locus-tag	class	description
A388_00001	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A388_00002	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A388_00003	COG0596	Alpha beta hydrolase
A388_00008	COG0488	(ABC) transporter
A388_00009	COG0586	Pfam SNARE associated Golgi protein
A388_00011	COG0187	DNA topoisomerase II activity
A388_00013	COG0592	DNA-directed DNA polymerase activity
A388_00015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A388_00018	COG0706	membrane insertase activity
A388_00021	COG1230	cation diffusion facilitator family transporter
A388_00022	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A388_00026	COG0402	S-adenosylhomocysteine deaminase activity
A388_00028	COG0754	glutathionylspermidine amidase activity
A388_00030	COG0861	Integral membrane protein TerC family
A388_00031	COG0671	phosphoesterase, PA-phosphatase related
A388_00033	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A388_00036	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A388_00043	COG0583	DNA-binding transcription factor activity
A388_00048	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A388_00053	COG1047	Peptidyl-prolyl cis-trans
A388_00055	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A388_00056	COG0196	riboflavin kinase activity
A388_00058	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A388_00059	COG1309	transcriptional regulator
A388_00060	COG1116	anion transmembrane transporter activity
A388_00061	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A388_00062	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A388_00063	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A388_00064	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A388_00068	COG1028	Short-chain dehydrogenase reductase Sdr
A388_00069	COG0546	phosphoglycolate phosphatase activity
A388_00080	COG3023	N-Acetylmuramoyl-L-alanine amidase
A388_00081	COG0728	peptidoglycan biosynthetic process
A388_00086	COG1596	polysaccharide export
A388_00087	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A388_00089	COG5039	Polysaccharide pyruvyl transferase
A388_00090	COG1216	Glycosyl transferase, family 2
A388_00094	COG0438	transferase activity, transferring glycosyl groups
A388_00095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A388_00097	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A388_00099	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A388_00102	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A388_00103	COG2194	sulfuric ester hydrolase activity
A388_00106	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A388_00108	COG2186	Transcriptional regulator
A388_00110	COG0277	FAD linked oxidase domain protein
A388_00111	COG1448	Aminotransferase
A388_00112	COG1802	Transcriptional regulator
A388_00115	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A388_00123	COG0564	pseudouridine synthase activity
A388_00128	COG1522	sequence-specific DNA binding
A388_00131	COG0251	oxidation-reduction process
A388_00132	COG1113	amino acid transport
A388_00133	COG1113	amino acid transport
A388_00137	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A388_00138	COG1960	acyl-CoA dehydrogenase activity
A388_00139	COG1024	Enoyl-CoA hydratase
A388_00140	COG1024	Enoyl-CoA hydratase
A388_00141	COG0477	Major facilitator Superfamily
A388_00142	COG2197	response regulator
A388_00147	COG0271	Belongs to the BolA IbaG family
A388_00149	COG1192	Involved in chromosome partitioning
A388_00152	COG0586	Pfam SNARE associated Golgi protein
A388_00153	COG2259	Doxx family
A388_00154	COG4399	Belongs to the UPF0754 family
A388_00155	COG0519	Catalyzes the synthesis of GMP from XMP
A388_00155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A388_00164	COG0281	malic enzyme
A388_00165	COG2837	iron assimilation
A388_00166	COG1280	lysine exporter protein (LysE YggA)
A388_00167	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A388_00168	COG1121	(ABC) transporter
A388_00181	COG0386	Belongs to the glutathione peroxidase family
A388_00184	COG1309	transcriptional regulator
A388_00185	COG0697	spore germination
A388_00187	COG0758	DNA mediated transformation
A388_00194	COG1309	transcriptional regulator
A388_00198	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A388_00200	COG0655	NAD(P)H dehydrogenase (quinone) activity
A388_00207	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A388_00209	COG0477	Major facilitator Superfamily
A388_00211	COG1253	flavin adenine dinucleotide binding
A388_00213	COG2860	membrane
A388_00214	COG0477	Major facilitator Superfamily
A388_00216	COG0318	PFAM AMP-dependent synthetase and ligase
A388_00219	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A388_00223	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A388_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A388_00232	COG2072	flavoprotein involved in K transport
A388_00233	COG0492	ferredoxin-NADP+ reductase activity
A388_00234	COG0431	NADPH-dependent FMN reductase
A388_00235	COG0798	PFAM Bile acid sodium symporter
A388_00237	COG0640	Transcriptional regulator
A388_00240	COG0789	Transcriptional regulator
A388_00245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A388_00251	COG3316	Transposase and inactivated derivatives
A388_00257	COG0789	Transcriptional regulator
A388_00260	COG0697	spore germination
A388_00261	COG3316	Transposase and inactivated derivatives
A388_00263	COG1662	PFAM IS1 transposase
A388_00268	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A388_00269	COG3316	Transposase and inactivated derivatives
A388_00275	COG2814	Major facilitator Superfamily
A388_00276	COG0583	DNA-binding transcription factor activity
A388_00280	COG0667	Aldo Keto reductase
A388_00284	COG1733	regulation of RNA biosynthetic process
A388_00287	COG1733	regulation of RNA biosynthetic process
A388_00288	COG2249	NAD(P)H dehydrogenase (quinone) activity
A388_00290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A388_00301	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A388_00309	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A388_00315	COG0427	acetyl-CoA hydrolase
A388_00317	COG0745	RESPONSE REGULATOR receiver
A388_00319	COG0659	secondary active sulfate transmembrane transporter activity
A388_00320	COG4221	oxidoreductase activity
A388_00322	COG0488	(ABC) transporter
A388_00335	COG0833	amino acid
A388_00344	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A388_00345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A388_00348	COG2226	methyltransferase
A388_00358	COG0067	glutamate synthase
A388_00358	COG0069	glutamate synthase activity
A388_00358	COG0070	glutamate synthase
A388_00359	COG0493	'glutamate synthase
A388_00361	COG1704	LemA family
A388_00362	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A388_00365	COG3307	-O-antigen
A388_00369	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A388_00371	COG0194	GDP metabolic process
A388_00381	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A388_00385	COG5380	lipid catabolic process
A388_00386	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A388_00391	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A388_00392	COG0277	FAD linked oxidase domain protein
A388_00394	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A388_00395	COG2249	NAD(P)H dehydrogenase (quinone) activity
A388_00398	COG1289	transmembrane transporter activity
A388_00400	COG0628	permease
A388_00407	COG0833	amino acid
A388_00408	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A388_00409	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A388_00411	COG1012	belongs to the aldehyde dehydrogenase family
A388_00419	COG0583	DNA-binding transcription factor activity
A388_00429	COG0517	IMP dehydrogenase activity
A388_00430	COG1983	PspC domain protein
A388_00432	COG1960	acyl-CoA dehydrogenase activity
A388_00435	COG0408	coproporphyrinogen oxidase activity
A388_00439	COG0513	Belongs to the DEAD box helicase family
A388_00441	COG1127	ABC transporter
A388_00442	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A388_00444	COG2854	intermembrane phospholipid transfer
A388_00446	COG0598	Magnesium transport protein CorA
A388_00448	COG0494	nUDIX hydrolase
A388_00449	COG1040	competence protein
A388_00450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A388_00454	COG1946	Acyl-CoA thioesterase
A388_00455	COG1301	dicarboxylic acid transport
A388_00458	COG1959	2 iron, 2 sulfur cluster binding
A388_00459	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A388_00459	COG1017	nitric oxide dioxygenase activity
A388_00460	COG0433	COG0433 Predicted ATPase
A388_00461	COG0626	cystathionine gamma-synthase activity
A388_00485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A388_00487	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A388_00492	COG1960	acyl-CoA dehydrogenase activity
A388_00493	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A388_00500	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A388_00501	COG0339	signal peptide processing
A388_00502	COG0557	exoribonuclease II activity
A388_00507	COG2826	transposase and inactivated derivatives, IS30 family
A388_00512	COG0179	Fumarylacetoacetate (FAA) hydrolase
A388_00513	COG2169	Transcriptional regulator
A388_00514	COG0697	spore germination
A388_00515	COG1295	ribonuclease BN
