locus-tag	class	description
M1S45_00010	COG0592	DNA-directed DNA polymerase activity
M1S45_00020	COG0187	DNA topoisomerase II activity
M1S45_00030	COG0586	Pfam SNARE associated Golgi protein
M1S45_00035	COG0488	(ABC) transporter
M1S45_00060	COG0596	Alpha beta hydrolase
M1S45_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S45_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S45_00110	COG0733	neurotransmitter:sodium symporter activity
M1S45_00150	COG2233	PERMEase
M1S45_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S45_00200	COG2814	Major facilitator Superfamily
M1S45_00205	COG0656	L-ascorbic acid biosynthetic process
M1S45_00210	COG0583	DNA-binding transcription factor activity
M1S45_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S45_00230	COG1064	alcohol dehydrogenase
M1S45_00235	COG2818	Glycosylase
M1S45_00250	COG1194	a g-specific adenine glycosylase
M1S45_00270	COG2983	Belongs to the UPF0260 family
M1S45_00275	COG2133	pyrroloquinoline quinone binding
M1S45_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S45_00285	COG2116	formate transmembrane transporter activity
M1S45_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S45_00310	COG1335	isochorismatase
M1S45_00315	COG0385	Bile acid
M1S45_00320	COG0534	Mate efflux family protein
M1S45_00325	COG1683	Conserved Protein
M1S45_00345	COG0625	glutathione transferase activity
M1S45_00355	COG1113	amino acid transport
M1S45_00365	COG0523	cobalamin synthesis protein
M1S45_00375	COG2188	Transcriptional regulator
M1S45_00405	COG0010	Belongs to the arginase family
M1S45_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S45_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S45_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S45_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S45_00540	COG0534	Mate efflux family protein
M1S45_00545	COG0436	Aminotransferase
M1S45_00550	COG2733	membrane
M1S45_00565	COG2918	glutathione biosynthetic process
M1S45_00580	COG0791	NLP P60 protein
M1S45_00580	COG1388	LysM domain
M1S45_00595	COG3150	esterase
M1S45_00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S45_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S45_00630	COG2233	PERMEase
M1S45_00635	COG2351	hydroxyisourate hydrolase activity
M1S45_00670	COG3706	GGDEF domain
M1S45_00685	COG1393	Belongs to the ArsC family
M1S45_00690	COG0708	Exodeoxyribonuclease III
M1S45_00710	COG0189	ligase activity
M1S45_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S45_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S45_00755	COG4942	peptidase
M1S45_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S45_00775	COG2119	membrane
M1S45_00780	COG4774	siderophore transport
M1S45_00785	COG0426	domain, Protein
M1S45_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S45_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S45_00830	COG1902	pentaerythritol trinitrate reductase activity
M1S45_00835	COG1519	Transferase
M1S45_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S45_00845	COG0668	transmembrane transport
M1S45_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S45_00860	COG1335	isochorismatase
M1S45_00865	COG1522	sequence-specific DNA binding
M1S45_00870	COG3328	transposase activity
M1S45_00895	COG2205	protein histidine kinase activity
M1S45_00895	COG2198	Histidine kinase
M1S45_00895	COG0784	Response regulator, receiver
M1S45_00900	COG3162	membrane
M1S45_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S45_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S45_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S45_00940	COG1309	transcriptional regulator
M1S45_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S45_00960	COG0352	thiamine-phosphate diphosphorylase activity
M1S45_00960	COG0351	phosphomethylpyrimidine kinase
M1S45_00970	COG2814	Major facilitator Superfamily
M1S45_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S45_00995	COG1113	amino acid transport
M1S45_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S45_01010	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_01020	COG1335	isochorismatase
M1S45_01050	COG2814	Major facilitator Superfamily
M1S45_01055	COG0583	DNA-binding transcription factor activity
M1S45_01075	COG0667	Aldo Keto reductase
M1S45_01110	COG1733	regulation of RNA biosynthetic process
M1S45_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S45_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S45_01195	COG2329	Antibiotic biosynthesis monooxygenase
M1S45_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S45_01255	COG0427	acetyl-CoA hydrolase
M1S45_01280	COG0659	secondary active sulfate transmembrane transporter activity
M1S45_01285	COG4221	oxidoreductase activity
M1S45_01290	COG2873	o-acetylhomoserine
M1S45_01295	COG0488	(ABC) transporter
M1S45_01380	COG0833	amino acid
M1S45_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S45_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S45_01445	COG2226	methyltransferase
M1S45_01495	COG0070	glutamate synthase
M1S45_01495	COG0069	glutamate synthase activity
M1S45_01495	COG0067	glutamate synthase
M1S45_01500	COG0493	'glutamate synthase
M1S45_01510	COG1704	LemA family
M1S45_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S45_01535	COG3307	-O-antigen
M1S45_01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S45_01570	COG0194	GDP metabolic process
M1S45_01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S45_01640	COG5380	lipid catabolic process
M1S45_01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S45_01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S45_01675	COG0277	FAD linked oxidase domain protein
M1S45_01685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S45_01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S45_01705	COG1289	transmembrane transporter activity
M1S45_01715	COG0628	permease
M1S45_01720	COG1192	Involved in chromosome partitioning
M1S45_01750	COG0833	amino acid
M1S45_01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S45_01770	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_01810	COG0583	DNA-binding transcription factor activity
M1S45_01855	COG0517	IMP dehydrogenase activity
M1S45_01860	COG1983	PspC domain protein
M1S45_01870	COG1960	acyl-CoA dehydrogenase activity
M1S45_01885	COG0408	coproporphyrinogen oxidase activity
M1S45_01905	COG0513	Belongs to the DEAD box helicase family
M1S45_01915	COG1127	ABC transporter
M1S45_01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S45_01930	COG2854	intermembrane phospholipid transfer
M1S45_01940	COG0598	Magnesium transport protein CorA
M1S45_01950	COG0494	nUDIX hydrolase
M1S45_01955	COG1040	competence protein
M1S45_01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S45_01980	COG1946	Acyl-CoA thioesterase
M1S45_01985	COG1301	dicarboxylic acid transport
M1S45_02000	COG1959	2 iron, 2 sulfur cluster binding
M1S45_02005	COG1017	nitric oxide dioxygenase activity
M1S45_02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S45_02010	COG0433	COG0433 Predicted ATPase
M1S45_02015	COG0626	cystathionine gamma-synthase activity
M1S45_02170	COG1960	acyl-CoA dehydrogenase activity
M1S45_02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S45_02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S45_02210	COG0339	signal peptide processing
M1S45_02215	COG0557	exoribonuclease II activity
M1S45_02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S45_02265	COG2169	Transcriptional regulator
M1S45_02270	COG0697	spore germination
M1S45_02275	COG1295	ribonuclease BN
M1S45_02310	COG1702	phosphate starvation-inducible protein PhoH
M1S45_02320	COG0741	lytic transglycosylase activity
M1S45_02320	COG0739	heme binding
M1S45_02320	COG1196	nuclear chromosome segregation
M1S45_02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S45_02355	COG1183	phosphatidylcholine synthase activity
M1S45_02400	COG1960	acyl-CoA dehydrogenase activity
M1S45_02405	COG1309	transcriptional regulator
M1S45_02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S45_02425	COG1960	acyl-CoA dehydrogenase activity
M1S45_02445	COG2969	positive regulation of protein catabolic process
M1S45_02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S45_02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S45_02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S45_02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S45_02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S45_02510	COG1408	metallophosphoesterase
M1S45_02520	COG2199	diguanylate cyclase activity
M1S45_02580	COG1607	acyl-coa hydrolase
M1S45_02610	COG2350	Protein conserved in bacteria
M1S45_02620	COG0613	PHP domain protein
M1S45_02625	COG3781	membrane
M1S45_02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S45_02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S45_02650	COG1862	Preprotein translocase
M1S45_02700	COG2205	protein histidine kinase activity
M1S45_02705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S45_02725	COG0726	polysaccharide deacetylase
