locus-tag	class	description
L2Z09_00035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z09_00045	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z09_00085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z09_00095	COG2814	Major facilitator Superfamily
L2Z09_00105	COG1253	flavin adenine dinucleotide binding
L2Z09_00115	COG2860	membrane
L2Z09_00120	COG0477	Major facilitator Superfamily
L2Z09_00130	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z09_00145	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z09_00165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z09_00175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z09_00220	COG0589	response to stress
L2Z09_00225	COG0659	secondary active sulfate transmembrane transporter activity
L2Z09_00285	COG0347	Belongs to the P(II) protein family
L2Z09_00290	COG0004	ammonium transporteR
L2Z09_00300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z09_00300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z09_00340	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z09_00345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z09_00350	COG0793	Belongs to the peptidase S41A family
L2Z09_00365	COG2197	response regulator
L2Z09_00375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z09_00385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z09_00390	COG4974	Belongs to the 'phage' integrase family
L2Z09_00415	COG0772	Belongs to the SEDS family
L2Z09_00420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z09_00425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z09_00430	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z09_00455	COG0697	spore germination
L2Z09_00460	COG1538	Outer membrane efflux protein
L2Z09_00480	COG3275	phosphorelay sensor kinase activity
L2Z09_00490	COG0181	hydroxymethylbilane synthase activity
L2Z09_00535	COG1716	ATPase activity
L2Z09_00540	COG0546	phosphoglycolate phosphatase activity
L2Z09_00645	COG0596	Alpha beta hydrolase
L2Z09_00650	COG2056	Na+-H+ antiporter family
L2Z09_00665	COG0326	Molecular chaperone. Has ATPase activity
L2Z09_00680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z09_00745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z09_00750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z09_00750	COG2169	Transcriptional regulator
L2Z09_00780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z09_00790	COG0497	DNA recombination
L2Z09_00805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z09_00815	COG0237	dephospho-CoA kinase activity
L2Z09_00820	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z09_00870	COG0195	Participates in both transcription termination and antitermination
L2Z09_00885	COG1320	monovalent cation:proton antiporter activity
L2Z09_00890	COG2212	antiporter activity
L2Z09_00895	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z09_00900	COG0651	ATP synthesis coupled electron transport
L2Z09_00905	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z09_00910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z09_00910	COG2111	Na H antiporter
L2Z09_00925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z09_00930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z09_00945	COG2226	methyltransferase
L2Z09_00965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z09_00970	COG1074	ATP-dependent DNA helicase activity
L2Z09_00975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z09_00980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z09_00995	COG0598	Magnesium transport protein CorA
L2Z09_01000	COG0789	Transcriptional regulator
L2Z09_01005	COG0484	heat shock protein binding
L2Z09_01015	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z09_01020	COG0475	glutathione-regulated potassium exporter activity
L2Z09_01020	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z09_01025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z09_01045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z09_01055	COG4535	Mg2 and Co2 transporter CorC
L2Z09_01060	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z09_01065	COG0644	oxidoreductase
L2Z09_01065	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z09_01075	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z09_01090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z09_01095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z09_01135	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z09_01150	COG0534	Mate efflux family protein
L2Z09_01160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z09_01165	COG4221	oxidoreductase activity
L2Z09_01170	COG0583	DNA-binding transcription factor activity
L2Z09_01185	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z09_01190	COG1530	ribonuclease E activity
L2Z09_01200	COG0546	phosphoglycolate phosphatase activity
L2Z09_01205	COG2378	regulation of single-species biofilm formation
L2Z09_01210	COG0625	glutathione transferase activity
L2Z09_01220	COG0583	DNA-binding transcription factor activity
L2Z09_01285	COG0473	3-isopropylmalate dehydrogenase activity
L2Z09_01340	COG1301	dicarboxylic acid transport
L2Z09_01350	COG1560	Kdo2-lipid A biosynthetic process
L2Z09_01355	COG1280	lysine exporter protein (LysE YggA)
L2Z09_01360	COG0488	(ABC) transporter
L2Z09_01365	COG2900	Belongs to the SlyX family
L2Z09_01375	COG1733	regulation of RNA biosynthetic process
L2Z09_01400	COG0210	DNA helicase
L2Z09_01405	COG0724	RNA recognition motif
L2Z09_01425	COG4651	solute:proton antiporter activity
L2Z09_01425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z09_01450	COG0788	formyltetrahydrofolate deformylase activity
L2Z09_01550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z09_01550	COG2813	Specifically methylates the guanine in position
L2Z09_01560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z09_01580	COG0740	serine-type endopeptidase activity
L2Z09_01600	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z09_01600	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z09_01605	COG0857	belongs to the CobB CobQ family
L2Z09_01605	COG0280	phosphate acetyltransferase
L2Z09_01610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z09_01620	COG0800	Aldolase
L2Z09_01630	COG3265	gluconokinase activity
L2Z09_01635	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_01645	COG2267	carboxylic ester hydrolase activity
L2Z09_01660	COG0793	Belongs to the peptidase S41A family
L2Z09_01695	COG1426	Protein conserved in bacteria
L2Z09_01740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z09_01755	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z09_01770	COG2986	histidine ammonia-lyase
L2Z09_01810	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_01815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z09_01835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z09_01845	COG1162	GTPase activity
L2Z09_01850	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z09_01865	COG1538	Outer membrane efflux protein
L2Z09_01870	COG1136	(ABC) transporter
L2Z09_01870	COG0577	efflux transmembrane transporter activity
L2Z09_01875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z09_01900	COG0028	Belongs to the TPP enzyme family
L2Z09_01905	COG0440	acetolactate synthase activity
L2Z09_01935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z09_01950	COG0084	hydrolase, TatD family'
L2Z09_01970	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z09_01980	COG0583	DNA-binding transcription factor activity
L2Z09_01990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z09_01995	COG2814	Major facilitator Superfamily
L2Z09_02005	COG0697	spore germination
L2Z09_02035	COG3622	Belongs to the hyi family
L2Z09_02040	COG2084	Dehydrogenase
L2Z09_02045	COG1024	Enoyl-CoA hydratase
L2Z09_02050	COG0784	Response regulator, receiver
L2Z09_02050	COG2205	protein histidine kinase activity
L2Z09_02050	COG5002	protein histidine kinase activity
L2Z09_02070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z09_02080	COG3956	TIGRFAM MazG family protein
L2Z09_02085	COG1555	photosystem II stabilization
L2Z09_02090	COG0617	tRNA 3'-terminal CCA addition
L2Z09_02095	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z09_02115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z09_02120	COG3028	Belongs to the UPF0307 family
L2Z09_02125	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z09_02140	COG0625	glutathione transferase activity
L2Z09_02145	COG1238	metal cluster binding
L2Z09_02190	COG0072	phenylalanine-tRNA ligase activity
L2Z09_02220	COG0248	Ppx GppA phosphatase
L2Z09_02230	COG0037	tRNA processing
L2Z09_02270	COG1764	response to oxidative stress
L2Z09_02275	COG1846	Transcriptional regulator
L2Z09_02285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z09_02345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z09_02350	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z09_02355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z09_02365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z09_02415	COG1214	PFAM Peptidase M22, glycoprotease