A388_00522	COG1702	phosphate starvation-inducible protein PhoH
A388_00524	COG0739	heme binding
A388_00524	COG0741	lytic transglycosylase activity
A388_00524	COG1196	nuclear chromosome segregation
A388_00530	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A388_00531	COG1183	phosphatidylcholine synthase activity
A388_00537	COG1960	acyl-CoA dehydrogenase activity
A388_00538	COG1309	transcriptional regulator
A388_00541	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A388_00542	COG1960	acyl-CoA dehydrogenase activity
A388_00546	COG2969	positive regulation of protein catabolic process
A388_00548	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A388_00551	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A388_00552	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A388_00556	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A388_00558	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A388_00559	COG1408	metallophosphoesterase
A388_00561	COG2199	diguanylate cyclase activity
A388_00567	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A388_00567	COG3453	Protein conserved in bacteria
A388_00570	COG1607	acyl-coa hydrolase
A388_00576	COG2350	Protein conserved in bacteria
A388_00578	COG0613	PHP domain protein
A388_00579	COG3781	membrane
A388_00581	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A388_00584	COG1862	Preprotein translocase
A388_00594	COG0629	single-stranded DNA binding
A388_00633	COG4695	Portal protein
A388_00634	COG2205	protein histidine kinase activity
A388_00635	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A388_00639	COG0726	polysaccharide deacetylase
A388_00640	COG0463	Glycosyl transferase, family 2
A388_00641	COG0438	transferase activity, transferring glycosyl groups
A388_00654	COG1960	acyl-CoA dehydrogenase activity
A388_00655	COG1960	acyl-CoA dehydrogenase activity
A388_00657	COG2205	protein histidine kinase activity
A388_00658	COG0745	RESPONSE REGULATOR receiver
A388_00659	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A388_00663	COG2096	Adenosyltransferase
A388_00664	COG4206	TonB-dependent receptor
A388_00666	COG0133	tryptophan synthase activity
A388_00673	COG0285	dihydrofolate synthase activity
A388_00677	COG0450	alkyl hydroperoxide reductase
A388_00680	COG0477	Major facilitator Superfamily
A388_00681	COG1272	protein, Hemolysin III
A388_00687	COG0183	Belongs to the thiolase family
A388_00688	COG2207	Transcriptional regulator
A388_00692	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A388_00696	COG0183	Belongs to the thiolase family
A388_00698	COG2885	chlorophyll binding
A388_00698	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A388_00700	COG1690	Belongs to the RtcB family
A388_00701	COG0833	amino acid
A388_00703	COG2233	PERMEase
A388_00709	COG2094	Belongs to the DNA glycosylase MPG family
A388_00710	COG4772	TonB-dependent receptor
A388_00711	COG1902	pentaerythritol trinitrate reductase activity
A388_00714	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A388_00715	COG0354	folic acid binding
A388_00717	COG3189	MarR family transcriptional regulator
A388_00718	COG2824	Alkylphosphonate utilization operon protein PhnA
A388_00719	COG3422	double-strand break repair
A388_00727	COG0840	transmembrane signaling receptor activity
A388_00730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A388_00733	COG5510	response to toxic substance
A388_00735	COG2832	Protein of unknown function (DUF454)
A388_00736	COG1376	ErfK ybiS ycfS ynhG family protein
A388_00746	COG1289	transmembrane transporter activity
A388_00747	COG2814	Major facilitator Superfamily
A388_00750	COG1115	amino acid carrier protein
A388_00751	COG1752	Esterase of the alpha-beta hydrolase superfamily
A388_00752	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A388_00753	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A388_00758	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A388_00760	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A388_00761	COG1077	Cell shape determining protein MreB Mrl
A388_00762	COG1792	Involved in formation and maintenance of cell shape
A388_00763	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A388_00764	COG0424	maF-like protein
A388_00765	COG1530	ribonuclease E activity
A388_00767	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A388_00771	COG2249	NAD(P)H dehydrogenase (quinone) activity
A388_00776	COG2207	Transcriptional regulator
A388_00840	COG0739	heme binding
A388_00840	COG1196	nuclear chromosome segregation
A388_00840	COG0741	lytic transglycosylase activity
A388_00852	COG0582	viral genome integration into host DNA
A388_00854	COG1113	amino acid transport
A388_00855	COG2828	Protein conserved in bacteria
A388_00856	COG0142	geranyltranstransferase activity
A388_00857	COG2315	Protein conserved in bacteria
A388_00860	COG1752	Esterase of the alpha-beta hydrolase superfamily
A388_00864	COG2194	sulfuric ester hydrolase activity
A388_00865	COG0745	RESPONSE REGULATOR receiver
A388_00866	COG0642	Histidine kinase
A388_00868	COG0004	ammonium transporteR
A388_00869	COG0583	DNA-binding transcription factor activity
A388_00873	COG0525	valine-tRNA ligase activity
A388_00875	COG1028	Short-chain dehydrogenase reductase Sdr
A388_00877	COG0393	Putative heavy-metal-binding
A388_00878	COG0393	Putative heavy-metal-binding
A388_00879	COG1538	Outer membrane efflux protein
A388_00883	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A388_00884	COG0671	phosphoesterase, PA-phosphatase related
A388_00889	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A388_00892	COG1648	precorrin-2 dehydrogenase activity
A388_00892	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A388_00893	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A388_00894	COG1733	regulation of RNA biosynthetic process
A388_00896	COG0531	amino acid
A388_00899	COG0321	lipoyl(octanoyl) transferase activity
A388_00900	COG2921	Belongs to the UPF0250 family
A388_00907	COG2009	succinate dehydrogenase
A388_00908	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A388_00909	COG1053	succinate dehydrogenase
A388_00910	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A388_00913	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A388_00919	COG2354	Protein conserved in bacteria
A388_00920	COG2321	neutral zinc metallopeptidase
A388_00925	COG2843	Capsule synthesis protein
A388_00928	COG0589	response to stress
A388_00932	COG0505	Belongs to the CarA family
A388_00937	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A388_00938	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A388_00948	COG0477	Major facilitator Superfamily
A388_00949	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A388_00953	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A388_00958	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A388_00959	COG0584	glycerophosphoryl diester phosphodiesterase
A388_00963	COG0741	lytic transglycosylase activity
A388_00967	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A388_00970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A388_00979	COG0778	Nitroreductase
A388_00982	COG1929	Belongs to the glycerate kinase type-1 family
A388_00983	COG0243	molybdopterin cofactor binding
A388_00984	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A388_00985	COG3339	Conserved Protein
A388_00987	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A388_00990	COG1113	amino acid transport
A388_00992	COG0019	diaminopimelate decarboxylase activity
A388_00994	COG2267	carboxylic ester hydrolase activity
A388_00995	COG1280	lysine exporter protein (LysE YggA)
A388_00996	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A388_01002	COG0463	Glycosyl transferase, family 2
A388_01006	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A388_01013	COG4591	ABC-type transport system involved in lipoprotein release permease component
A388_01014	COG1136	(ABC) transporter
A388_01015	COG0658	competence protein
A388_01015	COG2333	competence protein COMEC
A388_01017	COG0616	signal peptide processing
A388_01017	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A388_01018	COG0596	Alpha beta hydrolase
A388_01019	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A388_01021	COG0628	permease
A388_01028	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A388_01032	COG0823	Involved in the tonB-independent uptake of proteins
A388_01036	COG0824	Thioesterase
A388_01037	COG1473	amidohydrolase
A388_01041	COG0047	phosphoribosylformylglycinamidine synthase activity
A388_01041	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A388_01042	COG2814	Major facilitator Superfamily
A388_01043	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A388_01044	COG1024	Enoyl-CoA hydratase
A388_01045	COG1056	cytidyltransferase-related domain
A388_01045	COG1051	belongs to the nudix hydrolase family
A388_01047	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A388_01050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A388_01053	COG4625	pathogenesis
A388_01054	COG0583	DNA-binding transcription factor activity
A388_01055	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A388_01056	COG4208	sulfate ABC transporter
