locus-tag	class	description
L2Z16_00040	COG1047	Peptidyl-prolyl cis-trans
L2Z16_00050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z16_00055	COG0196	riboflavin kinase activity
L2Z16_00065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z16_00070	COG1309	transcriptional regulator
L2Z16_00075	COG1116	anion transmembrane transporter activity
L2Z16_00080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z16_00085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z16_00090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z16_00095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z16_00115	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_00120	COG0546	phosphoglycolate phosphatase activity
L2Z16_00175	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z16_00180	COG0728	peptidoglycan biosynthetic process
L2Z16_00210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z16_00240	COG0438	transferase activity, transferring glycosyl groups
L2Z16_00265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z16_00270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z16_00285	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z16_00290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z16_00300	COG2186	Transcriptional regulator
L2Z16_00310	COG0277	FAD linked oxidase domain protein
L2Z16_00315	COG1448	Aminotransferase
L2Z16_00325	COG1802	Transcriptional regulator
L2Z16_00340	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z16_00400	COG0564	pseudouridine synthase activity
L2Z16_00440	COG0251	oxidation-reduction process
L2Z16_00445	COG1113	amino acid transport
L2Z16_00450	COG1113	amino acid transport
L2Z16_00470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z16_00475	COG1960	acyl-CoA dehydrogenase activity
L2Z16_00480	COG1024	Enoyl-CoA hydratase
L2Z16_00485	COG1024	Enoyl-CoA hydratase
L2Z16_00490	COG0477	Major facilitator Superfamily
L2Z16_00495	COG3916	Acyl-homoserine-lactone synthase
L2Z16_00505	COG2197	response regulator
L2Z16_00515	COG1960	acyl-CoA dehydrogenase activity
L2Z16_00520	COG3321	synthase
L2Z16_00520	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z16_00520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z16_00520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z16_00540	COG2267	carboxylic ester hydrolase activity
L2Z16_00560	COG0271	Belongs to the BolA IbaG family
L2Z16_00570	COG1192	Involved in chromosome partitioning
L2Z16_00585	COG0586	Pfam SNARE associated Golgi protein
L2Z16_00590	COG2259	Doxx family
L2Z16_00595	COG4399	Belongs to the UPF0754 family
L2Z16_00600	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z16_00600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z16_00645	COG0281	malic enzyme
L2Z16_00655	COG2837	iron assimilation
L2Z16_00660	COG1280	lysine exporter protein (LysE YggA)
L2Z16_00665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z16_00670	COG1121	(ABC) transporter
L2Z16_00735	COG0386	Belongs to the glutathione peroxidase family
L2Z16_00750	COG1309	transcriptional regulator
L2Z16_00755	COG0697	spore germination
L2Z16_00765	COG0758	DNA mediated transformation
L2Z16_00835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z16_00845	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z16_00885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z16_00905	COG1253	flavin adenine dinucleotide binding
L2Z16_00915	COG2860	membrane
L2Z16_00920	COG0477	Major facilitator Superfamily
L2Z16_00930	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z16_00945	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z16_00965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z16_01010	COG0589	response to stress
L2Z16_01015	COG0659	secondary active sulfate transmembrane transporter activity
L2Z16_01025	COG1002	Type II restriction enzyme, methylase subunits
L2Z16_01030	COG1061	Type III restriction enzyme res subunit
L2Z16_01105	COG0347	Belongs to the P(II) protein family
L2Z16_01110	COG0004	ammonium transporteR
L2Z16_01120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z16_01120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z16_01160	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z16_01165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z16_01170	COG0793	Belongs to the peptidase S41A family
L2Z16_01185	COG2197	response regulator
L2Z16_01195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z16_01205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z16_01210	COG4974	Belongs to the 'phage' integrase family
L2Z16_01235	COG0772	Belongs to the SEDS family
L2Z16_01240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z16_01245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z16_01250	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z16_01275	COG0697	spore germination
L2Z16_01280	COG1538	Outer membrane efflux protein
L2Z16_01300	COG3275	phosphorelay sensor kinase activity
L2Z16_01310	COG0181	hydroxymethylbilane synthase activity
L2Z16_01355	COG1716	ATPase activity
L2Z16_01360	COG0546	phosphoglycolate phosphatase activity
L2Z16_01455	COG0596	Alpha beta hydrolase
L2Z16_01460	COG2056	Na+-H+ antiporter family
L2Z16_01475	COG0326	Molecular chaperone. Has ATPase activity
L2Z16_01490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z16_01555	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z16_01560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z16_01560	COG2169	Transcriptional regulator
L2Z16_01590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z16_01600	COG0497	DNA recombination
L2Z16_01615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z16_01625	COG0237	dephospho-CoA kinase activity
L2Z16_01630	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z16_01680	COG0195	Participates in both transcription termination and antitermination
L2Z16_01695	COG1320	monovalent cation:proton antiporter activity
L2Z16_01700	COG2212	antiporter activity
L2Z16_01705	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z16_01710	COG0651	ATP synthesis coupled electron transport
L2Z16_01715	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z16_01720	COG2111	Na H antiporter
L2Z16_01720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z16_01735	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z16_01740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z16_01755	COG2226	methyltransferase
L2Z16_01775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z16_01780	COG1074	ATP-dependent DNA helicase activity
L2Z16_01785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z16_01790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z16_01805	COG0598	Magnesium transport protein CorA
L2Z16_01810	COG0789	Transcriptional regulator
L2Z16_01815	COG0484	heat shock protein binding
L2Z16_01825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z16_01830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z16_01830	COG0475	glutathione-regulated potassium exporter activity
L2Z16_01835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z16_01855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z16_01865	COG4535	Mg2 and Co2 transporter CorC
L2Z16_01870	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z16_01875	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z16_01875	COG0644	oxidoreductase
L2Z16_01885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z16_01900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z16_01905	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z16_01945	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z16_01960	COG0534	Mate efflux family protein
L2Z16_01970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z16_01975	COG4221	oxidoreductase activity
L2Z16_01980	COG0583	DNA-binding transcription factor activity
L2Z16_01995	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z16_02000	COG1530	ribonuclease E activity
L2Z16_02010	COG0546	phosphoglycolate phosphatase activity
L2Z16_02015	COG2378	regulation of single-species biofilm formation
L2Z16_02020	COG0625	glutathione transferase activity
L2Z16_02030	COG0583	DNA-binding transcription factor activity
L2Z16_02095	COG0473	3-isopropylmalate dehydrogenase activity
L2Z16_02150	COG1301	dicarboxylic acid transport
L2Z16_02160	COG1560	Kdo2-lipid A biosynthetic process
L2Z16_02165	COG1280	lysine exporter protein (LysE YggA)
L2Z16_02170	COG0488	(ABC) transporter
L2Z16_02175	COG2900	Belongs to the SlyX family
L2Z16_02185	COG1733	regulation of RNA biosynthetic process
L2Z16_02210	COG0210	DNA helicase
L2Z16_02215	COG0724	RNA recognition motif
L2Z16_02235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z16_02235	COG4651	solute:proton antiporter activity
L2Z16_02260	COG0788	formyltetrahydrofolate deformylase activity
L2Z16_02360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z16_02360	COG2813	Specifically methylates the guanine in position