L2Z09_02440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z09_02445	COG0561	phosphatase activity
L2Z09_02455	COG2132	Multicopper oxidase
L2Z09_02460	COG3667	copper resistance
L2Z09_02475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z09_02480	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z09_02485	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z09_02515	COG1063	alcohol dehydrogenase
L2Z09_02520	COG0583	DNA-binding transcription factor activity
L2Z09_02525	COG1960	acyl-CoA dehydrogenase activity
L2Z09_02530	COG2814	Major facilitator Superfamily
L2Z09_02535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z09_02545	COG1053	succinate dehydrogenase
L2Z09_02550	COG0583	DNA-binding transcription factor activity
L2Z09_02565	COG0583	DNA-binding transcription factor activity
L2Z09_02595	COG0583	DNA-binding transcription factor activity
L2Z09_02610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z09_02635	COG0384	phenazine biosynthesis protein PhzF
L2Z09_02655	COG4993	Dehydrogenase
L2Z09_02720	COG2205	protein histidine kinase activity
L2Z09_02730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z09_02750	COG0745	RESPONSE REGULATOR receiver
L2Z09_02790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z09_02820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z09_02825	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z09_02845	COG0583	DNA-binding transcription factor activity
L2Z09_02865	COG0668	transmembrane transport
L2Z09_02875	COG2081	HI0933 family
L2Z09_02880	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z09_02910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z09_02910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z09_02920	COG0489	protein tyrosine kinase activity
L2Z09_02970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z09_02980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z09_02995	COG0730	response to heat
L2Z09_03005	COG1196	nuclear chromosome segregation
L2Z09_03025	COG2223	nitrite transmembrane transporter activity
L2Z09_03030	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z09_03040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z09_03040	COG0596	Alpha beta hydrolase
L2Z09_03040	COG2226	methyltransferase
L2Z09_03055	COG4106	trans-aconitate 2-methyltransferase activity
L2Z09_03070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z09_03075	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z09_03080	COG0009	L-threonylcarbamoyladenylate synthase
L2Z09_03085	COG3101	peptidyl-lysine hydroxylation
L2Z09_03090	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z09_03115	COG1652	LysM domain
L2Z09_03120	COG0351	phosphomethylpyrimidine kinase
L2Z09_03120	COG0352	thiamine-phosphate diphosphorylase activity
L2Z09_03120	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z09_03130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z09_03160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z09_03190	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z09_03205	COG0358	DNA primase activity
L2Z09_03215	COG0564	pseudouridine synthase activity
L2Z09_03240	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z09_03260	COG0583	DNA-binding transcription factor activity
L2Z09_03265	COG0473	3-isopropylmalate dehydrogenase activity
L2Z09_03275	COG0657	acetylesterase activity
L2Z09_03285	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_03305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z09_03305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z09_03320	COG1981	membrane
L2Z09_03365	COG0456	acetyltransferase
L2Z09_03375	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z09_03380	COG0492	ferredoxin-NADP+ reductase activity
L2Z09_03385	COG1674	ftsk spoiiie
L2Z09_03385	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z09_03390	COG1280	lysine exporter protein (LysE YggA)
L2Z09_03415	COG2894	cell division
L2Z09_03430	COG0204	Acyl-transferase
L2Z09_03435	COG2885	chlorophyll binding
L2Z09_03440	COG0210	DNA helicase
L2Z09_03450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z09_03465	COG0121	glutamine amidotransferase
L2Z09_03485	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z09_03490	COG0735	belongs to the Fur family
L2Z09_03515	COG0420	3'-5' exonuclease activity
L2Z09_03535	COG1090	epimerase
L2Z09_03550	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z09_03560	COG2814	Major facilitator Superfamily
L2Z09_03565	COG0405	Gamma-glutamyltransferase
L2Z09_03575	COG0582	viral genome integration into host DNA
L2Z09_03610	COG2801	Transposase and inactivated derivatives
L2Z09_03630	COG0629	single-stranded DNA binding
L2Z09_03690	COG0477	Major facilitator Superfamily
L2Z09_03695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z09_03720	COG0531	amino acid
L2Z09_03725	COG2040	homocysteine
L2Z09_03750	COG1309	transcriptional regulator
L2Z09_03755	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z09_03760	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z09_03770	COG1607	acyl-coa hydrolase
L2Z09_03780	COG0523	cobalamin synthesis protein
L2Z09_03790	COG4681	YaeQ
L2Z09_03800	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z09_03800	COG0726	polysaccharide deacetylase
L2Z09_03805	COG1215	transferase activity, transferring glycosyl groups
L2Z09_03815	COG1024	Enoyl-CoA hydratase
L2Z09_03830	COG1414	Transcriptional regulator
L2Z09_03850	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_03860	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z09_03865	COG2271	Major facilitator Superfamily
L2Z09_03875	COG2267	carboxylic ester hydrolase activity
L2Z09_03880	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_03895	COG0028	Belongs to the TPP enzyme family
L2Z09_03905	COG0477	Major facilitator Superfamily
L2Z09_03910	COG0242	peptide deformylase activity
L2Z09_03915	COG2066	Belongs to the glutaminase family
L2Z09_03920	COG2207	Transcriptional regulator
L2Z09_03925	COG2223	nitrite transmembrane transporter activity
L2Z09_03940	COG0583	DNA-binding transcription factor activity
L2Z09_03945	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_03950	COG2271	Major facilitator Superfamily
L2Z09_03955	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z09_03960	COG3958	Transketolase
L2Z09_03970	COG0306	phosphate transporter
L2Z09_03990	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z09_04035	COG4181	ATPase activity
L2Z09_04040	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z09_04065	COG0583	DNA-binding transcription factor activity
L2Z09_04075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z09_04080	COG1773	rubredoxin
L2Z09_04130	COG2851	Citrate transporter
L2Z09_04135	COG1253	flavin adenine dinucleotide binding
L2Z09_04175	COG0804	urea catabolic process
L2Z09_04185	COG0830	nickel cation binding
L2Z09_04200	COG0742	ribosomal rna small subunit methyltransferase
L2Z09_04205	COG0768	penicillin binding
L2Z09_04230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z09_04235	COG2878	Part of a membrane complex involved in electron transport
L2Z09_04240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z09_04250	COG3384	dioxygenase
L2Z09_04280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z09_04605	COG0739	heme binding
L2Z09_04690	COG0006	proline dipeptidase activity
L2Z09_04695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z09_04700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z09_04720	COG1279	arginine transmembrane transporter activity
L2Z09_04725	COG0583	DNA-binding transcription factor activity
L2Z09_04765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z09_04770	COG1388	LysM domain
L2Z09_04770	COG0741	lytic transglycosylase activity
L2Z09_04770	COG1388	LysM domain
L2Z09_04770	COG0741	lytic transglycosylase activity
L2Z09_04780	COG4174	ABC transporter (Permease)
L2Z09_04785	COG4239	(ABC) transporter, permease
L2Z09_04790	COG4172	Belongs to the ABC transporter superfamily
L2Z09_04810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z09_04820	COG5001	Diguanylate cyclase
L2Z09_04820	COG3706	GGDEF domain
L2Z09_04820	COG2203	Gaf domain
L2Z09_04820	COG4251	negative regulation of phosphorylation
L2Z09_04830	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z09_04830	COG1902	pentaerythritol trinitrate reductase activity
L2Z09_04845	COG4269	membrane
L2Z09_04875	COG3209	COG3209 Rhs family protein
L2Z09_04925	COG1113	amino acid transport
L2Z09_04935	COG0531	amino acid
L2Z09_04955	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_05080	COG0300	oxidoreductase activity
L2Z09_05090	COG1309	transcriptional regulator
L2Z09_05095	COG1741	Belongs to the pirin family
L2Z09_05110	COG2072	flavoprotein involved in K transport
L2Z09_05120	COG2252	PERMEase
L2Z09_05125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z09_05130	COG3038	cytochrome b561
L2Z09_05140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z09_05150	COG0527	aspartate kinase activity
