locus-tag class description CBI29_00001 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CBI29_00002 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CBI29_00003 ENOG4105D74 hydrolase CBI29_00005 ENOG4108821 RND type efflux pump CBI29_00006 ENOG4108821 RND type efflux pump CBI29_00013 ENOG4108821 RND type efflux pump CBI29_00014 ENOG4105C5H ABC transporter CBI29_00015 ENOG4105DQR SNARE associated Golgi CBI29_00017 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CBI29_00019 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CBI29_00021 ENOG4105VG0 50S ribosomal protein l34 CBI29_00024 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CBI29_00027 ENOG4105PGM cation diffusion facilitator family transporter CBI29_00028 ENOG4105T95 Thiol disulfide interChange protein CBI29_00030 ENOG4108UGV hypoxanthine phosphoribosyltransferase CBI29_00032 ENOG4107QUY Guanine deaminase CBI29_00034 ENOG4106032 Glutathionylspermidine synthase CBI29_00036 ENOG4105DU1 integral membrane protein, terc CBI29_00037 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CBI29_00039 ENOG4105DFU Cell wall formation (By similarity) CBI29_00041 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CBI29_00042 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CBI29_00044 ENOG4105CVE Lytic murein transglycosylase CBI29_00055 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CBI29_00060 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase CBI29_00062 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CBI29_00063 ENOG4105DTN riboflavin biosynthesis protein ribF CBI29_00065 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CBI29_00066 ENOG4108R86 Transcriptional regulator CBI29_00067 ENOG4108VM9 ABC, transporter CBI29_00068 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CBI29_00069 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CBI29_00070 ENOG4105GVF (ABC) transporter CBI29_00071 ENOG4105GVF (ABC) transporter CBI29_00072 ENOG4107QZM n-acetylglutamate synthase CBI29_00075 ENOG4105UBK short-chain dehydrogenase reductase CBI29_00076 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CBI29_00079 ENOG41062JF Transcriptional regulator CBI29_00084 ENOG4105HSS phospholipase C CBI29_00086 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CBI29_00087 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CBI29_00088 ENOG4105CJR Integral membrane protein (MviN CBI29_00089 ENOG4108V1T peptidylprolyl cis-trans isomerase CBI29_00090 ENOG4108V1T peptidylprolyl cis-trans isomerase CBI29_00091 ENOG4105D75 Capsular exopolysaccharide family CBI29_00093 ENOG4105DAY polysaccharide export protein CBI29_00094 ENOG4107QQG Dehydrogenase CBI29_00095 ENOG4107R5Z Oxidoreductase domain protein CBI29_00096 ENOG4105J5G Transferase hexapeptide repeat containing protein CBI29_00097 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CBI29_00103 ENOG4105D3Q Sugar transferase CBI29_00104 ENOG4107WZ3 Transferase CBI29_00105 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CBI29_00108 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CBI29_00109 ENOG4105C6Y Udp-glucose 6-dehydrogenase CBI29_00111 ENOG4105CMR udp-glucose 4-epimerase CBI29_00112 ENOG4107QKV phosphomannomutase CBI29_00113 ENOG4105DAA L-lactate CBI29_00114 ENOG41073TP transcriptional regulator CBI29_00116 ENOG4105CXG d-lactate dehydrogenase CBI29_00117 ENOG4105CGF Aromatic amino acid aminotransferase CBI29_00118 ENOG4105DRR Transcriptional regulator, GntR family CBI29_00119 ENOG4105CR4 methylisocitrate lyase CBI29_00120 ENOG4105BZN citrate synthase CBI29_00121 ENOG4108I0Z Aconitate hydratase CBI29_00125 ENOG4105D5G Transposase CBI29_00128 ENOG4105D3G Pseudouridine synthase CBI29_00133 ENOG4105EW9 transcriptional regulator AsnC family CBI29_00136 ENOG4105M4H endoribonuclease L-psp CBI29_00137 ENOG4105C85 amino acid CBI29_00138 ENOG4105C85 amino acid CBI29_00140 ENOG4105C26 Dehydrogenase CBI29_00141 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CBI29_00143 ENOG4105C1G acyl-Coa dehydrogenase CBI29_00144 ENOG4105E39 Enoyl-CoA hydratase CBI29_00145 ENOG4105E39 Enoyl-CoA hydratase CBI29_00146 ENOG4105CSH Transporter CBI29_00151 ENOG4105C1G acyl-Coa dehydrogenase CBI29_00156 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CBI29_00160 ENOG4107PSF BolA-like protein CBI29_00162 ENOG4107QJE Chromosome Partitioning Protein CBI29_00165 ENOG4105DQR SNARE associated Golgi CBI29_00166 ENOG4108VBZ doxx family CBI29_00167 ENOG4106MP8 UPF0754 membrane protein CBI29_00168 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CBI29_00172 ENOG4105EUB pirin domain protein CBI29_00177 ENOG4107R1I NAD-dependent malic enzyme CBI29_00178 ENOG4105EZR dyp-type peroxidase family protein CBI29_00180 ENOG4105FAV ABC, transporter CBI29_00181 ENOG4105FDK ABC transporter CBI29_00186 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CBI29_00194 ENOG4108V06 Glutathione peroxidase CBI29_00196 ENOG4107RTG Major Facilitator superfamily CBI29_00197 ENOG4108IND Tetr family transcriptional regulator CBI29_00200 ENOG4105C79 DNA protecting protein DprA CBI29_00211 ENOG4105C6T cysteine synthase CBI29_00213 ENOG4105CS1 NAD(P)H quinone oxidoreductase CBI29_00217 ENOG4105CCT upf0313 protein CBI29_00220 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CBI29_00222 ENOG4105C0R drug resistance transporter emrb qaca subfamily CBI29_00223 ENOG4108URH decarboxylase CBI29_00224 ENOG4105EE5 Membrane protein terC CBI29_00225 ENOG4105K5B UPF0225 protein CBI29_00226 ENOG4105EN6 Membrane CBI29_00227 ENOG41079KZ Major Facilitator Superfamily CBI29_00228 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CBI29_00229 ENOG4105CEY Amp-dependent synthetase and ligase CBI29_00232 ENOG4105F0N pyrophosphate phospho-hydrolase CBI29_00233 ENOG4105EPF Outer membrane porin CBI29_00236 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CBI29_00238 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CBI29_00239 ENOG4105C0P Mg chelatase subunit ChlI CBI29_00245 ENOG4105H3G oxidoreductase CBI29_00246 ENOG4105C3M thioredoxin reductase CBI29_00247 ENOG4105CAU Arsenical resistance protein, ArsH CBI29_00248 ENOG4105D6J arsenicaL-resistance protein CBI29_00250 ENOG41082YX Transcriptional regulator, arsr family CBI29_00253 ENOG4105W1Y Transcriptional regulator CBI29_00273 ENOG4108KTG Membrane protein, drug metabolite transporter CBI29_00276 ENOG4108MBK is1 orf2 CBI29_00280 ENOG4105D13 transposase CBI29_00281 ENOG4108C33 Resolvase CBI29_00293 ENOG4108C33 Resolvase CBI29_00295 ENOG4105W1Y Transcriptional regulator CBI29_00300 ENOG4105CHH sulfate transporter CBI29_00305 ENOG4105BZU Histidine kinase CBI29_00307 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CBI29_00315 ENOG4108K5H permease YjgP YjgQ family protein CBI29_00316 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CBI29_00317 ENOG4105CN1 protease CBI29_00318 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CBI29_00319 ENOG4107TUY Histidine kinase CBI29_00321 ENOG41061WM D-Alanyl-D-Alanine CBI29_00323 ENOG4105D6E homoserine dehydrogenase CBI29_00324 ENOG4105T95 Thiol disulfide interChange protein CBI29_00325 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CBI29_00327 ENOG4105CE1 Ferrous iron transport protein b CBI29_00330 ENOG4105CNI cell division protein FtsW CBI29_00331 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) CBI29_00332 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CBI29_00333 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CBI29_00338 ENOG4108RNG Permease of the drug metabolite transporter CBI29_00339 ENOG4105DFG type I secretion outer membrane protein CBI29_00340 ENOG4108UTW Plays a role in the regulation of phosphate uptake CBI29_00343 ENOG4108HRK Histidine kinase CBI29_00344 ENOG4108NEV two component transcriptional regulator, LytTR family CBI29_00345 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CBI29_00350 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS CBI29_00353 ENOG4105GVR general secretion pathway protein D CBI29_00354 ENOG4105TV9 FHA Domain-Containing protein CBI29_00355 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CBI29_00363 ENOG4105PM1 preprotein translocase subunit SecE CBI29_00364 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CBI29_00375 ENOG4105D3Y Na H antiporter CBI29_00378 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CBI29_00381 ENOG4107ZXU DSBA oxidoreductase CBI29_00393 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CBI29_00394 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CBI29_00400 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CBI29_00402 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CBI29_00405 ENOG4105C2N RNA methyltransferase TrmH family group 3 CBI29_00407 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CBI29_00410 ENOG4107QHF type ii secretion system protein e CBI29_00412 ENOG4107EJC Preprotein translocase subunit SecG CBI29_00417 ENOG4105CHV Transcription elongation factor NusA CBI29_00420 ENOG4105KJM monovalent cation h antiporter subunit g CBI29_00421 ENOG4105W4C monovalent cation H antiporter subunit F CBI29_00422 ENOG4105SC1 monovalent cation H antiporter subunit E CBI29_00423 ENOG4107R4Z monovalent cation h antiporter subunit d CBI29_00424 ENOG4108ZE9 Monovalent cation H antiporter subunit C CBI29_00425 ENOG4105D65 subunit l CBI29_00428 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CBI29_00429 ENOG41061H0 Monooxygenase CBI29_00432 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CBI29_00434 ENOG4105CSR polyphosphate kinase 2 CBI29_00436 ENOG4105DSY exodeoxyribonuclease V, gamma CBI29_00437 ENOG4107QKA exodeoxyribonuclease V beta CBI29_00438 ENOG4107QYX exodeoxyribonuclease v alpha CBI29_00442 ENOG4107QUT magnesium and cobalt transport protein CorA CBI29_00443 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) CBI29_00444 ENOG4105DVC DnaJ domain protein CBI29_00447 ENOG4105CKD glutathione-regulated potassium-efflux system protein CBI29_00448 ENOG4105C25 Primosomal protein n' CBI29_00449 ENOG4105D7Q type