locus-tag	class	description
M1S56_00010	COG0592	DNA-directed DNA polymerase activity
M1S56_00020	COG0187	DNA topoisomerase II activity
M1S56_00030	COG0586	Pfam SNARE associated Golgi protein
M1S56_00035	COG0488	(ABC) transporter
M1S56_00060	COG0596	Alpha beta hydrolase
M1S56_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M1S56_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M1S56_00110	COG0733	neurotransmitter:sodium symporter activity
M1S56_00150	COG2233	PERMEase
M1S56_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S56_00200	COG2814	Major facilitator Superfamily
M1S56_00205	COG0656	L-ascorbic acid biosynthetic process
M1S56_00210	COG0583	DNA-binding transcription factor activity
M1S56_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S56_00230	COG1064	alcohol dehydrogenase
M1S56_00235	COG2818	Glycosylase
M1S56_00250	COG1194	a g-specific adenine glycosylase
M1S56_00270	COG2983	Belongs to the UPF0260 family
M1S56_00275	COG2133	pyrroloquinoline quinone binding
M1S56_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M1S56_00285	COG2116	formate transmembrane transporter activity
M1S56_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S56_00310	COG1335	isochorismatase
M1S56_00315	COG0385	Bile acid
M1S56_00320	COG0534	Mate efflux family protein
M1S56_00325	COG1683	Conserved Protein
M1S56_00345	COG0625	glutathione transferase activity
M1S56_00355	COG1113	amino acid transport
M1S56_00365	COG0523	cobalamin synthesis protein
M1S56_00375	COG2188	Transcriptional regulator
M1S56_00405	COG0010	Belongs to the arginase family
M1S56_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S56_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M1S56_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M1S56_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M1S56_00540	COG0534	Mate efflux family protein
M1S56_00545	COG0436	Aminotransferase
M1S56_00550	COG2733	membrane
M1S56_00565	COG2918	glutathione biosynthetic process
M1S56_00580	COG0791	NLP P60 protein
M1S56_00580	COG1388	LysM domain
M1S56_00595	COG3150	esterase
M1S56_00605	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
M1S56_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S56_00630	COG2233	PERMEase
M1S56_00635	COG2351	hydroxyisourate hydrolase activity
M1S56_00670	COG3706	GGDEF domain
M1S56_00685	COG1393	Belongs to the ArsC family
M1S56_00690	COG0708	Exodeoxyribonuclease III
M1S56_00710	COG0189	ligase activity
M1S56_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M1S56_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M1S56_00755	COG4942	peptidase
M1S56_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S56_00775	COG2119	membrane
M1S56_00780	COG4774	siderophore transport
M1S56_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S56_00785	COG0426	domain, Protein
M1S56_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M1S56_00830	COG1902	pentaerythritol trinitrate reductase activity
M1S56_00835	COG1519	Transferase
M1S56_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S56_00845	COG0668	transmembrane transport
M1S56_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S56_00860	COG1335	isochorismatase
M1S56_00865	COG1522	sequence-specific DNA binding
M1S56_00870	COG3328	transposase activity
M1S56_00895	COG2198	Histidine kinase
M1S56_00895	COG2205	protein histidine kinase activity
M1S56_00895	COG0784	Response regulator, receiver
M1S56_00900	COG3162	membrane
M1S56_00905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S56_00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S56_00935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M1S56_00940	COG1309	transcriptional regulator
M1S56_00960	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S56_00960	COG0352	thiamine-phosphate diphosphorylase activity
M1S56_00960	COG0351	phosphomethylpyrimidine kinase
M1S56_00970	COG2814	Major facilitator Superfamily
M1S56_00985	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S56_00995	COG1113	amino acid transport
M1S56_01005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S56_01010	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_01020	COG1335	isochorismatase
M1S56_01050	COG2814	Major facilitator Superfamily
M1S56_01055	COG0583	DNA-binding transcription factor activity
M1S56_01075	COG0667	Aldo Keto reductase
M1S56_01110	COG1733	regulation of RNA biosynthetic process
M1S56_01115	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S56_01180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M1S56_01195	COG2329	Antibiotic biosynthesis monooxygenase
M1S56_01225	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M1S56_01255	COG0427	acetyl-CoA hydrolase
M1S56_01280	COG0659	secondary active sulfate transmembrane transporter activity
M1S56_01285	COG4221	oxidoreductase activity
M1S56_01290	COG2873	o-acetylhomoserine
M1S56_01295	COG0488	(ABC) transporter
M1S56_01380	COG0833	amino acid
M1S56_01425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M1S56_01430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M1S56_01445	COG2226	methyltransferase
M1S56_01495	COG0070	glutamate synthase
M1S56_01495	COG0069	glutamate synthase activity
M1S56_01495	COG0067	glutamate synthase
M1S56_01500	COG0493	'glutamate synthase
M1S56_01510	COG1704	LemA family
M1S56_01515	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M1S56_01535	COG3307	-O-antigen
M1S56_01560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S56_01575	COG0194	GDP metabolic process
M1S56_01625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M1S56_01645	COG5380	lipid catabolic process
M1S56_01650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M1S56_01675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M1S56_01680	COG0277	FAD linked oxidase domain protein
M1S56_01690	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M1S56_01695	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S56_01710	COG1289	transmembrane transporter activity
M1S56_01720	COG0628	permease
M1S56_01725	COG1192	Involved in chromosome partitioning
M1S56_01755	COG0833	amino acid
M1S56_01760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S56_01765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S56_01775	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_01815	COG0583	DNA-binding transcription factor activity
M1S56_01860	COG0517	IMP dehydrogenase activity
M1S56_01865	COG1983	PspC domain protein
M1S56_01875	COG1960	acyl-CoA dehydrogenase activity
M1S56_01890	COG0408	coproporphyrinogen oxidase activity
M1S56_01910	COG0513	Belongs to the DEAD box helicase family
M1S56_01920	COG1127	ABC transporter
M1S56_01925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M1S56_01935	COG2854	intermembrane phospholipid transfer
M1S56_01945	COG0598	Magnesium transport protein CorA
M1S56_01955	COG0494	nUDIX hydrolase
M1S56_01960	COG1040	competence protein
M1S56_01965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M1S56_01985	COG1946	Acyl-CoA thioesterase
M1S56_01990	COG1301	dicarboxylic acid transport
M1S56_02005	COG1959	2 iron, 2 sulfur cluster binding
M1S56_02010	COG1017	nitric oxide dioxygenase activity
M1S56_02010	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S56_02015	COG0433	COG0433 Predicted ATPase
M1S56_02020	COG0626	cystathionine gamma-synthase activity
M1S56_02175	COG1960	acyl-CoA dehydrogenase activity
M1S56_02180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
M1S56_02210	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
M1S56_02215	COG0339	signal peptide processing
M1S56_02220	COG0557	exoribonuclease II activity
M1S56_02265	COG0179	Fumarylacetoacetate (FAA) hydrolase
M1S56_02270	COG2169	Transcriptional regulator
M1S56_02275	COG0697	spore germination
M1S56_02280	COG1295	ribonuclease BN
M1S56_02315	COG1702	phosphate starvation-inducible protein PhoH
M1S56_02325	COG1196	nuclear chromosome segregation
M1S56_02325	COG0741	lytic transglycosylase activity
M1S56_02325	COG0739	heme binding
M1S56_02355	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M1S56_02360	COG1183	phosphatidylcholine synthase activity
M1S56_02410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M1S56_02415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M1S56_02420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M1S56_02430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M1S56_02480	COG1214	PFAM Peptidase M22, glycoprotease
M1S56_02505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M1S56_02510	COG0561	phosphatase activity
M1S56_02520	COG2132	Multicopper oxidase
M1S56_02525	COG3667	copper resistance
M1S56_02540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S56_02545	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M1S56_02550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M1S56_02580	COG1063	alcohol dehydrogenase
M1S56_02585	COG0583	DNA-binding transcription factor activity
M1S56_02590	COG1960	acyl-CoA dehydrogenase activity
M1S56_02595	COG2814	Major facilitator Superfamily
M1S56_02600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M1S56_02610	COG1053	succinate dehydrogenase
M1S56_02615	COG0583	DNA-binding transcription factor activity
M1S56_02630	COG0583	DNA-binding transcription factor activity
M1S56_02660	COG0583	DNA-binding transcription factor activity
