S58_08855	COG0183	Belongs to the thiolase family
M1S58_08860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S58_08865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S58_08875	COG4829	muconolactone delta-isomerase
M1S58_08880	COG4948	Mandelate Racemase Muconate Lactonizing
M1S58_08885	COG0583	DNA-binding transcription factor activity
M1S58_08895	COG2186	Transcriptional regulator
M1S58_08915	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_08935	COG1960	acyl-CoA dehydrogenase activity
M1S58_08940	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_08945	COG3829	transcription factor binding
M1S58_08955	COG3162	membrane
M1S58_08970	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_08985	COG0753	catalase activity
M1S58_09005	COG1846	Transcriptional regulator
M1S58_09010	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S58_09010	COG1902	pentaerythritol trinitrate reductase activity
M1S58_09020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S58_09050	COG1309	transcriptional regulator
M1S58_09060	COG1335	isochorismatase
M1S58_09065	COG0583	DNA-binding transcription factor activity
M1S58_09075	COG0475	glutathione-regulated potassium exporter activity
M1S58_09075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S58_09085	COG1473	amidohydrolase
M1S58_09095	COG2831	hemolysin activation secretion protein
M1S58_09100	COG3210	domain, Protein
M1S58_09130	COG2188	Transcriptional regulator
M1S58_09145	COG0583	DNA-binding transcription factor activity
M1S58_09205	COG1566	PFAM secretion protein HlyD family protein
M1S58_09220	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_09225	COG0129	dihydroxy-acid dehydratase activity
M1S58_09235	COG0583	DNA-binding transcription factor activity
M1S58_09240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S58_09250	COG2084	Dehydrogenase
M1S58_09255	COG2207	Transcriptional regulator
M1S58_09270	COG1064	alcohol dehydrogenase
M1S58_09280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S58_09285	COG1120	ATPase activity
M1S58_09305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S58_09425	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S58_09475	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_09490	COG2207	Transcriptional regulator
M1S58_09500	COG2205	protein histidine kinase activity
M1S58_09505	COG0745	RESPONSE REGULATOR receiver
M1S58_09510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S58_09515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S58_09520	COG1538	Outer membrane efflux protein
M1S58_09530	COG2072	flavoprotein involved in K transport
M1S58_09550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S58_09570	COG3539	Fimbrial protein
M1S58_09600	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S58_09610	COG0753	catalase activity
M1S58_09625	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S58_09685	COG1535	isochorismatase
M1S58_09685	COG3433	isochorismatase activity
M1S58_09690	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_09695	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S58_09700	COG4149	molybdate abc transporter
M1S58_09705	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S58_09715	COG4638	Rieske (2fe-2S)
M1S58_09720	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S58_09725	COG0543	2 iron, 2 sulfur cluster binding
M1S58_09725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S58_09750	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_09765	COG2207	Transcriptional regulator
M1S58_09775	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_09780	COG2610	gluconate transmembrane transporter activity
M1S58_09790	COG0583	DNA-binding transcription factor activity
M1S58_09800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S58_09805	COG2031	fatty acid transporter
M1S58_09810	COG0183	Belongs to the thiolase family
M1S58_09815	COG0583	DNA-binding transcription factor activity
M1S58_09820	COG0583	DNA-binding transcription factor activity
M1S58_09835	COG1027	Aspartate ammonia-lyase
M1S58_09845	COG0477	Major facilitator Superfamily
M1S58_09865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S58_09870	COG4521	taurine ABC transporter
M1S58_09885	COG2188	Transcriptional regulator
M1S58_09895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S58_09900	COG1733	regulation of RNA biosynthetic process
M1S58_09905	COG2207	Transcriptional regulator
M1S58_09905	COG3708	Transcriptional regulator
M1S58_09920	COG0730	response to heat
M1S58_09935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S58_09935	COG3453	Protein conserved in bacteria
M1S58_09945	COG3781	membrane
M1S58_09950	COG1063	alcohol dehydrogenase
M1S58_09960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S58_09965	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S58_09970	COG0022	dehydrogenase e1 component
M1S58_09975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S58_09980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S58_09995	COG3706	GGDEF domain
M1S58_10010	COG0133	tryptophan synthase activity
