locus-tag	class	description
M1S52_00010	COG0592	DNA-directed DNA polymerase activity
M1S52_00020	COG0187	DNA topoisomerase II activity
M1S52_00030	COG0586	Pfam SNARE associated Golgi protein
M1S52_00035	COG0488	(ABC) transporter
M1S52_00060	COG0596	Alpha beta hydrolase
M1S52_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S52_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S52_00160	COG2233	PERMEase
M1S52_00175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S52_00210	COG2814	Major facilitator Superfamily
M1S52_00215	COG0656	L-ascorbic acid biosynthetic process
M1S52_00220	COG0583	DNA-binding transcription factor activity
M1S52_00235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S52_00240	COG1064	alcohol dehydrogenase
M1S52_00245	COG2818	Glycosylase
M1S52_00260	COG1194	a g-specific adenine glycosylase
M1S52_00280	COG2983	Belongs to the UPF0260 family
M1S52_00285	COG2133	pyrroloquinoline quinone binding
M1S52_00290	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S52_00295	COG2116	formate transmembrane transporter activity
M1S52_00315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S52_00320	COG1335	isochorismatase
M1S52_00325	COG0385	Bile acid
M1S52_00330	COG0534	Mate efflux family protein
M1S52_00335	COG1683	Conserved Protein
M1S52_00355	COG0625	glutathione transferase activity
M1S52_00365	COG1113	amino acid transport
M1S52_00375	COG0523	cobalamin synthesis protein
M1S52_00385	COG2188	Transcriptional regulator
M1S52_00415	COG0010	Belongs to the arginase family
M1S52_00430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S52_00435	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S52_00445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S52_00450	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S52_00550	COG0534	Mate efflux family protein
M1S52_00555	COG0436	Aminotransferase
M1S52_00560	COG2733	membrane
M1S52_00575	COG2918	glutathione biosynthetic process
M1S52_00590	COG1388	LysM domain
M1S52_00590	COG0791	NLP P60 protein
M1S52_00605	COG3150	esterase
M1S52_00615	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_00620	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S52_00630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S52_00640	COG2233	PERMEase
M1S52_00645	COG2351	hydroxyisourate hydrolase activity
M1S52_00680	COG3706	GGDEF domain
M1S52_00695	COG1393	Belongs to the ArsC family
M1S52_00700	COG0708	Exodeoxyribonuclease III
M1S52_00720	COG0189	ligase activity
M1S52_00740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S52_00750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S52_00765	COG4942	peptidase
M1S52_00775	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S52_00785	COG2119	membrane
M1S52_00790	COG4774	siderophore transport
M1S52_00795	COG0426	domain, Protein
M1S52_00795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S52_00820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S52_00840	COG1902	pentaerythritol trinitrate reductase activity
M1S52_00845	COG1519	Transferase
M1S52_00850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S52_00855	COG0668	transmembrane transport
M1S52_00875	COG1522	sequence-specific DNA binding
M1S52_00880	COG3328	transposase activity
M1S52_00905	COG0784	Response regulator, receiver
M1S52_00905	COG2198	Histidine kinase
M1S52_00905	COG2205	protein histidine kinase activity
M1S52_00910	COG3162	membrane
M1S52_00915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S52_00925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S52_00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S52_00950	COG1309	transcriptional regulator
M1S52_00970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S52_00970	COG0352	thiamine-phosphate diphosphorylase activity
M1S52_00970	COG0351	phosphomethylpyrimidine kinase
M1S52_00980	COG2814	Major facilitator Superfamily
M1S52_00995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S52_01005	COG1113	amino acid transport
M1S52_01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S52_01020	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_01030	COG1335	isochorismatase
M1S52_01060	COG2814	Major facilitator Superfamily
M1S52_01065	COG0583	DNA-binding transcription factor activity
M1S52_01085	COG0667	Aldo Keto reductase
M1S52_01120	COG1733	regulation of RNA biosynthetic process
M1S52_01125	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S52_01190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S52_01205	COG2329	Antibiotic biosynthesis monooxygenase
M1S52_01235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S52_01265	COG0427	acetyl-CoA hydrolase
M1S52_01290	COG0659	secondary active sulfate transmembrane transporter activity
M1S52_01295	COG4221	oxidoreductase activity
M1S52_01300	COG2873	o-acetylhomoserine
M1S52_01305	COG0488	(ABC) transporter
M1S52_01425	COG3328	transposase activity
M1S52_01490	COG0582	viral genome integration into host DNA
M1S52_01510	COG0833	amino acid
M1S52_01555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S52_01560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S52_01575	COG2226	methyltransferase
M1S52_01625	COG0067	glutamate synthase
M1S52_01625	COG0069	glutamate synthase activity
M1S52_01625	COG0070	glutamate synthase
M1S52_01630	COG0493	'glutamate synthase
M1S52_01640	COG1704	LemA family
M1S52_01645	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S52_01665	COG3307	-O-antigen
M1S52_01685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S52_01700	COG0194	GDP metabolic process
M1S52_01750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S52_01770	COG5380	lipid catabolic process
M1S52_01775	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S52_01800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S52_01805	COG0277	FAD linked oxidase domain protein
M1S52_01815	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S52_01820	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S52_01835	COG1289	transmembrane transporter activity
M1S52_01845	COG0628	permease
M1S52_01850	COG1192	Involved in chromosome partitioning
M1S52_01880	COG0833	amino acid
M1S52_01885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S52_01890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S52_01900	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_01940	COG0583	DNA-binding transcription factor activity
M1S52_01985	COG0517	IMP dehydrogenase activity
M1S52_01990	COG1983	PspC domain protein
M1S52_02000	COG1960	acyl-CoA dehydrogenase activity
M1S52_02015	COG0408	coproporphyrinogen oxidase activity
M1S52_02035	COG0513	Belongs to the DEAD box helicase family
M1S52_02045	COG1127	ABC transporter
M1S52_02050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S52_02060	COG2854	intermembrane phospholipid transfer
M1S52_02070	COG0598	Magnesium transport protein CorA
M1S52_02080	COG0494	nUDIX hydrolase
M1S52_02085	COG1040	competence protein
M1S52_02090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S52_02110	COG1946	Acyl-CoA thioesterase
M1S52_02115	COG1301	dicarboxylic acid transport
M1S52_02130	COG1959	2 iron, 2 sulfur cluster binding
M1S52_02135	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S52_02135	COG1017	nitric oxide dioxygenase activity
M1S52_02140	COG0433	COG0433 Predicted ATPase
M1S52_02145	COG0626	cystathionine gamma-synthase activity
M1S52_02300	COG1960	acyl-CoA dehydrogenase activity
M1S52_02305	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S52_02335	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S52_02340	COG0339	signal peptide processing
M1S52_02345	COG0557	exoribonuclease II activity
M1S52_02390	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S52_02395	COG2169	Transcriptional regulator
M1S52_02400	COG0697	spore germination
M1S52_02405	COG1295	ribonuclease BN
M1S52_02440	COG1702	phosphate starvation-inducible protein PhoH
M1S52_02450	COG0741	lytic transglycosylase activity
M1S52_02450	COG1196	nuclear chromosome segregation
M1S52_02450	COG0739	heme binding
M1S52_02480	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S52_02485	COG1183	phosphatidylcholine synthase activity
M1S52_02530	COG1960	acyl-CoA dehydrogenase activity
M1S52_02535	COG1309	transcriptional regulator
M1S52_02550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S52_02555	COG1960	acyl-CoA dehydrogenase activity
M1S52_02575	COG2969	positive regulation of protein catabolic process
M1S52_02585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S52_02600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S52_02605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S52_02625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S52_02635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S52_02640	COG1408	metallophosphoesterase
M1S52_02650	COG2199	diguanylate cyclase activity
M1S52_02710	COG1607	acyl-coa hydrolase
M1S52_02740	COG2350	Protein conserved in bacteria
M1S52_02750	COG0613	PHP domain protein