L2Z16_02370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z16_02380	COG4774	siderophore transport
L2Z16_02390	COG0740	serine-type endopeptidase activity
L2Z16_02410	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z16_02410	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z16_02415	COG0857	belongs to the CobB CobQ family
L2Z16_02415	COG0280	phosphate acetyltransferase
L2Z16_02420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z16_02435	COG0800	Aldolase
L2Z16_02445	COG3265	gluconokinase activity
L2Z16_02450	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_02460	COG2267	carboxylic ester hydrolase activity
L2Z16_02475	COG0793	Belongs to the peptidase S41A family
L2Z16_02510	COG1426	Protein conserved in bacteria
L2Z16_02555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z16_02565	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z16_02580	COG2986	histidine ammonia-lyase
L2Z16_02620	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_02625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z16_02645	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z16_02655	COG1162	GTPase activity
L2Z16_02660	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z16_02675	COG1538	Outer membrane efflux protein
L2Z16_02680	COG0577	efflux transmembrane transporter activity
L2Z16_02680	COG1136	(ABC) transporter
L2Z16_02685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z16_02710	COG0028	Belongs to the TPP enzyme family
L2Z16_02715	COG0440	acetolactate synthase activity
L2Z16_02745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z16_02760	COG0084	hydrolase, TatD family'
L2Z16_02775	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z16_02785	COG0583	DNA-binding transcription factor activity
L2Z16_02795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z16_02800	COG2814	Major facilitator Superfamily
L2Z16_02810	COG0697	spore germination
L2Z16_02840	COG3622	Belongs to the hyi family
L2Z16_02845	COG2084	Dehydrogenase
L2Z16_02850	COG1024	Enoyl-CoA hydratase
L2Z16_02860	COG0784	Response regulator, receiver
L2Z16_02860	COG5002	protein histidine kinase activity
L2Z16_02860	COG2205	protein histidine kinase activity
L2Z16_02880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z16_02890	COG3956	TIGRFAM MazG family protein
L2Z16_02895	COG1555	photosystem II stabilization
L2Z16_02900	COG0617	tRNA 3'-terminal CCA addition
L2Z16_02905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z16_02925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z16_02930	COG3028	Belongs to the UPF0307 family
L2Z16_02935	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z16_02950	COG0625	glutathione transferase activity
L2Z16_02955	COG1238	metal cluster binding
L2Z16_03000	COG0072	phenylalanine-tRNA ligase activity
L2Z16_03030	COG0248	Ppx GppA phosphatase
L2Z16_03040	COG0037	tRNA processing
L2Z16_03090	COG1764	response to oxidative stress
L2Z16_03095	COG1846	Transcriptional regulator
L2Z16_03105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z16_03165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z16_03170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z16_03175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z16_03185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z16_03240	COG1214	PFAM Peptidase M22, glycoprotease
L2Z16_03265	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z16_03270	COG0561	phosphatase activity
L2Z16_03280	COG2132	Multicopper oxidase
L2Z16_03285	COG3667	copper resistance
L2Z16_03300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z16_03305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z16_03310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z16_03340	COG1063	alcohol dehydrogenase
L2Z16_03345	COG0583	DNA-binding transcription factor activity
L2Z16_03350	COG1960	acyl-CoA dehydrogenase activity
L2Z16_03355	COG2814	Major facilitator Superfamily
L2Z16_03360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z16_03370	COG1053	succinate dehydrogenase
L2Z16_03375	COG0583	DNA-binding transcription factor activity
L2Z16_03390	COG0583	DNA-binding transcription factor activity
L2Z16_03420	COG0583	DNA-binding transcription factor activity
L2Z16_03435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z16_03460	COG0384	phenazine biosynthesis protein PhzF
L2Z16_03485	COG4993	Dehydrogenase
L2Z16_03555	COG2205	protein histidine kinase activity
L2Z16_03565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z16_03585	COG0745	RESPONSE REGULATOR receiver
L2Z16_03625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z16_03655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z16_03660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z16_03680	COG0583	DNA-binding transcription factor activity
L2Z16_03700	COG0668	transmembrane transport
L2Z16_03710	COG2081	HI0933 family
L2Z16_03715	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z16_03745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z16_03745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z16_03755	COG0489	protein tyrosine kinase activity
L2Z16_03805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z16_03815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z16_03830	COG0730	response to heat
L2Z16_03840	COG1196	nuclear chromosome segregation
L2Z16_03860	COG2223	nitrite transmembrane transporter activity
L2Z16_03865	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z16_03870	COG1877	trehalose-phosphatase activity
L2Z16_03875	COG0596	Alpha beta hydrolase
L2Z16_03875	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z16_03875	COG2226	methyltransferase
L2Z16_03890	COG4106	trans-aconitate 2-methyltransferase activity
L2Z16_03905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z16_03910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z16_03915	COG0009	L-threonylcarbamoyladenylate synthase
L2Z16_03920	COG3101	peptidyl-lysine hydroxylation
L2Z16_03925	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z16_03950	COG1652	LysM domain
L2Z16_03955	COG0352	thiamine-phosphate diphosphorylase activity
L2Z16_03955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z16_03955	COG0351	phosphomethylpyrimidine kinase
L2Z16_03965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z16_03995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z16_04025	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z16_04040	COG0358	DNA primase activity
L2Z16_04050	COG0564	pseudouridine synthase activity
L2Z16_04075	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z16_04095	COG0583	DNA-binding transcription factor activity
L2Z16_04100	COG0473	3-isopropylmalate dehydrogenase activity
L2Z16_04110	COG0657	acetylesterase activity
L2Z16_04120	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_04140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z16_04140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z16_04155	COG1981	membrane
L2Z16_04200	COG0456	acetyltransferase
L2Z16_04210	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z16_04215	COG0492	ferredoxin-NADP+ reductase activity
L2Z16_04220	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z16_04220	COG1674	ftsk spoiiie
L2Z16_04225	COG1280	lysine exporter protein (LysE YggA)
L2Z16_04250	COG2894	cell division
L2Z16_04265	COG0204	Acyl-transferase
L2Z16_04270	COG2885	chlorophyll binding
L2Z16_04275	COG0210	DNA helicase
L2Z16_04285	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z16_04300	COG0121	glutamine amidotransferase
L2Z16_04320	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z16_04325	COG0735	belongs to the Fur family
L2Z16_04350	COG0420	3'-5' exonuclease activity
L2Z16_04370	COG1090	epimerase
L2Z16_04385	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z16_04395	COG2814	Major facilitator Superfamily
L2Z16_04400	COG0405	Gamma-glutamyltransferase
L2Z16_04480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z16_04570	COG1484	DNA-dependent DNA replication
L2Z16_04765	COG2026	Addiction module toxin, RelE StbE family
L2Z16_04805	COG0592	DNA-directed DNA polymerase activity
L2Z16_04910	COG0582	viral genome integration into host DNA
L2Z16_04965	COG0629	single-stranded DNA binding
L2Z16_05000	COG0084	hydrolase, TatD family'
L2Z16_05020	COG0477	Major facilitator Superfamily
L2Z16_05025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z16_05035	COG1595	DNA-templated transcription, initiation
L2Z16_05090	COG0531	amino acid
L2Z16_05095	COG2040	homocysteine
L2Z16_05120	COG1309	transcriptional regulator
L2Z16_05125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z16_05130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z16_05140	COG1607	acyl-coa hydrolase
L2Z16_05150	COG0523	cobalamin synthesis protein
L2Z16_05160	COG4681	YaeQ
L2Z16_05170	COG0726	polysaccharide deacetylase
L2Z16_05170	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z16_05175	COG1215	transferase activity, transferring glycosyl groups