M1S56_02675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S56_02700	COG0384	phenazine biosynthesis protein PhzF
M1S56_02735	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M1S56_02755	COG0745	RESPONSE REGULATOR receiver
M1S56_02795	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M1S56_02825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S56_02830	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M1S56_02850	COG0583	DNA-binding transcription factor activity
M1S56_02870	COG0668	transmembrane transport
M1S56_02880	COG2081	HI0933 family
M1S56_02885	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M1S56_02915	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S56_02915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S56_02925	COG0489	protein tyrosine kinase activity
M1S56_02975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S56_02985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M1S56_03000	COG0730	response to heat
M1S56_03010	COG1196	nuclear chromosome segregation
M1S56_03030	COG2223	nitrite transmembrane transporter activity
M1S56_03035	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M1S56_03040	COG1877	trehalose-phosphatase activity
M1S56_03045	COG2226	methyltransferase
M1S56_03045	COG0596	Alpha beta hydrolase
M1S56_03045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S56_03060	COG4106	trans-aconitate 2-methyltransferase activity
M1S56_03075	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M1S56_03080	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M1S56_03085	COG0009	L-threonylcarbamoyladenylate synthase
M1S56_03090	COG3101	peptidyl-lysine hydroxylation
M1S56_03095	COG1399	metal-binding, possibly nucleic acid-binding protein
M1S56_03120	COG1652	LysM domain
M1S56_03125	COG0351	phosphomethylpyrimidine kinase
M1S56_03125	COG0352	thiamine-phosphate diphosphorylase activity
M1S56_03125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M1S56_03135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M1S56_03165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S56_03195	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
M1S56_03210	COG0358	DNA primase activity
M1S56_03220	COG0564	pseudouridine synthase activity
M1S56_03245	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S56_03265	COG0583	DNA-binding transcription factor activity
M1S56_03270	COG0473	3-isopropylmalate dehydrogenase activity
M1S56_03280	COG0657	acetylesterase activity
M1S56_03290	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_03310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M1S56_03310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S56_03325	COG1981	membrane
M1S56_03370	COG0456	acetyltransferase
M1S56_03380	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M1S56_03385	COG0492	ferredoxin-NADP+ reductase activity
M1S56_03390	COG1674	ftsk spoiiie
M1S56_03390	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M1S56_03395	COG1280	lysine exporter protein (LysE YggA)
M1S56_03420	COG2894	cell division
M1S56_03435	COG0204	Acyl-transferase
M1S56_03440	COG2885	chlorophyll binding
M1S56_03445	COG0210	DNA helicase
M1S56_03455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S56_03470	COG0121	glutamine amidotransferase
M1S56_03490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M1S56_03495	COG0735	belongs to the Fur family
M1S56_03520	COG0420	3'-5' exonuclease activity
M1S56_03540	COG1090	epimerase
M1S56_03555	COG2050	protein possibly involved in aromatic compounds catabolism
M1S56_03565	COG2814	Major facilitator Superfamily
M1S56_03570	COG0405	Gamma-glutamyltransferase
M1S56_03605	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S56_03690	COG1484	DNA-dependent DNA replication
M1S56_03735	COG3755	Protein conserved in bacteria
M1S56_03880	COG2026	Addiction module toxin, RelE StbE family
M1S56_03920	COG0592	DNA-directed DNA polymerase activity
M1S56_04020	COG1061	Type III restriction enzyme res subunit
M1S56_04030	COG1192	Involved in chromosome partitioning
M1S56_04035	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S56_04045	COG1061	Type III restriction enzyme res subunit
M1S56_04065	COG1061	Type III restriction enzyme res subunit
M1S56_04075	COG1192	Involved in chromosome partitioning
M1S56_04080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S56_04090	COG1061	Type III restriction enzyme res subunit
M1S56_04110	COG1061	Type III restriction enzyme res subunit
M1S56_04120	COG1192	Involved in chromosome partitioning
M1S56_04125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S56_04150	COG0582	viral genome integration into host DNA
M1S56_04205	COG0629	single-stranded DNA binding
M1S56_04240	COG0084	hydrolase, TatD family'
M1S56_04260	COG0477	Major facilitator Superfamily
M1S56_04265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S56_04275	COG1595	DNA-templated transcription, initiation
M1S56_04330	COG0531	amino acid
M1S56_04335	COG2040	homocysteine
M1S56_04360	COG1309	transcriptional regulator
M1S56_04365	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S56_04370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S56_04380	COG1607	acyl-coa hydrolase
M1S56_04390	COG0523	cobalamin synthesis protein
M1S56_04400	COG4681	YaeQ
M1S56_04410	COG0726	polysaccharide deacetylase
M1S56_04410	COG1649	PFAM Uncharacterised BCR, COG1649
M1S56_04415	COG1215	transferase activity, transferring glycosyl groups
M1S56_04425	COG1024	Enoyl-CoA hydratase
M1S56_04440	COG1414	Transcriptional regulator
M1S56_04460	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_04470	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S56_04475	COG2271	Major facilitator Superfamily
M1S56_04485	COG2267	carboxylic ester hydrolase activity
M1S56_04490	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_04505	COG0028	Belongs to the TPP enzyme family
M1S56_04515	COG0477	Major facilitator Superfamily
M1S56_04520	COG0242	peptide deformylase activity
M1S56_04525	COG2066	Belongs to the glutaminase family
M1S56_04530	COG2207	Transcriptional regulator
M1S56_04535	COG2223	nitrite transmembrane transporter activity
M1S56_04550	COG0583	DNA-binding transcription factor activity
M1S56_04555	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_04560	COG2271	Major facilitator Superfamily
M1S56_04565	COG3959	Transketolase, thiamine diphosphate binding domain
M1S56_04570	COG3958	Transketolase
M1S56_04580	COG0306	phosphate transporter
M1S56_04600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M1S56_04645	COG4181	ATPase activity
M1S56_04650	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
M1S56_04675	COG0583	DNA-binding transcription factor activity
M1S56_04685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S56_04690	COG1773	rubredoxin
M1S56_04740	COG2851	Citrate transporter
M1S56_04745	COG1253	flavin adenine dinucleotide binding
M1S56_04785	COG0804	urea catabolic process
M1S56_04795	COG0830	nickel cation binding
M1S56_04810	COG0742	ribosomal rna small subunit methyltransferase
M1S56_04815	COG0768	penicillin binding
M1S56_04840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M1S56_04845	COG2878	Part of a membrane complex involved in electron transport
M1S56_04850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M1S56_04860	COG3384	dioxygenase
M1S56_04885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M1S56_05210	COG0739	heme binding
M1S56_05255	COG2194	sulfuric ester hydrolase activity
M1S56_05315	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S56_05330	COG0305	Participates in initiation and elongation during chromosome replication
M1S56_05490	COG0739	heme binding
M1S56_05490	COG0741	lytic transglycosylase activity
M1S56_05490	COG1196	nuclear chromosome segregation
M1S56_05610	COG0305	Participates in initiation and elongation during chromosome replication
M1S56_05710	COG4695	Portal protein
M1S56_05770	COG1196	nuclear chromosome segregation
M1S56_05770	COG0741	lytic transglycosylase activity
M1S56_05770	COG0739	heme binding
M1S56_05855	COG0006	proline dipeptidase activity
M1S56_05860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S56_05865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S56_05885	COG1279	arginine transmembrane transporter activity
M1S56_05890	COG0583	DNA-binding transcription factor activity
M1S56_05930	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S56_05935	COG1388	LysM domain
M1S56_05935	COG0741	lytic transglycosylase activity
M1S56_05935	COG0741	lytic transglycosylase activity
M1S56_05935	COG1388	LysM domain
M1S56_05945	COG4174	ABC transporter (Permease)
M1S56_05950	COG4239	(ABC) transporter, permease
M1S56_05955	COG4172	Belongs to the ABC transporter superfamily
M1S56_05975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S56_05985	COG2203	Gaf domain
M1S56_05985	COG4251	negative regulation of phosphorylation
M1S56_05985	COG3706	GGDEF domain
M1S56_05985	COG5001	Diguanylate cyclase
M1S56_05995	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S56_05995	COG1902	pentaerythritol trinitrate reductase activity
M1S56_06010	COG4269	membrane
M1S56_06070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S56_06075	COG2011	ABC-type metal ion transport system permease component
M1S56_06080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S56_06085	COG1464	Belongs to the NlpA lipoprotein family