A388_01057	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A388_01059	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A388_01060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A388_01061	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A388_01065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A388_01068	COG0681	Belongs to the peptidase S26 family
A388_01071	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A388_01073	COG1381	Involved in DNA repair and RecF pathway recombination
A388_01074	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A388_01076	COG4221	oxidoreductase activity
A388_01085	COG0556	nucleotide-excision repair
A388_01096	COG2070	2-Nitropropane dioxygenase
A388_01102	COG1215	transferase activity, transferring glycosyl groups
A388_01105	COG0415	Belongs to the DNA photolyase family
A388_01107	COG1252	NADH dehydrogenase
A388_01108	COG1686	Belongs to the peptidase S11 family
A388_01111	COG1187	pseudouridine synthase activity
A388_01116	COG0477	Major facilitator Superfamily
A388_01117	COG0583	DNA-binding transcription factor activity
A388_01120	COG0612	Peptidase, M16
A388_01126	COG1203	CRISPR-associated helicase, Cas3
A388_01131	COG0352	thiamine-phosphate diphosphorylase activity
A388_01138	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A388_01141	COG1309	transcriptional regulator
A388_01143	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A388_01144	COG0076	glutamate decarboxylase activity
A388_01146	COG1522	sequence-specific DNA binding
A388_01147	COG3961	Belongs to the TPP enzyme family
A388_01148	COG1113	amino acid transport
A388_01149	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A388_01150	COG0573	inorganic phosphate transmembrane transporter activity
A388_01152	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A388_01153	COG0616	signal peptide processing
A388_01160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A388_01161	COG1686	Belongs to the peptidase S11 family
A388_01166	COG0583	DNA-binding transcription factor activity
A388_01167	COG1067	ATP-dependent peptidase activity
A388_01172	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A388_01176	COG1966	Carbon starvation protein
A388_01177	COG2879	small protein
A388_01179	COG0583	DNA-binding transcription factor activity
A388_01180	COG0006	proline dipeptidase activity
A388_01181	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A388_01182	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A388_01185	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A388_01186	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A388_01186	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A388_01198	COG1741	Belongs to the pirin family
A388_01200	COG2964	Protein conserved in bacteria
A388_01203	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A388_01206	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A388_01207	COG4605	iron ion homeostasis
A388_01208	COG4604	ABC transporter, ATP-binding protein
A388_01209	COG4607	ABC-type enterochelin transport system periplasmic component
A388_01210	COG4774	siderophore transport
A388_01212	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A388_01213	COG1021	2,3-dihydroxybenzoate-AMP ligase
A388_01214	COG1535	isochorismatase
A388_01214	COG3433	isochorismatase activity
A388_01217	COG1132	(ABC) transporter
A388_01219	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A388_01221	COG1169	isochorismate synthase
A388_01224	COG3739	integral membrane protein
A388_01228	COG2826	transposase and inactivated derivatives, IS30 family
A388_01231	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A388_01237	COG0308	aminopeptidase N
A388_01238	COG0512	Glutamine amidotransferase of anthranilate synthase
A388_01240	COG3104	oligopeptide transport
A388_01243	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A388_01250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A388_01251	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A388_01252	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A388_01256	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A388_01257	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A388_01258	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A388_01261	COG1960	acyl-CoA dehydrogenase activity
A388_01262	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A388_01263	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A388_01266	COG2223	nitrite transmembrane transporter activity
A388_01269	COG0024	Methionine aminopeptidase
A388_01270	COG0052	Belongs to the universal ribosomal protein uS2 family
A388_01273	COG2207	Transcriptional regulator
A388_01278	COG2951	lytic endotransglycosylase activity
A388_01279	COG0772	Belongs to the SEDS family
A388_01282	COG0842	Transport permease protein
A388_01283	COG1131	(ABC) transporter
A388_01284	COG0582	viral genome integration into host DNA
A388_01305	COG0305	Participates in initiation and elongation during chromosome replication
A388_01326	COG5410	chromosome segregation
A388_01347	COG3561	AntA/AntB antirepressor
A388_01369	COG1538	Outer membrane efflux protein
A388_01371	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A388_01374	COG4215	(ABC) transporter
A388_01375	COG4160	amino acid transport
A388_01376	COG4598	ABC transporter
A388_01378	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A388_01380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A388_01383	COG1720	tRNA m6t6A37 methyltransferase activity
A388_01387	COG0745	RESPONSE REGULATOR receiver
A388_01388	COG0642	Histidine kinase
A388_01390	COG0494	nUDIX hydrolase
A388_01392	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A388_01393	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A388_01394	COG3139	Protein of unknown function (DUF1315)
A388_01395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A388_01396	COG1301	dicarboxylic acid transport
A388_01397	COG1960	acyl-CoA dehydrogenase activity
A388_01398	COG2819	hydrolase of the alpha beta superfamily
A388_01400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A388_01402	COG2195	Cleaves the N-terminal amino acid of tripeptides
A388_01403	COG1234	tRNA 3'-trailer cleavage
A388_01408	COG2363	Small membrane protein
A388_01412	COG0513	Belongs to the DEAD box helicase family
A388_01414	COG0778	Nitroreductase
A388_01420	COG1286	toxin biosynthetic process
A388_01425	COG4783	chaperone-mediated protein folding
A388_01426	COG1610	YqeY-like protein
A388_01427	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A388_01443	COG2995	paraquat-inducible protein a
A388_01444	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A388_01444	COG3008	intermembrane lipid transfer
A388_01446	COG2351	hydroxyisourate hydrolase activity
A388_01454	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A388_01456	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A388_01457	COG0642	Histidine kinase
A388_01458	COG0745	RESPONSE REGULATOR receiver
A388_01462	COG1794	racemase activity, acting on amino acids and derivatives
A388_01468	COG1301	dicarboxylic acid transport
A388_01470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A388_01471	COG2011	ABC-type metal ion transport system permease component
A388_01472	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A388_01473	COG1464	Belongs to the NlpA lipoprotein family
A388_01474	COG0151	Belongs to the GarS family
A388_01475	COG0138	bifunctional purine biosynthesis protein purh
A388_01476	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A388_01482	COG2308	Evidence 4 Homologs of previously reported genes of
A388_01484	COG1305	Transglutaminase-like
A388_01486	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A388_01487	COG0305	Participates in initiation and elongation during chromosome replication
A388_01492	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A388_01494	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A388_01495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A388_01500	COG0726	polysaccharide deacetylase
A388_01500	COG1649	PFAM Uncharacterised BCR, COG1649
A388_01501	COG1215	transferase activity, transferring glycosyl groups
A388_01502	COG3658	cytochrome
A388_01504	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A388_01507	COG0583	DNA-binding transcription factor activity
A388_01511	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A388_01512	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A388_01515	COG1960	acyl-CoA dehydrogenase activity
A388_01516	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A388_01517	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A388_01522	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A388_01523	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A388_01525	COG2205	protein histidine kinase activity
A388_01526	COG0745	RESPONSE REGULATOR receiver
A388_01527	COG0174	glutamine synthetase
A388_01531	COG0729	surface antigen
A388_01536	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A388_01537	COG2814	Major facilitator Superfamily
A388_01540	COG0583	DNA-binding transcription factor activity
A388_01543	COG1187	pseudouridine synthase activity
A388_01547	COG0802	atpase or kinase
A388_01548	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A388_01550	COG1923	regulation of RNA biosynthetic process
A388_01551	COG0697	spore germination
