locus-tag	class	description
NT399_00010	COG0592	DNA-directed DNA polymerase activity
NT399_00020	COG0187	DNA topoisomerase II activity
NT399_00030	COG0586	Pfam SNARE associated Golgi protein
NT399_00035	COG0488	(ABC) transporter
NT399_00060	COG0596	Alpha beta hydrolase
NT399_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NT399_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NT399_00115	COG1047	Peptidyl-prolyl cis-trans
NT399_00125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NT399_00130	COG0196	riboflavin kinase activity
NT399_00140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NT399_00145	COG1309	transcriptional regulator
NT399_00150	COG1116	anion transmembrane transporter activity
NT399_00155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NT399_00160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NT399_00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NT399_00170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NT399_00190	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_00195	COG0546	phosphoglycolate phosphatase activity
NT399_00255	COG3023	N-Acetylmuramoyl-L-alanine amidase
NT399_00260	COG0728	peptidoglycan biosynthetic process
NT399_00285	COG1596	polysaccharide export
NT399_00290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NT399_00300	COG1216	Glycosyl transferase, family 2
NT399_00300	COG1442	glycosyl transferase family 8
NT399_00310	COG0297	glycogen (starch) synthase activity
NT399_00310	COG0438	transferase activity, transferring glycosyl groups
NT399_00320	COG1216	Glycosyl transferase, family 2
NT399_00330	COG1216	Glycosyl transferase, family 2
NT399_00335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NT399_00340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NT399_00355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NT399_00365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NT399_00375	COG2186	Transcriptional regulator
NT399_00385	COG0277	FAD linked oxidase domain protein
NT399_00390	COG1448	Aminotransferase
NT399_00400	COG1802	Transcriptional regulator
NT399_00415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NT399_00450	COG0564	pseudouridine synthase activity
NT399_00490	COG0251	oxidation-reduction process
NT399_00495	COG1113	amino acid transport
NT399_00500	COG1113	amino acid transport
NT399_00520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NT399_00525	COG1960	acyl-CoA dehydrogenase activity
NT399_00530	COG1024	Enoyl-CoA hydratase
NT399_00535	COG1024	Enoyl-CoA hydratase
NT399_00550	COG3293	Transposase
NT399_00575	COG0271	Belongs to the BolA IbaG family
NT399_00585	COG1192	Involved in chromosome partitioning
NT399_00600	COG0586	Pfam SNARE associated Golgi protein
NT399_00605	COG2259	Doxx family
NT399_00610	COG4399	Belongs to the UPF0754 family
NT399_00615	COG0519	Catalyzes the synthesis of GMP from XMP
NT399_00615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NT399_00660	COG0281	malic enzyme
NT399_00665	COG2837	iron assimilation
NT399_00670	COG1280	lysine exporter protein (LysE YggA)
NT399_00675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NT399_00680	COG1121	(ABC) transporter
NT399_00745	COG0386	Belongs to the glutathione peroxidase family
NT399_00760	COG1309	transcriptional regulator
NT399_00765	COG0697	spore germination
NT399_00775	COG0758	DNA mediated transformation
NT399_00845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NT399_00855	COG0655	NAD(P)H dehydrogenase (quinone) activity
NT399_00895	COG4452	Inner membrane protein CreD
NT399_00900	COG2205	protein histidine kinase activity
NT399_00905	COG0745	RESPONSE REGULATOR receiver
NT399_00915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NT399_00925	COG2814	Major facilitator Superfamily
NT399_00935	COG1253	flavin adenine dinucleotide binding
NT399_00940	COG3012	SEC-C Motif Domain Protein
NT399_00945	COG2860	membrane
NT399_00950	COG0477	Major facilitator Superfamily
NT399_00960	COG0318	PFAM AMP-dependent synthetase and ligase
NT399_00975	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NT399_00995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NT399_01010	COG0606	chelatase, subunit chli
NT399_01020	COG0347	Belongs to the P(II) protein family
NT399_01025	COG0004	ammonium transporteR
NT399_01035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NT399_01035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NT399_01075	COG0795	lipopolysaccharide-transporting ATPase activity
NT399_01080	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NT399_01085	COG0793	Belongs to the peptidase S41A family
NT399_01100	COG2197	response regulator
NT399_01110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NT399_01120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NT399_01125	COG4974	Belongs to the 'phage' integrase family
NT399_01150	COG0772	Belongs to the SEDS family
NT399_01155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NT399_01160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NT399_01165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NT399_01190	COG0697	spore germination
NT399_01195	COG1538	Outer membrane efflux protein
NT399_01215	COG3275	phosphorelay sensor kinase activity
NT399_01225	COG0181	hydroxymethylbilane synthase activity
NT399_01270	COG1716	ATPase activity
NT399_01275	COG0546	phosphoglycolate phosphatase activity
NT399_01370	COG0596	Alpha beta hydrolase
NT399_01375	COG2056	Na+-H+ antiporter family
NT399_01390	COG0326	Molecular chaperone. Has ATPase activity
NT399_01405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NT399_01455	COG3293	Transposase
NT399_01480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NT399_01485	COG2169	Transcriptional regulator
NT399_01485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NT399_01515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NT399_01525	COG0497	DNA recombination
NT399_01540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NT399_01550	COG0237	dephospho-CoA kinase activity
NT399_01600	COG0195	Participates in both transcription termination and antitermination
NT399_01615	COG1320	monovalent cation:proton antiporter activity
NT399_01620	COG2212	antiporter activity
NT399_01625	COG1863	multisubunit Na H antiporter MnhE subunit
NT399_01630	COG0651	ATP synthesis coupled electron transport
NT399_01635	COG1006	Multisubunit Na H antiporter MnhC subunit
NT399_01640	COG2111	Na H antiporter
NT399_01640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NT399_01655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NT399_01660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NT399_01675	COG2226	methyltransferase
NT399_01695	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NT399_01700	COG1074	ATP-dependent DNA helicase activity
NT399_01705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NT399_01710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NT399_01725	COG0598	Magnesium transport protein CorA
NT399_01730	COG0789	Transcriptional regulator
NT399_01735	COG0484	heat shock protein binding
NT399_01750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NT399_01750	COG0475	glutathione-regulated potassium exporter activity
NT399_01755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NT399_01775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NT399_01785	COG4535	Mg2 and Co2 transporter CorC
NT399_01790	COG0425	Belongs to the sulfur carrier protein TusA family
NT399_01800	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NT399_01800	COG0644	oxidoreductase
NT399_01810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NT399_01825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NT399_01830	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NT399_01840	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
NT399_01840	COG0493	'glutamate synthase
NT399_01910	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NT399_01925	COG0534	Mate efflux family protein
NT399_01935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NT399_01940	COG4221	oxidoreductase activity
NT399_01945	COG0583	DNA-binding transcription factor activity
NT399_01960	COG0318	PFAM AMP-dependent synthetase and ligase
NT399_01965	COG1530	ribonuclease E activity
NT399_01975	COG0546	phosphoglycolate phosphatase activity
NT399_01980	COG2378	regulation of single-species biofilm formation
NT399_01995	COG0583	DNA-binding transcription factor activity
NT399_02025	COG0583	DNA-binding transcription factor activity
NT399_02050	COG0473	3-isopropylmalate dehydrogenase activity
NT399_02105	COG1301	dicarboxylic acid transport
NT399_02115	COG1560	Kdo2-lipid A biosynthetic process
