locus-tag	class	description
M1S15_00010	COG0592	DNA-directed DNA polymerase activity
M1S15_00020	COG0187	DNA topoisomerase II activity
M1S15_00030	COG0586	Pfam SNARE associated Golgi protein
M1S15_00035	COG0488	(ABC) transporter
M1S15_00060	COG0596	Alpha beta hydrolase
M1S15_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S15_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S15_00110	COG0733	neurotransmitter:sodium symporter activity
M1S15_00150	COG2233	PERMEase
M1S15_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S15_00200	COG2814	Major facilitator Superfamily
M1S15_00205	COG0656	L-ascorbic acid biosynthetic process
M1S15_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S15_00230	COG1064	alcohol dehydrogenase
M1S15_00235	COG2818	Glycosylase
M1S15_00250	COG1194	a g-specific adenine glycosylase
M1S15_00270	COG2983	Belongs to the UPF0260 family
M1S15_00275	COG2133	pyrroloquinoline quinone binding
M1S15_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S15_00285	COG2116	formate transmembrane transporter activity
M1S15_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S15_00310	COG1335	isochorismatase
M1S15_00315	COG0385	Bile acid
M1S15_00320	COG0534	Mate efflux family protein
M1S15_00325	COG1683	Conserved Protein
M1S15_00345	COG0625	glutathione transferase activity
M1S15_00355	COG1113	amino acid transport
M1S15_00365	COG0523	cobalamin synthesis protein
M1S15_00375	COG2188	Transcriptional regulator
M1S15_00405	COG0010	Belongs to the arginase family
M1S15_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S15_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S15_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S15_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S15_00540	COG0534	Mate efflux family protein
M1S15_00545	COG0436	Aminotransferase
M1S15_00550	COG2733	membrane
M1S15_00565	COG2918	glutathione biosynthetic process
M1S15_00580	COG1388	LysM domain
M1S15_00580	COG0791	NLP P60 protein
M1S15_00595	COG3150	esterase
M1S15_00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S15_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S15_00630	COG2233	PERMEase
M1S15_00635	COG2351	hydroxyisourate hydrolase activity
M1S15_00670	COG3706	GGDEF domain
M1S15_00685	COG1393	Belongs to the ArsC family
M1S15_00690	COG0708	Exodeoxyribonuclease III
M1S15_00710	COG0189	ligase activity
M1S15_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S15_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S15_00755	COG4942	peptidase
M1S15_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S15_00775	COG2119	membrane
M1S15_00780	COG4774	siderophore transport
M1S15_00785	COG0426	domain, Protein
M1S15_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S15_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S15_00830	COG1902	pentaerythritol trinitrate reductase activity
M1S15_00835	COG1519	Transferase
M1S15_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S15_00845	COG0668	transmembrane transport
M1S15_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S15_00860	COG1335	isochorismatase
M1S15_00865	COG1522	sequence-specific DNA binding
M1S15_00870	COG3328	transposase activity
M1S15_00895	COG0784	Response regulator, receiver
M1S15_00895	COG2198	Histidine kinase
M1S15_00895	COG2205	protein histidine kinase activity
M1S15_00900	COG3162	membrane
M1S15_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S15_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S15_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S15_00940	COG1309	transcriptional regulator
M1S15_00960	COG0351	phosphomethylpyrimidine kinase
M1S15_00960	COG0352	thiamine-phosphate diphosphorylase activity
M1S15_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S15_00970	COG2814	Major facilitator Superfamily
M1S15_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S15_00995	COG1113	amino acid transport
M1S15_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S15_01010	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_01020	COG1335	isochorismatase
M1S15_01050	COG2814	Major facilitator Superfamily
M1S15_01055	COG0583	DNA-binding transcription factor activity
M1S15_01075	COG0667	Aldo Keto reductase
M1S15_01110	COG1733	regulation of RNA biosynthetic process
M1S15_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S15_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S15_01195	COG2329	Antibiotic biosynthesis monooxygenase
M1S15_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S15_01255	COG0427	acetyl-CoA hydrolase
M1S15_01280	COG0659	secondary active sulfate transmembrane transporter activity
M1S15_01285	COG4221	oxidoreductase activity
M1S15_01290	COG2873	o-acetylhomoserine
M1S15_01295	COG0488	(ABC) transporter
M1S15_01380	COG0833	amino acid
M1S15_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S15_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S15_01445	COG2226	methyltransferase
M1S15_01495	COG0067	glutamate synthase
M1S15_01495	COG0070	glutamate synthase
M1S15_01495	COG0069	glutamate synthase activity
M1S15_01500	COG0493	'glutamate synthase
M1S15_01510	COG1704	LemA family
M1S15_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S15_01535	COG3307	-O-antigen
M1S15_01555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S15_01570	COG0194	GDP metabolic process
M1S15_01620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S15_01640	COG5380	lipid catabolic process
M1S15_01645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S15_01670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S15_01675	COG0277	FAD linked oxidase domain protein
M1S15_01685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S15_01690	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S15_01705	COG1289	transmembrane transporter activity
M1S15_01715	COG0628	permease
M1S15_01720	COG1192	Involved in chromosome partitioning
M1S15_01750	COG0833	amino acid
M1S15_01755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S15_01760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S15_01770	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_01810	COG0583	DNA-binding transcription factor activity
M1S15_01855	COG0517	IMP dehydrogenase activity
M1S15_01860	COG1983	PspC domain protein
M1S15_01870	COG1960	acyl-CoA dehydrogenase activity
M1S15_01885	COG0408	coproporphyrinogen oxidase activity
M1S15_01905	COG0513	Belongs to the DEAD box helicase family
M1S15_01915	COG1127	ABC transporter
M1S15_01920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S15_01930	COG2854	intermembrane phospholipid transfer
M1S15_01940	COG0598	Magnesium transport protein CorA
M1S15_01950	COG0494	nUDIX hydrolase
M1S15_01955	COG1040	competence protein
M1S15_01960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S15_01980	COG1946	Acyl-CoA thioesterase
M1S15_01985	COG1301	dicarboxylic acid transport
M1S15_02000	COG1959	2 iron, 2 sulfur cluster binding
M1S15_02005	COG1017	nitric oxide dioxygenase activity
M1S15_02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S15_02010	COG0433	COG0433 Predicted ATPase
M1S15_02015	COG0626	cystathionine gamma-synthase activity
M1S15_02170	COG1960	acyl-CoA dehydrogenase activity
M1S15_02175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S15_02205	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S15_02210	COG0339	signal peptide processing
M1S15_02215	COG0557	exoribonuclease II activity
M1S15_02260	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S15_02265	COG2169	Transcriptional regulator
M1S15_02270	COG0697	spore germination
M1S15_02275	COG1295	ribonuclease BN
M1S15_02310	COG1702	phosphate starvation-inducible protein PhoH
M1S15_02320	COG0739	heme binding
M1S15_02320	COG0741	lytic transglycosylase activity
M1S15_02320	COG1196	nuclear chromosome segregation
M1S15_02350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S15_02355	COG1183	phosphatidylcholine synthase activity
M1S15_02400	COG1960	acyl-CoA dehydrogenase activity
M1S15_02405	COG1309	transcriptional regulator
M1S15_02420	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S15_02425	COG1960	acyl-CoA dehydrogenase activity
M1S15_02445	COG2969	positive regulation of protein catabolic process
M1S15_02455	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S15_02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S15_02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S15_02495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S15_02505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S15_02510	COG1408	metallophosphoesterase
M1S15_02520	COG2199	diguanylate cyclase activity
M1S15_02580	COG1607	acyl-coa hydrolase
M1S15_02610	COG2350	Protein conserved in bacteria
M1S15_02620	COG0613	PHP domain protein
M1S15_02625	COG3781	membrane
M1S15_02635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S15_02640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S15_02650	COG1862	Preprotein translocase
M1S15_02700	COG0629	single-stranded DNA binding