M1S56_06090	COG0151	Belongs to the GarS family
M1S56_06095	COG0138	bifunctional purine biosynthesis protein purh
M1S56_06100	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
M1S56_06130	COG2308	Evidence 4 Homologs of previously reported genes of
M1S56_06140	COG1305	Transglutaminase-like
M1S56_06150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M1S56_06155	COG0305	Participates in initiation and elongation during chromosome replication
M1S56_06180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M1S56_06190	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M1S56_06195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M1S56_06220	COG1649	PFAM Uncharacterised BCR, COG1649
M1S56_06220	COG0726	polysaccharide deacetylase
M1S56_06225	COG1215	transferase activity, transferring glycosyl groups
M1S56_06230	COG3658	cytochrome
M1S56_06240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S56_06255	COG0583	DNA-binding transcription factor activity
M1S56_06275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S56_06280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S56_06295	COG1960	acyl-CoA dehydrogenase activity
M1S56_06300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S56_06305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S56_06330	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
M1S56_06335	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M1S56_06345	COG2205	protein histidine kinase activity
M1S56_06350	COG0745	RESPONSE REGULATOR receiver
M1S56_06355	COG0174	glutamine synthetase
M1S56_06375	COG0729	surface antigen
M1S56_06400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S56_06405	COG2814	Major facilitator Superfamily
M1S56_06420	COG0583	DNA-binding transcription factor activity
M1S56_06435	COG1187	pseudouridine synthase activity
M1S56_06455	COG0802	atpase or kinase
M1S56_06460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M1S56_06470	COG1923	regulation of RNA biosynthetic process
M1S56_06475	COG0697	spore germination
M1S56_06490	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S56_06500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S56_06505	COG0519	Catalyzes the synthesis of GMP from XMP
M1S56_06505	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S56_06510	COG4302	ethanolamine ammonia-lyase activity
M1S56_06515	COG4303	Ethanolamine ammonia lyase large subunit
M1S56_06520	COG0531	amino acid
M1S56_06540	COG1454	alcohol dehydrogenase
M1S56_06545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S56_06555	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
M1S56_06575	COG0308	aminopeptidase N
M1S56_06585	COG4221	oxidoreductase activity
M1S56_06595	COG1605	Chorismate mutase
M1S56_06615	COG1309	transcriptional regulator
M1S56_06625	COG0668	transmembrane transport
M1S56_06660	COG4773	Receptor
M1S56_06680	COG0488	(ABC) transporter
M1S56_06685	COG0589	response to stress
M1S56_06710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M1S56_06720	COG3135	benzoate transporter
M1S56_06725	COG1522	sequence-specific DNA binding
M1S56_06735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M1S56_06740	COG0583	DNA-binding transcription factor activity
M1S56_06750	COG0183	Belongs to the thiolase family
M1S56_06760	COG2030	dehydratase
M1S56_06765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S56_06780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M1S56_06790	COG0824	Thioesterase
M1S56_06795	COG1454	alcohol dehydrogenase
M1S56_06805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M1S56_06825	COG0069	glutamate synthase activity
M1S56_06895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S56_06900	COG4197	protein conserved in bacteria, prophage-related
M1S56_06985	COG5410	chromosome segregation
M1S56_07130	COG0739	heme binding
M1S56_07130	COG0741	lytic transglycosylase activity
M1S56_07130	COG1196	nuclear chromosome segregation
M1S56_07200	COG2814	Major facilitator Superfamily
M1S56_07215	COG0511	ligase activity, forming carbon-carbon bonds
M1S56_07235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S56_07235	COG1116	anion transmembrane transporter activity
M1S56_07240	COG0745	RESPONSE REGULATOR receiver
M1S56_07250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S56_07250	COG2146	nitrite reductase [NAD(P)H] activity
M1S56_07255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S56_07260	COG0243	molybdopterin cofactor binding
M1S56_07270	COG0243	molybdopterin cofactor binding
M1S56_07275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M1S56_07290	COG0315	cyclic pyranopterin monophosphate synthase activity
M1S56_07290	COG0521	Mo-molybdopterin cofactor biosynthetic process
M1S56_07295	COG0303	'Molybdopterin
M1S56_07305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S56_07310	COG0697	spore germination
M1S56_07330	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
M1S56_07335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S56_07400	COG2204	response regulator
M1S56_07405	COG3852	Histidine kinase
M1S56_07425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M1S56_07430	COG0575	Belongs to the CDS family
M1S56_07465	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S56_07480	COG2137	regulation of response to DNA damage stimulus
M1S56_07490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M1S56_07495	COG1011	Hydrolase
M1S56_07520	COG1522	sequence-specific DNA binding
M1S56_07530	COG1113	amino acid transport
M1S56_07550	COG0659	secondary active sulfate transmembrane transporter activity
M1S56_07555	COG2135	peptidase activity
M1S56_07570	COG5001	Diguanylate cyclase
M1S56_07570	COG3300	MHYT domain
M1S56_07590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
M1S56_07590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S56_07590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M1S56_07595	COG1105	Belongs to the carbohydrate kinase PfkB family
M1S56_07600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S56_07600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M1S56_07630	COG0024	Methionine aminopeptidase
M1S56_07635	COG0583	DNA-binding transcription factor activity
M1S56_07645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M1S56_07650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M1S56_07655	COG0517	IMP dehydrogenase activity
M1S56_07655	COG0516	GMP reductase activity
M1S56_07680	COG0552	protein localization to endoplasmic reticulum
M1S56_07690	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
M1S56_07705	COG4890	Cyd operon protein YbgT
M1S56_07710	COG1294	oxidase, subunit
M1S56_07730	COG1585	Membrane protein implicated in regulation of membrane protease activity
M1S56_07740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M1S56_07745	COG4774	siderophore transport
M1S56_07760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M1S56_07765	COG0569	domain protein
M1S56_07770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S56_07800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M1S56_07805	COG0542	response to heat
M1S56_07830	COG1902	pentaerythritol trinitrate reductase activity
M1S56_07830	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S56_07875	COG2323	membrane
M1S56_07880	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M1S56_07890	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S56_07895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S56_07900	COG0183	Belongs to the thiolase family
M1S56_07905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M1S56_07910	COG0596	Alpha beta hydrolase
M1S56_07915	COG2271	Major facilitator Superfamily
M1S56_07920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S56_07925	COG3485	protocatechuate 3,4-dioxygenase
M1S56_07930	COG3485	protocatechuate 3,4-dioxygenase
M1S56_07935	COG0710	3-dehydroquinate dehydratase activity
M1S56_07940	COG3420	alginic acid biosynthetic process
M1S56_07945	COG3659	wide pore channel activity
M1S56_07950	COG4993	Dehydrogenase
M1S56_07960	COG2391	methyltransferase activity
M1S56_07975	COG1414	Transcriptional regulator
M1S56_07980	COG0583	DNA-binding transcription factor activity
M1S56_07985	COG1960	acyl-CoA dehydrogenase activity
M1S56_08010	COG2814	Major facilitator Superfamily
M1S56_08020	COG0154	amidase activity
M1S56_08040	COG4638	Rieske (2fe-2S)
M1S56_08050	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_08060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S56_08070	COG3733	amine oxidase
M1S56_08080	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_08090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S56_08095	COG0183	Belongs to the thiolase family
M1S56_08100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S56_08105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S56_08115	COG4829	muconolactone delta-isomerase
M1S56_08120	COG4948	Mandelate Racemase Muconate Lactonizing
M1S56_08125	COG0583	DNA-binding transcription factor activity
M1S56_08135	COG2186	Transcriptional regulator
M1S56_08155	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_08175	COG1960	acyl-CoA dehydrogenase activity
M1S56_08180	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_08185	COG3829	transcription factor binding
M1S56_08195	COG3162	membrane