A388_01556	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A388_01556	COG0519	Catalyzes the synthesis of GMP from XMP
A388_01557	COG4302	ethanolamine ammonia-lyase activity
A388_01558	COG4303	Ethanolamine ammonia lyase large subunit
A388_01559	COG0531	amino acid
A388_01563	COG1454	alcohol dehydrogenase
A388_01564	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A388_01569	COG0308	aminopeptidase N
A388_01577	COG1605	Chorismate mutase
A388_01580	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A388_01582	COG2826	transposase and inactivated derivatives, IS30 family
A388_01584	COG1309	transcriptional regulator
A388_01586	COG0668	transmembrane transport
A388_01592	COG4773	Receptor
A388_01596	COG0488	(ABC) transporter
A388_01597	COG0589	response to stress
A388_01601	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A388_01603	COG3135	benzoate transporter
A388_01604	COG1522	sequence-specific DNA binding
A388_01607	COG0583	DNA-binding transcription factor activity
A388_01609	COG0183	Belongs to the thiolase family
A388_01615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A388_01618	COG0824	Thioesterase
A388_01619	COG1454	alcohol dehydrogenase
A388_01621	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A388_01625	COG0069	glutamate synthase activity
A388_01629	COG2814	Major facilitator Superfamily
A388_01632	COG0511	ligase activity, forming carbon-carbon bonds
A388_01635	COG1116	anion transmembrane transporter activity
A388_01635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A388_01636	COG0745	RESPONSE REGULATOR receiver
A388_01638	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A388_01638	COG2146	nitrite reductase [NAD(P)H] activity
A388_01639	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A388_01640	COG0243	molybdopterin cofactor binding
A388_01642	COG0243	molybdopterin cofactor binding
A388_01643	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A388_01646	COG0315	cyclic pyranopterin monophosphate synthase activity
A388_01646	COG0521	Mo-molybdopterin cofactor biosynthetic process
A388_01647	COG0303	'Molybdopterin
A388_01650	COG0697	spore germination
A388_01654	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A388_01655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A388_01666	COG2204	response regulator
A388_01667	COG3852	Histidine kinase
A388_01671	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A388_01672	COG0575	Belongs to the CDS family
A388_01679	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A388_01681	COG2137	regulation of response to DNA damage stimulus
A388_01683	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A388_01684	COG1011	Hydrolase
A388_01689	COG1522	sequence-specific DNA binding
A388_01691	COG1113	amino acid transport
A388_01694	COG0659	secondary active sulfate transmembrane transporter activity
A388_01695	COG2135	peptidase activity
A388_01698	COG5001	Diguanylate cyclase
A388_01698	COG3300	MHYT domain
A388_01702	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A388_01702	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A388_01702	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A388_01704	COG1105	Belongs to the carbohydrate kinase PfkB family
A388_01705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A388_01705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A388_01711	COG0024	Methionine aminopeptidase
A388_01712	COG0583	DNA-binding transcription factor activity
A388_01714	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A388_01715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A388_01716	COG0516	GMP reductase activity
A388_01716	COG0517	IMP dehydrogenase activity
A388_01721	COG0552	protein localization to endoplasmic reticulum
A388_01723	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A388_01725	COG4890	Cyd operon protein YbgT
A388_01726	COG1294	oxidase, subunit
A388_01730	COG1585	Membrane protein implicated in regulation of membrane protease activity
A388_01732	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A388_01733	COG4774	siderophore transport
A388_01736	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A388_01737	COG0569	domain protein
A388_01738	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A388_01744	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A388_01745	COG0542	response to heat
A388_01747	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A388_01750	COG0446	pyridine nucleotide-disulphide oxidoreductase
A388_01750	COG1902	pentaerythritol trinitrate reductase activity
A388_01759	COG2323	membrane
A388_01760	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A388_01762	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A388_01763	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A388_01764	COG0183	Belongs to the thiolase family
A388_01765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A388_01766	COG0596	Alpha beta hydrolase
A388_01767	COG2271	Major facilitator Superfamily
A388_01768	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A388_01769	COG3485	protocatechuate 3,4-dioxygenase
A388_01770	COG3485	protocatechuate 3,4-dioxygenase
A388_01771	COG0710	3-dehydroquinate dehydratase activity
A388_01772	COG3420	alginic acid biosynthetic process
A388_01773	COG3659	wide pore channel activity
A388_01774	COG4993	Dehydrogenase
A388_01776	COG2391	methyltransferase activity
A388_01779	COG1414	Transcriptional regulator
A388_01780	COG0583	DNA-binding transcription factor activity
A388_01781	COG1960	acyl-CoA dehydrogenase activity
A388_01786	COG2814	Major facilitator Superfamily
A388_01788	COG0154	amidase activity
A388_01792	COG4638	Rieske (2fe-2S)
A388_01794	COG1028	Short-chain dehydrogenase reductase Sdr
A388_01796	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A388_01798	COG3733	amine oxidase
A388_01800	COG1012	belongs to the aldehyde dehydrogenase family
A388_01802	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A388_01803	COG0183	Belongs to the thiolase family
A388_01804	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A388_01805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A388_01807	COG4829	muconolactone delta-isomerase
A388_01808	COG4948	Mandelate Racemase Muconate Lactonizing
A388_01809	COG0583	DNA-binding transcription factor activity
A388_01811	COG2186	Transcriptional regulator
A388_01815	COG1012	belongs to the aldehyde dehydrogenase family
A388_01818	COG1902	pentaerythritol trinitrate reductase activity
A388_01818	COG0446	pyridine nucleotide-disulphide oxidoreductase
A388_01826	COG1309	transcriptional regulator
A388_01828	COG1028	Short-chain dehydrogenase reductase Sdr
A388_01829	COG4689	acetoacetate decarboxylase
A388_01831	COG1902	pentaerythritol trinitrate reductase activity
A388_01836	COG1335	isochorismatase
A388_01837	COG0583	DNA-binding transcription factor activity
A388_01839	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A388_01839	COG0475	glutathione-regulated potassium exporter activity
A388_01841	COG1473	amidohydrolase
A388_01845	COG2826	transposase and inactivated derivatives, IS30 family
A388_01859	COG0583	DNA-binding transcription factor activity
A388_01862	COG1566	PFAM secretion protein HlyD family protein
A388_01865	COG1012	belongs to the aldehyde dehydrogenase family
A388_01868	COG0129	dihydroxy-acid dehydratase activity
A388_01870	COG0583	DNA-binding transcription factor activity
A388_01871	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A388_01873	COG2084	Dehydrogenase
A388_01874	COG2207	Transcriptional regulator
A388_01875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A388_01885	COG1073	alpha beta
A388_01887	COG1028	Short-chain dehydrogenase reductase Sdr
A388_01890	COG2207	Transcriptional regulator
A388_01892	COG2205	protein histidine kinase activity
A388_01893	COG0745	RESPONSE REGULATOR receiver
A388_01894	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A388_01895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A388_01896	COG1538	Outer membrane efflux protein
A388_01898	COG2072	flavoprotein involved in K transport
A388_01900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A388_01944	COG3539	Fimbrial protein
A388_01949	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A388_01951	COG0753	catalase activity
A388_01954	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A388_01966	COG3433	isochorismatase activity
A388_01966	COG1535	isochorismatase
A388_01967	COG1028	Short-chain dehydrogenase reductase Sdr
A388_01968	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A388_01969	COG4149	molybdate abc transporter
A388_01970	COG0725	ABC transporter, periplasmic molybdate-binding protein
A388_01972	COG4638	Rieske (2fe-2S)
A388_01973	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A388_01974	COG0543	2 iron, 2 sulfur cluster binding
A388_01974	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A388_01977	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A388_01979	COG1028	Short-chain dehydrogenase reductase Sdr
A388_01980	COG0412	Dienelactone hydrolase
A388_01982	COG2207	Transcriptional regulator
A388_01983	COG1028	Short-chain dehydrogenase reductase Sdr
A388_01984	COG2610	gluconate transmembrane transporter activity
A388_01986	COG0583	DNA-binding transcription factor activity
A388_01989	COG2031	fatty acid transporter
A388_01990	COG0183	Belongs to the thiolase family