M1S58_10020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S58_10055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S58_10080	COG2226	methyltransferase
M1S58_10135	COG0842	Transport permease protein
M1S58_10140	COG0842	Transport permease protein
M1S58_10145	COG1131	(ABC) transporter
M1S58_10160	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S58_10165	COG4773	Receptor
M1S58_10185	COG0730	response to heat
M1S58_10190	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S58_10210	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S58_10225	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S58_10265	COG4264	IucA IucC family
M1S58_10270	COG4264	IucA IucC family
M1S58_10290	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S58_10305	COG1960	acyl-CoA dehydrogenase activity
M1S58_10310	COG1960	acyl-CoA dehydrogenase activity
M1S58_10315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S58_10320	COG2207	Transcriptional regulator
M1S58_10325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S58_10330	COG0776	regulation of translation
M1S58_10355	COG0822	iron-sulfur transferase activity
M1S58_10360	COG0316	Belongs to the HesB IscA family
M1S58_10390	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S58_10410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S58_10415	COG0702	epimerase
M1S58_10450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S58_10460	COG0339	signal peptide processing
M1S58_10510	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S58_10515	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S58_10545	COG0776	regulation of translation
M1S58_10610	COG0084	hydrolase, TatD family'
M1S58_10630	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S58_10635	COG1132	(ABC) transporter
M1S58_10645	COG0811	peptide transport
M1S58_10650	COG1475	DNA binding
M1S58_10655	COG1192	Involved in chromosome partitioning
M1S58_10665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S58_10680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S58_10685	COG0191	fructose-bisphosphate aldolase activity
M1S58_10705	COG0424	maF-like protein
M1S58_10710	COG2850	peptidyl-arginine hydroxylation
M1S58_10720	COG0640	Transcriptional regulator
M1S58_10730	COG3619	membrane
M1S58_10735	COG3122	Protein conserved in bacteria
M1S58_10740	COG1132	(ABC) transporter
M1S58_10760	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S58_10765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S58_10775	COG0506	proline dehydrogenase activity
M1S58_10775	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S58_10775	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S58_10780	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S58_10795	COG3698	Phosphodiester glycosidase
M1S58_10805	COG2353	YceI-like domain
M1S58_10815	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S58_10865	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S58_10865	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S58_10890	COG3539	Fimbrial protein
M1S58_10895	COG3121	Chaperone
M1S58_10920	COG0697	spore germination
M1S58_10940	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S58_10950	COG0583	DNA-binding transcription factor activity
M1S58_10970	COG1309	transcriptional regulator
M1S58_10985	COG1522	sequence-specific DNA binding
M1S58_10995	COG1126	abc transporter atp-binding protein
M1S58_11000	COG0765	amino acid transport
M1S58_11005	COG0765	amino acid transport
M1S58_11035	COG1464	Belongs to the NlpA lipoprotein family
M1S58_11045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S58_11050	COG2011	ABC-type metal ion transport system permease component
M1S58_11055	COG0012	GTP binding
M1S58_11080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S58_11120	COG0386	Belongs to the glutathione peroxidase family
M1S58_11130	COG0436	Aminotransferase
M1S58_11185	COG0583	DNA-binding transcription factor activity
M1S58_11190	COG0798	PFAM Bile acid sodium symporter
M1S58_11195	COG0640	Transcriptional regulator
M1S58_11210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S58_11220	COG0583	DNA-binding transcription factor activity
M1S58_11230	COG1953	Uracil, thiamine, allantoin
M1S58_11240	COG2175	clavaminate synthase activity
M1S58_11245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S58_11250	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S58_11255	COG4521	taurine ABC transporter
M1S58_11265	COG0477	Major facilitator Superfamily
M1S58_11285	COG1271	oxidase subunit
M1S58_11290	COG1294	oxidase, subunit
M1S58_11300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S58_11320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S58_11340	COG3052	prosthetic group binding
M1S58_11345	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S58_11355	COG2814	Major facilitator Superfamily
M1S58_11375	COG1346	cytolysis
M1S58_11385	COG0583	DNA-binding transcription factor activity
M1S58_11390	COG0625	glutathione transferase activity
M1S58_11395	COG0625	glutathione transferase activity
M1S58_11400	COG0583	DNA-binding transcription factor activity