L2Z09_05160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z09_05170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z09_05185	COG0667	Aldo Keto reductase
L2Z09_05205	COG1765	OsmC-like protein
L2Z09_05220	COG0542	response to heat
L2Z09_05255	COG2885	chlorophyll binding
L2Z09_05265	COG0625	glutathione transferase activity
L2Z09_05270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z09_05290	COG3634	alkyl hydroperoxide reductase activity
L2Z09_05300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z09_05310	COG0450	alkyl hydroperoxide reductase
L2Z09_05315	COG1643	Atp-dependent helicase
L2Z09_05330	COG2814	Major facilitator Superfamily
L2Z09_05335	COG3135	benzoate transporter
L2Z09_05340	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_05345	COG0543	2 iron, 2 sulfur cluster binding
L2Z09_05345	COG0633	Ferredoxin
L2Z09_05350	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z09_05355	COG4638	Rieske (2fe-2S)
L2Z09_05365	COG0583	DNA-binding transcription factor activity
L2Z09_05415	COG1570	exodeoxyribonuclease VII activity
L2Z09_05450	COG1278	Cold shock
L2Z09_05485	COG2814	Major facilitator Superfamily
L2Z09_05520	COG0517	IMP dehydrogenase activity
L2Z09_05520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z09_05525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z09_05535	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z09_05540	COG1137	ATPase activity
L2Z09_05545	COG1538	Outer membrane efflux protein
L2Z09_05575	COG4122	O-methyltransferase activity
L2Z09_05585	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z09_05600	COG1522	sequence-specific DNA binding
L2Z09_05605	COG5006	permease, DMT superfamily
L2Z09_05615	COG1560	Kdo2-lipid A biosynthetic process
L2Z09_05630	COG2814	Major facilitator Superfamily
L2Z09_05650	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z09_05700	COG0583	DNA-binding transcription factor activity
L2Z09_05705	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z09_05725	COG4770	biotin carboxylase activity
L2Z09_05730	COG0038	chloride channel
L2Z09_05750	COG1309	transcriptional regulator
L2Z09_05775	COG0439	Biotin carboxylase
L2Z09_05780	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z09_05800	COG0864	Transcriptional regulator
L2Z09_05810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z09_05815	COG1116	anion transmembrane transporter activity
L2Z09_05935	COG0590	tRNA wobble adenosine to inosine editing
L2Z09_05940	COG2807	transmembrane transport
L2Z09_05955	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z09_05970	COG0789	Transcriptional regulator
L2Z09_05980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z09_06000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z09_06010	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z09_06025	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_06030	COG0531	amino acid
L2Z09_06035	COG1760	l-serine dehydratase
L2Z09_06040	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_06040	COG2030	dehydratase
L2Z09_06045	COG3396	Phenylacetate-CoA oxygenase
L2Z09_06050	COG3460	Phenylacetate-CoA oxygenase
L2Z09_06055	COG3396	Phenylacetate-CoA oxygenase
L2Z09_06060	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z09_06065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z09_06070	COG1024	Enoyl-CoA hydratase
L2Z09_06075	COG1024	Enoyl-CoA hydratase
L2Z09_06080	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z09_06085	COG0183	Belongs to the thiolase family
L2Z09_06090	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z09_06095	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z09_06105	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z09_06140	COG0753	catalase activity
L2Z09_06145	COG3038	cytochrome b561
L2Z09_06165	COG2267	carboxylic ester hydrolase activity
L2Z09_06170	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z09_06175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z09_06180	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_06190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z09_06200	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_06205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z09_06210	COG0583	DNA-binding transcription factor activity
L2Z09_06220	COG1414	Transcriptional regulator
L2Z09_06225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z09_06235	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z09_06240	COG3842	ATPase activity
L2Z09_06255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z09_06260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z09_06265	COG2814	Major facilitator Superfamily
L2Z09_06270	COG1960	acyl-CoA dehydrogenase activity
L2Z09_06285	COG1024	Enoyl-CoA hydratase
L2Z09_06315	COG0183	Belongs to the thiolase family
L2Z09_06320	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z09_06325	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_06330	COG1024	Enoyl-CoA hydratase
L2Z09_06335	COG1960	acyl-CoA dehydrogenase activity
L2Z09_06340	COG2814	Major facilitator Superfamily
L2Z09_06345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z09_06350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z09_06360	COG2814	Major facilitator Superfamily
L2Z09_06370	COG1960	acyl-CoA dehydrogenase activity
L2Z09_06385	COG0583	DNA-binding transcription factor activity
L2Z09_06405	COG0183	Belongs to the thiolase family
L2Z09_06410	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z09_06415	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_06420	COG1024	Enoyl-CoA hydratase
L2Z09_06425	COG1960	acyl-CoA dehydrogenase activity
L2Z09_06430	COG2814	Major facilitator Superfamily
L2Z09_06435	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z09_06440	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z09_06450	COG2814	Major facilitator Superfamily
L2Z09_06460	COG1960	acyl-CoA dehydrogenase activity
L2Z09_06475	COG0583	DNA-binding transcription factor activity
L2Z09_06490	COG4770	biotin carboxylase activity
L2Z09_06495	COG1024	Enoyl-CoA hydratase
L2Z09_06500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z09_06505	COG1960	acyl-CoA dehydrogenase activity
L2Z09_06510	COG1309	transcriptional regulator
L2Z09_06515	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z09_06535	COG0583	DNA-binding transcription factor activity
L2Z09_06585	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_06605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z09_06625	COG2205	protein histidine kinase activity
L2Z09_06625	COG0784	Response regulator, receiver
L2Z09_06645	COG0765	amino acid transport
L2Z09_06650	COG0765	amino acid transport
L2Z09_06655	COG1126	abc transporter atp-binding protein
L2Z09_06660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z09_06665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z09_06680	COG1280	lysine exporter protein (LysE YggA)
L2Z09_06690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z09_06695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z09_06700	COG1045	serine acetyltransferase
L2Z09_06715	COG0583	DNA-binding transcription factor activity
L2Z09_06720	COG0625	glutathione transferase activity
L2Z09_06725	COG0625	glutathione transferase activity
L2Z09_06730	COG0583	DNA-binding transcription factor activity
L2Z09_06740	COG1346	cytolysis
L2Z09_06760	COG2814	Major facilitator Superfamily
L2Z09_06770	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z09_06775	COG3052	prosthetic group binding
L2Z09_06795	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z09_06815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z09_06825	COG1294	oxidase, subunit
L2Z09_06830	COG1271	oxidase subunit
L2Z09_06850	COG0477	Major facilitator Superfamily
L2Z09_06870	COG4521	taurine ABC transporter
L2Z09_06875	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z09_06880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z09_06885	COG2175	clavaminate synthase activity
L2Z09_06895	COG1953	Uracil, thiamine, allantoin
L2Z09_06905	COG0583	DNA-binding transcription factor activity
L2Z09_06915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z09_06930	COG0640	Transcriptional regulator
L2Z09_06935	COG0798	PFAM Bile acid sodium symporter
L2Z09_06940	COG0583	DNA-binding transcription factor activity
L2Z09_06955	COG3634	alkyl hydroperoxide reductase activity
L2Z09_06995	COG0436	Aminotransferase
L2Z09_07005	COG0386	Belongs to the glutathione peroxidase family
L2Z09_07045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z09_07070	COG0012	GTP binding
L2Z09_07075	COG2011	ABC-type metal ion transport system permease component
L2Z09_07080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z09_07090	COG1464	Belongs to the NlpA lipoprotein family
L2Z09_07120	COG0765	amino acid transport
L2Z09_07125	COG0765	amino acid transport
L2Z09_07130	COG1126	abc transporter atp-binding protein
L2Z09_07140	COG1522	sequence-specific DNA binding
L2Z09_07175	COG0583	DNA-binding transcription factor activity
L2Z09_07185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z09_07195	COG0697	spore germination
L2Z09_07220	COG3121	Chaperone