M1S15_02770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S15_02900	COG4695	Portal protein
M1S15_02910	COG2205	protein histidine kinase activity
M1S15_02920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S15_02940	COG0726	polysaccharide deacetylase
M1S15_02945	COG0463	Glycosyl transferase, family 2
M1S15_02950	COG0438	transferase activity, transferring glycosyl groups
M1S15_03015	COG0625	glutathione transferase activity
M1S15_03020	COG0583	DNA-binding transcription factor activity
M1S15_03025	COG1960	acyl-CoA dehydrogenase activity
M1S15_03030	COG1960	acyl-CoA dehydrogenase activity
M1S15_03040	COG2205	protein histidine kinase activity
M1S15_03045	COG0745	RESPONSE REGULATOR receiver
M1S15_03050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S15_03070	COG2096	Adenosyltransferase
M1S15_03120	COG0285	dihydrofolate synthase activity
M1S15_03140	COG0450	alkyl hydroperoxide reductase
M1S15_03155	COG0477	Major facilitator Superfamily
M1S15_03160	COG1272	protein, Hemolysin III
M1S15_03190	COG0183	Belongs to the thiolase family
M1S15_03195	COG2207	Transcriptional regulator
M1S15_03215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S15_03235	COG0183	Belongs to the thiolase family
M1S15_03245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S15_03245	COG2885	chlorophyll binding
M1S15_03255	COG1690	Belongs to the RtcB family
M1S15_03260	COG0833	amino acid
M1S15_03270	COG2233	PERMEase
M1S15_03275	COG1217	gtp-binding protein TYPA
M1S15_03300	COG2094	Belongs to the DNA glycosylase MPG family
M1S15_03320	COG1902	pentaerythritol trinitrate reductase activity
M1S15_03335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S15_03340	COG0354	folic acid binding
M1S15_03350	COG3189	MarR family transcriptional regulator
M1S15_03355	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S15_03360	COG3422	double-strand break repair
M1S15_03400	COG0840	transmembrane signaling receptor activity
M1S15_03420	COG5510	response to toxic substance
M1S15_03430	COG2832	Protein of unknown function (DUF454)
M1S15_03435	COG1376	ErfK ybiS ycfS ynhG family protein
M1S15_03475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S15_03485	COG1289	transmembrane transporter activity
M1S15_03490	COG2814	Major facilitator Superfamily
M1S15_03510	COG1115	amino acid carrier protein
M1S15_03515	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S15_03520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S15_03525	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S15_03555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S15_03565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S15_03570	COG1077	Cell shape determining protein MreB Mrl
M1S15_03575	COG1792	Involved in formation and maintenance of cell shape
M1S15_03580	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S15_03585	COG0424	maF-like protein
M1S15_03590	COG1530	ribonuclease E activity
M1S15_03600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S15_03610	COG0560	Phosphoserine phosphatase
M1S15_03620	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S15_03645	COG2207	Transcriptional regulator
M1S15_03665	COG1113	amino acid transport
M1S15_03670	COG2828	Protein conserved in bacteria
M1S15_03675	COG0142	geranyltranstransferase activity
M1S15_03680	COG2315	Protein conserved in bacteria
M1S15_03695	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S15_03720	COG0745	RESPONSE REGULATOR receiver
M1S15_03725	COG0642	Histidine kinase
M1S15_03735	COG0004	ammonium transporteR
M1S15_03740	COG0583	DNA-binding transcription factor activity
M1S15_03760	COG0525	valine-tRNA ligase activity
M1S15_03770	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_03780	COG0393	Putative heavy-metal-binding
M1S15_03785	COG0393	Putative heavy-metal-binding
M1S15_03790	COG1538	Outer membrane efflux protein
M1S15_03800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S15_03805	COG0671	phosphoesterase, PA-phosphatase related
M1S15_03835	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S15_03850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S15_03850	COG1648	precorrin-2 dehydrogenase activity
M1S15_03855	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S15_03860	COG1733	regulation of RNA biosynthetic process
M1S15_03870	COG0531	amino acid
M1S15_03885	COG0321	lipoyl(octanoyl) transferase activity
M1S15_03890	COG2921	Belongs to the UPF0250 family
M1S15_03930	COG2009	succinate dehydrogenase
M1S15_03935	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S15_03940	COG1053	succinate dehydrogenase
M1S15_03945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S15_03970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S15_03990	COG2354	Protein conserved in bacteria
M1S15_03995	COG2321	neutral zinc metallopeptidase
M1S15_04025	COG2843	Capsule synthesis protein
M1S15_04040	COG0589	response to stress
M1S15_04060	COG0505	Belongs to the CarA family
M1S15_04085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S15_04090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S15_04140	COG0477	Major facilitator Superfamily
M1S15_04145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S15_04160	COG1597	lipid kinase activity
M1S15_04165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S15_04195	COG0584	glycerophosphoryl diester phosphodiesterase
M1S15_04215	COG0741	lytic transglycosylase activity
M1S15_04235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S15_04250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S15_04280	COG0778	Nitroreductase
M1S15_04295	COG1929	Belongs to the glycerate kinase type-1 family
M1S15_04300	COG0243	molybdopterin cofactor binding
M1S15_04305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S15_04310	COG3339	Conserved Protein
M1S15_04320	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S15_04335	COG1113	amino acid transport
M1S15_04345	COG0019	diaminopimelate decarboxylase activity
M1S15_04355	COG1280	lysine exporter protein (LysE YggA)
M1S15_04360	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S15_04390	COG0463	Glycosyl transferase, family 2
M1S15_04410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S15_04445	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S15_04450	COG1136	(ABC) transporter
M1S15_04455	COG0658	competence protein
M1S15_04455	COG2333	competence protein COMEC
M1S15_04465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S15_04465	COG0616	signal peptide processing
M1S15_04470	COG0596	Alpha beta hydrolase
M1S15_04475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S15_04485	COG0628	permease
M1S15_04520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S15_04540	COG0823	Involved in the tonB-independent uptake of proteins
M1S15_04560	COG0824	Thioesterase
M1S15_04565	COG1473	amidohydrolase
M1S15_04585	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S15_04585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S15_04590	COG2814	Major facilitator Superfamily
M1S15_04600	COG1024	Enoyl-CoA hydratase
M1S15_04605	COG1051	belongs to the nudix hydrolase family
M1S15_04605	COG1056	cytidyltransferase-related domain
M1S15_04615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S15_04630	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S15_04645	COG4625	pathogenesis
M1S15_04650	COG0583	DNA-binding transcription factor activity
M1S15_04655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S15_04660	COG4208	sulfate ABC transporter
M1S15_04665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S15_04675	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S15_04680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S15_04685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S15_04705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S15_04720	COG0681	Belongs to the peptidase S26 family
M1S15_04735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S15_04745	COG1381	Involved in DNA repair and RecF pathway recombination
M1S15_04750	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S15_04760	COG4221	oxidoreductase activity
M1S15_04790	COG0436	Aminotransferase
M1S15_04810	COG0556	nucleotide-excision repair
M1S15_04865	COG2070	2-Nitropropane dioxygenase
M1S15_04905	COG1215	transferase activity, transferring glycosyl groups
M1S15_04920	COG0415	Belongs to the DNA photolyase family
M1S15_04950	COG1187	pseudouridine synthase activity
M1S15_04975	COG0477	Major facilitator Superfamily
M1S15_04980	COG0583	DNA-binding transcription factor activity
M1S15_04985	COG1823	symporter activity
M1S15_04995	COG0612	Peptidase, M16
M1S15_05020	COG0352	thiamine-phosphate diphosphorylase activity
M1S15_05055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S15_05070	COG1309	transcriptional regulator
M1S15_05080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S15_05085	COG0076	glutamate decarboxylase activity
M1S15_05095	COG1522	sequence-specific DNA binding
M1S15_05100	COG3961	Belongs to the TPP enzyme family
M1S15_05105	COG1113	amino acid transport