L2Z16_05185	COG1024	Enoyl-CoA hydratase
L2Z16_05200	COG1414	Transcriptional regulator
L2Z16_05220	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_05230	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z16_05235	COG2271	Major facilitator Superfamily
L2Z16_05245	COG2267	carboxylic ester hydrolase activity
L2Z16_05250	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_05265	COG0028	Belongs to the TPP enzyme family
L2Z16_05275	COG0477	Major facilitator Superfamily
L2Z16_05280	COG0242	peptide deformylase activity
L2Z16_05285	COG2066	Belongs to the glutaminase family
L2Z16_05290	COG2207	Transcriptional regulator
L2Z16_05295	COG2223	nitrite transmembrane transporter activity
L2Z16_05310	COG0583	DNA-binding transcription factor activity
L2Z16_05315	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_05320	COG2271	Major facilitator Superfamily
L2Z16_05325	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z16_05330	COG3958	Transketolase
L2Z16_05340	COG0306	phosphate transporter
L2Z16_05360	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z16_05405	COG4181	ATPase activity
L2Z16_05410	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z16_05435	COG0583	DNA-binding transcription factor activity
L2Z16_05445	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z16_05450	COG1773	rubredoxin
L2Z16_05505	COG2851	Citrate transporter
L2Z16_05510	COG1253	flavin adenine dinucleotide binding
L2Z16_05550	COG0804	urea catabolic process
L2Z16_05560	COG0830	nickel cation binding
L2Z16_05575	COG0742	ribosomal rna small subunit methyltransferase
L2Z16_05580	COG0768	penicillin binding
L2Z16_05605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z16_05610	COG2878	Part of a membrane complex involved in electron transport
L2Z16_05615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z16_05625	COG3384	dioxygenase
L2Z16_05650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z16_05980	COG0739	heme binding
L2Z16_06065	COG0006	proline dipeptidase activity
L2Z16_06070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z16_06075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z16_06095	COG1279	arginine transmembrane transporter activity
L2Z16_06100	COG0583	DNA-binding transcription factor activity
L2Z16_06140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z16_06145	COG0741	lytic transglycosylase activity
L2Z16_06145	COG1388	LysM domain
L2Z16_06145	COG0741	lytic transglycosylase activity
L2Z16_06145	COG1388	LysM domain
L2Z16_06155	COG4174	ABC transporter (Permease)
L2Z16_06160	COG4239	(ABC) transporter, permease
L2Z16_06165	COG4172	Belongs to the ABC transporter superfamily
L2Z16_06185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z16_06195	COG2203	Gaf domain
L2Z16_06195	COG3706	GGDEF domain
L2Z16_06195	COG4251	negative regulation of phosphorylation
L2Z16_06195	COG5001	Diguanylate cyclase
L2Z16_06205	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z16_06205	COG1902	pentaerythritol trinitrate reductase activity
L2Z16_06245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2Z16_06270	COG1309	transcriptional regulator
L2Z16_06275	COG1741	Belongs to the pirin family
L2Z16_06290	COG2072	flavoprotein involved in K transport
L2Z16_06300	COG2252	PERMEase
L2Z16_06305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z16_06310	COG3038	cytochrome b561
L2Z16_06320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z16_06330	COG0527	aspartate kinase activity
L2Z16_06340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z16_06350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z16_06365	COG0667	Aldo Keto reductase
L2Z16_06385	COG1765	OsmC-like protein
L2Z16_06400	COG0542	response to heat
L2Z16_06435	COG2885	chlorophyll binding
L2Z16_06445	COG0625	glutathione transferase activity
L2Z16_06450	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z16_06470	COG3634	alkyl hydroperoxide reductase activity
L2Z16_06480	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z16_06490	COG0450	alkyl hydroperoxide reductase
L2Z16_06495	COG1643	Atp-dependent helicase
L2Z16_06510	COG2814	Major facilitator Superfamily
L2Z16_06515	COG3135	benzoate transporter
L2Z16_06520	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_06525	COG0633	Ferredoxin
L2Z16_06525	COG0543	2 iron, 2 sulfur cluster binding
L2Z16_06530	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z16_06535	COG4638	Rieske (2fe-2S)
L2Z16_06545	COG0583	DNA-binding transcription factor activity
L2Z16_06595	COG1570	exodeoxyribonuclease VII activity
L2Z16_06625	COG1280	lysine exporter protein (LysE YggA)
L2Z16_06630	COG1278	Cold shock
L2Z16_06665	COG2814	Major facilitator Superfamily
L2Z16_06700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z16_06700	COG0517	IMP dehydrogenase activity
L2Z16_06705	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z16_06715	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z16_06720	COG1137	ATPase activity
L2Z16_06725	COG1538	Outer membrane efflux protein
L2Z16_06755	COG4122	O-methyltransferase activity
L2Z16_06765	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z16_06780	COG1522	sequence-specific DNA binding
L2Z16_06785	COG5006	permease, DMT superfamily
L2Z16_06795	COG1560	Kdo2-lipid A biosynthetic process
L2Z16_06810	COG2814	Major facilitator Superfamily
L2Z16_06830	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z16_06880	COG0583	DNA-binding transcription factor activity
L2Z16_06885	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z16_06905	COG4770	biotin carboxylase activity
L2Z16_06910	COG0038	chloride channel
L2Z16_06930	COG1309	transcriptional regulator
L2Z16_06940	COG1063	alcohol dehydrogenase
L2Z16_06955	COG0439	Biotin carboxylase
L2Z16_06960	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z16_06980	COG0864	Transcriptional regulator
L2Z16_06990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z16_06995	COG1116	anion transmembrane transporter activity
L2Z16_07115	COG0590	tRNA wobble adenosine to inosine editing
L2Z16_07120	COG2807	transmembrane transport
L2Z16_07135	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z16_07150	COG0789	Transcriptional regulator
L2Z16_07160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z16_07180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z16_07190	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z16_07205	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_07210	COG0531	amino acid
L2Z16_07215	COG1760	l-serine dehydratase
L2Z16_07220	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_07220	COG2030	dehydratase
L2Z16_07225	COG3396	Phenylacetate-CoA oxygenase
L2Z16_07230	COG3460	Phenylacetate-CoA oxygenase
L2Z16_07235	COG3396	Phenylacetate-CoA oxygenase
L2Z16_07240	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z16_07245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z16_07250	COG1024	Enoyl-CoA hydratase
L2Z16_07255	COG1024	Enoyl-CoA hydratase
L2Z16_07260	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z16_07265	COG0183	Belongs to the thiolase family
L2Z16_07270	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z16_07275	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z16_07285	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z16_07315	COG0753	catalase activity
L2Z16_07320	COG3038	cytochrome b561
L2Z16_07340	COG2267	carboxylic ester hydrolase activity
L2Z16_07345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z16_07350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z16_07355	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_07365	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z16_07375	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_07380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z16_07385	COG0583	DNA-binding transcription factor activity
L2Z16_07395	COG1414	Transcriptional regulator
L2Z16_07400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z16_07410	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z16_07415	COG3842	ATPase activity
L2Z16_07430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z16_07435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z16_07440	COG2814	Major facilitator Superfamily
L2Z16_07445	COG1960	acyl-CoA dehydrogenase activity
L2Z16_07460	COG1024	Enoyl-CoA hydratase
L2Z16_07470	COG2814	Major facilitator Superfamily
L2Z16_07480	COG0183	Belongs to the thiolase family
L2Z16_07485	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z16_07490	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_07495	COG1024	Enoyl-CoA hydratase
L2Z16_07500	COG1960	acyl-CoA dehydrogenase activity
L2Z16_07505	COG2814	Major facilitator Superfamily
L2Z16_07510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z16_07515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z16_07525	COG2814	Major facilitator Superfamily