M1S52_02755	COG3781	membrane
M1S52_02765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S52_02770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S52_02780	COG1862	Preprotein translocase
M1S52_02810	COG2205	protein histidine kinase activity
M1S52_02815	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S52_02835	COG0726	polysaccharide deacetylase
M1S52_02840	COG0463	Glycosyl transferase, family 2
M1S52_02845	COG0438	transferase activity, transferring glycosyl groups
M1S52_02910	COG0625	glutathione transferase activity
M1S52_02915	COG0583	DNA-binding transcription factor activity
M1S52_02920	COG1960	acyl-CoA dehydrogenase activity
M1S52_02925	COG1960	acyl-CoA dehydrogenase activity
M1S52_02935	COG2205	protein histidine kinase activity
M1S52_02940	COG0745	RESPONSE REGULATOR receiver
M1S52_02945	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S52_02965	COG2096	Adenosyltransferase
M1S52_03015	COG0285	dihydrofolate synthase activity
M1S52_03035	COG0450	alkyl hydroperoxide reductase
M1S52_03050	COG0477	Major facilitator Superfamily
M1S52_03055	COG1272	protein, Hemolysin III
M1S52_03085	COG0183	Belongs to the thiolase family
M1S52_03090	COG2207	Transcriptional regulator
M1S52_03110	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S52_03130	COG0183	Belongs to the thiolase family
M1S52_03140	COG2885	chlorophyll binding
M1S52_03140	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S52_03150	COG1690	Belongs to the RtcB family
M1S52_03155	COG0833	amino acid
M1S52_03165	COG2233	PERMEase
M1S52_03170	COG1217	gtp-binding protein TYPA
M1S52_03195	COG2094	Belongs to the DNA glycosylase MPG family
M1S52_03215	COG1902	pentaerythritol trinitrate reductase activity
M1S52_03230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S52_03235	COG0354	folic acid binding
M1S52_03245	COG3189	MarR family transcriptional regulator
M1S52_03250	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S52_03255	COG3422	double-strand break repair
M1S52_03295	COG0840	transmembrane signaling receptor activity
M1S52_03315	COG5510	response to toxic substance
M1S52_03325	COG2832	Protein of unknown function (DUF454)
M1S52_03330	COG1376	ErfK ybiS ycfS ynhG family protein
M1S52_03370	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S52_03380	COG1289	transmembrane transporter activity
M1S52_03385	COG2814	Major facilitator Superfamily
M1S52_03405	COG1115	amino acid carrier protein
M1S52_03410	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S52_03415	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S52_03420	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S52_03450	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S52_03460	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S52_03465	COG1077	Cell shape determining protein MreB Mrl
M1S52_03470	COG1792	Involved in formation and maintenance of cell shape
M1S52_03475	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S52_03480	COG0424	maF-like protein
M1S52_03485	COG1530	ribonuclease E activity
M1S52_03495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S52_03505	COG0560	Phosphoserine phosphatase
M1S52_03515	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S52_03540	COG2207	Transcriptional regulator
M1S52_03560	COG1113	amino acid transport
M1S52_03565	COG2828	Protein conserved in bacteria
M1S52_03570	COG0142	geranyltranstransferase activity
M1S52_03575	COG2315	Protein conserved in bacteria
M1S52_03590	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S52_03615	COG0745	RESPONSE REGULATOR receiver
M1S52_03620	COG0642	Histidine kinase
M1S52_03630	COG0004	ammonium transporteR
M1S52_03635	COG0583	DNA-binding transcription factor activity
M1S52_03655	COG0525	valine-tRNA ligase activity
M1S52_03665	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_03675	COG0393	Putative heavy-metal-binding
M1S52_03680	COG0393	Putative heavy-metal-binding
M1S52_03685	COG1538	Outer membrane efflux protein
M1S52_03695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S52_03700	COG0671	phosphoesterase, PA-phosphatase related
M1S52_03730	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S52_03745	COG1648	precorrin-2 dehydrogenase activity
M1S52_03745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S52_03750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S52_03755	COG1733	regulation of RNA biosynthetic process
M1S52_03765	COG0531	amino acid
M1S52_03780	COG0321	lipoyl(octanoyl) transferase activity
M1S52_03785	COG2921	Belongs to the UPF0250 family
M1S52_03825	COG2009	succinate dehydrogenase
M1S52_03830	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S52_03835	COG1053	succinate dehydrogenase
M1S52_03840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S52_03865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S52_03885	COG2354	Protein conserved in bacteria
M1S52_03890	COG2321	neutral zinc metallopeptidase
M1S52_03910	COG2843	Capsule synthesis protein
M1S52_03925	COG0589	response to stress
M1S52_03945	COG0505	Belongs to the CarA family
M1S52_03970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S52_03975	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S52_04025	COG0477	Major facilitator Superfamily
M1S52_04030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S52_04045	COG1597	lipid kinase activity
M1S52_04050	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S52_04080	COG0584	glycerophosphoryl diester phosphodiesterase
M1S52_04100	COG0741	lytic transglycosylase activity
M1S52_04120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S52_04135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S52_04165	COG0778	Nitroreductase
M1S52_04180	COG1929	Belongs to the glycerate kinase type-1 family
M1S52_04185	COG0243	molybdopterin cofactor binding
M1S52_04190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S52_04195	COG3339	Conserved Protein
M1S52_04205	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S52_04220	COG1113	amino acid transport
M1S52_04230	COG0019	diaminopimelate decarboxylase activity
M1S52_04240	COG1280	lysine exporter protein (LysE YggA)
M1S52_04245	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S52_04275	COG0463	Glycosyl transferase, family 2
M1S52_04295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S52_04330	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S52_04335	COG1136	(ABC) transporter
M1S52_04340	COG0658	competence protein
M1S52_04340	COG2333	competence protein COMEC
M1S52_04350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S52_04350	COG0616	signal peptide processing
M1S52_04355	COG0596	Alpha beta hydrolase
M1S52_04360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S52_04370	COG0628	permease
M1S52_04405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S52_04425	COG0823	Involved in the tonB-independent uptake of proteins
M1S52_04445	COG0824	Thioesterase
M1S52_04450	COG1473	amidohydrolase
M1S52_04470	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S52_04470	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S52_04475	COG2814	Major facilitator Superfamily
M1S52_04485	COG1024	Enoyl-CoA hydratase
M1S52_04490	COG1056	cytidyltransferase-related domain
M1S52_04490	COG1051	belongs to the nudix hydrolase family
M1S52_04500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S52_04515	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S52_04530	COG4625	pathogenesis
M1S52_04535	COG0583	DNA-binding transcription factor activity
M1S52_04540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S52_04545	COG4208	sulfate ABC transporter
M1S52_04550	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S52_04560	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S52_04565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S52_04570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S52_04605	COG0681	Belongs to the peptidase S26 family
M1S52_04620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S52_04630	COG1381	Involved in DNA repair and RecF pathway recombination
M1S52_04635	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S52_04645	COG4221	oxidoreductase activity
M1S52_04675	COG0436	Aminotransferase
M1S52_04695	COG0556	nucleotide-excision repair
M1S52_04750	COG2070	2-Nitropropane dioxygenase
M1S52_04780	COG1215	transferase activity, transferring glycosyl groups
M1S52_04795	COG0415	Belongs to the DNA photolyase family
M1S52_04805	COG1252	NADH dehydrogenase
M1S52_04810	COG1686	Belongs to the peptidase S11 family
M1S52_04825	COG1187	pseudouridine synthase activity
M1S52_04850	COG0477	Major facilitator Superfamily
M1S52_04855	COG0583	DNA-binding transcription factor activity
M1S52_04860	COG1823	symporter activity
M1S52_04870	COG0612	Peptidase, M16
M1S52_04895	COG0352	thiamine-phosphate diphosphorylase activity
M1S52_04930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S52_04945	COG1309	transcriptional regulator