M1S58_11415	COG1045	serine acetyltransferase
M1S58_11420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S58_11425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S58_11435	COG1280	lysine exporter protein (LysE YggA)
M1S58_11450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S58_11455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S58_11460	COG1126	abc transporter atp-binding protein
M1S58_11465	COG0765	amino acid transport
M1S58_11470	COG0765	amino acid transport
M1S58_11490	COG2205	protein histidine kinase activity
M1S58_11490	COG0784	Response regulator, receiver
M1S58_11510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S58_11530	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_11580	COG0583	DNA-binding transcription factor activity
M1S58_11600	COG0318	PFAM AMP-dependent synthetase and ligase
M1S58_11605	COG1309	transcriptional regulator
M1S58_11610	COG1960	acyl-CoA dehydrogenase activity
M1S58_11615	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S58_11620	COG1024	Enoyl-CoA hydratase
M1S58_11625	COG4770	biotin carboxylase activity
M1S58_11635	COG0583	DNA-binding transcription factor activity
M1S58_11650	COG1960	acyl-CoA dehydrogenase activity
M1S58_11660	COG2814	Major facilitator Superfamily
M1S58_11670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S58_11675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S58_11680	COG2814	Major facilitator Superfamily
M1S58_11685	COG1960	acyl-CoA dehydrogenase activity
M1S58_11690	COG1024	Enoyl-CoA hydratase
M1S58_11695	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_11700	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S58_11705	COG0183	Belongs to the thiolase family
M1S58_11715	COG2814	Major facilitator Superfamily
M1S58_11725	COG1024	Enoyl-CoA hydratase
M1S58_11740	COG1960	acyl-CoA dehydrogenase activity
M1S58_11745	COG2814	Major facilitator Superfamily
M1S58_11750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S58_11755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S58_11770	COG3842	ATPase activity
M1S58_11775	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S58_11785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S58_11790	COG1414	Transcriptional regulator
M1S58_11800	COG0583	DNA-binding transcription factor activity
M1S58_11805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S58_11810	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_11820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S58_11830	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_11835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S58_11840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S58_11845	COG2267	carboxylic ester hydrolase activity
M1S58_11865	COG3038	cytochrome b561
M1S58_11870	COG0753	catalase activity
M1S58_11905	COG2050	protein possibly involved in aromatic compounds catabolism
M1S58_11915	COG3327	negative regulation of DNA-templated transcription, initiation
M1S58_11920	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S58_11925	COG0183	Belongs to the thiolase family
M1S58_11930	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S58_11935	COG1024	Enoyl-CoA hydratase
M1S58_11940	COG1024	Enoyl-CoA hydratase
M1S58_11945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S58_11950	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S58_11955	COG3396	Phenylacetate-CoA oxygenase
M1S58_11960	COG3460	Phenylacetate-CoA oxygenase
M1S58_11965	COG3396	Phenylacetate-CoA oxygenase
M1S58_11970	COG2030	dehydratase
M1S58_11970	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_11975	COG1760	l-serine dehydratase
M1S58_11980	COG0531	amino acid
M1S58_11985	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_12000	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S58_12010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S58_12030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S58_12040	COG0789	Transcriptional regulator
M1S58_12055	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S58_12070	COG2807	transmembrane transport
M1S58_12075	COG0590	tRNA wobble adenosine to inosine editing
M1S58_12195	COG1116	anion transmembrane transporter activity
M1S58_12200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S58_12210	COG0864	Transcriptional regulator
M1S58_12230	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S58_12235	COG0439	Biotin carboxylase
M1S58_12250	COG1063	alcohol dehydrogenase
M1S58_12260	COG1309	transcriptional regulator
M1S58_12280	COG0038	chloride channel
M1S58_12285	COG4770	biotin carboxylase activity
M1S58_12305	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S58_12310	COG0583	DNA-binding transcription factor activity
M1S58_12360	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S58_12380	COG2814	Major facilitator Superfamily
M1S58_12395	COG1560	Kdo2-lipid A biosynthetic process
M1S58_12405	COG5006	permease, DMT superfamily
M1S58_12410	COG1522	sequence-specific DNA binding
M1S58_12425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S58_12435	COG4122	O-methyltransferase activity