NT399_02120	COG1280	lysine exporter protein (LysE YggA)
NT399_02130	COG0488	(ABC) transporter
NT399_02135	COG2900	Belongs to the SlyX family
NT399_02145	COG1733	regulation of RNA biosynthetic process
NT399_02170	COG0210	DNA helicase
NT399_02175	COG0724	RNA recognition motif
NT399_02195	COG4651	solute:proton antiporter activity
NT399_02195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NT399_02220	COG0788	formyltetrahydrofolate deformylase activity
NT399_02320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NT399_02320	COG2813	Specifically methylates the guanine in position
NT399_02330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NT399_02340	COG4774	siderophore transport
NT399_02350	COG0740	serine-type endopeptidase activity
NT399_02370	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NT399_02370	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NT399_02375	COG0280	phosphate acetyltransferase
NT399_02375	COG0857	belongs to the CobB CobQ family
NT399_02380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NT399_02390	COG0800	Aldolase
NT399_02400	COG3265	gluconokinase activity
NT399_02405	COG1012	belongs to the aldehyde dehydrogenase family
NT399_02415	COG2267	carboxylic ester hydrolase activity
NT399_02430	COG0793	Belongs to the peptidase S41A family
NT399_02465	COG1426	Protein conserved in bacteria
NT399_02505	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NT399_02515	COG1162	GTPase activity
NT399_02520	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NT399_02535	COG1538	Outer membrane efflux protein
NT399_02540	COG1136	(ABC) transporter
NT399_02540	COG0577	efflux transmembrane transporter activity
NT399_02545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NT399_02570	COG0028	Belongs to the TPP enzyme family
NT399_02575	COG0440	acetolactate synthase activity
NT399_02720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NT399_02735	COG0084	hydrolase, TatD family'
NT399_02745	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NT399_02755	COG0583	DNA-binding transcription factor activity
NT399_02765	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NT399_02770	COG2814	Major facilitator Superfamily
NT399_02780	COG0697	spore germination
NT399_02810	COG3622	Belongs to the hyi family
NT399_02815	COG2084	Dehydrogenase
NT399_02820	COG1024	Enoyl-CoA hydratase
NT399_02825	COG0784	Response regulator, receiver
NT399_02825	COG2205	protein histidine kinase activity
NT399_02825	COG5002	protein histidine kinase activity
NT399_02845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NT399_02855	COG3956	TIGRFAM MazG family protein
NT399_02860	COG1555	photosystem II stabilization
NT399_02865	COG0617	tRNA 3'-terminal CCA addition
NT399_02870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NT399_02890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NT399_02895	COG3028	Belongs to the UPF0307 family
NT399_02900	COG0318	PFAM AMP-dependent synthetase and ligase
NT399_02915	COG0625	glutathione transferase activity
NT399_02920	COG1238	metal cluster binding
NT399_02965	COG0072	phenylalanine-tRNA ligase activity
NT399_02995	COG0248	Ppx GppA phosphatase
NT399_03005	COG0037	tRNA processing
NT399_03045	COG1764	response to oxidative stress
NT399_03050	COG1846	Transcriptional regulator
NT399_03060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NT399_03120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NT399_03125	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NT399_03130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NT399_03140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NT399_03175	COG1214	PFAM Peptidase M22, glycoprotease
NT399_03200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NT399_03205	COG0561	phosphatase activity
NT399_03215	COG2132	Multicopper oxidase
NT399_03220	COG3667	copper resistance
NT399_03235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NT399_03240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NT399_03245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NT399_03275	COG1063	alcohol dehydrogenase
NT399_03280	COG0583	DNA-binding transcription factor activity
NT399_03285	COG1960	acyl-CoA dehydrogenase activity
NT399_03290	COG2814	Major facilitator Superfamily
NT399_03295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NT399_03300	COG1309	transcriptional regulator
NT399_03315	COG1053	succinate dehydrogenase
NT399_03320	COG0583	DNA-binding transcription factor activity
NT399_03335	COG0583	DNA-binding transcription factor activity
NT399_03345	COG0583	DNA-binding transcription factor activity
NT399_03360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NT399_03375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NT399_03395	COG0745	RESPONSE REGULATOR receiver
NT399_03435	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NT399_03465	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NT399_03470	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NT399_03490	COG0583	DNA-binding transcription factor activity
NT399_03510	COG0668	transmembrane transport
NT399_03520	COG2081	HI0933 family
NT399_03525	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NT399_03555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NT399_03555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NT399_03565	COG0489	protein tyrosine kinase activity
NT399_03615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NT399_03625	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NT399_03640	COG0730	response to heat
NT399_03650	COG1196	nuclear chromosome segregation
NT399_03670	COG2223	nitrite transmembrane transporter activity
NT399_03675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NT399_03680	COG1877	trehalose-phosphatase activity
NT399_03685	COG0596	Alpha beta hydrolase
NT399_03685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NT399_03685	COG2226	methyltransferase
NT399_03700	COG4106	trans-aconitate 2-methyltransferase activity
NT399_03715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NT399_03720	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NT399_03725	COG0009	L-threonylcarbamoyladenylate synthase
NT399_03730	COG3101	peptidyl-lysine hydroxylation
NT399_03735	COG1399	metal-binding, possibly nucleic acid-binding protein
NT399_03760	COG1652	LysM domain
NT399_03765	COG0352	thiamine-phosphate diphosphorylase activity
NT399_03765	COG0351	phosphomethylpyrimidine kinase
NT399_03765	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NT399_03775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NT399_03805	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NT399_03835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NT399_03850	COG0358	DNA primase activity
NT399_03860	COG0564	pseudouridine synthase activity
NT399_03885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NT399_03915	COG0473	3-isopropylmalate dehydrogenase activity
NT399_03925	COG0657	acetylesterase activity
NT399_03935	COG1012	belongs to the aldehyde dehydrogenase family
NT399_03955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NT399_03955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NT399_03970	COG1981	membrane
NT399_04015	COG0456	acetyltransferase
NT399_04025	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NT399_04030	COG0492	ferredoxin-NADP+ reductase activity
NT399_04035	COG1674	ftsk spoiiie
NT399_04035	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NT399_04040	COG1280	lysine exporter protein (LysE YggA)
NT399_04055	COG2894	cell division
NT399_04070	COG0204	Acyl-transferase
NT399_04075	COG2885	chlorophyll binding
NT399_04080	COG0210	DNA helicase
NT399_04090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NT399_04105	COG0121	glutamine amidotransferase
NT399_04125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NT399_04130	COG0735	belongs to the Fur family
NT399_04155	COG0420	3'-5' exonuclease activity
NT399_04175	COG1090	epimerase
NT399_04190	COG2050	protein possibly involved in aromatic compounds catabolism
NT399_04200	COG2814	Major facilitator Superfamily
NT399_04205	COG0405	Gamma-glutamyltransferase
NT399_04215	COG0582	viral genome integration into host DNA
NT399_04315	COG0531	amino acid
NT399_04320	COG2040	homocysteine
NT399_04345	COG1309	transcriptional regulator
NT399_04350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NT399_04355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NT399_04365	COG1607	acyl-coa hydrolase
NT399_04375	COG0523	cobalamin synthesis protein
NT399_04385	COG4681	YaeQ
NT399_04395	COG0726	polysaccharide deacetylase
NT399_04395	COG1649	PFAM Uncharacterised BCR, COG1649
NT399_04400	COG1215	transferase activity, transferring glycosyl groups