ii secretion system CBI29_00450 ENOG4108VAU general secretion pathway protein G CBI29_00452 ENOG4108Z7R Chaperone CsaA CBI29_00453 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CBI29_00454 ENOG4108JU5 Magnesium and cobalt efflux protein CBI29_00455 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) CBI29_00457 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase CBI29_00459 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CBI29_00462 ENOG4105C5X domain protein CBI29_00463 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) CBI29_00465 ENOG4105BZ8 glutamate synthase CBI29_00471 ENOG4107T8P acyl-Coa dehydrogenase CBI29_00473 ENOG4107QI1 Mate efflux family protein CBI29_00475 ENOG4105CSA Coproporphyrinogen iii oxidase CBI29_00476 ENOG4105EMU Dehydrogenase CBI29_00477 ENOG4105CBN LysR family transcriptional regulator CBI29_00481 ENOG4105C03 ribonuclease CBI29_00482 ENOG4105EI2 Pseudouridine synthase CBI29_00483 ENOG4107XGZ Hydrolase CBI29_00484 ENOG4105D29 Helix-turn-helix type 11 domain protein CBI29_00487 ENOG4108W5M transcriptional regulator CBI29_00490 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase CBI29_00493 ENOG4105DUM transcriptional regulator, lysR family CBI29_00498 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CBI29_00509 ENOG4105CK2 sodium dicarboxylate symporter CBI29_00511 ENOG4105D1S lipid A biosynthesis CBI29_00512 ENOG4105N14 lysine exporter protein LysE YggA CBI29_00513 ENOG4105C5H ABC transporter CBI29_00514 ENOG41069P5 Protein slyX homolog CBI29_00516 ENOG4105KVH Transcriptional regulator CBI29_00518 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CBI29_00521 ENOG4105C4R Atp-dependent dna helicase CBI29_00522 ENOG4105VFU Rna-binding protein CBI29_00526 ENOG4105CKD glutathione-regulated potassium-efflux system protein CBI29_00527 ENOG4105W0E 50S ribosomal protein L33 CBI29_00528 ENOG4105KDC 50s ribosomal protein l28 CBI29_00529 ENOG4107RGH Aldehyde dehydrogenase CBI29_00531 ENOG4105CIY formyltetrahydrofolate deformylase CBI29_00551 ENOG4105DWV Homoserine O-trans-acetylase CBI29_00553 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CBI29_00555 ENOG4108ESX Receptor CBI29_00557 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CBI29_00561 ENOG4107GFK fumarate CBI29_00562 ENOG4108DNC Involved in acetate metabolism (By similarity) CBI29_00563 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CBI29_00564 ENOG4105C01 Dihydroxy-acid dehydratase CBI29_00565 ENOG4108UHU Aldolase CBI29_00566 ENOG4105C6Z Gluconate CBI29_00567 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CBI29_00568 ENOG4105C26 Dehydrogenase CBI29_00570 ENOG4106HB6 Alpha beta hydrolase CBI29_00573 ENOG4105CN1 protease CBI29_00576 ENOG4105WVQ Fe-S assembly protein IscX CBI29_00580 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) CBI29_00584 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CBI29_00588 ENOG4105VW4 glutaredoxin 3 CBI29_00590 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CBI29_00591 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CBI29_00593 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CBI29_00594 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CBI29_00595 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CBI29_00596 ENOG4105DJY efflux transporter, rnd family, mfp subunit CBI29_00601 ENOG4105C7K acetolactate synthase CBI29_00602 ENOG4108ZP8 Acetolactate synthase small subunit CBI29_00604 ENOG4105BZU Histidine kinase CBI29_00608 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CBI29_00611 ENOG4105F8V Hydrolase, tatD family CBI29_00612 ENOG4107QM5 aconitate hydratase CBI29_00613 ENOG4105CUZ uba thif-type nad fad binding protein CBI29_00614 ENOG4107RSM transcriptional regulator CBI29_00616 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CBI29_00633 ENOG4105GR3 Histidine kinase CBI29_00636 ENOG4105E3B Multicopper oxidase CBI29_00642 ENOG4106UX7 integral membrane protein CBI29_00643 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CBI29_00644 ENOG4105W8H transhydrogenase (subunit alpha CBI29_00645 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CBI29_00648 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CBI29_00649 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CBI29_00650 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase CBI29_00651 ENOG4105BZU Histidine kinase CBI29_00652 ENOG4105C6T cysteine synthase CBI29_00655 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CBI29_00657 ENOG4105DXN mazG family CBI29_00658 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CBI29_00659 ENOG4105DJ0 Poly(A) Polymerase CBI29_00660 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CBI29_00664 ENOG41080Z8 PHOSPHOCARRIER protein CBI29_00665 ENOG4105N42 UPF0307 protein CBI29_00666 ENOG4105CEY Amp-dependent synthetase and ligase CBI29_00669 ENOG4105CYM Glutathione S-transferase CBI29_00670 ENOG4105W39 Membrane CBI29_00673 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CBI29_00677 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CBI29_00680 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CBI29_00682 ENOG4105C9X ppx gppa phosphatase CBI29_00684 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CBI29_00685 ENOG4105II7 pyrroline-5-carboxylate reductase CBI29_00686 ENOG4108VIA integral membrane protein CBI29_00687 ENOG4105C2M dna polymerase I CBI29_00691 ENOG4107QHF type ii secretion system protein e CBI29_00692 ENOG4108ZHJ Organic hydroperoxide resistance protein CBI29_00693 ENOG4105K56 Transcriptional regulator CBI29_00704 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CBI29_00705 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CBI29_00706 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CBI29_00708 ENOG4105CRQ synthase (Component I) CBI29_00717 ENOG4108Z0R Transferase CBI29_00718 ENOG41072GX Peptidase M22 Glycoprotease CBI29_00721 ENOG4105C4W S-formylglutathione hydrolase CBI29_00723 ENOG4105DJV ribulose-phosphate 3-epimerase CBI29_00724 ENOG4108HCJ Hydrolase CBI29_00726 ENOG4105E3B Multicopper oxidase CBI29_00727 ENOG4105VR0 copper resistance CBI29_00730 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CBI29_00731 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CBI29_00732 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CBI29_00739 ENOG4105ETT transcriptional Regulator, LysR family CBI29_00740 ENOG4105C1G acyl-Coa dehydrogenase CBI29_00741 ENOG4107RGD Major Facilitator superfamily CBI29_00742 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CBI29_00744 ENOG4107EFR Flavocytochrome c CBI29_00745 ENOG4106P55 Transcriptional regulator CBI29_00748 ENOG4106P55 Transcriptional regulator CBI29_00750 ENOG4105CH2 amidohydrolase CBI29_00754 ENOG4105ETT transcriptional Regulator, LysR family CBI29_00756 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CBI29_00757 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) CBI29_00758 ENOG41082JN Transcriptional regulator CBI29_00764 ENOG4105JAB phenazine biosynthesis protein, phzf family CBI29_00766 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CBI29_00768 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CBI29_00769 ENOG4107EXC regulatoR CBI29_00770 ENOG4105E0F Histidine kinase CBI29_00772 ENOG4105BZU Histidine kinase CBI29_00776 ENOG4105GKE subunit e CBI29_00777 ENOG4107QIZ NADH dehydrogenase CBI29_00778 ENOG4108IEH NADH dehydrogenase subunit g CBI29_00781 ENOG4107UFS subunit j CBI29_00783 ENOG4105D65 subunit l CBI29_00784 ENOG4105C8S subunit m CBI29_00789 ENOG4105DUM transcriptional regulator, lysR family CBI29_00790 ENOG4105DP0 ferredoxin-NADP reductase CBI29_00795 ENOG4105CBX hi0933 family CBI29_00796 ENOG4105K6H D-cysteine desulfhydrase CBI29_00802 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CBI29_00804 ENOG4105D1F ATP-binding protein CBI29_00814 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) CBI29_00816 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CBI29_00819 ENOG4105HF0 Membrane CBI29_00821 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CBI29_00825 ENOG4106UW1 Major Facilitator superfamily CBI29_00826 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase CBI29_00827 ENOG4108K4C ec 3.1.3.12 CBI29_00828 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CBI29_00830 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CBI29_00831 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CBI29_00833 ENOG4105FE9 pseudouridine synthase CBI29_00834 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CBI29_00835 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CBI29_00836 ENOG4107RTD sua5 ycio yrdc ywlc family protein CBI29_00837 ENOG4108BPE -transporting atpase CBI29_00838 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CBI29_00840 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CBI29_00841 ENOG4105CHR reductase CBI29_00843 ENOG4109066 lysm domain bon superfamily protein CBI29_00844 ENOG4105DWF phosphomethylpyrimidine kinase CBI29_00846 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CBI29_00852 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CBI29_00857 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) CBI29_00860 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CBI29_00861 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CBI29_00862 ENOG4105C34 Pseudouridine synthase CBI29_00863 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CBI29_00867 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CBI29_00870 ENOG4105EJC lysr family transcriptional regulator CBI29_00871 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CBI29_00872 ENOG4105C94 Transporter CBI29_00874 ENOG4105DVW rieske (2Fe-2S) CBI29_00875 ENOG4105C26 Dehydrogenase CBI29_00876 ENOG4105E3J oxidoreductase CBI29_00879 ENOG4105C4K Nad synthetase CBI29_00881 ENOG4105EUB pirin domain protein CBI29_00882 ENOG4108YXA Membrane CBI29_00891 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CBI29_00893 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) CBI29_00894 ENOG4105C3M