M1S58_12465	COG1538	Outer membrane efflux protein
M1S58_12470	COG1137	ATPase activity
M1S58_12475	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S58_12485	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S58_12490	COG0517	IMP dehydrogenase activity
M1S58_12490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S58_12525	COG2814	Major facilitator Superfamily
M1S58_12560	COG1278	Cold shock
M1S58_12565	COG1280	lysine exporter protein (LysE YggA)
M1S58_12595	COG1570	exodeoxyribonuclease VII activity
M1S58_12645	COG0583	DNA-binding transcription factor activity
M1S58_12655	COG4638	Rieske (2fe-2S)
M1S58_12660	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S58_12665	COG0633	Ferredoxin
M1S58_12665	COG0543	2 iron, 2 sulfur cluster binding
M1S58_12670	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_12675	COG3135	benzoate transporter
M1S58_12680	COG2814	Major facilitator Superfamily
M1S58_12695	COG1643	Atp-dependent helicase
M1S58_12700	COG0450	alkyl hydroperoxide reductase
M1S58_12710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S58_12720	COG3634	alkyl hydroperoxide reductase activity
M1S58_12740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S58_12745	COG0625	glutathione transferase activity
M1S58_12755	COG2885	chlorophyll binding
M1S58_12790	COG0542	response to heat
M1S58_12805	COG1765	OsmC-like protein
M1S58_12840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S58_12850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S58_12860	COG0527	aspartate kinase activity
M1S58_12870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S58_12880	COG3038	cytochrome b561
M1S58_12885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S58_12890	COG2252	PERMEase
M1S58_12900	COG2072	flavoprotein involved in K transport
M1S58_12915	COG1741	Belongs to the pirin family
M1S58_12920	COG1309	transcriptional regulator
M1S58_12930	COG0300	oxidoreductase activity
M1S58_13040	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S58_13120	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_13140	COG0531	amino acid
M1S58_13150	COG1113	amino acid transport
M1S58_13190	COG3209	COG3209 Rhs family protein
M1S58_13220	COG4269	membrane
M1S58_13235	COG1902	pentaerythritol trinitrate reductase activity
M1S58_13235	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S58_13245	COG2203	Gaf domain
M1S58_13245	COG3706	GGDEF domain
M1S58_13245	COG4251	negative regulation of phosphorylation
M1S58_13245	COG5001	Diguanylate cyclase
M1S58_13255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S58_13275	COG4172	Belongs to the ABC transporter superfamily
M1S58_13280	COG4239	(ABC) transporter, permease
M1S58_13285	COG4174	ABC transporter (Permease)
M1S58_13295	COG1388	LysM domain
M1S58_13295	COG0741	lytic transglycosylase activity
M1S58_13295	COG1388	LysM domain
M1S58_13295	COG0741	lytic transglycosylase activity
M1S58_13300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S58_13340	COG0583	DNA-binding transcription factor activity
M1S58_13345	COG1279	arginine transmembrane transporter activity
M1S58_13365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S58_13370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S58_13375	COG0006	proline dipeptidase activity
M1S58_13415	COG2194	sulfuric ester hydrolase activity
M1S58_13460	COG0739	heme binding
M1S58_13785	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S58_13810	COG3384	dioxygenase
M1S58_13820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S58_13825	COG2878	Part of a membrane complex involved in electron transport
M1S58_13830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S58_13855	COG0768	penicillin binding
M1S58_13860	COG0742	ribosomal rna small subunit methyltransferase
M1S58_13875	COG0830	nickel cation binding
M1S58_13885	COG0804	urea catabolic process
M1S58_13925	COG1253	flavin adenine dinucleotide binding
M1S58_13930	COG2851	Citrate transporter
M1S58_13980	COG1773	rubredoxin
M1S58_13985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S58_13995	COG0583	DNA-binding transcription factor activity
M1S58_14020	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S58_14025	COG4181	ATPase activity
M1S58_14070	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S58_14090	COG0306	phosphate transporter
M1S58_14100	COG3958	Transketolase
M1S58_14105	COG3959	Transketolase, thiamine diphosphate binding domain
M1S58_14110	COG2271	Major facilitator Superfamily
M1S58_14115	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_14120	COG0583	DNA-binding transcription factor activity
M1S58_14135	COG2223	nitrite transmembrane transporter activity
M1S58_14140	COG2207	Transcriptional regulator
M1S58_14145	COG2066	Belongs to the glutaminase family
M1S58_14150	COG0242	peptide deformylase activity
M1S58_14155	COG0477	Major facilitator Superfamily
M1S58_14165	COG0028	Belongs to the TPP enzyme family
M1S58_14180	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_14185	COG2267	carboxylic ester hydrolase activity
M1S58_14195	COG2271	Major facilitator Superfamily