L2Z16_07535	COG1960	acyl-CoA dehydrogenase activity
L2Z16_07550	COG0583	DNA-binding transcription factor activity
L2Z16_07560	COG4770	biotin carboxylase activity
L2Z16_07565	COG1024	Enoyl-CoA hydratase
L2Z16_07570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z16_07575	COG1960	acyl-CoA dehydrogenase activity
L2Z16_07580	COG1309	transcriptional regulator
L2Z16_07585	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z16_07605	COG0583	DNA-binding transcription factor activity
L2Z16_07655	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_07675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z16_07695	COG2205	protein histidine kinase activity
L2Z16_07695	COG0784	Response regulator, receiver
L2Z16_07715	COG0765	amino acid transport
L2Z16_07720	COG0765	amino acid transport
L2Z16_07725	COG1126	abc transporter atp-binding protein
L2Z16_07730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z16_07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z16_07750	COG1280	lysine exporter protein (LysE YggA)
L2Z16_07760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z16_07765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z16_07770	COG1045	serine acetyltransferase
L2Z16_07785	COG0583	DNA-binding transcription factor activity
L2Z16_07790	COG0625	glutathione transferase activity
L2Z16_07795	COG0625	glutathione transferase activity
L2Z16_07800	COG0583	DNA-binding transcription factor activity
L2Z16_07810	COG1346	cytolysis
L2Z16_07830	COG2814	Major facilitator Superfamily
L2Z16_07840	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z16_07845	COG3052	prosthetic group binding
L2Z16_07865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z16_07885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z16_07895	COG1294	oxidase, subunit
L2Z16_07900	COG1271	oxidase subunit
L2Z16_07920	COG0477	Major facilitator Superfamily
L2Z16_07930	COG4521	taurine ABC transporter
L2Z16_07935	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z16_07940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z16_07945	COG2175	clavaminate synthase activity
L2Z16_07955	COG1953	Uracil, thiamine, allantoin
L2Z16_07965	COG0583	DNA-binding transcription factor activity
L2Z16_07975	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z16_07990	COG0640	Transcriptional regulator
L2Z16_07995	COG0798	PFAM Bile acid sodium symporter
L2Z16_08000	COG0583	DNA-binding transcription factor activity
L2Z16_08015	COG3634	alkyl hydroperoxide reductase activity
L2Z16_08055	COG0436	Aminotransferase
L2Z16_08065	COG0386	Belongs to the glutathione peroxidase family
L2Z16_08105	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z16_08130	COG0012	GTP binding
L2Z16_08135	COG2011	ABC-type metal ion transport system permease component
L2Z16_08140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z16_08150	COG1464	Belongs to the NlpA lipoprotein family
L2Z16_08180	COG0765	amino acid transport
L2Z16_08185	COG0765	amino acid transport
L2Z16_08190	COG1126	abc transporter atp-binding protein
L2Z16_08200	COG1522	sequence-specific DNA binding
L2Z16_08215	COG1309	transcriptional regulator
L2Z16_08235	COG0583	DNA-binding transcription factor activity
L2Z16_08245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z16_08255	COG0697	spore germination
L2Z16_08280	COG3121	Chaperone
L2Z16_08285	COG3539	Fimbrial protein
L2Z16_08310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z16_08310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z16_08355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z16_08365	COG2353	YceI-like domain
L2Z16_08375	COG3698	Phosphodiester glycosidase
L2Z16_08390	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z16_08395	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z16_08395	COG0506	proline dehydrogenase activity
L2Z16_08395	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z16_08405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z16_08410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z16_08430	COG1132	(ABC) transporter
L2Z16_08435	COG3122	Protein conserved in bacteria
L2Z16_08440	COG3619	membrane
L2Z16_08455	COG0640	Transcriptional regulator
L2Z16_08465	COG2850	peptidyl-arginine hydroxylation
L2Z16_08470	COG0424	maF-like protein
L2Z16_08490	COG0191	fructose-bisphosphate aldolase activity
L2Z16_08495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z16_08510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z16_08520	COG1192	Involved in chromosome partitioning
L2Z16_08525	COG1475	DNA binding
L2Z16_08530	COG0811	peptide transport
L2Z16_08540	COG1132	(ABC) transporter
L2Z16_08545	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z16_08565	COG0084	hydrolase, TatD family'
L2Z16_08630	COG0776	regulation of translation
L2Z16_08660	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z16_08665	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z16_08715	COG0339	signal peptide processing
L2Z16_08725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z16_08760	COG0702	epimerase
L2Z16_08765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z16_08785	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z16_08815	COG0316	Belongs to the HesB IscA family
L2Z16_08820	COG0822	iron-sulfur transferase activity
L2Z16_08845	COG0776	regulation of translation
L2Z16_08850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z16_08855	COG2207	Transcriptional regulator
L2Z16_08860	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z16_08865	COG1960	acyl-CoA dehydrogenase activity
L2Z16_08870	COG1960	acyl-CoA dehydrogenase activity
L2Z16_08885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z16_08905	COG4264	IucA IucC family
L2Z16_08910	COG4264	IucA IucC family
L2Z16_08950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z16_08965	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z16_08985	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z16_08990	COG0730	response to heat
L2Z16_09010	COG4773	Receptor
L2Z16_09015	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z16_09030	COG1131	(ABC) transporter
L2Z16_09035	COG0842	Transport permease protein
L2Z16_09040	COG0842	Transport permease protein
L2Z16_09095	COG2226	methyltransferase
L2Z16_09120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z16_09155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z16_09165	COG0133	tryptophan synthase activity
L2Z16_09180	COG3706	GGDEF domain
L2Z16_09195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z16_09200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z16_09205	COG0022	dehydrogenase e1 component
L2Z16_09210	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z16_09215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z16_09225	COG1063	alcohol dehydrogenase
L2Z16_09230	COG3781	membrane
L2Z16_09240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z16_09240	COG3453	Protein conserved in bacteria
L2Z16_09255	COG0730	response to heat
L2Z16_09270	COG2207	Transcriptional regulator
L2Z16_09270	COG3708	Transcriptional regulator
L2Z16_09275	COG1733	regulation of RNA biosynthetic process
L2Z16_09280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z16_09290	COG2188	Transcriptional regulator
L2Z16_09305	COG4521	taurine ABC transporter
L2Z16_09310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z16_09330	COG0477	Major facilitator Superfamily
L2Z16_09340	COG1027	Aspartate ammonia-lyase
L2Z16_09355	COG0583	DNA-binding transcription factor activity
L2Z16_09360	COG0583	DNA-binding transcription factor activity
L2Z16_09365	COG0183	Belongs to the thiolase family
L2Z16_09370	COG2031	fatty acid transporter
L2Z16_09375	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z16_09385	COG0583	DNA-binding transcription factor activity
L2Z16_09395	COG2610	gluconate transmembrane transporter activity
L2Z16_09400	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_09410	COG2207	Transcriptional regulator
L2Z16_09425	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_09450	COG0543	2 iron, 2 sulfur cluster binding
L2Z16_09450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z16_09455	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z16_09460	COG4638	Rieske (2fe-2S)
L2Z16_09470	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z16_09475	COG4149	molybdate abc transporter
L2Z16_09480	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z16_09485	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_09490	COG1535	isochorismatase
L2Z16_09490	COG3433	isochorismatase activity
L2Z16_09550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z16_09565	COG0753	catalase activity
L2Z16_09575	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z16_09605	COG3539	Fimbrial protein
L2Z16_09625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z16_09645	COG2072	flavoprotein involved in K transport