thioredoxin reductase CBI29_00895 ENOG4105CNU cell division protein FtsK CBI29_00899 ENOG4107QMS site-determining protein CBI29_00902 ENOG4106HNH Acyl-transferase CBI29_00903 ENOG4108ZG0 Ompa motb domain protein CBI29_00904 ENOG4105C4R Atp-dependent dna helicase CBI29_00906 ENOG4107QKV phosphomannomutase CBI29_00909 ENOG4105E7A Glutamine amidotransferase CBI29_00914 ENOG41090R7 Ferric uptake CBI29_00915 ENOG4105CZX twitching motility protein CBI29_00916 ENOG4105CZX twitching motility protein CBI29_00917 ENOG4105DFA alanine racemase domain protein CBI29_00918 ENOG4105EYH Exonuclease CBI29_00919 ENOG4107RH8 nuclease SbcCD subunit D CBI29_00923 ENOG4105ECP epimerase CBI29_00924 ENOG4105MWK D-amino acid dehydrogenase, small subunit CBI29_00925 ENOG4105D52 delta-aminolevulinic acid dehydratase CBI29_00926 ENOG4108VUY thioesterase Superfamily protein CBI29_00927 ENOG4105CW7 secretion protein, HlyD family CBI29_00928 ENOG4105C0R drug resistance transporter emrb qaca subfamily CBI29_00929 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CBI29_00931 ENOG4105DFP Integrase CBI29_00949 ENOG4105F8V Hydrolase, tatD family CBI29_00954 ENOG4105C54 Major Facilitator superfamily CBI29_00955 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CBI29_00957 ENOG4108SF5 RNA Polymerase CBI29_00963 ENOG4108YNN Heme oxygenase CBI29_00968 ENOG4105D5Q Arginine ornithine antiporter CBI29_00969 ENOG4107QK5 Homocysteine s-methyltransferase CBI29_00974 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) CBI29_00975 ENOG4105C94 Transporter CBI29_00976 ENOG4105C94 Transporter CBI29_00980 ENOG4105CKI cobalamin synthesis protein CBI29_00982 ENOG4108VWS Yaeq family CBI29_00984 ENOG4107BJW polysaccharide deacetylase CBI29_00985 ENOG4105CND Glycosyl transferase, family 2 CBI29_00987 ENOG4106YT9 Enoyl-CoA hydratase CBI29_00990 ENOG41069M3 Transcriptional regulator CBI29_00994 ENOG4105CHR reductase CBI29_00996 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase CBI29_00997 ENOG4105DJB Major Facilitator Superfamily CBI29_00999 ENOG4108MXF Alpha Beta Hydrolase CBI29_01000 ENOG4105CHR reductase CBI29_01003 ENOG4105C7K acetolactate synthase CBI29_01005 ENOG4105CSH Transporter CBI29_01007 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CBI29_01008 ENOG4105CSV Glutaminase CBI29_01009 ENOG4108R6W Transcriptional regulator, ARAC family CBI29_01010 ENOG4105EU0 Major facilitator Superfamily CBI29_01011 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CBI29_01013 ENOG4108PZW LysR family Transcriptional regulator CBI29_01015 ENOG4105CSP Major Facilitator Superfamily CBI29_01018 ENOG4105C3R Methionine synthase CBI29_01019 ENOG4105CJ3 phosphate transporter CBI29_01023 ENOG4105E6M Sulphatase-modifying factor protein CBI29_01024 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) CBI29_01027 ENOG4107RNH Outer membrane receptor FepA CBI29_01033 ENOG4108UJV acyl-CoA thioesterase i CBI29_01034 ENOG4108I0Y (ABC) transporter CBI29_01035 ENOG4105CV6 ABC transporter, permease CBI29_01036 ENOG4107U91 Rhomboid family CBI29_01040 ENOG4105C5Q Transcriptional regulator CBI29_01042 ENOG4107QZF nitrite reductase NADPH large subunit CBI29_01043 ENOG4105VCQ rubredoxin CBI29_01047 ENOG4108MRJ CBI29_01050 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) CBI29_01053 ENOG4105D4T Citrate transporter CBI29_01054 ENOG4105C37 (CBS) domain CBI29_01056 ENOG4107RET Isocitrate lyase CBI29_01062 ENOG4105CQM Urea amidohydrolase subunit alpha CBI29_01064 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CBI29_01067 ENOG4106H78 methyltransferase CBI29_01068 ENOG4105CJN penicillin-binding protein CBI29_01072 ENOG4105CSM endonuclease III CBI29_01073 ENOG4108R3D Electron transport complex CBI29_01074 ENOG4105D82 Glutamate dehydrogenase CBI29_01076 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CBI29_01079 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CBI29_01086 ENOG4107RAQ aminopeptidase CBI29_01087 ENOG4105D0A hydroxylase CBI29_01088 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CBI29_01092 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CBI29_01093 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CBI29_01095 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CBI29_01097 ENOG4105W4M Transport-associated protein CBI29_01099 ENOG4105E09 nadh pyrophosphatase CBI29_01101 ENOG4107RZZ dna polymerase iii epsilon subunit CBI29_01102 ENOG4105E9H Lytic Murein transglycosylase CBI29_01102 ENOG4105E9H Lytic Murein transglycosylase CBI29_01104 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component CBI29_01105 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component CBI29_01106 ENOG4108JQ5 ABC transporter CBI29_01116 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) CBI29_01120 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CBI29_01122 ENOG4105D01 (LipO)protein CBI29_01126 ENOG4105CNA YD repeat protein CBI29_01134 ENOG4105C85 amino acid CBI29_01136 ENOG4105CUB amino acid CBI29_01140 ENOG4105C26 Dehydrogenase CBI29_01144 ENOG4105C85 amino acid CBI29_01148 ENOG4107RGH Aldehyde dehydrogenase CBI29_01149 ENOG4108ZX5 transcriptional regulator CBI29_01150 ENOG4105DJP Membrane CBI29_01151 ENOG4105CTX dehydratase CBI29_01152 ENOG4105DJB Major Facilitator Superfamily CBI29_01153 ENOG4105EQX glucarate dehydratase CBI29_01155 ENOG4105CZJ Aldehyde dehydrogenase CBI29_01156 ENOG4105JXH GntR family transcriptional regulator CBI29_01159 ENOG4105NI3 Protein of unknown function (DUF3237) CBI29_01160 ENOG4105EPF Outer membrane porin CBI29_01161 ENOG4105C1G acyl-Coa dehydrogenase CBI29_01164 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase CBI29_01165 ENOG4108SC4 )-transporter CBI29_01168 ENOG4105E3J oxidoreductase CBI29_01170 ENOG4105D2S major facilitator superfamily CBI29_01171 ENOG4105EPF Outer membrane porin CBI29_01175 ENOG4107RN6 Monooxygenase CBI29_01177 ENOG4105JQZ Methyltransferase CBI29_01178 ENOG4105F95 Monooxygenase CBI29_01185 ENOG4105F95 Monooxygenase CBI29_01187 ENOG4105C7N Xanthine uracil vitamin C permease CBI29_01188 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CBI29_01189 ENOG4105CPW cytochrome b561 CBI29_01191 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CBI29_01193 ENOG4105CFH Aspartokinase CBI29_01201 ENOG41083X2 DNA polymerase III, epsilon subunit CBI29_01259 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CBI29_01274 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CBI29_01279 ENOG4105DFP Integrase CBI29_01281 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CBI29_01283 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CBI29_01286 ENOG4105CPC Aldo Keto reductase CBI29_01287 ENOG4107RYR Transcriptional regulator, Crp Fnr family CBI29_01288 ENOG4108UKZ OsmC family CBI29_01291 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CBI29_01297 ENOG4105CD3 dihydroorotase CBI29_01298 ENOG4108ZG0 Ompa motb domain protein CBI29_01300 ENOG4108TGY Glutathione S-transferase CBI29_01301 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CBI29_01303 ENOG4108K3A Glutathione S-transferase CBI29_01305 ENOG4108JU3 Alkyl hydroperoxide reductase CBI29_01307 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CBI29_01309 ENOG4105D3R alkyl hydroperoxide reductase CBI29_01310 ENOG4105CQ7 ATP-dependent helicase CBI29_01313 ENOG4105D2S major facilitator superfamily CBI29_01314 ENOG4105DKK Benzoate CBI29_01315 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase CBI29_01316 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein CBI29_01317 ENOG4108UKV benzoate 1,2-dioxygenase CBI29_01318 ENOG4105FUY alpha subunit CBI29_01319 ENOG4108KB2 LysR family Transcriptional regulator CBI29_01330 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CBI29_01337 ENOG410829K Lysine exporter protein (Lyse ygga) CBI29_01338 ENOG4105VEQ Cold shock protein CBI29_01340 ENOG4105II7 pyrroline-5-carboxylate reductase CBI29_01346 ENOG4107YPT transcriptional regulator CBI29_01359 ENOG4107ZQ5 Phage-associated protein, HI1409 family CBI29_01363 ENOG41090AG Bacteriophage protein CBI29_01379 ENOG4105C2X Arabinose 5-phosphate isomerase CBI29_01380 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CBI29_01382 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CBI29_01383 ENOG4108IUZ ABC transporter CBI29_01384 ENOG4105DFG type I secretion outer membrane protein CBI29_01392 ENOG4108Z4U Ferredoxin CBI29_01396 ENOG4107AQZ Membrane CBI29_01398 ENOG4105BZU Histidine kinase CBI29_01399 ENOG4105D1S lipid A biosynthesis CBI29_01401 ENOG4105D2S major facilitator superfamily CBI29_01406 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) CBI29_01411 ENOG4105CNA YD repeat protein CBI29_01414 ENOG4105CNA YD repeat protein CBI29_01418 ENOG4108WAV Transcriptional regulator CBI29_01419 ENOG4105C5A transporter CBI29_01423 ENOG4108JIK carboxylase CBI29_01424 ENOG4107R4J Chloride channel CBI29_01429 ENOG4105R8C Transcriptional regulator CBI29_01431 ENOG4105E2A Dehydrogenase CBI29_01434 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CBI29_01435 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF CBI29_01438 ENOG4105MRR Transcriptional regulator (By similarity) CBI29_01440 ENOG4108HW3 (ABC) transporter CBI29_01454 ENOG4105UYK outer membrane protein a CBI29_01456 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CBI29_01462 ENOG4105EMY transcriptional regulator CBI29_01464 ENOG4107Y2X deaminase CBI29_01465 ENOG4105DJ2 Major Facilitator Superfamily CBI29_01468 ENOG4105WPN DNA integration recombination invertion protein CBI29_01470 ENOG4108Z4X TRANSCRIPTIONal CBI29_01473 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CBI29_01477 ENOG4105MWK D-amino acid dehydrogenase, small subunit CBI29_01482 ENOG4105CZJ Aldehyde dehydrogenase CBI29_01483 ENOG4107QTZ amino acid CBI29_01484 ENOG4105EJQ L-serine dehydratase CBI29_01485 ENOG4105DXM phenylacetic acid degradation protein CBI29_01486 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit CBI29_01487 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit CBI29_01488 