M1S52_04955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S52_04960	COG0076	glutamate decarboxylase activity
M1S52_04970	COG1522	sequence-specific DNA binding
M1S52_04975	COG3961	Belongs to the TPP enzyme family
M1S52_04980	COG1113	amino acid transport
M1S52_04985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S52_04990	COG0573	inorganic phosphate transmembrane transporter activity
M1S52_05000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S52_05005	COG0616	signal peptide processing
M1S52_05040	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S52_05045	COG1686	Belongs to the peptidase S11 family
M1S52_05070	COG0583	DNA-binding transcription factor activity
M1S52_05075	COG1067	ATP-dependent peptidase activity
M1S52_05120	COG1966	Carbon starvation protein
M1S52_05125	COG2879	small protein
M1S52_05160	COG2508	Transcriptional regulator
M1S52_05160	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S52_05180	COG1113	amino acid transport
M1S52_05185	COG0583	DNA-binding transcription factor activity
M1S52_05190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S52_05195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S52_05205	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_05215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S52_05220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S52_05220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S52_05255	COG2814	Major facilitator Superfamily
M1S52_05260	COG4948	Mandelate Racemase Muconate Lactonizing
M1S52_05270	COG1309	transcriptional regulator
M1S52_05290	COG1741	Belongs to the pirin family
M1S52_05300	COG2964	Protein conserved in bacteria
M1S52_05315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S52_05320	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S52_05325	COG4605	iron ion homeostasis
M1S52_05330	COG4604	ABC transporter, ATP-binding protein
M1S52_05335	COG4607	ABC-type enterochelin transport system periplasmic component
M1S52_05350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S52_05355	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S52_05360	COG1535	isochorismatase
M1S52_05360	COG3433	isochorismatase activity
M1S52_05375	COG1132	(ABC) transporter
M1S52_05380	COG1132	(ABC) transporter
M1S52_05385	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S52_05395	COG1169	isochorismate synthase
M1S52_05410	COG3739	integral membrane protein
M1S52_05435	COG0302	gtp cyclohydrolase
M1S52_05445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S52_05475	COG0308	aminopeptidase N
M1S52_05480	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S52_05670	COG5410	chromosome segregation
M1S52_05840	COG0582	viral genome integration into host DNA
M1S52_05855	COG0174	glutamine synthetase
M1S52_05865	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S52_05900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S52_05935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S52_05940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S52_05945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S52_05960	COG1960	acyl-CoA dehydrogenase activity
M1S52_05965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S52_05970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S52_05980	COG2223	nitrite transmembrane transporter activity
M1S52_05990	COG0024	Methionine aminopeptidase
M1S52_05995	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S52_06010	COG2207	Transcriptional regulator
M1S52_06035	COG2951	lytic endotransglycosylase activity
M1S52_06040	COG0772	Belongs to the SEDS family
M1S52_06055	COG0842	Transport permease protein
M1S52_06060	COG1131	(ABC) transporter
M1S52_06105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S52_06120	COG4215	(ABC) transporter
M1S52_06125	COG4160	amino acid transport
M1S52_06130	COG4598	ABC transporter
M1S52_06140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S52_06145	COG0826	peptidase U32
M1S52_06150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S52_06165	COG1720	tRNA m6t6A37 methyltransferase activity
M1S52_06175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S52_06190	COG0642	Histidine kinase
M1S52_06200	COG0494	nUDIX hydrolase
M1S52_06210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S52_06215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S52_06220	COG3139	Protein of unknown function (DUF1315)
M1S52_06225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S52_06230	COG1301	dicarboxylic acid transport
M1S52_06235	COG1960	acyl-CoA dehydrogenase activity
M1S52_06240	COG2819	hydrolase of the alpha beta superfamily
M1S52_06250	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S52_06260	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S52_06265	COG1234	tRNA 3'-trailer cleavage
M1S52_06295	COG2363	Small membrane protein
M1S52_06320	COG0513	Belongs to the DEAD box helicase family
M1S52_06330	COG0778	Nitroreductase
M1S52_06360	COG1286	toxin biosynthetic process
M1S52_06385	COG4783	chaperone-mediated protein folding
M1S52_06390	COG1610	YqeY-like protein
M1S52_06490	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S52_06515	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S52_06520	COG0786	glutamate:sodium symporter activity
M1S52_06530	COG2186	Transcriptional regulator
M1S52_06590	COG0477	Major facilitator Superfamily
M1S52_06620	COG2985	domain, Protein
M1S52_06630	COG2995	paraquat-inducible protein a
M1S52_06635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M1S52_06635	COG3008	intermembrane lipid transfer
M1S52_06645	COG1794	racemase activity, acting on amino acids and derivatives
M1S52_06695	COG1301	dicarboxylic acid transport
M1S52_06705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S52_06710	COG2011	ABC-type metal ion transport system permease component
M1S52_06715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S52_06720	COG1464	Belongs to the NlpA lipoprotein family
M1S52_06725	COG0151	Belongs to the GarS family
M1S52_06730	COG0138	bifunctional purine biosynthesis protein purh
M1S52_06735	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S52_06765	COG2308	Evidence 4 Homologs of previously reported genes of
M1S52_06775	COG1305	Transglutaminase-like
M1S52_06785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S52_06790	COG0305	Participates in initiation and elongation during chromosome replication
M1S52_06815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S52_06825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S52_06830	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S52_06855	COG1649	PFAM Uncharacterised BCR, COG1649
M1S52_06855	COG0726	polysaccharide deacetylase
M1S52_06860	COG1215	transferase activity, transferring glycosyl groups
M1S52_06865	COG3658	cytochrome
M1S52_06875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S52_06890	COG0583	DNA-binding transcription factor activity
M1S52_06910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S52_06915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S52_06930	COG1960	acyl-CoA dehydrogenase activity
M1S52_06935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S52_06940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S52_06965	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S52_06970	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S52_06980	COG2205	protein histidine kinase activity
M1S52_06985	COG0745	RESPONSE REGULATOR receiver
M1S52_06990	COG0174	glutamine synthetase
M1S52_07010	COG0729	surface antigen
M1S52_07035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S52_07040	COG2814	Major facilitator Superfamily
M1S52_07055	COG0583	DNA-binding transcription factor activity
M1S52_07070	COG1187	pseudouridine synthase activity
M1S52_07090	COG0802	atpase or kinase
M1S52_07095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S52_07105	COG1923	regulation of RNA biosynthetic process
M1S52_07110	COG0697	spore germination
M1S52_07125	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S52_07135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S52_07140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S52_07140	COG0519	Catalyzes the synthesis of GMP from XMP
M1S52_07145	COG4302	ethanolamine ammonia-lyase activity
M1S52_07150	COG4303	Ethanolamine ammonia lyase large subunit
M1S52_07155	COG0531	amino acid
M1S52_07180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S52_07220	COG0308	aminopeptidase N
M1S52_07230	COG4221	oxidoreductase activity
M1S52_07240	COG1605	Chorismate mutase
M1S52_07260	COG1309	transcriptional regulator
M1S52_07270	COG0668	transmembrane transport
M1S52_07305	COG4773	Receptor
M1S52_07325	COG0488	(ABC) transporter
M1S52_07330	COG0589	response to stress
M1S52_07355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S52_07365	COG3135	benzoate transporter
M1S52_07370	COG1522	sequence-specific DNA binding
M1S52_07380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S52_07385	COG0583	DNA-binding transcription factor activity