A388_01991	COG0583	DNA-binding transcription factor activity
A388_01992	COG0583	DNA-binding transcription factor activity
A388_01995	COG1027	Aspartate ammonia-lyase
A388_01997	COG0477	Major facilitator Superfamily
A388_02001	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A388_02002	COG4521	taurine ABC transporter
A388_02007	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A388_02008	COG1733	regulation of RNA biosynthetic process
A388_02009	COG2207	Transcriptional regulator
A388_02009	COG3708	Transcriptional regulator
A388_02012	COG0730	response to heat
A388_02014	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A388_02014	COG3453	Protein conserved in bacteria
A388_02016	COG3781	membrane
A388_02017	COG1063	alcohol dehydrogenase
A388_02019	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A388_02020	COG0508	dehydrogenase complex catalyzes the overall conversion of
A388_02021	COG0022	dehydrogenase e1 component
A388_02022	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A388_02023	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A388_02026	COG2826	transposase and inactivated derivatives, IS30 family
A388_02028	COG3706	GGDEF domain
A388_02031	COG0133	tryptophan synthase activity
A388_02033	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A388_02040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A388_02045	COG2226	methyltransferase
A388_02056	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A388_02058	COG4773	Receptor
A388_02062	COG0730	response to heat
A388_02063	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A388_02066	COG0406	alpha-ribazole phosphatase activity
A388_02067	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A388_02070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A388_02076	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A388_02078	COG4264	IucA IucC family
A388_02079	COG4264	IucA IucC family
A388_02080	COG2814	Major facilitator Superfamily
A388_02083	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A388_02086	COG1960	acyl-CoA dehydrogenase activity
A388_02087	COG1960	acyl-CoA dehydrogenase activity
A388_02088	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A388_02089	COG2207	Transcriptional regulator
A388_02090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A388_02091	COG0776	regulation of translation
A388_02096	COG0822	iron-sulfur transferase activity
A388_02097	COG0316	Belongs to the HesB IscA family
A388_02103	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A388_02107	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A388_02108	COG0702	epimerase
A388_02115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A388_02117	COG0339	signal peptide processing
A388_02122	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A388_02126	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A388_02127	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A388_02133	COG0776	regulation of translation
A388_02137	COG0590	tRNA wobble adenosine to inosine editing
A388_02146	COG0084	hydrolase, TatD family'
A388_02150	COG1663	tetraacyldisaccharide 4'-kinase activity
A388_02151	COG1132	(ABC) transporter
A388_02153	COG0811	peptide transport
A388_02154	COG1475	DNA binding
A388_02155	COG1192	Involved in chromosome partitioning
A388_02157	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A388_02160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A388_02161	COG0191	fructose-bisphosphate aldolase activity
A388_02165	COG0424	maF-like protein
A388_02166	COG2850	peptidyl-arginine hydroxylation
A388_02168	COG0640	Transcriptional regulator
A388_02170	COG3619	membrane
A388_02171	COG3122	Protein conserved in bacteria
A388_02172	COG1132	(ABC) transporter
A388_02176	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A388_02177	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A388_02179	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A388_02179	COG0506	proline dehydrogenase activity
A388_02179	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A388_02180	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A388_02183	COG3698	Phosphodiester glycosidase
A388_02185	COG2353	YceI-like domain
A388_02187	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A388_02196	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A388_02196	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A388_02201	COG3539	Fimbrial protein
A388_02203	COG2826	transposase and inactivated derivatives, IS30 family
A388_02205	COG2826	transposase and inactivated derivatives, IS30 family
A388_02206	COG3121	Chaperone
A388_02211	COG0697	spore germination
A388_02215	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A388_02217	COG0583	DNA-binding transcription factor activity
A388_02222	COG2826	transposase and inactivated derivatives, IS30 family
A388_02223	COG1309	transcriptional regulator
A388_02226	COG1522	sequence-specific DNA binding
A388_02228	COG1126	abc transporter atp-binding protein
A388_02229	COG0765	amino acid transport
A388_02230	COG0765	amino acid transport
A388_02236	COG1464	Belongs to the NlpA lipoprotein family
A388_02238	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A388_02240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A388_02241	COG2011	ABC-type metal ion transport system permease component
A388_02242	COG0012	GTP binding
A388_02247	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A388_02255	COG0386	Belongs to the glutathione peroxidase family
A388_02257	COG0436	Aminotransferase
A388_02258	COG1301	dicarboxylic acid transport
A388_02265	COG3634	alkyl hydroperoxide reductase activity
A388_02268	COG0583	DNA-binding transcription factor activity
A388_02269	COG0798	PFAM Bile acid sodium symporter
A388_02270	COG0640	Transcriptional regulator
A388_02273	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A388_02275	COG0583	DNA-binding transcription factor activity
A388_02277	COG1953	Uracil, thiamine, allantoin
A388_02279	COG2175	clavaminate synthase activity
A388_02280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A388_02281	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A388_02282	COG4521	taurine ABC transporter
A388_02284	COG3316	Transposase and inactivated derivatives
A388_02285	COG0477	Major facilitator Superfamily
A388_02289	COG1271	oxidase subunit
A388_02290	COG1294	oxidase, subunit
A388_02292	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A388_02296	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A388_02300	COG3052	prosthetic group binding
A388_02301	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A388_02303	COG2814	Major facilitator Superfamily
A388_02306	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A388_02307	COG1346	cytolysis
A388_02309	COG0583	DNA-binding transcription factor activity
A388_02310	COG0625	glutathione transferase activity
A388_02311	COG0625	glutathione transferase activity
A388_02312	COG0583	DNA-binding transcription factor activity
A388_02315	COG1045	serine acetyltransferase
A388_02316	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A388_02317	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A388_02318	COG1280	lysine exporter protein (LysE YggA)
A388_02320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A388_02321	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A388_02322	COG1126	abc transporter atp-binding protein
A388_02323	COG0765	amino acid transport
A388_02324	COG0765	amino acid transport
A388_02327	COG0784	Response regulator, receiver
A388_02327	COG2205	protein histidine kinase activity
A388_02335	COG1028	Short-chain dehydrogenase reductase Sdr
A388_02346	COG0583	DNA-binding transcription factor activity
A388_02350	COG0318	PFAM AMP-dependent synthetase and ligase
A388_02351	COG1309	transcriptional regulator
A388_02352	COG1960	acyl-CoA dehydrogenase activity
A388_02353	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A388_02354	COG1024	Enoyl-CoA hydratase
A388_02357	COG0583	DNA-binding transcription factor activity
A388_02360	COG1960	acyl-CoA dehydrogenase activity
A388_02362	COG2814	Major facilitator Superfamily
A388_02364	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A388_02365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A388_02366	COG2814	Major facilitator Superfamily
A388_02367	COG1960	acyl-CoA dehydrogenase activity
A388_02368	COG1024	Enoyl-CoA hydratase
A388_02369	COG1028	Short-chain dehydrogenase reductase Sdr
A388_02370	COG1250	3-hydroxyacyl-CoA dehydrogenase
A388_02371	COG0183	Belongs to the thiolase family
A388_02373	COG2814	Major facilitator Superfamily
A388_02375	COG1024	Enoyl-CoA hydratase
A388_02377	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A388_02378	COG1960	acyl-CoA dehydrogenase activity
A388_02379	COG2814	Major facilitator Superfamily
A388_02380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A388_02381	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A388_02384	COG3842	ATPase activity
A388_02385	COG1840	ABC-type Fe3 transport system, periplasmic component
A388_02387	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A388_02388	COG1414	Transcriptional regulator
A388_02390	COG0583	DNA-binding transcription factor activity
A388_02391	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A388_02392	COG1012	belongs to the aldehyde dehydrogenase family