M1S45_02730	COG0463	Glycosyl transferase, family 2
M1S45_02735	COG0438	transferase activity, transferring glycosyl groups
M1S45_02800	COG0625	glutathione transferase activity
M1S45_02805	COG0583	DNA-binding transcription factor activity
M1S45_02810	COG1960	acyl-CoA dehydrogenase activity
M1S45_02815	COG1960	acyl-CoA dehydrogenase activity
M1S45_02825	COG2205	protein histidine kinase activity
M1S45_02830	COG0745	RESPONSE REGULATOR receiver
M1S45_02835	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S45_02855	COG2096	Adenosyltransferase
M1S45_02905	COG0285	dihydrofolate synthase activity
M1S45_02925	COG0450	alkyl hydroperoxide reductase
M1S45_02940	COG0477	Major facilitator Superfamily
M1S45_02945	COG1272	protein, Hemolysin III
M1S45_02975	COG0183	Belongs to the thiolase family
M1S45_02980	COG2207	Transcriptional regulator
M1S45_03000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S45_03020	COG0183	Belongs to the thiolase family
M1S45_03030	COG2885	chlorophyll binding
M1S45_03030	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S45_03040	COG1690	Belongs to the RtcB family
M1S45_03045	COG0833	amino acid
M1S45_03055	COG2233	PERMEase
M1S45_03060	COG1217	gtp-binding protein TYPA
M1S45_03085	COG2094	Belongs to the DNA glycosylase MPG family
M1S45_03105	COG1902	pentaerythritol trinitrate reductase activity
M1S45_03120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S45_03125	COG0354	folic acid binding
M1S45_03135	COG3189	MarR family transcriptional regulator
M1S45_03140	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S45_03145	COG3422	double-strand break repair
M1S45_03185	COG0840	transmembrane signaling receptor activity
M1S45_03205	COG5510	response to toxic substance
M1S45_03215	COG2832	Protein of unknown function (DUF454)
M1S45_03220	COG1376	ErfK ybiS ycfS ynhG family protein
M1S45_03260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S45_03270	COG1289	transmembrane transporter activity
M1S45_03275	COG2814	Major facilitator Superfamily
M1S45_03295	COG1115	amino acid carrier protein
M1S45_03300	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S45_03305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S45_03310	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S45_03340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S45_03350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S45_03355	COG1077	Cell shape determining protein MreB Mrl
M1S45_03360	COG1792	Involved in formation and maintenance of cell shape
M1S45_03365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S45_03370	COG0424	maF-like protein
M1S45_03375	COG1530	ribonuclease E activity
M1S45_03395	COG0560	Phosphoserine phosphatase
M1S45_03405	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S45_03430	COG2207	Transcriptional regulator
M1S45_03450	COG1113	amino acid transport
M1S45_03455	COG2828	Protein conserved in bacteria
M1S45_03460	COG0142	geranyltranstransferase activity
M1S45_03465	COG2315	Protein conserved in bacteria
M1S45_03480	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S45_03505	COG0745	RESPONSE REGULATOR receiver
M1S45_03510	COG0642	Histidine kinase
M1S45_03520	COG0004	ammonium transporteR
M1S45_03525	COG0583	DNA-binding transcription factor activity
M1S45_03545	COG0525	valine-tRNA ligase activity
M1S45_03555	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_03565	COG0393	Putative heavy-metal-binding
M1S45_03570	COG0393	Putative heavy-metal-binding
M1S45_03575	COG1538	Outer membrane efflux protein
M1S45_03585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S45_03590	COG0671	phosphoesterase, PA-phosphatase related
M1S45_03620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S45_03635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S45_03635	COG1648	precorrin-2 dehydrogenase activity
M1S45_03640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S45_03645	COG1733	regulation of RNA biosynthetic process
M1S45_03655	COG0531	amino acid
M1S45_03670	COG0321	lipoyl(octanoyl) transferase activity
M1S45_03675	COG2921	Belongs to the UPF0250 family
M1S45_03715	COG2009	succinate dehydrogenase
M1S45_03720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S45_03725	COG1053	succinate dehydrogenase
M1S45_03730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S45_03755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S45_03775	COG2354	Protein conserved in bacteria
M1S45_03780	COG2321	neutral zinc metallopeptidase
M1S45_03800	COG2843	Capsule synthesis protein
M1S45_03815	COG0589	response to stress
M1S45_03835	COG0505	Belongs to the CarA family
M1S45_03860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S45_03865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S45_03915	COG0477	Major facilitator Superfamily
M1S45_03920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S45_03935	COG1597	lipid kinase activity
M1S45_03940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S45_03965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S45_03970	COG0584	glycerophosphoryl diester phosphodiesterase
M1S45_03990	COG0741	lytic transglycosylase activity
M1S45_04010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S45_04025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S45_04055	COG0778	Nitroreductase
M1S45_04070	COG1929	Belongs to the glycerate kinase type-1 family
M1S45_04075	COG0243	molybdopterin cofactor binding
M1S45_04080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S45_04085	COG3339	Conserved Protein
M1S45_04095	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S45_04110	COG1113	amino acid transport
M1S45_04120	COG0019	diaminopimelate decarboxylase activity
M1S45_04130	COG1280	lysine exporter protein (LysE YggA)
M1S45_04135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S45_04165	COG0463	Glycosyl transferase, family 2
M1S45_04185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S45_04220	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S45_04225	COG1136	(ABC) transporter
M1S45_04230	COG2333	competence protein COMEC
M1S45_04230	COG0658	competence protein
M1S45_04240	COG0616	signal peptide processing
M1S45_04240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S45_04245	COG0596	Alpha beta hydrolase
M1S45_04250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S45_04260	COG0628	permease
M1S45_04295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S45_04315	COG0823	Involved in the tonB-independent uptake of proteins
M1S45_04335	COG0824	Thioesterase
M1S45_04340	COG1473	amidohydrolase
M1S45_04360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S45_04360	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S45_04365	COG2814	Major facilitator Superfamily
M1S45_04375	COG1024	Enoyl-CoA hydratase
M1S45_04380	COG1051	belongs to the nudix hydrolase family
M1S45_04380	COG1056	cytidyltransferase-related domain
M1S45_04390	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S45_04405	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S45_04420	COG4625	pathogenesis
M1S45_04425	COG0583	DNA-binding transcription factor activity
M1S45_04430	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S45_04435	COG4208	sulfate ABC transporter
M1S45_04440	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S45_04450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S45_04455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S45_04460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S45_04480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S45_04495	COG0681	Belongs to the peptidase S26 family
M1S45_04510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S45_04520	COG1381	Involved in DNA repair and RecF pathway recombination
M1S45_04525	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S45_04535	COG4221	oxidoreductase activity
M1S45_04565	COG0436	Aminotransferase
M1S45_04585	COG0556	nucleotide-excision repair
M1S45_04640	COG2070	2-Nitropropane dioxygenase
M1S45_04670	COG1215	transferase activity, transferring glycosyl groups
M1S45_04685	COG0415	Belongs to the DNA photolyase family
M1S45_04695	COG1252	NADH dehydrogenase
M1S45_04700	COG1686	Belongs to the peptidase S11 family
M1S45_04715	COG1187	pseudouridine synthase activity
M1S45_04745	COG0477	Major facilitator Superfamily
M1S45_04750	COG0583	DNA-binding transcription factor activity
M1S45_04755	COG1823	symporter activity
M1S45_04765	COG0612	Peptidase, M16
M1S45_04790	COG0352	thiamine-phosphate diphosphorylase activity
M1S45_04825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S45_04840	COG1309	transcriptional regulator
M1S45_04850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S45_04855	COG0076	glutamate decarboxylase activity
M1S45_04865	COG1522	sequence-specific DNA binding
M1S45_04870	COG3961	Belongs to the TPP enzyme family
M1S45_04875	COG1113	amino acid transport
M1S45_04880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S45_04885	COG0573	inorganic phosphate transmembrane transporter activity
M1S45_04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S45_04900	COG0616	signal peptide processing