M1S52_07395	COG0183	Belongs to the thiolase family
M1S52_07405	COG2030	dehydratase
M1S52_07410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S52_07425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S52_07435	COG0824	Thioesterase
M1S52_07440	COG1454	alcohol dehydrogenase
M1S52_07450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S52_07470	COG0069	glutamate synthase activity
M1S52_07655	COG5410	chromosome segregation
M1S52_07845	COG2814	Major facilitator Superfamily
M1S52_07860	COG0511	ligase activity, forming carbon-carbon bonds
M1S52_07885	COG0745	RESPONSE REGULATOR receiver
M1S52_07895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S52_07895	COG2146	nitrite reductase [NAD(P)H] activity
M1S52_07900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S52_07905	COG0243	molybdopterin cofactor binding
M1S52_07915	COG0243	molybdopterin cofactor binding
M1S52_07920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S52_07935	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S52_07935	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S52_07940	COG0303	'Molybdopterin
M1S52_07950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S52_07955	COG0697	spore germination
M1S52_07975	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S52_07980	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S52_08035	COG2204	response regulator
M1S52_08040	COG3852	Histidine kinase
M1S52_08060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S52_08065	COG0575	Belongs to the CDS family
M1S52_08100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S52_08115	COG2137	regulation of response to DNA damage stimulus
M1S52_08125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S52_08130	COG1011	Hydrolase
M1S52_08155	COG1522	sequence-specific DNA binding
M1S52_08165	COG1113	amino acid transport
M1S52_08185	COG0659	secondary active sulfate transmembrane transporter activity
M1S52_08190	COG2135	peptidase activity
M1S52_08205	COG3300	MHYT domain
M1S52_08205	COG5001	Diguanylate cyclase
M1S52_08225	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S52_08225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S52_08225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S52_08230	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S52_08235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S52_08235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S52_08265	COG0024	Methionine aminopeptidase
M1S52_08270	COG0583	DNA-binding transcription factor activity
M1S52_08280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S52_08285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S52_08290	COG0516	GMP reductase activity
M1S52_08290	COG0517	IMP dehydrogenase activity
M1S52_08315	COG0552	protein localization to endoplasmic reticulum
M1S52_08325	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S52_08340	COG4890	Cyd operon protein YbgT
M1S52_08345	COG1294	oxidase, subunit
M1S52_08360	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S52_08370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S52_08375	COG4774	siderophore transport
M1S52_08390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S52_08395	COG0569	domain protein
M1S52_08400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S52_08430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S52_08435	COG0542	response to heat
M1S52_08460	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S52_08460	COG1902	pentaerythritol trinitrate reductase activity
M1S52_08505	COG2323	membrane
M1S52_08510	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S52_08520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S52_08525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S52_08530	COG0183	Belongs to the thiolase family
M1S52_08535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S52_08540	COG0596	Alpha beta hydrolase
M1S52_08545	COG2271	Major facilitator Superfamily
M1S52_08550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S52_08555	COG3485	protocatechuate 3,4-dioxygenase
M1S52_08560	COG3485	protocatechuate 3,4-dioxygenase
M1S52_08565	COG0710	3-dehydroquinate dehydratase activity
M1S52_08570	COG3420	alginic acid biosynthetic process
M1S52_08575	COG3659	wide pore channel activity
M1S52_08580	COG4993	Dehydrogenase
M1S52_08590	COG2391	methyltransferase activity
M1S52_08605	COG1414	Transcriptional regulator
M1S52_08610	COG0583	DNA-binding transcription factor activity
M1S52_08615	COG1960	acyl-CoA dehydrogenase activity
M1S52_08640	COG2814	Major facilitator Superfamily
M1S52_08650	COG0154	amidase activity
M1S52_08670	COG4638	Rieske (2fe-2S)
M1S52_08680	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_08690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S52_08700	COG3733	amine oxidase
M1S52_08710	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_08720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S52_08725	COG0183	Belongs to the thiolase family
M1S52_08730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S52_08735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S52_08745	COG4829	muconolactone delta-isomerase
M1S52_08750	COG4948	Mandelate Racemase Muconate Lactonizing
M1S52_08765	COG2186	Transcriptional regulator
M1S52_08785	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_08805	COG1960	acyl-CoA dehydrogenase activity
M1S52_08810	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_08815	COG3829	transcription factor binding
M1S52_08825	COG3162	membrane
M1S52_08840	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_08855	COG0753	catalase activity
M1S52_08875	COG1846	Transcriptional regulator
M1S52_08880	COG1902	pentaerythritol trinitrate reductase activity
M1S52_08880	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S52_08890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S52_08920	COG1309	transcriptional regulator
M1S52_08930	COG1335	isochorismatase
M1S52_08935	COG0583	DNA-binding transcription factor activity
M1S52_08945	COG0475	glutathione-regulated potassium exporter activity
M1S52_08945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S52_08955	COG1473	amidohydrolase
M1S52_08965	COG2831	hemolysin activation secretion protein
M1S52_09000	COG2188	Transcriptional regulator
M1S52_09015	COG0583	DNA-binding transcription factor activity
M1S52_09045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S52_09075	COG1566	PFAM secretion protein HlyD family protein
M1S52_09090	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_09095	COG0129	dihydroxy-acid dehydratase activity
M1S52_09105	COG0583	DNA-binding transcription factor activity
M1S52_09110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S52_09120	COG2084	Dehydrogenase
M1S52_09125	COG2207	Transcriptional regulator
M1S52_09140	COG1064	alcohol dehydrogenase
M1S52_09150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S52_09155	COG1120	ATPase activity
M1S52_09175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S52_09295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S52_09345	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_09360	COG2207	Transcriptional regulator
M1S52_09370	COG2205	protein histidine kinase activity
M1S52_09375	COG0745	RESPONSE REGULATOR receiver
M1S52_09380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S52_09385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S52_09390	COG1538	Outer membrane efflux protein
M1S52_09400	COG2072	flavoprotein involved in K transport
M1S52_09420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S52_09440	COG3539	Fimbrial protein
M1S52_09470	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S52_09480	COG0753	catalase activity
M1S52_09495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S52_09555	COG3433	isochorismatase activity
M1S52_09555	COG1535	isochorismatase
M1S52_09560	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_09565	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S52_09570	COG4149	molybdate abc transporter
M1S52_09575	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S52_09585	COG4638	Rieske (2fe-2S)
M1S52_09590	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S52_09595	COG0543	2 iron, 2 sulfur cluster binding
M1S52_09595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S52_09620	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_09635	COG2207	Transcriptional regulator
M1S52_09645	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_09650	COG2610	gluconate transmembrane transporter activity
M1S52_09660	COG0583	DNA-binding transcription factor activity
M1S52_09670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S52_09675	COG2031	fatty acid transporter
M1S52_09680	COG0183	Belongs to the thiolase family
M1S52_09685	COG0583	DNA-binding transcription factor activity
M1S52_09690	COG0583	DNA-binding transcription factor activity
M1S52_09705	COG1027	Aspartate ammonia-lyase
