locus-tag	class	description
M1S19_00010	COG0592	DNA-directed DNA polymerase activity
M1S19_00020	COG0187	DNA topoisomerase II activity
M1S19_00030	COG0586	Pfam SNARE associated Golgi protein
M1S19_00035	COG0488	(ABC) transporter
M1S19_00060	COG0596	Alpha beta hydrolase
M1S19_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S19_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S19_00110	COG0733	neurotransmitter:sodium symporter activity
M1S19_00150	COG2233	PERMEase
M1S19_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S19_00200	COG2814	Major facilitator Superfamily
M1S19_00205	COG0656	L-ascorbic acid biosynthetic process
M1S19_00210	COG0583	DNA-binding transcription factor activity
M1S19_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S19_00230	COG1064	alcohol dehydrogenase
M1S19_00235	COG2818	Glycosylase
M1S19_00250	COG1194	a g-specific adenine glycosylase
M1S19_00270	COG2983	Belongs to the UPF0260 family
M1S19_00275	COG2133	pyrroloquinoline quinone binding
M1S19_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S19_00285	COG2116	formate transmembrane transporter activity
M1S19_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S19_00310	COG1335	isochorismatase
M1S19_00315	COG0385	Bile acid
M1S19_00320	COG0534	Mate efflux family protein
M1S19_00325	COG1683	Conserved Protein
M1S19_00345	COG0625	glutathione transferase activity
M1S19_00355	COG1113	amino acid transport
M1S19_00365	COG0523	cobalamin synthesis protein
M1S19_00375	COG2188	Transcriptional regulator
M1S19_00405	COG0010	Belongs to the arginase family
M1S19_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S19_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S19_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S19_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S19_00540	COG0534	Mate efflux family protein
M1S19_00545	COG0436	Aminotransferase
M1S19_00550	COG2733	membrane
M1S19_00565	COG2918	glutathione biosynthetic process
M1S19_00580	COG1388	LysM domain
M1S19_00580	COG0791	NLP P60 protein
M1S19_00595	COG3150	esterase
M1S19_00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S19_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S19_00630	COG2233	PERMEase
M1S19_00635	COG2351	hydroxyisourate hydrolase activity
M1S19_00670	COG3706	GGDEF domain
M1S19_00685	COG1393	Belongs to the ArsC family
M1S19_00690	COG0708	Exodeoxyribonuclease III
M1S19_00710	COG0189	ligase activity
M1S19_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S19_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S19_00755	COG4942	peptidase
M1S19_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S19_00775	COG2119	membrane
M1S19_00780	COG4774	siderophore transport
M1S19_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S19_00785	COG0426	domain, Protein
M1S19_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S19_00830	COG1902	pentaerythritol trinitrate reductase activity
M1S19_00835	COG1519	Transferase
M1S19_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S19_00845	COG0668	transmembrane transport
M1S19_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S19_00860	COG1335	isochorismatase
M1S19_00865	COG1522	sequence-specific DNA binding
M1S19_00870	COG3328	transposase activity
M1S19_00895	COG2198	Histidine kinase
M1S19_00895	COG2205	protein histidine kinase activity
M1S19_00895	COG0784	Response regulator, receiver
M1S19_00900	COG3162	membrane
M1S19_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S19_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S19_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S19_00940	COG1309	transcriptional regulator
M1S19_00965	COG0351	phosphomethylpyrimidine kinase
M1S19_00965	COG0352	thiamine-phosphate diphosphorylase activity
M1S19_00965	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S19_00975	COG2814	Major facilitator Superfamily
M1S19_00990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S19_01000	COG1113	amino acid transport
M1S19_01010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S19_01015	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_01025	COG1335	isochorismatase
M1S19_01055	COG2814	Major facilitator Superfamily
M1S19_01060	COG0583	DNA-binding transcription factor activity
M1S19_01080	COG0667	Aldo Keto reductase
M1S19_01115	COG1733	regulation of RNA biosynthetic process
M1S19_01120	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S19_01185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S19_01200	COG2329	Antibiotic biosynthesis monooxygenase
M1S19_01230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S19_01260	COG0427	acetyl-CoA hydrolase
M1S19_01285	COG0659	secondary active sulfate transmembrane transporter activity
M1S19_01290	COG4221	oxidoreductase activity
M1S19_01295	COG2873	o-acetylhomoserine
M1S19_01300	COG0488	(ABC) transporter
M1S19_01385	COG0833	amino acid
M1S19_01430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S19_01435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S19_01450	COG2226	methyltransferase
M1S19_01500	COG0069	glutamate synthase activity
M1S19_01500	COG0067	glutamate synthase
M1S19_01500	COG0070	glutamate synthase
M1S19_01505	COG0493	'glutamate synthase
M1S19_01515	COG1704	LemA family
M1S19_01520	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S19_01540	COG3307	-O-antigen
M1S19_01565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S19_01580	COG0194	GDP metabolic process
M1S19_01630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S19_01650	COG5380	lipid catabolic process
M1S19_01655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S19_01680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S19_01685	COG0277	FAD linked oxidase domain protein
M1S19_01695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S19_01700	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S19_01715	COG1289	transmembrane transporter activity
M1S19_01725	COG0628	permease
M1S19_01730	COG1192	Involved in chromosome partitioning
M1S19_01760	COG0833	amino acid
M1S19_01765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S19_01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S19_01780	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_01820	COG0583	DNA-binding transcription factor activity
M1S19_01865	COG0517	IMP dehydrogenase activity
M1S19_01870	COG1983	PspC domain protein
M1S19_01880	COG1960	acyl-CoA dehydrogenase activity
M1S19_01895	COG0408	coproporphyrinogen oxidase activity
M1S19_01915	COG0513	Belongs to the DEAD box helicase family
M1S19_01925	COG1127	ABC transporter
M1S19_01930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S19_01940	COG2854	intermembrane phospholipid transfer
M1S19_01950	COG0598	Magnesium transport protein CorA
M1S19_01960	COG0494	nUDIX hydrolase
M1S19_01965	COG1040	competence protein
M1S19_01970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S19_01990	COG1946	Acyl-CoA thioesterase
M1S19_01995	COG1301	dicarboxylic acid transport
M1S19_02010	COG1959	2 iron, 2 sulfur cluster binding
M1S19_02015	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S19_02015	COG1017	nitric oxide dioxygenase activity
M1S19_02020	COG0433	COG0433 Predicted ATPase
M1S19_02025	COG0626	cystathionine gamma-synthase activity
M1S19_02180	COG1960	acyl-CoA dehydrogenase activity
M1S19_02185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S19_02215	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S19_02220	COG0339	signal peptide processing
M1S19_02225	COG0557	exoribonuclease II activity
M1S19_02270	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S19_02275	COG2169	Transcriptional regulator
M1S19_02280	COG0697	spore germination
M1S19_02285	COG1295	ribonuclease BN
M1S19_02320	COG1702	phosphate starvation-inducible protein PhoH
M1S19_02330	COG0739	heme binding
M1S19_02330	COG0741	lytic transglycosylase activity
M1S19_02330	COG1196	nuclear chromosome segregation
M1S19_02360	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S19_02365	COG1183	phosphatidylcholine synthase activity
M1S19_02410	COG1960	acyl-CoA dehydrogenase activity
M1S19_02415	COG1309	transcriptional regulator
M1S19_02430	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S19_02435	COG1960	acyl-CoA dehydrogenase activity
M1S19_02455	COG2969	positive regulation of protein catabolic process
M1S19_02465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S19_02480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S19_02485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S19_02505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S19_02515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S19_02520	COG1408	metallophosphoesterase
M1S19_02530	COG2199	diguanylate cyclase activity
M1S19_02590	COG1607	acyl-coa hydrolase
M1S19_02620	COG2350	Protein conserved in bacteria
M1S19_02630	COG0613	PHP domain protein
M1S19_02635	COG3781	membrane
M1S19_02645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S19_02650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S19_02660	COG1862	Preprotein translocase
M1S19_02690	COG2205	protein histidine kinase activity
M1S19_02695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S19_02715	COG0726	polysaccharide deacetylase