M1S58_14200	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S58_14210	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_14230	COG1414	Transcriptional regulator
M1S58_14245	COG1024	Enoyl-CoA hydratase
M1S58_14255	COG1215	transferase activity, transferring glycosyl groups
M1S58_14260	COG0726	polysaccharide deacetylase
M1S58_14260	COG1649	PFAM Uncharacterised BCR, COG1649
M1S58_14270	COG4681	YaeQ
M1S58_14280	COG0523	cobalamin synthesis protein
M1S58_14290	COG1607	acyl-coa hydrolase
M1S58_14300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S58_14305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S58_14310	COG1309	transcriptional regulator
M1S58_14335	COG2040	homocysteine
M1S58_14340	COG0531	amino acid
M1S58_14365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S58_14370	COG0477	Major facilitator Superfamily
M1S58_14430	COG1061	Type III restriction enzyme res subunit
M1S58_14440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S58_14445	COG1192	Involved in chromosome partitioning
M1S58_14455	COG1061	Type III restriction enzyme res subunit
M1S58_14545	COG0592	DNA-directed DNA polymerase activity
M1S58_14585	COG2026	Addiction module toxin, RelE StbE family
M1S58_14735	COG3755	Protein conserved in bacteria
M1S58_14780	COG1484	DNA-dependent DNA replication
M1S58_14870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S58_14940	COG0405	Gamma-glutamyltransferase
M1S58_14945	COG2814	Major facilitator Superfamily
M1S58_14955	COG2050	protein possibly involved in aromatic compounds catabolism
M1S58_14970	COG1090	epimerase
M1S58_14990	COG0420	3'-5' exonuclease activity
M1S58_15015	COG0735	belongs to the Fur family
M1S58_15020	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S58_15040	COG0121	glutamine amidotransferase
M1S58_15055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S58_15065	COG0210	DNA helicase
M1S58_15070	COG2885	chlorophyll binding
M1S58_15075	COG0204	Acyl-transferase
M1S58_15090	COG2894	cell division
M1S58_15115	COG1280	lysine exporter protein (LysE YggA)
M1S58_15120	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S58_15120	COG1674	ftsk spoiiie
M1S58_15125	COG0492	ferredoxin-NADP+ reductase activity
M1S58_15130	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S58_15140	COG0456	acetyltransferase
M1S58_15185	COG1981	membrane
M1S58_15200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S58_15200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S58_15220	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_15230	COG0657	acetylesterase activity
M1S58_15240	COG0473	3-isopropylmalate dehydrogenase activity
M1S58_15245	COG0583	DNA-binding transcription factor activity
M1S58_15265	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S58_15290	COG0564	pseudouridine synthase activity
M1S58_15300	COG0358	DNA primase activity
M1S58_15315	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S58_15345	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S58_15375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S58_15385	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S58_15385	COG0352	thiamine-phosphate diphosphorylase activity
M1S58_15385	COG0351	phosphomethylpyrimidine kinase
M1S58_15390	COG1652	LysM domain
M1S58_15415	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S58_15420	COG3101	peptidyl-lysine hydroxylation
M1S58_15425	COG0009	L-threonylcarbamoyladenylate synthase
M1S58_15430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S58_15435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S58_15450	COG4106	trans-aconitate 2-methyltransferase activity
M1S58_15465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S58_15465	COG2226	methyltransferase
M1S58_15465	COG0596	Alpha beta hydrolase
M1S58_15470	COG1877	trehalose-phosphatase activity
M1S58_15475	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S58_15480	COG2223	nitrite transmembrane transporter activity
M1S58_15500	COG1196	nuclear chromosome segregation
M1S58_15510	COG0730	response to heat
M1S58_15525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S58_15535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S58_15585	COG0489	protein tyrosine kinase activity
M1S58_15595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S58_15595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S58_15625	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S58_15630	COG2081	HI0933 family
M1S58_15640	COG0668	transmembrane transport
M1S58_15660	COG0583	DNA-binding transcription factor activity
M1S58_15680	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S58_15685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S58_15715	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S58_15755	COG0745	RESPONSE REGULATOR receiver
M1S58_15775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S58_15785	COG2205	protein histidine kinase activity
M1S58_15855	COG4993	Dehydrogenase
M1S58_15880	COG0384	phenazine biosynthesis protein PhzF
M1S58_15905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S58_15920	COG0583	DNA-binding transcription factor activity