L2Z09_07225	COG3539	Fimbrial protein
L2Z09_07250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z09_07250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z09_07295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z09_07305	COG2353	YceI-like domain
L2Z09_07315	COG3698	Phosphodiester glycosidase
L2Z09_07330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z09_07335	COG0506	proline dehydrogenase activity
L2Z09_07335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z09_07335	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z09_07345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z09_07350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z09_07370	COG1132	(ABC) transporter
L2Z09_07375	COG3122	Protein conserved in bacteria
L2Z09_07380	COG3619	membrane
L2Z09_07390	COG0640	Transcriptional regulator
L2Z09_07400	COG2850	peptidyl-arginine hydroxylation
L2Z09_07405	COG0424	maF-like protein
L2Z09_07425	COG0191	fructose-bisphosphate aldolase activity
L2Z09_07430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z09_07445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z09_07455	COG1192	Involved in chromosome partitioning
L2Z09_07460	COG1475	DNA binding
L2Z09_07465	COG0811	peptide transport
L2Z09_07475	COG1132	(ABC) transporter
L2Z09_07480	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z09_07500	COG0084	hydrolase, TatD family'
L2Z09_07565	COG0776	regulation of translation
L2Z09_07605	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z09_07610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z09_07660	COG0339	signal peptide processing
L2Z09_07670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z09_07705	COG0702	epimerase
L2Z09_07710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z09_07730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z09_07760	COG0316	Belongs to the HesB IscA family
L2Z09_07765	COG0822	iron-sulfur transferase activity
L2Z09_07790	COG0776	regulation of translation
L2Z09_07795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z09_07800	COG2207	Transcriptional regulator
L2Z09_07805	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z09_07810	COG1960	acyl-CoA dehydrogenase activity
L2Z09_07815	COG1960	acyl-CoA dehydrogenase activity
L2Z09_07830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z09_07850	COG4264	IucA IucC family
L2Z09_07855	COG4264	IucA IucC family
L2Z09_07895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z09_07910	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z09_07940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z09_07945	COG0730	response to heat
L2Z09_07965	COG4773	Receptor
L2Z09_07970	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z09_07985	COG1131	(ABC) transporter
L2Z09_07990	COG0842	Transport permease protein
L2Z09_07995	COG0842	Transport permease protein
L2Z09_08050	COG2226	methyltransferase
L2Z09_08075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z09_08115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z09_08125	COG0133	tryptophan synthase activity
L2Z09_08140	COG3706	GGDEF domain
L2Z09_08155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z09_08160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z09_08165	COG0022	dehydrogenase e1 component
L2Z09_08170	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z09_08175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z09_08185	COG1063	alcohol dehydrogenase
L2Z09_08190	COG3781	membrane
L2Z09_08200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z09_08200	COG3453	Protein conserved in bacteria
L2Z09_08215	COG0730	response to heat
L2Z09_08230	COG3708	Transcriptional regulator
L2Z09_08230	COG2207	Transcriptional regulator
L2Z09_08235	COG1733	regulation of RNA biosynthetic process
L2Z09_08240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z09_08250	COG2188	Transcriptional regulator
L2Z09_08265	COG4521	taurine ABC transporter
L2Z09_08270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z09_08290	COG0477	Major facilitator Superfamily
L2Z09_08300	COG1027	Aspartate ammonia-lyase
L2Z09_08315	COG0583	DNA-binding transcription factor activity
L2Z09_08320	COG0583	DNA-binding transcription factor activity
L2Z09_08325	COG0183	Belongs to the thiolase family
L2Z09_08330	COG2031	fatty acid transporter
L2Z09_08335	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z09_08345	COG0583	DNA-binding transcription factor activity
L2Z09_08360	COG2207	Transcriptional regulator
L2Z09_08375	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_08400	COG0543	2 iron, 2 sulfur cluster binding
L2Z09_08400	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z09_08405	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z09_08410	COG4638	Rieske (2fe-2S)
L2Z09_08420	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z09_08425	COG4149	molybdate abc transporter
L2Z09_08430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z09_08435	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_08440	COG1535	isochorismatase
L2Z09_08440	COG3433	isochorismatase activity
L2Z09_08500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z09_08515	COG0753	catalase activity
L2Z09_08525	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z09_08555	COG3539	Fimbrial protein
L2Z09_08575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z09_08595	COG2072	flavoprotein involved in K transport
L2Z09_08605	COG1538	Outer membrane efflux protein
L2Z09_08610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z09_08615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z09_08620	COG0745	RESPONSE REGULATOR receiver
L2Z09_08625	COG2205	protein histidine kinase activity
L2Z09_08635	COG2207	Transcriptional regulator
L2Z09_08650	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_08705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z09_08835	COG0739	heme binding
L2Z09_08835	COG0741	lytic transglycosylase activity
L2Z09_08835	COG1196	nuclear chromosome segregation
L2Z09_08850	COG1598	PFAM Uncharacterised protein family UPF0150
L2Z09_08955	COG5410	chromosome segregation
L2Z09_09200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z09_09220	COG1120	ATPase activity
L2Z09_09225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z09_09235	COG1064	alcohol dehydrogenase
L2Z09_09250	COG2207	Transcriptional regulator
L2Z09_09255	COG2084	Dehydrogenase
L2Z09_09265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z09_09270	COG0583	DNA-binding transcription factor activity
L2Z09_09280	COG0129	dihydroxy-acid dehydratase activity
L2Z09_09285	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_09300	COG1566	PFAM secretion protein HlyD family protein
L2Z09_09330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z09_09360	COG0583	DNA-binding transcription factor activity
L2Z09_09375	COG2188	Transcriptional regulator
L2Z09_09415	COG3210	domain, Protein
L2Z09_09420	COG2831	hemolysin activation secretion protein
L2Z09_09430	COG1473	amidohydrolase
L2Z09_09440	COG0475	glutathione-regulated potassium exporter activity
L2Z09_09440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z09_09450	COG0583	DNA-binding transcription factor activity
L2Z09_09455	COG1335	isochorismatase
L2Z09_09465	COG1309	transcriptional regulator
L2Z09_09495	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z09_09505	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z09_09505	COG1902	pentaerythritol trinitrate reductase activity
L2Z09_09510	COG1846	Transcriptional regulator
L2Z09_09530	COG0753	catalase activity
L2Z09_09545	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_09560	COG3162	membrane
L2Z09_09570	COG3829	transcription factor binding
L2Z09_09575	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_09580	COG1960	acyl-CoA dehydrogenase activity
L2Z09_09600	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_09620	COG2186	Transcriptional regulator
L2Z09_09630	COG0583	DNA-binding transcription factor activity
L2Z09_09635	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z09_09640	COG4829	muconolactone delta-isomerase
L2Z09_09650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z09_09655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z09_09660	COG0183	Belongs to the thiolase family
L2Z09_09665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z09_09675	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_09685	COG3733	amine oxidase
L2Z09_09695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z09_09705	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_09715	COG4638	Rieske (2fe-2S)
L2Z09_09735	COG0154	amidase activity
L2Z09_09745	COG2814	Major facilitator Superfamily
L2Z09_09770	COG1960	acyl-CoA dehydrogenase activity
L2Z09_09775	COG0583	DNA-binding transcription factor activity
L2Z09_09780	COG1414	Transcriptional regulator
L2Z09_09795	COG2391	methyltransferase activity
L2Z09_09805	COG4993	Dehydrogenase
L2Z09_09810	COG3659	wide pore channel activity
L2Z09_09815	COG3420	alginic acid biosynthetic process
L2Z09_09820	COG0710	3-dehydroquinate dehydratase activity