M1S19_02720	COG0463	Glycosyl transferase, family 2
M1S19_02725	COG0438	transferase activity, transferring glycosyl groups
M1S19_02790	COG0625	glutathione transferase activity
M1S19_02795	COG0583	DNA-binding transcription factor activity
M1S19_02800	COG1960	acyl-CoA dehydrogenase activity
M1S19_02805	COG1960	acyl-CoA dehydrogenase activity
M1S19_02815	COG2205	protein histidine kinase activity
M1S19_02820	COG0745	RESPONSE REGULATOR receiver
M1S19_02825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S19_02845	COG2096	Adenosyltransferase
M1S19_02895	COG0285	dihydrofolate synthase activity
M1S19_02915	COG0450	alkyl hydroperoxide reductase
M1S19_02930	COG0477	Major facilitator Superfamily
M1S19_02935	COG1272	protein, Hemolysin III
M1S19_02965	COG0183	Belongs to the thiolase family
M1S19_02970	COG2207	Transcriptional regulator
M1S19_02990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S19_03010	COG0183	Belongs to the thiolase family
M1S19_03020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S19_03020	COG2885	chlorophyll binding
M1S19_03030	COG1690	Belongs to the RtcB family
M1S19_03035	COG0833	amino acid
M1S19_03045	COG2233	PERMEase
M1S19_03050	COG1217	gtp-binding protein TYPA
M1S19_03075	COG2094	Belongs to the DNA glycosylase MPG family
M1S19_03095	COG1902	pentaerythritol trinitrate reductase activity
M1S19_03110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S19_03115	COG0354	folic acid binding
M1S19_03125	COG3189	MarR family transcriptional regulator
M1S19_03130	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S19_03135	COG3422	double-strand break repair
M1S19_03175	COG0840	transmembrane signaling receptor activity
M1S19_03195	COG5510	response to toxic substance
M1S19_03205	COG2832	Protein of unknown function (DUF454)
M1S19_03210	COG1376	ErfK ybiS ycfS ynhG family protein
M1S19_03250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S19_03260	COG1289	transmembrane transporter activity
M1S19_03265	COG2814	Major facilitator Superfamily
M1S19_03285	COG1115	amino acid carrier protein
M1S19_03290	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S19_03295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S19_03300	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S19_03330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S19_03340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S19_03345	COG1077	Cell shape determining protein MreB Mrl
M1S19_03350	COG1792	Involved in formation and maintenance of cell shape
M1S19_03355	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S19_03360	COG0424	maF-like protein
M1S19_03365	COG1530	ribonuclease E activity
M1S19_03375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S19_03385	COG0560	Phosphoserine phosphatase
M1S19_03395	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S19_03420	COG2207	Transcriptional regulator
M1S19_03440	COG1113	amino acid transport
M1S19_03445	COG2828	Protein conserved in bacteria
M1S19_03450	COG0142	geranyltranstransferase activity
M1S19_03455	COG2315	Protein conserved in bacteria
M1S19_03470	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S19_03490	COG2194	sulfuric ester hydrolase activity
M1S19_03495	COG0745	RESPONSE REGULATOR receiver
M1S19_03500	COG0642	Histidine kinase
M1S19_03510	COG0004	ammonium transporteR
M1S19_03515	COG0583	DNA-binding transcription factor activity
M1S19_03535	COG0525	valine-tRNA ligase activity
M1S19_03545	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_03555	COG0393	Putative heavy-metal-binding
M1S19_03560	COG0393	Putative heavy-metal-binding
M1S19_03565	COG1538	Outer membrane efflux protein
M1S19_03575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S19_03580	COG0671	phosphoesterase, PA-phosphatase related
M1S19_03610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S19_03625	COG1648	precorrin-2 dehydrogenase activity
M1S19_03625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S19_03630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S19_03635	COG1733	regulation of RNA biosynthetic process
M1S19_03645	COG0531	amino acid
M1S19_03660	COG0321	lipoyl(octanoyl) transferase activity
M1S19_03665	COG2921	Belongs to the UPF0250 family
M1S19_03705	COG2009	succinate dehydrogenase
M1S19_03710	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S19_03715	COG1053	succinate dehydrogenase
M1S19_03720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S19_03745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S19_03765	COG2354	Protein conserved in bacteria
M1S19_03770	COG2321	neutral zinc metallopeptidase
M1S19_03790	COG2843	Capsule synthesis protein
M1S19_03805	COG0589	response to stress
M1S19_03825	COG0505	Belongs to the CarA family
M1S19_03850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S19_03855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S19_03905	COG0477	Major facilitator Superfamily
M1S19_03910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S19_03925	COG1597	lipid kinase activity
M1S19_03930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S19_03960	COG0584	glycerophosphoryl diester phosphodiesterase
M1S19_03980	COG0741	lytic transglycosylase activity
M1S19_04000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S19_04015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S19_04045	COG0778	Nitroreductase
M1S19_04060	COG1929	Belongs to the glycerate kinase type-1 family
M1S19_04065	COG0243	molybdopterin cofactor binding
M1S19_04070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S19_04075	COG3339	Conserved Protein
M1S19_04085	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S19_04100	COG1113	amino acid transport
M1S19_04110	COG0019	diaminopimelate decarboxylase activity
M1S19_04120	COG1280	lysine exporter protein (LysE YggA)
M1S19_04125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S19_04155	COG0463	Glycosyl transferase, family 2
M1S19_04175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S19_04210	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S19_04215	COG1136	(ABC) transporter
M1S19_04220	COG2333	competence protein COMEC
M1S19_04220	COG0658	competence protein
M1S19_04230	COG0616	signal peptide processing
M1S19_04230	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S19_04235	COG0596	Alpha beta hydrolase
M1S19_04240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S19_04250	COG0628	permease
M1S19_04285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S19_04305	COG0823	Involved in the tonB-independent uptake of proteins
M1S19_04325	COG0824	Thioesterase
M1S19_04330	COG1473	amidohydrolase
M1S19_04350	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S19_04350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S19_04355	COG2814	Major facilitator Superfamily
M1S19_04365	COG1024	Enoyl-CoA hydratase
M1S19_04370	COG1056	cytidyltransferase-related domain
M1S19_04370	COG1051	belongs to the nudix hydrolase family
M1S19_04380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S19_04395	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S19_04410	COG4625	pathogenesis
M1S19_04415	COG0583	DNA-binding transcription factor activity
M1S19_04420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S19_04425	COG4208	sulfate ABC transporter
M1S19_04430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S19_04440	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S19_04445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S19_04450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S19_04470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S19_04485	COG0681	Belongs to the peptidase S26 family
M1S19_04500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S19_04510	COG1381	Involved in DNA repair and RecF pathway recombination
M1S19_04515	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S19_04525	COG4221	oxidoreductase activity
M1S19_04555	COG0436	Aminotransferase
M1S19_04575	COG0556	nucleotide-excision repair
M1S19_04630	COG2070	2-Nitropropane dioxygenase
M1S19_04660	COG1215	transferase activity, transferring glycosyl groups
M1S19_04675	COG0415	Belongs to the DNA photolyase family
M1S19_04685	COG1252	NADH dehydrogenase
M1S19_04690	COG1686	Belongs to the peptidase S11 family
M1S19_04705	COG1187	pseudouridine synthase activity
M1S19_04730	COG0477	Major facilitator Superfamily
M1S19_04735	COG0583	DNA-binding transcription factor activity
M1S19_04740	COG1823	symporter activity
M1S19_04750	COG0612	Peptidase, M16
M1S19_04775	COG0352	thiamine-phosphate diphosphorylase activity
M1S19_04810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S19_04825	COG1309	transcriptional regulator
M1S19_04835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S19_04840	COG0076	glutamate decarboxylase activity
M1S19_04850	COG1522	sequence-specific DNA binding
M1S19_04855	COG3961	Belongs to the TPP enzyme family
M1S19_04860	COG1113	amino acid transport
M1S19_04865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S19_04870	COG0573	inorganic phosphate transmembrane transporter activity
M1S19_04880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S19_04885	COG0616	signal peptide processing