L2Z16_09655	COG1538	Outer membrane efflux protein
L2Z16_09660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z16_09665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z16_09670	COG0745	RESPONSE REGULATOR receiver
L2Z16_09675	COG2205	protein histidine kinase activity
L2Z16_09685	COG2207	Transcriptional regulator
L2Z16_09700	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_09750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z16_09870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z16_09890	COG1120	ATPase activity
L2Z16_09895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z16_09905	COG1064	alcohol dehydrogenase
L2Z16_09920	COG2207	Transcriptional regulator
L2Z16_09925	COG2084	Dehydrogenase
L2Z16_09935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z16_09940	COG0583	DNA-binding transcription factor activity
L2Z16_09950	COG0129	dihydroxy-acid dehydratase activity
L2Z16_09955	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_09970	COG1566	PFAM secretion protein HlyD family protein
L2Z16_10000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z16_10030	COG0583	DNA-binding transcription factor activity
L2Z16_10045	COG2188	Transcriptional regulator
L2Z16_10075	COG3210	domain, Protein
L2Z16_10080	COG2831	hemolysin activation secretion protein
L2Z16_10090	COG1473	amidohydrolase
L2Z16_10100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z16_10100	COG0475	glutathione-regulated potassium exporter activity
L2Z16_10110	COG0583	DNA-binding transcription factor activity
L2Z16_10115	COG1335	isochorismatase
L2Z16_10125	COG1309	transcriptional regulator
L2Z16_10155	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z16_10165	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z16_10165	COG1902	pentaerythritol trinitrate reductase activity
L2Z16_10170	COG1846	Transcriptional regulator
L2Z16_10190	COG0753	catalase activity
L2Z16_10205	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_10220	COG3162	membrane
L2Z16_10230	COG3829	transcription factor binding
L2Z16_10235	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_10240	COG1960	acyl-CoA dehydrogenase activity
L2Z16_10260	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_10280	COG2186	Transcriptional regulator
L2Z16_10290	COG0583	DNA-binding transcription factor activity
L2Z16_10295	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z16_10300	COG4829	muconolactone delta-isomerase
L2Z16_10310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z16_10315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z16_10320	COG0183	Belongs to the thiolase family
L2Z16_10325	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z16_10335	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_10345	COG3733	amine oxidase
L2Z16_10355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z16_10365	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_10375	COG4638	Rieske (2fe-2S)
L2Z16_10395	COG0154	amidase activity
L2Z16_10405	COG2814	Major facilitator Superfamily
L2Z16_10430	COG1960	acyl-CoA dehydrogenase activity
L2Z16_10435	COG0583	DNA-binding transcription factor activity
L2Z16_10440	COG1414	Transcriptional regulator
L2Z16_10455	COG2391	methyltransferase activity
L2Z16_10465	COG4993	Dehydrogenase
L2Z16_10470	COG3659	wide pore channel activity
L2Z16_10475	COG3420	alginic acid biosynthetic process
L2Z16_10480	COG0710	3-dehydroquinate dehydratase activity
L2Z16_10485	COG3485	protocatechuate 3,4-dioxygenase
L2Z16_10490	COG3485	protocatechuate 3,4-dioxygenase
L2Z16_10495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z16_10500	COG2271	Major facilitator Superfamily
L2Z16_10505	COG0596	Alpha beta hydrolase
L2Z16_10510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z16_10515	COG0183	Belongs to the thiolase family
L2Z16_10520	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z16_10525	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z16_10535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z16_10540	COG2323	membrane
L2Z16_10585	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z16_10585	COG1902	pentaerythritol trinitrate reductase activity
L2Z16_10610	COG0542	response to heat
L2Z16_10615	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z16_10645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z16_10650	COG0569	domain protein
L2Z16_10655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z16_10670	COG4774	siderophore transport
L2Z16_10675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z16_10685	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z16_10700	COG1294	oxidase, subunit
L2Z16_10705	COG4890	Cyd operon protein YbgT
L2Z16_10720	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z16_10730	COG0552	protein localization to endoplasmic reticulum
L2Z16_10755	COG0517	IMP dehydrogenase activity
L2Z16_10755	COG0516	GMP reductase activity
L2Z16_10760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z16_10765	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z16_10775	COG0583	DNA-binding transcription factor activity
L2Z16_10780	COG0024	Methionine aminopeptidase
L2Z16_10810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z16_10810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z16_10815	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z16_10820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z16_10820	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z16_10820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z16_10840	COG3300	MHYT domain
L2Z16_10840	COG5001	Diguanylate cyclase
L2Z16_10855	COG2135	peptidase activity
L2Z16_10880	COG1113	amino acid transport
L2Z16_10890	COG1522	sequence-specific DNA binding
L2Z16_10915	COG1011	Hydrolase
L2Z16_10920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z16_10930	COG2137	regulation of response to DNA damage stimulus
L2Z16_10945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z16_10980	COG0575	Belongs to the CDS family
L2Z16_10985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z16_11005	COG3852	Histidine kinase
L2Z16_11010	COG2204	response regulator
L2Z16_11075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z16_11080	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z16_11100	COG0697	spore germination
L2Z16_11105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z16_11115	COG0303	'Molybdopterin
L2Z16_11120	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z16_11120	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z16_11135	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z16_11140	COG0243	molybdopterin cofactor binding
L2Z16_11150	COG0243	molybdopterin cofactor binding
L2Z16_11155	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z16_11160	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z16_11160	COG2146	nitrite reductase [NAD(P)H] activity
L2Z16_11170	COG0745	RESPONSE REGULATOR receiver
L2Z16_11175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z16_11175	COG1116	anion transmembrane transporter activity
L2Z16_11195	COG0511	ligase activity, forming carbon-carbon bonds
L2Z16_11210	COG2814	Major facilitator Superfamily
L2Z16_11275	COG0739	heme binding
L2Z16_11395	COG5410	chromosome segregation
L2Z16_11565	COG0069	glutamate synthase activity
L2Z16_11585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z16_11595	COG1454	alcohol dehydrogenase
L2Z16_11600	COG0824	Thioesterase
L2Z16_11610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z16_11625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z16_11630	COG2030	dehydratase
L2Z16_11640	COG0183	Belongs to the thiolase family
L2Z16_11650	COG0583	DNA-binding transcription factor activity
L2Z16_11655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z16_11665	COG1522	sequence-specific DNA binding
L2Z16_11670	COG3135	benzoate transporter
L2Z16_11680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z16_11705	COG0589	response to stress
L2Z16_11710	COG0488	(ABC) transporter
L2Z16_11730	COG4773	Receptor
L2Z16_11765	COG0668	transmembrane transport
L2Z16_11775	COG1309	transcriptional regulator
L2Z16_11795	COG1605	Chorismate mutase
L2Z16_11825	COG0308	aminopeptidase N
L2Z16_11845	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z16_11855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z16_11860	COG1454	alcohol dehydrogenase
L2Z16_11880	COG0531	amino acid
L2Z16_11885	COG4303	Ethanolamine ammonia lyase large subunit
L2Z16_11890	COG4302	ethanolamine ammonia-lyase activity
L2Z16_11895	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z16_11895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z16_11900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z16_11910	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z16_11925	COG0697	spore germination
L2Z16_11930	COG1923	regulation of RNA biosynthetic process
L2Z16_11940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z16_11945	COG0802	atpase or kinase