M1S56_08210	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_08225	COG0753	catalase activity
M1S56_08245	COG1846	Transcriptional regulator
M1S56_08250	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S56_08250	COG1902	pentaerythritol trinitrate reductase activity
M1S56_08260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M1S56_08290	COG1309	transcriptional regulator
M1S56_08300	COG1335	isochorismatase
M1S56_08305	COG0583	DNA-binding transcription factor activity
M1S56_08315	COG0475	glutathione-regulated potassium exporter activity
M1S56_08315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S56_08325	COG1473	amidohydrolase
M1S56_08335	COG2831	hemolysin activation secretion protein
M1S56_08340	COG3210	domain, Protein
M1S56_08370	COG2188	Transcriptional regulator
M1S56_08385	COG0583	DNA-binding transcription factor activity
M1S56_08415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S56_08445	COG1566	PFAM secretion protein HlyD family protein
M1S56_08460	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_08465	COG0129	dihydroxy-acid dehydratase activity
M1S56_08475	COG0583	DNA-binding transcription factor activity
M1S56_08480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M1S56_08490	COG2084	Dehydrogenase
M1S56_08495	COG2207	Transcriptional regulator
M1S56_08510	COG1064	alcohol dehydrogenase
M1S56_08520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S56_08525	COG1120	ATPase activity
M1S56_08545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M1S56_08665	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M1S56_08715	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_08730	COG2207	Transcriptional regulator
M1S56_08745	COG2205	protein histidine kinase activity
M1S56_08750	COG0745	RESPONSE REGULATOR receiver
M1S56_08755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S56_08760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S56_08765	COG1538	Outer membrane efflux protein
M1S56_08775	COG2072	flavoprotein involved in K transport
M1S56_08795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S56_08900	COG3539	Fimbrial protein
M1S56_08930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
M1S56_08940	COG0753	catalase activity
M1S56_08955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S56_09015	COG1535	isochorismatase
M1S56_09015	COG3433	isochorismatase activity
M1S56_09020	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_09090	COG3409	Peptidoglycan-binding domain 1 protein
M1S56_09090	COG3267	Type II secretory pathway component ExeA
M1S56_09120	COG0681	Belongs to the peptidase S26 family
M1S56_09155	COG4373	Mu-like prophage FluMu protein gp28
M1S56_09170	COG4383	Mu-like prophage protein gp29
M1S56_09175	COG2369	cell adhesion
M1S56_09180	COG5005	Phage virion morphogenesis
M1S56_09195	COG4397	Mu-like prophage major head subunit gpT
M1S56_09285	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M1S56_09290	COG4149	molybdate abc transporter
M1S56_09295	COG0725	ABC transporter, periplasmic molybdate-binding protein
M1S56_09305	COG4638	Rieske (2fe-2S)
M1S56_09310	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S56_09315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S56_09315	COG0543	2 iron, 2 sulfur cluster binding
M1S56_09340	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_09355	COG2207	Transcriptional regulator
M1S56_09365	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_09370	COG2610	gluconate transmembrane transporter activity
M1S56_09380	COG0583	DNA-binding transcription factor activity
M1S56_09390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S56_09395	COG2031	fatty acid transporter
M1S56_09400	COG0183	Belongs to the thiolase family
M1S56_09405	COG0583	DNA-binding transcription factor activity
M1S56_09410	COG0583	DNA-binding transcription factor activity
M1S56_09425	COG1027	Aspartate ammonia-lyase
M1S56_09435	COG0477	Major facilitator Superfamily
M1S56_09455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S56_09460	COG4521	taurine ABC transporter
M1S56_09475	COG2188	Transcriptional regulator
M1S56_09485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M1S56_09490	COG1733	regulation of RNA biosynthetic process
M1S56_09495	COG3708	Transcriptional regulator
M1S56_09495	COG2207	Transcriptional regulator
M1S56_09510	COG0730	response to heat
M1S56_09525	COG3453	Protein conserved in bacteria
M1S56_09525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S56_09535	COG3781	membrane
M1S56_09540	COG1063	alcohol dehydrogenase
M1S56_09550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S56_09555	COG0508	dehydrogenase complex catalyzes the overall conversion of
M1S56_09560	COG0022	dehydrogenase e1 component
M1S56_09565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M1S56_09570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S56_09585	COG3706	GGDEF domain
M1S56_09600	COG0133	tryptophan synthase activity
M1S56_09610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S56_09645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M1S56_09670	COG2226	methyltransferase
M1S56_09725	COG0842	Transport permease protein
M1S56_09730	COG0842	Transport permease protein
M1S56_09735	COG1131	(ABC) transporter
M1S56_09750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M1S56_09755	COG4773	Receptor
M1S56_09775	COG0730	response to heat
M1S56_09780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M1S56_09800	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M1S56_09815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S56_09855	COG4264	IucA IucC family
M1S56_09860	COG4264	IucA IucC family
M1S56_09880	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M1S56_09895	COG1960	acyl-CoA dehydrogenase activity
M1S56_09900	COG1960	acyl-CoA dehydrogenase activity
M1S56_09905	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M1S56_09910	COG2207	Transcriptional regulator
M1S56_09915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S56_09920	COG0776	regulation of translation
M1S56_09945	COG0822	iron-sulfur transferase activity
M1S56_09950	COG0316	Belongs to the HesB IscA family
M1S56_09980	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M1S56_10010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M1S56_10015	COG0702	epimerase
M1S56_10050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M1S56_10060	COG0339	signal peptide processing
M1S56_10110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M1S56_10115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M1S56_10145	COG0776	regulation of translation
M1S56_10210	COG0084	hydrolase, TatD family'
M1S56_10230	COG1663	tetraacyldisaccharide 4'-kinase activity
M1S56_10235	COG1132	(ABC) transporter
M1S56_10245	COG0811	peptide transport
M1S56_10250	COG1475	DNA binding
M1S56_10255	COG1192	Involved in chromosome partitioning
M1S56_10265	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S56_10280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M1S56_10285	COG0191	fructose-bisphosphate aldolase activity
M1S56_10305	COG0424	maF-like protein
M1S56_10310	COG2850	peptidyl-arginine hydroxylation
M1S56_10320	COG0640	Transcriptional regulator
M1S56_10330	COG3619	membrane
M1S56_10335	COG3122	Protein conserved in bacteria
M1S56_10340	COG1132	(ABC) transporter
M1S56_10360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M1S56_10365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M1S56_10375	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S56_10375	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M1S56_10375	COG0506	proline dehydrogenase activity
M1S56_10380	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M1S56_10395	COG3698	Phosphodiester glycosidase
M1S56_10405	COG2353	YceI-like domain
M1S56_10415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M1S56_10460	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M1S56_10460	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M1S56_10485	COG3539	Fimbrial protein
M1S56_10490	COG3121	Chaperone
M1S56_10515	COG0697	spore germination
M1S56_10525	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S56_10535	COG0583	DNA-binding transcription factor activity
M1S56_10555	COG1309	transcriptional regulator
M1S56_10570	COG1522	sequence-specific DNA binding
M1S56_10585	COG1126	abc transporter atp-binding protein
M1S56_10590	COG0765	amino acid transport
M1S56_10595	COG0765	amino acid transport
M1S56_10625	COG1464	Belongs to the NlpA lipoprotein family
M1S56_10635	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M1S56_10640	COG2011	ABC-type metal ion transport system permease component
M1S56_10645	COG0012	GTP binding
M1S56_10670	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M1S56_10710	COG0386	Belongs to the glutathione peroxidase family
M1S56_10720	COG0436	Aminotransferase
M1S56_10760	COG3634	alkyl hydroperoxide reductase activity
M1S56_10775	COG0583	DNA-binding transcription factor activity
M1S56_10780	COG0798	PFAM Bile acid sodium symporter
M1S56_10785	COG0640	Transcriptional regulator
M1S56_10800	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M1S56_10810	COG0583	DNA-binding transcription factor activity
M1S56_10820	COG1953	Uracil, thiamine, allantoin
M1S56_10830	COG2175	clavaminate synthase activity
