locus-tag	class	description
M1S21_00010	COG0592	DNA-directed DNA polymerase activity
M1S21_00020	COG0187	DNA topoisomerase II activity
M1S21_00030	COG0586	Pfam SNARE associated Golgi protein
M1S21_00035	COG0488	(ABC) transporter
M1S21_00060	COG0596	Alpha beta hydrolase
M1S21_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S21_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S21_00110	COG0733	neurotransmitter:sodium symporter activity
M1S21_00150	COG2233	PERMEase
M1S21_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S21_00200	COG2814	Major facilitator Superfamily
M1S21_00205	COG0656	L-ascorbic acid biosynthetic process
M1S21_00210	COG0583	DNA-binding transcription factor activity
M1S21_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S21_00230	COG1064	alcohol dehydrogenase
M1S21_00235	COG2818	Glycosylase
M1S21_00250	COG1194	a g-specific adenine glycosylase
M1S21_00270	COG2983	Belongs to the UPF0260 family
M1S21_00275	COG2133	pyrroloquinoline quinone binding
M1S21_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S21_00285	COG2116	formate transmembrane transporter activity
M1S21_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S21_00310	COG1335	isochorismatase
M1S21_00315	COG0385	Bile acid
M1S21_00320	COG0534	Mate efflux family protein
M1S21_00325	COG1683	Conserved Protein
M1S21_00345	COG0625	glutathione transferase activity
M1S21_00355	COG1113	amino acid transport
M1S21_00365	COG0523	cobalamin synthesis protein
M1S21_00375	COG2188	Transcriptional regulator
M1S21_00405	COG0010	Belongs to the arginase family
M1S21_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S21_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S21_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S21_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S21_00540	COG0534	Mate efflux family protein
M1S21_00545	COG0436	Aminotransferase
M1S21_00550	COG2733	membrane
M1S21_00565	COG2918	glutathione biosynthetic process
M1S21_00580	COG1388	LysM domain
M1S21_00580	COG0791	NLP P60 protein
M1S21_00595	COG3150	esterase
M1S21_00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S21_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S21_00630	COG2233	PERMEase
M1S21_00635	COG2351	hydroxyisourate hydrolase activity
M1S21_00670	COG3706	GGDEF domain
M1S21_00685	COG1393	Belongs to the ArsC family
M1S21_00690	COG0708	Exodeoxyribonuclease III
M1S21_00710	COG0189	ligase activity
M1S21_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S21_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S21_00755	COG4942	peptidase
M1S21_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S21_00775	COG2119	membrane
M1S21_00780	COG4774	siderophore transport
M1S21_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S21_00785	COG0426	domain, Protein
M1S21_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S21_00830	COG1902	pentaerythritol trinitrate reductase activity
M1S21_00835	COG1519	Transferase
M1S21_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S21_00845	COG0668	transmembrane transport
M1S21_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S21_00860	COG1335	isochorismatase
M1S21_00865	COG1522	sequence-specific DNA binding
M1S21_00870	COG3328	transposase activity
M1S21_00895	COG0784	Response regulator, receiver
M1S21_00895	COG2198	Histidine kinase
M1S21_00895	COG2205	protein histidine kinase activity
M1S21_00900	COG3162	membrane
M1S21_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S21_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S21_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S21_00940	COG1309	transcriptional regulator
M1S21_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S21_00960	COG0352	thiamine-phosphate diphosphorylase activity
M1S21_00960	COG0351	phosphomethylpyrimidine kinase
M1S21_00970	COG2814	Major facilitator Superfamily
M1S21_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S21_00995	COG1113	amino acid transport
M1S21_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S21_01010	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_01020	COG1335	isochorismatase
M1S21_01050	COG2814	Major facilitator Superfamily
M1S21_01055	COG0583	DNA-binding transcription factor activity
M1S21_01075	COG0667	Aldo Keto reductase
M1S21_01110	COG1733	regulation of RNA biosynthetic process
M1S21_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S21_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S21_01195	COG2329	Antibiotic biosynthesis monooxygenase
M1S21_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S21_01255	COG0427	acetyl-CoA hydrolase
M1S21_01280	COG0659	secondary active sulfate transmembrane transporter activity
M1S21_01285	COG4221	oxidoreductase activity
M1S21_01290	COG2873	o-acetylhomoserine
M1S21_01295	COG0488	(ABC) transporter
M1S21_01380	COG0833	amino acid
M1S21_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S21_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S21_01445	COG2226	methyltransferase
M1S21_01495	COG0067	glutamate synthase
M1S21_01495	COG0069	glutamate synthase activity
M1S21_01495	COG0070	glutamate synthase
M1S21_01500	COG0493	'glutamate synthase
M1S21_01510	COG1704	LemA family
M1S21_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S21_01535	COG3307	-O-antigen
M1S21_01560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S21_01575	COG0194	GDP metabolic process
M1S21_01625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S21_01645	COG5380	lipid catabolic process
M1S21_01650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S21_01675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S21_01680	COG0277	FAD linked oxidase domain protein
M1S21_01690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S21_01695	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S21_01710	COG1289	transmembrane transporter activity
M1S21_01720	COG0628	permease
M1S21_01725	COG1192	Involved in chromosome partitioning
M1S21_01755	COG0833	amino acid
M1S21_01760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S21_01765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S21_01775	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_01815	COG0583	DNA-binding transcription factor activity
M1S21_01860	COG0517	IMP dehydrogenase activity
M1S21_01865	COG1983	PspC domain protein
M1S21_01875	COG1960	acyl-CoA dehydrogenase activity
M1S21_01890	COG0408	coproporphyrinogen oxidase activity
M1S21_01910	COG0513	Belongs to the DEAD box helicase family
M1S21_01920	COG1127	ABC transporter
M1S21_01925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S21_01935	COG2854	intermembrane phospholipid transfer
M1S21_01945	COG0598	Magnesium transport protein CorA
M1S21_01955	COG0494	nUDIX hydrolase
M1S21_01960	COG1040	competence protein
M1S21_01965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S21_01985	COG1946	Acyl-CoA thioesterase
M1S21_01990	COG1301	dicarboxylic acid transport
M1S21_02005	COG1959	2 iron, 2 sulfur cluster binding
M1S21_02010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S21_02010	COG1017	nitric oxide dioxygenase activity
M1S21_02015	COG0433	COG0433 Predicted ATPase
M1S21_02020	COG0626	cystathionine gamma-synthase activity
M1S21_02175	COG1960	acyl-CoA dehydrogenase activity
M1S21_02180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S21_02210	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S21_02215	COG0339	signal peptide processing
M1S21_02220	COG0557	exoribonuclease II activity
M1S21_02265	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S21_02270	COG2169	Transcriptional regulator
M1S21_02275	COG0697	spore germination
M1S21_02280	COG1295	ribonuclease BN
M1S21_02315	COG1702	phosphate starvation-inducible protein PhoH
M1S21_02325	COG0739	heme binding
M1S21_02325	COG0741	lytic transglycosylase activity
M1S21_02325	COG1196	nuclear chromosome segregation
M1S21_02355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S21_02360	COG1183	phosphatidylcholine synthase activity
M1S21_02405	COG1960	acyl-CoA dehydrogenase activity
M1S21_02410	COG1309	transcriptional regulator
M1S21_02425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S21_02430	COG1960	acyl-CoA dehydrogenase activity
M1S21_02450	COG2969	positive regulation of protein catabolic process
M1S21_02460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S21_02475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S21_02480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S21_02500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S21_02510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S21_02515	COG1408	metallophosphoesterase
M1S21_02525	COG2199	diguanylate cyclase activity
M1S21_02585	COG1607	acyl-coa hydrolase
M1S21_02615	COG2350	Protein conserved in bacteria
M1S21_02625	COG0613	PHP domain protein
M1S21_02630	COG3781	membrane
M1S21_02640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S21_02645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S21_02655	COG1862	Preprotein translocase
M1S21_02685	COG2205	protein histidine kinase activity
M1S21_02690	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S21_02710	COG0726	polysaccharide deacetylase