L2Z16_11965	COG1187	pseudouridine synthase activity
L2Z16_11980	COG0583	DNA-binding transcription factor activity
L2Z16_11995	COG2814	Major facilitator Superfamily
L2Z16_12000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z16_12025	COG0729	surface antigen
L2Z16_12045	COG0174	glutamine synthetase
L2Z16_12050	COG0745	RESPONSE REGULATOR receiver
L2Z16_12055	COG2205	protein histidine kinase activity
L2Z16_12065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z16_12070	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z16_12095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z16_12100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z16_12105	COG1960	acyl-CoA dehydrogenase activity
L2Z16_12120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z16_12125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z16_12145	COG0583	DNA-binding transcription factor activity
L2Z16_12160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z16_12170	COG3658	cytochrome
L2Z16_12175	COG1215	transferase activity, transferring glycosyl groups
L2Z16_12180	COG0726	polysaccharide deacetylase
L2Z16_12180	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z16_12205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z16_12210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z16_12220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z16_12245	COG0305	Participates in initiation and elongation during chromosome replication
L2Z16_12250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z16_12260	COG1305	Transglutaminase-like
L2Z16_12270	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z16_12300	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z16_12305	COG0138	bifunctional purine biosynthesis protein purh
L2Z16_12310	COG0151	Belongs to the GarS family
L2Z16_12315	COG1464	Belongs to the NlpA lipoprotein family
L2Z16_12320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z16_12325	COG2011	ABC-type metal ion transport system permease component
L2Z16_12330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z16_12340	COG1301	dicarboxylic acid transport
L2Z16_12380	COG2433	Pfam Transposase IS66
L2Z16_12390	COG3173	Aminoglycoside phosphotransferase
L2Z16_12395	COG0488	(ABC) transporter
L2Z16_12425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z16_12425	COG3008	intermembrane lipid transfer
L2Z16_12430	COG2995	paraquat-inducible protein a
L2Z16_12440	COG2985	domain, Protein
L2Z16_12470	COG0477	Major facilitator Superfamily
L2Z16_12520	COG2186	Transcriptional regulator
L2Z16_12530	COG0786	glutamate:sodium symporter activity
L2Z16_12535	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z16_12560	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z16_12660	COG1610	YqeY-like protein
L2Z16_12665	COG4783	chaperone-mediated protein folding
L2Z16_12690	COG1286	toxin biosynthetic process
L2Z16_12720	COG0778	Nitroreductase
L2Z16_12730	COG0513	Belongs to the DEAD box helicase family
L2Z16_12755	COG2363	Small membrane protein
L2Z16_12785	COG1234	tRNA 3'-trailer cleavage
L2Z16_12790	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z16_12800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z16_12810	COG2819	hydrolase of the alpha beta superfamily
L2Z16_12815	COG1960	acyl-CoA dehydrogenase activity
L2Z16_12820	COG1301	dicarboxylic acid transport
L2Z16_12825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z16_12830	COG3139	Protein of unknown function (DUF1315)
L2Z16_12835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z16_12840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z16_12850	COG0494	nUDIX hydrolase
L2Z16_12860	COG0642	Histidine kinase
L2Z16_12875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z16_12885	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z16_12900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z16_12905	COG0826	peptidase U32
L2Z16_12910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z16_12920	COG4598	ABC transporter
L2Z16_12925	COG4160	amino acid transport
L2Z16_12930	COG4215	(ABC) transporter
L2Z16_12945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z16_12990	COG1131	(ABC) transporter
L2Z16_12995	COG0842	Transport permease protein
L2Z16_13010	COG0772	Belongs to the SEDS family
L2Z16_13015	COG2951	lytic endotransglycosylase activity
L2Z16_13040	COG2207	Transcriptional regulator
L2Z16_13055	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z16_13060	COG0024	Methionine aminopeptidase
L2Z16_13070	COG2223	nitrite transmembrane transporter activity
L2Z16_13080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z16_13085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z16_13090	COG1960	acyl-CoA dehydrogenase activity
L2Z16_13105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z16_13110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z16_13115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z16_13135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z16_13140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z16_13145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z16_13180	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z16_13190	COG0174	glutamine synthetase
L2Z16_13205	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z16_13210	COG0308	aminopeptidase N
L2Z16_13240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z16_13250	COG0302	gtp cyclohydrolase
L2Z16_13275	COG3739	integral membrane protein
L2Z16_13290	COG1169	isochorismate synthase
L2Z16_13300	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z16_13305	COG1132	(ABC) transporter
L2Z16_13310	COG1132	(ABC) transporter
L2Z16_13320	COG3433	isochorismatase activity
L2Z16_13320	COG1535	isochorismatase
L2Z16_13325	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z16_13330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z16_13340	COG4774	siderophore transport
L2Z16_13345	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z16_13350	COG4604	ABC transporter, ATP-binding protein
L2Z16_13355	COG4605	iron ion homeostasis
L2Z16_13360	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z16_13365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z16_13380	COG2964	Protein conserved in bacteria
L2Z16_13390	COG1741	Belongs to the pirin family
L2Z16_13410	COG1309	transcriptional regulator
L2Z16_13420	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z16_13425	COG2814	Major facilitator Superfamily
L2Z16_13460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z16_13460	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z16_13465	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z16_13475	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_13485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z16_13490	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z16_13495	COG0583	DNA-binding transcription factor activity
L2Z16_13500	COG1113	amino acid transport
L2Z16_13520	COG2508	Transcriptional regulator
L2Z16_13520	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z16_13555	COG2879	small protein
L2Z16_13560	COG1966	Carbon starvation protein
L2Z16_13605	COG1067	ATP-dependent peptidase activity
L2Z16_13610	COG0583	DNA-binding transcription factor activity
L2Z16_13635	COG1686	Belongs to the peptidase S11 family
L2Z16_13640	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z16_13670	COG3328	transposase activity
L2Z16_13685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z16_13695	COG0573	inorganic phosphate transmembrane transporter activity
L2Z16_13700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z16_13705	COG1113	amino acid transport
L2Z16_13710	COG3961	Belongs to the TPP enzyme family
L2Z16_13715	COG1522	sequence-specific DNA binding
L2Z16_13725	COG0076	glutamate decarboxylase activity
L2Z16_13730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z16_13740	COG1309	transcriptional regulator
L2Z16_13755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z16_13790	COG0352	thiamine-phosphate diphosphorylase activity
L2Z16_13815	COG0612	Peptidase, M16
L2Z16_13825	COG1823	symporter activity
L2Z16_13830	COG0583	DNA-binding transcription factor activity
L2Z16_13835	COG0477	Major facilitator Superfamily
L2Z16_13860	COG1187	pseudouridine synthase activity
L2Z16_13875	COG1686	Belongs to the peptidase S11 family
L2Z16_13880	COG1252	NADH dehydrogenase
L2Z16_13890	COG0415	Belongs to the DNA photolyase family
L2Z16_13905	COG1215	transferase activity, transferring glycosyl groups
L2Z16_13935	COG2070	2-Nitropropane dioxygenase
L2Z16_13990	COG0556	nucleotide-excision repair
L2Z16_14010	COG0436	Aminotransferase
L2Z16_14040	COG4221	oxidoreductase activity
L2Z16_14050	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z16_14055	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z16_14065	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z16_14080	COG0681	Belongs to the peptidase S26 family