NT399_04410	COG1024	Enoyl-CoA hydratase
NT399_04425	COG1414	Transcriptional regulator
NT399_04445	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_04460	COG2271	Major facilitator Superfamily
NT399_04470	COG2267	carboxylic ester hydrolase activity
NT399_04475	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_04490	COG0028	Belongs to the TPP enzyme family
NT399_04500	COG0477	Major facilitator Superfamily
NT399_04505	COG0242	peptide deformylase activity
NT399_04510	COG2066	Belongs to the glutaminase family
NT399_04515	COG2207	Transcriptional regulator
NT399_04520	COG2223	nitrite transmembrane transporter activity
NT399_04535	COG0583	DNA-binding transcription factor activity
NT399_04540	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_04545	COG2271	Major facilitator Superfamily
NT399_04550	COG3959	Transketolase, thiamine diphosphate binding domain
NT399_04555	COG3958	Transketolase
NT399_04580	COG0306	phosphate transporter
NT399_04600	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NT399_04645	COG4181	ATPase activity
NT399_04650	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NT399_04680	COG0583	DNA-binding transcription factor activity
NT399_04690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NT399_04695	COG1773	rubredoxin
NT399_04745	COG2851	Citrate transporter
NT399_04750	COG1253	flavin adenine dinucleotide binding
NT399_04790	COG0804	urea catabolic process
NT399_04800	COG0830	nickel cation binding
NT399_04815	COG0742	ribosomal rna small subunit methyltransferase
NT399_04820	COG0768	penicillin binding
NT399_04845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NT399_04850	COG2878	Part of a membrane complex involved in electron transport
NT399_04855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NT399_04865	COG3384	dioxygenase
NT399_04890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NT399_04930	COG0006	proline dipeptidase activity
NT399_04935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NT399_04940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NT399_04960	COG1279	arginine transmembrane transporter activity
NT399_04965	COG0583	DNA-binding transcription factor activity
NT399_05005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NT399_05010	COG1388	LysM domain
NT399_05010	COG0741	lytic transglycosylase activity
NT399_05010	COG1388	LysM domain
NT399_05010	COG0741	lytic transglycosylase activity
NT399_05020	COG4174	ABC transporter (Permease)
NT399_05025	COG4239	(ABC) transporter, permease
NT399_05030	COG4172	Belongs to the ABC transporter superfamily
NT399_05050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NT399_05060	COG4251	negative regulation of phosphorylation
NT399_05060	COG5001	Diguanylate cyclase
NT399_05060	COG2203	Gaf domain
NT399_05060	COG3706	GGDEF domain
NT399_05070	COG0446	pyridine nucleotide-disulphide oxidoreductase
NT399_05070	COG1902	pentaerythritol trinitrate reductase activity
NT399_05105	COG1113	amino acid transport
NT399_05115	COG0531	amino acid
NT399_05135	COG1012	belongs to the aldehyde dehydrogenase family
NT399_05155	COG2072	flavoprotein involved in K transport
NT399_05165	COG2252	PERMEase
NT399_05170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NT399_05175	COG3038	cytochrome b561
NT399_05185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NT399_05195	COG0527	aspartate kinase activity
NT399_05205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NT399_05215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NT399_05230	COG0667	Aldo Keto reductase
NT399_05245	COG1765	OsmC-like protein
NT399_05260	COG0542	response to heat
NT399_05320	COG0625	glutathione transferase activity
NT399_05325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NT399_05345	COG3634	alkyl hydroperoxide reductase activity
NT399_05355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NT399_05365	COG0450	alkyl hydroperoxide reductase
NT399_05370	COG1643	Atp-dependent helicase
NT399_05385	COG2814	Major facilitator Superfamily
NT399_05390	COG3135	benzoate transporter
NT399_05395	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_05400	COG0543	2 iron, 2 sulfur cluster binding
NT399_05400	COG0633	Ferredoxin
NT399_05410	COG4638	Rieske (2fe-2S)
NT399_05420	COG0583	DNA-binding transcription factor activity
NT399_05430	COG2871	sodium ion transport
NT399_05515	COG1570	exodeoxyribonuclease VII activity
NT399_05550	COG1280	lysine exporter protein (LysE YggA)
NT399_05555	COG1278	Cold shock
NT399_05585	COG3293	Transposase
NT399_05725	COG3728	DNA packaging
NT399_05725	COG5484	DNA packaging
NT399_05840	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NT399_05840	COG0517	IMP dehydrogenase activity
NT399_05845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NT399_05855	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NT399_05860	COG1137	ATPase activity
NT399_05865	COG1538	Outer membrane efflux protein
NT399_05895	COG4122	O-methyltransferase activity
NT399_05905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NT399_05940	COG0598	Magnesium transport protein CorA
NT399_05965	COG1250	3-hydroxyacyl-CoA dehydrogenase
NT399_06035	COG0583	DNA-binding transcription factor activity
NT399_06040	COG1914	H( )-stimulated, divalent metal cation uptake system
NT399_06060	COG4770	biotin carboxylase activity
NT399_06065	COG0038	chloride channel
NT399_06115	COG2801	Transposase and inactivated derivatives
NT399_06120	COG2801	Transposase and inactivated derivatives
NT399_06140	COG1063	alcohol dehydrogenase
NT399_06155	COG0439	Biotin carboxylase
NT399_06160	COG2249	NAD(P)H dehydrogenase (quinone) activity
NT399_06165	COG1733	regulation of RNA biosynthetic process
NT399_06175	COG0864	Transcriptional regulator
NT399_06185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NT399_06190	COG1116	anion transmembrane transporter activity
NT399_06220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NT399_06240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NT399_06265	COG1012	belongs to the aldehyde dehydrogenase family
NT399_06270	COG0531	amino acid
NT399_06275	COG1760	l-serine dehydratase
NT399_06280	COG1012	belongs to the aldehyde dehydrogenase family
NT399_06280	COG2030	dehydratase
NT399_06285	COG3396	Phenylacetate-CoA oxygenase
NT399_06290	COG3460	Phenylacetate-CoA oxygenase
NT399_06295	COG3396	Phenylacetate-CoA oxygenase
NT399_06300	COG2151	metal-sulfur cluster biosynthetic enzyme
NT399_06305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NT399_06310	COG1024	Enoyl-CoA hydratase
NT399_06315	COG1024	Enoyl-CoA hydratase
NT399_06320	COG1250	3-hydroxyacyl-CoA dehydrogenase
NT399_06325	COG0183	Belongs to the thiolase family
NT399_06330	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
NT399_06335	COG3327	negative regulation of DNA-templated transcription, initiation
NT399_06355	COG3038	cytochrome b561
NT399_06360	COG0154	amidase activity
NT399_06370	COG4638	Rieske (2fe-2S)
NT399_06385	COG2814	Major facilitator Superfamily
NT399_06405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NT399_06410	COG2814	Major facilitator Superfamily
NT399_06445	COG0583	DNA-binding transcription factor activity
NT399_06455	COG1414	Transcriptional regulator
NT399_06460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NT399_06470	COG1840	ABC-type Fe3 transport system, periplasmic component
NT399_06475	COG3842	ATPase activity
NT399_06490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NT399_06495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NT399_06515	COG0583	DNA-binding transcription factor activity
NT399_06525	COG4770	biotin carboxylase activity
NT399_06545	COG0583	DNA-binding transcription factor activity
NT399_06595	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_06615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NT399_06635	COG0784	Response regulator, receiver
NT399_06635	COG2205	protein histidine kinase activity
NT399_06675	COG0765	amino acid transport
NT399_06680	COG0765	amino acid transport
NT399_06690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NT399_06695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NT399_06705	COG1280	lysine exporter protein (LysE YggA)
NT399_06710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NT399_06715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NT399_06720	COG1045	serine acetyltransferase
NT399_06730	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_06735	COG0583	DNA-binding transcription factor activity
NT399_06740	COG0625	glutathione transferase activity
NT399_06745	COG0625	glutathione transferase activity
NT399_06750	COG0583	DNA-binding transcription factor activity