L2Z09_09825	COG3485	protocatechuate 3,4-dioxygenase
L2Z09_09830	COG3485	protocatechuate 3,4-dioxygenase
L2Z09_09835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z09_09840	COG2271	Major facilitator Superfamily
L2Z09_09845	COG0596	Alpha beta hydrolase
L2Z09_09850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z09_09855	COG0183	Belongs to the thiolase family
L2Z09_09860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z09_09865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z09_09875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z09_09880	COG2323	membrane
L2Z09_09925	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z09_09925	COG1902	pentaerythritol trinitrate reductase activity
L2Z09_09950	COG0542	response to heat
L2Z09_09955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z09_09985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z09_09990	COG0569	domain protein
L2Z09_09995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z09_10010	COG4774	siderophore transport
L2Z09_10015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z09_10025	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z09_10045	COG1294	oxidase, subunit
L2Z09_10050	COG4890	Cyd operon protein YbgT
L2Z09_10065	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z09_10075	COG0552	protein localization to endoplasmic reticulum
L2Z09_10100	COG0516	GMP reductase activity
L2Z09_10100	COG0517	IMP dehydrogenase activity
L2Z09_10105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z09_10110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z09_10120	COG0583	DNA-binding transcription factor activity
L2Z09_10125	COG0024	Methionine aminopeptidase
L2Z09_10155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z09_10155	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z09_10160	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z09_10165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z09_10165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z09_10165	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z09_10185	COG5001	Diguanylate cyclase
L2Z09_10185	COG3300	MHYT domain
L2Z09_10200	COG2135	peptidase activity
L2Z09_10205	COG0659	secondary active sulfate transmembrane transporter activity
L2Z09_10225	COG1113	amino acid transport
L2Z09_10235	COG1522	sequence-specific DNA binding
L2Z09_10260	COG1011	Hydrolase
L2Z09_10265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z09_10275	COG2137	regulation of response to DNA damage stimulus
L2Z09_10290	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z09_10325	COG0575	Belongs to the CDS family
L2Z09_10330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z09_10350	COG3852	Histidine kinase
L2Z09_10355	COG2204	response regulator
L2Z09_10410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z09_10415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z09_10435	COG0697	spore germination
L2Z09_10440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z09_10450	COG0303	'Molybdopterin
L2Z09_10455	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z09_10455	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z09_10470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z09_10475	COG0243	molybdopterin cofactor binding
L2Z09_10485	COG0243	molybdopterin cofactor binding
L2Z09_10490	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z09_10495	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z09_10495	COG2146	nitrite reductase [NAD(P)H] activity
L2Z09_10505	COG0745	RESPONSE REGULATOR receiver
L2Z09_10510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z09_10510	COG1116	anion transmembrane transporter activity
L2Z09_10530	COG0511	ligase activity, forming carbon-carbon bonds
L2Z09_10545	COG2814	Major facilitator Superfamily
L2Z09_10565	COG0069	glutamate synthase activity
L2Z09_10585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z09_10595	COG1454	alcohol dehydrogenase
L2Z09_10600	COG0824	Thioesterase
L2Z09_10610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z09_10625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z09_10630	COG2030	dehydratase
L2Z09_10640	COG0183	Belongs to the thiolase family
L2Z09_10650	COG0583	DNA-binding transcription factor activity
L2Z09_10655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z09_10665	COG1522	sequence-specific DNA binding
L2Z09_10670	COG3135	benzoate transporter
L2Z09_10680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z09_10705	COG0589	response to stress
L2Z09_10710	COG0488	(ABC) transporter
L2Z09_10730	COG4773	Receptor
L2Z09_10760	COG0668	transmembrane transport
L2Z09_10770	COG1309	transcriptional regulator
L2Z09_10780	COG2801	Transposase and inactivated derivatives
L2Z09_10795	COG1605	Chorismate mutase
L2Z09_10805	COG4221	oxidoreductase activity
L2Z09_10815	COG0308	aminopeptidase N
L2Z09_10835	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z09_10845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z09_10850	COG1454	alcohol dehydrogenase
L2Z09_10870	COG0531	amino acid
L2Z09_10875	COG4303	Ethanolamine ammonia lyase large subunit
L2Z09_10880	COG4302	ethanolamine ammonia-lyase activity
L2Z09_10885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z09_10885	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z09_10890	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z09_10900	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z09_10915	COG0697	spore germination
L2Z09_10920	COG1923	regulation of RNA biosynthetic process
L2Z09_10930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z09_10935	COG0802	atpase or kinase
L2Z09_10955	COG1187	pseudouridine synthase activity
L2Z09_10970	COG0583	DNA-binding transcription factor activity
L2Z09_10985	COG2814	Major facilitator Superfamily
L2Z09_10990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z09_11015	COG0729	surface antigen
L2Z09_11035	COG0174	glutamine synthetase
L2Z09_11040	COG0745	RESPONSE REGULATOR receiver
L2Z09_11045	COG2205	protein histidine kinase activity
L2Z09_11055	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z09_11060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z09_11085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z09_11090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z09_11095	COG1960	acyl-CoA dehydrogenase activity
L2Z09_11110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z09_11115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z09_11135	COG0583	DNA-binding transcription factor activity
L2Z09_11150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z09_11160	COG3658	cytochrome
L2Z09_11165	COG1215	transferase activity, transferring glycosyl groups
L2Z09_11170	COG0726	polysaccharide deacetylase
L2Z09_11170	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z09_11195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z09_11200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z09_11210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z09_11235	COG0305	Participates in initiation and elongation during chromosome replication
L2Z09_11240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z09_11250	COG1305	Transglutaminase-like
L2Z09_11260	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z09_11290	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z09_11295	COG0138	bifunctional purine biosynthesis protein purh
L2Z09_11300	COG0151	Belongs to the GarS family
L2Z09_11305	COG1464	Belongs to the NlpA lipoprotein family
L2Z09_11310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z09_11315	COG2011	ABC-type metal ion transport system permease component
L2Z09_11320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z09_11330	COG1301	dicarboxylic acid transport
L2Z09_11360	COG1794	racemase activity, acting on amino acids and derivatives
L2Z09_11370	COG3008	intermembrane lipid transfer
L2Z09_11370	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z09_11375	COG2995	paraquat-inducible protein a
L2Z09_11385	COG2985	domain, Protein
L2Z09_11415	COG0477	Major facilitator Superfamily
L2Z09_11465	COG2186	Transcriptional regulator
L2Z09_11475	COG0786	glutamate:sodium symporter activity
L2Z09_11480	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z09_11510	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z09_11620	COG1610	YqeY-like protein
L2Z09_11625	COG4783	chaperone-mediated protein folding
L2Z09_11650	COG1286	toxin biosynthetic process
L2Z09_11680	COG0778	Nitroreductase
L2Z09_11690	COG0513	Belongs to the DEAD box helicase family
L2Z09_11715	COG2363	Small membrane protein
L2Z09_11745	COG1234	tRNA 3'-trailer cleavage
L2Z09_11750	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z09_11760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z09_11770	COG2819	hydrolase of the alpha beta superfamily
L2Z09_11775	COG1960	acyl-CoA dehydrogenase activity
L2Z09_11780	COG1301	dicarboxylic acid transport
L2Z09_11785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z09_11790	COG3139	Protein of unknown function (DUF1315)