M1S15_05110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S15_05115	COG0573	inorganic phosphate transmembrane transporter activity
M1S15_05125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S15_05130	COG0616	signal peptide processing
M1S15_05165	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S15_05170	COG1686	Belongs to the peptidase S11 family
M1S15_05195	COG0583	DNA-binding transcription factor activity
M1S15_05200	COG1067	ATP-dependent peptidase activity
M1S15_05245	COG1966	Carbon starvation protein
M1S15_05250	COG2879	small protein
M1S15_05285	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S15_05285	COG2508	Transcriptional regulator
M1S15_05305	COG1113	amino acid transport
M1S15_05310	COG0583	DNA-binding transcription factor activity
M1S15_05315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S15_05320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S15_05330	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_05340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S15_05345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S15_05345	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S15_05380	COG2814	Major facilitator Superfamily
M1S15_05385	COG4948	Mandelate Racemase Muconate Lactonizing
M1S15_05395	COG1309	transcriptional regulator
M1S15_05415	COG1741	Belongs to the pirin family
M1S15_05425	COG2964	Protein conserved in bacteria
M1S15_05440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S15_05445	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S15_05450	COG4605	iron ion homeostasis
M1S15_05455	COG4604	ABC transporter, ATP-binding protein
M1S15_05460	COG4607	ABC-type enterochelin transport system periplasmic component
M1S15_05465	COG4774	siderophore transport
M1S15_05475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S15_05480	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S15_05485	COG3433	isochorismatase activity
M1S15_05485	COG1535	isochorismatase
M1S15_05500	COG1132	(ABC) transporter
M1S15_05505	COG1132	(ABC) transporter
M1S15_05510	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S15_05520	COG1169	isochorismate synthase
M1S15_05535	COG3739	integral membrane protein
M1S15_05560	COG0302	gtp cyclohydrolase
M1S15_05570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S15_05600	COG0308	aminopeptidase N
M1S15_05605	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S15_05620	COG0174	glutamine synthetase
M1S15_05630	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S15_05665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S15_05670	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S15_05675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S15_05695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S15_05700	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S15_05705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S15_05720	COG1960	acyl-CoA dehydrogenase activity
M1S15_05725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S15_05730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S15_05740	COG2223	nitrite transmembrane transporter activity
M1S15_05750	COG0024	Methionine aminopeptidase
M1S15_05755	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S15_05770	COG2207	Transcriptional regulator
M1S15_05795	COG2951	lytic endotransglycosylase activity
M1S15_05800	COG0772	Belongs to the SEDS family
M1S15_05815	COG0842	Transport permease protein
M1S15_05820	COG1131	(ABC) transporter
M1S15_05865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S15_05880	COG4215	(ABC) transporter
M1S15_05885	COG4160	amino acid transport
M1S15_05890	COG4598	ABC transporter
M1S15_05900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S15_05905	COG0826	peptidase U32
M1S15_05910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S15_05925	COG1720	tRNA m6t6A37 methyltransferase activity
M1S15_05935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S15_05950	COG0642	Histidine kinase
M1S15_05960	COG0494	nUDIX hydrolase
M1S15_05970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S15_05975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S15_05980	COG3139	Protein of unknown function (DUF1315)
M1S15_05985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S15_05990	COG1301	dicarboxylic acid transport
M1S15_05995	COG1960	acyl-CoA dehydrogenase activity
M1S15_06000	COG2819	hydrolase of the alpha beta superfamily
M1S15_06010	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S15_06020	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S15_06025	COG1234	tRNA 3'-trailer cleavage
M1S15_06055	COG2363	Small membrane protein
M1S15_06080	COG0513	Belongs to the DEAD box helicase family
M1S15_06090	COG0778	Nitroreductase
M1S15_06120	COG1286	toxin biosynthetic process
M1S15_06145	COG4783	chaperone-mediated protein folding
M1S15_06150	COG1610	YqeY-like protein
M1S15_06250	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S15_06275	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S15_06280	COG0786	glutamate:sodium symporter activity
M1S15_06290	COG2186	Transcriptional regulator
M1S15_06340	COG0477	Major facilitator Superfamily
M1S15_06370	COG2985	domain, Protein
M1S15_06380	COG2995	paraquat-inducible protein a
M1S15_06440	COG1794	racemase activity, acting on amino acids and derivatives
M1S15_06505	COG0488	(ABC) transporter
M1S15_06510	COG3173	Aminoglycoside phosphotransferase
M1S15_06520	COG2433	Pfam Transposase IS66
M1S15_06560	COG1301	dicarboxylic acid transport
M1S15_06570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S15_06575	COG2011	ABC-type metal ion transport system permease component
M1S15_06580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S15_06585	COG1464	Belongs to the NlpA lipoprotein family
M1S15_06590	COG0151	Belongs to the GarS family
M1S15_06595	COG0138	bifunctional purine biosynthesis protein purh
M1S15_06600	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S15_06630	COG2308	Evidence 4 Homologs of previously reported genes of
M1S15_06640	COG1305	Transglutaminase-like
M1S15_06650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S15_06655	COG0305	Participates in initiation and elongation during chromosome replication
M1S15_06680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S15_06690	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S15_06695	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S15_06720	COG0726	polysaccharide deacetylase
M1S15_06720	COG1649	PFAM Uncharacterised BCR, COG1649
M1S15_06725	COG1215	transferase activity, transferring glycosyl groups
M1S15_06730	COG3658	cytochrome
M1S15_06740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S15_06755	COG0583	DNA-binding transcription factor activity
M1S15_06775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S15_06780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S15_06795	COG1960	acyl-CoA dehydrogenase activity
M1S15_06800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S15_06805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S15_06830	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S15_06835	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S15_06845	COG2205	protein histidine kinase activity
M1S15_06850	COG0745	RESPONSE REGULATOR receiver
M1S15_06855	COG0174	glutamine synthetase
M1S15_06875	COG0729	surface antigen
M1S15_06900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S15_06905	COG2814	Major facilitator Superfamily
M1S15_06920	COG0583	DNA-binding transcription factor activity
M1S15_06935	COG1187	pseudouridine synthase activity
M1S15_06955	COG0802	atpase or kinase
M1S15_06960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S15_06970	COG1923	regulation of RNA biosynthetic process
M1S15_06975	COG0697	spore germination
M1S15_06990	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S15_07000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S15_07005	COG0519	Catalyzes the synthesis of GMP from XMP
M1S15_07005	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S15_07010	COG4302	ethanolamine ammonia-lyase activity
M1S15_07015	COG4303	Ethanolamine ammonia lyase large subunit
M1S15_07020	COG0531	amino acid
M1S15_07040	COG1454	alcohol dehydrogenase
M1S15_07045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S15_07055	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S15_07075	COG0308	aminopeptidase N
M1S15_07085	COG4221	oxidoreductase activity
M1S15_07095	COG1605	Chorismate mutase
M1S15_07115	COG1309	transcriptional regulator
M1S15_07125	COG0668	transmembrane transport
M1S15_07165	COG4773	Receptor
M1S15_07185	COG0488	(ABC) transporter
M1S15_07190	COG0589	response to stress
M1S15_07215	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S15_07225	COG3135	benzoate transporter
M1S15_07230	COG1522	sequence-specific DNA binding
M1S15_07240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S15_07245	COG0583	DNA-binding transcription factor activity
M1S15_07255	COG0183	Belongs to the thiolase family
M1S15_07265	COG2030	dehydratase