NT399_06760	COG1346	cytolysis
NT399_06780	COG2814	Major facilitator Superfamily
NT399_06790	COG0583	DNA-binding transcription factor activity
NT399_06800	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NT399_06805	COG3052	prosthetic group binding
NT399_06825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NT399_06845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NT399_06855	COG1294	oxidase, subunit
NT399_06860	COG1271	oxidase subunit
NT399_06880	COG0477	Major facilitator Superfamily
NT399_06890	COG4521	taurine ABC transporter
NT399_06895	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NT399_06900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NT399_06905	COG2175	clavaminate synthase activity
NT399_06915	COG1953	Uracil, thiamine, allantoin
NT399_06935	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NT399_06950	COG0640	Transcriptional regulator
NT399_06955	COG3328	transposase activity
NT399_06960	COG0798	PFAM Bile acid sodium symporter
NT399_06965	COG0583	DNA-binding transcription factor activity
NT399_06980	COG3634	alkyl hydroperoxide reductase activity
NT399_07020	COG0436	Aminotransferase
NT399_07030	COG0386	Belongs to the glutathione peroxidase family
NT399_07070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NT399_07095	COG0012	GTP binding
NT399_07100	COG2011	ABC-type metal ion transport system permease component
NT399_07105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NT399_07110	COG1464	Belongs to the NlpA lipoprotein family
NT399_07115	COG1464	Belongs to the NlpA lipoprotein family
NT399_07145	COG0765	amino acid transport
NT399_07150	COG0765	amino acid transport
NT399_07155	COG1126	abc transporter atp-binding protein
NT399_07165	COG1522	sequence-specific DNA binding
NT399_07180	COG1309	transcriptional regulator
NT399_07205	COG0583	DNA-binding transcription factor activity
NT399_07230	COG0697	spore germination
NT399_07255	COG3121	Chaperone
NT399_07260	COG3539	Fimbrial protein
NT399_07285	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NT399_07285	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NT399_07330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NT399_07340	COG2353	YceI-like domain
NT399_07350	COG3698	Phosphodiester glycosidase
NT399_07365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NT399_07370	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NT399_07370	COG0506	proline dehydrogenase activity
NT399_07370	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NT399_07380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NT399_07385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NT399_07405	COG1132	(ABC) transporter
NT399_07410	COG3122	Protein conserved in bacteria
NT399_07415	COG3619	membrane
NT399_07425	COG0640	Transcriptional regulator
NT399_07435	COG2850	peptidyl-arginine hydroxylation
NT399_07440	COG0424	maF-like protein
NT399_07460	COG0191	fructose-bisphosphate aldolase activity
NT399_07465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NT399_07480	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NT399_07490	COG1192	Involved in chromosome partitioning
NT399_07495	COG1475	DNA binding
NT399_07500	COG0811	peptide transport
NT399_07510	COG1132	(ABC) transporter
NT399_07515	COG1663	tetraacyldisaccharide 4'-kinase activity
NT399_07535	COG0084	hydrolase, TatD family'
NT399_07600	COG0776	regulation of translation
NT399_07630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NT399_07635	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NT399_07685	COG0339	signal peptide processing
NT399_07695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NT399_07730	COG0702	epimerase
NT399_07735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NT399_07755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NT399_07785	COG0316	Belongs to the HesB IscA family
NT399_07790	COG0822	iron-sulfur transferase activity
NT399_07815	COG0776	regulation of translation
NT399_07820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NT399_07830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NT399_07835	COG1960	acyl-CoA dehydrogenase activity
NT399_07840	COG1960	acyl-CoA dehydrogenase activity
NT399_07855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NT399_07870	COG2814	Major facilitator Superfamily
NT399_07890	COG4264	IucA IucC family
NT399_07900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NT399_07930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NT399_07945	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NT399_07950	COG0406	alpha-ribazole phosphatase activity
NT399_07965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NT399_07970	COG0730	response to heat
NT399_07990	COG4773	Receptor
NT399_07995	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NT399_08010	COG1131	(ABC) transporter
NT399_08015	COG0842	Transport permease protein
NT399_08020	COG0842	Transport permease protein
NT399_08075	COG2226	methyltransferase
NT399_08100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NT399_08105	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
NT399_08135	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NT399_08145	COG0133	tryptophan synthase activity
NT399_08160	COG3706	GGDEF domain
NT399_08175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NT399_08180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NT399_08185	COG0022	dehydrogenase e1 component
NT399_08190	COG0508	dehydrogenase complex catalyzes the overall conversion of
NT399_08195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NT399_08205	COG1063	alcohol dehydrogenase
NT399_08210	COG3781	membrane
NT399_08220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NT399_08220	COG3453	Protein conserved in bacteria
NT399_08235	COG0730	response to heat
NT399_08250	COG2207	Transcriptional regulator
NT399_08250	COG3708	Transcriptional regulator
NT399_08260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NT399_08270	COG2188	Transcriptional regulator
NT399_08285	COG4521	taurine ABC transporter
NT399_08290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NT399_08310	COG0477	Major facilitator Superfamily
NT399_08320	COG1027	Aspartate ammonia-lyase
NT399_08335	COG0583	DNA-binding transcription factor activity
NT399_08340	COG0583	DNA-binding transcription factor activity
NT399_08345	COG0183	Belongs to the thiolase family
NT399_08350	COG2031	fatty acid transporter
NT399_08365	COG0583	DNA-binding transcription factor activity
NT399_08390	COG1309	transcriptional regulator
NT399_08420	COG0543	2 iron, 2 sulfur cluster binding
NT399_08420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NT399_08425	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NT399_08430	COG4638	Rieske (2fe-2S)
NT399_08440	COG0725	ABC transporter, periplasmic molybdate-binding protein
NT399_08445	COG4149	molybdate abc transporter
NT399_08450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NT399_08455	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_08460	COG1535	isochorismatase
NT399_08460	COG3433	isochorismatase activity
NT399_08560	COG0747	negative chemotaxis
NT399_08565	COG0601	transmembrane transport
NT399_08570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NT399_08590	COG1132	(ABC) transporter
NT399_08595	COG1132	(ABC) transporter
NT399_08625	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NT399_08655	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NT399_08685	COG1902	pentaerythritol trinitrate reductase activity
NT399_08695	COG1309	transcriptional regulator
NT399_08700	COG2130	NADP-dependent
NT399_08720	COG0071	Belongs to the small heat shock protein (HSP20) family
NT399_08725	COG0542	response to heat
NT399_08765	COG3706	GGDEF domain
NT399_08795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NT399_08810	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NT399_08830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NT399_08835	COG0745	RESPONSE REGULATOR receiver
NT399_08840	COG2205	protein histidine kinase activity
NT399_08850	COG2207	Transcriptional regulator
NT399_08865	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_08935	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NT399_08990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NT399_09010	COG1120	ATPase activity
NT399_09015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NT399_09025	COG1064	alcohol dehydrogenase
NT399_09035	COG2207	Transcriptional regulator
NT399_09040	COG2084	Dehydrogenase
NT399_09050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NT399_09055	COG0583	DNA-binding transcription factor activity
NT399_09065	COG0129	dihydroxy-acid dehydratase activity