M1S19_04920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S19_04925	COG1686	Belongs to the peptidase S11 family
M1S19_04950	COG0583	DNA-binding transcription factor activity
M1S19_04955	COG1067	ATP-dependent peptidase activity
M1S19_05000	COG1966	Carbon starvation protein
M1S19_05005	COG2879	small protein
M1S19_05040	COG2508	Transcriptional regulator
M1S19_05040	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S19_05065	COG1113	amino acid transport
M1S19_05070	COG0583	DNA-binding transcription factor activity
M1S19_05075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S19_05080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S19_05090	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_05100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S19_05105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S19_05105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S19_05140	COG2814	Major facilitator Superfamily
M1S19_05145	COG4948	Mandelate Racemase Muconate Lactonizing
M1S19_05155	COG1309	transcriptional regulator
M1S19_05175	COG1741	Belongs to the pirin family
M1S19_05185	COG2964	Protein conserved in bacteria
M1S19_05200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S19_05205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S19_05210	COG4605	iron ion homeostasis
M1S19_05215	COG4604	ABC transporter, ATP-binding protein
M1S19_05220	COG4607	ABC-type enterochelin transport system periplasmic component
M1S19_05225	COG4774	siderophore transport
M1S19_05235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S19_05240	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S19_05245	COG1535	isochorismatase
M1S19_05245	COG3433	isochorismatase activity
M1S19_05260	COG1132	(ABC) transporter
M1S19_05265	COG1132	(ABC) transporter
M1S19_05270	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S19_05280	COG1169	isochorismate synthase
M1S19_05295	COG3739	integral membrane protein
M1S19_05320	COG0302	gtp cyclohydrolase
M1S19_05330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S19_05360	COG0308	aminopeptidase N
M1S19_05365	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S19_05380	COG0174	glutamine synthetase
M1S19_05390	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S19_05425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S19_05430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S19_05435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S19_05455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S19_05460	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S19_05465	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S19_05480	COG1960	acyl-CoA dehydrogenase activity
M1S19_05485	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S19_05490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S19_05500	COG2223	nitrite transmembrane transporter activity
M1S19_05510	COG0024	Methionine aminopeptidase
M1S19_05515	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S19_05530	COG2207	Transcriptional regulator
M1S19_05555	COG2951	lytic endotransglycosylase activity
M1S19_05560	COG0772	Belongs to the SEDS family
M1S19_05575	COG0842	Transport permease protein
M1S19_05580	COG1131	(ABC) transporter
M1S19_05625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S19_05640	COG4215	(ABC) transporter
M1S19_05645	COG4160	amino acid transport
M1S19_05650	COG4598	ABC transporter
M1S19_05660	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S19_05665	COG0826	peptidase U32
M1S19_05670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S19_05685	COG1720	tRNA m6t6A37 methyltransferase activity
M1S19_05695	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S19_05710	COG0642	Histidine kinase
M1S19_05720	COG0494	nUDIX hydrolase
M1S19_05730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S19_05735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S19_05740	COG3139	Protein of unknown function (DUF1315)
M1S19_05745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S19_05750	COG1301	dicarboxylic acid transport
M1S19_05755	COG1960	acyl-CoA dehydrogenase activity
M1S19_05760	COG2819	hydrolase of the alpha beta superfamily
M1S19_05770	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S19_05780	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S19_05785	COG1234	tRNA 3'-trailer cleavage
M1S19_05815	COG2363	Small membrane protein
M1S19_05840	COG0513	Belongs to the DEAD box helicase family
M1S19_05850	COG0778	Nitroreductase
M1S19_06200	COG1286	toxin biosynthetic process
M1S19_06225	COG4783	chaperone-mediated protein folding
M1S19_06230	COG1610	YqeY-like protein
M1S19_06330	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S19_06355	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S19_06360	COG0786	glutamate:sodium symporter activity
M1S19_06370	COG2186	Transcriptional regulator
M1S19_06435	COG1301	dicarboxylic acid transport
M1S19_06445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S19_06450	COG2011	ABC-type metal ion transport system permease component
M1S19_06455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S19_06460	COG1464	Belongs to the NlpA lipoprotein family
M1S19_06465	COG0151	Belongs to the GarS family
M1S19_06470	COG0138	bifunctional purine biosynthesis protein purh
M1S19_06475	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S19_06505	COG2308	Evidence 4 Homologs of previously reported genes of
M1S19_06515	COG1305	Transglutaminase-like
M1S19_06525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S19_06530	COG0305	Participates in initiation and elongation during chromosome replication
M1S19_06555	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S19_06565	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S19_06570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S19_06595	COG0726	polysaccharide deacetylase
M1S19_06595	COG1649	PFAM Uncharacterised BCR, COG1649
M1S19_06600	COG1215	transferase activity, transferring glycosyl groups
M1S19_06605	COG3658	cytochrome
M1S19_06615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S19_06630	COG0583	DNA-binding transcription factor activity
M1S19_06650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S19_06655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S19_06670	COG1960	acyl-CoA dehydrogenase activity
M1S19_06675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S19_06680	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S19_06705	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S19_06710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S19_06720	COG2205	protein histidine kinase activity
M1S19_06725	COG0745	RESPONSE REGULATOR receiver
M1S19_06730	COG0174	glutamine synthetase
M1S19_06750	COG0729	surface antigen
M1S19_06775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S19_06780	COG2814	Major facilitator Superfamily
M1S19_06795	COG0583	DNA-binding transcription factor activity
M1S19_06810	COG1187	pseudouridine synthase activity
M1S19_06830	COG0802	atpase or kinase
M1S19_06835	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S19_06845	COG1923	regulation of RNA biosynthetic process
M1S19_06850	COG0697	spore germination
M1S19_06865	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S19_06875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S19_06880	COG0519	Catalyzes the synthesis of GMP from XMP
M1S19_06880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S19_06885	COG4302	ethanolamine ammonia-lyase activity
M1S19_06890	COG4303	Ethanolamine ammonia lyase large subunit
M1S19_06895	COG0531	amino acid
M1S19_06915	COG1454	alcohol dehydrogenase
M1S19_06920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S19_06930	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S19_06950	COG0308	aminopeptidase N
M1S19_06960	COG4221	oxidoreductase activity
M1S19_06970	COG1605	Chorismate mutase
M1S19_06990	COG1309	transcriptional regulator
M1S19_07000	COG0668	transmembrane transport
M1S19_07035	COG4773	Receptor
M1S19_07055	COG0488	(ABC) transporter
M1S19_07060	COG0589	response to stress
M1S19_07085	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S19_07095	COG3135	benzoate transporter
M1S19_07100	COG1522	sequence-specific DNA binding
M1S19_07110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S19_07115	COG0583	DNA-binding transcription factor activity
M1S19_07125	COG0183	Belongs to the thiolase family
M1S19_07135	COG2030	dehydratase
M1S19_07140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S19_07155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S19_07165	COG0824	Thioesterase
M1S19_07170	COG1454	alcohol dehydrogenase
M1S19_07180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S19_07200	COG0069	glutamate synthase activity
M1S19_07380	COG5410	chromosome segregation
M1S19_07520	COG0739	heme binding
M1S19_07520	COG0741	lytic transglycosylase activity
M1S19_07520	COG1196	nuclear chromosome segregation
M1S19_07590	COG2814	Major facilitator Superfamily
M1S19_07605	COG0511	ligase activity, forming carbon-carbon bonds
M1S19_07625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S19_07625	COG1116	anion transmembrane transporter activity
M1S19_07630	COG0745	RESPONSE REGULATOR receiver
M1S19_07640	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S19_07640	COG2146	nitrite reductase [NAD(P)H] activity
M1S19_07645	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S19_07650	COG0243	molybdopterin cofactor binding
M1S19_07665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S19_07680	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S19_07680	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S19_07685	COG0303	'Molybdopterin
M1S19_07695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S19_07700	COG0697	spore germination
M1S19_07720	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S19_07725	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S19_07790	COG2204	response regulator
M1S19_07795	COG3852	Histidine kinase
M1S19_07815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S19_07820	COG0575	Belongs to the CDS family
M1S19_07855	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S19_07870	COG2137	regulation of response to DNA damage stimulus
M1S19_07880	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S19_07885	COG1011	Hydrolase
M1S19_07910	COG1522	sequence-specific DNA binding
M1S19_07920	COG1113	amino acid transport
M1S19_07940	COG0659	secondary active sulfate transmembrane transporter activity
M1S19_07945	COG2135	peptidase activity
M1S19_07960	COG3300	MHYT domain
M1S19_07960	COG5001	Diguanylate cyclase
M1S19_07990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S19_07990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S19_07990	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S19_07995	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S19_08000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S19_08000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S19_08030	COG0024	Methionine aminopeptidase
M1S19_08035	COG0583	DNA-binding transcription factor activity
M1S19_08045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S19_08050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S19_08055	COG0517	IMP dehydrogenase activity
M1S19_08055	COG0516	GMP reductase activity
M1S19_08080	COG0552	protein localization to endoplasmic reticulum
M1S19_08090	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S19_08105	COG4890	Cyd operon protein YbgT
M1S19_08110	COG1294	oxidase, subunit
M1S19_08125	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S19_08135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S19_08140	COG4774	siderophore transport
M1S19_08155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S19_08160	COG0569	domain protein
M1S19_08165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S19_08195	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S19_08200	COG0542	response to heat
M1S19_08225	COG1902	pentaerythritol trinitrate reductase activity
M1S19_08225	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S19_08270	COG2323	membrane
M1S19_08275	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S19_08285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S19_08290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S19_08295	COG0183	Belongs to the thiolase family
M1S19_08300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S19_08305	COG0596	Alpha beta hydrolase
M1S19_08310	COG2271	Major facilitator Superfamily
M1S19_08315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S19_08320	COG3485	protocatechuate 3,4-dioxygenase
M1S19_08325	COG3485	protocatechuate 3,4-dioxygenase
M1S19_08330	COG0710	3-dehydroquinate dehydratase activity
M1S19_08335	COG3420	alginic acid biosynthetic process
M1S19_08340	COG3659	wide pore channel activity
M1S19_08345	COG4993	Dehydrogenase
M1S19_08355	COG2391	methyltransferase activity
M1S19_08370	COG1414	Transcriptional regulator
M1S19_08375	COG0583	DNA-binding transcription factor activity
M1S19_08380	COG1960	acyl-CoA dehydrogenase activity
M1S19_08405	COG2814	Major facilitator Superfamily
M1S19_08415	COG0154	amidase activity
M1S19_08435	COG4638	Rieske (2fe-2S)
M1S19_08445	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_08455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S19_08465	COG3733	amine oxidase
M1S19_08475	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_08485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S19_08490	COG0183	Belongs to the thiolase family
M1S19_08495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S19_08500	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S19_08510	COG4829	muconolactone delta-isomerase
M1S19_08515	COG4948	Mandelate Racemase Muconate Lactonizing
M1S19_08520	COG0583	DNA-binding transcription factor activity
M1S19_08530	COG2186	Transcriptional regulator
M1S19_08550	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_08555	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_08575	COG1960	acyl-CoA dehydrogenase activity
M1S19_08580	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_08585	COG3829	transcription factor binding
M1S19_08595	COG3162	membrane
M1S19_08610	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_08625	COG0753	catalase activity
M1S19_08645	COG1846	Transcriptional regulator
M1S19_08650	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S19_08650	COG1902	pentaerythritol trinitrate reductase activity
M1S19_08660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S19_08690	COG1309	transcriptional regulator
M1S19_08700	COG1335	isochorismatase
M1S19_08705	COG0583	DNA-binding transcription factor activity
M1S19_08715	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S19_08715	COG0475	glutathione-regulated potassium exporter activity
M1S19_08725	COG1473	amidohydrolase
M1S19_08735	COG2831	hemolysin activation secretion protein
M1S19_08740	COG3210	domain, Protein
M1S19_08770	COG2188	Transcriptional regulator
M1S19_08785	COG0583	DNA-binding transcription factor activity
M1S19_08815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S19_08845	COG1566	PFAM secretion protein HlyD family protein
M1S19_08860	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_08865	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_08870	COG0129	dihydroxy-acid dehydratase activity
M1S19_08880	COG0583	DNA-binding transcription factor activity
M1S19_08885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S19_08895	COG2084	Dehydrogenase
M1S19_08900	COG2207	Transcriptional regulator
M1S19_08915	COG1064	alcohol dehydrogenase
M1S19_08925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S19_08930	COG1120	ATPase activity
M1S19_08950	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S19_09070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S19_09120	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_09135	COG2207	Transcriptional regulator
M1S19_09145	COG2205	protein histidine kinase activity
M1S19_09150	COG0745	RESPONSE REGULATOR receiver
M1S19_09155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S19_09160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S19_09165	COG1538	Outer membrane efflux protein
M1S19_09175	COG2072	flavoprotein involved in K transport
M1S19_09195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S19_09215	COG3539	Fimbrial protein
M1S19_09245	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S19_09255	COG0753	catalase activity
M1S19_09270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S19_09335	COG3433	isochorismatase activity
M1S19_09335	COG1535	isochorismatase
M1S19_09340	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_09345	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S19_09350	COG4149	molybdate abc transporter
M1S19_09355	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S19_09365	COG4638	Rieske (2fe-2S)
M1S19_09370	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S19_09375	COG0543	2 iron, 2 sulfur cluster binding
M1S19_09375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S19_09400	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_09415	COG2207	Transcriptional regulator
M1S19_09425	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_09430	COG2610	gluconate transmembrane transporter activity
M1S19_09440	COG0583	DNA-binding transcription factor activity
M1S19_09450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S19_09455	COG2031	fatty acid transporter
M1S19_09460	COG0183	Belongs to the thiolase family
M1S19_09465	COG0583	DNA-binding transcription factor activity
M1S19_09470	COG0583	DNA-binding transcription factor activity
M1S19_09485	COG1027	Aspartate ammonia-lyase
M1S19_09495	COG0477	Major facilitator Superfamily
M1S19_09515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S19_09520	COG4521	taurine ABC transporter
M1S19_09535	COG2188	Transcriptional regulator
M1S19_09545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S19_09550	COG1733	regulation of RNA biosynthetic process
M1S19_09555	COG2207	Transcriptional regulator
M1S19_09555	COG3708	Transcriptional regulator
M1S19_09570	COG0730	response to heat
M1S19_09585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S19_09585	COG3453	Protein conserved in bacteria
M1S19_09595	COG3781	membrane
M1S19_09600	COG1063	alcohol dehydrogenase