M1S58_15950	COG0583	DNA-binding transcription factor activity
M1S58_15965	COG0583	DNA-binding transcription factor activity
M1S58_15970	COG1053	succinate dehydrogenase
M1S58_15980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S58_15985	COG2814	Major facilitator Superfamily
M1S58_15990	COG1960	acyl-CoA dehydrogenase activity
M1S58_15995	COG0583	DNA-binding transcription factor activity
M1S58_16000	COG1063	alcohol dehydrogenase
M1S58_16030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S58_16035	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S58_16040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S58_16055	COG3667	copper resistance
M1S58_16060	COG2132	Multicopper oxidase
M1S58_16070	COG0561	phosphatase activity
M1S58_16075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S58_16100	COG1214	PFAM Peptidase M22, glycoprotease
M1S58_16160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S58_16165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S58_16170	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S58_16230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S58_16240	COG1846	Transcriptional regulator
M1S58_16245	COG1764	response to oxidative stress
M1S58_16285	COG0037	tRNA processing
M1S58_16295	COG0248	Ppx GppA phosphatase
M1S58_16325	COG0072	phenylalanine-tRNA ligase activity
M1S58_16370	COG1238	metal cluster binding
M1S58_16375	COG0625	glutathione transferase activity
M1S58_16390	COG0318	PFAM AMP-dependent synthetase and ligase
M1S58_16395	COG3028	Belongs to the UPF0307 family
M1S58_16400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S58_16420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S58_16425	COG0617	tRNA 3'-terminal CCA addition
M1S58_16430	COG1555	photosystem II stabilization
M1S58_16435	COG3956	TIGRFAM MazG family protein
M1S58_16445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S58_16465	COG0784	Response regulator, receiver
M1S58_16465	COG2205	protein histidine kinase activity
M1S58_16465	COG5002	protein histidine kinase activity
M1S58_16470	COG1024	Enoyl-CoA hydratase
M1S58_16475	COG2084	Dehydrogenase
M1S58_16480	COG3622	Belongs to the hyi family
M1S58_16510	COG0697	spore germination
M1S58_16520	COG2814	Major facilitator Superfamily
M1S58_16525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S58_16535	COG0583	DNA-binding transcription factor activity
M1S58_16545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S58_16560	COG0084	hydrolase, TatD family'
M1S58_16575	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S58_16605	COG0440	acetolactate synthase activity
M1S58_16610	COG0028	Belongs to the TPP enzyme family
M1S58_16635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S58_16640	COG0577	efflux transmembrane transporter activity
M1S58_16640	COG1136	(ABC) transporter
M1S58_16645	COG1538	Outer membrane efflux protein
M1S58_16660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S58_16665	COG1162	GTPase activity
M1S58_16675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S58_16695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S58_16700	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_16740	COG2986	histidine ammonia-lyase
M1S58_16755	COG0318	PFAM AMP-dependent synthetase and ligase
M1S58_16765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S58_16810	COG1426	Protein conserved in bacteria
M1S58_16845	COG0793	Belongs to the peptidase S41A family
M1S58_16860	COG2267	carboxylic ester hydrolase activity
M1S58_16870	COG1012	belongs to the aldehyde dehydrogenase family
M1S58_16875	COG3265	gluconokinase activity
M1S58_16885	COG0800	Aldolase
M1S58_16895	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S58_16900	COG0857	belongs to the CobB CobQ family
M1S58_16900	COG0280	phosphate acetyltransferase
M1S58_16905	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S58_16905	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S58_16925	COG0740	serine-type endopeptidase activity
M1S58_16935	COG4774	siderophore transport
M1S58_16945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S58_16955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S58_16955	COG2813	Specifically methylates the guanine in position
M1S58_17055	COG0788	formyltetrahydrofolate deformylase activity
M1S58_17080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S58_17080	COG4651	solute:proton antiporter activity
M1S58_17100	COG0724	RNA recognition motif
M1S58_17105	COG0210	DNA helicase
M1S58_17130	COG1733	regulation of RNA biosynthetic process
M1S58_17140	COG2900	Belongs to the SlyX family
M1S58_17145	COG0488	(ABC) transporter
M1S58_17150	COG1280	lysine exporter protein (LysE YggA)
M1S58_17155	COG1560	Kdo2-lipid A biosynthetic process
M1S58_17165	COG1301	dicarboxylic acid transport
M1S58_17220	COG0473	3-isopropylmalate dehydrogenase activity
M1S58_17285	COG0583	DNA-binding transcription factor activity
M1S58_17295	COG0625	glutathione transferase activity
M1S58_17300	COG2378	regulation of single-species biofilm formation
M1S58_17305	COG0546	phosphoglycolate phosphatase activity
