locus-tag	class	description
L2Z06_00040	COG0739	heme binding
L2Z06_00165	COG5410	chromosome segregation
L2Z06_00330	COG0069	glutamate synthase activity
L2Z06_00350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z06_00360	COG1454	alcohol dehydrogenase
L2Z06_00365	COG0824	Thioesterase
L2Z06_00375	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z06_00390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z06_00395	COG2030	dehydratase
L2Z06_00405	COG0183	Belongs to the thiolase family
L2Z06_00415	COG0583	DNA-binding transcription factor activity
L2Z06_00420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z06_00430	COG1522	sequence-specific DNA binding
L2Z06_00435	COG3135	benzoate transporter
L2Z06_00445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z06_00470	COG0589	response to stress
L2Z06_00475	COG0488	(ABC) transporter
L2Z06_00495	COG4773	Receptor
L2Z06_00530	COG0668	transmembrane transport
L2Z06_00540	COG1309	transcriptional regulator
L2Z06_00560	COG1605	Chorismate mutase
L2Z06_00590	COG0308	aminopeptidase N
L2Z06_00610	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z06_00620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z06_00625	COG1454	alcohol dehydrogenase
L2Z06_00645	COG0531	amino acid
L2Z06_00650	COG4303	Ethanolamine ammonia lyase large subunit
L2Z06_00655	COG4302	ethanolamine ammonia-lyase activity
L2Z06_00660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z06_00660	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z06_00665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z06_00675	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z06_00690	COG0697	spore germination
L2Z06_00695	COG1923	regulation of RNA biosynthetic process
L2Z06_00705	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z06_00710	COG0802	atpase or kinase
L2Z06_00730	COG1187	pseudouridine synthase activity
L2Z06_00745	COG0583	DNA-binding transcription factor activity
L2Z06_00760	COG2814	Major facilitator Superfamily
L2Z06_00765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z06_00790	COG0729	surface antigen
L2Z06_00810	COG0174	glutamine synthetase
L2Z06_00815	COG0745	RESPONSE REGULATOR receiver
L2Z06_00820	COG2205	protein histidine kinase activity
L2Z06_00830	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z06_00835	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z06_00860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z06_00865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z06_00870	COG1960	acyl-CoA dehydrogenase activity
L2Z06_00885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z06_00890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z06_00910	COG0583	DNA-binding transcription factor activity
L2Z06_00925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z06_00935	COG3658	cytochrome
L2Z06_00940	COG1215	transferase activity, transferring glycosyl groups
L2Z06_00945	COG0726	polysaccharide deacetylase
L2Z06_00945	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z06_00970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z06_00975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z06_00985	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z06_01010	COG0305	Participates in initiation and elongation during chromosome replication
L2Z06_01015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z06_01025	COG1305	Transglutaminase-like
L2Z06_01035	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z06_01065	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z06_01070	COG0138	bifunctional purine biosynthesis protein purh
L2Z06_01075	COG0151	Belongs to the GarS family
L2Z06_01080	COG1464	Belongs to the NlpA lipoprotein family
L2Z06_01085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z06_01090	COG2011	ABC-type metal ion transport system permease component
L2Z06_01095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z06_01105	COG1301	dicarboxylic acid transport
L2Z06_01145	COG2433	Pfam Transposase IS66
L2Z06_01155	COG3173	Aminoglycoside phosphotransferase
L2Z06_01160	COG0488	(ABC) transporter
L2Z06_01190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z06_01190	COG3008	intermembrane lipid transfer
L2Z06_01195	COG2995	paraquat-inducible protein a
L2Z06_01205	COG2985	domain, Protein
L2Z06_01235	COG0477	Major facilitator Superfamily
L2Z06_01285	COG2186	Transcriptional regulator
L2Z06_01295	COG0786	glutamate:sodium symporter activity
L2Z06_01300	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z06_01325	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z06_01425	COG1610	YqeY-like protein
L2Z06_01430	COG4783	chaperone-mediated protein folding
L2Z06_01455	COG1286	toxin biosynthetic process
L2Z06_01485	COG0778	Nitroreductase
L2Z06_01495	COG0513	Belongs to the DEAD box helicase family
L2Z06_01520	COG2363	Small membrane protein
L2Z06_01550	COG1234	tRNA 3'-trailer cleavage
L2Z06_01555	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z06_01565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z06_01575	COG2819	hydrolase of the alpha beta superfamily
L2Z06_01580	COG1960	acyl-CoA dehydrogenase activity
L2Z06_01585	COG1301	dicarboxylic acid transport
L2Z06_01590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z06_01595	COG3139	Protein of unknown function (DUF1315)
L2Z06_01600	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z06_01605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z06_01615	COG0494	nUDIX hydrolase
L2Z06_01625	COG0642	Histidine kinase
L2Z06_01640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z06_01650	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z06_01665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z06_01670	COG0826	peptidase U32
L2Z06_01675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z06_01685	COG4598	ABC transporter
L2Z06_01690	COG4160	amino acid transport
L2Z06_01695	COG4215	(ABC) transporter
L2Z06_01710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z06_01755	COG1131	(ABC) transporter
L2Z06_01760	COG0842	Transport permease protein
L2Z06_01775	COG0772	Belongs to the SEDS family
L2Z06_01780	COG2951	lytic endotransglycosylase activity
L2Z06_01805	COG2207	Transcriptional regulator
L2Z06_01820	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z06_01825	COG0024	Methionine aminopeptidase
L2Z06_01835	COG2223	nitrite transmembrane transporter activity
L2Z06_01845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z06_01850	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z06_01855	COG1960	acyl-CoA dehydrogenase activity
L2Z06_01870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z06_01875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z06_01880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z06_01900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z06_01905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z06_01910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z06_01935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z06_01945	COG0174	glutamine synthetase
L2Z06_01960	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z06_01965	COG0308	aminopeptidase N
L2Z06_01995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z06_02005	COG0302	gtp cyclohydrolase
L2Z06_02030	COG3739	integral membrane protein
L2Z06_02045	COG1169	isochorismate synthase
L2Z06_02055	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z06_02060	COG1132	(ABC) transporter
L2Z06_02065	COG1132	(ABC) transporter
L2Z06_02080	COG3433	isochorismatase activity
L2Z06_02080	COG1535	isochorismatase
L2Z06_02085	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z06_02090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z06_02100	COG4774	siderophore transport
L2Z06_02105	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z06_02110	COG4604	ABC transporter, ATP-binding protein
L2Z06_02115	COG4605	iron ion homeostasis
L2Z06_02120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z06_02125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z06_02140	COG2964	Protein conserved in bacteria
L2Z06_02150	COG1741	Belongs to the pirin family
L2Z06_02170	COG1309	transcriptional regulator
L2Z06_02180	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z06_02185	COG2814	Major facilitator Superfamily
L2Z06_02220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z06_02220	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z06_02225	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z06_02235	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_02245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z06_02250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z06_02255	COG0583	DNA-binding transcription factor activity
L2Z06_02260	COG1113	amino acid transport
L2Z06_02280	COG2508	Transcriptional regulator
L2Z06_02280	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z06_02315	COG2879	small protein
L2Z06_02320	COG1966	Carbon starvation protein