M1S45_04935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S45_04940	COG1686	Belongs to the peptidase S11 family
M1S45_04965	COG0583	DNA-binding transcription factor activity
M1S45_04970	COG1067	ATP-dependent peptidase activity
M1S45_05015	COG1966	Carbon starvation protein
M1S45_05020	COG2879	small protein
M1S45_05055	COG2508	Transcriptional regulator
M1S45_05055	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S45_05075	COG1113	amino acid transport
M1S45_05080	COG0583	DNA-binding transcription factor activity
M1S45_05090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S45_05100	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_05110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S45_05115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S45_05115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S45_05150	COG2814	Major facilitator Superfamily
M1S45_05155	COG4948	Mandelate Racemase Muconate Lactonizing
M1S45_05165	COG1309	transcriptional regulator
M1S45_05185	COG1741	Belongs to the pirin family
M1S45_05195	COG2964	Protein conserved in bacteria
M1S45_05210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S45_05215	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S45_05220	COG4605	iron ion homeostasis
M1S45_05225	COG4604	ABC transporter, ATP-binding protein
M1S45_05230	COG4607	ABC-type enterochelin transport system periplasmic component
M1S45_05235	COG4774	siderophore transport
M1S45_05245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S45_05250	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S45_05255	COG1535	isochorismatase
M1S45_05255	COG3433	isochorismatase activity
M1S45_05270	COG1132	(ABC) transporter
M1S45_05275	COG1132	(ABC) transporter
M1S45_05280	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S45_05290	COG1169	isochorismate synthase
M1S45_05305	COG3739	integral membrane protein
M1S45_05330	COG0302	gtp cyclohydrolase
M1S45_05340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S45_05370	COG0308	aminopeptidase N
M1S45_05375	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S45_05390	COG0174	glutamine synthetase
M1S45_05400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S45_05435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S45_05440	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S45_05445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S45_05465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S45_05470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S45_05475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S45_05490	COG1960	acyl-CoA dehydrogenase activity
M1S45_05495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S45_05500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S45_05510	COG2223	nitrite transmembrane transporter activity
M1S45_05520	COG0024	Methionine aminopeptidase
M1S45_05525	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S45_05540	COG2207	Transcriptional regulator
M1S45_05565	COG2951	lytic endotransglycosylase activity
M1S45_05570	COG0772	Belongs to the SEDS family
M1S45_05585	COG0842	Transport permease protein
M1S45_05590	COG1131	(ABC) transporter
M1S45_05635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S45_05650	COG4215	(ABC) transporter
M1S45_05655	COG4160	amino acid transport
M1S45_05660	COG4598	ABC transporter
M1S45_05670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S45_05675	COG0826	peptidase U32
M1S45_05680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S45_05695	COG1720	tRNA m6t6A37 methyltransferase activity
M1S45_05705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S45_05720	COG0642	Histidine kinase
M1S45_05730	COG0494	nUDIX hydrolase
M1S45_05740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S45_05745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S45_05750	COG3139	Protein of unknown function (DUF1315)
M1S45_05755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S45_05760	COG1301	dicarboxylic acid transport
M1S45_05765	COG1960	acyl-CoA dehydrogenase activity
M1S45_05770	COG2819	hydrolase of the alpha beta superfamily
M1S45_05780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S45_05790	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S45_05795	COG1234	tRNA 3'-trailer cleavage
M1S45_05825	COG2363	Small membrane protein
M1S45_05850	COG0513	Belongs to the DEAD box helicase family
M1S45_05860	COG0778	Nitroreductase
M1S45_06210	COG1286	toxin biosynthetic process
M1S45_06235	COG4783	chaperone-mediated protein folding
M1S45_06240	COG1610	YqeY-like protein
M1S45_06340	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S45_06365	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S45_06370	COG0786	glutamate:sodium symporter activity
M1S45_06380	COG2186	Transcriptional regulator
M1S45_06430	COG0477	Major facilitator Superfamily
M1S45_06460	COG2985	domain, Protein
M1S45_06470	COG2995	paraquat-inducible protein a
M1S45_06475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M1S45_06475	COG3008	intermembrane lipid transfer
M1S45_06485	COG1794	racemase activity, acting on amino acids and derivatives
M1S45_06580	COG0488	(ABC) transporter
M1S45_06585	COG3173	Aminoglycoside phosphotransferase
M1S45_06605	COG1301	dicarboxylic acid transport
M1S45_06615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S45_06620	COG2011	ABC-type metal ion transport system permease component
M1S45_06625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S45_06630	COG1464	Belongs to the NlpA lipoprotein family
M1S45_06635	COG0151	Belongs to the GarS family
M1S45_06640	COG0138	bifunctional purine biosynthesis protein purh
M1S45_06645	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S45_06675	COG2308	Evidence 4 Homologs of previously reported genes of
M1S45_06685	COG1305	Transglutaminase-like
M1S45_06695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S45_06700	COG0305	Participates in initiation and elongation during chromosome replication
M1S45_06725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S45_06740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S45_06765	COG1649	PFAM Uncharacterised BCR, COG1649
M1S45_06765	COG0726	polysaccharide deacetylase
M1S45_06770	COG1215	transferase activity, transferring glycosyl groups
M1S45_06775	COG3658	cytochrome
M1S45_06785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S45_06800	COG0583	DNA-binding transcription factor activity
M1S45_06820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S45_06825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S45_06840	COG1960	acyl-CoA dehydrogenase activity
M1S45_06845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S45_06850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S45_06875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S45_06880	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S45_06890	COG2205	protein histidine kinase activity
M1S45_06895	COG0745	RESPONSE REGULATOR receiver
M1S45_06900	COG0174	glutamine synthetase
M1S45_06920	COG0729	surface antigen
M1S45_06945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S45_06950	COG2814	Major facilitator Superfamily
M1S45_06965	COG0583	DNA-binding transcription factor activity
M1S45_06980	COG1187	pseudouridine synthase activity
M1S45_07000	COG0802	atpase or kinase
M1S45_07005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S45_07015	COG1923	regulation of RNA biosynthetic process
M1S45_07020	COG0697	spore germination
M1S45_07035	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S45_07045	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S45_07050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S45_07050	COG0519	Catalyzes the synthesis of GMP from XMP
M1S45_07055	COG4302	ethanolamine ammonia-lyase activity
M1S45_07060	COG4303	Ethanolamine ammonia lyase large subunit
M1S45_07065	COG0531	amino acid
M1S45_07085	COG1454	alcohol dehydrogenase
M1S45_07090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S45_07100	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S45_07120	COG0308	aminopeptidase N
M1S45_07130	COG4221	oxidoreductase activity
M1S45_07140	COG1605	Chorismate mutase
M1S45_07160	COG1309	transcriptional regulator
M1S45_07170	COG0668	transmembrane transport
M1S45_07205	COG4773	Receptor
M1S45_07225	COG0488	(ABC) transporter
M1S45_07230	COG0589	response to stress
M1S45_07255	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S45_07265	COG3135	benzoate transporter
M1S45_07270	COG1522	sequence-specific DNA binding
M1S45_07280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S45_07285	COG0583	DNA-binding transcription factor activity
M1S45_07295	COG0183	Belongs to the thiolase family
M1S45_07305	COG2030	dehydratase
M1S45_07310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S45_07325	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S45_07335	COG0824	Thioesterase
M1S45_07340	COG1454	alcohol dehydrogenase
M1S45_07350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S45_07370	COG0069	glutamate synthase activity
M1S45_07555	COG5410	chromosome segregation
M1S45_07760	COG2814	Major facilitator Superfamily
M1S45_07775	COG0511	ligase activity, forming carbon-carbon bonds
M1S45_07795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S45_07795	COG1116	anion transmembrane transporter activity
M1S45_07800	COG0745	RESPONSE REGULATOR receiver
M1S45_07810	COG2146	nitrite reductase [NAD(P)H] activity
M1S45_07810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S45_07815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S45_07820	COG0243	molybdopterin cofactor binding
M1S45_07830	COG0243	molybdopterin cofactor binding
M1S45_07835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S45_07850	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S45_07850	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S45_07855	COG0303	'Molybdopterin
M1S45_07865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S45_07870	COG0697	spore germination
M1S45_07890	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S45_07895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S45_07960	COG2204	response regulator
M1S45_07965	COG3852	Histidine kinase
M1S45_07985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S45_07990	COG0575	Belongs to the CDS family
M1S45_08025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S45_08040	COG2137	regulation of response to DNA damage stimulus
M1S45_08050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S45_08055	COG1011	Hydrolase
M1S45_08080	COG1522	sequence-specific DNA binding
M1S45_08110	COG0659	secondary active sulfate transmembrane transporter activity
M1S45_08115	COG2135	peptidase activity
M1S45_08130	COG5001	Diguanylate cyclase
M1S45_08130	COG3300	MHYT domain
M1S45_08150	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S45_08150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S45_08150	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S45_08155	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S45_08160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S45_08160	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S45_08190	COG0024	Methionine aminopeptidase
M1S45_08195	COG0583	DNA-binding transcription factor activity
M1S45_08205	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S45_08210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S45_08215	COG0516	GMP reductase activity
M1S45_08215	COG0517	IMP dehydrogenase activity
M1S45_08240	COG0552	protein localization to endoplasmic reticulum
M1S45_08250	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S45_08265	COG4890	Cyd operon protein YbgT
M1S45_08270	COG1294	oxidase, subunit
M1S45_08290	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S45_08300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S45_08305	COG4774	siderophore transport
M1S45_08320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S45_08325	COG0569	domain protein
M1S45_08330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S45_08360	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S45_08365	COG0542	response to heat
M1S45_08390	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S45_08390	COG1902	pentaerythritol trinitrate reductase activity
M1S45_08435	COG2323	membrane
M1S45_08440	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S45_08450	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S45_08455	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S45_08460	COG0183	Belongs to the thiolase family
M1S45_08465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S45_08470	COG0596	Alpha beta hydrolase
M1S45_08475	COG2271	Major facilitator Superfamily
M1S45_08480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S45_08485	COG3485	protocatechuate 3,4-dioxygenase
M1S45_08490	COG3485	protocatechuate 3,4-dioxygenase
M1S45_08495	COG0710	3-dehydroquinate dehydratase activity
M1S45_08500	COG3420	alginic acid biosynthetic process
M1S45_08505	COG3659	wide pore channel activity
M1S45_08510	COG4993	Dehydrogenase
M1S45_08520	COG2391	methyltransferase activity
M1S45_08535	COG1414	Transcriptional regulator
M1S45_08540	COG0583	DNA-binding transcription factor activity
M1S45_08545	COG1960	acyl-CoA dehydrogenase activity
M1S45_08570	COG2814	Major facilitator Superfamily
M1S45_08580	COG0154	amidase activity
M1S45_08600	COG4638	Rieske (2fe-2S)
M1S45_08610	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_08620	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S45_08630	COG3733	amine oxidase
M1S45_08640	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_08650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S45_08655	COG0183	Belongs to the thiolase family
M1S45_08660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S45_08665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S45_08675	COG4829	muconolactone delta-isomerase
M1S45_08680	COG4948	Mandelate Racemase Muconate Lactonizing
M1S45_08685	COG0583	DNA-binding transcription factor activity
M1S45_08695	COG2186	Transcriptional regulator
M1S45_08715	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_08735	COG1960	acyl-CoA dehydrogenase activity
M1S45_08740	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_08745	COG3829	transcription factor binding
M1S45_08755	COG3162	membrane
M1S45_08770	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_08785	COG0753	catalase activity
M1S45_08805	COG1846	Transcriptional regulator
M1S45_08810	COG1902	pentaerythritol trinitrate reductase activity
M1S45_08810	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S45_08820	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S45_08850	COG1309	transcriptional regulator
M1S45_08860	COG1335	isochorismatase
M1S45_08865	COG0583	DNA-binding transcription factor activity
M1S45_08875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S45_08875	COG0475	glutathione-regulated potassium exporter activity
M1S45_08895	COG1473	amidohydrolase
M1S45_08905	COG2831	hemolysin activation secretion protein
M1S45_08910	COG3210	domain, Protein
M1S45_08940	COG2188	Transcriptional regulator
M1S45_08955	COG0583	DNA-binding transcription factor activity
M1S45_08985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S45_09015	COG1566	PFAM secretion protein HlyD family protein
M1S45_09035	COG0129	dihydroxy-acid dehydratase activity
M1S45_09045	COG0583	DNA-binding transcription factor activity
M1S45_09050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S45_09060	COG2084	Dehydrogenase
M1S45_09065	COG2207	Transcriptional regulator
M1S45_09080	COG1064	alcohol dehydrogenase
M1S45_09090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S45_09095	COG1120	ATPase activity
M1S45_09115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S45_09235	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S45_09285	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_09300	COG2207	Transcriptional regulator
M1S45_09310	COG2205	protein histidine kinase activity
M1S45_09315	COG0745	RESPONSE REGULATOR receiver
M1S45_09320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S45_09325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S45_09330	COG1538	Outer membrane efflux protein
M1S45_09340	COG2072	flavoprotein involved in K transport
M1S45_09360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S45_09380	COG3539	Fimbrial protein
M1S45_09410	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S45_09425	COG0753	catalase activity
M1S45_09440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S45_09500	COG3433	isochorismatase activity
M1S45_09500	COG1535	isochorismatase
M1S45_09505	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_09510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S45_09515	COG4149	molybdate abc transporter
M1S45_09520	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S45_09530	COG4638	Rieske (2fe-2S)
M1S45_09535	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S45_09540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S45_09540	COG0543	2 iron, 2 sulfur cluster binding
M1S45_09565	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_09580	COG2207	Transcriptional regulator
M1S45_09590	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_09595	COG2610	gluconate transmembrane transporter activity
M1S45_09605	COG0583	DNA-binding transcription factor activity
M1S45_09615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S45_09620	COG2031	fatty acid transporter
M1S45_09625	COG0183	Belongs to the thiolase family
M1S45_09630	COG0583	DNA-binding transcription factor activity
M1S45_09635	COG0583	DNA-binding transcription factor activity
M1S45_09650	COG1027	Aspartate ammonia-lyase
M1S45_09660	COG0477	Major facilitator Superfamily
M1S45_09680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S45_09685	COG4521	taurine ABC transporter
M1S45_09700	COG2188	Transcriptional regulator
M1S45_09710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S45_09715	COG1733	regulation of RNA biosynthetic process
M1S45_09720	COG3708	Transcriptional regulator