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit CBI29_01489 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit CBI29_01490 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CBI29_01491 ENOG4105E39 Enoyl-CoA hydratase CBI29_01492 ENOG4108UKI Enoyl-CoA hydratase CBI29_01493 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CBI29_01494 ENOG4105CHU acetyl-coa acetyltransferase CBI29_01495 ENOG4105DZS Phenylacetate-CoA ligase CBI29_01496 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein CBI29_01497 ENOG4108Z0R Transferase CBI29_01498 ENOG4107YAU phenylacetic acid degradation protein CBI29_01499 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CBI29_01500 ENOG4105C4R Atp-dependent dna helicase CBI29_01506 ENOG4105VEQ Cold shock protein CBI29_01512 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CBI29_01513 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CBI29_01514 ENOG4105CSP Major Facilitator Superfamily CBI29_01515 ENOG4107VGR Catalase CBI29_01516 ENOG4105CPW cytochrome b561 CBI29_01520 ENOG4108MXF Alpha Beta Hydrolase CBI29_01521 ENOG4105MXW flavin reductase domain protein, FMN-binding CBI29_01522 ENOG4108M8W Monooxygenase CBI29_01523 ENOG4105C26 Dehydrogenase CBI29_01524 ENOG4105ETS cytosine purines uracil thiamine allantoin CBI29_01526 ENOG4105C26 Dehydrogenase CBI29_01527 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CBI29_01528 ENOG4105HEI LysR family (Transcriptional regulator CBI29_01530 ENOG4107HP6 Transcriptional regulator CBI29_01531 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase CBI29_01533 ENOG4105C4Y ABC transporter CBI29_01534 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CBI29_01535 ENOG4107RCV ABC transporter, permease CBI29_01537 ENOG4107STF Involved in phosphonate degradation (By similarity) CBI29_01538 ENOG4108KAZ Involved in phosphonate degradation (By similarity) CBI29_01539 ENOG4107RGD Major Facilitator superfamily CBI29_01540 ENOG4105C1G acyl-Coa dehydrogenase CBI29_01541 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CBI29_01543 ENOG4108UKI Enoyl-CoA hydratase CBI29_01544 ENOG4105EA8 2-Nitropropane dioxygenase CBI29_01545 ENOG4105EQ0 Major Facilitator superfamily CBI29_01547 ENOG4105CHU acetyl-coa acetyltransferase CBI29_01548 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CBI29_01549 ENOG4105CHR reductase CBI29_01550 ENOG4105E39 Enoyl-CoA hydratase CBI29_01551 ENOG4105C1G acyl-Coa dehydrogenase CBI29_01552 ENOG4107RGD Major Facilitator superfamily CBI29_01553 ENOG4107QP7 CoA-transferase subunit A CBI29_01554 ENOG4107QNJ CoA-transferase subunit B CBI29_01556 ENOG4105EQ0 Major Facilitator superfamily CBI29_01558 ENOG4105CSU acyl-Coa dehydrogenase CBI29_01561 ENOG4105CC0 LysR family Transcriptional regulator CBI29_01564 ENOG4105E39 Enoyl-CoA hydratase CBI29_01565 ENOG4107QX3 carboxylase CBI29_01566 ENOG4105C1G acyl-Coa dehydrogenase CBI29_01567 ENOG4105R8C Transcriptional regulator CBI29_01568 ENOG4105CEY Amp-dependent synthetase and ligase CBI29_01572 ENOG4105HEI LysR family (Transcriptional regulator CBI29_01583 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CBI29_01589 ENOG4105EW9 transcriptional regulator AsnC family CBI29_01591 ENOG4105BZU Histidine kinase CBI29_01592 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CBI29_01594 ENOG4105EAD ABC transporter CBI29_01595 ENOG4108HW4 amino acid AbC transporter CBI29_01596 ENOG4105CDA abc transporter atp-binding protein CBI29_01597 ENOG4107RP9 extracellular solute-binding protein, family 3 CBI29_01598 ENOG4105CT1 (ABC) transporter CBI29_01599 ENOG4105EXG Transcriptional regulator CBI29_01601 ENOG4105C9B Cysteine desulfurase CBI29_01602 ENOG4105ESN nucleotide-binding protein CBI29_01603 ENOG4105D7W serine acetyltransferase CBI29_01605 ENOG4105CHR reductase CBI29_01606 ENOG4105CBN LysR family transcriptional regulator CBI29_01607 ENOG4105CYM Glutathione S-transferase CBI29_01608 ENOG4108SHQ Glutathione S-transferase CBI29_01609 ENOG4105CMU LysR family (Transcriptional regulator CBI29_01610 ENOG4105VAW lrga family CBI29_01611 ENOG41067MG lrgb family CBI29_01612 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CBI29_01615 ENOG4105DXI Major Facilitator superfamily CBI29_01617 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CBI29_01618 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) CBI29_01622 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CBI29_01625 ENOG4108K70 Transcriptional regulator CBI29_01626 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CBI29_01628 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CBI29_01629 ENOG4105C4M (Ubiquinol oxidase) subunit I CBI29_01633 ENOG4105C54 Major Facilitator superfamily CBI29_01635 ENOG4106FTQ Taurine ABC transporter, periplasmic CBI29_01636 ENOG4108IY8 ABC, transporter CBI29_01637 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CBI29_01638 ENOG4105E2B Taurine dioxygenase CBI29_01640 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CBI29_01642 ENOG4105CBN LysR family transcriptional regulator CBI29_01644 ENOG4105CPN adenine deaminase CBI29_01647 ENOG41082YX Transcriptional regulator, arsr family CBI29_01648 ENOG4105D6J arsenicaL-resistance protein CBI29_01649 ENOG4108KB2 LysR family Transcriptional regulator CBI29_01652 ENOG4108JU3 Alkyl hydroperoxide reductase CBI29_01657 ENOG4105C0B DNA polymerase III (alpha subunit) CBI29_01659 ENOG4105CK2 sodium dicarboxylate symporter CBI29_01660 ENOG4105CHM Aminotransferase CBI29_01662 ENOG4108V06 Glutathione peroxidase CBI29_01663 ENOG4105E7U AraC family transcriptional regulator CBI29_01669 ENOG4105ZED uncharacterized protein ygaH CBI29_01670 ENOG4108UMN azlc family CBI29_01675 ENOG4105C3G gtp-binding protein CBI29_01676 ENOG4108UMI ABC transporter, permease CBI29_01677 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CBI29_01678 ENOG4105D01 (LipO)protein CBI29_01679 ENOG4105D01 (LipO)protein CBI29_01682 ENOG4107T8P acyl-Coa dehydrogenase CBI29_01685 ENOG4105EAD ABC transporter CBI29_01686 ENOG4105DRP amino acid AbC transporter CBI29_01687 ENOG4105CDA abc transporter atp-binding protein CBI29_01689 ENOG4105EW9 transcriptional regulator AsnC family CBI29_01692 ENOG41067SE Tetr family transcriptional regulator CBI29_01697 ENOG4105CC0 LysR family Transcriptional regulator CBI29_01699 ENOG4105ETS cytosine purines uracil thiamine allantoin CBI29_01701 ENOG4108IPJ Membrane CBI29_01706 ENOG4105GQR Chaperone CBI29_01707 ENOG4105X0I Fimbrial CBI29_01711 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CBI29_01712 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CBI29_01716 ENOG4108HWY Beta-lactamase CBI29_01721 ENOG4105CV1 Transketolase (EC 2.2.1.1) CBI29_01723 ENOG4108YYC ycei family CBI29_01725 ENOG4108T58 Mg2 transport protein CorA CBI29_01728 ENOG4105YGK Pfam:UPF0157 CBI29_01729 ENOG4105C26 Dehydrogenase CBI29_01730 ENOG4105EW9 transcriptional regulator AsnC family CBI29_01731 ENOG4105CK7 Sodium proline symporter CBI29_01732 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CBI29_01734 ENOG4108ZX5 transcriptional regulator CBI29_01736 ENOG4105BZ1 (ABC) transporter CBI29_01737 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme CBI29_01738 ENOG4105XPP Protein of unknown function (DUF1275) CBI29_01740 ENOG41080HT Transcriptional regulator, arsr family CBI29_01742 ENOG4105EZE Cupin 4 family protein CBI29_01743 ENOG4108UHJ MAF-like protein CBI29_01747 ENOG4105D2N Aldolase CBI29_01748 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CBI29_01749 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CBI29_01750 ENOG4105EHM Aminoglycoside phosphotransferase CBI29_01751 ENOG4108S0S Nucleotidyl transferase CBI29_01753 ENOG4107QJE Chromosome Partitioning Protein CBI29_01754 ENOG4105FA0 parb-like partition protein CBI29_01757 ENOG4105BZ1 (ABC) transporter CBI29_01758 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CBI29_01760 ENOG4107QRG dna polymerase iii CBI29_01762 ENOG4105F8V Hydrolase, tatD family CBI29_01767 ENOG4108RTD type II secretion system protein K CBI29_01771 ENOG4108Z6B deaminase CBI29_01774 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CBI29_01775 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CBI29_01779 ENOG4107RN6 Monooxygenase CBI29_01781 ENOG4105D6Z AFG1 family ATPase CBI29_01782 ENOG4107QP3 malate synthase g CBI29_01783 ENOG4105SG9 biopolymer transport protein, ExbD CBI29_01786 ENOG4108DNJ Pfam:TonB CBI29_01791 ENOG4105DGW oligopeptidase A CBI29_01793 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CBI29_01797 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CBI29_01800 ENOG4105K4T epimerase CBI29_01801 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) CBI29_01805 ENOG4108JA2 transcriptioN-repair coupling factor CBI29_01807 ENOG4105F8J Adenylate Guanylate cyclase CBI29_01808 ENOG4108ZIT Ferredoxin, 2FE-2S CBI29_01811 ENOG4108Z4V iron-sulfur cluster assembly CBI29_01812 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CBI29_01814 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CBI29_01817 ENOG4105K70 DNA-binding protein CBI29_01818 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CBI29_01819 ENOG4105E7U AraC family transcriptional regulator CBI29_01820 ENOG4105EEF Alkane 1-monooxygenase CBI29_01821 ENOG4105C1G acyl-Coa dehydrogenase CBI29_01822 ENOG4105C1G acyl-Coa dehydrogenase CBI29_01825 ENOG4108Z66 YbaK ebsC protein CBI29_01828 ENOG4105C0R drug resistance transporter emrb qaca subfamily CBI29_01829 ENOG4105DUU IucA IucC family protein CBI29_01830 ENOG4105DJU Siderophore biosynthesis protein CBI29_01832 ENOG4105JSC dimethylmenaquinone methyltransferase CBI29_01838 ENOG4107VXZ Hydrolase CBI29_01840 ENOG4108YZT Adenosylcobinamide kinase CBI29_01841 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CBI29_01842 ENOG4107TB6 phosphoglycerate mutase CBI29_01845 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CBI29_01846 ENOG4107TSN permease CBI29_01850 ENOG4105CNM Receptor CBI29_01851 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CBI29_01856 ENOG4105K59 histidine