L2Z06_02365	COG1067	ATP-dependent peptidase activity
L2Z06_02370	COG0583	DNA-binding transcription factor activity
L2Z06_02395	COG1686	Belongs to the peptidase S11 family
L2Z06_02400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z06_02430	COG3328	transposase activity
L2Z06_02440	COG0616	signal peptide processing
L2Z06_02445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z06_02455	COG0573	inorganic phosphate transmembrane transporter activity
L2Z06_02460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z06_02465	COG1113	amino acid transport
L2Z06_02470	COG3961	Belongs to the TPP enzyme family
L2Z06_02475	COG1522	sequence-specific DNA binding
L2Z06_02485	COG0076	glutamate decarboxylase activity
L2Z06_02490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z06_02500	COG1309	transcriptional regulator
L2Z06_02515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z06_02550	COG0352	thiamine-phosphate diphosphorylase activity
L2Z06_02575	COG0612	Peptidase, M16
L2Z06_02595	COG1823	symporter activity
L2Z06_02600	COG0583	DNA-binding transcription factor activity
L2Z06_02605	COG0477	Major facilitator Superfamily
L2Z06_02630	COG1187	pseudouridine synthase activity
L2Z06_02645	COG1686	Belongs to the peptidase S11 family
L2Z06_02650	COG1252	NADH dehydrogenase
L2Z06_02660	COG0415	Belongs to the DNA photolyase family
L2Z06_02675	COG1215	transferase activity, transferring glycosyl groups
L2Z06_02705	COG2070	2-Nitropropane dioxygenase
L2Z06_02760	COG0556	nucleotide-excision repair
L2Z06_02780	COG0436	Aminotransferase
L2Z06_02810	COG4221	oxidoreductase activity
L2Z06_02820	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z06_02825	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z06_02835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z06_02850	COG0681	Belongs to the peptidase S26 family
L2Z06_02865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z06_02885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z06_02890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z06_02895	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z06_02905	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z06_02910	COG4208	sulfate ABC transporter
L2Z06_02915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z06_02920	COG0583	DNA-binding transcription factor activity
L2Z06_02925	COG4625	pathogenesis
L2Z06_02940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z06_02955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z06_02965	COG1051	belongs to the nudix hydrolase family
L2Z06_02965	COG1056	cytidyltransferase-related domain
L2Z06_02970	COG1024	Enoyl-CoA hydratase
L2Z06_02980	COG2814	Major facilitator Superfamily
L2Z06_02985	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z06_02985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z06_03005	COG1473	amidohydrolase
L2Z06_03010	COG0824	Thioesterase
L2Z06_03030	COG0823	Involved in the tonB-independent uptake of proteins
L2Z06_03050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z06_03085	COG0628	permease
L2Z06_03095	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z06_03100	COG0596	Alpha beta hydrolase
L2Z06_03105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z06_03105	COG0616	signal peptide processing
L2Z06_03115	COG2333	competence protein COMEC
L2Z06_03115	COG0658	competence protein
L2Z06_03120	COG1136	(ABC) transporter
L2Z06_03125	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z06_03160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z06_03180	COG0463	Glycosyl transferase, family 2
L2Z06_03210	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z06_03215	COG1280	lysine exporter protein (LysE YggA)
L2Z06_03225	COG0019	diaminopimelate decarboxylase activity
L2Z06_03235	COG1113	amino acid transport
L2Z06_03250	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z06_03260	COG3339	Conserved Protein
L2Z06_03265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z06_03270	COG0243	molybdopterin cofactor binding
L2Z06_03275	COG1929	Belongs to the glycerate kinase type-1 family
L2Z06_03290	COG0778	Nitroreductase
L2Z06_03320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z06_03335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z06_03355	COG0741	lytic transglycosylase activity
L2Z06_03375	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z06_03405	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z06_03410	COG1597	lipid kinase activity
L2Z06_03425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z06_03430	COG0477	Major facilitator Superfamily
L2Z06_03480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z06_03485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z06_03510	COG0505	Belongs to the CarA family
L2Z06_03530	COG0589	response to stress
L2Z06_03545	COG2843	Capsule synthesis protein
L2Z06_03565	COG2321	neutral zinc metallopeptidase
L2Z06_03570	COG2354	Protein conserved in bacteria
L2Z06_03590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z06_03615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z06_03620	COG1053	succinate dehydrogenase
L2Z06_03625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z06_03630	COG2009	succinate dehydrogenase
L2Z06_03670	COG2921	Belongs to the UPF0250 family
L2Z06_03675	COG0321	lipoyl(octanoyl) transferase activity
L2Z06_03690	COG0531	amino acid
L2Z06_03700	COG1733	regulation of RNA biosynthetic process
L2Z06_03705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z06_03710	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z06_03710	COG1648	precorrin-2 dehydrogenase activity
L2Z06_03725	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z06_03755	COG0671	phosphoesterase, PA-phosphatase related
L2Z06_03760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z06_03770	COG1538	Outer membrane efflux protein
L2Z06_03775	COG0393	Putative heavy-metal-binding
L2Z06_03780	COG0393	Putative heavy-metal-binding
L2Z06_03790	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_03800	COG0525	valine-tRNA ligase activity
L2Z06_03820	COG0583	DNA-binding transcription factor activity
L2Z06_03825	COG0004	ammonium transporteR
L2Z06_03835	COG0642	Histidine kinase
L2Z06_03840	COG0745	RESPONSE REGULATOR receiver
L2Z06_03845	COG2194	sulfuric ester hydrolase activity
L2Z06_03865	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z06_03880	COG2315	Protein conserved in bacteria
L2Z06_03885	COG0142	geranyltranstransferase activity
L2Z06_03890	COG2828	Protein conserved in bacteria
L2Z06_03895	COG1113	amino acid transport
L2Z06_03915	COG2207	Transcriptional regulator
L2Z06_03940	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z06_03950	COG0560	Phosphoserine phosphatase
L2Z06_03960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z06_03970	COG1530	ribonuclease E activity
L2Z06_03975	COG0424	maF-like protein
L2Z06_03980	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z06_03985	COG1792	Involved in formation and maintenance of cell shape
L2Z06_03990	COG1077	Cell shape determining protein MreB Mrl
L2Z06_03995	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z06_04005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z06_04045	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z06_04050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z06_04055	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z06_04060	COG1115	amino acid carrier protein
L2Z06_04080	COG2814	Major facilitator Superfamily
L2Z06_04085	COG1289	transmembrane transporter activity
L2Z06_04095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z06_04135	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z06_04140	COG2832	Protein of unknown function (DUF454)
L2Z06_04150	COG5510	response to toxic substance
L2Z06_04170	COG0840	transmembrane signaling receptor activity
L2Z06_04210	COG3422	double-strand break repair
L2Z06_04215	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z06_04235	COG0354	folic acid binding
L2Z06_04240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z06_04250	COG0679	Auxin Efflux Carrier
L2Z06_04255	COG1902	pentaerythritol trinitrate reductase activity
L2Z06_04275	COG2094	Belongs to the DNA glycosylase MPG family
L2Z06_04300	COG1217	gtp-binding protein TYPA
L2Z06_04305	COG2233	PERMEase
L2Z06_04315	COG0833	amino acid
L2Z06_04320	COG1690	Belongs to the RtcB family
L2Z06_04330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z06_04330	COG2885	chlorophyll binding
L2Z06_04340	COG0183	Belongs to the thiolase family
L2Z06_04360	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z06_04380	COG2207	Transcriptional regulator
L2Z06_04385	COG0183	Belongs to the thiolase family
L2Z06_04415	COG1272	protein, Hemolysin III
L2Z06_04420	COG0477	Major facilitator Superfamily
L2Z06_04435	COG0450	alkyl hydroperoxide reductase
L2Z06_04455	COG0285	dihydrofolate synthase activity
L2Z06_04505	COG2096	Adenosyltransferase