L2Z09_11795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z09_11800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z09_11810	COG0494	nUDIX hydrolase
L2Z09_11820	COG0642	Histidine kinase
L2Z09_11835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z09_11845	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z09_11860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z09_11865	COG0826	peptidase U32
L2Z09_11870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z09_11880	COG4598	ABC transporter
L2Z09_11885	COG4160	amino acid transport
L2Z09_11890	COG4215	(ABC) transporter
L2Z09_11905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z09_12055	COG0582	viral genome integration into host DNA
L2Z09_12060	COG1131	(ABC) transporter
L2Z09_12065	COG0842	Transport permease protein
L2Z09_12080	COG0772	Belongs to the SEDS family
L2Z09_12085	COG2951	lytic endotransglycosylase activity
L2Z09_12110	COG2207	Transcriptional regulator
L2Z09_12125	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z09_12130	COG0024	Methionine aminopeptidase
L2Z09_12140	COG2223	nitrite transmembrane transporter activity
L2Z09_12150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z09_12155	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z09_12160	COG1960	acyl-CoA dehydrogenase activity
L2Z09_12175	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z09_12180	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z09_12185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z09_12205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z09_12210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z09_12215	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z09_12250	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z09_12260	COG0174	glutamine synthetase
L2Z09_12275	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z09_12280	COG0308	aminopeptidase N
L2Z09_12310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z09_12320	COG0302	gtp cyclohydrolase
L2Z09_12345	COG3739	integral membrane protein
L2Z09_12360	COG1169	isochorismate synthase
L2Z09_12370	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z09_12375	COG1132	(ABC) transporter
L2Z09_12380	COG1132	(ABC) transporter
L2Z09_12390	COG3433	isochorismatase activity
L2Z09_12390	COG1535	isochorismatase
L2Z09_12395	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z09_12400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z09_12410	COG4774	siderophore transport
L2Z09_12415	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z09_12420	COG4604	ABC transporter, ATP-binding protein
L2Z09_12425	COG4605	iron ion homeostasis
L2Z09_12430	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z09_12435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z09_12450	COG2964	Protein conserved in bacteria
L2Z09_12460	COG1741	Belongs to the pirin family
L2Z09_12480	COG1309	transcriptional regulator
L2Z09_12490	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z09_12495	COG2814	Major facilitator Superfamily
L2Z09_12530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z09_12530	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z09_12535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z09_12545	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_12555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z09_12560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z09_12565	COG0583	DNA-binding transcription factor activity
L2Z09_12570	COG1113	amino acid transport
L2Z09_12590	COG2508	Transcriptional regulator
L2Z09_12590	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z09_12625	COG2879	small protein
L2Z09_12630	COG1966	Carbon starvation protein
L2Z09_12675	COG1067	ATP-dependent peptidase activity
L2Z09_12680	COG0583	DNA-binding transcription factor activity
L2Z09_12705	COG1686	Belongs to the peptidase S11 family
L2Z09_12710	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z09_12745	COG0616	signal peptide processing
L2Z09_12750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z09_12760	COG0573	inorganic phosphate transmembrane transporter activity
L2Z09_12765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z09_12770	COG1113	amino acid transport
L2Z09_12775	COG3961	Belongs to the TPP enzyme family
L2Z09_12780	COG1522	sequence-specific DNA binding
L2Z09_12790	COG0076	glutamate decarboxylase activity
L2Z09_12795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z09_12805	COG1309	transcriptional regulator
L2Z09_12820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z09_12855	COG0352	thiamine-phosphate diphosphorylase activity
L2Z09_12880	COG0612	Peptidase, M16
L2Z09_12890	COG1823	symporter activity
L2Z09_12900	COG0477	Major facilitator Superfamily
L2Z09_12925	COG1187	pseudouridine synthase activity
L2Z09_12940	COG1686	Belongs to the peptidase S11 family
L2Z09_12945	COG1252	NADH dehydrogenase
L2Z09_12955	COG0415	Belongs to the DNA photolyase family
L2Z09_12970	COG1215	transferase activity, transferring glycosyl groups
L2Z09_13000	COG2070	2-Nitropropane dioxygenase
L2Z09_13190	COG5410	chromosome segregation
L2Z09_13395	COG0556	nucleotide-excision repair
L2Z09_13415	COG0436	Aminotransferase
L2Z09_13445	COG4221	oxidoreductase activity
L2Z09_13455	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z09_13460	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z09_13470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z09_13485	COG0681	Belongs to the peptidase S26 family
L2Z09_13500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z09_13520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z09_13525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z09_13530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z09_13540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z09_13545	COG4208	sulfate ABC transporter
L2Z09_13550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z09_13555	COG0583	DNA-binding transcription factor activity
L2Z09_13560	COG4625	pathogenesis
L2Z09_13575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z09_13590	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z09_13600	COG1056	cytidyltransferase-related domain
L2Z09_13600	COG1051	belongs to the nudix hydrolase family
L2Z09_13605	COG1024	Enoyl-CoA hydratase
L2Z09_13615	COG2814	Major facilitator Superfamily
L2Z09_13620	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z09_13620	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z09_13640	COG1473	amidohydrolase
L2Z09_13645	COG0824	Thioesterase
L2Z09_13665	COG0823	Involved in the tonB-independent uptake of proteins
L2Z09_13685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z09_13720	COG0628	permease
L2Z09_13730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z09_13735	COG0596	Alpha beta hydrolase
L2Z09_13740	COG0616	signal peptide processing
L2Z09_13740	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z09_13750	COG0658	competence protein
L2Z09_13750	COG2333	competence protein COMEC
L2Z09_13755	COG1136	(ABC) transporter
L2Z09_13760	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z09_13795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z09_13815	COG0463	Glycosyl transferase, family 2
L2Z09_13845	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z09_13850	COG1280	lysine exporter protein (LysE YggA)
L2Z09_13860	COG0019	diaminopimelate decarboxylase activity
L2Z09_13870	COG1113	amino acid transport
L2Z09_13885	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z09_13895	COG3339	Conserved Protein
L2Z09_13900	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z09_13905	COG0243	molybdopterin cofactor binding
L2Z09_13910	COG1929	Belongs to the glycerate kinase type-1 family
L2Z09_13925	COG0778	Nitroreductase
L2Z09_13955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z09_13970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z09_14015	COG0589	response to stress
L2Z09_14020	COG0659	secondary active sulfate transmembrane transporter activity
L2Z09_14030	COG1002	Type II restriction enzyme, methylase subunits
L2Z09_14035	COG1061	Type III restriction enzyme res subunit
L2Z09_14075	COG0741	lytic transglycosylase activity
L2Z09_14095	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z09_14105	COG2826	transposase and inactivated derivatives, IS30 family
L2Z09_14135	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z09_14140	COG1597	lipid kinase activity
L2Z09_14155	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z09_14160	COG0477	Major facilitator Superfamily
L2Z09_14210	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z09_14215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z09_14240	COG0505	Belongs to the CarA family
L2Z09_14260	COG0589	response to stress
L2Z09_14275	COG2843	Capsule synthesis protein
L2Z09_14295	COG2321	neutral zinc metallopeptidase
L2Z09_14300	COG2354	Protein conserved in bacteria
L2Z09_14320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z09_14345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z09_14350	COG1053	succinate dehydrogenase