triad (HIT) protein CBI29_01862 ENOG4105F2W methyltransferase CBI29_01864 ENOG4105C28 cystathionine CBI29_01867 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CBI29_01876 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CBI29_01877 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CBI29_01879 ENOG4105BZU Histidine kinase CBI29_01882 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CBI29_01883 ENOG4107R0V Pyruvate dehydrogenase CBI29_01884 ENOG4105CPP Dehydrogenase, E1 component CBI29_01887 ENOG4105CHR reductase CBI29_01889 ENOG4105FFC UPF0187 protein CBI29_01891 ENOG4107S76 domain protein CBI29_01893 ENOG4108VCT Sulfite exporter TauE/SafE CBI29_01896 ENOG4105UEI Transcriptional Regulator AraC Family CBI29_01897 ENOG4105KVH Transcriptional regulator CBI29_01898 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CBI29_01900 ENOG4105FDP GntR family transcriptional regulator CBI29_01903 ENOG4106FTQ Taurine ABC transporter, periplasmic CBI29_01904 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CBI29_01908 ENOG4105CSH Transporter CBI29_01910 ENOG4108IJ0 Aspartate ammonia-lyase CBI29_01913 ENOG4107YNJ LysR family Transcriptional regulator CBI29_01915 ENOG4105CHU acetyl-coa acetyltransferase CBI29_01916 ENOG4105CRW Short chain fatty acid transporter CBI29_01919 ENOG4108M0I Transcriptional regulator CBI29_01921 ENOG4105CY2 Citrate transporter CBI29_01922 ENOG4105DTD Dehydrogenase CBI29_01923 ENOG4105CF7 AraC family transcriptional regulator CBI29_01924 ENOG4105D2S major facilitator superfamily CBI29_01926 ENOG4105CHR reductase CBI29_01931 ENOG4105F57 Anthranilate dioxygenase reductase CBI29_01932 ENOG4108YS2 small subunit CBI29_01933 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit CBI29_01934 ENOG4105F4R Transcriptional regulator mode CBI29_01935 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CBI29_01936 ENOG4105E0C molybdate abc transporter CBI29_01937 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CBI29_01940 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CBI29_01941 ENOG4105WQI isochorismatase CBI29_01943 ENOG4107T31 5'-nucleotidase CBI29_01949 ENOG4108IGT Dipeptidase CBI29_01953 ENOG4107RZC phospholipase d CBI29_01993 ENOG4105CJP fad dependent oxidoreductase CBI29_01995 ENOG4105CT3 Monooxygenase CBI29_01997 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CBI29_01998 ENOG4105BZS acriflavin resistance protein CBI29_01999 ENOG4105C1P efflux transporter, rnd family, mfp subunit CBI29_02000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CBI29_02001 ENOG4105E0F Histidine kinase CBI29_02003 ENOG4108R6W Transcriptional regulator, ARAC family CBI29_02006 ENOG4108BAS reductase CBI29_02007 ENOG4105EQ2 LysR family Transcriptional regulator CBI29_02008 ENOG4105ENX hydrolase CBI29_02014 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CBI29_02017 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CBI29_02030 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CBI29_02032 ENOG4105CF7 AraC family transcriptional regulator CBI29_02033 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CBI29_02035 ENOG4105EXW epimerase dehydratase CBI29_02036 ENOG4105DDW LysR family Transcriptional regulator CBI29_02038 ENOG4105C01 Dihydroxy-acid dehydratase CBI29_02039 ENOG4105CZJ Aldehyde dehydrogenase CBI29_02042 ENOG4105CW7 secretion protein, HlyD family CBI29_02045 ENOG4106KR7 LysR family Transcriptional regulator CBI29_02048 ENOG4105FDP GntR family transcriptional regulator CBI29_02062 ENOG4105CH2 amidohydrolase CBI29_02064 ENOG4105CKD glutathione-regulated potassium-efflux system protein CBI29_02065 ENOG4105D8V Glucose sorbosone dehydrogenase CBI29_02066 ENOG4105EJC lysr family transcriptional regulator CBI29_02067 ENOG4105CHJ isochorismatase hydrolase CBI29_02072 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CBI29_02074 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) CBI29_02075 ENOG4105EMU Dehydrogenase CBI29_02076 ENOG4108ZX5 transcriptional regulator CBI29_02077 ENOG4107Z3H Transcriptional regulator, TetR family CBI29_02085 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CBI29_02088 ENOG4105CZJ Aldehyde dehydrogenase CBI29_02092 ENOG4107EJG GntR family transcriptional regulator CBI29_02094 ENOG4108KB2 LysR family Transcriptional regulator CBI29_02095 ENOG4105DTQ mandelate racemase muconate lactonizing CBI29_02096 ENOG4105NN7 muconolactone delta-isomerase CBI29_02098 ENOG4107QP7 CoA-transferase subunit A CBI29_02099 ENOG4107QNJ CoA-transferase subunit B CBI29_02100 ENOG4105CHU acetyl-coa acetyltransferase CBI29_02101 ENOG4105F2Z 3-oxoadipate enol-lactonase CBI29_02103 ENOG4105C26 Dehydrogenase CBI29_02105 ENOG4105F11 amine oxidase CBI29_02109 ENOG4105CHR reductase CBI29_02111 ENOG4105FUY alpha subunit CBI29_02115 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CBI29_02117 ENOG4105DNH Major Facilitator CBI29_02122 ENOG4105C1G acyl-Coa dehydrogenase CBI29_02123 ENOG4108PTX LysR family Transcriptional regulator CBI29_02124 ENOG4107HP6 Transcriptional regulator CBI29_02127 ENOG4105MD1 YeeE YedE family protein CBI29_02129 ENOG4105DZG Dehydrogenase CBI29_02130 ENOG4105TW1 Carbohydrate-selective porin OprB CBI29_02131 ENOG4106JPM 3-dehydroshikimate dehydratase CBI29_02132 ENOG4105FF2 Type I DHQase CBI29_02133 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha CBI29_02134 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta CBI29_02135 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CBI29_02136 ENOG4105D2S major facilitator superfamily CBI29_02137 ENOG4105F2Z 3-oxoadipate enol-lactonase CBI29_02138 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase CBI29_02139 ENOG4105CHU acetyl-coa acetyltransferase CBI29_02140 ENOG4107QNJ CoA-transferase subunit B CBI29_02141 ENOG4107QP7 CoA-transferase subunit A CBI29_02143 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CBI29_02144 ENOG4107VMU Membrane CBI29_02153 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CBI29_02156 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CBI29_02158 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CBI29_02159 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CBI29_02165 ENOG4105C7B Threonine dehydratase CBI29_02167 ENOG4105CZN Potassium uptake protein CBI29_02168 ENOG4105HDD phospholipase CBI29_02170 ENOG4105E0K tonB-dependent siderophore receptor CBI29_02173 ENOG4105PV3 Inner membrane protein yqiJ CBI29_02175 ENOG4105C4M (Ubiquinol oxidase) subunit I CBI29_02176 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CBI29_02179 ENOG41068P6 UPF0319 protein CBI29_02181 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CBI29_02186 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CBI29_02187 ENOG4105C8Y Acetylornithine aminotransferase CBI29_02188 ENOG4105M2J Glutaredoxin CBI29_02190 ENOG4105CC0 LysR family Transcriptional regulator CBI29_02191 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CBI29_02192 ENOG4105CWM branched-chain amino acid transport system II carrier protein CBI29_02197 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CBI29_02198 ENOG4105DE4 1-phosphofructokinase CBI29_02199 ENOG4105DM4 PTS System CBI29_02203 ENOG4105BZU Histidine kinase CBI29_02205 ENOG4105D8V Glucose sorbosone dehydrogenase CBI29_02206 ENOG4108RAV Conserved protein CBI29_02207 ENOG4105CHH sulfate transporter CBI29_02210 ENOG4105C85 amino acid CBI29_02212 ENOG4105F7P transcriptional regulator AsnC family CBI29_02217 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 CBI29_02218 ENOG4105VEJ Heat shock protein CBI29_02220 ENOG4105Y3E Modulates RecA activity (By similarity) CBI29_02222 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CBI29_02227 ENOG4105DZP Membrane-associated zinc metalloprotease CBI29_02229 ENOG4105KNE Phosphatidate cytidylyltransferase CBI29_02230 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CBI29_02234 ENOG4105CUX Signal transduction histidine kinase CBI29_02235 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CBI29_02246 ENOG4105CMR udp-glucose 4-epimerase CBI29_02247 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) CBI29_02251 ENOG4105T38 integral membrane protein CBI29_02254 ENOG4105CVM Molybdenum cofactor synthesis domain protein CBI29_02255 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CBI29_02262 ENOG4108IFG nitrite reductase, (NAD(P)H) CBI29_02263 ENOG4107QZF nitrite reductase NADPH large subunit CBI29_02265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CBI29_02269 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CBI29_02270 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CBI29_02272 ENOG4105D8G Major Facilitator superfamily CBI29_02276 ENOG4105CBC glutamate synthase CBI29_02282 ENOG4105C0A alcohol dehydrogenase CBI29_02284 ENOG4105HSS phospholipase C CBI29_02286 ENOG4107QMP dna polymerase iii subunits gamma and tau CBI29_02291 ENOG4105CHR reductase CBI29_02292 ENOG4105CHU acetyl-coa acetyltransferase CBI29_02294 ENOG4105C5Q Transcriptional regulator CBI29_02295 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CBI29_02296 ENOG4108NIW Leucine export protein LeuE CBI29_02297 ENOG4105EW9 transcriptional regulator AsnC family CBI29_02298 ENOG4105DKK Benzoate CBI29_02300 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CBI29_02304 ENOG41081QV Universal stress protein CBI29_02305 ENOG4105C5H ABC transporter CBI29_02309 ENOG4105CNM Receptor CBI29_02315 ENOG4105CUY Mechanosensitive ion channel CBI29_02317 ENOG4105R8C Transcriptional regulator CBI29_02320 ENOG4105CAT Cytidine monophosphate kinase CBI29_02322 ENOG4105EW9 transcriptional regulator AsnC family CBI29_02323 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) CBI29_02328 ENOG4108D1K outer membrane usher protein CBI29_02331 ENOG4105CD8 aminopeptidase N CBI29_02336 ENOG4107QUV Domain protein CBI29_02337 ENOG4105C0A alcohol dehydrogenase CBI29_02339 ENOG4107RR1 TRANSCRIPTIONal CBI29_02341 ENOG4107R55 ethanolamine transporter CBI29_02342 ENOG4105CPD ethanolamine ammonia-lyase CBI29_02343 ENOG4107FQ9 ethanolamine