L2Z06_04525	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z06_04530	COG0745	RESPONSE REGULATOR receiver
L2Z06_04535	COG2205	protein histidine kinase activity
L2Z06_04545	COG1960	acyl-CoA dehydrogenase activity
L2Z06_04550	COG1960	acyl-CoA dehydrogenase activity
L2Z06_04555	COG0583	DNA-binding transcription factor activity
L2Z06_04560	COG0625	glutathione transferase activity
L2Z06_04625	COG0438	transferase activity, transferring glycosyl groups
L2Z06_04630	COG0463	Glycosyl transferase, family 2
L2Z06_04635	COG0726	polysaccharide deacetylase
L2Z06_04655	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z06_04660	COG2205	protein histidine kinase activity
L2Z06_04690	COG1862	Preprotein translocase
L2Z06_04700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z06_04705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z06_04715	COG3781	membrane
L2Z06_04720	COG0613	PHP domain protein
L2Z06_04730	COG2350	Protein conserved in bacteria
L2Z06_04760	COG1607	acyl-coa hydrolase
L2Z06_04820	COG2199	diguanylate cyclase activity
L2Z06_04830	COG1408	metallophosphoesterase
L2Z06_04835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z06_04845	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z06_04865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z06_04870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z06_04885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z06_04895	COG2969	positive regulation of protein catabolic process
L2Z06_04915	COG1960	acyl-CoA dehydrogenase activity
L2Z06_04920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z06_04935	COG1309	transcriptional regulator
L2Z06_04940	COG1960	acyl-CoA dehydrogenase activity
L2Z06_04995	COG1183	phosphatidylcholine synthase activity
L2Z06_05000	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z06_05030	COG0741	lytic transglycosylase activity
L2Z06_05030	COG1196	nuclear chromosome segregation
L2Z06_05030	COG0739	heme binding
L2Z06_05040	COG1702	phosphate starvation-inducible protein PhoH
L2Z06_05075	COG1295	ribonuclease BN
L2Z06_05080	COG0697	spore germination
L2Z06_05085	COG2169	Transcriptional regulator
L2Z06_05090	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z06_05135	COG0557	exoribonuclease II activity
L2Z06_05140	COG0339	signal peptide processing
L2Z06_05145	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z06_05175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z06_05180	COG1960	acyl-CoA dehydrogenase activity
L2Z06_05335	COG0626	cystathionine gamma-synthase activity
L2Z06_05340	COG0433	COG0433 Predicted ATPase
L2Z06_05345	COG1017	nitric oxide dioxygenase activity
L2Z06_05345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z06_05350	COG1959	2 iron, 2 sulfur cluster binding
L2Z06_05365	COG1301	dicarboxylic acid transport
L2Z06_05370	COG1946	Acyl-CoA thioesterase
L2Z06_05390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z06_05395	COG1040	competence protein
L2Z06_05400	COG0494	nUDIX hydrolase
L2Z06_05410	COG0598	Magnesium transport protein CorA
L2Z06_05420	COG2854	intermembrane phospholipid transfer
L2Z06_05430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z06_05435	COG1127	ABC transporter
L2Z06_05445	COG0513	Belongs to the DEAD box helicase family
L2Z06_05465	COG0408	coproporphyrinogen oxidase activity
L2Z06_05480	COG1960	acyl-CoA dehydrogenase activity
L2Z06_05490	COG1983	PspC domain protein
L2Z06_05495	COG0517	IMP dehydrogenase activity
L2Z06_05540	COG0583	DNA-binding transcription factor activity
L2Z06_05580	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_05590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z06_05595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z06_05600	COG0833	amino acid
L2Z06_05630	COG1192	Involved in chromosome partitioning
L2Z06_05635	COG0628	permease
L2Z06_05645	COG1289	transmembrane transporter activity
L2Z06_05660	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z06_05665	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z06_05675	COG0277	FAD linked oxidase domain protein
L2Z06_05680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z06_05705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z06_05710	COG5380	lipid catabolic process
L2Z06_05730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z06_05780	COG0194	GDP metabolic process
L2Z06_05795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z06_05815	COG3307	-O-antigen
L2Z06_05835	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z06_05840	COG1704	LemA family
L2Z06_05860	COG0493	'glutamate synthase
L2Z06_05865	COG0069	glutamate synthase activity
L2Z06_05865	COG0070	glutamate synthase
L2Z06_05865	COG0067	glutamate synthase
L2Z06_05915	COG2226	methyltransferase
L2Z06_05930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z06_05935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z06_05980	COG0833	amino acid
L2Z06_06065	COG0488	(ABC) transporter
L2Z06_06070	COG2873	o-acetylhomoserine
L2Z06_06075	COG4221	oxidoreductase activity
L2Z06_06080	COG0659	secondary active sulfate transmembrane transporter activity
L2Z06_06105	COG0427	acetyl-CoA hydrolase
L2Z06_06135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z06_06175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z06_06230	COG2207	Transcriptional regulator
L2Z06_06235	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L2Z06_06255	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z06_06260	COG1733	regulation of RNA biosynthetic process
L2Z06_06285	COG1733	regulation of RNA biosynthetic process
L2Z06_06305	COG0667	Aldo Keto reductase
L2Z06_06335	COG0583	DNA-binding transcription factor activity
L2Z06_06340	COG2814	Major facilitator Superfamily
L2Z06_06370	COG1335	isochorismatase
L2Z06_06380	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_06385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z06_06395	COG1113	amino acid transport
L2Z06_06405	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z06_06420	COG2814	Major facilitator Superfamily
L2Z06_06430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z06_06430	COG0352	thiamine-phosphate diphosphorylase activity
L2Z06_06430	COG0351	phosphomethylpyrimidine kinase
L2Z06_06450	COG1309	transcriptional regulator
L2Z06_06455	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z06_06470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z06_06480	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z06_06485	COG3162	membrane
L2Z06_06490	COG0784	Response regulator, receiver
L2Z06_06490	COG2205	protein histidine kinase activity
L2Z06_06490	COG2198	Histidine kinase
L2Z06_06515	COG1522	sequence-specific DNA binding
L2Z06_06520	COG1335	isochorismatase
L2Z06_06525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z06_06535	COG0668	transmembrane transport
L2Z06_06540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z06_06545	COG1519	Transferase
L2Z06_06550	COG1902	pentaerythritol trinitrate reductase activity
L2Z06_06570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z06_06595	COG0426	domain, Protein
L2Z06_06595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z06_06610	COG0697	spore germination
L2Z06_06615	COG1309	transcriptional regulator
L2Z06_06630	COG0386	Belongs to the glutathione peroxidase family
L2Z06_06695	COG1121	(ABC) transporter
L2Z06_06700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z06_06705	COG1280	lysine exporter protein (LysE YggA)
L2Z06_06710	COG2837	iron assimilation
L2Z06_06720	COG0281	malic enzyme
L2Z06_06765	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z06_06765	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z06_06770	COG4399	Belongs to the UPF0754 family
L2Z06_06775	COG2259	Doxx family
L2Z06_06780	COG0586	Pfam SNARE associated Golgi protein
L2Z06_06795	COG1192	Involved in chromosome partitioning
L2Z06_06805	COG0271	Belongs to the BolA IbaG family
L2Z06_06825	COG2267	carboxylic ester hydrolase activity
L2Z06_06845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z06_06845	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z06_06845	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z06_06845	COG3321	synthase
L2Z06_06850	COG1960	acyl-CoA dehydrogenase activity
L2Z06_06865	COG2197	response regulator
L2Z06_06875	COG3916	Acyl-homoserine-lactone synthase
L2Z06_06880	COG0477	Major facilitator Superfamily
L2Z06_06885	COG1024	Enoyl-CoA hydratase
L2Z06_06890	COG1024	Enoyl-CoA hydratase
L2Z06_06895	COG1960	acyl-CoA dehydrogenase activity
L2Z06_06900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z06_06920	COG1113	amino acid transport
L2Z06_06925	COG1113	amino acid transport
L2Z06_06930	COG0251	oxidation-reduction process
L2Z06_06970	COG0564	pseudouridine synthase activity
L2Z06_07005	COG1051	belongs to the nudix hydrolase family
L2Z06_07025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z06_07040	COG1802	Transcriptional regulator
L2Z06_07050	COG1448	Aminotransferase
L2Z06_07055	COG0277	FAD linked oxidase domain protein