L2Z16_14095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z16_14115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z16_14120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z16_14125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z16_14135	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z16_14140	COG4208	sulfate ABC transporter
L2Z16_14145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z16_14150	COG0583	DNA-binding transcription factor activity
L2Z16_14155	COG4625	pathogenesis
L2Z16_14170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z16_14185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z16_14195	COG1051	belongs to the nudix hydrolase family
L2Z16_14195	COG1056	cytidyltransferase-related domain
L2Z16_14200	COG1024	Enoyl-CoA hydratase
L2Z16_14210	COG2814	Major facilitator Superfamily
L2Z16_14215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z16_14215	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z16_14235	COG1473	amidohydrolase
L2Z16_14240	COG0824	Thioesterase
L2Z16_14260	COG0823	Involved in the tonB-independent uptake of proteins
L2Z16_14280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z16_14315	COG0628	permease
L2Z16_14325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z16_14330	COG0596	Alpha beta hydrolase
L2Z16_14335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z16_14335	COG0616	signal peptide processing
L2Z16_14345	COG2333	competence protein COMEC
L2Z16_14345	COG0658	competence protein
L2Z16_14350	COG1136	(ABC) transporter
L2Z16_14355	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z16_14390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z16_14410	COG0463	Glycosyl transferase, family 2
L2Z16_14440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z16_14445	COG1280	lysine exporter protein (LysE YggA)
L2Z16_14455	COG0019	diaminopimelate decarboxylase activity
L2Z16_14465	COG1113	amino acid transport
L2Z16_14480	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z16_14490	COG3339	Conserved Protein
L2Z16_14495	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z16_14500	COG0243	molybdopterin cofactor binding
L2Z16_14505	COG1929	Belongs to the glycerate kinase type-1 family
L2Z16_14520	COG0778	Nitroreductase
L2Z16_14550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z16_14565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z16_14585	COG0741	lytic transglycosylase activity
L2Z16_14605	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z16_14635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z16_14640	COG1597	lipid kinase activity
L2Z16_14655	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z16_14660	COG0477	Major facilitator Superfamily
L2Z16_14710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z16_14715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z16_14740	COG0505	Belongs to the CarA family
L2Z16_14760	COG0589	response to stress
L2Z16_14775	COG2843	Capsule synthesis protein
L2Z16_14795	COG2321	neutral zinc metallopeptidase
L2Z16_14800	COG2354	Protein conserved in bacteria
L2Z16_14820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z16_14845	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z16_14850	COG1053	succinate dehydrogenase
L2Z16_14855	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z16_14860	COG2009	succinate dehydrogenase
L2Z16_14900	COG2921	Belongs to the UPF0250 family
L2Z16_14905	COG0321	lipoyl(octanoyl) transferase activity
L2Z16_14920	COG0531	amino acid
L2Z16_14930	COG1733	regulation of RNA biosynthetic process
L2Z16_14935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z16_14940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z16_14940	COG1648	precorrin-2 dehydrogenase activity
L2Z16_14955	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z16_14985	COG0671	phosphoesterase, PA-phosphatase related
L2Z16_14990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z16_15000	COG1538	Outer membrane efflux protein
L2Z16_15005	COG0393	Putative heavy-metal-binding
L2Z16_15010	COG0393	Putative heavy-metal-binding
L2Z16_15020	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_15030	COG0525	valine-tRNA ligase activity
L2Z16_15050	COG0583	DNA-binding transcription factor activity
L2Z16_15055	COG0004	ammonium transporteR
L2Z16_15065	COG0642	Histidine kinase
L2Z16_15070	COG0745	RESPONSE REGULATOR receiver
L2Z16_15075	COG2194	sulfuric ester hydrolase activity
L2Z16_15095	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z16_15110	COG2315	Protein conserved in bacteria
L2Z16_15115	COG0142	geranyltranstransferase activity
L2Z16_15120	COG2828	Protein conserved in bacteria
L2Z16_15125	COG1113	amino acid transport
L2Z16_15145	COG2207	Transcriptional regulator
L2Z16_15170	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z16_15180	COG0560	Phosphoserine phosphatase
L2Z16_15190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z16_15200	COG1530	ribonuclease E activity
L2Z16_15205	COG0424	maF-like protein
L2Z16_15210	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z16_15215	COG1792	Involved in formation and maintenance of cell shape
L2Z16_15220	COG1077	Cell shape determining protein MreB Mrl
L2Z16_15225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z16_15235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z16_15275	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z16_15280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z16_15285	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z16_15290	COG1115	amino acid carrier protein
L2Z16_15310	COG2814	Major facilitator Superfamily
L2Z16_15315	COG1289	transmembrane transporter activity
L2Z16_15325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z16_15365	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z16_15370	COG2832	Protein of unknown function (DUF454)
L2Z16_15380	COG5510	response to toxic substance
L2Z16_15400	COG0840	transmembrane signaling receptor activity
L2Z16_15440	COG3422	double-strand break repair
L2Z16_15445	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z16_15450	COG3189	MarR family transcriptional regulator
L2Z16_15460	COG0354	folic acid binding
L2Z16_15465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z16_15490	COG1902	pentaerythritol trinitrate reductase activity
L2Z16_15510	COG2094	Belongs to the DNA glycosylase MPG family
L2Z16_15535	COG1217	gtp-binding protein TYPA
L2Z16_15540	COG2233	PERMEase
L2Z16_15550	COG0833	amino acid
L2Z16_15555	COG1690	Belongs to the RtcB family
L2Z16_15565	COG2885	chlorophyll binding
L2Z16_15565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z16_15575	COG0183	Belongs to the thiolase family
L2Z16_15595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z16_15615	COG2207	Transcriptional regulator
L2Z16_15620	COG0183	Belongs to the thiolase family
L2Z16_15650	COG1272	protein, Hemolysin III
L2Z16_15655	COG0477	Major facilitator Superfamily
L2Z16_15670	COG0450	alkyl hydroperoxide reductase
L2Z16_15690	COG0285	dihydrofolate synthase activity
L2Z16_15740	COG2096	Adenosyltransferase
L2Z16_15760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z16_15765	COG0745	RESPONSE REGULATOR receiver
L2Z16_15770	COG2205	protein histidine kinase activity
L2Z16_15780	COG1960	acyl-CoA dehydrogenase activity
L2Z16_15785	COG1960	acyl-CoA dehydrogenase activity
L2Z16_15790	COG0583	DNA-binding transcription factor activity
L2Z16_15795	COG0625	glutathione transferase activity
L2Z16_15860	COG0438	transferase activity, transferring glycosyl groups
L2Z16_15865	COG0463	Glycosyl transferase, family 2
L2Z16_15870	COG0726	polysaccharide deacetylase
L2Z16_15890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z16_15895	COG2205	protein histidine kinase activity
L2Z16_15925	COG1862	Preprotein translocase
L2Z16_15935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z16_15940	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z16_15950	COG3781	membrane
L2Z16_15955	COG0613	PHP domain protein
L2Z16_15965	COG2350	Protein conserved in bacteria
L2Z16_15995	COG1607	acyl-coa hydrolase
L2Z16_16055	COG2199	diguanylate cyclase activity
L2Z16_16065	COG1408	metallophosphoesterase
L2Z16_16070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z16_16080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z16_16100	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z16_16105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z16_16120	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z16_16130	COG2969	positive regulation of protein catabolic process
L2Z16_16150	COG1960	acyl-CoA dehydrogenase activity
L2Z16_16155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z16_16170	COG1309	transcriptional regulator
L2Z16_16175	COG1960	acyl-CoA dehydrogenase activity
L2Z16_16220	COG1183	phosphatidylcholine synthase activity