L2Z09_14355	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z09_14360	COG2009	succinate dehydrogenase
L2Z09_14400	COG2921	Belongs to the UPF0250 family
L2Z09_14405	COG0321	lipoyl(octanoyl) transferase activity
L2Z09_14420	COG0531	amino acid
L2Z09_14430	COG1733	regulation of RNA biosynthetic process
L2Z09_14435	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z09_14440	COG1648	precorrin-2 dehydrogenase activity
L2Z09_14440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z09_14455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z09_14485	COG0671	phosphoesterase, PA-phosphatase related
L2Z09_14490	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z09_14500	COG1538	Outer membrane efflux protein
L2Z09_14505	COG0393	Putative heavy-metal-binding
L2Z09_14510	COG0393	Putative heavy-metal-binding
L2Z09_14520	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_14530	COG0525	valine-tRNA ligase activity
L2Z09_14550	COG0583	DNA-binding transcription factor activity
L2Z09_14555	COG0004	ammonium transporteR
L2Z09_14565	COG0642	Histidine kinase
L2Z09_14570	COG0745	RESPONSE REGULATOR receiver
L2Z09_14575	COG2194	sulfuric ester hydrolase activity
L2Z09_14595	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z09_14610	COG2315	Protein conserved in bacteria
L2Z09_14615	COG0142	geranyltranstransferase activity
L2Z09_14620	COG2828	Protein conserved in bacteria
L2Z09_14625	COG1113	amino acid transport
L2Z09_14645	COG2207	Transcriptional regulator
L2Z09_14670	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z09_14680	COG0560	Phosphoserine phosphatase
L2Z09_14690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z09_14700	COG1530	ribonuclease E activity
L2Z09_14705	COG0424	maF-like protein
L2Z09_14710	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z09_14715	COG1792	Involved in formation and maintenance of cell shape
L2Z09_14720	COG1077	Cell shape determining protein MreB Mrl
L2Z09_14725	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z09_14735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z09_14770	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z09_14775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z09_14780	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z09_14785	COG1115	amino acid carrier protein
L2Z09_14805	COG2814	Major facilitator Superfamily
L2Z09_14810	COG1289	transmembrane transporter activity
L2Z09_14820	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z09_14860	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z09_14865	COG2832	Protein of unknown function (DUF454)
L2Z09_14875	COG5510	response to toxic substance
L2Z09_14895	COG0840	transmembrane signaling receptor activity
L2Z09_14935	COG3422	double-strand break repair
L2Z09_14940	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z09_14945	COG3189	MarR family transcriptional regulator
L2Z09_14955	COG0354	folic acid binding
L2Z09_14960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z09_14970	COG0679	Auxin Efflux Carrier
L2Z09_14975	COG1902	pentaerythritol trinitrate reductase activity
L2Z09_14980	COG4772	TonB-dependent receptor
L2Z09_14985	COG2094	Belongs to the DNA glycosylase MPG family
L2Z09_15010	COG1217	gtp-binding protein TYPA
L2Z09_15015	COG2233	PERMEase
L2Z09_15025	COG0833	amino acid
L2Z09_15030	COG1690	Belongs to the RtcB family
L2Z09_15040	COG2885	chlorophyll binding
L2Z09_15040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z09_15050	COG0183	Belongs to the thiolase family
L2Z09_15070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z09_15090	COG2207	Transcriptional regulator
L2Z09_15095	COG0183	Belongs to the thiolase family
L2Z09_15125	COG1272	protein, Hemolysin III
L2Z09_15130	COG0477	Major facilitator Superfamily
L2Z09_15145	COG0450	alkyl hydroperoxide reductase
L2Z09_15165	COG0285	dihydrofolate synthase activity
L2Z09_15215	COG2096	Adenosyltransferase
L2Z09_15235	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z09_15240	COG0745	RESPONSE REGULATOR receiver
L2Z09_15245	COG2205	protein histidine kinase activity
L2Z09_15255	COG1960	acyl-CoA dehydrogenase activity
L2Z09_15260	COG1960	acyl-CoA dehydrogenase activity
L2Z09_15265	COG0583	DNA-binding transcription factor activity
L2Z09_15270	COG0625	glutathione transferase activity
L2Z09_15335	COG0438	transferase activity, transferring glycosyl groups
L2Z09_15340	COG0463	Glycosyl transferase, family 2
L2Z09_15345	COG0726	polysaccharide deacetylase
L2Z09_15365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z09_15370	COG2205	protein histidine kinase activity
L2Z09_15425	COG1862	Preprotein translocase
L2Z09_15435	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z09_15440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z09_15450	COG3781	membrane
L2Z09_15455	COG0613	PHP domain protein
L2Z09_15465	COG2350	Protein conserved in bacteria
L2Z09_15495	COG1607	acyl-coa hydrolase
L2Z09_15555	COG2199	diguanylate cyclase activity
L2Z09_15565	COG1408	metallophosphoesterase
L2Z09_15570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z09_15580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z09_15600	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z09_15605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z09_15620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z09_15630	COG2969	positive regulation of protein catabolic process
L2Z09_15650	COG1960	acyl-CoA dehydrogenase activity
L2Z09_15655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z09_15670	COG1309	transcriptional regulator
L2Z09_15675	COG1960	acyl-CoA dehydrogenase activity
L2Z09_15720	COG1183	phosphatidylcholine synthase activity
L2Z09_15725	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z09_15755	COG1196	nuclear chromosome segregation
L2Z09_15755	COG0741	lytic transglycosylase activity
L2Z09_15755	COG0739	heme binding
L2Z09_15765	COG1702	phosphate starvation-inducible protein PhoH
L2Z09_15800	COG1295	ribonuclease BN
L2Z09_15805	COG0697	spore germination
L2Z09_15810	COG2169	Transcriptional regulator
L2Z09_15815	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z09_15860	COG0557	exoribonuclease II activity
L2Z09_15865	COG0339	signal peptide processing
L2Z09_15870	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z09_15900	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z09_15905	COG1960	acyl-CoA dehydrogenase activity
L2Z09_16060	COG0626	cystathionine gamma-synthase activity
L2Z09_16065	COG0433	COG0433 Predicted ATPase
L2Z09_16070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z09_16070	COG1017	nitric oxide dioxygenase activity
L2Z09_16075	COG1959	2 iron, 2 sulfur cluster binding
L2Z09_16090	COG1301	dicarboxylic acid transport
L2Z09_16095	COG1946	Acyl-CoA thioesterase
L2Z09_16115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z09_16120	COG1040	competence protein
L2Z09_16125	COG0494	nUDIX hydrolase
L2Z09_16135	COG0598	Magnesium transport protein CorA
L2Z09_16145	COG2854	intermembrane phospholipid transfer
L2Z09_16155	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z09_16160	COG1127	ABC transporter
L2Z09_16170	COG0513	Belongs to the DEAD box helicase family
L2Z09_16190	COG0408	coproporphyrinogen oxidase activity
L2Z09_16205	COG1960	acyl-CoA dehydrogenase activity
L2Z09_16215	COG1983	PspC domain protein
L2Z09_16220	COG0517	IMP dehydrogenase activity
L2Z09_16265	COG0583	DNA-binding transcription factor activity
L2Z09_16305	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_16315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z09_16320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z09_16325	COG0833	amino acid
L2Z09_16355	COG1192	Involved in chromosome partitioning
L2Z09_16360	COG0628	permease
L2Z09_16370	COG1289	transmembrane transporter activity
L2Z09_16385	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z09_16390	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z09_16400	COG0277	FAD linked oxidase domain protein
L2Z09_16405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z09_16430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z09_16435	COG5380	lipid catabolic process
L2Z09_16455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z09_16505	COG0194	GDP metabolic process
L2Z09_16520	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z09_16540	COG3307	-O-antigen
L2Z09_16560	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z09_16565	COG1704	LemA family
L2Z09_16575	COG0493	'glutamate synthase
L2Z09_16580	COG0067	glutamate synthase
L2Z09_16580	COG0069	glutamate synthase activity
L2Z09_16580	COG0070	glutamate synthase
L2Z09_16630	COG2226	methyltransferase
L2Z09_16645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z09_16650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z09_16695	COG0833	amino acid
L2Z09_16780	COG0488	(ABC) transporter
L2Z09_16785	COG2873	o-acetylhomoserine
L2Z09_16790	COG4221	oxidoreductase activity
L2Z09_16795	COG0659	secondary active sulfate transmembrane transporter activity