M1S15_07270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S15_07285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S15_07295	COG0824	Thioesterase
M1S15_07300	COG1454	alcohol dehydrogenase
M1S15_07310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S15_07330	COG0069	glutamate synthase activity
M1S15_07660	COG2814	Major facilitator Superfamily
M1S15_07675	COG0511	ligase activity, forming carbon-carbon bonds
M1S15_07695	COG1116	anion transmembrane transporter activity
M1S15_07695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S15_07700	COG0745	RESPONSE REGULATOR receiver
M1S15_07710	COG2146	nitrite reductase [NAD(P)H] activity
M1S15_07710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S15_07715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S15_07720	COG0243	molybdopterin cofactor binding
M1S15_07730	COG0243	molybdopterin cofactor binding
M1S15_07735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S15_07750	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S15_07750	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S15_07755	COG0303	'Molybdopterin
M1S15_07765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S15_07770	COG0697	spore germination
M1S15_07790	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S15_07795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S15_07860	COG2204	response regulator
M1S15_07865	COG3852	Histidine kinase
M1S15_07885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S15_07890	COG0575	Belongs to the CDS family
M1S15_07925	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S15_07940	COG2137	regulation of response to DNA damage stimulus
M1S15_07950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S15_07955	COG1011	Hydrolase
M1S15_07980	COG1522	sequence-specific DNA binding
M1S15_07990	COG0833	amino acid
M1S15_08010	COG0659	secondary active sulfate transmembrane transporter activity
M1S15_08015	COG2135	peptidase activity
M1S15_08030	COG5001	Diguanylate cyclase
M1S15_08030	COG3300	MHYT domain
M1S15_08050	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S15_08050	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S15_08050	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S15_08055	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S15_08060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S15_08060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S15_08090	COG0024	Methionine aminopeptidase
M1S15_08095	COG0583	DNA-binding transcription factor activity
M1S15_08105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S15_08110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S15_08115	COG0517	IMP dehydrogenase activity
M1S15_08115	COG0516	GMP reductase activity
M1S15_08140	COG0552	protein localization to endoplasmic reticulum
M1S15_08150	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S15_08165	COG4890	Cyd operon protein YbgT
M1S15_08170	COG1294	oxidase, subunit
M1S15_08185	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S15_08195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S15_08200	COG4774	siderophore transport
M1S15_08215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S15_08220	COG0569	domain protein
M1S15_08225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S15_08255	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S15_08260	COG0542	response to heat
M1S15_08285	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S15_08285	COG1902	pentaerythritol trinitrate reductase activity
M1S15_08330	COG2323	membrane
M1S15_08335	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S15_08345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S15_08350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S15_08355	COG0183	Belongs to the thiolase family
M1S15_08360	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S15_08365	COG0596	Alpha beta hydrolase
M1S15_08370	COG2271	Major facilitator Superfamily
M1S15_08375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S15_08380	COG3485	protocatechuate 3,4-dioxygenase
M1S15_08385	COG3485	protocatechuate 3,4-dioxygenase
M1S15_08390	COG0710	3-dehydroquinate dehydratase activity
M1S15_08395	COG3420	alginic acid biosynthetic process
M1S15_08400	COG3659	wide pore channel activity
M1S15_08405	COG4993	Dehydrogenase
M1S15_08415	COG2391	methyltransferase activity
M1S15_08430	COG1414	Transcriptional regulator
M1S15_08435	COG0583	DNA-binding transcription factor activity
M1S15_08440	COG1960	acyl-CoA dehydrogenase activity
M1S15_08465	COG2814	Major facilitator Superfamily
M1S15_08475	COG0154	amidase activity
M1S15_08495	COG4638	Rieske (2fe-2S)
M1S15_08505	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_08515	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S15_08525	COG3733	amine oxidase
M1S15_08535	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_08545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S15_08550	COG0183	Belongs to the thiolase family
M1S15_08555	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S15_08560	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S15_08570	COG4829	muconolactone delta-isomerase
M1S15_08575	COG4948	Mandelate Racemase Muconate Lactonizing
M1S15_08590	COG2186	Transcriptional regulator
M1S15_08610	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_08635	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_08640	COG3829	transcription factor binding
M1S15_08650	COG3162	membrane
M1S15_08665	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_08680	COG0753	catalase activity
M1S15_08700	COG1846	Transcriptional regulator
M1S15_08705	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S15_08705	COG1902	pentaerythritol trinitrate reductase activity
M1S15_08715	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S15_08745	COG1309	transcriptional regulator
M1S15_08755	COG1335	isochorismatase
M1S15_08760	COG0583	DNA-binding transcription factor activity
M1S15_08770	COG0475	glutathione-regulated potassium exporter activity
M1S15_08770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S15_08780	COG1473	amidohydrolase
M1S15_08790	COG2831	hemolysin activation secretion protein
M1S15_08795	COG3210	domain, Protein
M1S15_08825	COG2188	Transcriptional regulator
M1S15_08840	COG0583	DNA-binding transcription factor activity
M1S15_08870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S15_09055	COG5410	chromosome segregation
M1S15_09250	COG1566	PFAM secretion protein HlyD family protein
M1S15_09265	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_09270	COG0129	dihydroxy-acid dehydratase activity
M1S15_09280	COG0583	DNA-binding transcription factor activity
M1S15_09285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S15_09295	COG2084	Dehydrogenase
M1S15_09300	COG2207	Transcriptional regulator
M1S15_09315	COG1064	alcohol dehydrogenase
M1S15_09325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S15_09330	COG1120	ATPase activity
M1S15_09350	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S15_09470	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S15_09520	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_09535	COG2207	Transcriptional regulator
M1S15_09545	COG2205	protein histidine kinase activity
M1S15_09550	COG0745	RESPONSE REGULATOR receiver
M1S15_09555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S15_09560	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S15_09565	COG1538	Outer membrane efflux protein
M1S15_09575	COG2072	flavoprotein involved in K transport
M1S15_09595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S15_09615	COG3539	Fimbrial protein
M1S15_09645	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S15_09655	COG0753	catalase activity
M1S15_09670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S15_09730	COG3433	isochorismatase activity
M1S15_09730	COG1535	isochorismatase
M1S15_09735	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_09740	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S15_09745	COG4149	molybdate abc transporter
M1S15_09750	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S15_09760	COG4638	Rieske (2fe-2S)
M1S15_09765	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S15_09770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S15_09770	COG0543	2 iron, 2 sulfur cluster binding
M1S15_09795	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_09810	COG2207	Transcriptional regulator
M1S15_09820	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_09825	COG2610	gluconate transmembrane transporter activity
M1S15_09835	COG0583	DNA-binding transcription factor activity
M1S15_09845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S15_09850	COG2031	fatty acid transporter
M1S15_09855	COG0183	Belongs to the thiolase family
M1S15_09860	COG0583	DNA-binding transcription factor activity
M1S15_09865	COG0583	DNA-binding transcription factor activity
M1S15_09880	COG1027	Aspartate ammonia-lyase
M1S15_09890	COG0477	Major facilitator Superfamily
M1S15_09910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S15_09915	COG4521	taurine ABC transporter