NT399_09070	COG1012	belongs to the aldehyde dehydrogenase family
NT399_09085	COG2188	Transcriptional regulator
NT399_09135	COG1473	amidohydrolase
NT399_09145	COG0475	glutathione-regulated potassium exporter activity
NT399_09145	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NT399_09155	COG0583	DNA-binding transcription factor activity
NT399_09160	COG1335	isochorismatase
NT399_09170	COG1309	transcriptional regulator
NT399_09195	COG0789	Transcriptional regulator
NT399_09210	COG1902	pentaerythritol trinitrate reductase activity
NT399_09210	COG0446	pyridine nucleotide-disulphide oxidoreductase
NT399_09225	COG1012	belongs to the aldehyde dehydrogenase family
NT399_09245	COG2186	Transcriptional regulator
NT399_09255	COG0583	DNA-binding transcription factor activity
NT399_09260	COG4948	Mandelate Racemase Muconate Lactonizing
NT399_09265	COG4829	muconolactone delta-isomerase
NT399_09275	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NT399_09280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NT399_09285	COG0183	Belongs to the thiolase family
NT399_09290	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NT399_09295	COG1012	belongs to the aldehyde dehydrogenase family
NT399_09305	COG3733	amine oxidase
NT399_09315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NT399_09325	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_09335	COG4638	Rieske (2fe-2S)
NT399_09355	COG0154	amidase activity
NT399_09365	COG2814	Major facilitator Superfamily
NT399_09390	COG1960	acyl-CoA dehydrogenase activity
NT399_09395	COG0583	DNA-binding transcription factor activity
NT399_09400	COG1414	Transcriptional regulator
NT399_09415	COG2391	methyltransferase activity
NT399_09425	COG4993	Dehydrogenase
NT399_09430	COG3659	wide pore channel activity
NT399_09435	COG3420	alginic acid biosynthetic process
NT399_09440	COG0710	3-dehydroquinate dehydratase activity
NT399_09445	COG3485	protocatechuate 3,4-dioxygenase
NT399_09450	COG3485	protocatechuate 3,4-dioxygenase
NT399_09455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NT399_09460	COG2271	Major facilitator Superfamily
NT399_09465	COG0596	Alpha beta hydrolase
NT399_09470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NT399_09475	COG0183	Belongs to the thiolase family
NT399_09480	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NT399_09485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NT399_09495	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NT399_09500	COG2323	membrane
NT399_09545	COG0446	pyridine nucleotide-disulphide oxidoreductase
NT399_09545	COG1902	pentaerythritol trinitrate reductase activity
NT399_09570	COG0542	response to heat
NT399_09575	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NT399_09605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NT399_09610	COG0569	domain protein
NT399_09615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NT399_09630	COG4774	siderophore transport
NT399_09635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NT399_09645	COG1585	Membrane protein implicated in regulation of membrane protease activity
NT399_09660	COG1294	oxidase, subunit
NT399_09665	COG4890	Cyd operon protein YbgT
NT399_09675	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NT399_09685	COG0552	protein localization to endoplasmic reticulum
NT399_09710	COG0517	IMP dehydrogenase activity
NT399_09710	COG0516	GMP reductase activity
NT399_09715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NT399_09720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NT399_09730	COG0583	DNA-binding transcription factor activity
NT399_09735	COG0024	Methionine aminopeptidase
NT399_09765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NT399_09765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NT399_09770	COG1105	Belongs to the carbohydrate kinase PfkB family
NT399_09775	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NT399_09775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NT399_09775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NT399_09805	COG1011	Hydrolase
NT399_09810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NT399_09820	COG2137	regulation of response to DNA damage stimulus
NT399_09835	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NT399_09870	COG0575	Belongs to the CDS family
NT399_09875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NT399_09900	COG3852	Histidine kinase
NT399_09905	COG2204	response regulator
NT399_09970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NT399_09975	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NT399_09995	COG0697	spore germination
NT399_10015	COG0303	'Molybdopterin
NT399_10020	COG0315	cyclic pyranopterin monophosphate synthase activity
NT399_10020	COG0521	Mo-molybdopterin cofactor biosynthetic process
NT399_10035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NT399_10040	COG0243	molybdopterin cofactor binding
NT399_10050	COG0243	molybdopterin cofactor binding
NT399_10055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NT399_10060	COG2146	nitrite reductase [NAD(P)H] activity
NT399_10060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NT399_10070	COG0745	RESPONSE REGULATOR receiver
NT399_10075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NT399_10075	COG1116	anion transmembrane transporter activity
NT399_10090	COG0511	ligase activity, forming carbon-carbon bonds
NT399_10105	COG2814	Major facilitator Superfamily
NT399_10150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NT399_10230	COG3566	protein conserved in bacteria
NT399_10245	COG3567	Phage-associated protein, HI1409 family
NT399_10250	COG5410	chromosome segregation
NT399_10445	COG0069	glutamate synthase activity
NT399_10465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NT399_10475	COG1454	alcohol dehydrogenase
NT399_10480	COG0824	Thioesterase
NT399_10490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NT399_10505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NT399_10510	COG2030	dehydratase
NT399_10520	COG0183	Belongs to the thiolase family
NT399_10530	COG0583	DNA-binding transcription factor activity
NT399_10535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NT399_10545	COG1522	sequence-specific DNA binding
NT399_10550	COG3135	benzoate transporter
NT399_10575	COG0589	response to stress
NT399_10580	COG0488	(ABC) transporter
NT399_10600	COG4773	Receptor
NT399_10630	COG0668	transmembrane transport
NT399_10650	COG3971	2-oxopent-4-enoate hydratase activity
NT399_10660	COG2271	Major facilitator Superfamily
NT399_10690	COG1605	Chorismate mutase
NT399_10710	COG0308	aminopeptidase N
NT399_10740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NT399_10745	COG1454	alcohol dehydrogenase
NT399_10765	COG0531	amino acid
NT399_10770	COG4303	Ethanolamine ammonia lyase large subunit
NT399_10775	COG4302	ethanolamine ammonia-lyase activity
NT399_10780	COG0519	Catalyzes the synthesis of GMP from XMP
NT399_10780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NT399_10785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NT399_10810	COG0697	spore germination
NT399_10815	COG1923	regulation of RNA biosynthetic process
NT399_10825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NT399_10830	COG0802	atpase or kinase
NT399_10850	COG1187	pseudouridine synthase activity
NT399_10865	COG0583	DNA-binding transcription factor activity
NT399_10880	COG2814	Major facilitator Superfamily
NT399_10885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NT399_10910	COG0729	surface antigen
NT399_10930	COG0174	glutamine synthetase
NT399_10935	COG0745	RESPONSE REGULATOR receiver
NT399_10940	COG2205	protein histidine kinase activity
NT399_10950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NT399_10955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NT399_10980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NT399_10985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NT399_10990	COG1960	acyl-CoA dehydrogenase activity
NT399_11025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NT399_11035	COG3658	cytochrome
NT399_11040	COG1215	transferase activity, transferring glycosyl groups
NT399_11045	COG0726	polysaccharide deacetylase
NT399_11045	COG1649	PFAM Uncharacterised BCR, COG1649
NT399_11075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NT399_11080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NT399_11090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NT399_11115	COG0305	Participates in initiation and elongation during chromosome replication
NT399_11120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NT399_11130	COG1305	Transglutaminase-like