L2Z06_07065	COG2186	Transcriptional regulator
L2Z06_07075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z06_07080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z06_07095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z06_07100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z06_07105	COG1216	Glycosyl transferase, family 2
L2Z06_07125	COG2244	polysaccharide biosynthetic process
L2Z06_07130	COG2089	acid synthase
L2Z06_07145	COG1083	cytidylyl-transferase
L2Z06_07150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2Z06_07155	COG1086	Polysaccharide biosynthesis protein
L2Z06_07160	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z06_07190	COG0728	peptidoglycan biosynthetic process
L2Z06_07195	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z06_07250	COG0546	phosphoglycolate phosphatase activity
L2Z06_07255	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_07275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z06_07280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z06_07285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z06_07290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z06_07295	COG1116	anion transmembrane transporter activity
L2Z06_07300	COG1309	transcriptional regulator
L2Z06_07305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z06_07315	COG0196	riboflavin kinase activity
L2Z06_07320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z06_07330	COG1047	Peptidyl-prolyl cis-trans
L2Z06_07370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z06_07375	COG0657	acetylesterase activity
L2Z06_07395	COG0583	DNA-binding transcription factor activity
L2Z06_07425	COG2951	lytic endotransglycosylase activity
L2Z06_07430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z06_07445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z06_07455	COG0671	phosphoesterase, PA-phosphatase related
L2Z06_07460	COG0861	Integral membrane protein TerC family
L2Z06_07470	COG0754	glutathionylspermidine amidase activity
L2Z06_07480	COG0402	S-adenosylhomocysteine deaminase activity
L2Z06_07495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z06_07500	COG1230	cation diffusion facilitator family transporter
L2Z06_07515	COG0706	membrane insertase activity
L2Z06_07540	COG0592	DNA-directed DNA polymerase activity
L2Z06_07550	COG0187	DNA topoisomerase II activity
L2Z06_07560	COG0586	Pfam SNARE associated Golgi protein
L2Z06_07565	COG0488	(ABC) transporter
L2Z06_07590	COG0596	Alpha beta hydrolase
L2Z06_07595	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z06_07600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z06_07640	COG0733	neurotransmitter:sodium symporter activity
L2Z06_07680	COG2233	PERMEase
L2Z06_07695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z06_07730	COG2814	Major facilitator Superfamily
L2Z06_07735	COG0656	L-ascorbic acid biosynthetic process
L2Z06_07740	COG0583	DNA-binding transcription factor activity
L2Z06_07755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z06_07760	COG1064	alcohol dehydrogenase
L2Z06_07765	COG2818	Glycosylase
L2Z06_07780	COG1194	a g-specific adenine glycosylase
L2Z06_07805	COG2983	Belongs to the UPF0260 family
L2Z06_07810	COG2133	pyrroloquinoline quinone binding
L2Z06_07815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z06_07820	COG2116	formate transmembrane transporter activity
L2Z06_07845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z06_07850	COG1335	isochorismatase
L2Z06_07855	COG0385	Bile acid
L2Z06_07860	COG0534	Mate efflux family protein
L2Z06_07865	COG1683	Conserved Protein
L2Z06_07885	COG0625	glutathione transferase activity
L2Z06_07895	COG1113	amino acid transport
L2Z06_07905	COG0523	cobalamin synthesis protein
L2Z06_07915	COG2188	Transcriptional regulator
L2Z06_07945	COG0010	Belongs to the arginase family
L2Z06_07955	COG0546	phosphoglycolate phosphatase activity
L2Z06_07960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z06_07965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z06_07975	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z06_07980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z06_08025	COG0753	catalase activity
L2Z06_08085	COG0534	Mate efflux family protein
L2Z06_08090	COG0436	Aminotransferase
L2Z06_08095	COG2733	membrane
L2Z06_08110	COG2918	glutathione biosynthetic process
L2Z06_08130	COG3179	chitinase
L2Z06_08170	COG3150	esterase
L2Z06_08180	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z06_08190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z06_08200	COG2233	PERMEase
L2Z06_08255	COG1393	Belongs to the ArsC family
L2Z06_08260	COG0708	Exodeoxyribonuclease III
L2Z06_08280	COG0189	ligase activity
L2Z06_08300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z06_08310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z06_08325	COG4942	peptidase
L2Z06_08335	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z06_08345	COG2119	membrane
L2Z06_08360	COG0758	DNA mediated transformation
L2Z06_08430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z06_08440	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z06_08480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z06_08500	COG1253	flavin adenine dinucleotide binding
L2Z06_08510	COG2860	membrane
L2Z06_08515	COG0477	Major facilitator Superfamily
L2Z06_08525	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z06_08540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z06_08560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z06_08605	COG0589	response to stress
L2Z06_08610	COG0659	secondary active sulfate transmembrane transporter activity
L2Z06_08640	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z06_08685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z06_08725	COG0589	response to stress
L2Z06_08730	COG0659	secondary active sulfate transmembrane transporter activity
L2Z06_08740	COG1002	Type II restriction enzyme, methylase subunits
L2Z06_08745	COG1061	Type III restriction enzyme res subunit
L2Z06_08820	COG0347	Belongs to the P(II) protein family
L2Z06_08825	COG0004	ammonium transporteR
L2Z06_08835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z06_08835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z06_08875	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z06_08880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z06_08885	COG0793	Belongs to the peptidase S41A family
L2Z06_08900	COG2197	response regulator
L2Z06_08910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z06_08920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z06_08925	COG4974	Belongs to the 'phage' integrase family
L2Z06_08950	COG0772	Belongs to the SEDS family
L2Z06_08955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z06_08960	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z06_08965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z06_08990	COG0697	spore germination
L2Z06_08995	COG1538	Outer membrane efflux protein
L2Z06_09015	COG3275	phosphorelay sensor kinase activity
L2Z06_09025	COG0181	hydroxymethylbilane synthase activity
L2Z06_09070	COG1716	ATPase activity
L2Z06_09075	COG0546	phosphoglycolate phosphatase activity
L2Z06_09170	COG0596	Alpha beta hydrolase
L2Z06_09175	COG2056	Na+-H+ antiporter family
L2Z06_09190	COG0326	Molecular chaperone. Has ATPase activity
L2Z06_09205	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z06_09270	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z06_09275	COG2169	Transcriptional regulator
L2Z06_09275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z06_09305	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z06_09315	COG0497	DNA recombination
L2Z06_09330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z06_09340	COG0237	dephospho-CoA kinase activity
L2Z06_09345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z06_09395	COG0195	Participates in both transcription termination and antitermination
L2Z06_09410	COG1320	monovalent cation:proton antiporter activity
L2Z06_09415	COG2212	antiporter activity
L2Z06_09420	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z06_09425	COG0651	ATP synthesis coupled electron transport
L2Z06_09430	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z06_09435	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z06_09435	COG2111	Na H antiporter
L2Z06_09450	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z06_09455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z06_09470	COG2226	methyltransferase
L2Z06_09490	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z06_09495	COG1074	ATP-dependent DNA helicase activity
L2Z06_09500	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z06_09505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z06_09525	COG0598	Magnesium transport protein CorA
L2Z06_09530	COG0789	Transcriptional regulator
L2Z06_09535	COG0484	heat shock protein binding
L2Z06_09545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z06_09550	COG0475	glutathione-regulated potassium exporter activity