M1S15_09930	COG2188	Transcriptional regulator
M1S15_09940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S15_09945	COG1733	regulation of RNA biosynthetic process
M1S15_09950	COG3708	Transcriptional regulator
M1S15_09950	COG2207	Transcriptional regulator
M1S15_09965	COG0730	response to heat
M1S15_09980	COG3453	Protein conserved in bacteria
M1S15_09980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S15_09990	COG3781	membrane
M1S15_09995	COG1063	alcohol dehydrogenase
M1S15_10005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S15_10010	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S15_10015	COG0022	dehydrogenase e1 component
M1S15_10020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S15_10025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S15_10040	COG3706	GGDEF domain
M1S15_10055	COG0133	tryptophan synthase activity
M1S15_10065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S15_10100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S15_10125	COG2226	methyltransferase
M1S15_10180	COG0842	Transport permease protein
M1S15_10185	COG0842	Transport permease protein
M1S15_10190	COG1131	(ABC) transporter
M1S15_10210	COG4773	Receptor
M1S15_10230	COG0730	response to heat
M1S15_10235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S15_10255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S15_10270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S15_10310	COG4264	IucA IucC family
M1S15_10315	COG4264	IucA IucC family
M1S15_10335	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S15_10350	COG1960	acyl-CoA dehydrogenase activity
M1S15_10355	COG1960	acyl-CoA dehydrogenase activity
M1S15_10360	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S15_10365	COG2207	Transcriptional regulator
M1S15_10370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S15_10375	COG0776	regulation of translation
M1S15_10400	COG0822	iron-sulfur transferase activity
M1S15_10405	COG0316	Belongs to the HesB IscA family
M1S15_10435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S15_10455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S15_10460	COG0702	epimerase
M1S15_10495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S15_10505	COG0339	signal peptide processing
M1S15_10555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S15_10560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S15_10590	COG0776	regulation of translation
M1S15_10655	COG0084	hydrolase, TatD family'
M1S15_10675	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S15_10680	COG1132	(ABC) transporter
M1S15_10690	COG0811	peptide transport
M1S15_10695	COG1475	DNA binding
M1S15_10700	COG1192	Involved in chromosome partitioning
M1S15_10710	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S15_10725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S15_10730	COG0191	fructose-bisphosphate aldolase activity
M1S15_10750	COG0424	maF-like protein
M1S15_10755	COG2850	peptidyl-arginine hydroxylation
M1S15_10765	COG0640	Transcriptional regulator
M1S15_10775	COG3619	membrane
M1S15_10780	COG3122	Protein conserved in bacteria
M1S15_10785	COG1132	(ABC) transporter
M1S15_10805	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S15_10810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S15_10820	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S15_10820	COG0506	proline dehydrogenase activity
M1S15_10820	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S15_10825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S15_10840	COG3698	Phosphodiester glycosidase
M1S15_10850	COG2353	YceI-like domain
M1S15_10860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S15_10905	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S15_10905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S15_10930	COG3539	Fimbrial protein
M1S15_10935	COG3121	Chaperone
M1S15_10960	COG0697	spore germination
M1S15_10980	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S15_10990	COG0583	DNA-binding transcription factor activity
M1S15_11010	COG1309	transcriptional regulator
M1S15_11025	COG1522	sequence-specific DNA binding
M1S15_11035	COG1126	abc transporter atp-binding protein
M1S15_11040	COG0765	amino acid transport
M1S15_11045	COG0765	amino acid transport
M1S15_11075	COG1464	Belongs to the NlpA lipoprotein family
M1S15_11085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S15_11090	COG2011	ABC-type metal ion transport system permease component
M1S15_11095	COG0012	GTP binding
M1S15_11120	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S15_11160	COG0386	Belongs to the glutathione peroxidase family
M1S15_11170	COG0436	Aminotransferase
M1S15_11210	COG3634	alkyl hydroperoxide reductase activity
M1S15_11225	COG0583	DNA-binding transcription factor activity
M1S15_11230	COG0798	PFAM Bile acid sodium symporter
M1S15_11235	COG0640	Transcriptional regulator
M1S15_11250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S15_11260	COG0583	DNA-binding transcription factor activity
M1S15_11270	COG1953	Uracil, thiamine, allantoin
M1S15_11280	COG2175	clavaminate synthase activity
M1S15_11285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S15_11290	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S15_11295	COG4521	taurine ABC transporter
M1S15_11305	COG0477	Major facilitator Superfamily
M1S15_11325	COG1271	oxidase subunit
M1S15_11330	COG1294	oxidase, subunit
M1S15_11340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S15_11360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S15_11380	COG3052	prosthetic group binding
M1S15_11385	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S15_11415	COG1346	cytolysis
M1S15_11425	COG0583	DNA-binding transcription factor activity
M1S15_11430	COG0625	glutathione transferase activity
M1S15_11435	COG0625	glutathione transferase activity
M1S15_11440	COG0583	DNA-binding transcription factor activity
M1S15_11455	COG1045	serine acetyltransferase
M1S15_11460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S15_11465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S15_11475	COG1280	lysine exporter protein (LysE YggA)
M1S15_11490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S15_11495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S15_11500	COG1126	abc transporter atp-binding protein
M1S15_11505	COG0765	amino acid transport
M1S15_11510	COG0765	amino acid transport
M1S15_11550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S15_11570	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_11620	COG0583	DNA-binding transcription factor activity
M1S15_11650	COG0318	PFAM AMP-dependent synthetase and ligase
M1S15_11655	COG1309	transcriptional regulator
M1S15_11660	COG1960	acyl-CoA dehydrogenase activity
M1S15_11665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S15_11670	COG1024	Enoyl-CoA hydratase
M1S15_11675	COG4770	biotin carboxylase activity
M1S15_11685	COG0583	DNA-binding transcription factor activity
M1S15_11700	COG1960	acyl-CoA dehydrogenase activity
M1S15_11710	COG2814	Major facilitator Superfamily
M1S15_11720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S15_11725	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S15_11730	COG2814	Major facilitator Superfamily
M1S15_11735	COG1960	acyl-CoA dehydrogenase activity
M1S15_11740	COG1024	Enoyl-CoA hydratase
M1S15_11745	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_11750	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S15_11755	COG0183	Belongs to the thiolase family
M1S15_11765	COG2814	Major facilitator Superfamily
M1S15_11775	COG1024	Enoyl-CoA hydratase
M1S15_11790	COG1960	acyl-CoA dehydrogenase activity
M1S15_11795	COG2814	Major facilitator Superfamily
M1S15_11800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S15_11805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S15_11820	COG3842	ATPase activity
M1S15_11825	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S15_11835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S15_11840	COG1414	Transcriptional regulator
M1S15_11850	COG0583	DNA-binding transcription factor activity
M1S15_11855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S15_11860	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_11870	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S15_11880	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_11885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S15_11890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S15_11895	COG2267	carboxylic ester hydrolase activity
M1S15_11915	COG3038	cytochrome b561
M1S15_11920	COG0753	catalase activity
M1S15_11955	COG2050	protein possibly involved in aromatic compounds catabolism
M1S15_11965	COG3327	negative regulation of DNA-templated transcription, initiation
M1S15_11970	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S15_11975	COG0183	Belongs to the thiolase family
M1S15_11980	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S15_11985	COG1024	Enoyl-CoA hydratase
M1S15_11990	COG1024	Enoyl-CoA hydratase