NT399_11170	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NT399_11175	COG0138	bifunctional purine biosynthesis protein purh
NT399_11180	COG0151	Belongs to the GarS family
NT399_11185	COG1464	Belongs to the NlpA lipoprotein family
NT399_11190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NT399_11195	COG2011	ABC-type metal ion transport system permease component
NT399_11200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NT399_11210	COG1301	dicarboxylic acid transport
NT399_11240	COG1794	racemase activity, acting on amino acids and derivatives
NT399_11245	COG3118	belongs to the thioredoxin family
NT399_11245	COG0492	ferredoxin-NADP+ reductase activity
NT399_11260	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NT399_11260	COG3008	intermembrane lipid transfer
NT399_11265	COG2995	paraquat-inducible protein a
NT399_11295	COG0477	Major facilitator Superfamily
NT399_11350	COG2186	Transcriptional regulator
NT399_11360	COG0786	glutamate:sodium symporter activity
NT399_11365	COG3243	poly(R)-hydroxyalkanoic acid synthase
NT399_11390	COG3111	PFAM Bacterial OB fold (BOF) protein
NT399_11430	COG2801	Transposase and inactivated derivatives
NT399_11470	COG2831	hemolysin activation secretion protein
NT399_11495	COG0515	serine threonine protein kinase
NT399_11495	COG2815	serine threonine protein kinase
NT399_11525	COG1610	YqeY-like protein
NT399_11530	COG4783	chaperone-mediated protein folding
NT399_11555	COG1286	toxin biosynthetic process
NT399_11585	COG0778	Nitroreductase
NT399_11595	COG0513	Belongs to the DEAD box helicase family
NT399_11620	COG2363	Small membrane protein
NT399_11665	COG2195	Cleaves the N-terminal amino acid of tripeptides
NT399_11675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NT399_11685	COG2819	hydrolase of the alpha beta superfamily
NT399_11690	COG1960	acyl-CoA dehydrogenase activity
NT399_11695	COG1301	dicarboxylic acid transport
NT399_11700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NT399_11705	COG3139	Protein of unknown function (DUF1315)
NT399_11710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NT399_11715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NT399_11725	COG0494	nUDIX hydrolase
NT399_11735	COG0642	Histidine kinase
NT399_11750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NT399_11760	COG1720	tRNA m6t6A37 methyltransferase activity
NT399_11775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NT399_11780	COG0826	peptidase U32
NT399_11785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NT399_11795	COG4598	ABC transporter
NT399_11800	COG4160	amino acid transport
NT399_11805	COG4215	(ABC) transporter
NT399_11820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NT399_11865	COG1131	(ABC) transporter
NT399_11870	COG0842	Transport permease protein
NT399_11885	COG0772	Belongs to the SEDS family
NT399_11890	COG2951	lytic endotransglycosylase activity
NT399_11915	COG2207	Transcriptional regulator
NT399_11930	COG0052	Belongs to the universal ribosomal protein uS2 family
NT399_11935	COG0024	Methionine aminopeptidase
NT399_11945	COG2223	nitrite transmembrane transporter activity
NT399_11955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NT399_11960	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NT399_11965	COG1960	acyl-CoA dehydrogenase activity
NT399_11980	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NT399_11985	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NT399_11990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NT399_12010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NT399_12015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NT399_12020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NT399_12060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NT399_12070	COG0174	glutamine synthetase
NT399_12090	COG0512	Glutamine amidotransferase of anthranilate synthase
NT399_12095	COG0308	aminopeptidase N
NT399_12125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NT399_12135	COG0302	gtp cyclohydrolase
NT399_12155	COG3739	integral membrane protein
NT399_12180	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NT399_12185	COG1132	(ABC) transporter
NT399_12190	COG1132	(ABC) transporter
NT399_12205	COG1535	isochorismatase
NT399_12205	COG3433	isochorismatase activity
NT399_12210	COG1021	2,3-dihydroxybenzoate-AMP ligase
NT399_12215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NT399_12225	COG4774	siderophore transport
NT399_12230	COG4607	ABC-type enterochelin transport system periplasmic component
NT399_12235	COG4604	ABC transporter, ATP-binding protein
NT399_12240	COG4605	iron ion homeostasis
NT399_12245	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NT399_12250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NT399_12265	COG2964	Protein conserved in bacteria
NT399_12275	COG1741	Belongs to the pirin family
NT399_12295	COG4214	carbohydrate transport
NT399_12310	COG2879	small protein
NT399_12315	COG1966	Carbon starvation protein
NT399_12335	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NT399_12360	COG1067	ATP-dependent peptidase activity
NT399_12365	COG0583	DNA-binding transcription factor activity
NT399_12390	COG1686	Belongs to the peptidase S11 family
NT399_12395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NT399_12430	COG0616	signal peptide processing
NT399_12435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NT399_12445	COG0573	inorganic phosphate transmembrane transporter activity
NT399_12450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NT399_12455	COG1113	amino acid transport
NT399_12460	COG3961	Belongs to the TPP enzyme family
NT399_12465	COG1522	sequence-specific DNA binding
NT399_12475	COG0076	glutamate decarboxylase activity
NT399_12480	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NT399_12490	COG1309	transcriptional regulator
NT399_12505	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NT399_12540	COG0352	thiamine-phosphate diphosphorylase activity
NT399_12565	COG1203	CRISPR-associated helicase, Cas3
NT399_12600	COG0612	Peptidase, M16
NT399_12610	COG1823	symporter activity
NT399_12615	COG0583	DNA-binding transcription factor activity
NT399_12620	COG0477	Major facilitator Superfamily
NT399_12645	COG1187	pseudouridine synthase activity
NT399_12660	COG1686	Belongs to the peptidase S11 family
NT399_12665	COG1252	NADH dehydrogenase
NT399_12675	COG0415	Belongs to the DNA photolyase family
NT399_12695	COG1215	transferase activity, transferring glycosyl groups
NT399_12725	COG2070	2-Nitropropane dioxygenase
NT399_12780	COG0556	nucleotide-excision repair
NT399_12800	COG0436	Aminotransferase
NT399_12815	COG0443	Heat shock 70 kDa protein
NT399_12865	COG4221	oxidoreductase activity
NT399_12875	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NT399_12880	COG1381	Involved in DNA repair and RecF pathway recombination
NT399_12890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NT399_12905	COG0681	Belongs to the peptidase S26 family
NT399_12915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NT399_12925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NT399_12945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NT399_12950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NT399_12955	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NT399_12965	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NT399_12970	COG4208	sulfate ABC transporter
NT399_12975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NT399_12980	COG0583	DNA-binding transcription factor activity
NT399_12985	COG4625	pathogenesis
NT399_13000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NT399_13015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NT399_13025	COG1051	belongs to the nudix hydrolase family
NT399_13025	COG1056	cytidyltransferase-related domain
NT399_13030	COG1024	Enoyl-CoA hydratase
NT399_13045	COG2814	Major facilitator Superfamily
NT399_13050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NT399_13050	COG0047	phosphoribosylformylglycinamidine synthase activity
NT399_13075	COG0824	Thioesterase
NT399_13095	COG0823	Involved in the tonB-independent uptake of proteins
NT399_13115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NT399_13170	COG0628	permease
NT399_13180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NT399_13185	COG0596	Alpha beta hydrolase
NT399_13190	COG0616	signal peptide processing
NT399_13190	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NT399_13200	COG0658	competence protein
NT399_13200	COG2333	competence protein COMEC
NT399_13205	COG1136	(ABC) transporter
NT399_13210	COG4591	ABC-type transport system involved in lipoprotein release permease component