L2Z06_09550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z06_09555	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z06_09575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z06_09585	COG4535	Mg2 and Co2 transporter CorC
L2Z06_09590	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z06_09595	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z06_09595	COG0644	oxidoreductase
L2Z06_09605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z06_09620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z06_09625	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z06_09665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z06_09680	COG0534	Mate efflux family protein
L2Z06_09690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z06_09695	COG4221	oxidoreductase activity
L2Z06_09700	COG0583	DNA-binding transcription factor activity
L2Z06_09715	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z06_09720	COG1530	ribonuclease E activity
L2Z06_09730	COG0546	phosphoglycolate phosphatase activity
L2Z06_09735	COG2378	regulation of single-species biofilm formation
L2Z06_09740	COG0625	glutathione transferase activity
L2Z06_09750	COG0583	DNA-binding transcription factor activity
L2Z06_09815	COG0473	3-isopropylmalate dehydrogenase activity
L2Z06_09870	COG1301	dicarboxylic acid transport
L2Z06_09880	COG1560	Kdo2-lipid A biosynthetic process
L2Z06_09885	COG1280	lysine exporter protein (LysE YggA)
L2Z06_09890	COG0488	(ABC) transporter
L2Z06_09895	COG2900	Belongs to the SlyX family
L2Z06_09905	COG1733	regulation of RNA biosynthetic process
L2Z06_09930	COG0210	DNA helicase
L2Z06_09935	COG0724	RNA recognition motif
L2Z06_09955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z06_09955	COG4651	solute:proton antiporter activity
L2Z06_09980	COG0788	formyltetrahydrofolate deformylase activity
L2Z06_10080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z06_10080	COG2813	Specifically methylates the guanine in position
L2Z06_10090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z06_10100	COG4774	siderophore transport
L2Z06_10110	COG0740	serine-type endopeptidase activity
L2Z06_10130	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z06_10130	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z06_10135	COG0280	phosphate acetyltransferase
L2Z06_10135	COG0857	belongs to the CobB CobQ family
L2Z06_10140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z06_10155	COG0800	Aldolase
L2Z06_10165	COG3265	gluconokinase activity
L2Z06_10170	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_10180	COG2267	carboxylic ester hydrolase activity
L2Z06_10195	COG0793	Belongs to the peptidase S41A family
L2Z06_10230	COG1426	Protein conserved in bacteria
L2Z06_10275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z06_10285	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z06_10300	COG2986	histidine ammonia-lyase
L2Z06_10340	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_10345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z06_10365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z06_10375	COG1162	GTPase activity
L2Z06_10380	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z06_10395	COG1538	Outer membrane efflux protein
L2Z06_10400	COG0577	efflux transmembrane transporter activity
L2Z06_10400	COG1136	(ABC) transporter
L2Z06_10405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z06_10430	COG0028	Belongs to the TPP enzyme family
L2Z06_10435	COG0440	acetolactate synthase activity
L2Z06_10465	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z06_10480	COG0084	hydrolase, TatD family'
L2Z06_10495	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z06_10505	COG0583	DNA-binding transcription factor activity
L2Z06_10515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z06_10520	COG2814	Major facilitator Superfamily
L2Z06_10530	COG0697	spore germination
L2Z06_10560	COG3622	Belongs to the hyi family
L2Z06_10565	COG2084	Dehydrogenase
L2Z06_10570	COG1024	Enoyl-CoA hydratase
L2Z06_10575	COG0784	Response regulator, receiver
L2Z06_10575	COG2205	protein histidine kinase activity
L2Z06_10575	COG5002	protein histidine kinase activity
L2Z06_10595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z06_10605	COG3956	TIGRFAM MazG family protein
L2Z06_10610	COG1555	photosystem II stabilization
L2Z06_10615	COG0617	tRNA 3'-terminal CCA addition
L2Z06_10620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z06_10640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z06_10645	COG3028	Belongs to the UPF0307 family
L2Z06_10650	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z06_10665	COG0625	glutathione transferase activity
L2Z06_10670	COG1238	metal cluster binding
L2Z06_10715	COG0072	phenylalanine-tRNA ligase activity
L2Z06_10745	COG0248	Ppx GppA phosphatase
L2Z06_10755	COG0037	tRNA processing
L2Z06_10805	COG1764	response to oxidative stress
L2Z06_10810	COG1846	Transcriptional regulator
L2Z06_10820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z06_10880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z06_10885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z06_10890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z06_10900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z06_10950	COG1214	PFAM Peptidase M22, glycoprotease
L2Z06_10975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z06_10980	COG0561	phosphatase activity
L2Z06_10990	COG2132	Multicopper oxidase
L2Z06_10995	COG3667	copper resistance
L2Z06_11010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z06_11015	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z06_11020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z06_11050	COG1063	alcohol dehydrogenase
L2Z06_11055	COG0583	DNA-binding transcription factor activity
L2Z06_11060	COG1960	acyl-CoA dehydrogenase activity
L2Z06_11065	COG2814	Major facilitator Superfamily
L2Z06_11070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z06_11080	COG1053	succinate dehydrogenase
L2Z06_11085	COG0583	DNA-binding transcription factor activity
L2Z06_11100	COG0583	DNA-binding transcription factor activity
L2Z06_11130	COG0583	DNA-binding transcription factor activity
L2Z06_11145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z06_11180	COG0384	phenazine biosynthesis protein PhzF
L2Z06_11200	COG4993	Dehydrogenase
L2Z06_11270	COG2205	protein histidine kinase activity
L2Z06_11285	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z06_11305	COG0745	RESPONSE REGULATOR receiver
L2Z06_11345	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z06_11375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z06_11380	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z06_11400	COG0583	DNA-binding transcription factor activity
L2Z06_11420	COG0668	transmembrane transport
L2Z06_11430	COG2081	HI0933 family
L2Z06_11435	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z06_11465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z06_11465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z06_11475	COG0489	protein tyrosine kinase activity
L2Z06_11525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z06_11535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z06_11550	COG0730	response to heat
L2Z06_11560	COG1196	nuclear chromosome segregation
L2Z06_11580	COG2223	nitrite transmembrane transporter activity
L2Z06_11585	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z06_11595	COG2226	methyltransferase
L2Z06_11595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z06_11595	COG0596	Alpha beta hydrolase
L2Z06_11610	COG4106	trans-aconitate 2-methyltransferase activity
L2Z06_11625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z06_11630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z06_11635	COG0009	L-threonylcarbamoyladenylate synthase
L2Z06_11640	COG3101	peptidyl-lysine hydroxylation
L2Z06_11645	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z06_11670	COG1652	LysM domain
L2Z06_11675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z06_11675	COG0352	thiamine-phosphate diphosphorylase activity
L2Z06_11675	COG0351	phosphomethylpyrimidine kinase
L2Z06_11685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z06_11715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z06_11745	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z06_11760	COG0358	DNA primase activity
L2Z06_11770	COG0564	pseudouridine synthase activity
L2Z06_11795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z06_11815	COG0583	DNA-binding transcription factor activity
L2Z06_11820	COG0473	3-isopropylmalate dehydrogenase activity
L2Z06_11830	COG0657	acetylesterase activity
L2Z06_11840	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_11860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z06_11860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z06_11875	COG1981	membrane