ammonia-lyase CBI29_02344 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CBI29_02349 ENOG4108RCM Nitroreductase CBI29_02350 ENOG4108TZV Membrane CBI29_02351 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CBI29_02353 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CBI29_02354 ENOG4105K8N protein family UPF0079, ATPase CBI29_02361 ENOG4105DZ2 Transcriptional regulator CBI29_02364 ENOG4105F27 Major Facilitator CBI29_02365 ENOG4105EYW Ion transport protein CBI29_02367 ENOG4107QIJ Aconitate hydratase 2 CBI29_02370 ENOG4105CFU surface antigen CBI29_02371 ENOG4107S74 Lysophospholipid transporter LplT CBI29_02374 ENOG4105CFQ glutamine synthetase CBI29_02375 ENOG4105EEX Two component transcriptional regulator (Winged helix family CBI29_02376 ENOG4105C08 Histidine kinase CBI29_02378 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CBI29_02379 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CBI29_02383 ENOG4105D06 uba thif-type nad fad binding protein CBI29_02384 ENOG4108MEJ flavin reductase domain protein CBI29_02386 ENOG4105C1G acyl-Coa dehydrogenase CBI29_02389 ENOG4105GVF (ABC) transporter CBI29_02390 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CBI29_02391 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CBI29_02394 ENOG4105CC0 LysR family Transcriptional regulator CBI29_02397 ENOG4105DEN Luciferase family CBI29_02399 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD CBI29_02400 ENOG4105CND Glycosyl transferase, family 2 CBI29_02401 ENOG4107BJW polysaccharide deacetylase CBI29_02406 ENOG4105E2S oxidase) subunit II CBI29_02407 ENOG4105BZ9 Cytochrome C oxidase, subunit I CBI29_02408 ENOG4105CCU oxidase (Subunit III) CBI29_02409 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) CBI29_02414 ENOG4105CDU Replicative dna helicase CBI29_02415 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CBI29_02425 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CBI29_02426 ENOG4105DC1 bifunctional purine biosynthesis protein purh CBI29_02427 ENOG4105C12 Phosphoribosylglycinamide synthetase CBI29_02429 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CBI29_02430 ENOG4108UMI ABC transporter, permease CBI29_02431 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CBI29_02433 ENOG4105CK2 sodium dicarboxylate symporter CBI29_02443 ENOG4105ETX regulatoR CBI29_02444 ENOG4105DHQ Histidine kinase CBI29_02445 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CBI29_02447 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CBI29_02455 ENOG4105VT2 5-hydroxyisourate hydrolase CBI29_02457 ENOG4105DY2 Paraquat-inducible protein b CBI29_02458 ENOG4105F1S paraquat-inducible protein a CBI29_02462 ENOG4105CSH Transporter CBI29_02476 ENOG4105JXH GntR family transcriptional regulator CBI29_02479 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CBI29_02481 ENOG4107RSM transcriptional regulator CBI29_02483 ENOG4105D6U Sodium Glutamate Symporter CBI29_02489 ENOG4105H4F exported protein CBI29_02496 ENOG4105C26 Dehydrogenase CBI29_02497 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CBI29_02498 ENOG4105EVZ LysR family transcriptional regulator CBI29_02503 ENOG4105D9P serine threonine protein kinase CBI29_02508 ENOG4105VCC 30S ribosomal protein S21 CBI29_02509 ENOG4105KTH gatB Yqey CBI29_02510 ENOG4105ERG peptidase m48, ste24p CBI29_02511 ENOG4105C5I Dehydrogenase CBI29_02514 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CBI29_02521 ENOG41069NU Nitroreductase CBI29_02523 ENOG4105C1J atp-dependent rna helicase CBI29_02524 ENOG4105VEQ Cold shock protein CBI29_02526 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CBI29_02527 ENOG4105M08 Membrane CBI29_02532 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CBI29_02533 ENOG4105CIN aminoacyl-histidine dipeptidase CBI29_02535 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CBI29_02536 ENOG4105CQC Prephenate dehydratase CBI29_02537 ENOG4105NIV Esterase CBI29_02538 ENOG4105C1G acyl-Coa dehydrogenase CBI29_02539 ENOG4105CK2 sodium dicarboxylate symporter CBI29_02540 ENOG4107QYG anthranilate phosphoribosyltransferase CBI29_02541 ENOG4105VUT cytoplasmic protein CBI29_02542 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CBI29_02543 ENOG4105BZ4 penicillin-binding protein CBI29_02545 ENOG4105M6F mutator MutT protein CBI29_02547 ENOG4105DHQ Histidine kinase CBI29_02548 ENOG4105XJC Two component transcriptional regulator (Winged helix family CBI29_02550 ENOG4107QHF type ii secretion system protein e CBI29_02552 ENOG4108R96 Methyltransferase, YaeB family CBI29_02553 ENOG4105DP0 ferredoxin-NADP reductase CBI29_02554 ENOG4105JAB phenazine biosynthesis protein, phzf family CBI29_02555 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CBI29_02556 ENOG4105CFP Peptidase U32 CBI29_02557 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CBI29_02559 ENOG4108JEH abc transporter atp-binding protein CBI29_02560 ENOG4108JEH abc transporter atp-binding protein CBI29_02561 ENOG4106YG3 ABC transporter CBI29_02562 ENOG4105DSP amino acid AbC transporter CBI29_02563 ENOG4105E89 ABC transporter CBI29_02565 ENOG4105ENT Efflux transporter rnd family, mfp subunit CBI29_02567 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CBI29_02584 ENOG4105DR5 peptidase CBI29_02628 ENOG4105CDU Replicative dna helicase CBI29_02643 ENOG41076J9 exonuclease VIII CBI29_02652 ENOG4105DA5 (ABC) transporter CBI29_02653 ENOG4105E3A (ABC) transporter CBI29_02656 ENOG4105CNI cell division protein FtsW CBI29_02657 ENOG4105CVE Lytic murein transglycosylase CBI29_02665 ENOG4105CE9 30S ribosomal protein S2 CBI29_02666 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CBI29_02668 ENOG4107RNU major facilitator superfamily MFS_1 CBI29_02671 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CBI29_02672 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CBI29_02673 ENOG4107QPN acyl-Coa dehydrogenase CBI29_02676 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CBI29_02677 ENOG4105SYT Methylenetetrahydrofolate reductase CBI29_02678 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CBI29_02679 ENOG4105BZU Histidine kinase CBI29_02680 ENOG4105C6K Malic enzyme CBI29_02682 ENOG4105C0H protease CBI29_02683 ENOG4107QNR UPF0135 protein CBI29_02684 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CBI29_02691 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) CBI29_02693 ENOG4105C5F glutamine synthetase CBI29_02694 ENOG4105DUX Transporter CBI29_02696 ENOG4105DDQ anthranilate synthase CBI29_02697 ENOG4105CD8 aminopeptidase N CBI29_02703 ENOG4105C7W Xanthine dehydrogenase CBI29_02705 ENOG4105EUJ GTP cyclohydrolase i CBI29_02709 ENOG4105NX3 Membrane CBI29_02712 ENOG4105E4F Isochorismate synthase CBI29_02716 ENOG4105BZ1 (ABC) transporter CBI29_02719 ENOG4105WQI isochorismatase CBI29_02720 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CBI29_02721 ENOG4105C0W non-ribosomal peptide synthetase CBI29_02725 ENOG4108IPW abc transporter atp-binding protein CBI29_02730 ENOG4105CEY Amp-dependent synthetase and ligase CBI29_02733 ENOG4105WWK YheO domain protein CBI29_02735 ENOG4105C2I pirin domain protein CBI29_02740 ENOG41060M8 Pfam:PhdYeFM CBI29_02746 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CBI29_02747 ENOG4107QZF nitrite reductase NADPH large subunit CBI29_02748 ENOG4105C26 Dehydrogenase CBI29_02750 ENOG4105C94 Transporter CBI29_02751 ENOG4105C94 Transporter CBI29_02752 ENOG4105H1N peptidase, M24 CBI29_02753 ENOG4105ETT transcriptional Regulator, LysR family CBI29_02755 ENOG4105VCD cytoplasmic protein CBI29_02756 ENOG4105D22 carbon starvation protein CBI29_02758 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CBI29_02760 ENOG41066DG (EAL) domain protein CBI29_02762 ENOG4105DHU Bile acid CBI29_02765 ENOG4105DAN ATP-dependent protease CBI29_02766 ENOG4105EJC lysr family transcriptional regulator CBI29_02767 ENOG4108K5P (LipO)protein CBI29_02771 ENOG4105DZ1 carboxypeptidase CBI29_02772 ENOG4108Z0R Transferase CBI29_02776 ENOG4107QTF adenylosuccinate lyase CBI29_02779 ENOG4105ERU peptidase CBI29_02780 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CBI29_02782 ENOG4105C8U phosphate abc transporter CBI29_02783 ENOG4105CVA phosphate CBI29_02784 ENOG4105C85 amino acid CBI29_02785 ENOG4107RA9 decarboxylase CBI29_02786 ENOG4105F7P transcriptional regulator AsnC family CBI29_02788 ENOG4105DY8 decarboxylase CBI29_02789 ENOG4108JPW Aminotransferase CBI29_02794 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CBI29_02797 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) CBI29_02798 ENOG4105D3G Pseudouridine synthase CBI29_02801 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CBI29_02803 ENOG4105M6W Crispr-associated protein, Csy3 family CBI29_02805 ENOG4105ENG CRISPR-associated protein, Csy1 family CBI29_02806 ENOG4107IIZ CRISPR-associated helicase, Cas3 CBI29_02813 ENOG4105JAB phenazine biosynthesis protein, phzf family CBI29_02814 ENOG4108ETY sodium dicarboxylate symporter CBI29_02815 ENOG4105EGI Transcriptional regulator CBI29_02816 ENOG4105CBP Major Facilitator CBI29_02821 ENOG4108R99 pseudouridine synthase CBI29_02822 ENOG4105E9K Isocitrate dehydrogenase CBI29_02824 ENOG4105DZ1 carboxypeptidase CBI29_02825 ENOG4105CEP NADH dehydrogenase CBI29_02826 ENOG4108YZY peptidylprolyl cis-trans isomerase CBI29_02827 ENOG4105CVP deoxyribo-dipyrimidine photolyase CBI29_02830 ENOG4107R8N Glycosyl transferase, family 2 CBI29_02836 ENOG4105EA8 2-Nitropropane dioxygenase CBI29_02837 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CBI29_02838 ENOG4107QS8 (LipO)protein CBI29_02845 ENOG4105DTR rard protein CBI29_02847 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CBI29_02849 ENOG4105BZU Histidine kinase CBI29_02856 ENOG4105EMU Dehydrogenase CBI29_02857 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase CBI29_02858 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) CBI29_02859 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CBI29_02861 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CBI29_02864 ENOG4105C3F Signal peptidase