L2Z09_16820	COG0427	acetyl-CoA hydrolase
L2Z09_16850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z09_16880	COG2329	Antibiotic biosynthesis monooxygenase
L2Z09_16895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z09_16960	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z09_16965	COG1733	regulation of RNA biosynthetic process
L2Z09_17000	COG0667	Aldo Keto reductase
L2Z09_17020	COG0583	DNA-binding transcription factor activity
L2Z09_17025	COG2814	Major facilitator Superfamily
L2Z09_17055	COG1335	isochorismatase
L2Z09_17065	COG1012	belongs to the aldehyde dehydrogenase family
L2Z09_17070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z09_17080	COG1113	amino acid transport
L2Z09_17090	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z09_17105	COG2814	Major facilitator Superfamily
L2Z09_17115	COG0352	thiamine-phosphate diphosphorylase activity
L2Z09_17115	COG0351	phosphomethylpyrimidine kinase
L2Z09_17115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z09_17135	COG1309	transcriptional regulator
L2Z09_17140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z09_17160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z09_17170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z09_17175	COG3162	membrane
L2Z09_17180	COG2198	Histidine kinase
L2Z09_17180	COG2205	protein histidine kinase activity
L2Z09_17180	COG0784	Response regulator, receiver
L2Z09_17205	COG3328	transposase activity
L2Z09_17210	COG1522	sequence-specific DNA binding
L2Z09_17215	COG1335	isochorismatase
L2Z09_17220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z09_17230	COG0668	transmembrane transport
L2Z09_17235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z09_17240	COG1519	Transferase
L2Z09_17245	COG1902	pentaerythritol trinitrate reductase activity
L2Z09_17265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z09_17290	COG0426	domain, Protein
L2Z09_17290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z09_17295	COG4774	siderophore transport
L2Z09_17300	COG2119	membrane
L2Z09_17310	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z09_17320	COG4942	peptidase
L2Z09_17335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z09_17345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z09_17365	COG0189	ligase activity
L2Z09_17385	COG0708	Exodeoxyribonuclease III
L2Z09_17390	COG1393	Belongs to the ArsC family
L2Z09_17405	COG3706	GGDEF domain
L2Z09_17440	COG2351	hydroxyisourate hydrolase activity
L2Z09_17445	COG2233	PERMEase
L2Z09_17455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z09_17465	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z09_17470	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_17480	COG3150	esterase
L2Z09_17510	COG2918	glutathione biosynthetic process
L2Z09_17525	COG2733	membrane
L2Z09_17530	COG0436	Aminotransferase
L2Z09_17535	COG0534	Mate efflux family protein
L2Z09_17635	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z09_17640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z09_17650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z09_17655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z09_17670	COG0010	Belongs to the arginase family
L2Z09_17700	COG2188	Transcriptional regulator
L2Z09_17710	COG0523	cobalamin synthesis protein
L2Z09_17720	COG1113	amino acid transport
L2Z09_17730	COG0625	glutathione transferase activity
L2Z09_17750	COG1683	Conserved Protein
L2Z09_17755	COG0534	Mate efflux family protein
L2Z09_17760	COG0385	Bile acid
L2Z09_17765	COG1335	isochorismatase
L2Z09_17770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z09_17790	COG2116	formate transmembrane transporter activity
L2Z09_17795	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z09_17800	COG2133	pyrroloquinoline quinone binding
L2Z09_17805	COG2983	Belongs to the UPF0260 family
L2Z09_17825	COG1194	a g-specific adenine glycosylase
L2Z09_17840	COG2818	Glycosylase
L2Z09_17845	COG1064	alcohol dehydrogenase
L2Z09_17850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z09_17865	COG0583	DNA-binding transcription factor activity
L2Z09_17870	COG0656	L-ascorbic acid biosynthetic process
L2Z09_17875	COG2814	Major facilitator Superfamily
L2Z09_17910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z09_17925	COG2233	PERMEase
L2Z09_17930	COG0583	DNA-binding transcription factor activity
L2Z09_17965	COG0733	neurotransmitter:sodium symporter activity
L2Z09_18010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z09_18015	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z09_18020	COG0596	Alpha beta hydrolase
L2Z09_18045	COG0488	(ABC) transporter
L2Z09_18050	COG0586	Pfam SNARE associated Golgi protein
L2Z09_18060	COG0187	DNA topoisomerase II activity
L2Z09_18070	COG0592	DNA-directed DNA polymerase activity
L2Z09_18095	COG0706	membrane insertase activity
L2Z09_18110	COG1230	cation diffusion facilitator family transporter
L2Z09_18115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z09_18130	COG0402	S-adenosylhomocysteine deaminase activity
L2Z09_18140	COG0754	glutathionylspermidine amidase activity
L2Z09_18150	COG0861	Integral membrane protein TerC family
L2Z09_18155	COG0671	phosphoesterase, PA-phosphatase related
L2Z09_18165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z09_18180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z09_18185	COG2951	lytic endotransglycosylase activity
L2Z09_18215	COG0583	DNA-binding transcription factor activity
L2Z09_18235	COG0657	acetylesterase activity
L2Z09_18240	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z09_18280	COG1047	Peptidyl-prolyl cis-trans
L2Z09_18290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z09_18295	COG0196	riboflavin kinase activity
L2Z09_18305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z09_18310	COG1309	transcriptional regulator
L2Z09_18315	COG1116	anion transmembrane transporter activity
L2Z09_18320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z09_18325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z09_18330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z09_18335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z09_18355	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_18360	COG0546	phosphoglycolate phosphatase activity
L2Z09_18420	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z09_18425	COG0728	peptidoglycan biosynthetic process
L2Z09_18455	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z09_18465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2Z09_18470	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2Z09_18475	COG2089	acid synthase
L2Z09_18485	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z09_18490	COG1083	cytidylyl-transferase
L2Z09_18495	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_18505	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z09_18540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2Z09_18555	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z09_18570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z09_18585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z09_18590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z09_18600	COG2186	Transcriptional regulator
L2Z09_18610	COG0277	FAD linked oxidase domain protein
L2Z09_18615	COG1448	Aminotransferase
L2Z09_18625	COG1802	Transcriptional regulator
L2Z09_18640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z09_18680	COG2801	Transposase and inactivated derivatives
L2Z09_18735	COG0564	pseudouridine synthase activity
L2Z09_18775	COG0251	oxidation-reduction process
L2Z09_18780	COG1113	amino acid transport
L2Z09_18785	COG1113	amino acid transport
L2Z09_18805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z09_18810	COG1960	acyl-CoA dehydrogenase activity
L2Z09_18815	COG1024	Enoyl-CoA hydratase
L2Z09_18820	COG1024	Enoyl-CoA hydratase
L2Z09_18825	COG0477	Major facilitator Superfamily
L2Z09_18830	COG3916	Acyl-homoserine-lactone synthase
L2Z09_18840	COG2197	response regulator
L2Z09_18850	COG1960	acyl-CoA dehydrogenase activity
L2Z09_18855	COG3321	synthase
L2Z09_18855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z09_18855	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z09_18855	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z09_18895	COG0271	Belongs to the BolA IbaG family
L2Z09_18905	COG1192	Involved in chromosome partitioning
L2Z09_18920	COG0586	Pfam SNARE associated Golgi protein
L2Z09_18925	COG2259	Doxx family
L2Z09_18930	COG4399	Belongs to the UPF0754 family
L2Z09_18935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z09_18935	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z09_18980	COG0281	malic enzyme
L2Z09_18985	COG2837	iron assimilation
L2Z09_18990	COG1280	lysine exporter protein (LysE YggA)
L2Z09_18995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z09_19000	COG1121	(ABC) transporter
L2Z09_19070	COG0386	Belongs to the glutathione peroxidase family
L2Z09_19085	COG1309	transcriptional regulator
L2Z09_19090	COG0697	spore germination
L2Z09_19100	COG0758	DNA mediated transformation