L2Z06_11920	COG0456	acetyltransferase
L2Z06_11930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z06_11935	COG0492	ferredoxin-NADP+ reductase activity
L2Z06_11940	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z06_11940	COG1674	ftsk spoiiie
L2Z06_11945	COG1280	lysine exporter protein (LysE YggA)
L2Z06_11970	COG2894	cell division
L2Z06_11985	COG0204	Acyl-transferase
L2Z06_11990	COG2885	chlorophyll binding
L2Z06_11995	COG0210	DNA helicase
L2Z06_12005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z06_12020	COG0121	glutamine amidotransferase
L2Z06_12040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z06_12045	COG0735	belongs to the Fur family
L2Z06_12070	COG0420	3'-5' exonuclease activity
L2Z06_12090	COG1090	epimerase
L2Z06_12105	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z06_12115	COG2814	Major facilitator Superfamily
L2Z06_12120	COG0405	Gamma-glutamyltransferase
L2Z06_12190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z06_12280	COG1484	DNA-dependent DNA replication
L2Z06_12485	COG2026	Addiction module toxin, RelE StbE family
L2Z06_12525	COG0592	DNA-directed DNA polymerase activity
L2Z06_12635	COG0582	viral genome integration into host DNA
L2Z06_12690	COG0629	single-stranded DNA binding
L2Z06_12725	COG0084	hydrolase, TatD family'
L2Z06_12745	COG0477	Major facilitator Superfamily
L2Z06_12750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z06_12760	COG1595	DNA-templated transcription, initiation
L2Z06_12815	COG0531	amino acid
L2Z06_12820	COG2040	homocysteine
L2Z06_12845	COG1309	transcriptional regulator
L2Z06_12850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z06_12855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z06_12865	COG1607	acyl-coa hydrolase
L2Z06_12875	COG0523	cobalamin synthesis protein
L2Z06_12885	COG4681	YaeQ
L2Z06_12895	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z06_12895	COG0726	polysaccharide deacetylase
L2Z06_12900	COG1215	transferase activity, transferring glycosyl groups
L2Z06_12910	COG1024	Enoyl-CoA hydratase
L2Z06_12925	COG1414	Transcriptional regulator
L2Z06_12945	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_12955	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z06_12960	COG2271	Major facilitator Superfamily
L2Z06_12970	COG2267	carboxylic ester hydrolase activity
L2Z06_12975	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_12990	COG0028	Belongs to the TPP enzyme family
L2Z06_13000	COG0477	Major facilitator Superfamily
L2Z06_13005	COG0242	peptide deformylase activity
L2Z06_13010	COG2066	Belongs to the glutaminase family
L2Z06_13015	COG2207	Transcriptional regulator
L2Z06_13020	COG2223	nitrite transmembrane transporter activity
L2Z06_13035	COG0583	DNA-binding transcription factor activity
L2Z06_13040	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_13045	COG2271	Major facilitator Superfamily
L2Z06_13050	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z06_13055	COG3958	Transketolase
L2Z06_13065	COG0306	phosphate transporter
L2Z06_13085	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z06_13130	COG4181	ATPase activity
L2Z06_13135	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z06_13160	COG0583	DNA-binding transcription factor activity
L2Z06_13170	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z06_13175	COG1773	rubredoxin
L2Z06_13230	COG2851	Citrate transporter
L2Z06_13235	COG1253	flavin adenine dinucleotide binding
L2Z06_13275	COG0804	urea catabolic process
L2Z06_13285	COG0830	nickel cation binding
L2Z06_13300	COG0742	ribosomal rna small subunit methyltransferase
L2Z06_13305	COG0768	penicillin binding
L2Z06_13330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z06_13335	COG2878	Part of a membrane complex involved in electron transport
L2Z06_13340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z06_13350	COG3384	dioxygenase
L2Z06_13375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z06_13700	COG0739	heme binding
L2Z06_13785	COG0006	proline dipeptidase activity
L2Z06_13790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z06_13795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z06_13815	COG1279	arginine transmembrane transporter activity
L2Z06_13820	COG0583	DNA-binding transcription factor activity
L2Z06_13860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z06_13865	COG0741	lytic transglycosylase activity
L2Z06_13865	COG1388	LysM domain
L2Z06_13865	COG0741	lytic transglycosylase activity
L2Z06_13865	COG1388	LysM domain
L2Z06_13875	COG4174	ABC transporter (Permease)
L2Z06_13880	COG4239	(ABC) transporter, permease
L2Z06_13885	COG4172	Belongs to the ABC transporter superfamily
L2Z06_13905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z06_13915	COG2203	Gaf domain
L2Z06_13915	COG3706	GGDEF domain
L2Z06_13915	COG4251	negative regulation of phosphorylation
L2Z06_13915	COG5001	Diguanylate cyclase
L2Z06_13925	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z06_13925	COG1902	pentaerythritol trinitrate reductase activity
L2Z06_13965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2Z06_13990	COG1309	transcriptional regulator
L2Z06_13995	COG1741	Belongs to the pirin family
L2Z06_14015	COG2072	flavoprotein involved in K transport
L2Z06_14025	COG2252	PERMEase
L2Z06_14030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z06_14035	COG3038	cytochrome b561
L2Z06_14045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z06_14055	COG0527	aspartate kinase activity
L2Z06_14065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z06_14075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z06_14090	COG0667	Aldo Keto reductase
L2Z06_14110	COG1765	OsmC-like protein
L2Z06_14125	COG0542	response to heat
L2Z06_14160	COG2885	chlorophyll binding
L2Z06_14170	COG0625	glutathione transferase activity
L2Z06_14175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z06_14195	COG3634	alkyl hydroperoxide reductase activity
L2Z06_14205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z06_14215	COG0450	alkyl hydroperoxide reductase
L2Z06_14220	COG1643	Atp-dependent helicase
L2Z06_14235	COG2814	Major facilitator Superfamily
L2Z06_14240	COG3135	benzoate transporter
L2Z06_14245	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_14250	COG0543	2 iron, 2 sulfur cluster binding
L2Z06_14250	COG0633	Ferredoxin
L2Z06_14255	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z06_14260	COG4638	Rieske (2fe-2S)
L2Z06_14270	COG0583	DNA-binding transcription factor activity
L2Z06_14320	COG1570	exodeoxyribonuclease VII activity
L2Z06_14355	COG1278	Cold shock
L2Z06_14400	COG1061	Type III restriction enzyme res subunit
L2Z06_14405	COG1002	Type II restriction enzyme, methylase subunits
L2Z06_14420	COG2814	Major facilitator Superfamily
L2Z06_14455	COG0517	IMP dehydrogenase activity
L2Z06_14455	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z06_14460	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z06_14470	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z06_14475	COG1137	ATPase activity
L2Z06_14480	COG1538	Outer membrane efflux protein
L2Z06_14510	COG4122	O-methyltransferase activity
L2Z06_14520	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z06_14535	COG1522	sequence-specific DNA binding
L2Z06_14540	COG5006	permease, DMT superfamily
L2Z06_14550	COG1560	Kdo2-lipid A biosynthetic process
L2Z06_14565	COG2814	Major facilitator Superfamily
L2Z06_14585	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z06_14635	COG0583	DNA-binding transcription factor activity
L2Z06_14640	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z06_14660	COG4770	biotin carboxylase activity
L2Z06_14665	COG0038	chloride channel
L2Z06_14685	COG1309	transcriptional regulator
L2Z06_14695	COG1063	alcohol dehydrogenase
L2Z06_14710	COG0439	Biotin carboxylase
L2Z06_14715	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z06_14735	COG0864	Transcriptional regulator
L2Z06_14745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z06_14750	COG1116	anion transmembrane transporter activity
L2Z06_14880	COG0590	tRNA wobble adenosine to inosine editing
L2Z06_14885	COG2807	transmembrane transport
L2Z06_14900	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z06_14935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z06_14955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z06_14965	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z06_14980	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_14985	COG0531	amino acid
L2Z06_14990	COG1760	l-serine dehydratase
L2Z06_14995	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_14995	COG2030	dehydratase
L2Z06_15000	COG3396	Phenylacetate-CoA oxygenase
L2Z06_15005	COG3460	Phenylacetate-CoA oxygenase
L2Z06_15010	COG3396	Phenylacetate-CoA oxygenase
L2Z06_15015	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z06_15020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z06_15025	COG1024	Enoyl-CoA hydratase
L2Z06_15030	COG1024	Enoyl-CoA hydratase