M1S58_17315	COG1530	ribonuclease E activity
M1S58_17320	COG0318	PFAM AMP-dependent synthetase and ligase
M1S58_17335	COG0583	DNA-binding transcription factor activity
M1S58_17340	COG4221	oxidoreductase activity
M1S58_17345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S58_17355	COG0534	Mate efflux family protein
M1S58_17370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S58_17410	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S58_17415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S58_17430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S58_17440	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S58_17440	COG0644	oxidoreductase
M1S58_17445	COG0425	Belongs to the sulfur carrier protein TusA family
M1S58_17450	COG4535	Mg2 and Co2 transporter CorC
M1S58_17460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S58_17480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S58_17485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S58_17485	COG0475	glutathione-regulated potassium exporter activity
M1S58_17490	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S58_17515	COG0789	Transcriptional regulator
M1S58_17520	COG0598	Magnesium transport protein CorA
M1S58_17535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S58_17540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S58_17545	COG1074	ATP-dependent DNA helicase activity
M1S58_17550	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S58_17570	COG2226	methyltransferase
M1S58_17585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S58_17590	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S58_17605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S58_17605	COG2111	Na H antiporter
M1S58_17610	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S58_17615	COG0651	ATP synthesis coupled electron transport
M1S58_17620	COG1863	multisubunit Na H antiporter MnhE subunit
M1S58_17625	COG2212	antiporter activity
M1S58_17630	COG1320	monovalent cation:proton antiporter activity
M1S58_17645	COG0195	Participates in both transcription termination and antitermination
M1S58_17695	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S58_17700	COG0237	dephospho-CoA kinase activity
M1S58_17710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S58_17725	COG0497	DNA recombination
M1S58_17735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S58_17765	COG2169	Transcriptional regulator
M1S58_17765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S58_17770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S58_17835	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S58_17850	COG0326	Molecular chaperone. Has ATPase activity
M1S58_17865	COG2056	Na+-H+ antiporter family
M1S58_17870	COG0596	Alpha beta hydrolase
M1S58_17965	COG0546	phosphoglycolate phosphatase activity
M1S58_17970	COG1716	ATPase activity
M1S58_18015	COG0181	hydroxymethylbilane synthase activity
M1S58_18025	COG3275	phosphorelay sensor kinase activity
M1S58_18045	COG1538	Outer membrane efflux protein
M1S58_18050	COG0697	spore germination
M1S58_18075	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S58_18080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S58_18085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S58_18090	COG0772	Belongs to the SEDS family
M1S58_18115	COG4974	Belongs to the 'phage' integrase family
M1S58_18120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S58_18130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S58_18140	COG2197	response regulator
M1S58_18155	COG0793	Belongs to the peptidase S41A family
M1S58_18160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S58_18165	COG0795	lipopolysaccharide-transporting ATPase activity
M1S58_18205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S58_18205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S58_18215	COG0004	ammonium transporteR
M1S58_18220	COG0347	Belongs to the P(II) protein family
M1S58_18285	COG0659	secondary active sulfate transmembrane transporter activity
M1S58_18330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S58_18375	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S58_18405	COG0659	secondary active sulfate transmembrane transporter activity
M1S58_18410	COG0589	response to stress
M1S58_18450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S58_18495	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S58_18525	COG0659	secondary active sulfate transmembrane transporter activity
M1S58_18530	COG0589	response to stress
M1S58_18565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S58_18575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S58_18595	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S58_18610	COG0318	PFAM AMP-dependent synthetase and ligase
M1S58_18620	COG0477	Major facilitator Superfamily
M1S58_18625	COG2860	membrane
M1S58_18635	COG1253	flavin adenine dinucleotide binding
M1S58_18655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S58_18695	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S58_18705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S58_18775	COG0758	DNA mediated transformation