M1S52_09715	COG0477	Major facilitator Superfamily
M1S52_09735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S52_09740	COG4521	taurine ABC transporter
M1S52_09755	COG2188	Transcriptional regulator
M1S52_09765	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S52_09770	COG1733	regulation of RNA biosynthetic process
M1S52_09775	COG2207	Transcriptional regulator
M1S52_09775	COG3708	Transcriptional regulator
M1S52_09790	COG0730	response to heat
M1S52_09805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S52_09805	COG3453	Protein conserved in bacteria
M1S52_09815	COG3781	membrane
M1S52_09820	COG1063	alcohol dehydrogenase
M1S52_09830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S52_09835	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S52_09840	COG0022	dehydrogenase e1 component
M1S52_09845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S52_09850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S52_09865	COG3706	GGDEF domain
M1S52_09880	COG0133	tryptophan synthase activity
M1S52_09890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S52_09925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S52_09950	COG2226	methyltransferase
M1S52_10005	COG0842	Transport permease protein
M1S52_10010	COG0842	Transport permease protein
M1S52_10015	COG1131	(ABC) transporter
M1S52_10030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S52_10035	COG4773	Receptor
M1S52_10055	COG0730	response to heat
M1S52_10060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S52_10080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S52_10095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S52_10180	COG0589	response to stress
M1S52_10185	COG0659	secondary active sulfate transmembrane transporter activity
M1S52_10200	COG4264	IucA IucC family
M1S52_10225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S52_10240	COG1960	acyl-CoA dehydrogenase activity
M1S52_10245	COG1960	acyl-CoA dehydrogenase activity
M1S52_10250	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S52_10255	COG2207	Transcriptional regulator
M1S52_10260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S52_10265	COG0776	regulation of translation
M1S52_10290	COG0822	iron-sulfur transferase activity
M1S52_10295	COG0316	Belongs to the HesB IscA family
M1S52_10325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S52_10345	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S52_10350	COG0702	epimerase
M1S52_10385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S52_10395	COG0339	signal peptide processing
M1S52_10445	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S52_10450	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S52_10455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S52_10485	COG0776	regulation of translation
M1S52_10550	COG0084	hydrolase, TatD family'
M1S52_10570	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S52_10575	COG1132	(ABC) transporter
M1S52_10585	COG0811	peptide transport
M1S52_10590	COG1475	DNA binding
M1S52_10595	COG1192	Involved in chromosome partitioning
M1S52_10605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S52_10620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S52_10625	COG0191	fructose-bisphosphate aldolase activity
M1S52_10645	COG0424	maF-like protein
M1S52_10650	COG2850	peptidyl-arginine hydroxylation
M1S52_10660	COG0640	Transcriptional regulator
M1S52_10670	COG3619	membrane
M1S52_10675	COG3122	Protein conserved in bacteria
M1S52_10680	COG1132	(ABC) transporter
M1S52_10700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S52_10705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S52_10715	COG0506	proline dehydrogenase activity
M1S52_10715	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S52_10715	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S52_10720	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S52_10735	COG3698	Phosphodiester glycosidase
M1S52_10745	COG2353	YceI-like domain
M1S52_10755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S52_10805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S52_10805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S52_10830	COG3539	Fimbrial protein
M1S52_10835	COG3121	Chaperone
M1S52_10860	COG0697	spore germination
M1S52_10870	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S52_10880	COG0583	DNA-binding transcription factor activity
M1S52_10900	COG1309	transcriptional regulator
M1S52_10915	COG1522	sequence-specific DNA binding
M1S52_10925	COG1126	abc transporter atp-binding protein
M1S52_10930	COG0765	amino acid transport
M1S52_10935	COG0765	amino acid transport
M1S52_10965	COG1464	Belongs to the NlpA lipoprotein family
M1S52_10975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S52_10980	COG2011	ABC-type metal ion transport system permease component
M1S52_10985	COG0012	GTP binding
M1S52_11010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S52_11050	COG0386	Belongs to the glutathione peroxidase family
M1S52_11060	COG0436	Aminotransferase
M1S52_11100	COG3634	alkyl hydroperoxide reductase activity
M1S52_11115	COG0583	DNA-binding transcription factor activity
M1S52_11120	COG0798	PFAM Bile acid sodium symporter
M1S52_11125	COG0640	Transcriptional regulator
M1S52_11140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S52_11150	COG0583	DNA-binding transcription factor activity
M1S52_11160	COG1953	Uracil, thiamine, allantoin
M1S52_11170	COG2175	clavaminate synthase activity
M1S52_11175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S52_11180	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S52_11185	COG4521	taurine ABC transporter
M1S52_11195	COG0477	Major facilitator Superfamily
M1S52_11220	COG1271	oxidase subunit
M1S52_11225	COG1294	oxidase, subunit
M1S52_11235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S52_11255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S52_11275	COG3052	prosthetic group binding
M1S52_11280	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S52_11290	COG2814	Major facilitator Superfamily
M1S52_11310	COG1346	cytolysis
M1S52_11325	COG0625	glutathione transferase activity
M1S52_11330	COG0625	glutathione transferase activity
M1S52_11335	COG0583	DNA-binding transcription factor activity
M1S52_11350	COG1045	serine acetyltransferase
M1S52_11355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S52_11360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S52_11370	COG1280	lysine exporter protein (LysE YggA)
M1S52_11385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S52_11390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S52_11395	COG1126	abc transporter atp-binding protein
M1S52_11400	COG0765	amino acid transport
M1S52_11405	COG0765	amino acid transport
M1S52_11425	COG0784	Response regulator, receiver
M1S52_11425	COG2205	protein histidine kinase activity
M1S52_11445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S52_11465	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_11515	COG0583	DNA-binding transcription factor activity
M1S52_11535	COG0318	PFAM AMP-dependent synthetase and ligase
M1S52_11540	COG1309	transcriptional regulator
M1S52_11545	COG1960	acyl-CoA dehydrogenase activity
M1S52_11550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S52_11555	COG1024	Enoyl-CoA hydratase
M1S52_11560	COG4770	biotin carboxylase activity
M1S52_11570	COG0583	DNA-binding transcription factor activity
M1S52_11585	COG1960	acyl-CoA dehydrogenase activity
M1S52_11595	COG2814	Major facilitator Superfamily
M1S52_11605	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S52_11610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S52_11615	COG2814	Major facilitator Superfamily
M1S52_11620	COG1960	acyl-CoA dehydrogenase activity
M1S52_11625	COG1024	Enoyl-CoA hydratase
M1S52_11630	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_11635	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S52_11640	COG0183	Belongs to the thiolase family
M1S52_11650	COG2814	Major facilitator Superfamily
M1S52_11660	COG1024	Enoyl-CoA hydratase
M1S52_11675	COG1960	acyl-CoA dehydrogenase activity
M1S52_11680	COG2814	Major facilitator Superfamily
M1S52_11685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S52_11690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S52_11705	COG3842	ATPase activity
M1S52_11710	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S52_11720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S52_11725	COG1414	Transcriptional regulator
M1S52_11735	COG0583	DNA-binding transcription factor activity
M1S52_11740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S52_11745	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_11755	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S52_11765	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_11770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S52_11775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S52_11780	COG2267	carboxylic ester hydrolase activity