L2Z06_15035	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z06_15040	COG0183	Belongs to the thiolase family
L2Z06_15045	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z06_15050	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z06_15060	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z06_15095	COG0753	catalase activity
L2Z06_15100	COG3038	cytochrome b561
L2Z06_15120	COG2267	carboxylic ester hydrolase activity
L2Z06_15125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z06_15130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z06_15135	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_15145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z06_15155	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_15160	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z06_15165	COG0583	DNA-binding transcription factor activity
L2Z06_15175	COG1414	Transcriptional regulator
L2Z06_15180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z06_15190	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z06_15195	COG3842	ATPase activity
L2Z06_15210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z06_15215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z06_15220	COG2814	Major facilitator Superfamily
L2Z06_15225	COG1960	acyl-CoA dehydrogenase activity
L2Z06_15240	COG1024	Enoyl-CoA hydratase
L2Z06_15250	COG2814	Major facilitator Superfamily
L2Z06_15260	COG0183	Belongs to the thiolase family
L2Z06_15265	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z06_15270	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_15275	COG1024	Enoyl-CoA hydratase
L2Z06_15280	COG1960	acyl-CoA dehydrogenase activity
L2Z06_15285	COG2814	Major facilitator Superfamily
L2Z06_15290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z06_15295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z06_15305	COG2814	Major facilitator Superfamily
L2Z06_15315	COG1960	acyl-CoA dehydrogenase activity
L2Z06_15330	COG0583	DNA-binding transcription factor activity
L2Z06_15340	COG4770	biotin carboxylase activity
L2Z06_15345	COG1024	Enoyl-CoA hydratase
L2Z06_15350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z06_15355	COG1960	acyl-CoA dehydrogenase activity
L2Z06_15360	COG1309	transcriptional regulator
L2Z06_15365	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z06_15385	COG0583	DNA-binding transcription factor activity
L2Z06_15465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z06_15485	COG2205	protein histidine kinase activity
L2Z06_15485	COG0784	Response regulator, receiver
L2Z06_15505	COG0765	amino acid transport
L2Z06_15510	COG0765	amino acid transport
L2Z06_15515	COG1126	abc transporter atp-binding protein
L2Z06_15520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z06_15525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z06_15540	COG1280	lysine exporter protein (LysE YggA)
L2Z06_15550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z06_15555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z06_15560	COG1045	serine acetyltransferase
L2Z06_15575	COG0583	DNA-binding transcription factor activity
L2Z06_15580	COG0625	glutathione transferase activity
L2Z06_15585	COG0625	glutathione transferase activity
L2Z06_15590	COG0583	DNA-binding transcription factor activity
L2Z06_15600	COG1346	cytolysis
L2Z06_15620	COG2814	Major facilitator Superfamily
L2Z06_15630	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z06_15635	COG3052	prosthetic group binding
L2Z06_15655	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z06_15675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z06_15685	COG1294	oxidase, subunit
L2Z06_15690	COG1271	oxidase subunit
L2Z06_15710	COG0477	Major facilitator Superfamily
L2Z06_15720	COG4521	taurine ABC transporter
L2Z06_15725	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z06_15730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z06_15735	COG2175	clavaminate synthase activity
L2Z06_15745	COG1953	Uracil, thiamine, allantoin
L2Z06_15755	COG0583	DNA-binding transcription factor activity
L2Z06_15765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z06_15780	COG0640	Transcriptional regulator
L2Z06_15785	COG0798	PFAM Bile acid sodium symporter
L2Z06_15790	COG0583	DNA-binding transcription factor activity
L2Z06_15805	COG3634	alkyl hydroperoxide reductase activity
L2Z06_15845	COG0436	Aminotransferase
L2Z06_15855	COG0386	Belongs to the glutathione peroxidase family
L2Z06_15895	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z06_15920	COG0012	GTP binding
L2Z06_15925	COG2011	ABC-type metal ion transport system permease component
L2Z06_15930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z06_15940	COG1464	Belongs to the NlpA lipoprotein family
L2Z06_15970	COG0765	amino acid transport
L2Z06_15975	COG0765	amino acid transport
L2Z06_15980	COG1126	abc transporter atp-binding protein
L2Z06_15990	COG1522	sequence-specific DNA binding
L2Z06_16025	COG0583	DNA-binding transcription factor activity
L2Z06_16035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z06_16045	COG0697	spore germination
L2Z06_16080	COG3121	Chaperone
L2Z06_16085	COG3539	Fimbrial protein
L2Z06_16110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z06_16110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z06_16155	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z06_16165	COG2353	YceI-like domain
L2Z06_16175	COG3698	Phosphodiester glycosidase
L2Z06_16190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z06_16195	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z06_16195	COG0506	proline dehydrogenase activity
L2Z06_16195	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z06_16205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z06_16210	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z06_16230	COG1132	(ABC) transporter
L2Z06_16235	COG3122	Protein conserved in bacteria
L2Z06_16240	COG3619	membrane
L2Z06_16255	COG0640	Transcriptional regulator
L2Z06_16265	COG2850	peptidyl-arginine hydroxylation
L2Z06_16270	COG0424	maF-like protein
L2Z06_16290	COG0191	fructose-bisphosphate aldolase activity
L2Z06_16295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z06_16310	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z06_16320	COG1192	Involved in chromosome partitioning
L2Z06_16325	COG1475	DNA binding
L2Z06_16330	COG0811	peptide transport
L2Z06_16340	COG1132	(ABC) transporter
L2Z06_16345	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z06_16365	COG0084	hydrolase, TatD family'
L2Z06_16430	COG0776	regulation of translation
L2Z06_16460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z06_16465	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z06_16515	COG0339	signal peptide processing
L2Z06_16525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z06_16560	COG0702	epimerase
L2Z06_16565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z06_16585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z06_16615	COG0316	Belongs to the HesB IscA family
L2Z06_16620	COG0822	iron-sulfur transferase activity
L2Z06_16645	COG0776	regulation of translation
L2Z06_16650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z06_16655	COG2207	Transcriptional regulator
L2Z06_16660	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z06_16665	COG1960	acyl-CoA dehydrogenase activity
L2Z06_16670	COG1960	acyl-CoA dehydrogenase activity
L2Z06_16685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z06_16705	COG4264	IucA IucC family
L2Z06_16710	COG4264	IucA IucC family
L2Z06_16750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z06_16765	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z06_16785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z06_16790	COG0730	response to heat
L2Z06_16810	COG4773	Receptor
L2Z06_16815	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z06_16830	COG1131	(ABC) transporter
L2Z06_16835	COG0842	Transport permease protein
L2Z06_16840	COG0842	Transport permease protein
L2Z06_16895	COG2226	methyltransferase
L2Z06_16920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z06_16955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z06_16965	COG0133	tryptophan synthase activity
L2Z06_16980	COG3706	GGDEF domain
L2Z06_16995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z06_17000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z06_17005	COG0022	dehydrogenase e1 component
L2Z06_17010	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z06_17015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z06_17035	COG1063	alcohol dehydrogenase
L2Z06_17040	COG3781	membrane
L2Z06_17050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z06_17050	COG3453	Protein conserved in bacteria
L2Z06_17065	COG0730	response to heat
L2Z06_17080	COG2207	Transcriptional regulator
L2Z06_17080	COG3708	Transcriptional regulator
L2Z06_17085	COG1733	regulation of RNA biosynthetic process