M1S56_10835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S56_10840	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M1S56_10845	COG4521	taurine ABC transporter
M1S56_10855	COG0477	Major facilitator Superfamily
M1S56_10875	COG1271	oxidase subunit
M1S56_10880	COG1294	oxidase, subunit
M1S56_10890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S56_10910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M1S56_10930	COG3052	prosthetic group binding
M1S56_10935	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
M1S56_10945	COG2814	Major facilitator Superfamily
M1S56_10965	COG1346	cytolysis
M1S56_10975	COG0583	DNA-binding transcription factor activity
M1S56_10980	COG0625	glutathione transferase activity
M1S56_10985	COG0625	glutathione transferase activity
M1S56_10990	COG0583	DNA-binding transcription factor activity
M1S56_11005	COG1045	serine acetyltransferase
M1S56_11010	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M1S56_11015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M1S56_11025	COG1280	lysine exporter protein (LysE YggA)
M1S56_11040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S56_11045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S56_11050	COG1126	abc transporter atp-binding protein
M1S56_11055	COG0765	amino acid transport
M1S56_11060	COG0765	amino acid transport
M1S56_11080	COG0784	Response regulator, receiver
M1S56_11080	COG2205	protein histidine kinase activity
M1S56_11100	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M1S56_11120	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_11170	COG0583	DNA-binding transcription factor activity
M1S56_11195	COG0318	PFAM AMP-dependent synthetase and ligase
M1S56_11200	COG1309	transcriptional regulator
M1S56_11205	COG1960	acyl-CoA dehydrogenase activity
M1S56_11210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S56_11215	COG1024	Enoyl-CoA hydratase
M1S56_11220	COG4770	biotin carboxylase activity
M1S56_11230	COG0583	DNA-binding transcription factor activity
M1S56_11245	COG1960	acyl-CoA dehydrogenase activity
M1S56_11255	COG2814	Major facilitator Superfamily
M1S56_11265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M1S56_11270	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M1S56_11275	COG2814	Major facilitator Superfamily
M1S56_11280	COG1960	acyl-CoA dehydrogenase activity
M1S56_11285	COG1024	Enoyl-CoA hydratase
M1S56_11290	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_11295	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S56_11300	COG0183	Belongs to the thiolase family
M1S56_11310	COG2814	Major facilitator Superfamily
M1S56_11320	COG1024	Enoyl-CoA hydratase
M1S56_11335	COG1960	acyl-CoA dehydrogenase activity
M1S56_11340	COG2814	Major facilitator Superfamily
M1S56_11345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M1S56_11350	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M1S56_11375	COG3842	ATPase activity
M1S56_11380	COG1840	ABC-type Fe3 transport system, periplasmic component
M1S56_11390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S56_11395	COG1414	Transcriptional regulator
M1S56_11405	COG0583	DNA-binding transcription factor activity
M1S56_11410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M1S56_11415	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_11425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
M1S56_11435	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_11440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S56_11445	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M1S56_11450	COG2267	carboxylic ester hydrolase activity
M1S56_11470	COG3038	cytochrome b561
M1S56_11475	COG0753	catalase activity
M1S56_11510	COG2050	protein possibly involved in aromatic compounds catabolism
M1S56_11520	COG3327	negative regulation of DNA-templated transcription, initiation
M1S56_11525	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
M1S56_11530	COG0183	Belongs to the thiolase family
M1S56_11535	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S56_11540	COG1024	Enoyl-CoA hydratase
M1S56_11545	COG1024	Enoyl-CoA hydratase
M1S56_11550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S56_11555	COG2151	metal-sulfur cluster biosynthetic enzyme
M1S56_11560	COG3396	Phenylacetate-CoA oxygenase
M1S56_11565	COG3460	Phenylacetate-CoA oxygenase
M1S56_11570	COG3396	Phenylacetate-CoA oxygenase
M1S56_11575	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_11575	COG2030	dehydratase
M1S56_11580	COG1760	l-serine dehydratase
M1S56_11585	COG0531	amino acid
M1S56_11590	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_11605	COG0446	pyridine nucleotide-disulphide oxidoreductase
M1S56_11615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S56_11635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S56_11645	COG0789	Transcriptional regulator
M1S56_11660	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M1S56_11675	COG2807	transmembrane transport
M1S56_11680	COG0590	tRNA wobble adenosine to inosine editing
M1S56_11800	COG1116	anion transmembrane transporter activity
M1S56_11805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M1S56_11815	COG0864	Transcriptional regulator
M1S56_11835	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S56_11840	COG0439	Biotin carboxylase
M1S56_11855	COG1063	alcohol dehydrogenase
M1S56_11865	COG1309	transcriptional regulator
M1S56_11885	COG0038	chloride channel
M1S56_11890	COG4770	biotin carboxylase activity
M1S56_11910	COG1914	H( )-stimulated, divalent metal cation uptake system
M1S56_11915	COG0583	DNA-binding transcription factor activity
M1S56_11965	COG1250	3-hydroxyacyl-CoA dehydrogenase
M1S56_11985	COG2814	Major facilitator Superfamily
M1S56_12000	COG1560	Kdo2-lipid A biosynthetic process
M1S56_12010	COG5006	permease, DMT superfamily
M1S56_12015	COG1522	sequence-specific DNA binding
M1S56_12030	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M1S56_12040	COG4122	O-methyltransferase activity
M1S56_12070	COG1538	Outer membrane efflux protein
M1S56_12075	COG1137	ATPase activity
M1S56_12080	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M1S56_12090	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
M1S56_12095	COG0517	IMP dehydrogenase activity
M1S56_12095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M1S56_12130	COG2814	Major facilitator Superfamily
M1S56_12165	COG1278	Cold shock
M1S56_12170	COG1280	lysine exporter protein (LysE YggA)
M1S56_12200	COG1570	exodeoxyribonuclease VII activity
M1S56_12250	COG0583	DNA-binding transcription factor activity
M1S56_12260	COG4638	Rieske (2fe-2S)
M1S56_12265	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
M1S56_12270	COG0543	2 iron, 2 sulfur cluster binding
M1S56_12270	COG0633	Ferredoxin
M1S56_12275	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_12280	COG3135	benzoate transporter
M1S56_12285	COG2814	Major facilitator Superfamily
M1S56_12300	COG1643	Atp-dependent helicase
M1S56_12305	COG0450	alkyl hydroperoxide reductase
M1S56_12315	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M1S56_12325	COG3634	alkyl hydroperoxide reductase activity
M1S56_12350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M1S56_12355	COG0625	glutathione transferase activity
M1S56_12365	COG2885	chlorophyll binding
M1S56_12400	COG0542	response to heat
M1S56_12415	COG1765	OsmC-like protein
M1S56_12435	COG0667	Aldo Keto reductase
M1S56_12450	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M1S56_12460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M1S56_12470	COG0582	viral genome integration into host DNA
M1S56_12495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S56_12595	COG0592	DNA-directed DNA polymerase activity
M1S56_12840	COG1484	DNA-dependent DNA replication
M1S56_12920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M1S56_12960	COG0527	aspartate kinase activity
M1S56_12970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M1S56_12980	COG3038	cytochrome b561
M1S56_13085	COG1794	racemase activity, acting on amino acids and derivatives
M1S56_13095	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M1S56_13095	COG3008	intermembrane lipid transfer
M1S56_13100	COG2995	paraquat-inducible protein a
M1S56_13110	COG2985	domain, Protein
M1S56_13140	COG0477	Major facilitator Superfamily
M1S56_13190	COG2186	Transcriptional regulator
M1S56_13200	COG0786	glutamate:sodium symporter activity
M1S56_13205	COG3243	poly(R)-hydroxyalkanoic acid synthase
M1S56_13230	COG3111	PFAM Bacterial OB fold (BOF) protein
M1S56_13330	COG1610	YqeY-like protein
M1S56_13335	COG4783	chaperone-mediated protein folding
M1S56_13360	COG1286	toxin biosynthetic process
M1S56_13710	COG0778	Nitroreductase
M1S56_13720	COG0513	Belongs to the DEAD box helicase family
M1S56_13745	COG2363	Small membrane protein
M1S56_13775	COG1234	tRNA 3'-trailer cleavage
M1S56_13780	COG2195	Cleaves the N-terminal amino acid of tripeptides
M1S56_13790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M1S56_13800	COG2819	hydrolase of the alpha beta superfamily
M1S56_13805	COG1960	acyl-CoA dehydrogenase activity
M1S56_13810	COG1301	dicarboxylic acid transport
M1S56_13815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M1S56_13820	COG3139	Protein of unknown function (DUF1315)