i CBI29_02867 ENOG4105C0H protease CBI29_02868 ENOG4108IYU L-aspartate oxidase CBI29_02871 ENOG4105HHA aminodeoxychorismate lyase CBI29_02872 ENOG4105YAZ 4-amino-4-deoxychorismate lyase CBI29_02873 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CBI29_02875 ENOG4108I5D sulfate abc transporter CBI29_02877 ENOG4108IJ6 ABC transporter CBI29_02878 ENOG4107R11 Transcriptional regulator CBI29_02881 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CBI29_02882 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CBI29_02885 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CBI29_02888 ENOG4108UKI Enoyl-CoA hydratase CBI29_02889 ENOG4105EGD dinuclear metal center protein, YbgI family CBI29_02891 ENOG4105C2C drug resistance transporter, Bcr CflA CBI29_02892 ENOG4108ETH Formylglycinamide ribotide synthetase CBI29_02896 ENOG4105CH2 amidohydrolase CBI29_02897 ENOG4107YD3 Thioesterase CBI29_02898 ENOG4105E02 MotA TolQ exbB proton channel CBI29_02899 ENOG4105M8F Biopolymer transport protein exbD tolR CBI29_02901 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) CBI29_02902 ENOG4105KCK Peptidoglycan-associated lipoprotein CBI29_02912 ENOG4105C02 permease CBI29_02914 ENOG4108V3E phosphoribosylglycinamide formyltransferase CBI29_02915 ENOG4107R6F Alpha Beta Hydrolase Fold protein CBI29_02916 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CBI29_02918 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CBI29_02919 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CBI29_02920 ENOG4105D60 lipoprotein releasing system transmembrane protein CBI29_02927 ENOG4107KET secretion protein, HlyD family CBI29_02934 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CBI29_02935 ENOG4105C10 Electron transfer flavoprotein CBI29_02936 ENOG4105BZJ Electron transfer flavoprotein CBI29_02937 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CBI29_02938 ENOG4105N14 lysine exporter protein LysE YggA CBI29_02939 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CBI29_02941 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CBI29_02943 ENOG4105C85 amino acid CBI29_02944 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CBI29_02946 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) CBI29_02949 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CBI29_02950 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit CBI29_02951 ENOG4105BZW Glycerate kinase CBI29_02961 ENOG4105CEY Amp-dependent synthetase and ligase CBI29_02964 ENOG4108RRZ Transcription elongation factor GreB CBI29_02968 ENOG4105E4C Lytic transglycosylase catalytic CBI29_02971 ENOG4105BZS acriflavin resistance protein CBI29_02972 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CBI29_02974 ENOG41080IJ Diacylglycerol kinase CBI29_02978 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CBI29_02981 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CBI29_02982 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CBI29_02983 ENOG4105CSH Transporter CBI29_02993 ENOG4105EEI dihydropteroate synthase CBI29_02994 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CBI29_02996 ENOG4105HBR Rna-binding protein CBI29_02999 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CBI29_03000 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CBI29_03003 ENOG41080TK Universal stress protein CBI29_03006 ENOG4105PNM synthesis protein CBI29_03010 ENOG4105EEQ Na H antiporter CBI29_03011 ENOG4105CGZ zinc metallopeptidase CBI29_03012 ENOG4105CKW Inner membrane protein yedI CBI29_03016 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CBI29_03018 ENOG4107QN2 dihydrolipoyl dehydrogenase CBI29_03019 ENOG4105C7S Dehydrogenase CBI29_03020 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CBI29_03021 ENOG4105E33 succinate dehydrogenase CBI29_03023 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein CBI29_03024 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit CBI29_03030 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CBI29_03031 ENOG41084BA UPF0250 protein CBI29_03032 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CBI29_03035 ENOG4105CUB amino acid CBI29_03037 ENOG4105KVH Transcriptional regulator CBI29_03038 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CBI29_03039 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CBI29_03042 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CBI29_03047 ENOG410841Q phosphoesterase PA-phosphatase related protein CBI29_03048 ENOG4105C1P efflux transporter, rnd family, mfp subunit CBI29_03049 ENOG4105BZS acriflavin resistance protein CBI29_03050 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CBI29_03051 ENOG4105K8R UPF0145 protein CBI29_03052 ENOG4105K8R UPF0145 protein CBI29_03056 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CBI29_03060 ENOG4108M0I Transcriptional regulator CBI29_03063 ENOG4105DHQ Histidine kinase CBI29_03064 ENOG4105XJC Two component transcriptional regulator (Winged helix family CBI29_03065 ENOG4105DIJ Phosphoethanolamine transferase CBI29_03069 ENOG4105D78 K07001 NTE family protein CBI29_03072 ENOG4105MSB protein, conserved in bacteria CBI29_03073 ENOG4105CTB Polyprenyl synthetase CBI29_03074 ENOG4105C7F AcnD-accessory protein PrpF CBI29_03075 ENOG4105C85 amino acid CBI29_03129 ENOG4105MEW serine threonine protein phosphatase CBI29_03139 ENOG4105CDU Replicative dna helicase CBI29_03161 ENOG4105CF7 AraC family transcriptional regulator CBI29_03166 ENOG4108X0B nad(p)h dehydrogenase (quinone) CBI29_03168 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein CBI29_03170 ENOG4105D8T Acyltransferase CBI29_03172 ENOG4105C03 ribonuclease CBI29_03173 ENOG4108Z03 MAF-like protein CBI29_03174 ENOG4105VQ7 Rod shape-determining protein MreD CBI29_03175 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CBI29_03176 ENOG4105DFF Rod shape-determining protein mreb CBI29_03177 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CBI29_03179 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CBI29_03185 ENOG4105C7B Threonine dehydratase CBI29_03186 ENOG4105D78 K07001 NTE family protein CBI29_03187 ENOG4105BZG amino acid carrier protein CBI29_03190 ENOG4105C2C drug resistance transporter, Bcr CflA CBI29_03191 ENOG4105EM2 membrane CBI29_03193 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CBI29_03201 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CBI29_03202 ENOG4105WD1 Membrane CBI29_03204 ENOG4106HKS Entericidin EcnA/B family CBI29_03207 ENOG4105D4P Coproporphyrinogen iii oxidase CBI29_03209 ENOG4105CBS Chea signal transduction histidine kinase CBI29_03210 ENOG4105C8Q Methyl-accepting chemotaxis CBI29_03211 ENOG4108ZGA chew protein CBI29_03212 ENOG4105M3Z response regulator CBI29_03213 ENOG4108UNF response regulator CBI29_03218 ENOG4105KWI UPF0339 protein CBI29_03219 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CBI29_03220 ENOG4105K78 MarR family Transcriptional regulator CBI29_03222 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CBI29_03223 ENOG4105T95 Thiol disulfide interChange protein CBI29_03225 ENOG4108N2Y auxin Efflux CBI29_03226 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CBI29_03227 ENOG4105CHB tonB-dependent Receptor CBI29_03228 ENOG4108VX5 3-methyladenine DNA glycosylase CBI29_03230 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CBI29_03234 ENOG4105C2W permease CBI29_03236 ENOG4108IQI permease CBI29_03237 ENOG4105E0Y RtcB Protein CBI29_03239 ENOG4108WHA ompa motb domain protein CBI29_03241 ENOG4105CHU acetyl-coa acetyltransferase CBI29_03243 ENOG410814C multidrug resistance protein CBI29_03245 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CBI29_03246 ENOG4105DZG Dehydrogenase CBI29_03247 ENOG4105TW1 Carbohydrate-selective porin OprB CBI29_03249 ENOG4108R6W Transcriptional regulator, ARAC family CBI29_03250 ENOG4105CHU acetyl-coa acetyltransferase CBI29_03254 ENOG41082BV acetyltransferase CBI29_03257 ENOG4108UT2 hemolysin iii CBI29_03258 ENOG4105CSH Transporter CBI29_03261 ENOG4105D3R alkyl hydroperoxide reductase CBI29_03265 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CBI29_03272 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CBI29_03274 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) CBI29_03275 ENOG4108WBT adenosyltransferase CBI29_03279 ENOG4105CNG UPF0061 protein CBI29_03280 ENOG4105E3W Two component transcriptional regulator (Winged helix family CBI29_03281 ENOG4105EB3 Histidine kinase CBI29_03283 ENOG4105CSU acyl-Coa dehydrogenase CBI29_03284 ENOG4105CSU acyl-Coa dehydrogenase CBI29_03285 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CBI29_03289 ENOG4105UGU tonB-dependent Receptor CBI29_03297 ENOG4108PQP glycosyl transferase group 1 CBI29_03299 ENOG4107BJW polysaccharide deacetylase CBI29_03302 ENOG4105CM2 brancheD-chain amino acid aminotransferase CBI29_03303 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CBI29_03304 ENOG4105BZU Histidine kinase CBI29_03305 ENOG4105ED4 portal protein CBI29_03314 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CBI29_03331 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CBI29_03333 ENOG4106050 phage regulatory protein, rha family CBI29_03342 ENOG4108UUM single-stranded DNA-binding protein CBI29_03343 ENOG41083X2 DNA polymerase III, epsilon subunit CBI29_03352 ENOG4105VIE preprotein translocase, subunit YajC CBI29_03353 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CBI29_03354 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CBI29_03355 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CBI29_03357 ENOG4105FFC UPF0187 protein CBI29_03358 ENOG4105DB7 PHP domain protein CBI29_03360 ENOG4105K9H YciI-like protein CBI29_03366 ENOG4105NAU thioesterase Superfamily protein CBI29_03368 ENOG4107U2T alpha beta CBI29_03369 ENOG4107QPB Beta-lactamase domain protein CBI29_03371 ENOG4107QN2 dihydrolipoyl dehydrogenase CBI29_03375 ENOG4108KHX Diguanylate cyclase CBI29_03376 ENOG4105UYK outer membrane protein a CBI29_03378 ENOG4107RZC phospholipase d CBI29_03380 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CBI29_03384 