L2Z06_17090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z06_17100	COG2188	Transcriptional regulator
L2Z06_17115	COG4521	taurine ABC transporter
L2Z06_17120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z06_17140	COG0477	Major facilitator Superfamily
L2Z06_17150	COG1027	Aspartate ammonia-lyase
L2Z06_17165	COG0583	DNA-binding transcription factor activity
L2Z06_17170	COG0583	DNA-binding transcription factor activity
L2Z06_17175	COG0183	Belongs to the thiolase family
L2Z06_17180	COG2031	fatty acid transporter
L2Z06_17185	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z06_17195	COG0583	DNA-binding transcription factor activity
L2Z06_17215	COG2610	gluconate transmembrane transporter activity
L2Z06_17220	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_17230	COG2207	Transcriptional regulator
L2Z06_17245	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_17270	COG0543	2 iron, 2 sulfur cluster binding
L2Z06_17270	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z06_17275	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z06_17280	COG4638	Rieske (2fe-2S)
L2Z06_17290	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z06_17295	COG4149	molybdate abc transporter
L2Z06_17300	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z06_17305	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_17310	COG3433	isochorismatase activity
L2Z06_17310	COG1535	isochorismatase
L2Z06_17375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z06_17390	COG0753	catalase activity
L2Z06_17400	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z06_17430	COG3539	Fimbrial protein
L2Z06_17450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z06_17470	COG2072	flavoprotein involved in K transport
L2Z06_17480	COG1538	Outer membrane efflux protein
L2Z06_17485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z06_17490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z06_17495	COG0745	RESPONSE REGULATOR receiver
L2Z06_17500	COG2205	protein histidine kinase activity
L2Z06_17510	COG2207	Transcriptional regulator
L2Z06_17525	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_17580	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z06_17710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z06_17730	COG1120	ATPase activity
L2Z06_17735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z06_17745	COG1064	alcohol dehydrogenase
L2Z06_17760	COG2207	Transcriptional regulator
L2Z06_17765	COG2084	Dehydrogenase
L2Z06_17775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z06_17780	COG0583	DNA-binding transcription factor activity
L2Z06_17790	COG0129	dihydroxy-acid dehydratase activity
L2Z06_17795	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_17810	COG1566	PFAM secretion protein HlyD family protein
L2Z06_17840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z06_17870	COG0583	DNA-binding transcription factor activity
L2Z06_17885	COG2188	Transcriptional regulator
L2Z06_17915	COG3210	domain, Protein
L2Z06_17920	COG2831	hemolysin activation secretion protein
L2Z06_17930	COG1473	amidohydrolase
L2Z06_17945	COG0475	glutathione-regulated potassium exporter activity
L2Z06_17945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z06_17955	COG0583	DNA-binding transcription factor activity
L2Z06_17960	COG1335	isochorismatase
L2Z06_17970	COG1309	transcriptional regulator
L2Z06_18000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z06_18010	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z06_18010	COG1902	pentaerythritol trinitrate reductase activity
L2Z06_18015	COG1846	Transcriptional regulator
L2Z06_18035	COG0753	catalase activity
L2Z06_18050	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_18065	COG3162	membrane
L2Z06_18075	COG3829	transcription factor binding
L2Z06_18080	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_18085	COG1960	acyl-CoA dehydrogenase activity
L2Z06_18105	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_18125	COG2186	Transcriptional regulator
L2Z06_18135	COG0583	DNA-binding transcription factor activity
L2Z06_18140	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z06_18145	COG4829	muconolactone delta-isomerase
L2Z06_18155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z06_18160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z06_18165	COG0183	Belongs to the thiolase family
L2Z06_18170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z06_18180	COG1012	belongs to the aldehyde dehydrogenase family
L2Z06_18190	COG3733	amine oxidase
L2Z06_18200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z06_18210	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z06_18220	COG4638	Rieske (2fe-2S)
L2Z06_18240	COG0154	amidase activity
L2Z06_18250	COG2814	Major facilitator Superfamily
L2Z06_18275	COG1960	acyl-CoA dehydrogenase activity
L2Z06_18280	COG0583	DNA-binding transcription factor activity
L2Z06_18285	COG1414	Transcriptional regulator
L2Z06_18300	COG2391	methyltransferase activity
L2Z06_18310	COG4993	Dehydrogenase
L2Z06_18315	COG3659	wide pore channel activity
L2Z06_18320	COG3420	alginic acid biosynthetic process
L2Z06_18325	COG0710	3-dehydroquinate dehydratase activity
L2Z06_18330	COG3485	protocatechuate 3,4-dioxygenase
L2Z06_18335	COG3485	protocatechuate 3,4-dioxygenase
L2Z06_18340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z06_18345	COG2271	Major facilitator Superfamily
L2Z06_18350	COG0596	Alpha beta hydrolase
L2Z06_18355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z06_18360	COG0183	Belongs to the thiolase family
L2Z06_18365	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z06_18370	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z06_18380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z06_18385	COG2323	membrane
L2Z06_18430	COG1902	pentaerythritol trinitrate reductase activity
L2Z06_18430	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z06_18455	COG0542	response to heat
L2Z06_18460	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z06_18490	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z06_18495	COG0569	domain protein
L2Z06_18500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z06_18515	COG4774	siderophore transport
L2Z06_18520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z06_18530	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z06_18550	COG1294	oxidase, subunit
L2Z06_18555	COG4890	Cyd operon protein YbgT
L2Z06_18570	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z06_18580	COG0552	protein localization to endoplasmic reticulum
L2Z06_18605	COG0516	GMP reductase activity
L2Z06_18605	COG0517	IMP dehydrogenase activity
L2Z06_18610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z06_18615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z06_18625	COG0583	DNA-binding transcription factor activity
L2Z06_18630	COG0024	Methionine aminopeptidase
L2Z06_18660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z06_18660	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z06_18665	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z06_18670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z06_18670	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z06_18670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z06_18690	COG5001	Diguanylate cyclase
L2Z06_18690	COG3300	MHYT domain
L2Z06_18705	COG2135	peptidase activity
L2Z06_18710	COG0659	secondary active sulfate transmembrane transporter activity
L2Z06_18730	COG1113	amino acid transport
L2Z06_18740	COG1522	sequence-specific DNA binding
L2Z06_18765	COG1011	Hydrolase
L2Z06_18770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z06_18780	COG2137	regulation of response to DNA damage stimulus
L2Z06_18795	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z06_18830	COG0575	Belongs to the CDS family
L2Z06_18835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z06_18855	COG3852	Histidine kinase
L2Z06_18860	COG2204	response regulator
L2Z06_18925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z06_18930	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z06_18950	COG0697	spore germination
L2Z06_18955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z06_18965	COG0303	'Molybdopterin
L2Z06_18970	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z06_18970	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z06_18985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z06_18990	COG0243	molybdopterin cofactor binding
L2Z06_19000	COG0243	molybdopterin cofactor binding
L2Z06_19005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z06_19010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z06_19010	COG2146	nitrite reductase [NAD(P)H] activity
L2Z06_19020	COG0745	RESPONSE REGULATOR receiver
L2Z06_19025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z06_19025	COG1116	anion transmembrane transporter activity
L2Z06_19045	COG0511	ligase activity, forming carbon-carbon bonds
L2Z06_19060	COG2814	Major facilitator Superfamily