M1S52_11800	COG3038	cytochrome b561
M1S52_11805	COG0753	catalase activity
M1S52_11840	COG2050	protein possibly involved in aromatic compounds catabolism
M1S52_11850	COG3327	negative regulation of DNA-templated transcription, initiation
M1S52_11855	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S52_11860	COG0183	Belongs to the thiolase family
M1S52_11865	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S52_11870	COG1024	Enoyl-CoA hydratase
M1S52_11875	COG1024	Enoyl-CoA hydratase
M1S52_11880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S52_11885	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S52_11890	COG3396	Phenylacetate-CoA oxygenase
M1S52_11895	COG3460	Phenylacetate-CoA oxygenase
M1S52_11900	COG3396	Phenylacetate-CoA oxygenase
M1S52_11905	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_11905	COG2030	dehydratase
M1S52_11910	COG1760	l-serine dehydratase
M1S52_11915	COG0531	amino acid
M1S52_11920	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_11935	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S52_11945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S52_11965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S52_11975	COG0789	Transcriptional regulator
M1S52_11990	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S52_12005	COG2807	transmembrane transport
M1S52_12010	COG0590	tRNA wobble adenosine to inosine editing
M1S52_12100	COG3328	transposase activity
M1S52_12135	COG1116	anion transmembrane transporter activity
M1S52_12140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S52_12150	COG0864	Transcriptional regulator
M1S52_12170	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S52_12175	COG0439	Biotin carboxylase
M1S52_12190	COG1063	alcohol dehydrogenase
M1S52_12200	COG1309	transcriptional regulator
M1S52_12220	COG0038	chloride channel
M1S52_12225	COG4770	biotin carboxylase activity
M1S52_12245	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S52_12250	COG0583	DNA-binding transcription factor activity
M1S52_12300	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S52_12320	COG2814	Major facilitator Superfamily
M1S52_12335	COG1560	Kdo2-lipid A biosynthetic process
M1S52_12345	COG5006	permease, DMT superfamily
M1S52_12350	COG1522	sequence-specific DNA binding
M1S52_12365	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S52_12375	COG4122	O-methyltransferase activity
M1S52_12405	COG1538	Outer membrane efflux protein
M1S52_12410	COG1137	ATPase activity
M1S52_12415	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S52_12425	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S52_12430	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S52_12430	COG0517	IMP dehydrogenase activity
M1S52_12465	COG2814	Major facilitator Superfamily
M1S52_12500	COG1278	Cold shock
M1S52_12505	COG1280	lysine exporter protein (LysE YggA)
M1S52_12535	COG1570	exodeoxyribonuclease VII activity
M1S52_12585	COG0583	DNA-binding transcription factor activity
M1S52_12595	COG4638	Rieske (2fe-2S)
M1S52_12600	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S52_12605	COG0633	Ferredoxin
M1S52_12605	COG0543	2 iron, 2 sulfur cluster binding
M1S52_12610	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_12615	COG3135	benzoate transporter
M1S52_12620	COG2814	Major facilitator Superfamily
M1S52_12635	COG1643	Atp-dependent helicase
M1S52_12640	COG0450	alkyl hydroperoxide reductase
M1S52_12650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S52_12680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S52_12685	COG0625	glutathione transferase activity
M1S52_12695	COG2885	chlorophyll binding
M1S52_12730	COG0542	response to heat
M1S52_12745	COG1765	OsmC-like protein
M1S52_12765	COG0667	Aldo Keto reductase
M1S52_12780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S52_12790	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S52_12800	COG0527	aspartate kinase activity
M1S52_12810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S52_12820	COG3038	cytochrome b561
M1S52_12825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M1S52_12830	COG2252	PERMEase
M1S52_12840	COG2072	flavoprotein involved in K transport
M1S52_12855	COG1741	Belongs to the pirin family
M1S52_12860	COG1309	transcriptional regulator
M1S52_12870	COG0300	oxidoreductase activity
M1S52_12975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M1S52_13025	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_13045	COG0531	amino acid
M1S52_13055	COG1113	amino acid transport
M1S52_13095	COG3209	COG3209 Rhs family protein
M1S52_13125	COG4269	membrane
M1S52_13140	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S52_13140	COG1902	pentaerythritol trinitrate reductase activity
M1S52_13150	COG2203	Gaf domain
M1S52_13150	COG3706	GGDEF domain
M1S52_13150	COG4251	negative regulation of phosphorylation
M1S52_13150	COG5001	Diguanylate cyclase
M1S52_13160	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S52_13180	COG4172	Belongs to the ABC transporter superfamily
M1S52_13185	COG4239	(ABC) transporter, permease
M1S52_13190	COG4174	ABC transporter (Permease)
M1S52_13200	COG0741	lytic transglycosylase activity
M1S52_13200	COG1388	LysM domain
M1S52_13200	COG0741	lytic transglycosylase activity
M1S52_13200	COG1388	LysM domain
M1S52_13205	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S52_13245	COG0583	DNA-binding transcription factor activity
M1S52_13250	COG1279	arginine transmembrane transporter activity
M1S52_13270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S52_13275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S52_13280	COG0006	proline dipeptidase activity
M1S52_13320	COG2194	sulfuric ester hydrolase activity
M1S52_13370	COG0739	heme binding
M1S52_13695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S52_13720	COG3384	dioxygenase
M1S52_13730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S52_13735	COG2878	Part of a membrane complex involved in electron transport
M1S52_13740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S52_13765	COG0768	penicillin binding
M1S52_13770	COG0742	ribosomal rna small subunit methyltransferase
M1S52_13785	COG0830	nickel cation binding
M1S52_13795	COG0804	urea catabolic process
M1S52_13835	COG1253	flavin adenine dinucleotide binding
M1S52_13840	COG2851	Citrate transporter
M1S52_13890	COG1773	rubredoxin
M1S52_13895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S52_13905	COG0583	DNA-binding transcription factor activity
M1S52_13930	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S52_13935	COG4181	ATPase activity
M1S52_13980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S52_14000	COG0306	phosphate transporter
M1S52_14010	COG3958	Transketolase
M1S52_14015	COG3959	Transketolase, thiamine diphosphate binding domain
M1S52_14020	COG2271	Major facilitator Superfamily
M1S52_14025	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_14030	COG0583	DNA-binding transcription factor activity
M1S52_14045	COG2223	nitrite transmembrane transporter activity
M1S52_14050	COG2207	Transcriptional regulator
M1S52_14055	COG2066	Belongs to the glutaminase family
M1S52_14060	COG0242	peptide deformylase activity
M1S52_14065	COG0477	Major facilitator Superfamily
M1S52_14075	COG0028	Belongs to the TPP enzyme family
M1S52_14090	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_14095	COG2267	carboxylic ester hydrolase activity
M1S52_14105	COG2271	Major facilitator Superfamily
M1S52_14110	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S52_14120	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_14140	COG1414	Transcriptional regulator
M1S52_14155	COG1024	Enoyl-CoA hydratase
M1S52_14165	COG1215	transferase activity, transferring glycosyl groups
M1S52_14170	COG0726	polysaccharide deacetylase
M1S52_14170	COG1649	PFAM Uncharacterised BCR, COG1649
M1S52_14180	COG4681	YaeQ
M1S52_14190	COG0523	cobalamin synthesis protein
M1S52_14200	COG1607	acyl-coa hydrolase
M1S52_14210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S52_14215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S52_14220	COG1309	transcriptional regulator
M1S52_14245	COG2040	homocysteine
M1S52_14250	COG0531	amino acid
M1S52_14275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S52_14280	COG0477	Major facilitator Superfamily
M1S52_14400	COG0592	DNA-directed DNA polymerase activity
M1S52_14440	COG2026	Addiction module toxin, RelE StbE family
M1S52_14590	COG3755	Protein conserved in bacteria
M1S52_14635	COG1484	DNA-dependent DNA replication
M1S52_14725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S52_14795	COG0405	Gamma-glutamyltransferase
M1S52_14800	COG2814	Major facilitator Superfamily
M1S52_14810	COG2050	protein possibly involved in aromatic compounds catabolism
M1S52_14825	COG1090	epimerase
M1S52_14845	COG0420	3'-5' exonuclease activity
M1S52_14870	COG0735	belongs to the Fur family