M1S15_11995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S15_12000	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S15_12005	COG3396	Phenylacetate-CoA oxygenase
M1S15_12010	COG3460	Phenylacetate-CoA oxygenase
M1S15_12015	COG3396	Phenylacetate-CoA oxygenase
M1S15_12020	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_12020	COG2030	dehydratase
M1S15_12025	COG1760	l-serine dehydratase
M1S15_12030	COG0531	amino acid
M1S15_12035	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_12050	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S15_12060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S15_12080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S15_12090	COG0789	Transcriptional regulator
M1S15_12105	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S15_12120	COG2807	transmembrane transport
M1S15_12125	COG0590	tRNA wobble adenosine to inosine editing
M1S15_12245	COG1116	anion transmembrane transporter activity
M1S15_12250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S15_12260	COG0864	Transcriptional regulator
M1S15_12280	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S15_12285	COG0439	Biotin carboxylase
M1S15_12300	COG1063	alcohol dehydrogenase
M1S15_12310	COG1309	transcriptional regulator
M1S15_12330	COG0038	chloride channel
M1S15_12335	COG4770	biotin carboxylase activity
M1S15_12355	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S15_12360	COG0583	DNA-binding transcription factor activity
M1S15_12410	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S15_12430	COG2814	Major facilitator Superfamily
M1S15_12445	COG1560	Kdo2-lipid A biosynthetic process
M1S15_12455	COG5006	permease, DMT superfamily
M1S15_12460	COG1522	sequence-specific DNA binding
M1S15_12475	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S15_12485	COG4122	O-methyltransferase activity
M1S15_12515	COG1538	Outer membrane efflux protein
M1S15_12520	COG1137	ATPase activity
M1S15_12525	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S15_12535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S15_12540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S15_12540	COG0517	IMP dehydrogenase activity
M1S15_12575	COG2814	Major facilitator Superfamily
M1S15_12610	COG1278	Cold shock
M1S15_12615	COG1280	lysine exporter protein (LysE YggA)
M1S15_12645	COG1570	exodeoxyribonuclease VII activity
M1S15_12695	COG0583	DNA-binding transcription factor activity
M1S15_12705	COG4638	Rieske (2fe-2S)
M1S15_12710	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S15_12715	COG0633	Ferredoxin
M1S15_12715	COG0543	2 iron, 2 sulfur cluster binding
M1S15_12720	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_12725	COG3135	benzoate transporter
M1S15_12730	COG2814	Major facilitator Superfamily
M1S15_12745	COG1643	Atp-dependent helicase
M1S15_12750	COG0450	alkyl hydroperoxide reductase
M1S15_12760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S15_12770	COG3634	alkyl hydroperoxide reductase activity
M1S15_12790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S15_12795	COG0625	glutathione transferase activity
M1S15_12805	COG2885	chlorophyll binding
M1S15_12840	COG0542	response to heat
M1S15_12855	COG1765	OsmC-like protein
M1S15_12890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S15_12900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S15_12910	COG0527	aspartate kinase activity
M1S15_12920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S15_12930	COG3038	cytochrome b561
M1S15_12935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S15_12940	COG2252	PERMEase
M1S15_12950	COG2072	flavoprotein involved in K transport
M1S15_12965	COG1741	Belongs to the pirin family
M1S15_12970	COG1309	transcriptional regulator
M1S15_13065	COG0300	oxidoreductase activity
M1S15_13100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S15_13150	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_13170	COG0531	amino acid
M1S15_13180	COG1113	amino acid transport
M1S15_13220	COG3209	COG3209 Rhs family protein
M1S15_13250	COG4269	membrane
M1S15_13265	COG1902	pentaerythritol trinitrate reductase activity
M1S15_13265	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S15_13275	COG2203	Gaf domain
M1S15_13275	COG3706	GGDEF domain
M1S15_13275	COG4251	negative regulation of phosphorylation
M1S15_13275	COG5001	Diguanylate cyclase
M1S15_13285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S15_13305	COG4172	Belongs to the ABC transporter superfamily
M1S15_13310	COG4239	(ABC) transporter, permease
M1S15_13315	COG4174	ABC transporter (Permease)
M1S15_13325	COG1388	LysM domain
M1S15_13325	COG1388	LysM domain
M1S15_13325	COG0741	lytic transglycosylase activity
M1S15_13325	COG0741	lytic transglycosylase activity
M1S15_13330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S15_13370	COG0583	DNA-binding transcription factor activity
M1S15_13375	COG1279	arginine transmembrane transporter activity
M1S15_13395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S15_13400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S15_13405	COG0006	proline dipeptidase activity
M1S15_13490	COG0739	heme binding
M1S15_13815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S15_13840	COG3384	dioxygenase
M1S15_13850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S15_13855	COG2878	Part of a membrane complex involved in electron transport
M1S15_13860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S15_13885	COG0768	penicillin binding
M1S15_13890	COG0742	ribosomal rna small subunit methyltransferase
M1S15_13905	COG0830	nickel cation binding
M1S15_13915	COG0804	urea catabolic process
M1S15_13955	COG1253	flavin adenine dinucleotide binding
M1S15_13960	COG2851	Citrate transporter
M1S15_14010	COG1773	rubredoxin
M1S15_14015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S15_14025	COG0583	DNA-binding transcription factor activity
M1S15_14050	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S15_14055	COG4181	ATPase activity
M1S15_14100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S15_14120	COG0306	phosphate transporter
M1S15_14130	COG3958	Transketolase
M1S15_14135	COG3959	Transketolase, thiamine diphosphate binding domain
M1S15_14140	COG2271	Major facilitator Superfamily
M1S15_14145	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_14150	COG0583	DNA-binding transcription factor activity
M1S15_14165	COG2223	nitrite transmembrane transporter activity
M1S15_14170	COG2207	Transcriptional regulator
M1S15_14175	COG2066	Belongs to the glutaminase family
M1S15_14180	COG0242	peptide deformylase activity
M1S15_14185	COG0477	Major facilitator Superfamily
M1S15_14195	COG0028	Belongs to the TPP enzyme family
M1S15_14210	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_14215	COG2267	carboxylic ester hydrolase activity
M1S15_14225	COG2271	Major facilitator Superfamily
M1S15_14230	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S15_14240	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_14260	COG1414	Transcriptional regulator
M1S15_14275	COG1024	Enoyl-CoA hydratase
M1S15_14285	COG1215	transferase activity, transferring glycosyl groups
M1S15_14290	COG0726	polysaccharide deacetylase
M1S15_14290	COG1649	PFAM Uncharacterised BCR, COG1649
M1S15_14300	COG4681	YaeQ
M1S15_14310	COG0523	cobalamin synthesis protein
M1S15_14320	COG1607	acyl-coa hydrolase
M1S15_14330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S15_14335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S15_14340	COG1309	transcriptional regulator
M1S15_14365	COG2040	homocysteine
M1S15_14370	COG0531	amino acid
M1S15_14395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S15_14400	COG0477	Major facilitator Superfamily
M1S15_14460	COG1061	Type III restriction enzyme res subunit
M1S15_14470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S15_14475	COG1192	Involved in chromosome partitioning
M1S15_14485	COG1061	Type III restriction enzyme res subunit
M1S15_14575	COG0592	DNA-directed DNA polymerase activity
M1S15_14615	COG2026	Addiction module toxin, RelE StbE family
M1S15_14770	COG3755	Protein conserved in bacteria
M1S15_14815	COG1484	DNA-dependent DNA replication
M1S15_14905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S15_14975	COG0405	Gamma-glutamyltransferase
M1S15_14980	COG2814	Major facilitator Superfamily
M1S15_14990	COG2050	protein possibly involved in aromatic compounds catabolism
M1S15_15005	COG1090	epimerase
M1S15_15025	COG0420	3'-5' exonuclease activity
M1S15_15050	COG0735	belongs to the Fur family
M1S15_15055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S15_15075	COG0121	glutamine amidotransferase
M1S15_15095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S15_15105	COG0210	DNA helicase
M1S15_15110	COG2885	chlorophyll binding
M1S15_15115	COG0204	Acyl-transferase
M1S15_15130	COG2894	cell division
M1S15_15150	COG1280	lysine exporter protein (LysE YggA)
M1S15_15155	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S15_15155	COG1674	ftsk spoiiie