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CBI29_03385 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CBI29_03386 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CBI29_03388 ENOG4108UJD 30S ribosomal protein S9 CBI29_03389 ENOG4107MKT Stringent starvation protein a CBI29_03390 ENOG4105KB2 stringent starvation protein b CBI29_03394 ENOG4105C1G acyl-Coa dehydrogenase CBI29_03395 ENOG4107QX3 carboxylase CBI29_03398 ENOG4108RZE Tetr family transcriptional regulator CBI29_03399 ENOG4105C1G acyl-Coa dehydrogenase CBI29_03405 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CBI29_03406 ENOG4105D6S protein involved in catabolism of external DNA CBI29_03412 ENOG4105E4C Lytic transglycosylase catalytic CBI29_03414 ENOG4105C9A Phoh family CBI29_03420 ENOG4105CS1 NAD(P)H quinone oxidoreductase CBI29_03421 ENOG4107S2Z UPF0761 membrane protein CBI29_03423 ENOG4108K2B transcriptional regulator CBI29_03424 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CBI29_03433 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CBI29_03434 ENOG4105DGW oligopeptidase A CBI29_03435 ENOG4105VKU nucleicacid-binding protein CBI29_03443 ENOG4105C1G acyl-Coa dehydrogenase CBI29_03448 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CBI29_03450 ENOG41067V7 50S ribosomal protein L36 CBI29_03451 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CBI29_03473 ENOG41089BK Glutamine amido-transferase CBI29_03474 ENOG4105C28 cystathionine CBI29_03475 ENOG4105D7A ATP-binding protein CBI29_03477 ENOG4105KPV Transcriptional regulator CBI29_03480 ENOG4105CK2 sodium dicarboxylate symporter CBI29_03481 ENOG4105C29 acyl-CoA thioesterase CBI29_03485 ENOG4105CB5 ATP-dependent DNA helicase recG CBI29_03486 ENOG4105MJ2 Competence protein CBI29_03488 ENOG4108URH decarboxylase CBI29_03489 ENOG4105D7N magnesium and cobalt transport protein CorA CBI29_03491 ENOG4105E3I toluene tolerance CBI29_03493 ENOG4105CY3 ABC transporter, permease CBI29_03494 ENOG4105DHJ ABC, transporter CBI29_03496 ENOG4105C1J atp-dependent rna helicase CBI29_03497 ENOG4105ECY inositol monophosphatase CBI29_03500 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CBI29_03503 ENOG4105CSU acyl-Coa dehydrogenase CBI29_03505 ENOG41067S9 phage shock protein C, PspC CBI29_03506 ENOG4105W87 Cbs domain CBI29_03519 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CBI29_03524 ENOG4105C26 Dehydrogenase CBI29_03526 ENOG4105C8Y Acetylornithine aminotransferase CBI29_03527 ENOG4105D82 Glutamate dehydrogenase CBI29_03528 ENOG4108IQI permease CBI29_03535 ENOG4105IPI Membrane CBI29_03536 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CBI29_03537 ENOG4105EM2 membrane CBI29_03538 ENOG4107QF7 multi-drug CBI29_03540 ENOG4105NF4 modulator of drug activity CBI29_03541 ENOG4105VRH Antibiotic biosynthesis monooxygenase CBI29_03543 ENOG4105CQB FAD linked oxidase domain protein CBI29_03544 ENOG4108JQ1 Dehydrogenase CBI29_03549 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CBI29_03550 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) CBI29_03551 ENOG4107IFA Lipase (EC 3.1.1.3) CBI29_03554 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CBI29_03564 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CBI29_03566 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CBI29_03567 ENOG4105KME endoribonuclease L-psp CBI29_03569 ENOG4108UQY Iron-storage protein CBI29_03570 ENOG4108YSG O-Antigen polymerase CBI29_03573 ENOG4105HA9 of methanol dehydrogenase type CBI29_03574 ENOG4108V0P LemA family CBI29_03576 ENOG4105BZ8 glutamate synthase CBI29_03577 ENOG4105CBC glutamate synthase CBI29_03581 ENOG4105E4G Type IV pilus CBI29_03586 ENOG4108JQC penicillin-binding protein 1A CBI29_03587 ENOG4105DHI Methyltransferase CBI29_03590 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CBI29_03591 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CBI29_03592 ENOG4105CJN penicillin-binding protein CBI29_03595 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CBI29_03600 ENOG4108IQI permease CBI29_03613 ENOG4105C5H ABC transporter CBI29_03615 ENOG4105PDP Short chain dehydrogenase CBI29_03616 ENOG4105CHH sulfate transporter CBI29_03617 ENOG4105BZM domain protein CBI29_03618 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CBI29_03619 ENOG4105E0F Histidine kinase CBI29_03620 ENOG4105CYC Transferase CBI29_03626 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CBI29_03634 ENOG4105CUV Homoserine Kinase CBI29_03645 ENOG4108Z9I -acetyltransferase CBI29_03647 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CBI29_03648 ENOG4105KVH Transcriptional regulator CBI29_03651 ENOG4105KVH Transcriptional regulator CBI29_03654 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) CBI29_03655 ENOG4105CPC Aldo Keto reductase CBI29_03659 ENOG4106NZI LysR family Transcriptional regulator CBI29_03660 ENOG4105D94 Major Facilitator Superfamily CBI29_03666 ENOG4105EUB pirin domain protein CBI29_03667 ENOG4105CHJ isochorismatase hydrolase CBI29_03669 ENOG4105C26 Dehydrogenase CBI29_03670 ENOG4108JPW Aminotransferase CBI29_03672 ENOG4105C85 amino acid CBI29_03674 ENOG4108UMN azlc family CBI29_03676 ENOG4108UUM single-stranded DNA-binding protein CBI29_03677 ENOG4107RDB Major Facilitator CBI29_03679 ENOG4105DWF phosphomethylpyrimidine kinase CBI29_03680 ENOG4105RA2 Membrane CBI29_03682 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CBI29_03683 ENOG4108WUH Transcriptional regulator, TetR family CBI29_03684 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CBI29_03685 ENOG4105BZU Histidine kinase CBI29_03687 ENOG4105C94 Transporter CBI29_03689 ENOG4107QN1 sodium solute CBI29_03690 ENOG41062QD Membrane CBI29_03691 ENOG4105BZU Histidine kinase CBI29_03694 ENOG4108UZX fmn reductase CBI29_03695 ENOG4105FBW Monooxygenase CBI29_03697 ENOG4108W2Y isochorismatase CBI29_03698 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CBI29_03700 ENOG4105D64 Mechanosensitive ion channel CBI29_03702 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CBI29_03703 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CBI29_03706 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CBI29_03708 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CBI29_03711 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CBI29_03714 ENOG4105E0K tonB-dependent siderophore receptor CBI29_03717 ENOG4107QSN dihydrolipoamide acetyltransferase CBI29_03718 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CBI29_03719 ENOG41063SB peptidase CBI29_03722 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CBI29_03723 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CBI29_03724 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) CBI29_03728 ENOG4105D7Z glutathione synthase CBI29_03732 ENOG4105CGK Exodeoxyribonuclease III CBI29_03733 ENOG4105KUZ arsenate reductase CBI29_03736 ENOG4105BZU Histidine kinase CBI29_03737 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CBI29_03743 ENOG41084YZ Hydrolase CBI29_03746 ENOG41061H0 Monooxygenase CBI29_03748 ENOG4108Z2U ureidoglycolate hydrolase CBI29_03749 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CBI29_03750 ENOG4105IPS esterase CBI29_03756 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CBI29_03757 ENOG4105CS6 Rhs element vgr protein CBI29_03759 ENOG4105D9M gamma-glutamylcysteine synthetase CBI29_03762 ENOG4106BRA Membrane CBI29_03763 ENOG4105CHM Aminotransferase CBI29_03764 ENOG4107QJQ Mate efflux family protein CBI29_03767 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CBI29_03768 ENOG4105BZU Histidine kinase CBI29_03771 ENOG4105KHC sulfurtransferase CBI29_03778 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CBI29_03781 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CBI29_03782 ENOG4108ZAI phosphatidylglycerophosphatase a CBI29_03784 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CBI29_03787 ENOG4105NI8 Cytosine-specific methyltransferase CBI29_03789 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CBI29_03792 ENOG41088SP formiminoglutamate hydrolase CBI29_03794 ENOG4105C85 amino acid CBI29_03797 ENOG41090B9 response to stress CBI29_03798 ENOG4105CZE histidine utilization repressor CBI29_03800 ENOG4105CKI cobalamin synthesis protein CBI29_03802 ENOG4105C85 amino acid CBI29_03804 ENOG4108RXX maleylacetoacetate isomerase CBI29_03808 ENOG4105EWC Purine nucleoside phosphorylase CBI29_03809 ENOG4107QI1 Mate efflux family protein CBI29_03810 ENOG4105C09 Bile acid CBI29_03811 ENOG4108RWI nicotinamidase CBI29_03812 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CBI29_03816 ENOG4105S64 Formate nitrite transporter CBI29_03817 ENOG4105D1H recombination factor protein RarA CBI29_03818 ENOG4105D8V Glucose sorbosone dehydrogenase CBI29_03819 ENOG4108ZZ3 UPF0260 protein CBI29_03823 ENOG4105CEN a g-specific adenine glycosylase CBI29_03826 ENOG4108R3E Dna-3-methyladenine glycosylase i CBI29_03827 ENOG4105DQ4 alcohol dehydrogenase CBI29_03830 ENOG4105HEI LysR family (Transcriptional regulator CBI29_03831 ENOG4105CV8 reductase CBI29_03832 ENOG4105F27 Major Facilitator CBI29_03839 ENOG4105DJY efflux transporter, rnd family, mfp subunit CBI29_03840 ENOG4108IG5 Transcriptional regulator CBI29_03842 ENOG4105C2W permease CBI29_03843 ENOG4108W5M transcriptional regulator CBI29_03848 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CBI29_03850 ENOG4105C8J )-transporter CBI29_04102 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CBI29_04307 ENOG4105UGU tonB-dependent Receptor CBI29_04412 ENOG4105KK6 nuclease CBI29_04414 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS CBI29_04425 ENOG4105FA0 parb-like partition protein CBI29_04429 ENOG4105CDW Resistance protein CBI29_04451 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CBI29_04469 ENOG4105CHH sulfate transporter CBI29_04472 ENOG4105D85 methylase CBI29_04473 ENOG4105F6A helicase CBI29_04474 ENOG4108HWY Beta-lactamase CBI29_04489 ENOG4105K5T PilT protein CBI29_04495 ENOG4105T95 Thiol disulfide interChange protein CBI29_04511 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)