M1S56_13825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M1S56_13830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M1S56_13840	COG0494	nUDIX hydrolase
M1S56_13850	COG0642	Histidine kinase
M1S56_13865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M1S56_13875	COG1720	tRNA m6t6A37 methyltransferase activity
M1S56_13890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S56_13895	COG0826	peptidase U32
M1S56_13900	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
M1S56_13910	COG4598	ABC transporter
M1S56_13915	COG4160	amino acid transport
M1S56_13920	COG4215	(ABC) transporter
M1S56_13935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S56_13980	COG1131	(ABC) transporter
M1S56_13985	COG0842	Transport permease protein
M1S56_14000	COG0772	Belongs to the SEDS family
M1S56_14005	COG2951	lytic endotransglycosylase activity
M1S56_14030	COG2207	Transcriptional regulator
M1S56_14045	COG0052	Belongs to the universal ribosomal protein uS2 family
M1S56_14050	COG0024	Methionine aminopeptidase
M1S56_14060	COG2223	nitrite transmembrane transporter activity
M1S56_14070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S56_14075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M1S56_14080	COG1960	acyl-CoA dehydrogenase activity
M1S56_14095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M1S56_14100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M1S56_14105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M1S56_14125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S56_14130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M1S56_14135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M1S56_14170	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M1S56_14180	COG0174	glutamine synthetase
M1S56_14195	COG0512	Glutamine amidotransferase of anthranilate synthase
M1S56_14200	COG0308	aminopeptidase N
M1S56_14230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M1S56_14240	COG0302	gtp cyclohydrolase
M1S56_14265	COG3739	integral membrane protein
M1S56_14280	COG1169	isochorismate synthase
M1S56_14290	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M1S56_14295	COG1132	(ABC) transporter
M1S56_14300	COG1132	(ABC) transporter
M1S56_14315	COG1535	isochorismatase
M1S56_14315	COG3433	isochorismatase activity
M1S56_14320	COG1021	2,3-dihydroxybenzoate-AMP ligase
M1S56_14325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S56_14335	COG4774	siderophore transport
M1S56_14340	COG4607	ABC-type enterochelin transport system periplasmic component
M1S56_14345	COG4604	ABC transporter, ATP-binding protein
M1S56_14350	COG4605	iron ion homeostasis
M1S56_14355	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M1S56_14360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S56_14375	COG2964	Protein conserved in bacteria
M1S56_14385	COG1741	Belongs to the pirin family
M1S56_14405	COG1309	transcriptional regulator
M1S56_14415	COG4948	Mandelate Racemase Muconate Lactonizing
M1S56_14420	COG2814	Major facilitator Superfamily
M1S56_14455	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M1S56_14455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M1S56_14460	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S56_14470	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_14480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S56_14485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M1S56_14490	COG0583	DNA-binding transcription factor activity
M1S56_14495	COG1113	amino acid transport
M1S56_14515	COG2508	Transcriptional regulator
M1S56_14515	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M1S56_14550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S56_14670	COG4695	Portal protein
M1S56_14675	COG4626	Terminase
M1S56_14675	COG1802	Transcriptional regulator
M1S56_14780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S56_14910	COG4695	Portal protein
M1S56_14915	COG1802	Transcriptional regulator
M1S56_14915	COG4626	Terminase
M1S56_15020	COG2879	small protein
M1S56_15025	COG1966	Carbon starvation protein
M1S56_15070	COG1067	ATP-dependent peptidase activity
M1S56_15075	COG0583	DNA-binding transcription factor activity
M1S56_15100	COG1686	Belongs to the peptidase S11 family
M1S56_15105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M1S56_15140	COG0616	signal peptide processing
M1S56_15145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M1S56_15155	COG0573	inorganic phosphate transmembrane transporter activity
M1S56_15160	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M1S56_15165	COG1113	amino acid transport
M1S56_15170	COG3961	Belongs to the TPP enzyme family
M1S56_15175	COG1522	sequence-specific DNA binding
M1S56_15185	COG0076	glutamate decarboxylase activity
M1S56_15190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M1S56_15200	COG1309	transcriptional regulator
M1S56_15215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M1S56_15250	COG0352	thiamine-phosphate diphosphorylase activity
M1S56_15275	COG0612	Peptidase, M16
M1S56_15285	COG1823	symporter activity
M1S56_15290	COG0583	DNA-binding transcription factor activity
M1S56_15295	COG0477	Major facilitator Superfamily
M1S56_15320	COG1187	pseudouridine synthase activity
M1S56_15335	COG1686	Belongs to the peptidase S11 family
M1S56_15340	COG1252	NADH dehydrogenase
M1S56_15350	COG0415	Belongs to the DNA photolyase family
M1S56_15365	COG1215	transferase activity, transferring glycosyl groups
M1S56_15395	COG2070	2-Nitropropane dioxygenase
M1S56_15450	COG0556	nucleotide-excision repair
M1S56_15470	COG0436	Aminotransferase
M1S56_15500	COG4221	oxidoreductase activity
M1S56_15510	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M1S56_15515	COG1381	Involved in DNA repair and RecF pathway recombination
M1S56_15525	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M1S56_15540	COG0681	Belongs to the peptidase S26 family
M1S56_15555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M1S56_15575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M1S56_15580	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M1S56_15585	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M1S56_15595	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M1S56_15600	COG4208	sulfate ABC transporter
M1S56_15605	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M1S56_15610	COG0583	DNA-binding transcription factor activity
M1S56_15615	COG4625	pathogenesis
M1S56_15630	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M1S56_15645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M1S56_15655	COG1051	belongs to the nudix hydrolase family
M1S56_15655	COG1056	cytidyltransferase-related domain
M1S56_15660	COG1024	Enoyl-CoA hydratase
M1S56_15670	COG2814	Major facilitator Superfamily
M1S56_15675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M1S56_15675	COG0047	phosphoribosylformylglycinamidine synthase activity
M1S56_15695	COG1473	amidohydrolase
M1S56_15700	COG0824	Thioesterase
M1S56_15720	COG0823	Involved in the tonB-independent uptake of proteins
M1S56_15740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S56_15775	COG0628	permease
M1S56_15785	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M1S56_15790	COG0596	Alpha beta hydrolase
M1S56_15795	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M1S56_15795	COG0616	signal peptide processing
M1S56_15805	COG2333	competence protein COMEC
M1S56_15805	COG0658	competence protein
M1S56_15810	COG1136	(ABC) transporter
M1S56_15815	COG4591	ABC-type transport system involved in lipoprotein release permease component
M1S56_15850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S56_15870	COG0463	Glycosyl transferase, family 2
M1S56_15900	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S56_15905	COG1280	lysine exporter protein (LysE YggA)
M1S56_15915	COG0019	diaminopimelate decarboxylase activity
M1S56_15925	COG1113	amino acid transport
M1S56_15940	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
M1S56_15950	COG3339	Conserved Protein
M1S56_15955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M1S56_15960	COG0243	molybdopterin cofactor binding
M1S56_15965	COG1929	Belongs to the glycerate kinase type-1 family
M1S56_15980	COG0778	Nitroreductase
M1S56_16010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S56_16025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M1S56_16045	COG0741	lytic transglycosylase activity
M1S56_16065	COG0584	glycerophosphoryl diester phosphodiesterase
M1S56_16095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S56_16100	COG1597	lipid kinase activity
M1S56_16115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M1S56_16120	COG0477	Major facilitator Superfamily
M1S56_16170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M1S56_16175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M1S56_16200	COG0505	Belongs to the CarA family
M1S56_16220	COG0589	response to stress
M1S56_16235	COG2843	Capsule synthesis protein
M1S56_16255	COG2321	neutral zinc metallopeptidase
M1S56_16260	COG2354	Protein conserved in bacteria
M1S56_16280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M1S56_16305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M1S56_16310	COG1053	succinate dehydrogenase
M1S56_16315	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M1S56_16320	COG2009	succinate dehydrogenase
M1S56_16360	COG2921	Belongs to the UPF0250 family