M1S15_15160	COG0492	ferredoxin-NADP+ reductase activity
M1S15_15165	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S15_15175	COG0456	acetyltransferase
M1S15_15220	COG1981	membrane
M1S15_15235	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S15_15235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S15_15265	COG0657	acetylesterase activity
M1S15_15275	COG0473	3-isopropylmalate dehydrogenase activity
M1S15_15280	COG0583	DNA-binding transcription factor activity
M1S15_15300	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S15_15325	COG0564	pseudouridine synthase activity
M1S15_15335	COG0358	DNA primase activity
M1S15_15350	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S15_15380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S15_15410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S15_15420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S15_15420	COG0352	thiamine-phosphate diphosphorylase activity
M1S15_15420	COG0351	phosphomethylpyrimidine kinase
M1S15_15425	COG1652	LysM domain
M1S15_15450	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S15_15455	COG3101	peptidyl-lysine hydroxylation
M1S15_15460	COG0009	L-threonylcarbamoyladenylate synthase
M1S15_15465	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S15_15470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S15_15485	COG4106	trans-aconitate 2-methyltransferase activity
M1S15_15500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S15_15500	COG2226	methyltransferase
M1S15_15500	COG0596	Alpha beta hydrolase
M1S15_15505	COG1877	trehalose-phosphatase activity
M1S15_15510	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S15_15515	COG2223	nitrite transmembrane transporter activity
M1S15_15535	COG1196	nuclear chromosome segregation
M1S15_15545	COG0730	response to heat
M1S15_15560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S15_15570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S15_15620	COG0489	protein tyrosine kinase activity
M1S15_15630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S15_15630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S15_15660	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S15_15665	COG2081	HI0933 family
M1S15_15675	COG0668	transmembrane transport
M1S15_15695	COG0583	DNA-binding transcription factor activity
M1S15_15715	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S15_15720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S15_15750	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S15_15790	COG0745	RESPONSE REGULATOR receiver
M1S15_15810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S15_15820	COG2205	protein histidine kinase activity
M1S15_15890	COG4993	Dehydrogenase
M1S15_15915	COG0384	phenazine biosynthesis protein PhzF
M1S15_15940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S15_15955	COG0583	DNA-binding transcription factor activity
M1S15_15985	COG0583	DNA-binding transcription factor activity
M1S15_16000	COG0583	DNA-binding transcription factor activity
M1S15_16005	COG1053	succinate dehydrogenase
M1S15_16015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S15_16020	COG2814	Major facilitator Superfamily
M1S15_16025	COG1960	acyl-CoA dehydrogenase activity
M1S15_16030	COG0583	DNA-binding transcription factor activity
M1S15_16035	COG1063	alcohol dehydrogenase
M1S15_16065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S15_16070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S15_16075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S15_16090	COG3667	copper resistance
M1S15_16095	COG2132	Multicopper oxidase
M1S15_16105	COG0561	phosphatase activity
M1S15_16110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S15_16135	COG1214	PFAM Peptidase M22, glycoprotease
M1S15_16185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S15_16195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S15_16200	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S15_16205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S15_16265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S15_16275	COG1846	Transcriptional regulator
M1S15_16280	COG1764	response to oxidative stress
M1S15_16320	COG0037	tRNA processing
M1S15_16330	COG0248	Ppx GppA phosphatase
M1S15_16360	COG0072	phenylalanine-tRNA ligase activity
M1S15_16405	COG1238	metal cluster binding
M1S15_16410	COG0625	glutathione transferase activity
M1S15_16425	COG0318	PFAM AMP-dependent synthetase and ligase
M1S15_16430	COG3028	Belongs to the UPF0307 family
M1S15_16435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S15_16455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S15_16460	COG0617	tRNA 3'-terminal CCA addition
M1S15_16465	COG1555	photosystem II stabilization
M1S15_16470	COG3956	TIGRFAM MazG family protein
M1S15_16480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S15_16500	COG5002	protein histidine kinase activity
M1S15_16500	COG2205	protein histidine kinase activity
M1S15_16500	COG0784	Response regulator, receiver
M1S15_16505	COG1024	Enoyl-CoA hydratase
M1S15_16510	COG2084	Dehydrogenase
M1S15_16515	COG3622	Belongs to the hyi family
M1S15_16545	COG0697	spore germination
M1S15_16555	COG2814	Major facilitator Superfamily
M1S15_16560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S15_16570	COG0583	DNA-binding transcription factor activity
M1S15_16580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S15_16595	COG0084	hydrolase, TatD family'
M1S15_16610	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S15_16640	COG0440	acetolactate synthase activity
M1S15_16645	COG0028	Belongs to the TPP enzyme family
M1S15_16670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S15_16675	COG0577	efflux transmembrane transporter activity
M1S15_16675	COG1136	(ABC) transporter
M1S15_16680	COG1538	Outer membrane efflux protein
M1S15_16695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S15_16700	COG1162	GTPase activity
M1S15_16710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S15_16730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S15_16735	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_16775	COG2986	histidine ammonia-lyase
M1S15_16790	COG0318	PFAM AMP-dependent synthetase and ligase
M1S15_16800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S15_16845	COG1426	Protein conserved in bacteria
M1S15_16880	COG0793	Belongs to the peptidase S41A family
M1S15_16895	COG2267	carboxylic ester hydrolase activity
M1S15_16905	COG1012	belongs to the aldehyde dehydrogenase family
M1S15_16910	COG3265	gluconokinase activity
M1S15_16920	COG0800	Aldolase
M1S15_16930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S15_16935	COG0857	belongs to the CobB CobQ family
M1S15_16935	COG0280	phosphate acetyltransferase
M1S15_16940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S15_16940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S15_16960	COG0740	serine-type endopeptidase activity
M1S15_16970	COG4774	siderophore transport
M1S15_16980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S15_16990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S15_16990	COG2813	Specifically methylates the guanine in position
M1S15_17090	COG0788	formyltetrahydrofolate deformylase activity
M1S15_17115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S15_17115	COG4651	solute:proton antiporter activity
M1S15_17135	COG0724	RNA recognition motif
M1S15_17140	COG0210	DNA helicase
M1S15_17165	COG1733	regulation of RNA biosynthetic process
M1S15_17175	COG2900	Belongs to the SlyX family
M1S15_17180	COG0488	(ABC) transporter
M1S15_17185	COG1280	lysine exporter protein (LysE YggA)
M1S15_17190	COG1560	Kdo2-lipid A biosynthetic process
M1S15_17200	COG1301	dicarboxylic acid transport
M1S15_17255	COG0473	3-isopropylmalate dehydrogenase activity
M1S15_17320	COG0583	DNA-binding transcription factor activity
M1S15_17330	COG0625	glutathione transferase activity
M1S15_17335	COG2378	regulation of single-species biofilm formation
M1S15_17340	COG0546	phosphoglycolate phosphatase activity
M1S15_17350	COG1530	ribonuclease E activity
M1S15_17355	COG0318	PFAM AMP-dependent synthetase and ligase
M1S15_17370	COG0583	DNA-binding transcription factor activity
M1S15_17375	COG4221	oxidoreductase activity
M1S15_17380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S15_17390	COG0534	Mate efflux family protein
M1S15_17405	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S15_17445	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S15_17450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S15_17465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S15_17475	COG0644	oxidoreductase
M1S15_17475	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S15_17480	COG0425	Belongs to the sulfur carrier protein TusA family
M1S15_17485	COG4535	Mg2 and Co2 transporter CorC
M1S15_17495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S15_17515	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S15_17520	COG0475	glutathione-regulated potassium exporter activity