M1S52_14875	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S52_14895	COG0121	glutamine amidotransferase
M1S52_14910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S52_14920	COG0210	DNA helicase
M1S52_14925	COG2885	chlorophyll binding
M1S52_14930	COG0204	Acyl-transferase
M1S52_14945	COG2894	cell division
M1S52_14970	COG1280	lysine exporter protein (LysE YggA)
M1S52_14975	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S52_14975	COG1674	ftsk spoiiie
M1S52_14980	COG0492	ferredoxin-NADP+ reductase activity
M1S52_14985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S52_14995	COG0456	acetyltransferase
M1S52_15040	COG1981	membrane
M1S52_15055	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S52_15055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S52_15075	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_15085	COG0657	acetylesterase activity
M1S52_15095	COG0473	3-isopropylmalate dehydrogenase activity
M1S52_15100	COG0583	DNA-binding transcription factor activity
M1S52_15120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S52_15145	COG0564	pseudouridine synthase activity
M1S52_15155	COG0358	DNA primase activity
M1S52_15170	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S52_15200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S52_15270	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S52_15275	COG3101	peptidyl-lysine hydroxylation
M1S52_15280	COG0009	L-threonylcarbamoyladenylate synthase
M1S52_15285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S52_15290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S52_15305	COG4106	trans-aconitate 2-methyltransferase activity
M1S52_15320	COG0596	Alpha beta hydrolase
M1S52_15320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S52_15320	COG2226	methyltransferase
M1S52_15325	COG1877	trehalose-phosphatase activity
M1S52_15330	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S52_15335	COG2223	nitrite transmembrane transporter activity
M1S52_15355	COG1196	nuclear chromosome segregation
M1S52_15365	COG0730	response to heat
M1S52_15380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S52_15390	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S52_15440	COG0489	protein tyrosine kinase activity
M1S52_15450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S52_15450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S52_15480	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S52_15485	COG2081	HI0933 family
M1S52_15495	COG0668	transmembrane transport
M1S52_15515	COG0583	DNA-binding transcription factor activity
M1S52_15535	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S52_15540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S52_15570	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S52_15610	COG0745	RESPONSE REGULATOR receiver
M1S52_15630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S52_15640	COG2205	protein histidine kinase activity
M1S52_15710	COG4993	Dehydrogenase
M1S52_15735	COG0384	phenazine biosynthesis protein PhzF
M1S52_15760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S52_15775	COG0583	DNA-binding transcription factor activity
M1S52_15805	COG0583	DNA-binding transcription factor activity
M1S52_15820	COG0583	DNA-binding transcription factor activity
M1S52_15825	COG1053	succinate dehydrogenase
M1S52_15835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S52_15840	COG2814	Major facilitator Superfamily
M1S52_15845	COG1960	acyl-CoA dehydrogenase activity
M1S52_15850	COG0583	DNA-binding transcription factor activity
M1S52_15855	COG1063	alcohol dehydrogenase
M1S52_15885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S52_15890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S52_15895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S52_15910	COG3667	copper resistance
M1S52_15915	COG2132	Multicopper oxidase
M1S52_15925	COG0561	phosphatase activity
M1S52_15930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S52_15955	COG1214	PFAM Peptidase M22, glycoprotease
M1S52_16005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S52_16015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S52_16020	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S52_16025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S52_16085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S52_16095	COG1846	Transcriptional regulator
M1S52_16100	COG1764	response to oxidative stress
M1S52_16140	COG0037	tRNA processing
M1S52_16150	COG0248	Ppx GppA phosphatase
M1S52_16180	COG0072	phenylalanine-tRNA ligase activity
M1S52_16225	COG1238	metal cluster binding
M1S52_16230	COG0625	glutathione transferase activity
M1S52_16245	COG0318	PFAM AMP-dependent synthetase and ligase
M1S52_16250	COG3028	Belongs to the UPF0307 family
M1S52_16255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S52_16275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S52_16280	COG0617	tRNA 3'-terminal CCA addition
M1S52_16285	COG1555	photosystem II stabilization
M1S52_16290	COG3956	TIGRFAM MazG family protein
M1S52_16300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S52_16320	COG0784	Response regulator, receiver
M1S52_16320	COG2205	protein histidine kinase activity
M1S52_16320	COG5002	protein histidine kinase activity
M1S52_16325	COG1024	Enoyl-CoA hydratase
M1S52_16330	COG2084	Dehydrogenase
M1S52_16335	COG3622	Belongs to the hyi family
M1S52_16365	COG0697	spore germination
M1S52_16375	COG2814	Major facilitator Superfamily
M1S52_16380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S52_16390	COG0583	DNA-binding transcription factor activity
M1S52_16400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S52_16430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S52_16460	COG0440	acetolactate synthase activity
M1S52_16465	COG0028	Belongs to the TPP enzyme family
M1S52_16490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S52_16495	COG0577	efflux transmembrane transporter activity
M1S52_16495	COG1136	(ABC) transporter
M1S52_16500	COG1538	Outer membrane efflux protein
M1S52_16515	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S52_16520	COG1162	GTPase activity
M1S52_16530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S52_16550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S52_16555	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_16595	COG2986	histidine ammonia-lyase
M1S52_16610	COG0318	PFAM AMP-dependent synthetase and ligase
M1S52_16620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S52_16665	COG1426	Protein conserved in bacteria
M1S52_16700	COG0793	Belongs to the peptidase S41A family
M1S52_16715	COG2267	carboxylic ester hydrolase activity
M1S52_16725	COG1012	belongs to the aldehyde dehydrogenase family
M1S52_16730	COG3265	gluconokinase activity
M1S52_16740	COG0800	Aldolase
M1S52_16750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S52_16755	COG0857	belongs to the CobB CobQ family
M1S52_16755	COG0280	phosphate acetyltransferase
M1S52_16760	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S52_16760	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S52_16780	COG0740	serine-type endopeptidase activity
M1S52_16790	COG4774	siderophore transport
M1S52_16800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S52_16810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S52_16810	COG2813	Specifically methylates the guanine in position
M1S52_16910	COG0788	formyltetrahydrofolate deformylase activity
M1S52_16935	COG4651	solute:proton antiporter activity
M1S52_16935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S52_16955	COG0724	RNA recognition motif
M1S52_16960	COG0210	DNA helicase
M1S52_16985	COG1733	regulation of RNA biosynthetic process
M1S52_16995	COG2900	Belongs to the SlyX family
M1S52_17000	COG0488	(ABC) transporter
M1S52_17005	COG1280	lysine exporter protein (LysE YggA)
M1S52_17010	COG1560	Kdo2-lipid A biosynthetic process
M1S52_17020	COG1301	dicarboxylic acid transport
M1S52_17075	COG0473	3-isopropylmalate dehydrogenase activity
M1S52_17140	COG0583	DNA-binding transcription factor activity
M1S52_17150	COG0625	glutathione transferase activity
M1S52_17155	COG2378	regulation of single-species biofilm formation
M1S52_17160	COG0546	phosphoglycolate phosphatase activity
M1S52_17170	COG1530	ribonuclease E activity
M1S52_17175	COG0318	PFAM AMP-dependent synthetase and ligase
M1S52_17190	COG0583	DNA-binding transcription factor activity
M1S52_17195	COG4221	oxidoreductase activity
M1S52_17200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S52_17210	COG0534	Mate efflux family protein
M1S52_17225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S52_17265	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S52_17270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S52_17285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S52_17295	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S52_17295	COG0644	oxidoreductase
M1S52_17300	COG0425	Belongs to the sulfur carrier protein TusA family