M1S19_09610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S19_09615	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S19_09620	COG0022	dehydrogenase e1 component
M1S19_09625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S19_09630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S19_09645	COG3706	GGDEF domain
M1S19_09660	COG0133	tryptophan synthase activity
M1S19_09670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S19_09705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S19_09730	COG2226	methyltransferase
M1S19_09785	COG0842	Transport permease protein
M1S19_09790	COG0842	Transport permease protein
M1S19_09795	COG1131	(ABC) transporter
M1S19_09810	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S19_09815	COG4773	Receptor
M1S19_09835	COG0730	response to heat
M1S19_09840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S19_09860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S19_09875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S19_09915	COG4264	IucA IucC family
M1S19_09920	COG4264	IucA IucC family
M1S19_09940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S19_09955	COG1960	acyl-CoA dehydrogenase activity
M1S19_09960	COG1960	acyl-CoA dehydrogenase activity
M1S19_09965	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S19_09970	COG2207	Transcriptional regulator
M1S19_09975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S19_09980	COG0776	regulation of translation
M1S19_10005	COG0822	iron-sulfur transferase activity
M1S19_10010	COG0316	Belongs to the HesB IscA family
M1S19_10040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S19_10060	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S19_10065	COG0702	epimerase
M1S19_10100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S19_10110	COG0339	signal peptide processing
M1S19_10160	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S19_10165	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S19_10195	COG0776	regulation of translation
M1S19_10260	COG0084	hydrolase, TatD family'
M1S19_10280	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S19_10285	COG1132	(ABC) transporter
M1S19_10295	COG0811	peptide transport
M1S19_10300	COG1475	DNA binding
M1S19_10305	COG1192	Involved in chromosome partitioning
M1S19_10315	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S19_10330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S19_10335	COG0191	fructose-bisphosphate aldolase activity
M1S19_10355	COG0424	maF-like protein
M1S19_10360	COG2850	peptidyl-arginine hydroxylation
M1S19_10370	COG0640	Transcriptional regulator
M1S19_10380	COG3619	membrane
M1S19_10385	COG3122	Protein conserved in bacteria
M1S19_10390	COG1132	(ABC) transporter
M1S19_10410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S19_10415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S19_10425	COG0506	proline dehydrogenase activity
M1S19_10425	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S19_10425	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S19_10430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S19_10445	COG3698	Phosphodiester glycosidase
M1S19_10455	COG2353	YceI-like domain
M1S19_10465	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S19_10510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S19_10510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S19_10535	COG3539	Fimbrial protein
M1S19_10540	COG3121	Chaperone
M1S19_10565	COG0697	spore germination
M1S19_10575	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S19_10585	COG0583	DNA-binding transcription factor activity
M1S19_10605	COG1309	transcriptional regulator
M1S19_10620	COG1522	sequence-specific DNA binding
M1S19_10635	COG1126	abc transporter atp-binding protein
M1S19_10640	COG0765	amino acid transport
M1S19_10645	COG0765	amino acid transport
M1S19_10675	COG1464	Belongs to the NlpA lipoprotein family
M1S19_10695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S19_10700	COG2011	ABC-type metal ion transport system permease component
M1S19_10705	COG0012	GTP binding
M1S19_10730	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S19_10770	COG0386	Belongs to the glutathione peroxidase family
M1S19_10780	COG0436	Aminotransferase
M1S19_10820	COG3634	alkyl hydroperoxide reductase activity
M1S19_10835	COG0583	DNA-binding transcription factor activity
M1S19_10840	COG0798	PFAM Bile acid sodium symporter
M1S19_10845	COG0640	Transcriptional regulator
M1S19_10860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S19_10870	COG0583	DNA-binding transcription factor activity
M1S19_10880	COG1953	Uracil, thiamine, allantoin
M1S19_10890	COG2175	clavaminate synthase activity
M1S19_10895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S19_10900	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S19_10905	COG4521	taurine ABC transporter
M1S19_10915	COG0477	Major facilitator Superfamily
M1S19_10935	COG1271	oxidase subunit
M1S19_10940	COG1294	oxidase, subunit
M1S19_10950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S19_10970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S19_10990	COG3052	prosthetic group binding
M1S19_10995	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S19_11005	COG2814	Major facilitator Superfamily
M1S19_11025	COG1346	cytolysis
M1S19_11035	COG0583	DNA-binding transcription factor activity
M1S19_11040	COG0625	glutathione transferase activity
M1S19_11045	COG0625	glutathione transferase activity
M1S19_11050	COG0583	DNA-binding transcription factor activity
M1S19_11065	COG1045	serine acetyltransferase
M1S19_11070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S19_11075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S19_11085	COG1280	lysine exporter protein (LysE YggA)
M1S19_11100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S19_11105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S19_11110	COG1126	abc transporter atp-binding protein
M1S19_11115	COG0765	amino acid transport
M1S19_11120	COG0765	amino acid transport
M1S19_11140	COG2205	protein histidine kinase activity
M1S19_11140	COG0784	Response regulator, receiver
M1S19_11160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S19_11180	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_11230	COG0583	DNA-binding transcription factor activity
M1S19_11250	COG0318	PFAM AMP-dependent synthetase and ligase
M1S19_11255	COG1309	transcriptional regulator
M1S19_11260	COG1960	acyl-CoA dehydrogenase activity
M1S19_11265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S19_11270	COG1024	Enoyl-CoA hydratase
M1S19_11275	COG4770	biotin carboxylase activity
M1S19_11285	COG0583	DNA-binding transcription factor activity
M1S19_11300	COG1960	acyl-CoA dehydrogenase activity
M1S19_11310	COG2814	Major facilitator Superfamily
M1S19_11320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S19_11325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S19_11330	COG2814	Major facilitator Superfamily
M1S19_11335	COG1960	acyl-CoA dehydrogenase activity
M1S19_11340	COG1024	Enoyl-CoA hydratase
M1S19_11345	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_11350	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S19_11355	COG0183	Belongs to the thiolase family
M1S19_11365	COG2814	Major facilitator Superfamily
M1S19_11375	COG1024	Enoyl-CoA hydratase
M1S19_11390	COG1960	acyl-CoA dehydrogenase activity
M1S19_11395	COG2814	Major facilitator Superfamily
M1S19_11400	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S19_11405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S19_11420	COG3842	ATPase activity
M1S19_11425	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S19_11435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S19_11440	COG1414	Transcriptional regulator
M1S19_11450	COG0583	DNA-binding transcription factor activity
M1S19_11455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S19_11460	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_11470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S19_11480	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_11485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S19_11490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S19_11495	COG2267	carboxylic ester hydrolase activity
M1S19_11515	COG3038	cytochrome b561
M1S19_11520	COG0753	catalase activity
M1S19_11555	COG2050	protein possibly involved in aromatic compounds catabolism
M1S19_11565	COG3327	negative regulation of DNA-templated transcription, initiation
M1S19_11570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S19_11575	COG0183	Belongs to the thiolase family
M1S19_11580	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S19_11585	COG1024	Enoyl-CoA hydratase
M1S19_11590	COG1024	Enoyl-CoA hydratase
M1S19_11595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S19_11600	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S19_11605	COG3396	Phenylacetate-CoA oxygenase
M1S19_11610	COG3460	Phenylacetate-CoA oxygenase
M1S19_11615	COG3396	Phenylacetate-CoA oxygenase
M1S19_11620	COG2030	dehydratase
M1S19_11620	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_11625	COG1760	l-serine dehydratase
M1S19_11630	COG0531	amino acid