A388_02394	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A388_02395	COG1012	belongs to the aldehyde dehydrogenase family
A388_02396	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A388_02397	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A388_02398	COG2267	carboxylic ester hydrolase activity
A388_02402	COG3038	cytochrome b561
A388_02403	COG0753	catalase activity
A388_02404	COG2826	transposase and inactivated derivatives, IS30 family
A388_02405	COG2271	Major facilitator Superfamily
A388_02406	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A388_02407	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A388_02413	COG1278	Cold shock
A388_02420	COG0210	DNA helicase
A388_02421	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A388_02422	COG2050	protein possibly involved in aromatic compounds catabolism
A388_02424	COG3327	negative regulation of DNA-templated transcription, initiation
A388_02425	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A388_02426	COG0183	Belongs to the thiolase family
A388_02427	COG1250	3-hydroxyacyl-CoA dehydrogenase
A388_02428	COG1024	Enoyl-CoA hydratase
A388_02429	COG1024	Enoyl-CoA hydratase
A388_02430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A388_02431	COG2151	metal-sulfur cluster biosynthetic enzyme
A388_02432	COG3396	Phenylacetate-CoA oxygenase
A388_02433	COG3460	Phenylacetate-CoA oxygenase
A388_02434	COG3396	Phenylacetate-CoA oxygenase
A388_02435	COG2030	dehydratase
A388_02435	COG1012	belongs to the aldehyde dehydrogenase family
A388_02436	COG1760	l-serine dehydratase
A388_02437	COG0531	amino acid
A388_02438	COG1012	belongs to the aldehyde dehydrogenase family
A388_02443	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A388_02447	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A388_02450	COG0789	Transcriptional regulator
A388_02452	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A388_02455	COG2807	transmembrane transport
A388_02456	COG0590	tRNA wobble adenosine to inosine editing
A388_02458	COG0583	DNA-binding transcription factor activity
A388_02466	COG2885	chlorophyll binding
A388_02466	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A388_02475	COG2826	transposase and inactivated derivatives, IS30 family
A388_02481	COG1116	anion transmembrane transporter activity
A388_02482	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A388_02484	COG0864	Transcriptional regulator
A388_02486	COG1733	regulation of RNA biosynthetic process
A388_02487	COG2249	NAD(P)H dehydrogenase (quinone) activity
A388_02488	COG0439	Biotin carboxylase
A388_02491	COG1063	alcohol dehydrogenase
A388_02493	COG1309	transcriptional regulator
A388_02498	COG0038	chloride channel
A388_02499	COG4770	biotin carboxylase activity
A388_02503	COG1914	H( )-stimulated, divalent metal cation uptake system
A388_02504	COG0583	DNA-binding transcription factor activity
A388_02508	COG3209	COG3209 Rhs family protein
A388_02511	COG3209	COG3209 Rhs family protein
A388_02512	COG3501	Rhs element vgr protein
A388_02516	COG1250	3-hydroxyacyl-CoA dehydrogenase
A388_02520	COG2814	Major facilitator Superfamily
A388_02524	COG1560	Kdo2-lipid A biosynthetic process
A388_02527	COG5006	permease, DMT superfamily
A388_02528	COG1522	sequence-specific DNA binding
A388_02531	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A388_02539	COG1538	Outer membrane efflux protein
A388_02540	COG1137	ATPase activity
A388_02541	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A388_02543	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A388_02556	COG5434	Belongs to the glycosyl hydrolase 28 family
A388_02560	COG3566	protein conserved in bacteria
A388_02564	COG3567	Phage-associated protein, HI1409 family
A388_02565	COG5410	chromosome segregation
A388_02577	COG1733	regulation of RNA biosynthetic process
A388_02578	COG2814	Major facilitator Superfamily
A388_02586	COG1278	Cold shock
A388_02587	COG1280	lysine exporter protein (LysE YggA)
A388_02594	COG1570	exodeoxyribonuclease VII activity
A388_02605	COG0583	DNA-binding transcription factor activity
A388_02606	COG4638	Rieske (2fe-2S)
A388_02607	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A388_02608	COG0633	Ferredoxin
A388_02608	COG0543	2 iron, 2 sulfur cluster binding
A388_02609	COG1028	Short-chain dehydrogenase reductase Sdr
A388_02610	COG3135	benzoate transporter
A388_02611	COG2814	Major facilitator Superfamily
A388_02614	COG1643	Atp-dependent helicase
A388_02615	COG0450	alkyl hydroperoxide reductase
A388_02617	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A388_02619	COG3634	alkyl hydroperoxide reductase activity
A388_02623	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A388_02624	COG0625	glutathione transferase activity
A388_02626	COG2885	chlorophyll binding
A388_02636	COG1765	OsmC-like protein
A388_02638	COG2826	transposase and inactivated derivatives, IS30 family
A388_02639	COG0667	Aldo Keto reductase
A388_02642	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A388_02644	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A388_02646	COG0582	viral genome integration into host DNA
A388_02664	COG0592	DNA-directed DNA polymerase activity
A388_02708	COG1484	DNA-dependent DNA replication
A388_02723	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A388_02733	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A388_02735	COG3038	cytochrome b561
A388_02736	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A388_02737	COG2252	PERMEase
A388_02739	COG2072	flavoprotein involved in K transport
A388_02742	COG1741	Belongs to the pirin family
A388_02743	COG1309	transcriptional regulator
A388_02745	COG0300	oxidoreductase activity
A388_02746	COG2072	flavoprotein involved in K transport
A388_02747	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A388_02756	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A388_02759	COG2814	Major facilitator Superfamily
A388_02760	COG1024	Enoyl-CoA hydratase
A388_02761	COG1012	belongs to the aldehyde dehydrogenase family
A388_02763	COG1960	acyl-CoA dehydrogenase activity
A388_02768	COG2186	Transcriptional regulator
A388_02769	COG1012	belongs to the aldehyde dehydrogenase family
A388_02771	COG4948	Mandelate Racemase Muconate Lactonizing
A388_02772	COG2271	Major facilitator Superfamily
A388_02773	COG2721	sulfolactate sulfo-lyase activity
A388_02774	COG0697	spore germination
A388_02780	COG1113	amino acid transport
A388_02784	COG1012	belongs to the aldehyde dehydrogenase family
A388_02788	COG0531	amino acid
A388_02790	COG1113	amino acid transport
A388_02798	COG3209	COG3209 Rhs family protein
A388_02799	COG3501	Rhs element vgr protein
A388_02804	COG1902	pentaerythritol trinitrate reductase activity
A388_02804	COG0446	pyridine nucleotide-disulphide oxidoreductase
A388_02806	COG2203	Gaf domain
A388_02806	COG5001	Diguanylate cyclase
A388_02806	COG3706	GGDEF domain
A388_02806	COG4251	negative regulation of phosphorylation
A388_02808	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A388_02818	COG4172	Belongs to the ABC transporter superfamily
A388_02819	COG4239	(ABC) transporter, permease
A388_02820	COG4174	ABC transporter (Permease)
A388_02822	COG1388	LysM domain
A388_02822	COG0741	lytic transglycosylase activity
A388_02822	COG0741	lytic transglycosylase activity
A388_02822	COG1388	LysM domain
A388_02823	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A388_02831	COG0583	DNA-binding transcription factor activity
A388_02832	COG1279	arginine transmembrane transporter activity
A388_02836	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A388_02837	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A388_02838	COG0006	proline dipeptidase activity
A388_02845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A388_02848	COG3384	dioxygenase
A388_02850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A388_02851	COG2878	Part of a membrane complex involved in electron transport
A388_02852	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A388_02856	COG0768	penicillin binding
A388_02857	COG0742	ribosomal rna small subunit methyltransferase
A388_02860	COG0830	nickel cation binding
A388_02862	COG0804	urea catabolic process
A388_02870	COG1253	flavin adenine dinucleotide binding
A388_02871	COG2851	Citrate transporter
A388_02881	COG1773	rubredoxin
A388_02882	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A388_02884	COG0583	DNA-binding transcription factor activity
A388_02889	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A388_02890	COG4181	ATPase activity
A388_02899	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A388_02903	COG0306	phosphate transporter
A388_02905	COG3958	Transketolase
A388_02906	COG3959	Transketolase, thiamine diphosphate binding domain
A388_02907	COG2271	Major facilitator Superfamily
A388_02908	COG1028	Short-chain dehydrogenase reductase Sdr
A388_02909	COG0583	DNA-binding transcription factor activity
A388_02912	COG2223	nitrite transmembrane transporter activity
A388_02913	COG2207	Transcriptional regulator
A388_02914	COG2066	Belongs to the glutaminase family
A388_02915	COG0242	peptide deformylase activity
A388_02916	COG0477	Major facilitator Superfamily
A388_02918	COG0028	Belongs to the TPP enzyme family
A388_02921	COG1028	Short-chain dehydrogenase reductase Sdr