M1S56_16365	COG0321	lipoyl(octanoyl) transferase activity
M1S56_16380	COG0531	amino acid
M1S56_16390	COG1733	regulation of RNA biosynthetic process
M1S56_16395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M1S56_16400	COG1648	precorrin-2 dehydrogenase activity
M1S56_16400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M1S56_16415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M1S56_16445	COG0671	phosphoesterase, PA-phosphatase related
M1S56_16450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S56_16460	COG1538	Outer membrane efflux protein
M1S56_16465	COG0393	Putative heavy-metal-binding
M1S56_16470	COG0393	Putative heavy-metal-binding
M1S56_16480	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_16490	COG0525	valine-tRNA ligase activity
M1S56_16510	COG0583	DNA-binding transcription factor activity
M1S56_16515	COG0004	ammonium transporteR
M1S56_16525	COG0642	Histidine kinase
M1S56_16530	COG0745	RESPONSE REGULATOR receiver
M1S56_16535	COG2194	sulfuric ester hydrolase activity
M1S56_16555	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S56_16570	COG2315	Protein conserved in bacteria
M1S56_16575	COG0142	geranyltranstransferase activity
M1S56_16580	COG2828	Protein conserved in bacteria
M1S56_16585	COG1113	amino acid transport
M1S56_16605	COG2207	Transcriptional regulator
M1S56_16630	COG2249	NAD(P)H dehydrogenase (quinone) activity
M1S56_16640	COG0560	Phosphoserine phosphatase
M1S56_16650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M1S56_16660	COG1530	ribonuclease E activity
M1S56_16665	COG0424	maF-like protein
M1S56_16670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M1S56_16675	COG1792	Involved in formation and maintenance of cell shape
M1S56_16680	COG1077	Cell shape determining protein MreB Mrl
M1S56_16685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S56_16695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M1S56_16725	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M1S56_16730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M1S56_16735	COG1752	Esterase of the alpha-beta hydrolase superfamily
M1S56_16740	COG1115	amino acid carrier protein
M1S56_16760	COG2814	Major facilitator Superfamily
M1S56_16765	COG1289	transmembrane transporter activity
M1S56_16775	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M1S56_16815	COG1376	ErfK ybiS ycfS ynhG family protein
M1S56_16820	COG2832	Protein of unknown function (DUF454)
M1S56_16830	COG5510	response to toxic substance
M1S56_16850	COG0840	transmembrane signaling receptor activity
M1S56_16890	COG3422	double-strand break repair
M1S56_16895	COG2824	Alkylphosphonate utilization operon protein PhnA
M1S56_16900	COG3189	MarR family transcriptional regulator
M1S56_16910	COG0354	folic acid binding
M1S56_16915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S56_16925	COG0679	Auxin Efflux Carrier
M1S56_16930	COG1902	pentaerythritol trinitrate reductase activity
M1S56_16950	COG2094	Belongs to the DNA glycosylase MPG family
M1S56_16975	COG1217	gtp-binding protein TYPA
M1S56_16980	COG2233	PERMEase
M1S56_16990	COG0833	amino acid
M1S56_16995	COG1690	Belongs to the RtcB family
M1S56_17005	COG2885	chlorophyll binding
M1S56_17005	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M1S56_17015	COG0183	Belongs to the thiolase family
M1S56_17035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M1S56_17055	COG2207	Transcriptional regulator
M1S56_17060	COG0183	Belongs to the thiolase family
M1S56_17090	COG1272	protein, Hemolysin III
M1S56_17095	COG0477	Major facilitator Superfamily
M1S56_17110	COG0450	alkyl hydroperoxide reductase
M1S56_17130	COG0285	dihydrofolate synthase activity
M1S56_17180	COG2096	Adenosyltransferase
M1S56_17200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M1S56_17205	COG0745	RESPONSE REGULATOR receiver
M1S56_17210	COG2205	protein histidine kinase activity
M1S56_17220	COG1960	acyl-CoA dehydrogenase activity
M1S56_17225	COG1960	acyl-CoA dehydrogenase activity
M1S56_17230	COG0583	DNA-binding transcription factor activity
M1S56_17235	COG0625	glutathione transferase activity
M1S56_17310	COG0438	transferase activity, transferring glycosyl groups
M1S56_17315	COG0463	Glycosyl transferase, family 2
M1S56_17320	COG0726	polysaccharide deacetylase
M1S56_17340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M1S56_17345	COG2205	protein histidine kinase activity
M1S56_17375	COG1862	Preprotein translocase
M1S56_17385	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M1S56_17390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M1S56_17400	COG3781	membrane
M1S56_17405	COG0613	PHP domain protein
M1S56_17415	COG2350	Protein conserved in bacteria
M1S56_17445	COG1607	acyl-coa hydrolase
M1S56_17505	COG2199	diguanylate cyclase activity
M1S56_17515	COG1408	metallophosphoesterase
M1S56_17520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M1S56_17530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M1S56_17550	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M1S56_17555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M1S56_17570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M1S56_17580	COG2969	positive regulation of protein catabolic process
M1S56_17600	COG1960	acyl-CoA dehydrogenase activity
M1S56_17605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M1S56_17620	COG1309	transcriptional regulator
M1S56_17625	COG1960	acyl-CoA dehydrogenase activity
M1S56_17680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M1S56_17690	COG1846	Transcriptional regulator
M1S56_17695	COG1764	response to oxidative stress
M1S56_17735	COG0037	tRNA processing
M1S56_17745	COG0248	Ppx GppA phosphatase
M1S56_17775	COG0072	phenylalanine-tRNA ligase activity
M1S56_17820	COG1238	metal cluster binding
M1S56_17825	COG0625	glutathione transferase activity
M1S56_17840	COG0318	PFAM AMP-dependent synthetase and ligase
M1S56_17845	COG3028	Belongs to the UPF0307 family
M1S56_17850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M1S56_17870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M1S56_17875	COG0617	tRNA 3'-terminal CCA addition
M1S56_17880	COG1555	photosystem II stabilization
M1S56_17885	COG3956	TIGRFAM MazG family protein
M1S56_17895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M1S56_17915	COG0784	Response regulator, receiver
M1S56_17915	COG2205	protein histidine kinase activity
M1S56_17915	COG5002	protein histidine kinase activity
M1S56_17920	COG1024	Enoyl-CoA hydratase
M1S56_17925	COG2084	Dehydrogenase
M1S56_17930	COG3622	Belongs to the hyi family
M1S56_17960	COG0697	spore germination
M1S56_17970	COG2814	Major facilitator Superfamily
M1S56_17975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M1S56_17985	COG0583	DNA-binding transcription factor activity
M1S56_17995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M1S56_18010	COG0084	hydrolase, TatD family'
M1S56_18025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M1S56_18055	COG0440	acetolactate synthase activity
M1S56_18060	COG0028	Belongs to the TPP enzyme family
M1S56_18085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M1S56_18090	COG0577	efflux transmembrane transporter activity
M1S56_18090	COG1136	(ABC) transporter
M1S56_18095	COG1538	Outer membrane efflux protein
M1S56_18110	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M1S56_18115	COG1162	GTPase activity
M1S56_18125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M1S56_18145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M1S56_18150	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_18190	COG2986	histidine ammonia-lyase
M1S56_18205	COG0318	PFAM AMP-dependent synthetase and ligase
M1S56_18215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S56_18260	COG1426	Protein conserved in bacteria
M1S56_18295	COG0793	Belongs to the peptidase S41A family
M1S56_18310	COG2267	carboxylic ester hydrolase activity
M1S56_18320	COG1012	belongs to the aldehyde dehydrogenase family
M1S56_18325	COG3265	gluconokinase activity
M1S56_18335	COG0800	Aldolase
M1S56_18345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M1S56_18350	COG0280	phosphate acetyltransferase
M1S56_18350	COG0857	belongs to the CobB CobQ family
M1S56_18355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S56_18355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
M1S56_18375	COG0740	serine-type endopeptidase activity
M1S56_18385	COG4774	siderophore transport
M1S56_18395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M1S56_18405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M1S56_18405	COG2813	Specifically methylates the guanine in position
M1S56_18505	COG0788	formyltetrahydrofolate deformylase activity
M1S56_18530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S56_18530	COG4651	solute:proton antiporter activity
M1S56_18550	COG0724	RNA recognition motif
M1S56_18555	COG0210	DNA helicase
M1S56_18580	COG1733	regulation of RNA biosynthetic process
M1S56_18590	COG2900	Belongs to the SlyX family
M1S56_18595	COG0488	(ABC) transporter
M1S56_18600	COG1280	lysine exporter protein (LysE YggA)
M1S56_18605	COG1560	Kdo2-lipid A biosynthetic process
M1S56_18615	COG1301	dicarboxylic acid transport
M1S56_18670	COG0473	3-isopropylmalate dehydrogenase activity
M1S56_18735	COG0583	DNA-binding transcription factor activity