M1S21_02715	COG0463	Glycosyl transferase, family 2
M1S21_02720	COG0438	transferase activity, transferring glycosyl groups
M1S21_02785	COG0625	glutathione transferase activity
M1S21_02790	COG0583	DNA-binding transcription factor activity
M1S21_02795	COG1960	acyl-CoA dehydrogenase activity
M1S21_02800	COG1960	acyl-CoA dehydrogenase activity
M1S21_02810	COG2205	protein histidine kinase activity
M1S21_02815	COG0745	RESPONSE REGULATOR receiver
M1S21_02820	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S21_02840	COG2096	Adenosyltransferase
M1S21_02890	COG0285	dihydrofolate synthase activity
M1S21_02910	COG0450	alkyl hydroperoxide reductase
M1S21_02925	COG0477	Major facilitator Superfamily
M1S21_02930	COG1272	protein, Hemolysin III
M1S21_02960	COG0183	Belongs to the thiolase family
M1S21_02965	COG2207	Transcriptional regulator
M1S21_02985	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S21_03005	COG0183	Belongs to the thiolase family
M1S21_03015	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S21_03015	COG2885	chlorophyll binding
M1S21_03025	COG1690	Belongs to the RtcB family
M1S21_03030	COG0833	amino acid
M1S21_03040	COG2233	PERMEase
M1S21_03045	COG1217	gtp-binding protein TYPA
M1S21_03070	COG2094	Belongs to the DNA glycosylase MPG family
M1S21_03090	COG1902	pentaerythritol trinitrate reductase activity
M1S21_03105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S21_03110	COG0354	folic acid binding
M1S21_03120	COG3189	MarR family transcriptional regulator
M1S21_03125	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S21_03130	COG3422	double-strand break repair
M1S21_03170	COG0840	transmembrane signaling receptor activity
M1S21_03190	COG5510	response to toxic substance
M1S21_03200	COG2832	Protein of unknown function (DUF454)
M1S21_03205	COG1376	ErfK ybiS ycfS ynhG family protein
M1S21_03245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S21_03255	COG1289	transmembrane transporter activity
M1S21_03260	COG2814	Major facilitator Superfamily
M1S21_03280	COG1115	amino acid carrier protein
M1S21_03285	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S21_03290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S21_03295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S21_03325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S21_03335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S21_03340	COG1077	Cell shape determining protein MreB Mrl
M1S21_03345	COG1792	Involved in formation and maintenance of cell shape
M1S21_03350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S21_03355	COG0424	maF-like protein
M1S21_03360	COG1530	ribonuclease E activity
M1S21_03370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S21_03380	COG0560	Phosphoserine phosphatase
M1S21_03390	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S21_03415	COG2207	Transcriptional regulator
M1S21_03435	COG1113	amino acid transport
M1S21_03440	COG2828	Protein conserved in bacteria
M1S21_03445	COG0142	geranyltranstransferase activity
M1S21_03450	COG2315	Protein conserved in bacteria
M1S21_03465	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S21_03485	COG2194	sulfuric ester hydrolase activity
M1S21_03490	COG0745	RESPONSE REGULATOR receiver
M1S21_03495	COG0642	Histidine kinase
M1S21_03505	COG0004	ammonium transporteR
M1S21_03510	COG0583	DNA-binding transcription factor activity
M1S21_03530	COG0525	valine-tRNA ligase activity
M1S21_03540	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_03550	COG0393	Putative heavy-metal-binding
M1S21_03555	COG0393	Putative heavy-metal-binding
M1S21_03560	COG1538	Outer membrane efflux protein
M1S21_03570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S21_03575	COG0671	phosphoesterase, PA-phosphatase related
M1S21_03605	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S21_03620	COG1648	precorrin-2 dehydrogenase activity
M1S21_03620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S21_03625	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S21_03630	COG1733	regulation of RNA biosynthetic process
M1S21_03640	COG0531	amino acid
M1S21_03655	COG0321	lipoyl(octanoyl) transferase activity
M1S21_03660	COG2921	Belongs to the UPF0250 family
M1S21_03700	COG2009	succinate dehydrogenase
M1S21_03705	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S21_03710	COG1053	succinate dehydrogenase
M1S21_03715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S21_03740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S21_03760	COG2354	Protein conserved in bacteria
M1S21_03765	COG2321	neutral zinc metallopeptidase
M1S21_03785	COG2843	Capsule synthesis protein
M1S21_03800	COG0589	response to stress
M1S21_03820	COG0505	Belongs to the CarA family
M1S21_03845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S21_03850	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S21_03900	COG0477	Major facilitator Superfamily
M1S21_03905	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S21_03920	COG1597	lipid kinase activity
M1S21_03925	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S21_03955	COG0584	glycerophosphoryl diester phosphodiesterase
M1S21_03975	COG0741	lytic transglycosylase activity
M1S21_03995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S21_04010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S21_04040	COG0778	Nitroreductase
M1S21_04055	COG1929	Belongs to the glycerate kinase type-1 family
M1S21_04060	COG0243	molybdopterin cofactor binding
M1S21_04065	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S21_04070	COG3339	Conserved Protein
M1S21_04080	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S21_04095	COG1113	amino acid transport
M1S21_04105	COG0019	diaminopimelate decarboxylase activity
M1S21_04115	COG1280	lysine exporter protein (LysE YggA)
M1S21_04120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S21_04150	COG0463	Glycosyl transferase, family 2
M1S21_04170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S21_04205	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S21_04210	COG1136	(ABC) transporter
M1S21_04215	COG2333	competence protein COMEC
M1S21_04215	COG0658	competence protein
M1S21_04225	COG0616	signal peptide processing
M1S21_04225	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S21_04230	COG0596	Alpha beta hydrolase
M1S21_04235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S21_04245	COG0628	permease
M1S21_04280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S21_04300	COG0823	Involved in the tonB-independent uptake of proteins
M1S21_04320	COG0824	Thioesterase
M1S21_04325	COG1473	amidohydrolase
M1S21_04345	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S21_04345	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S21_04350	COG2814	Major facilitator Superfamily
M1S21_04360	COG1024	Enoyl-CoA hydratase
M1S21_04365	COG1056	cytidyltransferase-related domain
M1S21_04365	COG1051	belongs to the nudix hydrolase family
M1S21_04375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S21_04390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S21_04405	COG4625	pathogenesis
M1S21_04410	COG0583	DNA-binding transcription factor activity
M1S21_04415	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S21_04420	COG4208	sulfate ABC transporter
M1S21_04425	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S21_04435	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S21_04440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S21_04445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S21_04465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S21_04480	COG0681	Belongs to the peptidase S26 family
M1S21_04495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S21_04505	COG1381	Involved in DNA repair and RecF pathway recombination
M1S21_04510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S21_04520	COG4221	oxidoreductase activity
M1S21_04550	COG0436	Aminotransferase
M1S21_04570	COG0556	nucleotide-excision repair
M1S21_04625	COG2070	2-Nitropropane dioxygenase
M1S21_04655	COG1215	transferase activity, transferring glycosyl groups
M1S21_04670	COG0415	Belongs to the DNA photolyase family
M1S21_04680	COG1252	NADH dehydrogenase
M1S21_04685	COG1686	Belongs to the peptidase S11 family
M1S21_04700	COG1187	pseudouridine synthase activity
M1S21_04725	COG0477	Major facilitator Superfamily
M1S21_04730	COG0583	DNA-binding transcription factor activity
M1S21_04735	COG1823	symporter activity
M1S21_04745	COG0612	Peptidase, M16
M1S21_04770	COG0352	thiamine-phosphate diphosphorylase activity
M1S21_04805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S21_04820	COG1309	transcriptional regulator
M1S21_04830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S21_04835	COG0076	glutamate decarboxylase activity
M1S21_04845	COG1522	sequence-specific DNA binding
M1S21_04850	COG3961	Belongs to the TPP enzyme family
M1S21_04855	COG1113	amino acid transport
M1S21_04860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S21_04865	COG0573	inorganic phosphate transmembrane transporter activity
M1S21_04875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S21_04880	COG0616	signal peptide processing
M1S21_04915	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S21_04920	COG1686	Belongs to the peptidase S11 family
M1S21_04945	COG0583	DNA-binding transcription factor activity
M1S21_04950	COG1067	ATP-dependent peptidase activity
M1S21_04995	COG1966	Carbon starvation protein
M1S21_05000	COG2879	small protein
M1S21_05035	COG2508	Transcriptional regulator
M1S21_05035	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S21_05055	COG1113	amino acid transport
M1S21_05060	COG0583	DNA-binding transcription factor activity
M1S21_05065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S21_05070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S21_05080	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_05090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S21_05095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S21_05095	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S21_05130	COG2814	Major facilitator Superfamily
M1S21_05135	COG4948	Mandelate Racemase Muconate Lactonizing
M1S21_05145	COG1309	transcriptional regulator
M1S21_05165	COG1741	Belongs to the pirin family
M1S21_05175	COG2964	Protein conserved in bacteria
M1S21_05190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S21_05195	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S21_05200	COG4605	iron ion homeostasis
M1S21_05205	COG4604	ABC transporter, ATP-binding protein
M1S21_05210	COG4607	ABC-type enterochelin transport system periplasmic component
M1S21_05215	COG4774	siderophore transport
M1S21_05225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S21_05230	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S21_05235	COG1535	isochorismatase
M1S21_05235	COG3433	isochorismatase activity
M1S21_05250	COG1132	(ABC) transporter
M1S21_05255	COG1132	(ABC) transporter
M1S21_05260	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S21_05270	COG1169	isochorismate synthase
M1S21_05285	COG3739	integral membrane protein
M1S21_05310	COG0302	gtp cyclohydrolase
M1S21_05320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S21_05350	COG0308	aminopeptidase N
M1S21_05355	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S21_05675	COG0582	viral genome integration into host DNA
M1S21_05690	COG0174	glutamine synthetase
M1S21_05700	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S21_05735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S21_05740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S21_05745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S21_05765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S21_05770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S21_05775	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S21_05790	COG1960	acyl-CoA dehydrogenase activity
M1S21_05795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S21_05800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S21_05810	COG2223	nitrite transmembrane transporter activity
M1S21_05820	COG0024	Methionine aminopeptidase
M1S21_05825	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S21_05840	COG2207	Transcriptional regulator
M1S21_05865	COG2951	lytic endotransglycosylase activity
M1S21_05885	COG0842	Transport permease protein
M1S21_05890	COG1131	(ABC) transporter
M1S21_05935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S21_05950	COG4215	(ABC) transporter
M1S21_05955	COG4160	amino acid transport
M1S21_05960	COG4598	ABC transporter
M1S21_05970	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S21_05975	COG0826	peptidase U32
M1S21_05980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S21_05995	COG1720	tRNA m6t6A37 methyltransferase activity
M1S21_06005	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S21_06020	COG0642	Histidine kinase
M1S21_06030	COG0494	nUDIX hydrolase
M1S21_06040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S21_06045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S21_06050	COG3139	Protein of unknown function (DUF1315)
M1S21_06055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S21_06060	COG1301	dicarboxylic acid transport
M1S21_06065	COG1960	acyl-CoA dehydrogenase activity
M1S21_06070	COG2819	hydrolase of the alpha beta superfamily
M1S21_06080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S21_06090	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S21_06095	COG1234	tRNA 3'-trailer cleavage
M1S21_06125	COG2363	Small membrane protein
M1S21_06150	COG0513	Belongs to the DEAD box helicase family
M1S21_06160	COG0778	Nitroreductase
M1S21_06190	COG1286	toxin biosynthetic process
M1S21_06215	COG4783	chaperone-mediated protein folding
M1S21_06220	COG1610	YqeY-like protein
M1S21_06320	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S21_06430	COG0488	(ABC) transporter
M1S21_06435	COG3173	Aminoglycoside phosphotransferase
M1S21_06445	COG2433	Pfam Transposase IS66
M1S21_06485	COG1301	dicarboxylic acid transport
M1S21_06495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S21_06500	COG2011	ABC-type metal ion transport system permease component
M1S21_06505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S21_06510	COG1464	Belongs to the NlpA lipoprotein family
M1S21_06515	COG0151	Belongs to the GarS family
M1S21_06520	COG0138	bifunctional purine biosynthesis protein purh
M1S21_06525	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S21_06555	COG2308	Evidence 4 Homologs of previously reported genes of
M1S21_06565	COG1305	Transglutaminase-like
M1S21_06575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S21_06580	COG0305	Participates in initiation and elongation during chromosome replication
M1S21_06605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S21_06615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S21_06620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S21_06645	COG1649	PFAM Uncharacterised BCR, COG1649
M1S21_06645	COG0726	polysaccharide deacetylase
M1S21_06650	COG1215	transferase activity, transferring glycosyl groups
M1S21_06655	COG3658	cytochrome
M1S21_06665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S21_06680	COG0583	DNA-binding transcription factor activity
M1S21_06700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S21_06705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S21_06720	COG1960	acyl-CoA dehydrogenase activity
M1S21_06725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S21_06730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S21_06755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S21_06760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S21_06770	COG2205	protein histidine kinase activity
M1S21_06775	COG0745	RESPONSE REGULATOR receiver
M1S21_06780	COG0174	glutamine synthetase
M1S21_06800	COG0729	surface antigen
M1S21_06825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S21_06830	COG2814	Major facilitator Superfamily
M1S21_06845	COG0583	DNA-binding transcription factor activity
M1S21_06860	COG1187	pseudouridine synthase activity
M1S21_06880	COG0802	atpase or kinase
M1S21_06885	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S21_06895	COG1923	regulation of RNA biosynthetic process
M1S21_06900	COG0697	spore germination
M1S21_06915	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S21_06925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S21_06930	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S21_06930	COG0519	Catalyzes the synthesis of GMP from XMP
M1S21_06935	COG4302	ethanolamine ammonia-lyase activity
M1S21_06940	COG4303	Ethanolamine ammonia lyase large subunit
M1S21_06945	COG0531	amino acid
M1S21_06965	COG1454	alcohol dehydrogenase
M1S21_06970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S21_06980	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S21_07000	COG0308	aminopeptidase N
M1S21_07010	COG4221	oxidoreductase activity
M1S21_07020	COG1605	Chorismate mutase
M1S21_07040	COG1309	transcriptional regulator
M1S21_07050	COG0668	transmembrane transport
M1S21_07085	COG4773	Receptor
M1S21_07105	COG0488	(ABC) transporter
M1S21_07110	COG0589	response to stress
M1S21_07135	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S21_07145	COG3135	benzoate transporter
M1S21_07150	COG1522	sequence-specific DNA binding
M1S21_07160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S21_07165	COG0583	DNA-binding transcription factor activity
M1S21_07175	COG0183	Belongs to the thiolase family
M1S21_07185	COG2030	dehydratase
M1S21_07190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S21_07205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S21_07215	COG0824	Thioesterase
M1S21_07220	COG1454	alcohol dehydrogenase
M1S21_07230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S21_07250	COG0069	glutamate synthase activity
M1S21_07425	COG5410	chromosome segregation
M1S21_07570	COG1196	nuclear chromosome segregation
M1S21_07570	COG0741	lytic transglycosylase activity
M1S21_07570	COG0739	heme binding
M1S21_07640	COG2814	Major facilitator Superfamily
M1S21_07655	COG0511	ligase activity, forming carbon-carbon bonds
M1S21_07675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S21_07675	COG1116	anion transmembrane transporter activity
M1S21_07680	COG0745	RESPONSE REGULATOR receiver
M1S21_07690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S21_07690	COG2146	nitrite reductase [NAD(P)H] activity
M1S21_07695	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S21_07700	COG0243	molybdopterin cofactor binding
M1S21_07710	COG0243	molybdopterin cofactor binding
M1S21_07715	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S21_07730	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S21_07730	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S21_07735	COG0303	'Molybdopterin
M1S21_07745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S21_07750	COG0697	spore germination
M1S21_07770	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S21_07775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S21_07840	COG2204	response regulator
M1S21_07845	COG3852	Histidine kinase
M1S21_07865	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S21_07870	COG0575	Belongs to the CDS family
M1S21_07905	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S21_07920	COG2137	regulation of response to DNA damage stimulus
M1S21_07930	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S21_07935	COG1011	Hydrolase
M1S21_07960	COG1522	sequence-specific DNA binding
M1S21_07970	COG1113	amino acid transport
M1S21_07990	COG0659	secondary active sulfate transmembrane transporter activity
M1S21_07995	COG2135	peptidase activity
M1S21_08010	COG3300	MHYT domain
M1S21_08010	COG5001	Diguanylate cyclase
M1S21_08030	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S21_08030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S21_08030	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S21_08035	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S21_08040	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S21_08040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S21_08070	COG0024	Methionine aminopeptidase
M1S21_08075	COG0583	DNA-binding transcription factor activity
M1S21_08085	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S21_08090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S21_08095	COG0516	GMP reductase activity
M1S21_08095	COG0517	IMP dehydrogenase activity
M1S21_08120	COG0552	protein localization to endoplasmic reticulum
M1S21_08130	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S21_08145	COG4890	Cyd operon protein YbgT
M1S21_08150	COG1294	oxidase, subunit
M1S21_08165	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S21_08175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S21_08180	COG4774	siderophore transport
M1S21_08195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S21_08200	COG0569	domain protein
M1S21_08205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S21_08235	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S21_08240	COG0542	response to heat
M1S21_08265	COG1902	pentaerythritol trinitrate reductase activity
M1S21_08265	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S21_08310	COG2323	membrane
M1S21_08315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S21_08325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S21_08330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S21_08335	COG0183	Belongs to the thiolase family
M1S21_08340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S21_08345	COG0596	Alpha beta hydrolase
M1S21_08350	COG2271	Major facilitator Superfamily
M1S21_08355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S21_08360	COG3485	protocatechuate 3,4-dioxygenase
M1S21_08365	COG3485	protocatechuate 3,4-dioxygenase
M1S21_08370	COG0710	3-dehydroquinate dehydratase activity
M1S21_08375	COG3420	alginic acid biosynthetic process
M1S21_08380	COG3659	wide pore channel activity
M1S21_08385	COG4993	Dehydrogenase
M1S21_08395	COG2391	methyltransferase activity
M1S21_08410	COG1414	Transcriptional regulator
M1S21_08415	COG0583	DNA-binding transcription factor activity
M1S21_08420	COG1960	acyl-CoA dehydrogenase activity
M1S21_08445	COG2814	Major facilitator Superfamily
M1S21_08455	COG0154	amidase activity
M1S21_08475	COG4638	Rieske (2fe-2S)
M1S21_08485	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_08495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S21_08505	COG3733	amine oxidase
M1S21_08515	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_08525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S21_08530	COG0183	Belongs to the thiolase family
M1S21_08535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S21_08540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S21_08550	COG4829	muconolactone delta-isomerase
M1S21_08555	COG4948	Mandelate Racemase Muconate Lactonizing
M1S21_08560	COG0583	DNA-binding transcription factor activity
M1S21_08570	COG2186	Transcriptional regulator
M1S21_08590	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_08610	COG1960	acyl-CoA dehydrogenase activity
M1S21_08615	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_08620	COG3829	transcription factor binding
M1S21_08630	COG3162	membrane
M1S21_08645	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_08660	COG0753	catalase activity
M1S21_08680	COG1846	Transcriptional regulator
M1S21_08685	COG1902	pentaerythritol trinitrate reductase activity
M1S21_08685	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S21_08695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S21_08725	COG1309	transcriptional regulator
M1S21_08735	COG1335	isochorismatase
M1S21_08740	COG0583	DNA-binding transcription factor activity
M1S21_08750	COG0475	glutathione-regulated potassium exporter activity
M1S21_08750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S21_08760	COG1473	amidohydrolase
M1S21_08770	COG2831	hemolysin activation secretion protein
M1S21_08775	COG3210	domain, Protein
M1S21_08805	COG2188	Transcriptional regulator
M1S21_08820	COG0583	DNA-binding transcription factor activity
M1S21_08850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S21_08880	COG1566	PFAM secretion protein HlyD family protein
M1S21_08895	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_08900	COG0129	dihydroxy-acid dehydratase activity
M1S21_08910	COG0583	DNA-binding transcription factor activity
M1S21_08915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S21_08925	COG2084	Dehydrogenase
M1S21_08930	COG2207	Transcriptional regulator
M1S21_08945	COG1064	alcohol dehydrogenase
M1S21_08955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S21_08960	COG1120	ATPase activity
M1S21_08980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S21_09100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S21_09150	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_09165	COG2207	Transcriptional regulator
M1S21_09175	COG2205	protein histidine kinase activity
M1S21_09180	COG0745	RESPONSE REGULATOR receiver
M1S21_09185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S21_09190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S21_09195	COG1538	Outer membrane efflux protein
M1S21_09205	COG2072	flavoprotein involved in K transport
M1S21_09225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S21_09245	COG3539	Fimbrial protein
M1S21_09275	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S21_09285	COG0753	catalase activity
M1S21_09300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S21_09360	COG1535	isochorismatase
M1S21_09360	COG3433	isochorismatase activity
M1S21_09365	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_09370	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S21_09375	COG4149	molybdate abc transporter
M1S21_09380	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S21_09390	COG4638	Rieske (2fe-2S)
M1S21_09395	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S21_09400	COG0543	2 iron, 2 sulfur cluster binding
M1S21_09400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S21_09425	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_09440	COG2207	Transcriptional regulator
M1S21_09450	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_09455	COG2610	gluconate transmembrane transporter activity
M1S21_09465	COG0583	DNA-binding transcription factor activity
M1S21_09475	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S21_09480	COG2031	fatty acid transporter
M1S21_09485	COG0183	Belongs to the thiolase family
M1S21_09490	COG0583	DNA-binding transcription factor activity
M1S21_09495	COG0583	DNA-binding transcription factor activity
M1S21_09510	COG1027	Aspartate ammonia-lyase
M1S21_09520	COG0477	Major facilitator Superfamily
M1S21_09540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S21_09545	COG4521	taurine ABC transporter
M1S21_09560	COG2188	Transcriptional regulator
M1S21_09570	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S21_09575	COG1733	regulation of RNA biosynthetic process
M1S21_09580	COG2207	Transcriptional regulator
M1S21_09580	COG3708	Transcriptional regulator
M1S21_09595	COG0730	response to heat
M1S21_09610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S21_09610	COG3453	Protein conserved in bacteria
M1S21_09620	COG3781	membrane
M1S21_09625	COG1063	alcohol dehydrogenase
M1S21_09635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S21_09640	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S21_09645	COG0022	dehydrogenase e1 component
M1S21_09650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S21_09655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S21_09670	COG3706	GGDEF domain
M1S21_09685	COG0133	tryptophan synthase activity
M1S21_09695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S21_09730	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S21_09755	COG2226	methyltransferase
M1S21_09810	COG0842	Transport permease protein
M1S21_09815	COG0842	Transport permease protein
M1S21_09820	COG1131	(ABC) transporter
M1S21_09835	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S21_09840	COG4773	Receptor
M1S21_09860	COG0730	response to heat
M1S21_09865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S21_09885	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S21_09900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S21_09940	COG4264	IucA IucC family
M1S21_09945	COG4264	IucA IucC family
M1S21_09965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S21_09980	COG1960	acyl-CoA dehydrogenase activity
M1S21_09985	COG1960	acyl-CoA dehydrogenase activity
M1S21_09990	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S21_09995	COG2207	Transcriptional regulator
M1S21_10000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S21_10005	COG0776	regulation of translation
M1S21_10030	COG0822	iron-sulfur transferase activity
M1S21_10035	COG0316	Belongs to the HesB IscA family
M1S21_10065	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S21_10085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S21_10090	COG0702	epimerase
M1S21_10125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S21_10135	COG0339	signal peptide processing
M1S21_10185	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S21_10190	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S21_10220	COG0776	regulation of translation
M1S21_10285	COG0084	hydrolase, TatD family'
M1S21_10305	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S21_10310	COG1132	(ABC) transporter
M1S21_10320	COG0811	peptide transport
M1S21_10325	COG1475	DNA binding
M1S21_10330	COG1192	Involved in chromosome partitioning
M1S21_10340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S21_10355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S21_10360	COG0191	fructose-bisphosphate aldolase activity
M1S21_10380	COG0424	maF-like protein
M1S21_10385	COG2850	peptidyl-arginine hydroxylation
M1S21_10395	COG0640	Transcriptional regulator
M1S21_10405	COG3619	membrane
M1S21_10410	COG3122	Protein conserved in bacteria
M1S21_10415	COG1132	(ABC) transporter
M1S21_10435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S21_10440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S21_10450	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S21_10450	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S21_10450	COG0506	proline dehydrogenase activity
M1S21_10455	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S21_10470	COG3698	Phosphodiester glycosidase
M1S21_10480	COG2353	YceI-like domain
M1S21_10490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S21_10535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S21_10535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S21_10560	COG3539	Fimbrial protein
M1S21_10565	COG3121	Chaperone
M1S21_10590	COG0697	spore germination
M1S21_10600	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S21_10610	COG0583	DNA-binding transcription factor activity
M1S21_10630	COG1309	transcriptional regulator
M1S21_10645	COG1522	sequence-specific DNA binding
M1S21_10660	COG1126	abc transporter atp-binding protein
M1S21_10665	COG0765	amino acid transport
M1S21_10670	COG0765	amino acid transport
M1S21_10700	COG1464	Belongs to the NlpA lipoprotein family
M1S21_10710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S21_10715	COG2011	ABC-type metal ion transport system permease component
M1S21_10720	COG0012	GTP binding
M1S21_10745	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S21_10785	COG0386	Belongs to the glutathione peroxidase family
M1S21_10795	COG0436	Aminotransferase
M1S21_10835	COG3634	alkyl hydroperoxide reductase activity
M1S21_10850	COG0583	DNA-binding transcription factor activity
M1S21_10855	COG0798	PFAM Bile acid sodium symporter
M1S21_10860	COG0640	Transcriptional regulator
M1S21_10875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S21_10885	COG0583	DNA-binding transcription factor activity
M1S21_10895	COG1953	Uracil, thiamine, allantoin
M1S21_10905	COG2175	clavaminate synthase activity
M1S21_10910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S21_10915	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S21_10920	COG4521	taurine ABC transporter
M1S21_10930	COG0477	Major facilitator Superfamily
M1S21_10950	COG1271	oxidase subunit
M1S21_10955	COG1294	oxidase, subunit
M1S21_10965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S21_10985	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S21_11005	COG3052	prosthetic group binding
M1S21_11010	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S21_11020	COG2814	Major facilitator Superfamily
M1S21_11040	COG1346	cytolysis
M1S21_11050	COG0583	DNA-binding transcription factor activity
M1S21_11055	COG0625	glutathione transferase activity
M1S21_11060	COG0625	glutathione transferase activity
M1S21_11065	COG0583	DNA-binding transcription factor activity
M1S21_11080	COG1045	serine acetyltransferase
M1S21_11085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S21_11090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S21_11100	COG1280	lysine exporter protein (LysE YggA)
M1S21_11115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S21_11120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S21_11125	COG1126	abc transporter atp-binding protein
M1S21_11130	COG0765	amino acid transport
M1S21_11135	COG0765	amino acid transport
M1S21_11155	COG0784	Response regulator, receiver
M1S21_11155	COG2205	protein histidine kinase activity
M1S21_11175	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S21_11195	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_11245	COG0583	DNA-binding transcription factor activity
M1S21_11265	COG0318	PFAM AMP-dependent synthetase and ligase
M1S21_11270	COG1309	transcriptional regulator
M1S21_11275	COG1960	acyl-CoA dehydrogenase activity
M1S21_11280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S21_11285	COG1024	Enoyl-CoA hydratase
M1S21_11290	COG4770	biotin carboxylase activity
M1S21_11300	COG0583	DNA-binding transcription factor activity
M1S21_11315	COG1960	acyl-CoA dehydrogenase activity
M1S21_11325	COG2814	Major facilitator Superfamily
M1S21_11335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S21_11340	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S21_11345	COG2814	Major facilitator Superfamily
M1S21_11350	COG1960	acyl-CoA dehydrogenase activity
M1S21_11355	COG1024	Enoyl-CoA hydratase
M1S21_11360	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_11365	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S21_11370	COG0183	Belongs to the thiolase family
M1S21_11380	COG2814	Major facilitator Superfamily
M1S21_11390	COG1024	Enoyl-CoA hydratase
M1S21_11405	COG1960	acyl-CoA dehydrogenase activity
M1S21_11410	COG2814	Major facilitator Superfamily
M1S21_11415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S21_11420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S21_11435	COG3842	ATPase activity
M1S21_11440	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S21_11450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S21_11455	COG1414	Transcriptional regulator
M1S21_11465	COG0583	DNA-binding transcription factor activity
M1S21_11470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S21_11475	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_11485	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S21_11495	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_11500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S21_11505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S21_11510	COG2267	carboxylic ester hydrolase activity
M1S21_11530	COG3038	cytochrome b561
M1S21_11535	COG0753	catalase activity
M1S21_11570	COG2050	protein possibly involved in aromatic compounds catabolism
M1S21_11580	COG3327	negative regulation of DNA-templated transcription, initiation
M1S21_11585	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S21_11590	COG0183	Belongs to the thiolase family
M1S21_11595	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S21_11600	COG1024	Enoyl-CoA hydratase
M1S21_11605	COG1024	Enoyl-CoA hydratase
M1S21_11610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S21_11615	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S21_11620	COG3396	Phenylacetate-CoA oxygenase
M1S21_11625	COG3460	Phenylacetate-CoA oxygenase
M1S21_11630	COG3396	Phenylacetate-CoA oxygenase
M1S21_11635	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_11635	COG2030	dehydratase
M1S21_11640	COG1760	l-serine dehydratase
M1S21_11645	COG0531	amino acid
M1S21_11650	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_11665	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S21_11675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S21_11695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S21_11705	COG0789	Transcriptional regulator
M1S21_11720	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S21_11735	COG2807	transmembrane transport
M1S21_11740	COG0590	tRNA wobble adenosine to inosine editing
M1S21_11860	COG1116	anion transmembrane transporter activity
M1S21_11865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S21_11875	COG0864	Transcriptional regulator
M1S21_11895	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S21_11900	COG0439	Biotin carboxylase
M1S21_11915	COG1063	alcohol dehydrogenase
M1S21_11925	COG1309	transcriptional regulator
M1S21_11945	COG0038	chloride channel
M1S21_11950	COG4770	biotin carboxylase activity
M1S21_11970	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S21_11975	COG0583	DNA-binding transcription factor activity
M1S21_12025	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S21_12045	COG2814	Major facilitator Superfamily
M1S21_12060	COG1560	Kdo2-lipid A biosynthetic process
M1S21_12070	COG5006	permease, DMT superfamily
M1S21_12075	COG1522	sequence-specific DNA binding
M1S21_12090	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S21_12100	COG4122	O-methyltransferase activity
M1S21_12130	COG1538	Outer membrane efflux protein
M1S21_12135	COG1137	ATPase activity
M1S21_12140	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S21_12150	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S21_12155	COG0517	IMP dehydrogenase activity
M1S21_12155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S21_12190	COG2814	Major facilitator Superfamily
M1S21_12225	COG1278	Cold shock
M1S21_12230	COG1280	lysine exporter protein (LysE YggA)
M1S21_12260	COG1570	exodeoxyribonuclease VII activity
M1S21_12310	COG0583	DNA-binding transcription factor activity
M1S21_12320	COG4638	Rieske (2fe-2S)
M1S21_12325	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S21_12330	COG0543	2 iron, 2 sulfur cluster binding
M1S21_12330	COG0633	Ferredoxin
M1S21_12335	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_12340	COG3135	benzoate transporter
M1S21_12345	COG2814	Major facilitator Superfamily
M1S21_12360	COG1643	Atp-dependent helicase
M1S21_12365	COG0450	alkyl hydroperoxide reductase
M1S21_12375	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S21_12385	COG3634	alkyl hydroperoxide reductase activity
M1S21_12405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S21_12410	COG0625	glutathione transferase activity
M1S21_12420	COG2885	chlorophyll binding
M1S21_12455	COG0542	response to heat
M1S21_12470	COG1765	OsmC-like protein
M1S21_12490	COG0667	Aldo Keto reductase
M1S21_12505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S21_12515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S21_12525	COG0527	aspartate kinase activity
M1S21_12535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S21_12545	COG3038	cytochrome b561
M1S21_12550	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S21_12555	COG2252	PERMEase
M1S21_12565	COG2072	flavoprotein involved in K transport
M1S21_12575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S21_12625	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_12645	COG0531	amino acid
M1S21_12655	COG1113	amino acid transport
M1S21_12695	COG3209	COG3209 Rhs family protein
M1S21_12725	COG4269	membrane
M1S21_12740	COG1902	pentaerythritol trinitrate reductase activity
M1S21_12740	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S21_12750	COG4251	negative regulation of phosphorylation
M1S21_12750	COG2203	Gaf domain
M1S21_12750	COG5001	Diguanylate cyclase
M1S21_12750	COG3706	GGDEF domain
M1S21_12760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S21_12780	COG4172	Belongs to the ABC transporter superfamily
M1S21_12785	COG4239	(ABC) transporter, permease
M1S21_12790	COG4174	ABC transporter (Permease)
M1S21_12800	COG0741	lytic transglycosylase activity
M1S21_12800	COG0741	lytic transglycosylase activity
M1S21_12800	COG1388	LysM domain
M1S21_12800	COG1388	LysM domain
M1S21_12805	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S21_12845	COG0583	DNA-binding transcription factor activity
M1S21_12850	COG1279	arginine transmembrane transporter activity
M1S21_12870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S21_12875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S21_12880	COG0006	proline dipeptidase activity
M1S21_12965	COG1196	nuclear chromosome segregation
M1S21_12965	COG0739	heme binding
M1S21_12965	COG0741	lytic transglycosylase activity
M1S21_13025	COG4695	Portal protein
M1S21_13130	COG0305	Participates in initiation and elongation during chromosome replication
M1S21_13145	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S21_13200	COG2194	sulfuric ester hydrolase activity
M1S21_13245	COG0739	heme binding
M1S21_13570	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S21_13595	COG3384	dioxygenase
M1S21_13605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S21_13610	COG2878	Part of a membrane complex involved in electron transport
M1S21_13615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S21_13640	COG0768	penicillin binding
M1S21_13645	COG0742	ribosomal rna small subunit methyltransferase
M1S21_13660	COG0830	nickel cation binding
M1S21_13670	COG0804	urea catabolic process
M1S21_13710	COG1253	flavin adenine dinucleotide binding
M1S21_13715	COG2851	Citrate transporter
M1S21_13765	COG1773	rubredoxin
M1S21_13770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S21_13780	COG0583	DNA-binding transcription factor activity
M1S21_13805	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S21_13810	COG4181	ATPase activity
M1S21_13855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S21_13875	COG0306	phosphate transporter
M1S21_13885	COG3958	Transketolase
M1S21_13890	COG3959	Transketolase, thiamine diphosphate binding domain
M1S21_13895	COG2271	Major facilitator Superfamily
M1S21_13900	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_13905	COG0583	DNA-binding transcription factor activity
M1S21_13920	COG2223	nitrite transmembrane transporter activity
M1S21_13925	COG2207	Transcriptional regulator
M1S21_13930	COG2066	Belongs to the glutaminase family
M1S21_13935	COG0242	peptide deformylase activity
M1S21_13940	COG0477	Major facilitator Superfamily
M1S21_13950	COG0028	Belongs to the TPP enzyme family
M1S21_13965	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_13970	COG2267	carboxylic ester hydrolase activity
M1S21_13980	COG2271	Major facilitator Superfamily
M1S21_13985	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S21_13995	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_14015	COG1414	Transcriptional regulator
M1S21_14030	COG1024	Enoyl-CoA hydratase
M1S21_14040	COG1215	transferase activity, transferring glycosyl groups
M1S21_14045	COG0726	polysaccharide deacetylase
M1S21_14045	COG1649	PFAM Uncharacterised BCR, COG1649
M1S21_14055	COG4681	YaeQ
M1S21_14065	COG0523	cobalamin synthesis protein
M1S21_14075	COG1607	acyl-coa hydrolase
M1S21_14085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S21_14090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S21_14095	COG1309	transcriptional regulator
M1S21_14120	COG2040	homocysteine
M1S21_14125	COG0531	amino acid
M1S21_14180	COG1595	DNA-templated transcription, initiation
M1S21_14190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S21_14195	COG0477	Major facilitator Superfamily
M1S21_14215	COG0084	hydrolase, TatD family'
M1S21_14250	COG0629	single-stranded DNA binding
M1S21_14305	COG0582	viral genome integration into host DNA
M1S21_14395	COG0592	DNA-directed DNA polymerase activity
M1S21_14435	COG2026	Addiction module toxin, RelE StbE family
M1S21_14585	COG3755	Protein conserved in bacteria
M1S21_14630	COG1484	DNA-dependent DNA replication
M1S21_14720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S21_14785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S21_14915	COG1802	Transcriptional regulator
M1S21_14915	COG4626	Terminase
M1S21_15005	COG0582	viral genome integration into host DNA
M1S21_15020	COG2814	Major facilitator Superfamily
M1S21_15030	COG2050	protein possibly involved in aromatic compounds catabolism
M1S21_15045	COG1090	epimerase
M1S21_15065	COG0420	3'-5' exonuclease activity
M1S21_15090	COG0735	belongs to the Fur family
M1S21_15095	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S21_15115	COG0121	glutamine amidotransferase
M1S21_15130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S21_15140	COG0210	DNA helicase
M1S21_15145	COG2885	chlorophyll binding
M1S21_15150	COG0204	Acyl-transferase
M1S21_15165	COG2894	cell division
M1S21_15190	COG1280	lysine exporter protein (LysE YggA)
M1S21_15195	COG1674	ftsk spoiiie
M1S21_15195	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S21_15200	COG0492	ferredoxin-NADP+ reductase activity
M1S21_15205	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S21_15215	COG0456	acetyltransferase
M1S21_15260	COG1981	membrane
M1S21_15275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S21_15275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S21_15295	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_15305	COG0657	acetylesterase activity
M1S21_15315	COG0473	3-isopropylmalate dehydrogenase activity
M1S21_15320	COG0583	DNA-binding transcription factor activity
M1S21_15340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S21_15365	COG0564	pseudouridine synthase activity
M1S21_15375	COG0358	DNA primase activity
M1S21_15390	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S21_15420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S21_15450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S21_15460	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S21_15460	COG0352	thiamine-phosphate diphosphorylase activity
M1S21_15460	COG0351	phosphomethylpyrimidine kinase
M1S21_15465	COG1652	LysM domain
M1S21_15490	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S21_15495	COG3101	peptidyl-lysine hydroxylation
M1S21_15500	COG0009	L-threonylcarbamoyladenylate synthase
M1S21_15505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S21_15510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S21_15525	COG4106	trans-aconitate 2-methyltransferase activity
M1S21_15540	COG0596	Alpha beta hydrolase
M1S21_15540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S21_15540	COG2226	methyltransferase
M1S21_15545	COG1877	trehalose-phosphatase activity
M1S21_15550	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S21_15555	COG2223	nitrite transmembrane transporter activity
M1S21_15575	COG1196	nuclear chromosome segregation
M1S21_15585	COG0730	response to heat
M1S21_15600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S21_15610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S21_15660	COG0489	protein tyrosine kinase activity
M1S21_15670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S21_15670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S21_15700	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S21_15705	COG2081	HI0933 family
M1S21_15715	COG0668	transmembrane transport
M1S21_15735	COG0583	DNA-binding transcription factor activity
M1S21_15755	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S21_15760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S21_15790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S21_15830	COG0745	RESPONSE REGULATOR receiver
M1S21_15850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S21_15860	COG2205	protein histidine kinase activity
M1S21_15930	COG4993	Dehydrogenase
M1S21_15955	COG0384	phenazine biosynthesis protein PhzF
M1S21_15980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S21_15995	COG0583	DNA-binding transcription factor activity
M1S21_16025	COG0583	DNA-binding transcription factor activity
M1S21_16040	COG0583	DNA-binding transcription factor activity
M1S21_16045	COG1053	succinate dehydrogenase
M1S21_16055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S21_16060	COG2814	Major facilitator Superfamily
M1S21_16065	COG1960	acyl-CoA dehydrogenase activity
M1S21_16070	COG0583	DNA-binding transcription factor activity
M1S21_16075	COG1063	alcohol dehydrogenase
M1S21_16105	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S21_16110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S21_16115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S21_16130	COG3667	copper resistance
M1S21_16135	COG2132	Multicopper oxidase
M1S21_16145	COG0561	phosphatase activity
M1S21_16150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S21_16175	COG1214	PFAM Peptidase M22, glycoprotease
M1S21_16225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S21_16235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S21_16240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S21_16245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S21_16305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S21_16315	COG1846	Transcriptional regulator
M1S21_16320	COG1764	response to oxidative stress
M1S21_16360	COG0037	tRNA processing
M1S21_16370	COG0248	Ppx GppA phosphatase
M1S21_16400	COG0072	phenylalanine-tRNA ligase activity
M1S21_16445	COG1238	metal cluster binding
M1S21_16450	COG0625	glutathione transferase activity
M1S21_16465	COG0318	PFAM AMP-dependent synthetase and ligase
M1S21_16470	COG3028	Belongs to the UPF0307 family
M1S21_16475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S21_16495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S21_16500	COG0617	tRNA 3'-terminal CCA addition
M1S21_16505	COG1555	photosystem II stabilization
M1S21_16510	COG3956	TIGRFAM MazG family protein
M1S21_16520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S21_16540	COG0784	Response regulator, receiver
M1S21_16540	COG2205	protein histidine kinase activity
M1S21_16540	COG5002	protein histidine kinase activity
M1S21_16545	COG1024	Enoyl-CoA hydratase
M1S21_16550	COG2084	Dehydrogenase
M1S21_16555	COG3622	Belongs to the hyi family
M1S21_16585	COG0697	spore germination
M1S21_16595	COG2814	Major facilitator Superfamily
M1S21_16600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S21_16610	COG0583	DNA-binding transcription factor activity
M1S21_16620	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S21_16635	COG0084	hydrolase, TatD family'
M1S21_16650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S21_16680	COG0440	acetolactate synthase activity
M1S21_16685	COG0028	Belongs to the TPP enzyme family
M1S21_16710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S21_16715	COG0577	efflux transmembrane transporter activity
M1S21_16715	COG1136	(ABC) transporter
M1S21_16720	COG1538	Outer membrane efflux protein
M1S21_16735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S21_16740	COG1162	GTPase activity
M1S21_16750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S21_16770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S21_16775	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_16815	COG2986	histidine ammonia-lyase
M1S21_16830	COG0318	PFAM AMP-dependent synthetase and ligase
M1S21_16840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S21_16885	COG1426	Protein conserved in bacteria
M1S21_16920	COG0793	Belongs to the peptidase S41A family
M1S21_16935	COG2267	carboxylic ester hydrolase activity
M1S21_16945	COG1012	belongs to the aldehyde dehydrogenase family
M1S21_16950	COG3265	gluconokinase activity
M1S21_16960	COG0800	Aldolase
M1S21_16970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S21_16975	COG0857	belongs to the CobB CobQ family
M1S21_16975	COG0280	phosphate acetyltransferase
M1S21_16980	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S21_16980	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S21_17000	COG0740	serine-type endopeptidase activity
M1S21_17010	COG4774	siderophore transport
M1S21_17020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S21_17030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S21_17030	COG2813	Specifically methylates the guanine in position
M1S21_17130	COG0788	formyltetrahydrofolate deformylase activity
M1S21_17155	COG4651	solute:proton antiporter activity
M1S21_17155	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S21_17175	COG0724	RNA recognition motif
M1S21_17180	COG0210	DNA helicase
M1S21_17205	COG1733	regulation of RNA biosynthetic process
M1S21_17215	COG2900	Belongs to the SlyX family
M1S21_17220	COG0488	(ABC) transporter
M1S21_17225	COG1280	lysine exporter protein (LysE YggA)
M1S21_17230	COG1560	Kdo2-lipid A biosynthetic process
M1S21_17240	COG1301	dicarboxylic acid transport
M1S21_17295	COG0473	3-isopropylmalate dehydrogenase activity
M1S21_17360	COG0583	DNA-binding transcription factor activity
M1S21_17370	COG0625	glutathione transferase activity
M1S21_17375	COG2378	regulation of single-species biofilm formation
M1S21_17380	COG0546	phosphoglycolate phosphatase activity
M1S21_17390	COG1530	ribonuclease E activity
M1S21_17395	COG0318	PFAM AMP-dependent synthetase and ligase
M1S21_17410	COG0583	DNA-binding transcription factor activity
M1S21_17415	COG4221	oxidoreductase activity
M1S21_17420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S21_17430	COG0534	Mate efflux family protein
M1S21_17445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S21_17485	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S21_17490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S21_17505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S21_17515	COG0644	oxidoreductase
M1S21_17515	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S21_17520	COG0425	Belongs to the sulfur carrier protein TusA family
M1S21_17525	COG4535	Mg2 and Co2 transporter CorC
M1S21_17535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S21_17555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S21_17560	COG0475	glutathione-regulated potassium exporter activity
M1S21_17560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S21_17565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S21_17575	COG0484	heat shock protein binding