NT399_13240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NT399_13260	COG0463	Glycosyl transferase, family 2
NT399_13290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NT399_13295	COG1280	lysine exporter protein (LysE YggA)
NT399_13305	COG0019	diaminopimelate decarboxylase activity
NT399_13315	COG1113	amino acid transport
NT399_13330	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NT399_13340	COG3339	Conserved Protein
NT399_13345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NT399_13350	COG0243	molybdopterin cofactor binding
NT399_13355	COG1929	Belongs to the glycerate kinase type-1 family
NT399_13370	COG0778	Nitroreductase
NT399_13400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NT399_13405	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NT399_13420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NT399_13440	COG0741	lytic transglycosylase activity
NT399_13460	COG0584	glycerophosphoryl diester phosphodiesterase
NT399_13465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NT399_13485	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NT399_13490	COG1597	lipid kinase activity
NT399_13505	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NT399_13510	COG0477	Major facilitator Superfamily
NT399_13560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NT399_13565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NT399_13590	COG0505	Belongs to the CarA family
NT399_13610	COG0251	oxidation-reduction process
NT399_13620	COG0589	response to stress
NT399_13660	COG2321	neutral zinc metallopeptidase
NT399_13665	COG2354	Protein conserved in bacteria
NT399_13685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NT399_13710	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NT399_13715	COG1053	succinate dehydrogenase
NT399_13720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NT399_13725	COG2009	succinate dehydrogenase
NT399_13760	COG2921	Belongs to the UPF0250 family
NT399_13765	COG0321	lipoyl(octanoyl) transferase activity
NT399_13780	COG0531	amino acid
NT399_13790	COG1733	regulation of RNA biosynthetic process
NT399_13795	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NT399_13800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NT399_13800	COG1648	precorrin-2 dehydrogenase activity
NT399_13815	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NT399_13845	COG0671	phosphoesterase, PA-phosphatase related
NT399_13850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NT399_13860	COG1538	Outer membrane efflux protein
NT399_13865	COG0393	Putative heavy-metal-binding
NT399_13870	COG0393	Putative heavy-metal-binding
NT399_13880	COG1028	Short-chain dehydrogenase reductase Sdr
NT399_13890	COG0525	valine-tRNA ligase activity
NT399_13915	COG0583	DNA-binding transcription factor activity
NT399_13920	COG0004	ammonium transporteR
NT399_13930	COG0642	Histidine kinase
NT399_13935	COG0745	RESPONSE REGULATOR receiver
NT399_13940	COG2194	sulfuric ester hydrolase activity
NT399_13960	COG1752	Esterase of the alpha-beta hydrolase superfamily
NT399_13980	COG0142	geranyltranstransferase activity
NT399_13985	COG2828	Protein conserved in bacteria
NT399_13990	COG1113	amino acid transport
NT399_14000	COG0582	viral genome integration into host DNA
NT399_14085	COG2207	Transcriptional regulator
NT399_14110	COG2249	NAD(P)H dehydrogenase (quinone) activity
NT399_14120	COG0560	Phosphoserine phosphatase
NT399_14130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NT399_14140	COG1530	ribonuclease E activity
NT399_14145	COG0424	maF-like protein
NT399_14150	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NT399_14155	COG1792	Involved in formation and maintenance of cell shape
NT399_14160	COG1077	Cell shape determining protein MreB Mrl
NT399_14165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NT399_14175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NT399_14205	COG3590	peptidase
NT399_14210	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
NT399_14215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NT399_14220	COG1752	Esterase of the alpha-beta hydrolase superfamily
NT399_14225	COG1115	amino acid carrier protein
NT399_14250	COG1289	transmembrane transporter activity
NT399_14260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NT399_14300	COG1376	ErfK ybiS ycfS ynhG family protein
NT399_14305	COG2832	Protein of unknown function (DUF454)
NT399_14315	COG5510	response to toxic substance
NT399_14335	COG0840	transmembrane signaling receptor activity
NT399_14375	COG3422	double-strand break repair
NT399_14380	COG2824	Alkylphosphonate utilization operon protein PhnA
NT399_14385	COG3189	MarR family transcriptional regulator
NT399_14395	COG0354	folic acid binding
NT399_14400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NT399_14415	COG1902	pentaerythritol trinitrate reductase activity
NT399_14420	COG4772	TonB-dependent receptor
NT399_14425	COG2094	Belongs to the DNA glycosylase MPG family
NT399_14450	COG1217	gtp-binding protein TYPA
NT399_14455	COG2233	PERMEase
NT399_14465	COG0833	amino acid
NT399_14470	COG1690	Belongs to the RtcB family
NT399_14480	COG2885	chlorophyll binding
NT399_14480	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NT399_14490	COG0183	Belongs to the thiolase family
NT399_14510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NT399_14530	COG2207	Transcriptional regulator
NT399_14535	COG0183	Belongs to the thiolase family
NT399_14565	COG1272	protein, Hemolysin III
NT399_14585	COG0450	alkyl hydroperoxide reductase
NT399_14605	COG0285	dihydrofolate synthase activity
NT399_14655	COG2096	Adenosyltransferase
NT399_14660	COG0584	glycerophosphoryl diester phosphodiesterase
NT399_14675	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NT399_14680	COG0745	RESPONSE REGULATOR receiver
NT399_14685	COG2205	protein histidine kinase activity
NT399_14695	COG1960	acyl-CoA dehydrogenase activity
NT399_14700	COG1960	acyl-CoA dehydrogenase activity
NT399_14750	COG1442	glycosyl transferase family 8
NT399_14755	COG0438	transferase activity, transferring glycosyl groups
NT399_14760	COG0438	transferase activity, transferring glycosyl groups
NT399_14770	COG0438	transferase activity, transferring glycosyl groups
NT399_14775	COG0726	polysaccharide deacetylase
NT399_14790	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NT399_14795	COG2205	protein histidine kinase activity
NT399_14830	COG1862	Preprotein translocase
NT399_14840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NT399_14845	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NT399_14855	COG3781	membrane
NT399_14860	COG0613	PHP domain protein
NT399_14870	COG2350	Protein conserved in bacteria
NT399_14900	COG1607	acyl-coa hydrolase
NT399_14965	COG2199	diguanylate cyclase activity
NT399_14975	COG1408	metallophosphoesterase
NT399_14980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NT399_14990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NT399_15010	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NT399_15015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NT399_15030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NT399_15040	COG2969	positive regulation of protein catabolic process
NT399_15080	COG1309	transcriptional regulator
NT399_15085	COG1960	acyl-CoA dehydrogenase activity
NT399_15130	COG1183	phosphatidylcholine synthase activity
NT399_15135	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NT399_15165	COG0741	lytic transglycosylase activity
NT399_15165	COG0739	heme binding
NT399_15165	COG1196	nuclear chromosome segregation
NT399_15175	COG1702	phosphate starvation-inducible protein PhoH
NT399_15210	COG1295	ribonuclease BN
NT399_15215	COG0697	spore germination
NT399_15220	COG2169	Transcriptional regulator
NT399_15225	COG0179	Fumarylacetoacetate (FAA) hydrolase
NT399_15270	COG0557	exoribonuclease II activity
NT399_15275	COG0339	signal peptide processing
NT399_15280	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NT399_15310	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NT399_15315	COG1960	acyl-CoA dehydrogenase activity
NT399_15470	COG0626	cystathionine gamma-synthase activity
NT399_15475	COG0433	COG0433 Predicted ATPase
NT399_15485	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NT399_15485	COG1017	nitric oxide dioxygenase activity
NT399_15490	COG1959	2 iron, 2 sulfur cluster binding
NT399_15505	COG1301	dicarboxylic acid transport
NT399_15510	COG1946	Acyl-CoA thioesterase
NT399_15530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NT399_15535	COG1040	competence protein
NT399_15540	COG0494	nUDIX hydrolase
NT399_15550	COG0598	Magnesium transport protein CorA
NT399_15560	COG2854	intermembrane phospholipid transfer