A388_02922	COG2267	carboxylic ester hydrolase activity
A388_02924	COG2271	Major facilitator Superfamily
A388_02925	COG0446	pyridine nucleotide-disulphide oxidoreductase
A388_02927	COG1028	Short-chain dehydrogenase reductase Sdr
A388_02931	COG1414	Transcriptional regulator
A388_02934	COG1024	Enoyl-CoA hydratase
A388_02936	COG1215	transferase activity, transferring glycosyl groups
A388_02937	COG1649	PFAM Uncharacterised BCR, COG1649
A388_02937	COG0726	polysaccharide deacetylase
A388_02939	COG4681	YaeQ
A388_02941	COG0523	cobalamin synthesis protein
A388_02943	COG1607	acyl-coa hydrolase
A388_02945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A388_02946	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A388_02947	COG1309	transcriptional regulator
A388_02952	COG2040	homocysteine
A388_02953	COG0531	amino acid
A388_02958	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A388_02959	COG0477	Major facilitator Superfamily
A388_02964	COG0084	hydrolase, TatD family'
A388_02982	COG0582	viral genome integration into host DNA
A388_02984	COG0405	Gamma-glutamyltransferase
A388_02985	COG2814	Major facilitator Superfamily
A388_02987	COG2050	protein possibly involved in aromatic compounds catabolism
A388_02990	COG1090	epimerase
A388_02994	COG0420	3'-5' exonuclease activity
A388_02999	COG0735	belongs to the Fur family
A388_03000	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A388_03004	COG0121	glutamine amidotransferase
A388_03007	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A388_03009	COG0210	DNA helicase
A388_03010	COG2885	chlorophyll binding
A388_03011	COG0204	Acyl-transferase
A388_03014	COG2894	cell division
A388_03017	COG1280	lysine exporter protein (LysE YggA)
A388_03018	COG1674	ftsk spoiiie
A388_03018	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A388_03019	COG0492	ferredoxin-NADP+ reductase activity
A388_03020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A388_03022	COG0456	acetyltransferase
A388_03034	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A388_03034	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A388_03038	COG1012	belongs to the aldehyde dehydrogenase family
A388_03042	COG0473	3-isopropylmalate dehydrogenase activity
A388_03043	COG0583	DNA-binding transcription factor activity
A388_03046	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A388_03051	COG0564	pseudouridine synthase activity
A388_03053	COG0358	DNA primase activity
A388_03056	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A388_03061	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A388_03067	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A388_03069	COG0351	phosphomethylpyrimidine kinase
A388_03069	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A388_03069	COG0352	thiamine-phosphate diphosphorylase activity
A388_03070	COG1652	LysM domain
A388_03075	COG1399	metal-binding, possibly nucleic acid-binding protein
A388_03076	COG3101	peptidyl-lysine hydroxylation
A388_03077	COG0009	L-threonylcarbamoyladenylate synthase
A388_03078	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A388_03079	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A388_03082	COG4106	trans-aconitate 2-methyltransferase activity
A388_03085	COG2226	methyltransferase
A388_03085	COG0596	Alpha beta hydrolase
A388_03085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A388_03086	COG1877	trehalose-phosphatase activity
A388_03087	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A388_03088	COG2223	nitrite transmembrane transporter activity
A388_03092	COG1196	nuclear chromosome segregation
A388_03094	COG0730	response to heat
A388_03097	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A388_03099	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A388_03109	COG0489	protein tyrosine kinase activity
A388_03111	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A388_03111	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A388_03117	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A388_03118	COG2081	HI0933 family
A388_03120	COG0668	transmembrane transport
A388_03124	COG0583	DNA-binding transcription factor activity
A388_03129	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A388_03130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A388_03136	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A388_03143	COG2205	protein histidine kinase activity
A388_03144	COG0745	RESPONSE REGULATOR receiver
A388_03147	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A388_03149	COG0384	phenazine biosynthesis protein PhzF
A388_03156	COG1309	transcriptional regulator
A388_03157	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A388_03158	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A388_03160	COG0583	DNA-binding transcription factor activity
A388_03164	COG1473	amidohydrolase
A388_03166	COG0583	DNA-binding transcription factor activity
A388_03169	COG0583	DNA-binding transcription factor activity
A388_03170	COG1053	succinate dehydrogenase
A388_03172	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A388_03173	COG2814	Major facilitator Superfamily
A388_03174	COG1960	acyl-CoA dehydrogenase activity
A388_03175	COG0583	DNA-binding transcription factor activity
A388_03176	COG1063	alcohol dehydrogenase
A388_03182	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A388_03183	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A388_03184	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A388_03187	COG3667	copper resistance
A388_03188	COG2132	Multicopper oxidase
A388_03190	COG0561	phosphatase activity
A388_03191	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A388_03193	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A388_03196	COG1214	PFAM Peptidase M22, glycoprotease
A388_03206	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A388_03208	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A388_03209	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A388_03210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A388_03219	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A388_03221	COG1846	Transcriptional regulator
A388_03222	COG1764	response to oxidative stress
A388_03230	COG0037	tRNA processing
A388_03232	COG0248	Ppx GppA phosphatase
A388_03237	COG0072	phenylalanine-tRNA ligase activity
A388_03241	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A388_03244	COG1238	metal cluster binding
A388_03245	COG0625	glutathione transferase activity
A388_03248	COG0318	PFAM AMP-dependent synthetase and ligase
A388_03249	COG3028	Belongs to the UPF0307 family
A388_03250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A388_03254	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A388_03255	COG0617	tRNA 3'-terminal CCA addition
A388_03256	COG1555	photosystem II stabilization
A388_03257	COG3956	TIGRFAM MazG family protein
A388_03259	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A388_03263	COG0784	Response regulator, receiver
A388_03263	COG2205	protein histidine kinase activity
A388_03263	COG5002	protein histidine kinase activity
A388_03264	COG1024	Enoyl-CoA hydratase
A388_03265	COG2084	Dehydrogenase
A388_03266	COG3622	Belongs to the hyi family
A388_03269	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A388_03270	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A388_03271	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A388_03272	COG0697	spore germination
A388_03274	COG2814	Major facilitator Superfamily
A388_03278	COG2132	Multicopper oxidase
A388_03281	COG2205	protein histidine kinase activity
A388_03298	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A388_03300	COG0583	DNA-binding transcription factor activity
A388_03301	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A388_03303	COG0084	hydrolase, TatD family'
A388_03306	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A388_03312	COG0440	acetolactate synthase activity
A388_03313	COG0028	Belongs to the TPP enzyme family
A388_03318	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A388_03319	COG1136	(ABC) transporter
A388_03319	COG0577	efflux transmembrane transporter activity
A388_03320	COG1538	Outer membrane efflux protein
A388_03323	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A388_03324	COG1162	GTPase activity
A388_03326	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A388_03334	COG1426	Protein conserved in bacteria
A388_03341	COG0793	Belongs to the peptidase S41A family
A388_03344	COG2267	carboxylic ester hydrolase activity
A388_03346	COG1012	belongs to the aldehyde dehydrogenase family
A388_03347	COG3265	gluconokinase activity
A388_03349	COG0800	Aldolase
A388_03351	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A388_03352	COG0857	belongs to the CobB CobQ family
A388_03352	COG0280	phosphate acetyltransferase
A388_03353	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A388_03353	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A388_03357	COG0740	serine-type endopeptidase activity
A388_03359	COG4774	siderophore transport
A388_03361	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A388_03363	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A388_03363	COG2813	Specifically methylates the guanine in position
A388_03383	COG0788	formyltetrahydrofolate deformylase activity