M1S58_18785	COG0697	spore germination
M1S58_18790	COG1309	transcriptional regulator
M1S58_18805	COG0386	Belongs to the glutathione peroxidase family
M1S58_18870	COG1121	(ABC) transporter
M1S58_18875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S58_18880	COG1280	lysine exporter protein (LysE YggA)
M1S58_18885	COG2837	iron assimilation
M1S58_18895	COG0281	malic enzyme
M1S58_18940	COG0519	Catalyzes the synthesis of GMP from XMP
M1S58_18940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S58_18945	COG4399	Belongs to the UPF0754 family
M1S58_18950	COG2259	Doxx family
M1S58_18955	COG0586	Pfam SNARE associated Golgi protein
M1S58_18970	COG1192	Involved in chromosome partitioning
M1S58_18980	COG0271	Belongs to the BolA IbaG family
M1S58_19000	COG2267	carboxylic ester hydrolase activity
M1S58_19020	COG3321	synthase
M1S58_19020	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S58_19020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S58_19020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S58_19025	COG1960	acyl-CoA dehydrogenase activity
M1S58_19035	COG2197	response regulator
M1S58_19045	COG3916	Acyl-homoserine-lactone synthase
M1S58_19050	COG0477	Major facilitator Superfamily
M1S58_19055	COG1024	Enoyl-CoA hydratase
M1S58_19060	COG1024	Enoyl-CoA hydratase
M1S58_19065	COG1960	acyl-CoA dehydrogenase activity
M1S58_19070	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S58_19090	COG1113	amino acid transport
M1S58_19095	COG1113	amino acid transport
M1S58_19100	COG0251	oxidation-reduction process
M1S58_19140	COG0564	pseudouridine synthase activity
M1S58_19200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S58_19215	COG1802	Transcriptional regulator
M1S58_19225	COG1448	Aminotransferase
M1S58_19230	COG0277	FAD linked oxidase domain protein
M1S58_19240	COG2186	Transcriptional regulator
M1S58_19250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S58_19255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S58_19270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S58_19275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S58_19280	COG1216	Glycosyl transferase, family 2
M1S58_19310	COG2089	acid synthase
M1S58_19325	COG1083	cytidylyl-transferase
M1S58_19330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S58_19335	COG1086	Polysaccharide biosynthesis protein
M1S58_19340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S58_19345	COG1596	polysaccharide export
M1S58_19370	COG0728	peptidoglycan biosynthetic process
M1S58_19375	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S58_19435	COG0546	phosphoglycolate phosphatase activity
M1S58_19440	COG1028	Short-chain dehydrogenase reductase Sdr
M1S58_19460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S58_19465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S58_19470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S58_19475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S58_19480	COG1116	anion transmembrane transporter activity
M1S58_19485	COG1309	transcriptional regulator
M1S58_19490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S58_19500	COG0196	riboflavin kinase activity
M1S58_19505	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S58_19515	COG1047	Peptidyl-prolyl cis-trans
M1S58_19555	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S58_19560	COG0657	acetylesterase activity
M1S58_19580	COG0583	DNA-binding transcription factor activity
M1S58_19610	COG2951	lytic endotransglycosylase activity
M1S58_19615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S58_19630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S58_19640	COG0671	phosphoesterase, PA-phosphatase related
M1S58_19645	COG0861	Integral membrane protein TerC family
M1S58_19655	COG0754	glutathionylspermidine amidase activity
M1S58_19665	COG0402	S-adenosylhomocysteine deaminase activity
M1S58_19680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S58_19685	COG1230	cation diffusion facilitator family transporter
M1S58_19700	COG0706	membrane insertase activity
M1S58_19740	COG0358	DNA primase activity
M1S58_19795	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S58_19840	COG0587	DNA-directed DNA polymerase activity
M1S58_19855	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S58_19855	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S58_19905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S58_19905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S58_19910	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S58_19950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S58_19995	COG1309	transcriptional regulator
M1S58_20005	COG1902	pentaerythritol trinitrate reductase activity
M1S58_20015	COG1979	alcohol dehydrogenase
M1S58_20030	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S58_20055	COG1063	alcohol dehydrogenase
M1S58_20135	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S58_20155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system