NT399_15570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NT399_15575	COG1127	ABC transporter
NT399_15585	COG0513	Belongs to the DEAD box helicase family
NT399_15605	COG0408	coproporphyrinogen oxidase activity
NT399_15620	COG1960	acyl-CoA dehydrogenase activity
NT399_15630	COG1983	PspC domain protein
NT399_15635	COG0517	IMP dehydrogenase activity
NT399_15680	COG0583	DNA-binding transcription factor activity
NT399_15720	COG1012	belongs to the aldehyde dehydrogenase family
NT399_15730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NT399_15735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NT399_15740	COG0833	amino acid
NT399_15770	COG1192	Involved in chromosome partitioning
NT399_15775	COG0628	permease
NT399_15785	COG1289	transmembrane transporter activity
NT399_15800	COG2249	NAD(P)H dehydrogenase (quinone) activity
NT399_15805	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NT399_15815	COG0277	FAD linked oxidase domain protein
NT399_15820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NT399_15845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NT399_15850	COG5380	lipid catabolic process
NT399_15870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NT399_15920	COG0194	GDP metabolic process
NT399_15935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NT399_15955	COG3307	-O-antigen
NT399_15975	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NT399_15980	COG1704	LemA family
NT399_15990	COG0493	'glutamate synthase
NT399_15995	COG0070	glutamate synthase
NT399_15995	COG0069	glutamate synthase activity
NT399_15995	COG0067	glutamate synthase
NT399_16045	COG2226	methyltransferase
NT399_16060	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NT399_16065	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NT399_16110	COG0833	amino acid
NT399_16195	COG0488	(ABC) transporter
NT399_16200	COG2873	o-acetylhomoserine
NT399_16205	COG4221	oxidoreductase activity
NT399_16210	COG0659	secondary active sulfate transmembrane transporter activity
NT399_16235	COG0427	acetyl-CoA hydrolase
NT399_16265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NT399_16305	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NT399_16460	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NT399_16485	COG1335	isochorismatase
NT399_16495	COG1012	belongs to the aldehyde dehydrogenase family
NT399_16500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NT399_16510	COG1113	amino acid transport
NT399_16520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NT399_16535	COG2814	Major facilitator Superfamily
NT399_16545	COG0352	thiamine-phosphate diphosphorylase activity
NT399_16545	COG0351	phosphomethylpyrimidine kinase
NT399_16545	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NT399_16565	COG1309	transcriptional regulator
NT399_16570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NT399_16580	COG3293	Transposase
NT399_16590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NT399_16600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NT399_16605	COG3162	membrane
NT399_16610	COG0784	Response regulator, receiver
NT399_16610	COG2198	Histidine kinase
NT399_16610	COG2205	protein histidine kinase activity
NT399_16640	COG1335	isochorismatase
NT399_16645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NT399_16655	COG0668	transmembrane transport
NT399_16660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NT399_16665	COG1519	Transferase
NT399_16670	COG1902	pentaerythritol trinitrate reductase activity
NT399_16690	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NT399_16715	COG0426	domain, Protein
NT399_16715	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NT399_16720	COG4774	siderophore transport
NT399_16725	COG2119	membrane
NT399_16735	COG0508	dehydrogenase complex catalyzes the overall conversion of
NT399_16745	COG4942	peptidase
NT399_16760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NT399_16770	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NT399_16790	COG0189	ligase activity
NT399_16810	COG0708	Exodeoxyribonuclease III
NT399_16815	COG1393	Belongs to the ArsC family
NT399_16880	COG2351	hydroxyisourate hydrolase activity
NT399_16885	COG2233	PERMEase
NT399_16895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NT399_16905	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
NT399_16915	COG3150	esterase
NT399_16935	COG2918	glutathione biosynthetic process
NT399_16950	COG2733	membrane
NT399_16955	COG0436	Aminotransferase
NT399_16960	COG0534	Mate efflux family protein
NT399_17045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NT399_17050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NT399_17060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NT399_17090	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NT399_17110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NT399_17145	COG0010	Belongs to the arginase family
NT399_17175	COG2188	Transcriptional regulator
NT399_17185	COG0523	cobalamin synthesis protein
NT399_17195	COG1113	amino acid transport
NT399_17205	COG0625	glutathione transferase activity
NT399_17225	COG1683	Conserved Protein
NT399_17230	COG0534	Mate efflux family protein
NT399_17235	COG0385	Bile acid
NT399_17240	COG1335	isochorismatase
NT399_17245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NT399_17265	COG2116	formate transmembrane transporter activity
NT399_17270	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NT399_17275	COG2133	pyrroloquinoline quinone binding
NT399_17280	COG2983	Belongs to the UPF0260 family
NT399_17300	COG1194	a g-specific adenine glycosylase
NT399_17315	COG2818	Glycosylase
NT399_17320	COG1064	alcohol dehydrogenase
NT399_17325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NT399_17340	COG0583	DNA-binding transcription factor activity
NT399_17350	COG2814	Major facilitator Superfamily
NT399_17385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NT399_17400	COG2233	PERMEase
NT399_17405	COG0583	DNA-binding transcription factor activity
NT399_17430	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NT399_17440	COG0733	neurotransmitter:sodium symporter activity
NT399_17480	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NT399_17485	COG0657	acetylesterase activity
NT399_17505	COG0583	DNA-binding transcription factor activity
NT399_17535	COG2951	lytic endotransglycosylase activity
NT399_17540	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NT399_17555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NT399_17565	COG0671	phosphoesterase, PA-phosphatase related
NT399_17570	COG0861	Integral membrane protein TerC family
NT399_17580	COG0754	glutathionylspermidine amidase activity
NT399_17590	COG0402	S-adenosylhomocysteine deaminase activity
NT399_17605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NT399_17610	COG1230	cation diffusion facilitator family transporter
NT399_17625	COG0706	membrane insertase activity
NT399_17695	COG1373	ATPase (AAA superfamily
NT399_17705	COG0446	pyridine nucleotide-disulphide oxidoreductase
NT399_17705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NT399_17720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NT399_17745	COG0347	Belongs to the P(II) protein family
NT399_17760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NT399_17780	COG2197	response regulator
NT399_17785	COG3850	Histidine kinase
NT399_17790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NT399_17795	COG1475	DNA binding
NT399_17800	COG1192	Involved in chromosome partitioning
NT399_17815	COG3604	Transcriptional regulator
NT399_17840	COG2144	transferase activity, transferring acyl groups
NT399_17850	COG2072	flavoprotein involved in K transport
NT399_17865	COG2815	serine threonine protein kinase
NT399_17865	COG0515	serine threonine protein kinase
NT399_17900	COG0582	viral genome integration into host DNA
NT399_17920	COG0069	glutamate synthase activity
NT399_17925	COG2218	PFAM glutamate synthase alpha subunit domain protein
NT399_17930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NT399_17940	COG1396	sequence-specific DNA binding
NT399_17945	COG0004	ammonium transporteR
NT399_17950	COG0004	ammonium transporteR
NT399_18085	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NT399_18105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NT399_18125	COG0477	Major facilitator Superfamily
NT399_18130	COG0697	spore germination
NT399_18140	COG3328	transposase activity
NT399_18165	COG3121	Chaperone
NT399_18170	COG3188	usher protein
NT399_18180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NT399_18275	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
NT399_18300	COG0753	catalase activity