M1S21_17580	COG0789	Transcriptional regulator
M1S21_17585	COG0598	Magnesium transport protein CorA
M1S21_17600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S21_17605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S21_17610	COG1074	ATP-dependent DNA helicase activity
M1S21_17615	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S21_17635	COG2226	methyltransferase
M1S21_17650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S21_17655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S21_17670	COG2111	Na H antiporter
M1S21_17670	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S21_17675	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S21_17680	COG0651	ATP synthesis coupled electron transport
M1S21_17685	COG1863	multisubunit Na H antiporter MnhE subunit
M1S21_17690	COG2212	antiporter activity
M1S21_17695	COG1320	monovalent cation:proton antiporter activity
M1S21_17710	COG0195	Participates in both transcription termination and antitermination
M1S21_17760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S21_17765	COG0237	dephospho-CoA kinase activity
M1S21_17775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S21_17790	COG0497	DNA recombination
M1S21_17800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S21_17830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S21_17830	COG2169	Transcriptional regulator
M1S21_17835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S21_17900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S21_17915	COG0326	Molecular chaperone. Has ATPase activity
M1S21_17930	COG2056	Na+-H+ antiporter family
M1S21_17935	COG0596	Alpha beta hydrolase
M1S21_18030	COG0546	phosphoglycolate phosphatase activity
M1S21_18035	COG1716	ATPase activity
M1S21_18080	COG0181	hydroxymethylbilane synthase activity
M1S21_18090	COG3275	phosphorelay sensor kinase activity
M1S21_18110	COG1538	Outer membrane efflux protein
M1S21_18115	COG0697	spore germination
M1S21_18140	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S21_18145	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S21_18150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S21_18155	COG0772	Belongs to the SEDS family
M1S21_18180	COG4974	Belongs to the 'phage' integrase family
M1S21_18185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S21_18195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S21_18205	COG2197	response regulator
M1S21_18220	COG0793	Belongs to the peptidase S41A family
M1S21_18225	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S21_18230	COG0795	lipopolysaccharide-transporting ATPase activity
M1S21_18270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S21_18270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S21_18280	COG0004	ammonium transporteR
M1S21_18285	COG0347	Belongs to the P(II) protein family
M1S21_18345	COG0659	secondary active sulfate transmembrane transporter activity
M1S21_18350	COG0589	response to stress
M1S21_18385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S21_18395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S21_18415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S21_18430	COG0318	PFAM AMP-dependent synthetase and ligase
M1S21_18440	COG0477	Major facilitator Superfamily
M1S21_18445	COG2860	membrane
M1S21_18455	COG1253	flavin adenine dinucleotide binding
M1S21_18475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S21_18515	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S21_18525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S21_18595	COG0758	DNA mediated transformation
M1S21_18605	COG0697	spore germination
M1S21_18610	COG1309	transcriptional regulator
M1S21_18625	COG0386	Belongs to the glutathione peroxidase family
M1S21_18690	COG1121	(ABC) transporter
M1S21_18695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S21_18700	COG1280	lysine exporter protein (LysE YggA)
M1S21_18705	COG2837	iron assimilation
M1S21_18715	COG0281	malic enzyme
M1S21_18760	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S21_18760	COG0519	Catalyzes the synthesis of GMP from XMP
M1S21_18765	COG4399	Belongs to the UPF0754 family
M1S21_18770	COG2259	Doxx family
M1S21_18775	COG0586	Pfam SNARE associated Golgi protein
M1S21_18790	COG1192	Involved in chromosome partitioning
M1S21_18800	COG0271	Belongs to the BolA IbaG family
M1S21_18820	COG2267	carboxylic ester hydrolase activity
M1S21_18840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S21_18840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S21_18840	COG3321	synthase
M1S21_18840	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S21_18845	COG1960	acyl-CoA dehydrogenase activity
M1S21_18855	COG2197	response regulator
M1S21_18865	COG3916	Acyl-homoserine-lactone synthase
M1S21_18870	COG0477	Major facilitator Superfamily
M1S21_18875	COG1024	Enoyl-CoA hydratase
M1S21_18880	COG1024	Enoyl-CoA hydratase
M1S21_18885	COG1960	acyl-CoA dehydrogenase activity
M1S21_18890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S21_18910	COG1113	amino acid transport
M1S21_18915	COG1113	amino acid transport
M1S21_18920	COG0251	oxidation-reduction process
M1S21_18960	COG0564	pseudouridine synthase activity
M1S21_19020	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S21_19035	COG1802	Transcriptional regulator
M1S21_19045	COG1448	Aminotransferase
M1S21_19050	COG0277	FAD linked oxidase domain protein
M1S21_19060	COG2186	Transcriptional regulator
M1S21_19070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S21_19075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S21_19090	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S21_19095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S21_19100	COG1216	Glycosyl transferase, family 2
M1S21_19130	COG2089	acid synthase
M1S21_19145	COG1083	cytidylyl-transferase
M1S21_19150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S21_19155	COG1086	Polysaccharide biosynthesis protein
M1S21_19160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S21_19165	COG1596	polysaccharide export
M1S21_19190	COG0728	peptidoglycan biosynthetic process
M1S21_19195	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S21_19255	COG0546	phosphoglycolate phosphatase activity
M1S21_19260	COG1028	Short-chain dehydrogenase reductase Sdr
M1S21_19280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S21_19285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S21_19290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S21_19295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S21_19300	COG1116	anion transmembrane transporter activity
M1S21_19305	COG1309	transcriptional regulator
M1S21_19310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S21_19320	COG0196	riboflavin kinase activity
M1S21_19325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S21_19335	COG1047	Peptidyl-prolyl cis-trans
M1S21_19375	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S21_19380	COG0657	acetylesterase activity
M1S21_19400	COG0583	DNA-binding transcription factor activity
M1S21_19430	COG2951	lytic endotransglycosylase activity
M1S21_19435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S21_19450	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S21_19460	COG0671	phosphoesterase, PA-phosphatase related
M1S21_19465	COG0861	Integral membrane protein TerC family
M1S21_19475	COG0754	glutathionylspermidine amidase activity
M1S21_19485	COG0402	S-adenosylhomocysteine deaminase activity
M1S21_19500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S21_19505	COG1230	cation diffusion facilitator family transporter
M1S21_19520	COG0706	membrane insertase activity
M1S21_19560	COG0358	DNA primase activity
M1S21_19615	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S21_19660	COG0587	DNA-directed DNA polymerase activity
M1S21_19675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S21_19675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S21_19725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S21_19725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S21_19730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S21_19770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S21_19815	COG1309	transcriptional regulator
M1S21_19825	COG1902	pentaerythritol trinitrate reductase activity
M1S21_19835	COG1979	alcohol dehydrogenase
M1S21_19850	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S21_19875	COG1063	alcohol dehydrogenase
M1S21_19955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S21_19975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S21_20135	COG1192	Involved in chromosome partitioning
M1S21_20210	COG1061	Type III restriction enzyme res subunit
M1S21_20220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S21_20225	COG1192	Involved in chromosome partitioning
M1S21_20290	COG0484	heat shock protein binding
M1S21_20420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S21_20540	COG1525	nuclease
M1S21_20630	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
M1S21_20695	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
M1S21_20790	COG4683	PFAM Phage derived protein Gp49-like (DUF891)