M1S19_11635	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_11650	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S19_11660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S19_11680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S19_11690	COG0789	Transcriptional regulator
M1S19_11705	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S19_11720	COG2807	transmembrane transport
M1S19_11725	COG0590	tRNA wobble adenosine to inosine editing
M1S19_11845	COG1116	anion transmembrane transporter activity
M1S19_11850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S19_11860	COG0864	Transcriptional regulator
M1S19_11880	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S19_11885	COG0439	Biotin carboxylase
M1S19_11900	COG1063	alcohol dehydrogenase
M1S19_11910	COG1309	transcriptional regulator
M1S19_11930	COG0038	chloride channel
M1S19_11935	COG4770	biotin carboxylase activity
M1S19_11955	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S19_11960	COG0583	DNA-binding transcription factor activity
M1S19_12010	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S19_12030	COG2814	Major facilitator Superfamily
M1S19_12045	COG1560	Kdo2-lipid A biosynthetic process
M1S19_12055	COG5006	permease, DMT superfamily
M1S19_12060	COG1522	sequence-specific DNA binding
M1S19_12075	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S19_12085	COG4122	O-methyltransferase activity
M1S19_12115	COG1538	Outer membrane efflux protein
M1S19_12120	COG1137	ATPase activity
M1S19_12125	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S19_12135	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S19_12140	COG0517	IMP dehydrogenase activity
M1S19_12140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S19_12185	COG2814	Major facilitator Superfamily
M1S19_12220	COG1278	Cold shock
M1S19_12225	COG1280	lysine exporter protein (LysE YggA)
M1S19_12255	COG1570	exodeoxyribonuclease VII activity
M1S19_12305	COG0583	DNA-binding transcription factor activity
M1S19_12315	COG4638	Rieske (2fe-2S)
M1S19_12320	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S19_12325	COG0543	2 iron, 2 sulfur cluster binding
M1S19_12325	COG0633	Ferredoxin
M1S19_12330	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_12335	COG3135	benzoate transporter
M1S19_12340	COG2814	Major facilitator Superfamily
M1S19_12355	COG1643	Atp-dependent helicase
M1S19_12360	COG0450	alkyl hydroperoxide reductase
M1S19_12370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S19_12380	COG3634	alkyl hydroperoxide reductase activity
M1S19_12400	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S19_12405	COG0625	glutathione transferase activity
M1S19_12415	COG2885	chlorophyll binding
M1S19_12450	COG0542	response to heat
M1S19_12465	COG1765	OsmC-like protein
M1S19_12485	COG0667	Aldo Keto reductase
M1S19_12500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S19_12510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S19_12520	COG0527	aspartate kinase activity
M1S19_12530	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S19_12540	COG3038	cytochrome b561
M1S19_12545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S19_12550	COG2252	PERMEase
M1S19_12560	COG2072	flavoprotein involved in K transport
M1S19_12575	COG1741	Belongs to the pirin family
M1S19_12580	COG1309	transcriptional regulator
M1S19_12590	COG0300	oxidoreductase activity
M1S19_12700	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S19_12745	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_12765	COG0531	amino acid
M1S19_12775	COG1113	amino acid transport
M1S19_12815	COG3209	COG3209 Rhs family protein
M1S19_12845	COG4269	membrane
M1S19_12860	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S19_12860	COG1902	pentaerythritol trinitrate reductase activity
M1S19_12870	COG2203	Gaf domain
M1S19_12870	COG3706	GGDEF domain
M1S19_12870	COG4251	negative regulation of phosphorylation
M1S19_12870	COG5001	Diguanylate cyclase
M1S19_12880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S19_12900	COG4172	Belongs to the ABC transporter superfamily
M1S19_12905	COG4239	(ABC) transporter, permease
M1S19_12910	COG4174	ABC transporter (Permease)
M1S19_12920	COG0741	lytic transglycosylase activity
M1S19_12920	COG1388	LysM domain
M1S19_12920	COG0741	lytic transglycosylase activity
M1S19_12920	COG1388	LysM domain
M1S19_12925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S19_12965	COG0583	DNA-binding transcription factor activity
M1S19_12970	COG1279	arginine transmembrane transporter activity
M1S19_12990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S19_12995	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S19_13000	COG0006	proline dipeptidase activity
M1S19_13085	COG1196	nuclear chromosome segregation
M1S19_13085	COG0739	heme binding
M1S19_13085	COG0741	lytic transglycosylase activity
M1S19_13145	COG4695	Portal protein
M1S19_13245	COG0305	Participates in initiation and elongation during chromosome replication
M1S19_13265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S19_13320	COG2194	sulfuric ester hydrolase activity
M1S19_13365	COG0739	heme binding
M1S19_13690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S19_13715	COG3384	dioxygenase
M1S19_13730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S19_13735	COG2878	Part of a membrane complex involved in electron transport
M1S19_13740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S19_13765	COG0768	penicillin binding
M1S19_13770	COG0742	ribosomal rna small subunit methyltransferase
M1S19_13785	COG0830	nickel cation binding
M1S19_13795	COG0804	urea catabolic process
M1S19_13835	COG1253	flavin adenine dinucleotide binding
M1S19_13840	COG2851	Citrate transporter
M1S19_13890	COG1773	rubredoxin
M1S19_13895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S19_13905	COG0583	DNA-binding transcription factor activity
M1S19_13930	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S19_13935	COG4181	ATPase activity
M1S19_13980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S19_14000	COG0306	phosphate transporter
M1S19_14010	COG3958	Transketolase
M1S19_14015	COG3959	Transketolase, thiamine diphosphate binding domain
M1S19_14020	COG2271	Major facilitator Superfamily
M1S19_14025	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_14030	COG0583	DNA-binding transcription factor activity
M1S19_14045	COG2223	nitrite transmembrane transporter activity
M1S19_14050	COG2207	Transcriptional regulator
M1S19_14055	COG2066	Belongs to the glutaminase family
M1S19_14060	COG0242	peptide deformylase activity
M1S19_14065	COG0477	Major facilitator Superfamily
M1S19_14075	COG0028	Belongs to the TPP enzyme family
M1S19_14090	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_14095	COG2267	carboxylic ester hydrolase activity
M1S19_14105	COG2271	Major facilitator Superfamily
M1S19_14110	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S19_14120	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_14140	COG1414	Transcriptional regulator
M1S19_14155	COG1024	Enoyl-CoA hydratase
M1S19_14165	COG1215	transferase activity, transferring glycosyl groups
M1S19_14170	COG0726	polysaccharide deacetylase
M1S19_14170	COG1649	PFAM Uncharacterised BCR, COG1649
M1S19_14180	COG4681	YaeQ
M1S19_14190	COG0523	cobalamin synthesis protein
M1S19_14200	COG1607	acyl-coa hydrolase
M1S19_14210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S19_14215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S19_14220	COG1309	transcriptional regulator
M1S19_14245	COG2040	homocysteine
M1S19_14250	COG0531	amino acid
M1S19_14305	COG1595	DNA-templated transcription, initiation
M1S19_14315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S19_14320	COG0477	Major facilitator Superfamily
M1S19_14340	COG0084	hydrolase, TatD family'
M1S19_14375	COG0629	single-stranded DNA binding
M1S19_14430	COG0582	viral genome integration into host DNA
M1S19_14460	COG1061	Type III restriction enzyme res subunit
M1S19_14470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S19_14475	COG1192	Involved in chromosome partitioning
M1S19_14490	COG1061	Type III restriction enzyme res subunit
M1S19_14510	COG1061	Type III restriction enzyme res subunit
M1S19_14515	COG1061	Type III restriction enzyme res subunit
M1S19_14525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S19_14530	COG1192	Involved in chromosome partitioning
M1S19_14540	COG1061	Type III restriction enzyme res subunit
M1S19_14560	COG1061	Type III restriction enzyme res subunit
M1S19_14565	COG1061	Type III restriction enzyme res subunit
M1S19_14580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S19_14585	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S19_14590	COG1192	Involved in chromosome partitioning
M1S19_14600	COG1061	Type III restriction enzyme res subunit
M1S19_14620	COG1061	Type III restriction enzyme res subunit
M1S19_14630	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S19_14635	COG1192	Involved in chromosome partitioning
M1S19_14645	COG1061	Type III restriction enzyme res subunit
M1S19_14735	COG0592	DNA-directed DNA polymerase activity
M1S19_14775	COG2026	Addiction module toxin, RelE StbE family