L2Z16_16225	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z16_16255	COG0741	lytic transglycosylase activity
L2Z16_16255	COG1196	nuclear chromosome segregation
L2Z16_16255	COG0739	heme binding
L2Z16_16265	COG1702	phosphate starvation-inducible protein PhoH
L2Z16_16300	COG1295	ribonuclease BN
L2Z16_16305	COG0697	spore germination
L2Z16_16310	COG2169	Transcriptional regulator
L2Z16_16315	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z16_16360	COG0557	exoribonuclease II activity
L2Z16_16365	COG0339	signal peptide processing
L2Z16_16370	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z16_16400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z16_16405	COG1960	acyl-CoA dehydrogenase activity
L2Z16_16560	COG0626	cystathionine gamma-synthase activity
L2Z16_16565	COG0433	COG0433 Predicted ATPase
L2Z16_16570	COG1017	nitric oxide dioxygenase activity
L2Z16_16570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z16_16575	COG1959	2 iron, 2 sulfur cluster binding
L2Z16_16590	COG1301	dicarboxylic acid transport
L2Z16_16595	COG1946	Acyl-CoA thioesterase
L2Z16_16615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z16_16620	COG1040	competence protein
L2Z16_16625	COG0494	nUDIX hydrolase
L2Z16_16635	COG0598	Magnesium transport protein CorA
L2Z16_16645	COG2854	intermembrane phospholipid transfer
L2Z16_16655	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z16_16660	COG1127	ABC transporter
L2Z16_16670	COG0513	Belongs to the DEAD box helicase family
L2Z16_16690	COG0408	coproporphyrinogen oxidase activity
L2Z16_16705	COG1960	acyl-CoA dehydrogenase activity
L2Z16_16715	COG1983	PspC domain protein
L2Z16_16720	COG0517	IMP dehydrogenase activity
L2Z16_16765	COG0583	DNA-binding transcription factor activity
L2Z16_16805	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_16815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z16_16820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z16_16825	COG0833	amino acid
L2Z16_16855	COG1192	Involved in chromosome partitioning
L2Z16_16860	COG0628	permease
L2Z16_16875	COG1289	transmembrane transporter activity
L2Z16_16890	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z16_16895	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z16_16905	COG0277	FAD linked oxidase domain protein
L2Z16_16910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z16_16935	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z16_16940	COG5380	lipid catabolic process
L2Z16_16960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z16_17010	COG0194	GDP metabolic process
L2Z16_17025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z16_17045	COG3307	-O-antigen
L2Z16_17065	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z16_17070	COG1704	LemA family
L2Z16_17080	COG0493	'glutamate synthase
L2Z16_17085	COG0070	glutamate synthase
L2Z16_17085	COG0069	glutamate synthase activity
L2Z16_17085	COG0067	glutamate synthase
L2Z16_17135	COG2226	methyltransferase
L2Z16_17150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z16_17155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z16_17200	COG0833	amino acid
L2Z16_17285	COG0488	(ABC) transporter
L2Z16_17290	COG2873	o-acetylhomoserine
L2Z16_17295	COG4221	oxidoreductase activity
L2Z16_17300	COG0659	secondary active sulfate transmembrane transporter activity
L2Z16_17325	COG0427	acetyl-CoA hydrolase
L2Z16_17355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z16_17385	COG2329	Antibiotic biosynthesis monooxygenase
L2Z16_17400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z16_17465	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z16_17470	COG1733	regulation of RNA biosynthetic process
L2Z16_17505	COG0667	Aldo Keto reductase
L2Z16_17525	COG0583	DNA-binding transcription factor activity
L2Z16_17530	COG2814	Major facilitator Superfamily
L2Z16_17560	COG1335	isochorismatase
L2Z16_17570	COG1012	belongs to the aldehyde dehydrogenase family
L2Z16_17575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z16_17585	COG1113	amino acid transport
L2Z16_17595	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z16_17610	COG2814	Major facilitator Superfamily
L2Z16_17620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z16_17620	COG0352	thiamine-phosphate diphosphorylase activity
L2Z16_17620	COG0351	phosphomethylpyrimidine kinase
L2Z16_17640	COG1309	transcriptional regulator
L2Z16_17645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z16_17670	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z16_17680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z16_17685	COG3162	membrane
L2Z16_17690	COG2205	protein histidine kinase activity
L2Z16_17690	COG2198	Histidine kinase
L2Z16_17690	COG0784	Response regulator, receiver
L2Z16_17715	COG3328	transposase activity
L2Z16_17720	COG1522	sequence-specific DNA binding
L2Z16_17725	COG1335	isochorismatase
L2Z16_17730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z16_17740	COG0668	transmembrane transport
L2Z16_17745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z16_17750	COG1519	Transferase
L2Z16_17755	COG1902	pentaerythritol trinitrate reductase activity
L2Z16_17775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z16_17800	COG0426	domain, Protein
L2Z16_17800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z16_17805	COG4774	siderophore transport
L2Z16_17810	COG2119	membrane
L2Z16_17820	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z16_17830	COG4942	peptidase
L2Z16_17845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z16_17855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z16_17875	COG0189	ligase activity
L2Z16_17895	COG0708	Exodeoxyribonuclease III
L2Z16_17900	COG1393	Belongs to the ArsC family
L2Z16_17915	COG3706	GGDEF domain
L2Z16_17950	COG2351	hydroxyisourate hydrolase activity
L2Z16_17955	COG2233	PERMEase
L2Z16_17965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z16_17975	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z16_17980	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z16_17990	COG3150	esterase
L2Z16_18005	COG0791	NLP P60 protein
L2Z16_18005	COG1388	LysM domain
L2Z16_18020	COG2918	glutathione biosynthetic process
L2Z16_18035	COG2733	membrane
L2Z16_18040	COG0436	Aminotransferase
L2Z16_18045	COG0534	Mate efflux family protein
L2Z16_18145	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z16_18150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z16_18160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z16_18165	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z16_18180	COG0010	Belongs to the arginase family
L2Z16_18210	COG2188	Transcriptional regulator
L2Z16_18220	COG0523	cobalamin synthesis protein
L2Z16_18230	COG1113	amino acid transport
L2Z16_18240	COG0625	glutathione transferase activity
L2Z16_18260	COG1683	Conserved Protein
L2Z16_18265	COG0534	Mate efflux family protein
L2Z16_18270	COG0385	Bile acid
L2Z16_18275	COG1335	isochorismatase
L2Z16_18280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z16_18300	COG2116	formate transmembrane transporter activity
L2Z16_18305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z16_18310	COG2133	pyrroloquinoline quinone binding
L2Z16_18315	COG2983	Belongs to the UPF0260 family
L2Z16_18335	COG1194	a g-specific adenine glycosylase
L2Z16_18350	COG2818	Glycosylase
L2Z16_18355	COG1064	alcohol dehydrogenase
L2Z16_18360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z16_18375	COG0583	DNA-binding transcription factor activity
L2Z16_18380	COG0656	L-ascorbic acid biosynthetic process
L2Z16_18385	COG2814	Major facilitator Superfamily
L2Z16_18420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z16_18435	COG2233	PERMEase
L2Z16_18475	COG0733	neurotransmitter:sodium symporter activity
L2Z16_18515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z16_18520	COG0657	acetylesterase activity
L2Z16_18540	COG0583	DNA-binding transcription factor activity
L2Z16_18570	COG2951	lytic endotransglycosylase activity
L2Z16_18575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z16_18590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z16_18600	COG0671	phosphoesterase, PA-phosphatase related
L2Z16_18605	COG0861	Integral membrane protein TerC family
L2Z16_18615	COG0754	glutathionylspermidine amidase activity
L2Z16_18625	COG0402	S-adenosylhomocysteine deaminase activity
L2Z16_18640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z16_18645	COG1230	cation diffusion facilitator family transporter
L2Z16_18660	COG0706	membrane insertase activity
L2Z16_18685	COG0592	DNA-directed DNA polymerase activity
L2Z16_18695	COG0187	DNA topoisomerase II activity
L2Z16_18705	COG0586	Pfam SNARE associated Golgi protein
L2Z16_18710	COG0488	(ABC) transporter
L2Z16_18735	COG0596	Alpha beta hydrolase
L2Z16_18740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z16_18745	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)