M1S56_18745	COG0625	glutathione transferase activity
M1S56_18750	COG2378	regulation of single-species biofilm formation
M1S56_18755	COG0546	phosphoglycolate phosphatase activity
M1S56_18765	COG1530	ribonuclease E activity
M1S56_18770	COG0318	PFAM AMP-dependent synthetase and ligase
M1S56_18785	COG0583	DNA-binding transcription factor activity
M1S56_18790	COG4221	oxidoreductase activity
M1S56_18795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M1S56_18805	COG0534	Mate efflux family protein
M1S56_18820	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M1S56_18860	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M1S56_18865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M1S56_18880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M1S56_18890	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
M1S56_18890	COG0644	oxidoreductase
M1S56_18895	COG0425	Belongs to the sulfur carrier protein TusA family
M1S56_18900	COG4535	Mg2 and Co2 transporter CorC
M1S56_18910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M1S56_18930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M1S56_18935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M1S56_18935	COG0475	glutathione-regulated potassium exporter activity
M1S56_18940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M1S56_18950	COG0484	heat shock protein binding
M1S56_18955	COG0789	Transcriptional regulator
M1S56_18960	COG0598	Magnesium transport protein CorA
M1S56_18975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M1S56_18980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M1S56_18985	COG1074	ATP-dependent DNA helicase activity
M1S56_18990	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M1S56_19010	COG2226	methyltransferase
M1S56_19025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M1S56_19030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M1S56_19045	COG2111	Na H antiporter
M1S56_19045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M1S56_19050	COG1006	Multisubunit Na H antiporter MnhC subunit
M1S56_19055	COG0651	ATP synthesis coupled electron transport
M1S56_19060	COG1863	multisubunit Na H antiporter MnhE subunit
M1S56_19065	COG2212	antiporter activity
M1S56_19070	COG1320	monovalent cation:proton antiporter activity
M1S56_19085	COG0195	Participates in both transcription termination and antitermination
M1S56_19145	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M1S56_19150	COG0237	dephospho-CoA kinase activity
M1S56_19160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M1S56_19175	COG0497	DNA recombination
M1S56_19185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M1S56_19215	COG2169	Transcriptional regulator
M1S56_19215	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M1S56_19220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M1S56_19285	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M1S56_19300	COG0326	Molecular chaperone. Has ATPase activity
M1S56_19315	COG2056	Na+-H+ antiporter family
M1S56_19320	COG0596	Alpha beta hydrolase
M1S56_19415	COG0546	phosphoglycolate phosphatase activity
M1S56_19420	COG1716	ATPase activity
M1S56_19465	COG0181	hydroxymethylbilane synthase activity
M1S56_19475	COG3275	phosphorelay sensor kinase activity
M1S56_19495	COG1538	Outer membrane efflux protein
M1S56_19500	COG0697	spore germination
M1S56_19525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M1S56_19530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M1S56_19535	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M1S56_19540	COG0772	Belongs to the SEDS family
M1S56_19565	COG4974	Belongs to the 'phage' integrase family
M1S56_19570	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S56_19580	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M1S56_19590	COG2197	response regulator
M1S56_19605	COG0793	Belongs to the peptidase S41A family
M1S56_19610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M1S56_19615	COG0795	lipopolysaccharide-transporting ATPase activity
M1S56_19655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S56_19655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M1S56_19665	COG0004	ammonium transporteR
M1S56_19670	COG0347	Belongs to the P(II) protein family
M1S56_19690	COG0659	secondary active sulfate transmembrane transporter activity
M1S56_19695	COG0589	response to stress
M1S56_19735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S56_19780	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
M1S56_19850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M1S56_19860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M1S56_19880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M1S56_19895	COG0318	PFAM AMP-dependent synthetase and ligase
M1S56_19905	COG0477	Major facilitator Superfamily
M1S56_19910	COG2860	membrane
M1S56_19920	COG1253	flavin adenine dinucleotide binding
M1S56_19940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M1S56_19980	COG0655	NAD(P)H dehydrogenase (quinone) activity
M1S56_19990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M1S56_20060	COG0758	DNA mediated transformation
M1S56_20070	COG0697	spore germination
M1S56_20075	COG1309	transcriptional regulator
M1S56_20090	COG0386	Belongs to the glutathione peroxidase family
M1S56_20155	COG1121	(ABC) transporter
M1S56_20160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M1S56_20165	COG1280	lysine exporter protein (LysE YggA)
M1S56_20170	COG2837	iron assimilation
M1S56_20180	COG0281	malic enzyme
M1S56_20225	COG0519	Catalyzes the synthesis of GMP from XMP
M1S56_20225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M1S56_20230	COG4399	Belongs to the UPF0754 family
M1S56_20235	COG2259	Doxx family
M1S56_20240	COG0586	Pfam SNARE associated Golgi protein
M1S56_20255	COG1192	Involved in chromosome partitioning
M1S56_20265	COG0271	Belongs to the BolA IbaG family
M1S56_20285	COG2267	carboxylic ester hydrolase activity
M1S56_20305	COG3321	synthase
M1S56_20305	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
M1S56_20305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M1S56_20305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M1S56_20310	COG1960	acyl-CoA dehydrogenase activity
M1S56_20320	COG2197	response regulator
M1S56_20330	COG3916	Acyl-homoserine-lactone synthase
M1S56_20335	COG0477	Major facilitator Superfamily
M1S56_20340	COG1024	Enoyl-CoA hydratase
M1S56_20345	COG1024	Enoyl-CoA hydratase
M1S56_20350	COG1960	acyl-CoA dehydrogenase activity
M1S56_20355	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M1S56_20375	COG1113	amino acid transport
M1S56_20380	COG1113	amino acid transport
M1S56_20385	COG0251	oxidation-reduction process
M1S56_20425	COG0564	pseudouridine synthase activity
M1S56_20485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M1S56_20500	COG1802	Transcriptional regulator
M1S56_20510	COG1448	Aminotransferase
M1S56_20515	COG0277	FAD linked oxidase domain protein
M1S56_20525	COG2186	Transcriptional regulator
M1S56_20535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M1S56_20540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M1S56_20555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M1S56_20560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M1S56_20585	COG2244	polysaccharide biosynthetic process
M1S56_20590	COG1083	cytidylyl-transferase
M1S56_20595	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M1S56_20605	COG2089	acid synthase
M1S56_20610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M1S56_20615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M1S56_20625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
M1S56_20630	COG1596	polysaccharide export
M1S56_20655	COG0728	peptidoglycan biosynthetic process
M1S56_20660	COG3023	N-Acetylmuramoyl-L-alanine amidase
M1S56_20720	COG0546	phosphoglycolate phosphatase activity
M1S56_20725	COG1028	Short-chain dehydrogenase reductase Sdr
M1S56_20745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S56_20750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M1S56_20755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M1S56_20760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M1S56_20765	COG1116	anion transmembrane transporter activity
M1S56_20770	COG1309	transcriptional regulator
M1S56_20775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M1S56_20785	COG0196	riboflavin kinase activity
M1S56_20790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M1S56_20800	COG1047	Peptidyl-prolyl cis-trans
M1S56_20840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M1S56_20845	COG0657	acetylesterase activity
M1S56_20865	COG0583	DNA-binding transcription factor activity
M1S56_20895	COG2951	lytic endotransglycosylase activity
M1S56_20900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M1S56_20915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M1S56_20925	COG0671	phosphoesterase, PA-phosphatase related
M1S56_20930	COG0861	Integral membrane protein TerC family
M1S56_20940	COG0754	glutathionylspermidine amidase activity
M1S56_20950	COG0402	S-adenosylhomocysteine deaminase activity
M1S56_20965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M1S56_20970	COG1230	cation diffusion facilitator family transporter
M1S56_20985	COG0706	membrane insertase activity