M1S19_14925	COG3755	Protein conserved in bacteria
M1S19_14970	COG1484	DNA-dependent DNA replication
M1S19_15060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S19_15130	COG0405	Gamma-glutamyltransferase
M1S19_15135	COG2814	Major facilitator Superfamily
M1S19_15145	COG2050	protein possibly involved in aromatic compounds catabolism
M1S19_15160	COG1090	epimerase
M1S19_15180	COG0420	3'-5' exonuclease activity
M1S19_15205	COG0735	belongs to the Fur family
M1S19_15210	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S19_15230	COG0121	glutamine amidotransferase
M1S19_15245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S19_15255	COG0210	DNA helicase
M1S19_15260	COG2885	chlorophyll binding
M1S19_15265	COG0204	Acyl-transferase
M1S19_15280	COG2894	cell division
M1S19_15305	COG1280	lysine exporter protein (LysE YggA)
M1S19_15310	COG1674	ftsk spoiiie
M1S19_15310	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S19_15315	COG0492	ferredoxin-NADP+ reductase activity
M1S19_15320	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S19_15330	COG0456	acetyltransferase
M1S19_15375	COG1981	membrane
M1S19_15390	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S19_15390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S19_15410	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_15420	COG0657	acetylesterase activity
M1S19_15430	COG0473	3-isopropylmalate dehydrogenase activity
M1S19_15435	COG0583	DNA-binding transcription factor activity
M1S19_15455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S19_15480	COG0564	pseudouridine synthase activity
M1S19_15490	COG0358	DNA primase activity
M1S19_15505	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S19_15535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S19_15565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S19_15575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S19_15575	COG0352	thiamine-phosphate diphosphorylase activity
M1S19_15575	COG0351	phosphomethylpyrimidine kinase
M1S19_15580	COG1652	LysM domain
M1S19_15605	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S19_15610	COG3101	peptidyl-lysine hydroxylation
M1S19_15615	COG0009	L-threonylcarbamoyladenylate synthase
M1S19_15620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S19_15625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S19_15640	COG4106	trans-aconitate 2-methyltransferase activity
M1S19_15655	COG0596	Alpha beta hydrolase
M1S19_15655	COG2226	methyltransferase
M1S19_15655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S19_15660	COG1877	trehalose-phosphatase activity
M1S19_15665	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S19_15670	COG2223	nitrite transmembrane transporter activity
M1S19_15690	COG1196	nuclear chromosome segregation
M1S19_15700	COG0730	response to heat
M1S19_15715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S19_15725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S19_15775	COG0489	protein tyrosine kinase activity
M1S19_15785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S19_15785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S19_15815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S19_15820	COG2081	HI0933 family
M1S19_15830	COG0668	transmembrane transport
M1S19_15850	COG0583	DNA-binding transcription factor activity
M1S19_15870	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S19_15875	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S19_15905	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S19_15945	COG0745	RESPONSE REGULATOR receiver
M1S19_15965	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S19_15975	COG2205	protein histidine kinase activity
M1S19_16045	COG4993	Dehydrogenase
M1S19_16070	COG0384	phenazine biosynthesis protein PhzF
M1S19_16095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S19_16110	COG0583	DNA-binding transcription factor activity
M1S19_16140	COG0583	DNA-binding transcription factor activity
M1S19_16155	COG0583	DNA-binding transcription factor activity
M1S19_16160	COG1053	succinate dehydrogenase
M1S19_16170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S19_16175	COG2814	Major facilitator Superfamily
M1S19_16180	COG1960	acyl-CoA dehydrogenase activity
M1S19_16185	COG0583	DNA-binding transcription factor activity
M1S19_16190	COG1063	alcohol dehydrogenase
M1S19_16220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S19_16225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S19_16230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S19_16245	COG3667	copper resistance
M1S19_16250	COG2132	Multicopper oxidase
M1S19_16260	COG0561	phosphatase activity
M1S19_16265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S19_16290	COG1214	PFAM Peptidase M22, glycoprotease
M1S19_16340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S19_16350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S19_16355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S19_16360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S19_16420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S19_16430	COG1846	Transcriptional regulator
M1S19_16435	COG1764	response to oxidative stress
M1S19_16475	COG0037	tRNA processing
M1S19_16485	COG0248	Ppx GppA phosphatase
M1S19_16515	COG0072	phenylalanine-tRNA ligase activity
M1S19_16560	COG1238	metal cluster binding
M1S19_16565	COG0625	glutathione transferase activity
M1S19_16580	COG0318	PFAM AMP-dependent synthetase and ligase
M1S19_16585	COG3028	Belongs to the UPF0307 family
M1S19_16590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S19_16610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S19_16615	COG0617	tRNA 3'-terminal CCA addition
M1S19_16620	COG1555	photosystem II stabilization
M1S19_16625	COG3956	TIGRFAM MazG family protein
M1S19_16635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S19_16655	COG5002	protein histidine kinase activity
M1S19_16655	COG2205	protein histidine kinase activity
M1S19_16655	COG0784	Response regulator, receiver
M1S19_16660	COG1024	Enoyl-CoA hydratase
M1S19_16665	COG2084	Dehydrogenase
M1S19_16670	COG3622	Belongs to the hyi family
M1S19_16700	COG0697	spore germination
M1S19_16710	COG2814	Major facilitator Superfamily
M1S19_16715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S19_16725	COG0583	DNA-binding transcription factor activity
M1S19_16735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S19_16750	COG0084	hydrolase, TatD family'
M1S19_16765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S19_16795	COG0440	acetolactate synthase activity
M1S19_16800	COG0028	Belongs to the TPP enzyme family
M1S19_16825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S19_16830	COG1136	(ABC) transporter
M1S19_16830	COG0577	efflux transmembrane transporter activity
M1S19_16835	COG1538	Outer membrane efflux protein
M1S19_16850	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S19_16855	COG1162	GTPase activity
M1S19_16865	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S19_16885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S19_16890	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_16930	COG2986	histidine ammonia-lyase
M1S19_16945	COG0318	PFAM AMP-dependent synthetase and ligase
M1S19_16955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S19_17000	COG1426	Protein conserved in bacteria
M1S19_17035	COG0793	Belongs to the peptidase S41A family
M1S19_17050	COG2267	carboxylic ester hydrolase activity
M1S19_17060	COG1012	belongs to the aldehyde dehydrogenase family
M1S19_17065	COG3265	gluconokinase activity
M1S19_17075	COG0800	Aldolase
M1S19_17085	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S19_17090	COG0280	phosphate acetyltransferase
M1S19_17090	COG0857	belongs to the CobB CobQ family
M1S19_17095	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S19_17095	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S19_17115	COG0740	serine-type endopeptidase activity
M1S19_17125	COG4774	siderophore transport
M1S19_17135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S19_17145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S19_17145	COG2813	Specifically methylates the guanine in position
M1S19_17245	COG0788	formyltetrahydrofolate deformylase activity
M1S19_17270	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S19_17270	COG4651	solute:proton antiporter activity
M1S19_17290	COG0724	RNA recognition motif
M1S19_17295	COG0210	DNA helicase
M1S19_17320	COG1733	regulation of RNA biosynthetic process
M1S19_17330	COG2900	Belongs to the SlyX family
M1S19_17335	COG0488	(ABC) transporter
M1S19_17340	COG1280	lysine exporter protein (LysE YggA)
M1S19_17345	COG1560	Kdo2-lipid A biosynthetic process
M1S19_17355	COG1301	dicarboxylic acid transport
M1S19_17410	COG0473	3-isopropylmalate dehydrogenase activity
M1S19_17475	COG0583	DNA-binding transcription factor activity
M1S19_17485	COG0625	glutathione transferase activity
M1S19_17490	COG2378	regulation of single-species biofilm formation
M1S19_17495	COG0546	phosphoglycolate phosphatase activity
M1S19_17505	COG1530	ribonuclease E activity
M1S19_17510	COG0318	PFAM AMP-dependent synthetase and ligase