M1S45_09720	COG2207	Transcriptional regulator
M1S45_09735	COG0730	response to heat
M1S45_09750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S45_09750	COG3453	Protein conserved in bacteria
M1S45_09760	COG3781	membrane
M1S45_09765	COG1063	alcohol dehydrogenase
M1S45_09775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S45_09780	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S45_09785	COG0022	dehydrogenase e1 component
M1S45_09790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S45_09795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S45_09825	COG0133	tryptophan synthase activity
M1S45_09835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S45_09870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S45_09895	COG2226	methyltransferase
M1S45_09950	COG0842	Transport permease protein
M1S45_09955	COG0842	Transport permease protein
M1S45_09960	COG1131	(ABC) transporter
M1S45_09975	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S45_09980	COG4773	Receptor
M1S45_10000	COG0730	response to heat
M1S45_10005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S45_10025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S45_10040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S45_10080	COG4264	IucA IucC family
M1S45_10085	COG4264	IucA IucC family
M1S45_10105	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S45_10120	COG1960	acyl-CoA dehydrogenase activity
M1S45_10125	COG1960	acyl-CoA dehydrogenase activity
M1S45_10130	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S45_10135	COG2207	Transcriptional regulator
M1S45_10140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S45_10145	COG0776	regulation of translation
M1S45_10170	COG0822	iron-sulfur transferase activity
M1S45_10175	COG0316	Belongs to the HesB IscA family
M1S45_10205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S45_10225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S45_10230	COG0702	epimerase
M1S45_10265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S45_10325	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S45_10330	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S45_10360	COG0776	regulation of translation
M1S45_10425	COG0084	hydrolase, TatD family'
M1S45_10445	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S45_10450	COG1132	(ABC) transporter
M1S45_10460	COG0811	peptide transport
M1S45_10465	COG1475	DNA binding
M1S45_10470	COG1192	Involved in chromosome partitioning
M1S45_10480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S45_10495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S45_10500	COG0191	fructose-bisphosphate aldolase activity
M1S45_10520	COG0424	maF-like protein
M1S45_10525	COG2850	peptidyl-arginine hydroxylation
M1S45_10535	COG0640	Transcriptional regulator
M1S45_10545	COG3619	membrane
M1S45_10550	COG3122	Protein conserved in bacteria
M1S45_10555	COG1132	(ABC) transporter
M1S45_10575	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S45_10580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S45_10590	COG0506	proline dehydrogenase activity
M1S45_10590	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S45_10590	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S45_10595	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S45_10610	COG3698	Phosphodiester glycosidase
M1S45_10620	COG2353	YceI-like domain
M1S45_10630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S45_10675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S45_10675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S45_10700	COG3539	Fimbrial protein
M1S45_10705	COG3121	Chaperone
M1S45_10730	COG0697	spore germination
M1S45_10740	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S45_10750	COG0583	DNA-binding transcription factor activity
M1S45_10770	COG1309	transcriptional regulator
M1S45_10785	COG1522	sequence-specific DNA binding
M1S45_10795	COG1126	abc transporter atp-binding protein
M1S45_10800	COG0765	amino acid transport
M1S45_10805	COG0765	amino acid transport
M1S45_10835	COG1464	Belongs to the NlpA lipoprotein family
M1S45_10845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S45_10850	COG2011	ABC-type metal ion transport system permease component
M1S45_10855	COG0012	GTP binding
M1S45_10880	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S45_10920	COG0386	Belongs to the glutathione peroxidase family
M1S45_10930	COG0436	Aminotransferase
M1S45_10985	COG0583	DNA-binding transcription factor activity
M1S45_10990	COG0798	PFAM Bile acid sodium symporter
M1S45_10995	COG0640	Transcriptional regulator
M1S45_11010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S45_11020	COG0583	DNA-binding transcription factor activity
M1S45_11030	COG1953	Uracil, thiamine, allantoin
M1S45_11040	COG2175	clavaminate synthase activity
M1S45_11045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S45_11050	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S45_11055	COG4521	taurine ABC transporter
M1S45_11065	COG0477	Major facilitator Superfamily
M1S45_11085	COG1271	oxidase subunit
M1S45_11090	COG1294	oxidase, subunit
M1S45_11100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S45_11120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S45_11140	COG3052	prosthetic group binding
M1S45_11145	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S45_11155	COG2814	Major facilitator Superfamily
M1S45_11175	COG1346	cytolysis
M1S45_11185	COG0583	DNA-binding transcription factor activity
M1S45_11190	COG0625	glutathione transferase activity
M1S45_11195	COG0625	glutathione transferase activity
M1S45_11200	COG0583	DNA-binding transcription factor activity
M1S45_11215	COG1045	serine acetyltransferase
M1S45_11220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S45_11225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S45_11235	COG1280	lysine exporter protein (LysE YggA)
M1S45_11250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S45_11255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S45_11260	COG1126	abc transporter atp-binding protein
M1S45_11265	COG0765	amino acid transport
M1S45_11270	COG0765	amino acid transport
M1S45_11290	COG2205	protein histidine kinase activity
M1S45_11290	COG0784	Response regulator, receiver
M1S45_11310	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S45_11330	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_11380	COG0583	DNA-binding transcription factor activity
M1S45_11400	COG0318	PFAM AMP-dependent synthetase and ligase
M1S45_11405	COG1309	transcriptional regulator
M1S45_11410	COG1960	acyl-CoA dehydrogenase activity
M1S45_11415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S45_11420	COG1024	Enoyl-CoA hydratase
M1S45_11425	COG4770	biotin carboxylase activity
M1S45_11435	COG0583	DNA-binding transcription factor activity
M1S45_11450	COG1960	acyl-CoA dehydrogenase activity
M1S45_11460	COG2814	Major facilitator Superfamily
M1S45_11470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S45_11475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S45_11480	COG2814	Major facilitator Superfamily
M1S45_11485	COG1960	acyl-CoA dehydrogenase activity
M1S45_11490	COG1024	Enoyl-CoA hydratase
M1S45_11495	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_11500	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S45_11505	COG0183	Belongs to the thiolase family
M1S45_11515	COG2814	Major facilitator Superfamily
M1S45_11525	COG1024	Enoyl-CoA hydratase
M1S45_11540	COG1960	acyl-CoA dehydrogenase activity
M1S45_11545	COG2814	Major facilitator Superfamily
M1S45_11550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S45_11555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S45_11570	COG3842	ATPase activity
M1S45_11575	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S45_11585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S45_11590	COG1414	Transcriptional regulator
M1S45_11600	COG0583	DNA-binding transcription factor activity
M1S45_11605	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S45_11610	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_11620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S45_11630	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_11635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S45_11640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S45_11645	COG2267	carboxylic ester hydrolase activity
M1S45_11665	COG3038	cytochrome b561
M1S45_11670	COG0753	catalase activity
M1S45_11705	COG2050	protein possibly involved in aromatic compounds catabolism
M1S45_11720	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S45_11725	COG0183	Belongs to the thiolase family
M1S45_11730	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S45_11735	COG1024	Enoyl-CoA hydratase
M1S45_11740	COG1024	Enoyl-CoA hydratase
M1S45_11745	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S45_11750	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S45_11755	COG3396	Phenylacetate-CoA oxygenase
M1S45_11760	COG3460	Phenylacetate-CoA oxygenase
M1S45_11765	COG3396	Phenylacetate-CoA oxygenase
M1S45_11770	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_11770	COG2030	dehydratase
M1S45_11775	COG1760	l-serine dehydratase
M1S45_11780	COG0531	amino acid
M1S45_11785	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_11800	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S45_11810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S45_11830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S45_11840	COG0789	Transcriptional regulator
M1S45_11855	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S45_11870	COG2807	transmembrane transport
M1S45_11875	COG0590	tRNA wobble adenosine to inosine editing
M1S45_11995	COG1116	anion transmembrane transporter activity
M1S45_12000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S45_12010	COG0864	Transcriptional regulator
M1S45_12030	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S45_12035	COG0439	Biotin carboxylase
M1S45_12050	COG1063	alcohol dehydrogenase
M1S45_12060	COG1309	transcriptional regulator
M1S45_12080	COG0038	chloride channel
M1S45_12085	COG4770	biotin carboxylase activity
M1S45_12105	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S45_12110	COG0583	DNA-binding transcription factor activity
M1S45_12160	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S45_12180	COG2814	Major facilitator Superfamily
M1S45_12195	COG1560	Kdo2-lipid A biosynthetic process
M1S45_12205	COG5006	permease, DMT superfamily
M1S45_12210	COG1522	sequence-specific DNA binding
M1S45_12225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S45_12235	COG4122	O-methyltransferase activity
M1S45_12265	COG1538	Outer membrane efflux protein
M1S45_12270	COG1137	ATPase activity
M1S45_12275	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S45_12285	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S45_12290	COG0517	IMP dehydrogenase activity
M1S45_12290	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S45_12325	COG2814	Major facilitator Superfamily
M1S45_12360	COG1278	Cold shock
M1S45_12365	COG1280	lysine exporter protein (LysE YggA)
M1S45_12395	COG1570	exodeoxyribonuclease VII activity
M1S45_12445	COG0583	DNA-binding transcription factor activity
M1S45_12455	COG4638	Rieske (2fe-2S)
M1S45_12460	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S45_12465	COG0543	2 iron, 2 sulfur cluster binding
M1S45_12465	COG0633	Ferredoxin
M1S45_12470	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_12475	COG3135	benzoate transporter
M1S45_12480	COG2814	Major facilitator Superfamily
M1S45_12495	COG1643	Atp-dependent helicase
M1S45_12500	COG0450	alkyl hydroperoxide reductase
M1S45_12510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S45_12540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S45_12545	COG0625	glutathione transferase activity
M1S45_12555	COG2885	chlorophyll binding
M1S45_12590	COG0542	response to heat
M1S45_12605	COG1765	OsmC-like protein
M1S45_12625	COG0667	Aldo Keto reductase
M1S45_12640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S45_12650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S45_12660	COG0527	aspartate kinase activity
M1S45_12670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S45_12680	COG3038	cytochrome b561
M1S45_12685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S45_12690	COG2252	PERMEase
M1S45_12700	COG2072	flavoprotein involved in K transport
M1S45_12755	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_12775	COG0531	amino acid
M1S45_12785	COG1113	amino acid transport
M1S45_12825	COG3209	COG3209 Rhs family protein
M1S45_12855	COG4269	membrane
M1S45_12870	COG1902	pentaerythritol trinitrate reductase activity
M1S45_12870	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S45_12880	COG3706	GGDEF domain
M1S45_12880	COG4251	negative regulation of phosphorylation
M1S45_12880	COG5001	Diguanylate cyclase
M1S45_12880	COG2203	Gaf domain
M1S45_12890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S45_12910	COG4172	Belongs to the ABC transporter superfamily
M1S45_12915	COG4239	(ABC) transporter, permease
M1S45_12920	COG4174	ABC transporter (Permease)
M1S45_12930	COG0741	lytic transglycosylase activity
M1S45_12930	COG1388	LysM domain
M1S45_12930	COG1388	LysM domain
M1S45_12930	COG0741	lytic transglycosylase activity
M1S45_12935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S45_12975	COG0583	DNA-binding transcription factor activity
M1S45_12980	COG1279	arginine transmembrane transporter activity
M1S45_13000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S45_13005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S45_13010	COG0006	proline dipeptidase activity
M1S45_13095	COG1196	nuclear chromosome segregation
M1S45_13095	COG0741	lytic transglycosylase activity
M1S45_13095	COG0739	heme binding
M1S45_13155	COG4695	Portal protein
M1S45_13255	COG0305	Participates in initiation and elongation during chromosome replication
M1S45_13270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S45_13330	COG2194	sulfuric ester hydrolase activity
M1S45_13375	COG0739	heme binding
M1S45_13705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S45_13730	COG3384	dioxygenase
M1S45_13740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S45_13745	COG2878	Part of a membrane complex involved in electron transport
M1S45_13750	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S45_13775	COG0768	penicillin binding
M1S45_13780	COG0742	ribosomal rna small subunit methyltransferase
M1S45_13795	COG0830	nickel cation binding
M1S45_13805	COG0804	urea catabolic process
M1S45_13845	COG1253	flavin adenine dinucleotide binding
M1S45_13850	COG2851	Citrate transporter
M1S45_13900	COG1773	rubredoxin
M1S45_13905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S45_13915	COG0583	DNA-binding transcription factor activity
M1S45_13940	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S45_13945	COG4181	ATPase activity
M1S45_13990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S45_14010	COG0306	phosphate transporter
M1S45_14020	COG3958	Transketolase
M1S45_14025	COG3959	Transketolase, thiamine diphosphate binding domain
M1S45_14030	COG2271	Major facilitator Superfamily
M1S45_14035	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_14040	COG0583	DNA-binding transcription factor activity
M1S45_14055	COG2223	nitrite transmembrane transporter activity
M1S45_14060	COG2207	Transcriptional regulator
M1S45_14065	COG2066	Belongs to the glutaminase family
M1S45_14070	COG0242	peptide deformylase activity
M1S45_14075	COG0477	Major facilitator Superfamily
M1S45_14085	COG0028	Belongs to the TPP enzyme family
M1S45_14100	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_14105	COG2267	carboxylic ester hydrolase activity
M1S45_14115	COG2271	Major facilitator Superfamily
M1S45_14120	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S45_14130	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_14150	COG1414	Transcriptional regulator
M1S45_14165	COG1024	Enoyl-CoA hydratase
M1S45_14175	COG1215	transferase activity, transferring glycosyl groups
M1S45_14180	COG0726	polysaccharide deacetylase
M1S45_14180	COG1649	PFAM Uncharacterised BCR, COG1649
M1S45_14190	COG4681	YaeQ
M1S45_14200	COG0523	cobalamin synthesis protein
M1S45_14210	COG1607	acyl-coa hydrolase
M1S45_14220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S45_14230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S45_14235	COG1309	transcriptional regulator
M1S45_14260	COG2040	homocysteine
M1S45_14265	COG0531	amino acid
M1S45_14290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S45_14295	COG0477	Major facilitator Superfamily
M1S45_14415	COG0592	DNA-directed DNA polymerase activity
M1S45_14455	COG2026	Addiction module toxin, RelE StbE family
M1S45_14605	COG3755	Protein conserved in bacteria
M1S45_14650	COG1484	DNA-dependent DNA replication
M1S45_14740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S45_14810	COG0405	Gamma-glutamyltransferase
M1S45_14815	COG2814	Major facilitator Superfamily
M1S45_14825	COG2050	protein possibly involved in aromatic compounds catabolism
M1S45_14840	COG1090	epimerase
M1S45_14860	COG0420	3'-5' exonuclease activity
M1S45_14885	COG0735	belongs to the Fur family
M1S45_14890	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S45_14910	COG0121	glutamine amidotransferase
M1S45_14925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S45_14935	COG0210	DNA helicase
M1S45_14940	COG2885	chlorophyll binding
M1S45_14945	COG0204	Acyl-transferase
M1S45_14960	COG2894	cell division
M1S45_14985	COG1280	lysine exporter protein (LysE YggA)
M1S45_14990	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S45_14990	COG1674	ftsk spoiiie
M1S45_14995	COG0492	ferredoxin-NADP+ reductase activity
M1S45_15000	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S45_15010	COG0456	acetyltransferase
M1S45_15055	COG1981	membrane
M1S45_15070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S45_15070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S45_15090	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_15100	COG0657	acetylesterase activity
M1S45_15110	COG0473	3-isopropylmalate dehydrogenase activity
M1S45_15115	COG0583	DNA-binding transcription factor activity
M1S45_15135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S45_15160	COG0564	pseudouridine synthase activity
M1S45_15170	COG0358	DNA primase activity
M1S45_15185	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S45_15215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S45_15245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S45_15255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S45_15255	COG0352	thiamine-phosphate diphosphorylase activity
M1S45_15255	COG0351	phosphomethylpyrimidine kinase
M1S45_15260	COG1652	LysM domain
M1S45_15285	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S45_15290	COG3101	peptidyl-lysine hydroxylation
M1S45_15295	COG0009	L-threonylcarbamoyladenylate synthase
M1S45_15300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S45_15305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S45_15320	COG4106	trans-aconitate 2-methyltransferase activity
M1S45_15335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S45_15335	COG0596	Alpha beta hydrolase
M1S45_15335	COG2226	methyltransferase
M1S45_15340	COG1877	trehalose-phosphatase activity
M1S45_15345	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S45_15350	COG2223	nitrite transmembrane transporter activity
M1S45_15370	COG1196	nuclear chromosome segregation
M1S45_15380	COG0730	response to heat
M1S45_15395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S45_15405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S45_15455	COG0489	protein tyrosine kinase activity
M1S45_15465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S45_15465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S45_15495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S45_15500	COG2081	HI0933 family
M1S45_15510	COG0668	transmembrane transport
M1S45_15530	COG0583	DNA-binding transcription factor activity
M1S45_15550	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S45_15555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S45_15585	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S45_15625	COG0745	RESPONSE REGULATOR receiver
M1S45_15645	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S45_15655	COG2205	protein histidine kinase activity
M1S45_15725	COG4993	Dehydrogenase
M1S45_15750	COG0384	phenazine biosynthesis protein PhzF
M1S45_15775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S45_15790	COG0583	DNA-binding transcription factor activity
M1S45_15820	COG0583	DNA-binding transcription factor activity
M1S45_15835	COG0583	DNA-binding transcription factor activity
M1S45_15840	COG1053	succinate dehydrogenase
M1S45_15850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S45_15855	COG2814	Major facilitator Superfamily
M1S45_15860	COG1960	acyl-CoA dehydrogenase activity
M1S45_15865	COG0583	DNA-binding transcription factor activity
M1S45_15870	COG1063	alcohol dehydrogenase
M1S45_15900	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S45_15905	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S45_15910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S45_15925	COG3667	copper resistance
M1S45_15930	COG2132	Multicopper oxidase
M1S45_15940	COG0561	phosphatase activity
M1S45_15945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S45_15970	COG1214	PFAM Peptidase M22, glycoprotease
M1S45_16020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S45_16030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S45_16035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S45_16040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S45_16100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S45_16110	COG1846	Transcriptional regulator
M1S45_16115	COG1764	response to oxidative stress
M1S45_16155	COG0037	tRNA processing
M1S45_16165	COG0248	Ppx GppA phosphatase
M1S45_16195	COG0072	phenylalanine-tRNA ligase activity
M1S45_16240	COG1238	metal cluster binding
M1S45_16245	COG0625	glutathione transferase activity
M1S45_16260	COG0318	PFAM AMP-dependent synthetase and ligase
M1S45_16265	COG3028	Belongs to the UPF0307 family
M1S45_16270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S45_16290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S45_16295	COG0617	tRNA 3'-terminal CCA addition
M1S45_16300	COG1555	photosystem II stabilization
M1S45_16305	COG3956	TIGRFAM MazG family protein
M1S45_16315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S45_16335	COG0784	Response regulator, receiver
M1S45_16335	COG5002	protein histidine kinase activity
M1S45_16335	COG2205	protein histidine kinase activity
M1S45_16340	COG1024	Enoyl-CoA hydratase
M1S45_16345	COG2084	Dehydrogenase
M1S45_16350	COG3622	Belongs to the hyi family
M1S45_16380	COG0697	spore germination
M1S45_16390	COG2814	Major facilitator Superfamily
M1S45_16395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S45_16405	COG0583	DNA-binding transcription factor activity
M1S45_16415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S45_16430	COG0084	hydrolase, TatD family'
M1S45_16445	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S45_16475	COG0440	acetolactate synthase activity
M1S45_16480	COG0028	Belongs to the TPP enzyme family
M1S45_16505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S45_16510	COG0577	efflux transmembrane transporter activity
M1S45_16510	COG1136	(ABC) transporter
M1S45_16515	COG1538	Outer membrane efflux protein
M1S45_16530	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S45_16535	COG1162	GTPase activity
M1S45_16545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S45_16565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S45_16570	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_16610	COG2986	histidine ammonia-lyase
M1S45_16625	COG0318	PFAM AMP-dependent synthetase and ligase
M1S45_16635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S45_16680	COG1426	Protein conserved in bacteria
M1S45_16715	COG0793	Belongs to the peptidase S41A family
M1S45_16730	COG2267	carboxylic ester hydrolase activity
M1S45_16740	COG1012	belongs to the aldehyde dehydrogenase family
M1S45_16745	COG3265	gluconokinase activity
M1S45_16755	COG0800	Aldolase
M1S45_16765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S45_16770	COG0857	belongs to the CobB CobQ family
M1S45_16770	COG0280	phosphate acetyltransferase
M1S45_16775	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S45_16775	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S45_16795	COG0740	serine-type endopeptidase activity
M1S45_16805	COG4774	siderophore transport
M1S45_16815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S45_16825	COG2813	Specifically methylates the guanine in position
M1S45_16825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S45_16925	COG0788	formyltetrahydrofolate deformylase activity
M1S45_16950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S45_16950	COG4651	solute:proton antiporter activity
M1S45_16970	COG0724	RNA recognition motif
M1S45_16975	COG0210	DNA helicase
M1S45_17000	COG1733	regulation of RNA biosynthetic process
M1S45_17010	COG2900	Belongs to the SlyX family
M1S45_17015	COG0488	(ABC) transporter
M1S45_17020	COG1280	lysine exporter protein (LysE YggA)
M1S45_17025	COG1560	Kdo2-lipid A biosynthetic process
M1S45_17035	COG1301	dicarboxylic acid transport
M1S45_17090	COG0473	3-isopropylmalate dehydrogenase activity
M1S45_17155	COG0583	DNA-binding transcription factor activity
M1S45_17165	COG0625	glutathione transferase activity
M1S45_17170	COG2378	regulation of single-species biofilm formation
M1S45_17175	COG0546	phosphoglycolate phosphatase activity
M1S45_17185	COG1530	ribonuclease E activity
M1S45_17190	COG0318	PFAM AMP-dependent synthetase and ligase
M1S45_17205	COG0583	DNA-binding transcription factor activity
M1S45_17210	COG4221	oxidoreductase activity
M1S45_17215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S45_17225	COG0534	Mate efflux family protein
M1S45_17240	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S45_17280	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S45_17285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S45_17300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S45_17310	COG0644	oxidoreductase
M1S45_17310	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S45_17315	COG0425	Belongs to the sulfur carrier protein TusA family
M1S45_17320	COG4535	Mg2 and Co2 transporter CorC
M1S45_17330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S45_17350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S45_17355	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S45_17355	COG0475	glutathione-regulated potassium exporter activity
M1S45_17360	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S45_17370	COG0484	heat shock protein binding
M1S45_17375	COG0789	Transcriptional regulator
M1S45_17380	COG0598	Magnesium transport protein CorA
M1S45_17395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S45_17400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S45_17405	COG1074	ATP-dependent DNA helicase activity
M1S45_17410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S45_17430	COG2226	methyltransferase
M1S45_17445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S45_17450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S45_17465	COG2111	Na H antiporter
M1S45_17465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S45_17470	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S45_17475	COG0651	ATP synthesis coupled electron transport
M1S45_17480	COG1863	multisubunit Na H antiporter MnhE subunit
M1S45_17485	COG2212	antiporter activity
M1S45_17490	COG1320	monovalent cation:proton antiporter activity
M1S45_17505	COG0195	Participates in both transcription termination and antitermination
M1S45_17555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S45_17560	COG0237	dephospho-CoA kinase activity
M1S45_17570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S45_17585	COG0497	DNA recombination
M1S45_17595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S45_17625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S45_17625	COG2169	Transcriptional regulator
M1S45_17630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S45_17695	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S45_17710	COG0326	Molecular chaperone. Has ATPase activity
M1S45_17725	COG2056	Na+-H+ antiporter family
M1S45_17730	COG0596	Alpha beta hydrolase
M1S45_17825	COG0546	phosphoglycolate phosphatase activity
M1S45_17830	COG1716	ATPase activity
M1S45_17875	COG0181	hydroxymethylbilane synthase activity
M1S45_17885	COG3275	phosphorelay sensor kinase activity
M1S45_17905	COG1538	Outer membrane efflux protein
M1S45_17910	COG0697	spore germination
M1S45_17935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S45_17940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S45_17945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S45_17950	COG0772	Belongs to the SEDS family
M1S45_17975	COG4974	Belongs to the 'phage' integrase family
M1S45_17980	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S45_17990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S45_18000	COG2197	response regulator
M1S45_18015	COG0793	Belongs to the peptidase S41A family
M1S45_18020	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S45_18025	COG0795	lipopolysaccharide-transporting ATPase activity
M1S45_18065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S45_18065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S45_18075	COG0004	ammonium transporteR
M1S45_18080	COG0347	Belongs to the P(II) protein family
M1S45_18140	COG0659	secondary active sulfate transmembrane transporter activity
M1S45_18145	COG0589	response to stress
M1S45_18185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S45_18230	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S45_18260	COG0659	secondary active sulfate transmembrane transporter activity
M1S45_18265	COG0589	response to stress
M1S45_18300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S45_18310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S45_18330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S45_18345	COG0318	PFAM AMP-dependent synthetase and ligase
M1S45_18355	COG0477	Major facilitator Superfamily
M1S45_18360	COG2860	membrane
M1S45_18370	COG1253	flavin adenine dinucleotide binding
M1S45_18390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S45_18430	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S45_18440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S45_18510	COG0758	DNA mediated transformation
M1S45_18520	COG0697	spore germination
M1S45_18525	COG1309	transcriptional regulator
M1S45_18540	COG0386	Belongs to the glutathione peroxidase family
M1S45_18605	COG1121	(ABC) transporter
M1S45_18610	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S45_18615	COG1280	lysine exporter protein (LysE YggA)
M1S45_18620	COG2837	iron assimilation
M1S45_18630	COG0281	malic enzyme
M1S45_18675	COG0519	Catalyzes the synthesis of GMP from XMP
M1S45_18675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S45_18680	COG4399	Belongs to the UPF0754 family
M1S45_18685	COG2259	Doxx family
M1S45_18690	COG0586	Pfam SNARE associated Golgi protein
M1S45_18705	COG1192	Involved in chromosome partitioning
M1S45_18715	COG0271	Belongs to the BolA IbaG family
M1S45_18735	COG2267	carboxylic ester hydrolase activity
M1S45_18755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S45_18755	COG3321	synthase
M1S45_18755	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S45_18755	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S45_18760	COG1960	acyl-CoA dehydrogenase activity
M1S45_18770	COG2197	response regulator
M1S45_18780	COG3916	Acyl-homoserine-lactone synthase
M1S45_18785	COG0477	Major facilitator Superfamily
M1S45_18790	COG1024	Enoyl-CoA hydratase
M1S45_18795	COG1024	Enoyl-CoA hydratase
M1S45_18800	COG1960	acyl-CoA dehydrogenase activity
M1S45_18805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S45_18825	COG1113	amino acid transport
M1S45_18830	COG1113	amino acid transport
M1S45_18835	COG0251	oxidation-reduction process
M1S45_18875	COG0564	pseudouridine synthase activity
M1S45_18935	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S45_18950	COG1802	Transcriptional regulator
M1S45_18960	COG1448	Aminotransferase
M1S45_18965	COG0277	FAD linked oxidase domain protein
M1S45_18975	COG2186	Transcriptional regulator
M1S45_18985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S45_18990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S45_19005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S45_19010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S45_19015	COG1216	Glycosyl transferase, family 2
M1S45_19045	COG2089	acid synthase
M1S45_19060	COG1083	cytidylyl-transferase
M1S45_19065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S45_19070	COG1086	Polysaccharide biosynthesis protein
M1S45_19075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S45_19080	COG1596	polysaccharide export
M1S45_19105	COG0728	peptidoglycan biosynthetic process
M1S45_19110	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S45_19170	COG0546	phosphoglycolate phosphatase activity
M1S45_19175	COG1028	Short-chain dehydrogenase reductase Sdr
M1S45_19195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S45_19200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S45_19205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S45_19210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S45_19215	COG1116	anion transmembrane transporter activity
M1S45_19220	COG1309	transcriptional regulator
M1S45_19225	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S45_19235	COG0196	riboflavin kinase activity
M1S45_19240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S45_19250	COG1047	Peptidyl-prolyl cis-trans
M1S45_19290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S45_19295	COG0657	acetylesterase activity
M1S45_19315	COG0583	DNA-binding transcription factor activity
M1S45_19345	COG2951	lytic endotransglycosylase activity
M1S45_19350	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S45_19365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S45_19375	COG0671	phosphoesterase, PA-phosphatase related
M1S45_19380	COG0861	Integral membrane protein TerC family
M1S45_19390	COG0754	glutathionylspermidine amidase activity
M1S45_19400	COG0402	S-adenosylhomocysteine deaminase activity
M1S45_19415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S45_19420	COG1230	cation diffusion facilitator family transporter
M1S45_19435	COG0706	membrane insertase activity
M1S45_19455	COG1192	Involved in chromosome partitioning
M1S45_19530	COG1061	Type III restriction enzyme res subunit
M1S45_19540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S45_19610	COG0484	heat shock protein binding
M1S45_19740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S45_19860	COG1525	nuclease
M1S45_19950	COG0358	DNA primase activity
M1S45_20005	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S45_20050	COG0587	DNA-directed DNA polymerase activity
M1S45_20065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S45_20065	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S45_20115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S45_20115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S45_20120	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S45_20160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S45_20205	COG1309	transcriptional regulator
M1S45_20215	COG1902	pentaerythritol trinitrate reductase activity
M1S45_20225	COG1979	alcohol dehydrogenase
M1S45_20240	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S45_20265	COG1063	alcohol dehydrogenase
M1S45_20345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S45_20365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system