M1S15_17520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S15_17525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S15_17550	COG0789	Transcriptional regulator
M1S15_17555	COG0598	Magnesium transport protein CorA
M1S15_17570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S15_17575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S15_17580	COG1074	ATP-dependent DNA helicase activity
M1S15_17585	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S15_17605	COG2226	methyltransferase
M1S15_17620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S15_17625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S15_17640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S15_17640	COG2111	Na H antiporter
M1S15_17645	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S15_17650	COG0651	ATP synthesis coupled electron transport
M1S15_17655	COG1863	multisubunit Na H antiporter MnhE subunit
M1S15_17660	COG2212	antiporter activity
M1S15_17665	COG1320	monovalent cation:proton antiporter activity
M1S15_17680	COG0195	Participates in both transcription termination and antitermination
M1S15_17730	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S15_17745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S15_17760	COG0497	DNA recombination
M1S15_17770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S15_17800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S15_17800	COG2169	Transcriptional regulator
M1S15_17805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S15_17870	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S15_17885	COG0326	Molecular chaperone. Has ATPase activity
M1S15_17900	COG2056	Na+-H+ antiporter family
M1S15_17905	COG0596	Alpha beta hydrolase
M1S15_18000	COG0546	phosphoglycolate phosphatase activity
M1S15_18005	COG1716	ATPase activity
M1S15_18050	COG0181	hydroxymethylbilane synthase activity
M1S15_18060	COG3275	phosphorelay sensor kinase activity
M1S15_18080	COG1538	Outer membrane efflux protein
M1S15_18085	COG0697	spore germination
M1S15_18110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S15_18115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S15_18120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S15_18125	COG0772	Belongs to the SEDS family
M1S15_18150	COG4974	Belongs to the 'phage' integrase family
M1S15_18155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S15_18165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S15_18175	COG2197	response regulator
M1S15_18190	COG0793	Belongs to the peptidase S41A family
M1S15_18195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S15_18200	COG0795	lipopolysaccharide-transporting ATPase activity
M1S15_18240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S15_18240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S15_18250	COG0004	ammonium transporteR
M1S15_18255	COG0347	Belongs to the P(II) protein family
M1S15_18315	COG0659	secondary active sulfate transmembrane transporter activity
M1S15_18320	COG0589	response to stress
M1S15_18370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S15_18400	COG0659	secondary active sulfate transmembrane transporter activity
M1S15_18405	COG0589	response to stress
M1S15_18460	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S15_18490	COG0659	secondary active sulfate transmembrane transporter activity
M1S15_18495	COG0589	response to stress
M1S15_18530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S15_18540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S15_18560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S15_18575	COG0318	PFAM AMP-dependent synthetase and ligase
M1S15_18585	COG0477	Major facilitator Superfamily
M1S15_18590	COG2860	membrane
M1S15_18600	COG1253	flavin adenine dinucleotide binding
M1S15_18620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S15_18660	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S15_18670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S15_18740	COG0758	DNA mediated transformation
M1S15_18750	COG0697	spore germination
M1S15_18755	COG1309	transcriptional regulator
M1S15_18770	COG0386	Belongs to the glutathione peroxidase family
M1S15_18835	COG1121	(ABC) transporter
M1S15_18840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S15_18845	COG1280	lysine exporter protein (LysE YggA)
M1S15_18850	COG2837	iron assimilation
M1S15_18860	COG0281	malic enzyme
M1S15_18905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S15_18905	COG0519	Catalyzes the synthesis of GMP from XMP
M1S15_18910	COG4399	Belongs to the UPF0754 family
M1S15_18915	COG2259	Doxx family
M1S15_18920	COG0586	Pfam SNARE associated Golgi protein
M1S15_18935	COG1192	Involved in chromosome partitioning
M1S15_18945	COG0271	Belongs to the BolA IbaG family
M1S15_18965	COG2267	carboxylic ester hydrolase activity
M1S15_18985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S15_18985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S15_18985	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S15_18985	COG3321	synthase
M1S15_18990	COG1960	acyl-CoA dehydrogenase activity
M1S15_19000	COG2197	response regulator
M1S15_19010	COG3916	Acyl-homoserine-lactone synthase
M1S15_19015	COG0477	Major facilitator Superfamily
M1S15_19020	COG1024	Enoyl-CoA hydratase
M1S15_19025	COG1024	Enoyl-CoA hydratase
M1S15_19030	COG1960	acyl-CoA dehydrogenase activity
M1S15_19035	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S15_19055	COG1113	amino acid transport
M1S15_19060	COG1113	amino acid transport
M1S15_19065	COG0251	oxidation-reduction process
M1S15_19105	COG0564	pseudouridine synthase activity
M1S15_19165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S15_19180	COG1802	Transcriptional regulator
M1S15_19190	COG1448	Aminotransferase
M1S15_19195	COG0277	FAD linked oxidase domain protein
M1S15_19205	COG2186	Transcriptional regulator
M1S15_19215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S15_19220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S15_19235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S15_19240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S15_19245	COG1216	Glycosyl transferase, family 2
M1S15_19275	COG2089	acid synthase
M1S15_19290	COG1083	cytidylyl-transferase
M1S15_19295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S15_19300	COG1086	Polysaccharide biosynthesis protein
M1S15_19305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S15_19310	COG1596	polysaccharide export
M1S15_19335	COG0728	peptidoglycan biosynthetic process
M1S15_19340	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S15_19400	COG0546	phosphoglycolate phosphatase activity
M1S15_19405	COG1028	Short-chain dehydrogenase reductase Sdr
M1S15_19425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S15_19430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S15_19435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S15_19440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S15_19445	COG1116	anion transmembrane transporter activity
M1S15_19450	COG1309	transcriptional regulator
M1S15_19455	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S15_19465	COG0196	riboflavin kinase activity
M1S15_19470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S15_19480	COG1047	Peptidyl-prolyl cis-trans
M1S15_19520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S15_19525	COG0657	acetylesterase activity
M1S15_19545	COG0583	DNA-binding transcription factor activity
M1S15_19575	COG2951	lytic endotransglycosylase activity
M1S15_19580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S15_19595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S15_19605	COG0671	phosphoesterase, PA-phosphatase related
M1S15_19610	COG0861	Integral membrane protein TerC family
M1S15_19620	COG0754	glutathionylspermidine amidase activity
M1S15_19630	COG0402	S-adenosylhomocysteine deaminase activity
M1S15_19645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S15_19650	COG1230	cation diffusion facilitator family transporter
M1S15_19665	COG0706	membrane insertase activity
M1S15_19705	COG0358	DNA primase activity
M1S15_19760	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S15_19805	COG0587	DNA-directed DNA polymerase activity
M1S15_19820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S15_19820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S15_19870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S15_19870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S15_19875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S15_19915	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S15_19960	COG1309	transcriptional regulator
M1S15_19970	COG1902	pentaerythritol trinitrate reductase activity
M1S15_19980	COG1979	alcohol dehydrogenase
M1S15_19995	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S15_20020	COG1063	alcohol dehydrogenase
M1S15_20100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S15_20120	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system