A388_03386	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A388_03387	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A388_03388	COG4651	solute:proton antiporter activity
A388_03388	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A388_03392	COG0724	RNA recognition motif
A388_03393	COG0210	DNA helicase
A388_03398	COG1733	regulation of RNA biosynthetic process
A388_03402	COG1280	lysine exporter protein (LysE YggA)
A388_03403	COG1560	Kdo2-lipid A biosynthetic process
A388_03405	COG1301	dicarboxylic acid transport
A388_03416	COG0473	3-isopropylmalate dehydrogenase activity
A388_03427	COG0583	DNA-binding transcription factor activity
A388_03429	COG0625	glutathione transferase activity
A388_03430	COG2378	regulation of single-species biofilm formation
A388_03431	COG0546	phosphoglycolate phosphatase activity
A388_03433	COG1530	ribonuclease E activity
A388_03437	COG0583	DNA-binding transcription factor activity
A388_03438	COG4221	oxidoreductase activity
A388_03439	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A388_03441	COG0534	Mate efflux family protein
A388_03444	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A388_03451	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A388_03452	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A388_03455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A388_03457	COG0644	oxidoreductase
A388_03457	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A388_03459	COG0425	Belongs to the sulfur carrier protein TusA family
A388_03460	COG4535	Mg2 and Co2 transporter CorC
A388_03462	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A388_03466	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A388_03467	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A388_03467	COG0475	glutathione-regulated potassium exporter activity
A388_03470	COG0484	heat shock protein binding
A388_03471	COG0789	Transcriptional regulator
A388_03472	COG0598	Magnesium transport protein CorA
A388_03476	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A388_03477	COG1074	ATP-dependent DNA helicase activity
A388_03478	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A388_03482	COG2226	methyltransferase
A388_03485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A388_03486	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A388_03489	COG2111	Na H antiporter
A388_03489	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A388_03490	COG1006	Multisubunit Na H antiporter MnhC subunit
A388_03491	COG0651	ATP synthesis coupled electron transport
A388_03493	COG2212	antiporter activity
A388_03497	COG0195	Participates in both transcription termination and antitermination
A388_03507	COG0237	dephospho-CoA kinase activity
A388_03509	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A388_03512	COG0497	DNA recombination
A388_03514	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A388_03521	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A388_03521	COG2169	Transcriptional regulator
A388_03522	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A388_03534	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A388_03537	COG0326	Molecular chaperone. Has ATPase activity
A388_03540	COG2056	Na+-H+ antiporter family
A388_03560	COG0546	phosphoglycolate phosphatase activity
A388_03561	COG1716	ATPase activity
A388_03570	COG0181	hydroxymethylbilane synthase activity
A388_03572	COG3275	phosphorelay sensor kinase activity
A388_03576	COG1538	Outer membrane efflux protein
A388_03577	COG0697	spore germination
A388_03582	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A388_03583	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A388_03584	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A388_03585	COG0772	Belongs to the SEDS family
A388_03590	COG4974	Belongs to the 'phage' integrase family
A388_03591	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A388_03593	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A388_03595	COG2197	response regulator
A388_03598	COG0793	Belongs to the peptidase S41A family
A388_03599	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A388_03600	COG0795	lipopolysaccharide-transporting ATPase activity
A388_03608	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A388_03608	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A388_03610	COG0004	ammonium transporteR
A388_03611	COG0347	Belongs to the P(II) protein family
A388_03615	COG0659	secondary active sulfate transmembrane transporter activity
A388_03620	COG0789	Transcriptional regulator
A388_03622	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A388_03632	COG3316	Transposase and inactivated derivatives
A388_03634	COG3316	Transposase and inactivated derivatives
A388_03637	COG1335	isochorismatase
A388_03639	COG1012	belongs to the aldehyde dehydrogenase family
A388_03640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A388_03642	COG1113	amino acid transport
A388_03644	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A388_03647	COG2814	Major facilitator Superfamily
A388_03649	COG0352	thiamine-phosphate diphosphorylase activity
A388_03649	COG0351	phosphomethylpyrimidine kinase
A388_03649	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A388_03653	COG1309	transcriptional regulator
A388_03654	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A388_03655	COG3706	GGDEF domain
A388_03657	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A388_03659	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A388_03660	COG3162	membrane
A388_03661	COG2205	protein histidine kinase activity
A388_03661	COG0784	Response regulator, receiver
A388_03661	COG2198	Histidine kinase
A388_03666	COG1522	sequence-specific DNA binding
A388_03667	COG1335	isochorismatase
A388_03668	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A388_03670	COG0668	transmembrane transport
A388_03671	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A388_03672	COG1519	Transferase
A388_03673	COG1902	pentaerythritol trinitrate reductase activity
A388_03678	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A388_03683	COG0426	domain, Protein
A388_03683	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A388_03684	COG4774	siderophore transport
A388_03685	COG2119	membrane
A388_03687	COG0508	dehydrogenase complex catalyzes the overall conversion of
A388_03689	COG4942	peptidase
A388_03692	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A388_03694	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A388_03698	COG0189	ligase activity
A388_03702	COG0708	Exodeoxyribonuclease III
A388_03703	COG1393	Belongs to the ArsC family
A388_03706	COG3706	GGDEF domain
A388_03713	COG2351	hydroxyisourate hydrolase activity
A388_03714	COG2233	PERMEase
A388_03716	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A388_03718	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A388_03720	COG3150	esterase
A388_03726	COG5632	N-Acetylmuramoyl-L-alanine amidase
A388_03726	COG3409	Peptidoglycan-binding domain 1 protein
A388_03726	COG1388	LysM domain
A388_03727	COG3501	Rhs element vgr protein
A388_03729	COG2918	glutathione biosynthetic process
A388_03732	COG2733	membrane
A388_03733	COG0436	Aminotransferase
A388_03734	COG0534	Mate efflux family protein
A388_03751	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A388_03752	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A388_03754	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A388_03759	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A388_03762	COG0010	Belongs to the arginase family
A388_03768	COG2188	Transcriptional regulator
A388_03770	COG0523	cobalamin synthesis protein
A388_03772	COG1113	amino acid transport
A388_03774	COG0625	glutathione transferase activity
A388_03778	COG1683	Conserved Protein
A388_03779	COG0534	Mate efflux family protein
A388_03780	COG0385	Bile acid
A388_03781	COG1335	isochorismatase
A388_03782	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A388_03786	COG2116	formate transmembrane transporter activity
A388_03787	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A388_03788	COG2133	pyrroloquinoline quinone binding
A388_03789	COG2983	Belongs to the UPF0260 family
A388_03793	COG1194	a g-specific adenine glycosylase
A388_03796	COG2818	Glycosylase
A388_03797	COG1064	alcohol dehydrogenase
A388_03798	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A388_03800	COG0583	DNA-binding transcription factor activity
A388_03801	COG0656	L-ascorbic acid biosynthetic process
A388_03802	COG2814	Major facilitator Superfamily
A388_03809	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A388_03812	COG2233	PERMEase
A388_03813	COG0583	DNA-binding transcription factor activity
A388_03818	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A388_03820	COG0733	neurotransmitter:sodium symporter activity
A388_03822	COG0625	glutathione transferase activity
A388_p00005	COG3316	Transposase and inactivated derivatives
A388_p00007	COG3316	Transposase and inactivated derivatives
A388_p00016	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A388_p00019	COG2026	Addiction module toxin, RelE StbE family
A388_p00023	COG1192	Involved in chromosome partitioning
A388_p00025	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A388_p00033	COG3316	Transposase and inactivated derivatives