M1S19_17525	COG0583	DNA-binding transcription factor activity
M1S19_17530	COG4221	oxidoreductase activity
M1S19_17535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S19_17545	COG0534	Mate efflux family protein
M1S19_17560	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S19_17600	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S19_17605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S19_17620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S19_17630	COG0644	oxidoreductase
M1S19_17630	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S19_17635	COG0425	Belongs to the sulfur carrier protein TusA family
M1S19_17640	COG4535	Mg2 and Co2 transporter CorC
M1S19_17650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S19_17670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S19_17675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S19_17675	COG0475	glutathione-regulated potassium exporter activity
M1S19_17680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S19_17690	COG0484	heat shock protein binding
M1S19_17695	COG0789	Transcriptional regulator
M1S19_17700	COG0598	Magnesium transport protein CorA
M1S19_17715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S19_17720	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S19_17725	COG1074	ATP-dependent DNA helicase activity
M1S19_17730	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S19_17750	COG2226	methyltransferase
M1S19_17765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S19_17770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S19_17785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S19_17785	COG2111	Na H antiporter
M1S19_17790	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S19_17795	COG0651	ATP synthesis coupled electron transport
M1S19_17800	COG1863	multisubunit Na H antiporter MnhE subunit
M1S19_17805	COG2212	antiporter activity
M1S19_17810	COG1320	monovalent cation:proton antiporter activity
M1S19_17825	COG0195	Participates in both transcription termination and antitermination
M1S19_17875	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S19_17880	COG0237	dephospho-CoA kinase activity
M1S19_17890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S19_17905	COG0497	DNA recombination
M1S19_17915	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S19_17945	COG2169	Transcriptional regulator
M1S19_17945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S19_17950	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S19_18015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S19_18030	COG0326	Molecular chaperone. Has ATPase activity
M1S19_18045	COG2056	Na+-H+ antiporter family
M1S19_18050	COG0596	Alpha beta hydrolase
M1S19_18145	COG0546	phosphoglycolate phosphatase activity
M1S19_18150	COG1716	ATPase activity
M1S19_18195	COG0181	hydroxymethylbilane synthase activity
M1S19_18205	COG3275	phosphorelay sensor kinase activity
M1S19_18225	COG1538	Outer membrane efflux protein
M1S19_18230	COG0697	spore germination
M1S19_18255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S19_18260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S19_18265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S19_18270	COG0772	Belongs to the SEDS family
M1S19_18295	COG4974	Belongs to the 'phage' integrase family
M1S19_18300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S19_18310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S19_18320	COG2197	response regulator
M1S19_18335	COG0793	Belongs to the peptidase S41A family
M1S19_18340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S19_18345	COG0795	lipopolysaccharide-transporting ATPase activity
M1S19_18385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S19_18385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S19_18395	COG0004	ammonium transporteR
M1S19_18400	COG0347	Belongs to the P(II) protein family
M1S19_18460	COG0659	secondary active sulfate transmembrane transporter activity
M1S19_18465	COG0589	response to stress
M1S19_18495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S19_18540	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S19_18570	COG0659	secondary active sulfate transmembrane transporter activity
M1S19_18575	COG0589	response to stress
M1S19_18610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S19_18620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S19_18640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S19_18655	COG0318	PFAM AMP-dependent synthetase and ligase
M1S19_18665	COG0477	Major facilitator Superfamily
M1S19_18670	COG2860	membrane
M1S19_18680	COG1253	flavin adenine dinucleotide binding
M1S19_18700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S19_18740	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S19_18750	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S19_18820	COG0758	DNA mediated transformation
M1S19_18830	COG0697	spore germination
M1S19_18835	COG1309	transcriptional regulator
M1S19_18850	COG0386	Belongs to the glutathione peroxidase family
M1S19_18915	COG1121	(ABC) transporter
M1S19_18920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S19_18925	COG1280	lysine exporter protein (LysE YggA)
M1S19_18930	COG2837	iron assimilation
M1S19_18940	COG0281	malic enzyme
M1S19_18985	COG0519	Catalyzes the synthesis of GMP from XMP
M1S19_18985	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S19_18990	COG4399	Belongs to the UPF0754 family
M1S19_18995	COG2259	Doxx family
M1S19_19000	COG0586	Pfam SNARE associated Golgi protein
M1S19_19015	COG1192	Involved in chromosome partitioning
M1S19_19025	COG0271	Belongs to the BolA IbaG family
M1S19_19045	COG2267	carboxylic ester hydrolase activity
M1S19_19065	COG3321	synthase
M1S19_19065	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S19_19065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S19_19065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S19_19070	COG1960	acyl-CoA dehydrogenase activity
M1S19_19080	COG2197	response regulator
M1S19_19090	COG3916	Acyl-homoserine-lactone synthase
M1S19_19095	COG0477	Major facilitator Superfamily
M1S19_19100	COG1024	Enoyl-CoA hydratase
M1S19_19105	COG1024	Enoyl-CoA hydratase
M1S19_19110	COG1960	acyl-CoA dehydrogenase activity
M1S19_19115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S19_19135	COG1113	amino acid transport
M1S19_19140	COG1113	amino acid transport
M1S19_19145	COG0251	oxidation-reduction process
M1S19_19185	COG0564	pseudouridine synthase activity
M1S19_19245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S19_19260	COG1802	Transcriptional regulator
M1S19_19270	COG1448	Aminotransferase
M1S19_19275	COG0277	FAD linked oxidase domain protein
M1S19_19285	COG2186	Transcriptional regulator
M1S19_19295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S19_19300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S19_19315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S19_19320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S19_19325	COG1216	Glycosyl transferase, family 2
M1S19_19355	COG2089	acid synthase
M1S19_19370	COG1083	cytidylyl-transferase
M1S19_19375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S19_19380	COG1086	Polysaccharide biosynthesis protein
M1S19_19385	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S19_19390	COG1596	polysaccharide export
M1S19_19415	COG0728	peptidoglycan biosynthetic process
M1S19_19420	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S19_19480	COG0546	phosphoglycolate phosphatase activity
M1S19_19485	COG1028	Short-chain dehydrogenase reductase Sdr
M1S19_19505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S19_19510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S19_19515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S19_19520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S19_19525	COG1116	anion transmembrane transporter activity
M1S19_19530	COG1309	transcriptional regulator
M1S19_19535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S19_19545	COG0196	riboflavin kinase activity
M1S19_19550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S19_19560	COG1047	Peptidyl-prolyl cis-trans
M1S19_19600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S19_19605	COG0657	acetylesterase activity
M1S19_19625	COG0583	DNA-binding transcription factor activity
M1S19_19655	COG2951	lytic endotransglycosylase activity
M1S19_19660	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S19_19675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S19_19685	COG0671	phosphoesterase, PA-phosphatase related
M1S19_19690	COG0861	Integral membrane protein TerC family
M1S19_19700	COG0754	glutathionylspermidine amidase activity
M1S19_19710	COG0402	S-adenosylhomocysteine deaminase activity
M1S19_19725	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S19_19730	COG1230	cation diffusion facilitator family transporter
M1S19_19745	COG0706	membrane insertase activity
M1S19_19830	COG1525	nuclease
M1S19_20000	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S19_20035	COG0741	lytic transglycosylase activity
M1S19_20120	COG0484	heat shock protein binding
M1S19_20215	COG3853	Toxic anion resistance protein (TelA)