M1S52_17305	COG4535	Mg2 and Co2 transporter CorC
M1S52_17315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S52_17335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S52_17340	COG0475	glutathione-regulated potassium exporter activity
M1S52_17340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S52_17345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S52_17355	COG0484	heat shock protein binding
M1S52_17360	COG0789	Transcriptional regulator
M1S52_17365	COG0598	Magnesium transport protein CorA
M1S52_17380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S52_17385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S52_17390	COG1074	ATP-dependent DNA helicase activity
M1S52_17395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S52_17415	COG2226	methyltransferase
M1S52_17430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S52_17435	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S52_17450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S52_17450	COG2111	Na H antiporter
M1S52_17455	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S52_17460	COG0651	ATP synthesis coupled electron transport
M1S52_17465	COG1863	multisubunit Na H antiporter MnhE subunit
M1S52_17470	COG2212	antiporter activity
M1S52_17475	COG1320	monovalent cation:proton antiporter activity
M1S52_17490	COG0195	Participates in both transcription termination and antitermination
M1S52_17540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S52_17545	COG0237	dephospho-CoA kinase activity
M1S52_17555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S52_17570	COG0497	DNA recombination
M1S52_17580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S52_17610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S52_17610	COG2169	Transcriptional regulator
M1S52_17615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S52_17680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S52_17695	COG0326	Molecular chaperone. Has ATPase activity
M1S52_17710	COG2056	Na+-H+ antiporter family
M1S52_17715	COG0596	Alpha beta hydrolase
M1S52_17810	COG0546	phosphoglycolate phosphatase activity
M1S52_17815	COG1716	ATPase activity
M1S52_17860	COG0181	hydroxymethylbilane synthase activity
M1S52_17870	COG3275	phosphorelay sensor kinase activity
M1S52_17890	COG1538	Outer membrane efflux protein
M1S52_17895	COG0697	spore germination
M1S52_17920	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S52_17925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S52_17930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S52_17935	COG0772	Belongs to the SEDS family
M1S52_17960	COG4974	Belongs to the 'phage' integrase family
M1S52_17965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S52_17975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S52_17985	COG2197	response regulator
M1S52_18000	COG0793	Belongs to the peptidase S41A family
M1S52_18005	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S52_18010	COG0795	lipopolysaccharide-transporting ATPase activity
M1S52_18050	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S52_18050	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S52_18060	COG0004	ammonium transporteR
M1S52_18065	COG0347	Belongs to the P(II) protein family
M1S52_18125	COG0659	secondary active sulfate transmembrane transporter activity
M1S52_18130	COG0589	response to stress
M1S52_18175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S52_18185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S52_18205	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S52_18220	COG0318	PFAM AMP-dependent synthetase and ligase
M1S52_18230	COG0477	Major facilitator Superfamily
M1S52_18235	COG2860	membrane
M1S52_18245	COG1253	flavin adenine dinucleotide binding
M1S52_18265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S52_18305	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S52_18385	COG0758	DNA mediated transformation
M1S52_18395	COG0697	spore germination
M1S52_18400	COG1309	transcriptional regulator
M1S52_18415	COG0386	Belongs to the glutathione peroxidase family
M1S52_18480	COG1121	(ABC) transporter
M1S52_18485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S52_18490	COG1280	lysine exporter protein (LysE YggA)
M1S52_18495	COG2837	iron assimilation
M1S52_18505	COG0281	malic enzyme
M1S52_18550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S52_18550	COG0519	Catalyzes the synthesis of GMP from XMP
M1S52_18555	COG4399	Belongs to the UPF0754 family
M1S52_18560	COG2259	Doxx family
M1S52_18565	COG0586	Pfam SNARE associated Golgi protein
M1S52_18580	COG1192	Involved in chromosome partitioning
M1S52_18590	COG0271	Belongs to the BolA IbaG family
M1S52_18610	COG2267	carboxylic ester hydrolase activity
M1S52_18630	COG3321	synthase
M1S52_18630	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S52_18630	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S52_18630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S52_18635	COG1960	acyl-CoA dehydrogenase activity
M1S52_18645	COG2197	response regulator
M1S52_18655	COG3916	Acyl-homoserine-lactone synthase
M1S52_18660	COG0477	Major facilitator Superfamily
M1S52_18665	COG1024	Enoyl-CoA hydratase
M1S52_18670	COG1024	Enoyl-CoA hydratase
M1S52_18675	COG1960	acyl-CoA dehydrogenase activity
M1S52_18680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S52_18700	COG1113	amino acid transport
M1S52_18705	COG1113	amino acid transport
M1S52_18710	COG0251	oxidation-reduction process
M1S52_18750	COG0564	pseudouridine synthase activity
M1S52_18810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S52_18825	COG1802	Transcriptional regulator
M1S52_18835	COG1448	Aminotransferase
M1S52_18840	COG0277	FAD linked oxidase domain protein
M1S52_18850	COG2186	Transcriptional regulator
M1S52_18860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S52_18865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S52_18880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S52_18885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S52_18890	COG1216	Glycosyl transferase, family 2
M1S52_18920	COG2089	acid synthase
M1S52_18935	COG1083	cytidylyl-transferase
M1S52_18940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S52_18945	COG1086	Polysaccharide biosynthesis protein
M1S52_18950	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S52_18955	COG1596	polysaccharide export
M1S52_18980	COG0728	peptidoglycan biosynthetic process
M1S52_18985	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S52_19045	COG0546	phosphoglycolate phosphatase activity
M1S52_19050	COG1028	Short-chain dehydrogenase reductase Sdr
M1S52_19070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S52_19075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S52_19080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S52_19085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S52_19090	COG1116	anion transmembrane transporter activity
M1S52_19095	COG1309	transcriptional regulator
M1S52_19100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S52_19110	COG0196	riboflavin kinase activity
M1S52_19115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S52_19125	COG1047	Peptidyl-prolyl cis-trans
M1S52_19165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S52_19170	COG0657	acetylesterase activity
M1S52_19190	COG0583	DNA-binding transcription factor activity
M1S52_19220	COG2951	lytic endotransglycosylase activity
M1S52_19225	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S52_19240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S52_19250	COG0671	phosphoesterase, PA-phosphatase related
M1S52_19255	COG0861	Integral membrane protein TerC family
M1S52_19265	COG0754	glutathionylspermidine amidase activity
M1S52_19275	COG0402	S-adenosylhomocysteine deaminase activity
M1S52_19290	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S52_19295	COG1230	cation diffusion facilitator family transporter
M1S52_19310	COG0706	membrane insertase activity
M1S52_19375	COG0358	DNA primase activity
M1S52_19565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S52_19585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S52_19665	COG1063	alcohol dehydrogenase
M1S52_19690	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M1S52_19705	COG1979	alcohol dehydrogenase
M1S52_19715	COG1902	pentaerythritol trinitrate reductase activity
M1S52_19725	COG1309	transcriptional regulator
M1S52_19770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S52_19810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S52_19815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S52_19815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M1S52_19865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S52_19865	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M1S52_19880	COG0587	DNA-directed DNA polymerase activity
M1S52_19925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily