locus-tag	class	description
L2Z18_00035	COG2985	domain, Protein
L2Z18_00045	COG2995	paraquat-inducible protein a
L2Z18_00050	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z18_00050	COG3008	intermembrane lipid transfer
L2Z18_00080	COG0488	(ABC) transporter
L2Z18_00085	COG3173	Aminoglycoside phosphotransferase
L2Z18_00095	COG2433	Pfam Transposase IS66
L2Z18_00155	COG2985	domain, Protein
L2Z18_00165	COG2995	paraquat-inducible protein a
L2Z18_00170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z18_00170	COG3008	intermembrane lipid transfer
L2Z18_00200	COG0488	(ABC) transporter
L2Z18_00205	COG3173	Aminoglycoside phosphotransferase
L2Z18_00215	COG2433	Pfam Transposase IS66
L2Z18_00255	COG1301	dicarboxylic acid transport
L2Z18_00265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z18_00270	COG2011	ABC-type metal ion transport system permease component
L2Z18_00275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z18_00280	COG1464	Belongs to the NlpA lipoprotein family
L2Z18_00285	COG0151	Belongs to the GarS family
L2Z18_00290	COG0138	bifunctional purine biosynthesis protein purh
L2Z18_00295	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z18_00325	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z18_00335	COG1305	Transglutaminase-like
L2Z18_00345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z18_00350	COG0305	Participates in initiation and elongation during chromosome replication
L2Z18_00375	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z18_00385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z18_00390	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z18_00415	COG0726	polysaccharide deacetylase
L2Z18_00415	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z18_00420	COG1215	transferase activity, transferring glycosyl groups
L2Z18_00425	COG3658	cytochrome
L2Z18_00435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z18_00450	COG0583	DNA-binding transcription factor activity
L2Z18_00470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z18_00475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z18_00490	COG1960	acyl-CoA dehydrogenase activity
L2Z18_00495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z18_00500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z18_00525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z18_00530	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z18_00540	COG2205	protein histidine kinase activity
L2Z18_00545	COG0745	RESPONSE REGULATOR receiver
L2Z18_00550	COG0174	glutamine synthetase
L2Z18_00570	COG0729	surface antigen
L2Z18_00595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z18_00600	COG2814	Major facilitator Superfamily
L2Z18_00615	COG0583	DNA-binding transcription factor activity
L2Z18_00630	COG1187	pseudouridine synthase activity
L2Z18_00650	COG0802	atpase or kinase
L2Z18_00655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z18_00665	COG1923	regulation of RNA biosynthetic process
L2Z18_00670	COG0697	spore germination
L2Z18_00685	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z18_00695	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z18_00700	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z18_00700	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z18_00705	COG4302	ethanolamine ammonia-lyase activity
L2Z18_00710	COG4303	Ethanolamine ammonia lyase large subunit
L2Z18_00715	COG0531	amino acid
L2Z18_00735	COG1454	alcohol dehydrogenase
L2Z18_00740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z18_00750	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z18_00770	COG0308	aminopeptidase N
L2Z18_00800	COG1605	Chorismate mutase
L2Z18_00820	COG1309	transcriptional regulator
L2Z18_00830	COG0668	transmembrane transport
L2Z18_00865	COG4773	Receptor
L2Z18_00885	COG0488	(ABC) transporter
L2Z18_00890	COG0589	response to stress
L2Z18_00915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z18_00925	COG3135	benzoate transporter
L2Z18_00930	COG1522	sequence-specific DNA binding
L2Z18_00940	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z18_00945	COG0583	DNA-binding transcription factor activity
L2Z18_00955	COG0183	Belongs to the thiolase family
L2Z18_00965	COG2030	dehydratase
L2Z18_00970	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z18_00985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z18_00995	COG0824	Thioesterase
L2Z18_01000	COG1454	alcohol dehydrogenase
L2Z18_01010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z18_01030	COG0069	glutamate synthase activity
L2Z18_01240	COG5410	chromosome segregation
L2Z18_01360	COG0739	heme binding
L2Z18_01425	COG2814	Major facilitator Superfamily
L2Z18_01440	COG0511	ligase activity, forming carbon-carbon bonds
L2Z18_01460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z18_01460	COG1116	anion transmembrane transporter activity
L2Z18_01465	COG0745	RESPONSE REGULATOR receiver
L2Z18_01475	COG2146	nitrite reductase [NAD(P)H] activity
L2Z18_01475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z18_01480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z18_01485	COG0243	molybdopterin cofactor binding
L2Z18_01495	COG0243	molybdopterin cofactor binding
L2Z18_01500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z18_01515	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z18_01515	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z18_01520	COG0303	'Molybdopterin
L2Z18_01530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z18_01535	COG0697	spore germination
L2Z18_01555	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z18_01560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z18_01625	COG2204	response regulator
L2Z18_01630	COG3852	Histidine kinase
L2Z18_01650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z18_01655	COG0575	Belongs to the CDS family
L2Z18_01690	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z18_01705	COG2137	regulation of response to DNA damage stimulus
L2Z18_01715	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z18_01720	COG1011	Hydrolase
L2Z18_01745	COG1522	sequence-specific DNA binding
L2Z18_01755	COG1113	amino acid transport
L2Z18_01775	COG0659	secondary active sulfate transmembrane transporter activity
L2Z18_01780	COG2135	peptidase activity
L2Z18_01795	COG3300	MHYT domain
L2Z18_01795	COG5001	Diguanylate cyclase
L2Z18_01815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z18_01815	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z18_01815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z18_01820	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z18_01825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z18_01825	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z18_01855	COG0024	Methionine aminopeptidase
L2Z18_01860	COG0583	DNA-binding transcription factor activity
L2Z18_01870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z18_01875	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z18_01880	COG0516	GMP reductase activity
L2Z18_01880	COG0517	IMP dehydrogenase activity
L2Z18_01905	COG0552	protein localization to endoplasmic reticulum
L2Z18_01915	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z18_01930	COG4890	Cyd operon protein YbgT
L2Z18_01935	COG1294	oxidase, subunit
L2Z18_01950	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z18_01960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z18_01965	COG4774	siderophore transport
L2Z18_01980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z18_01985	COG0569	domain protein
L2Z18_01990	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z18_02020	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z18_02025	COG0542	response to heat
L2Z18_02050	COG1902	pentaerythritol trinitrate reductase activity
L2Z18_02050	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z18_02095	COG2323	membrane
L2Z18_02100	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z18_02110	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z18_02115	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z18_02120	COG0183	Belongs to the thiolase family
L2Z18_02125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z18_02130	COG0596	Alpha beta hydrolase
L2Z18_02135	COG2271	Major facilitator Superfamily
L2Z18_02140	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z18_02145	COG3485	protocatechuate 3,4-dioxygenase
L2Z18_02150	COG3485	protocatechuate 3,4-dioxygenase
L2Z18_02155	COG0710	3-dehydroquinate dehydratase activity
L2Z18_02160	COG3420	alginic acid biosynthetic process
L2Z18_02165	COG3659	wide pore channel activity
L2Z18_02170	COG4993	Dehydrogenase
L2Z18_02180	COG2391	methyltransferase activity
L2Z18_02195	COG1414	Transcriptional regulator
L2Z18_02200	COG0583	DNA-binding transcription factor activity
L2Z18_02205	COG1960	acyl-CoA dehydrogenase activity
L2Z18_02230	COG2814	Major facilitator Superfamily
L2Z18_02240	COG0154	amidase activity
L2Z18_02260	COG4638	Rieske (2fe-2S)
L2Z18_02270	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_02280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z18_02290	COG3733	amine oxidase
L2Z18_02300	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_02310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z18_02315	COG0183	Belongs to the thiolase family
L2Z18_02320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z18_02325	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z18_02335	COG4829	muconolactone delta-isomerase
L2Z18_02340	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z18_02345	COG0583	DNA-binding transcription factor activity
L2Z18_02355	COG2186	Transcriptional regulator
L2Z18_02375	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_02395	COG1960	acyl-CoA dehydrogenase activity
L2Z18_02400	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_02405	COG3829	transcription factor binding
L2Z18_02415	COG3162	membrane
L2Z18_02430	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_02445	COG0753	catalase activity
L2Z18_02465	COG1846	Transcriptional regulator
L2Z18_02470	COG1902	pentaerythritol trinitrate reductase activity
L2Z18_02470	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z18_02480	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z18_02510	COG1309	transcriptional regulator
L2Z18_02520	COG1335	isochorismatase
L2Z18_02525	COG0583	DNA-binding transcription factor activity
L2Z18_02535	COG0475	glutathione-regulated potassium exporter activity
L2Z18_02535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z18_02545	COG1473	amidohydrolase
L2Z18_02555	COG2831	hemolysin activation secretion protein
L2Z18_02560	COG3210	domain, Protein
L2Z18_02590	COG2188	Transcriptional regulator
L2Z18_02605	COG0583	DNA-binding transcription factor activity
L2Z18_02635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z18_02665	COG1566	PFAM secretion protein HlyD family protein
L2Z18_02680	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_02685	COG0129	dihydroxy-acid dehydratase activity
L2Z18_02695	COG0583	DNA-binding transcription factor activity
L2Z18_02700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z18_02710	COG2084	Dehydrogenase
L2Z18_02715	COG2207	Transcriptional regulator
L2Z18_02730	COG1064	alcohol dehydrogenase
L2Z18_02740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z18_02745	COG1120	ATPase activity
L2Z18_02765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z18_02885	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z18_02935	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_02950	COG2207	Transcriptional regulator
L2Z18_02960	COG2205	protein histidine kinase activity
L2Z18_02965	COG0745	RESPONSE REGULATOR receiver
L2Z18_02970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z18_02975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z18_02980	COG1538	Outer membrane efflux protein
L2Z18_02990	COG2072	flavoprotein involved in K transport
L2Z18_03010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z18_03030	COG3539	Fimbrial protein
L2Z18_03060	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z18_03070	COG0753	catalase activity
L2Z18_03085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z18_03145	COG1535	isochorismatase
L2Z18_03145	COG3433	isochorismatase activity
L2Z18_03150	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_03155	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z18_03160	COG4149	molybdate abc transporter
L2Z18_03165	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z18_03175	COG4638	Rieske (2fe-2S)
L2Z18_03180	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z18_03185	COG0543	2 iron, 2 sulfur cluster binding
L2Z18_03185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z18_03210	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_03225	COG2207	Transcriptional regulator
L2Z18_03235	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_03240	COG2610	gluconate transmembrane transporter activity
L2Z18_03250	COG0583	DNA-binding transcription factor activity
L2Z18_03260	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z18_03265	COG2031	fatty acid transporter
L2Z18_03270	COG0183	Belongs to the thiolase family
L2Z18_03275	COG0583	DNA-binding transcription factor activity
L2Z18_03280	COG0583	DNA-binding transcription factor activity
L2Z18_03295	COG1027	Aspartate ammonia-lyase
L2Z18_03305	COG0477	Major facilitator Superfamily
L2Z18_03325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z18_03330	COG4521	taurine ABC transporter
L2Z18_03345	COG2188	Transcriptional regulator
L2Z18_03355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z18_03360	COG1733	regulation of RNA biosynthetic process
L2Z18_03365	COG3708	Transcriptional regulator
L2Z18_03365	COG2207	Transcriptional regulator
L2Z18_03380	COG0730	response to heat
L2Z18_03395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z18_03395	COG3453	Protein conserved in bacteria
L2Z18_03405	COG3781	membrane
L2Z18_03410	COG1063	alcohol dehydrogenase
L2Z18_03420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z18_03425	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z18_03430	COG0022	dehydrogenase e1 component
L2Z18_03435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z18_03440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z18_03455	COG3706	GGDEF domain
L2Z18_03470	COG0133	tryptophan synthase activity
L2Z18_03480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z18_03515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z18_03540	COG2226	methyltransferase
L2Z18_03595	COG0842	Transport permease protein
L2Z18_03600	COG0842	Transport permease protein
L2Z18_03605	COG1131	(ABC) transporter
L2Z18_03620	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z18_03625	COG4773	Receptor
L2Z18_03645	COG0730	response to heat
L2Z18_03650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z18_03670	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z18_03685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z18_03725	COG4264	IucA IucC family
L2Z18_03730	COG4264	IucA IucC family
L2Z18_03750	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z18_03765	COG1960	acyl-CoA dehydrogenase activity
L2Z18_03770	COG1960	acyl-CoA dehydrogenase activity
L2Z18_03775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z18_03780	COG2207	Transcriptional regulator
L2Z18_03785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z18_03790	COG0776	regulation of translation
L2Z18_03815	COG0822	iron-sulfur transferase activity
L2Z18_03820	COG0316	Belongs to the HesB IscA family
L2Z18_03850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z18_03870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z18_03875	COG0702	epimerase
L2Z18_03910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z18_03920	COG0339	signal peptide processing
L2Z18_03970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z18_03975	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z18_04005	COG0776	regulation of translation
L2Z18_04070	COG0084	hydrolase, TatD family'
L2Z18_04090	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z18_04095	COG1132	(ABC) transporter
L2Z18_04105	COG0811	peptide transport
L2Z18_04110	COG1475	DNA binding
L2Z18_04115	COG1192	Involved in chromosome partitioning
L2Z18_04125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z18_04140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z18_04145	COG0191	fructose-bisphosphate aldolase activity
L2Z18_04165	COG0424	maF-like protein
L2Z18_04170	COG2850	peptidyl-arginine hydroxylation
L2Z18_04180	COG0640	Transcriptional regulator
L2Z18_04195	COG3619	membrane
L2Z18_04200	COG3122	Protein conserved in bacteria
L2Z18_04205	COG1132	(ABC) transporter
L2Z18_04225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z18_04230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z18_04240	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z18_04240	COG0506	proline dehydrogenase activity
L2Z18_04240	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z18_04245	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z18_04260	COG3698	Phosphodiester glycosidase
L2Z18_04270	COG2353	YceI-like domain
L2Z18_04280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z18_04325	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z18_04325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z18_04350	COG3539	Fimbrial protein
L2Z18_04355	COG3121	Chaperone
L2Z18_04380	COG0697	spore germination
L2Z18_04390	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z18_04400	COG0583	DNA-binding transcription factor activity
L2Z18_04420	COG1309	transcriptional regulator
L2Z18_04435	COG1522	sequence-specific DNA binding
L2Z18_04445	COG1126	abc transporter atp-binding protein
L2Z18_04450	COG0765	amino acid transport
L2Z18_04455	COG0765	amino acid transport
L2Z18_04485	COG1464	Belongs to the NlpA lipoprotein family
L2Z18_04495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z18_04500	COG2011	ABC-type metal ion transport system permease component
L2Z18_04505	COG0012	GTP binding
L2Z18_04530	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z18_04570	COG0386	Belongs to the glutathione peroxidase family
L2Z18_04580	COG0436	Aminotransferase
L2Z18_04620	COG3634	alkyl hydroperoxide reductase activity
L2Z18_04635	COG0583	DNA-binding transcription factor activity
L2Z18_04640	COG0798	PFAM Bile acid sodium symporter
L2Z18_04645	COG0640	Transcriptional regulator
L2Z18_04660	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z18_04680	COG1953	Uracil, thiamine, allantoin
L2Z18_04690	COG2175	clavaminate synthase activity
L2Z18_04695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z18_04700	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z18_04705	COG4521	taurine ABC transporter
L2Z18_04715	COG0477	Major facilitator Superfamily
L2Z18_04735	COG1271	oxidase subunit
L2Z18_04740	COG1294	oxidase, subunit
L2Z18_04750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z18_04770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z18_04790	COG3052	prosthetic group binding
L2Z18_04795	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z18_04805	COG2814	Major facilitator Superfamily
L2Z18_04825	COG1346	cytolysis
L2Z18_04835	COG0583	DNA-binding transcription factor activity
L2Z18_04840	COG0625	glutathione transferase activity
L2Z18_04845	COG0625	glutathione transferase activity
L2Z18_04850	COG0583	DNA-binding transcription factor activity
L2Z18_04865	COG1045	serine acetyltransferase
L2Z18_04870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z18_04875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z18_04885	COG1280	lysine exporter protein (LysE YggA)
L2Z18_04900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z18_04905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z18_04910	COG1126	abc transporter atp-binding protein
L2Z18_04915	COG0765	amino acid transport
L2Z18_04920	COG0765	amino acid transport
L2Z18_04940	COG0784	Response regulator, receiver
L2Z18_04940	COG2205	protein histidine kinase activity
L2Z18_04960	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z18_04980	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_05030	COG0583	DNA-binding transcription factor activity
L2Z18_05050	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z18_05055	COG1309	transcriptional regulator
L2Z18_05060	COG1960	acyl-CoA dehydrogenase activity
L2Z18_05065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z18_05070	COG1024	Enoyl-CoA hydratase
L2Z18_05075	COG4770	biotin carboxylase activity
L2Z18_05085	COG0583	DNA-binding transcription factor activity
L2Z18_05100	COG1960	acyl-CoA dehydrogenase activity
L2Z18_05110	COG2814	Major facilitator Superfamily
L2Z18_05120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z18_05125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z18_05130	COG2814	Major facilitator Superfamily
L2Z18_05135	COG1960	acyl-CoA dehydrogenase activity
L2Z18_05140	COG1024	Enoyl-CoA hydratase
L2Z18_05145	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_05150	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z18_05155	COG0183	Belongs to the thiolase family
L2Z18_05165	COG2814	Major facilitator Superfamily
L2Z18_05175	COG1024	Enoyl-CoA hydratase
L2Z18_05190	COG1960	acyl-CoA dehydrogenase activity
L2Z18_05195	COG2814	Major facilitator Superfamily
L2Z18_05200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z18_05205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z18_05220	COG3842	ATPase activity
L2Z18_05225	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z18_05235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z18_05240	COG1414	Transcriptional regulator
L2Z18_05250	COG0583	DNA-binding transcription factor activity
L2Z18_05255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z18_05260	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_05270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z18_05280	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_05285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z18_05290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z18_05295	COG2267	carboxylic ester hydrolase activity
L2Z18_05315	COG3038	cytochrome b561
L2Z18_05320	COG0753	catalase activity
L2Z18_05350	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z18_05360	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z18_05365	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z18_05370	COG0183	Belongs to the thiolase family
L2Z18_05375	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z18_05380	COG1024	Enoyl-CoA hydratase
L2Z18_05385	COG1024	Enoyl-CoA hydratase
L2Z18_05390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z18_05395	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z18_05400	COG3396	Phenylacetate-CoA oxygenase
L2Z18_05405	COG3460	Phenylacetate-CoA oxygenase
L2Z18_05410	COG3396	Phenylacetate-CoA oxygenase
L2Z18_05415	COG2030	dehydratase
L2Z18_05415	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_05420	COG1760	l-serine dehydratase
L2Z18_05425	COG0531	amino acid
L2Z18_05430	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_05445	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z18_05455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z18_05475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z18_05485	COG0789	Transcriptional regulator
L2Z18_05500	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z18_05515	COG2807	transmembrane transport
L2Z18_05520	COG0590	tRNA wobble adenosine to inosine editing
L2Z18_05640	COG1116	anion transmembrane transporter activity
L2Z18_05645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z18_05655	COG0864	Transcriptional regulator
L2Z18_05675	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z18_05680	COG0439	Biotin carboxylase
L2Z18_05695	COG1063	alcohol dehydrogenase
L2Z18_05705	COG1309	transcriptional regulator
L2Z18_05725	COG0038	chloride channel
L2Z18_05730	COG4770	biotin carboxylase activity
L2Z18_05750	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z18_05755	COG0583	DNA-binding transcription factor activity
L2Z18_05805	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z18_05825	COG2814	Major facilitator Superfamily
L2Z18_05840	COG1560	Kdo2-lipid A biosynthetic process
L2Z18_05850	COG5006	permease, DMT superfamily
L2Z18_05855	COG1522	sequence-specific DNA binding
L2Z18_05870	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z18_05880	COG4122	O-methyltransferase activity
L2Z18_05910	COG1538	Outer membrane efflux protein
L2Z18_05915	COG1137	ATPase activity
L2Z18_05920	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z18_05930	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z18_05935	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z18_05935	COG0517	IMP dehydrogenase activity
L2Z18_05970	COG2814	Major facilitator Superfamily
L2Z18_06005	COG1278	Cold shock
L2Z18_06010	COG1280	lysine exporter protein (LysE YggA)
L2Z18_06040	COG1570	exodeoxyribonuclease VII activity
L2Z18_06090	COG0583	DNA-binding transcription factor activity
L2Z18_06100	COG4638	Rieske (2fe-2S)
L2Z18_06105	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z18_06110	COG0633	Ferredoxin
L2Z18_06110	COG0543	2 iron, 2 sulfur cluster binding
L2Z18_06115	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_06120	COG3135	benzoate transporter
L2Z18_06125	COG2814	Major facilitator Superfamily
L2Z18_06140	COG1643	Atp-dependent helicase
L2Z18_06145	COG0450	alkyl hydroperoxide reductase
L2Z18_06155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z18_06165	COG3634	alkyl hydroperoxide reductase activity
L2Z18_06185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z18_06190	COG0625	glutathione transferase activity
L2Z18_06200	COG2885	chlorophyll binding
L2Z18_06235	COG0542	response to heat
L2Z18_06250	COG1765	OsmC-like protein
L2Z18_06270	COG0667	Aldo Keto reductase
L2Z18_06285	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z18_06295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z18_06305	COG0527	aspartate kinase activity
L2Z18_06315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z18_06325	COG3038	cytochrome b561
L2Z18_06330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z18_06335	COG2252	PERMEase
L2Z18_06345	COG2072	flavoprotein involved in K transport
L2Z18_06360	COG1741	Belongs to the pirin family
L2Z18_06365	COG1309	transcriptional regulator
L2Z18_06390	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2Z18_06430	COG1902	pentaerythritol trinitrate reductase activity
L2Z18_06430	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z18_06440	COG5001	Diguanylate cyclase
L2Z18_06440	COG4251	negative regulation of phosphorylation
L2Z18_06440	COG3706	GGDEF domain
L2Z18_06440	COG2203	Gaf domain
L2Z18_06450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z18_06470	COG4172	Belongs to the ABC transporter superfamily
L2Z18_06475	COG4239	(ABC) transporter, permease
L2Z18_06480	COG4174	ABC transporter (Permease)
L2Z18_06490	COG0741	lytic transglycosylase activity
L2Z18_06490	COG1388	LysM domain
L2Z18_06490	COG0741	lytic transglycosylase activity
L2Z18_06490	COG1388	LysM domain
L2Z18_06495	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z18_06535	COG0583	DNA-binding transcription factor activity
L2Z18_06540	COG1279	arginine transmembrane transporter activity
L2Z18_06560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z18_06565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z18_06570	COG0006	proline dipeptidase activity
L2Z18_06610	COG2194	sulfuric ester hydrolase activity
L2Z18_06655	COG0739	heme binding
L2Z18_06985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z18_07010	COG3384	dioxygenase
L2Z18_07020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z18_07025	COG2878	Part of a membrane complex involved in electron transport
L2Z18_07030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z18_07055	COG0768	penicillin binding
L2Z18_07060	COG0742	ribosomal rna small subunit methyltransferase
L2Z18_07075	COG0830	nickel cation binding
L2Z18_07085	COG0804	urea catabolic process
L2Z18_07125	COG1253	flavin adenine dinucleotide binding
L2Z18_07130	COG2851	Citrate transporter
L2Z18_07185	COG1773	rubredoxin
L2Z18_07190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z18_07200	COG0583	DNA-binding transcription factor activity
L2Z18_07225	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z18_07230	COG4181	ATPase activity
L2Z18_07275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z18_07295	COG0306	phosphate transporter
L2Z18_07305	COG3958	Transketolase
L2Z18_07310	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z18_07315	COG2271	Major facilitator Superfamily
L2Z18_07320	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_07325	COG0583	DNA-binding transcription factor activity
L2Z18_07340	COG2223	nitrite transmembrane transporter activity
L2Z18_07345	COG2207	Transcriptional regulator
L2Z18_07350	COG2066	Belongs to the glutaminase family
L2Z18_07355	COG0242	peptide deformylase activity
L2Z18_07360	COG0477	Major facilitator Superfamily
L2Z18_07370	COG0028	Belongs to the TPP enzyme family
L2Z18_07385	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_07390	COG2267	carboxylic ester hydrolase activity
L2Z18_07400	COG2271	Major facilitator Superfamily
L2Z18_07405	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z18_07415	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_07435	COG1414	Transcriptional regulator
L2Z18_07450	COG1024	Enoyl-CoA hydratase
L2Z18_07460	COG1215	transferase activity, transferring glycosyl groups
L2Z18_07465	COG0726	polysaccharide deacetylase
L2Z18_07465	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z18_07475	COG4681	YaeQ
L2Z18_07485	COG0523	cobalamin synthesis protein
L2Z18_07495	COG1607	acyl-coa hydrolase
L2Z18_07505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z18_07510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z18_07515	COG1309	transcriptional regulator
L2Z18_07540	COG2040	homocysteine
L2Z18_07545	COG0531	amino acid
L2Z18_07600	COG1595	DNA-templated transcription, initiation
L2Z18_07610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z18_07615	COG0477	Major facilitator Superfamily
L2Z18_07635	COG0084	hydrolase, TatD family'
L2Z18_07670	COG0629	single-stranded DNA binding
L2Z18_07725	COG0582	viral genome integration into host DNA
L2Z18_07830	COG0592	DNA-directed DNA polymerase activity
L2Z18_07870	COG2026	Addiction module toxin, RelE StbE family
L2Z18_08065	COG1484	DNA-dependent DNA replication
L2Z18_08155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z18_08225	COG0405	Gamma-glutamyltransferase
L2Z18_08230	COG2814	Major facilitator Superfamily
L2Z18_08240	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z18_08255	COG1090	epimerase
L2Z18_08275	COG0420	3'-5' exonuclease activity
L2Z18_08300	COG0735	belongs to the Fur family
L2Z18_08305	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z18_08325	COG0121	glutamine amidotransferase
L2Z18_08340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z18_08350	COG0210	DNA helicase
L2Z18_08355	COG2885	chlorophyll binding
L2Z18_08360	COG0204	Acyl-transferase
L2Z18_08375	COG2894	cell division
L2Z18_08400	COG1280	lysine exporter protein (LysE YggA)
L2Z18_08405	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z18_08405	COG1674	ftsk spoiiie
L2Z18_08410	COG0492	ferredoxin-NADP+ reductase activity
L2Z18_08415	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z18_08425	COG0456	acetyltransferase
L2Z18_08470	COG1981	membrane
L2Z18_08485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z18_08485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z18_08505	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_08515	COG0657	acetylesterase activity
L2Z18_08525	COG0473	3-isopropylmalate dehydrogenase activity
L2Z18_08530	COG0583	DNA-binding transcription factor activity
L2Z18_08550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z18_08575	COG0564	pseudouridine synthase activity
L2Z18_08585	COG0358	DNA primase activity
L2Z18_08600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z18_08630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z18_08660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z18_08670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z18_08670	COG0351	phosphomethylpyrimidine kinase
L2Z18_08670	COG0352	thiamine-phosphate diphosphorylase activity
L2Z18_08675	COG1652	LysM domain
L2Z18_08700	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z18_08705	COG3101	peptidyl-lysine hydroxylation
L2Z18_08710	COG0009	L-threonylcarbamoyladenylate synthase
L2Z18_08715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z18_08720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z18_08735	COG4106	trans-aconitate 2-methyltransferase activity
L2Z18_08750	COG2226	methyltransferase
L2Z18_08750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z18_08750	COG0596	Alpha beta hydrolase
L2Z18_08755	COG1877	trehalose-phosphatase activity
L2Z18_08760	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z18_08765	COG2223	nitrite transmembrane transporter activity
L2Z18_08785	COG1196	nuclear chromosome segregation
L2Z18_08795	COG0730	response to heat
L2Z18_08810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z18_08820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z18_08870	COG0489	protein tyrosine kinase activity
L2Z18_08880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z18_08880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z18_08910	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z18_08915	COG2081	HI0933 family
L2Z18_08925	COG0668	transmembrane transport
L2Z18_08945	COG0583	DNA-binding transcription factor activity
L2Z18_08965	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z18_08970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z18_09000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z18_09040	COG0745	RESPONSE REGULATOR receiver
L2Z18_09060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z18_09070	COG2205	protein histidine kinase activity
L2Z18_09140	COG4993	Dehydrogenase
L2Z18_09165	COG0384	phenazine biosynthesis protein PhzF
L2Z18_09195	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z18_09210	COG0583	DNA-binding transcription factor activity
L2Z18_09240	COG0583	DNA-binding transcription factor activity
L2Z18_09255	COG0583	DNA-binding transcription factor activity
L2Z18_09260	COG1053	succinate dehydrogenase
L2Z18_09270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z18_09275	COG2814	Major facilitator Superfamily
L2Z18_09280	COG1960	acyl-CoA dehydrogenase activity
L2Z18_09285	COG0583	DNA-binding transcription factor activity
L2Z18_09290	COG1063	alcohol dehydrogenase
L2Z18_09320	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z18_09325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z18_09330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z18_09345	COG3667	copper resistance
L2Z18_09350	COG2132	Multicopper oxidase
L2Z18_09360	COG0561	phosphatase activity
L2Z18_09365	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z18_09390	COG1214	PFAM Peptidase M22, glycoprotease
L2Z18_09455	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z18_09460	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z18_09465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z18_09525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z18_09535	COG1846	Transcriptional regulator
L2Z18_09540	COG1764	response to oxidative stress
L2Z18_09590	COG0037	tRNA processing
L2Z18_09600	COG0248	Ppx GppA phosphatase
L2Z18_09630	COG0072	phenylalanine-tRNA ligase activity
L2Z18_09675	COG1238	metal cluster binding
L2Z18_09680	COG0625	glutathione transferase activity
L2Z18_09695	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z18_09700	COG3028	Belongs to the UPF0307 family
L2Z18_09705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z18_09725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z18_09730	COG0617	tRNA 3'-terminal CCA addition
L2Z18_09735	COG1555	photosystem II stabilization
L2Z18_09740	COG3956	TIGRFAM MazG family protein
L2Z18_09750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z18_09770	COG5002	protein histidine kinase activity
L2Z18_09770	COG2205	protein histidine kinase activity
L2Z18_09770	COG0784	Response regulator, receiver
L2Z18_09775	COG1024	Enoyl-CoA hydratase
L2Z18_09780	COG2084	Dehydrogenase
L2Z18_09785	COG3622	Belongs to the hyi family
L2Z18_09815	COG0697	spore germination
L2Z18_09825	COG2814	Major facilitator Superfamily
L2Z18_09830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z18_09840	COG0583	DNA-binding transcription factor activity
L2Z18_09850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z18_09865	COG0084	hydrolase, TatD family'
L2Z18_09880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z18_09910	COG0440	acetolactate synthase activity
L2Z18_09915	COG0028	Belongs to the TPP enzyme family
L2Z18_09940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z18_09945	COG1136	(ABC) transporter
L2Z18_09945	COG0577	efflux transmembrane transporter activity
L2Z18_09950	COG1538	Outer membrane efflux protein
L2Z18_09965	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z18_09970	COG1162	GTPase activity
L2Z18_09980	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z18_10000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z18_10005	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_10045	COG2986	histidine ammonia-lyase
L2Z18_10060	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z18_10070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z18_10115	COG1426	Protein conserved in bacteria
L2Z18_10150	COG0793	Belongs to the peptidase S41A family
L2Z18_10165	COG2267	carboxylic ester hydrolase activity
L2Z18_10175	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_10180	COG3265	gluconokinase activity
L2Z18_10190	COG0800	Aldolase
L2Z18_10205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z18_10210	COG0280	phosphate acetyltransferase
L2Z18_10210	COG0857	belongs to the CobB CobQ family
L2Z18_10215	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z18_10215	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z18_10235	COG0740	serine-type endopeptidase activity
L2Z18_10245	COG4774	siderophore transport
L2Z18_10255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z18_10265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z18_10265	COG2813	Specifically methylates the guanine in position
L2Z18_10365	COG0788	formyltetrahydrofolate deformylase activity
L2Z18_10390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z18_10390	COG4651	solute:proton antiporter activity
L2Z18_10410	COG0724	RNA recognition motif
L2Z18_10415	COG0210	DNA helicase
L2Z18_10440	COG1733	regulation of RNA biosynthetic process
L2Z18_10450	COG2900	Belongs to the SlyX family
L2Z18_10455	COG0488	(ABC) transporter
L2Z18_10460	COG1280	lysine exporter protein (LysE YggA)
L2Z18_10465	COG1560	Kdo2-lipid A biosynthetic process
L2Z18_10475	COG1301	dicarboxylic acid transport
L2Z18_10530	COG0473	3-isopropylmalate dehydrogenase activity
L2Z18_10595	COG0583	DNA-binding transcription factor activity
L2Z18_10605	COG0625	glutathione transferase activity
L2Z18_10610	COG2378	regulation of single-species biofilm formation
L2Z18_10615	COG0546	phosphoglycolate phosphatase activity
L2Z18_10625	COG1530	ribonuclease E activity
L2Z18_10630	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z18_10645	COG0583	DNA-binding transcription factor activity
L2Z18_10650	COG4221	oxidoreductase activity
L2Z18_10655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z18_10665	COG0534	Mate efflux family protein
L2Z18_10680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z18_10720	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z18_10725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z18_10740	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z18_10750	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z18_10750	COG0644	oxidoreductase
L2Z18_10755	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z18_10760	COG4535	Mg2 and Co2 transporter CorC
L2Z18_10770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z18_10790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z18_10795	COG0475	glutathione-regulated potassium exporter activity
L2Z18_10795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z18_10800	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z18_10810	COG0484	heat shock protein binding
L2Z18_10815	COG0789	Transcriptional regulator
L2Z18_10820	COG0598	Magnesium transport protein CorA
L2Z18_10835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z18_10840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z18_10845	COG1074	ATP-dependent DNA helicase activity
L2Z18_10850	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z18_10870	COG2226	methyltransferase
L2Z18_10885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z18_10890	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z18_10905	COG2111	Na H antiporter
L2Z18_10905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z18_10910	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z18_10915	COG0651	ATP synthesis coupled electron transport
L2Z18_10920	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z18_10925	COG2212	antiporter activity
L2Z18_10930	COG1320	monovalent cation:proton antiporter activity
L2Z18_10945	COG0195	Participates in both transcription termination and antitermination
L2Z18_10995	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z18_11000	COG0237	dephospho-CoA kinase activity
L2Z18_11010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z18_11025	COG0497	DNA recombination
L2Z18_11035	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z18_11065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z18_11065	COG2169	Transcriptional regulator
L2Z18_11070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z18_11135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z18_11150	COG0326	Molecular chaperone. Has ATPase activity
L2Z18_11165	COG2056	Na+-H+ antiporter family
L2Z18_11170	COG0596	Alpha beta hydrolase
L2Z18_11265	COG0546	phosphoglycolate phosphatase activity
L2Z18_11270	COG1716	ATPase activity
L2Z18_11315	COG0181	hydroxymethylbilane synthase activity
L2Z18_11325	COG3275	phosphorelay sensor kinase activity
L2Z18_11345	COG1538	Outer membrane efflux protein
L2Z18_11350	COG0697	spore germination
L2Z18_11375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z18_11380	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z18_11385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z18_11390	COG0772	Belongs to the SEDS family
L2Z18_11415	COG4974	Belongs to the 'phage' integrase family
L2Z18_11420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z18_11430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z18_11440	COG2197	response regulator
L2Z18_11455	COG0793	Belongs to the peptidase S41A family
L2Z18_11460	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z18_11465	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z18_11505	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z18_11505	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z18_11515	COG0004	ammonium transporteR
L2Z18_11520	COG0347	Belongs to the P(II) protein family
L2Z18_11595	COG1061	Type III restriction enzyme res subunit
L2Z18_11600	COG1002	Type II restriction enzyme, methylase subunits
L2Z18_11610	COG0659	secondary active sulfate transmembrane transporter activity
L2Z18_11615	COG0589	response to stress
L2Z18_11660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z18_11680	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z18_11695	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z18_11705	COG0477	Major facilitator Superfamily
L2Z18_11710	COG2860	membrane
L2Z18_11720	COG1253	flavin adenine dinucleotide binding
L2Z18_11740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z18_11780	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z18_11795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z18_11865	COG0758	DNA mediated transformation
L2Z18_11875	COG0697	spore germination
L2Z18_11880	COG1309	transcriptional regulator
L2Z18_11895	COG0386	Belongs to the glutathione peroxidase family
L2Z18_11960	COG1121	(ABC) transporter
L2Z18_11965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z18_11970	COG1280	lysine exporter protein (LysE YggA)
L2Z18_11975	COG2837	iron assimilation
L2Z18_11985	COG0281	malic enzyme
L2Z18_12030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z18_12030	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z18_12035	COG4399	Belongs to the UPF0754 family
L2Z18_12040	COG2259	Doxx family
L2Z18_12045	COG0586	Pfam SNARE associated Golgi protein
L2Z18_12060	COG1192	Involved in chromosome partitioning
L2Z18_12070	COG0271	Belongs to the BolA IbaG family
L2Z18_12090	COG2267	carboxylic ester hydrolase activity
L2Z18_12110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z18_12110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z18_12110	COG3321	synthase
L2Z18_12110	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z18_12115	COG1960	acyl-CoA dehydrogenase activity
L2Z18_12125	COG2197	response regulator
L2Z18_12135	COG3916	Acyl-homoserine-lactone synthase
L2Z18_12140	COG0477	Major facilitator Superfamily
L2Z18_12145	COG1024	Enoyl-CoA hydratase
L2Z18_12150	COG1024	Enoyl-CoA hydratase
L2Z18_12155	COG1960	acyl-CoA dehydrogenase activity
L2Z18_12160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z18_12180	COG1113	amino acid transport
L2Z18_12185	COG1113	amino acid transport
L2Z18_12190	COG0251	oxidation-reduction process
L2Z18_12230	COG0564	pseudouridine synthase activity
L2Z18_12290	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z18_12305	COG1802	Transcriptional regulator
L2Z18_12315	COG1448	Aminotransferase
L2Z18_12320	COG0277	FAD linked oxidase domain protein
L2Z18_12330	COG2186	Transcriptional regulator
L2Z18_12340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z18_12345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z18_12360	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z18_12365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z18_12370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z18_12430	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z18_12435	COG1596	polysaccharide export
L2Z18_12460	COG0728	peptidoglycan biosynthetic process
L2Z18_12465	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z18_12520	COG0546	phosphoglycolate phosphatase activity
L2Z18_12525	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_12545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z18_12550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z18_12555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z18_12560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z18_12565	COG1116	anion transmembrane transporter activity
L2Z18_12570	COG1309	transcriptional regulator
L2Z18_12575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z18_12585	COG0196	riboflavin kinase activity
L2Z18_12590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z18_12600	COG1047	Peptidyl-prolyl cis-trans
L2Z18_12640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z18_12645	COG0657	acetylesterase activity
L2Z18_12665	COG0583	DNA-binding transcription factor activity
L2Z18_12695	COG2951	lytic endotransglycosylase activity
L2Z18_12700	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z18_12715	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z18_12725	COG0671	phosphoesterase, PA-phosphatase related
L2Z18_12730	COG0861	Integral membrane protein TerC family
L2Z18_12740	COG0754	glutathionylspermidine amidase activity
L2Z18_12750	COG0402	S-adenosylhomocysteine deaminase activity
L2Z18_12765	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z18_12770	COG1230	cation diffusion facilitator family transporter
L2Z18_12785	COG0706	membrane insertase activity
L2Z18_12810	COG0592	DNA-directed DNA polymerase activity
L2Z18_12820	COG0187	DNA topoisomerase II activity
L2Z18_12830	COG0586	Pfam SNARE associated Golgi protein
L2Z18_12835	COG0488	(ABC) transporter
L2Z18_12865	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z18_12870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z18_12910	COG0733	neurotransmitter:sodium symporter activity
L2Z18_12950	COG2233	PERMEase
L2Z18_12965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z18_13000	COG2814	Major facilitator Superfamily
L2Z18_13005	COG0656	L-ascorbic acid biosynthetic process
L2Z18_13010	COG0583	DNA-binding transcription factor activity
L2Z18_13025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z18_13030	COG1064	alcohol dehydrogenase
L2Z18_13035	COG2818	Glycosylase
L2Z18_13050	COG1194	a g-specific adenine glycosylase
L2Z18_13070	COG2983	Belongs to the UPF0260 family
L2Z18_13075	COG2133	pyrroloquinoline quinone binding
L2Z18_13080	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z18_13085	COG2116	formate transmembrane transporter activity
L2Z18_13105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z18_13110	COG1335	isochorismatase
L2Z18_13115	COG0385	Bile acid
L2Z18_13120	COG0534	Mate efflux family protein
L2Z18_13125	COG1683	Conserved Protein
L2Z18_13145	COG0625	glutathione transferase activity
L2Z18_13155	COG1113	amino acid transport
L2Z18_13165	COG0523	cobalamin synthesis protein
L2Z18_13175	COG2188	Transcriptional regulator
L2Z18_13205	COG0010	Belongs to the arginase family
L2Z18_13220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z18_13225	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z18_13235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z18_13240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z18_13340	COG0534	Mate efflux family protein
L2Z18_13345	COG0436	Aminotransferase
L2Z18_13350	COG2733	membrane
L2Z18_13365	COG2918	glutathione biosynthetic process
L2Z18_13380	COG0791	NLP P60 protein
L2Z18_13380	COG1388	LysM domain
L2Z18_13395	COG3150	esterase
L2Z18_13405	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_13410	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z18_13420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z18_13430	COG2233	PERMEase
L2Z18_13435	COG2351	hydroxyisourate hydrolase activity
L2Z18_13470	COG3706	GGDEF domain
L2Z18_13485	COG1393	Belongs to the ArsC family
L2Z18_13490	COG0708	Exodeoxyribonuclease III
L2Z18_13510	COG0189	ligase activity
L2Z18_13530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z18_13540	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z18_13555	COG4942	peptidase
L2Z18_13565	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z18_13575	COG2119	membrane
L2Z18_13580	COG4774	siderophore transport
L2Z18_13585	COG0426	domain, Protein
L2Z18_13585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z18_13610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z18_13630	COG1902	pentaerythritol trinitrate reductase activity
L2Z18_13635	COG1519	Transferase
L2Z18_13640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z18_13645	COG0668	transmembrane transport
L2Z18_13655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z18_13660	COG1335	isochorismatase
L2Z18_13665	COG1522	sequence-specific DNA binding
L2Z18_13670	COG3328	transposase activity
L2Z18_13695	COG0784	Response regulator, receiver
L2Z18_13695	COG2198	Histidine kinase
L2Z18_13695	COG2205	protein histidine kinase activity
L2Z18_13700	COG3162	membrane
L2Z18_13705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z18_13715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z18_13735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z18_13740	COG1309	transcriptional regulator
L2Z18_13760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z18_13760	COG0351	phosphomethylpyrimidine kinase
L2Z18_13760	COG0352	thiamine-phosphate diphosphorylase activity
L2Z18_13770	COG2814	Major facilitator Superfamily
L2Z18_13785	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z18_13795	COG1113	amino acid transport
L2Z18_13805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z18_13810	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_13820	COG1335	isochorismatase
L2Z18_13850	COG2814	Major facilitator Superfamily
L2Z18_13855	COG0583	DNA-binding transcription factor activity
L2Z18_13875	COG0667	Aldo Keto reductase
L2Z18_13910	COG1733	regulation of RNA biosynthetic process
L2Z18_13915	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z18_13980	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z18_13995	COG2329	Antibiotic biosynthesis monooxygenase
L2Z18_14025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z18_14055	COG0427	acetyl-CoA hydrolase
L2Z18_14080	COG0659	secondary active sulfate transmembrane transporter activity
L2Z18_14085	COG4221	oxidoreductase activity
L2Z18_14090	COG2873	o-acetylhomoserine
L2Z18_14095	COG0488	(ABC) transporter
L2Z18_14180	COG0833	amino acid
L2Z18_14225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z18_14230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z18_14245	COG2226	methyltransferase
L2Z18_14295	COG0067	glutamate synthase
L2Z18_14295	COG0069	glutamate synthase activity
L2Z18_14295	COG0070	glutamate synthase
L2Z18_14300	COG0493	'glutamate synthase
L2Z18_14310	COG1704	LemA family
L2Z18_14315	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z18_14335	COG3307	-O-antigen
L2Z18_14355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z18_14370	COG0194	GDP metabolic process
L2Z18_14420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z18_14440	COG5380	lipid catabolic process
L2Z18_14445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z18_14470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z18_14475	COG0277	FAD linked oxidase domain protein
L2Z18_14485	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z18_14490	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z18_14505	COG1289	transmembrane transporter activity
L2Z18_14515	COG0628	permease
L2Z18_14520	COG1192	Involved in chromosome partitioning
L2Z18_14550	COG0833	amino acid
L2Z18_14555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z18_14560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z18_14570	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_14610	COG0583	DNA-binding transcription factor activity
L2Z18_14655	COG0517	IMP dehydrogenase activity
L2Z18_14660	COG1983	PspC domain protein
L2Z18_14670	COG1960	acyl-CoA dehydrogenase activity
L2Z18_14685	COG0408	coproporphyrinogen oxidase activity
L2Z18_14705	COG0513	Belongs to the DEAD box helicase family
L2Z18_14715	COG1127	ABC transporter
L2Z18_14720	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z18_14730	COG2854	intermembrane phospholipid transfer
L2Z18_14740	COG0598	Magnesium transport protein CorA
L2Z18_14750	COG0494	nUDIX hydrolase
L2Z18_14755	COG1040	competence protein
L2Z18_14760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z18_14780	COG1946	Acyl-CoA thioesterase
L2Z18_14785	COG1301	dicarboxylic acid transport
L2Z18_14800	COG1959	2 iron, 2 sulfur cluster binding
L2Z18_14805	COG1017	nitric oxide dioxygenase activity
L2Z18_14805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z18_14810	COG0433	COG0433 Predicted ATPase
L2Z18_14815	COG0626	cystathionine gamma-synthase activity
L2Z18_14970	COG1960	acyl-CoA dehydrogenase activity
L2Z18_14975	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z18_15005	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z18_15010	COG0339	signal peptide processing
L2Z18_15015	COG0557	exoribonuclease II activity
L2Z18_15060	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z18_15065	COG2169	Transcriptional regulator
L2Z18_15070	COG0697	spore germination
L2Z18_15075	COG1295	ribonuclease BN
L2Z18_15110	COG1702	phosphate starvation-inducible protein PhoH
L2Z18_15120	COG0739	heme binding
L2Z18_15120	COG1196	nuclear chromosome segregation
L2Z18_15120	COG0741	lytic transglycosylase activity
L2Z18_15150	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z18_15155	COG1183	phosphatidylcholine synthase activity
L2Z18_15200	COG1960	acyl-CoA dehydrogenase activity
L2Z18_15205	COG1309	transcriptional regulator
L2Z18_15220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z18_15225	COG1960	acyl-CoA dehydrogenase activity
L2Z18_15245	COG2969	positive regulation of protein catabolic process
L2Z18_15255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z18_15270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z18_15275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z18_15295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z18_15305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z18_15310	COG1408	metallophosphoesterase
L2Z18_15320	COG2199	diguanylate cyclase activity
L2Z18_15380	COG1607	acyl-coa hydrolase
L2Z18_15410	COG2350	Protein conserved in bacteria
L2Z18_15420	COG0613	PHP domain protein
L2Z18_15425	COG3781	membrane
L2Z18_15435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z18_15440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z18_15450	COG1862	Preprotein translocase
L2Z18_15480	COG2205	protein histidine kinase activity
L2Z18_15485	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z18_15505	COG0726	polysaccharide deacetylase
L2Z18_15510	COG0463	Glycosyl transferase, family 2
L2Z18_15515	COG0438	transferase activity, transferring glycosyl groups
L2Z18_15580	COG0625	glutathione transferase activity
L2Z18_15585	COG0583	DNA-binding transcription factor activity
L2Z18_15590	COG1960	acyl-CoA dehydrogenase activity
L2Z18_15595	COG1960	acyl-CoA dehydrogenase activity
L2Z18_15605	COG2205	protein histidine kinase activity
L2Z18_15610	COG0745	RESPONSE REGULATOR receiver
L2Z18_15615	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z18_15635	COG2096	Adenosyltransferase
L2Z18_15685	COG0285	dihydrofolate synthase activity
L2Z18_15705	COG0450	alkyl hydroperoxide reductase
L2Z18_15720	COG0477	Major facilitator Superfamily
L2Z18_15725	COG1272	protein, Hemolysin III
L2Z18_15755	COG0183	Belongs to the thiolase family
L2Z18_15760	COG2207	Transcriptional regulator
L2Z18_15780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z18_15800	COG0183	Belongs to the thiolase family
L2Z18_15810	COG2885	chlorophyll binding
L2Z18_15810	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z18_15820	COG1690	Belongs to the RtcB family
L2Z18_15825	COG0833	amino acid
L2Z18_15835	COG2233	PERMEase
L2Z18_15840	COG1217	gtp-binding protein TYPA
L2Z18_15865	COG2094	Belongs to the DNA glycosylase MPG family
L2Z18_15885	COG1902	pentaerythritol trinitrate reductase activity
L2Z18_15900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z18_15905	COG0354	folic acid binding
L2Z18_15915	COG3189	MarR family transcriptional regulator
L2Z18_15920	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z18_15925	COG3422	double-strand break repair
L2Z18_15965	COG0840	transmembrane signaling receptor activity
L2Z18_15985	COG5510	response to toxic substance
L2Z18_15995	COG2832	Protein of unknown function (DUF454)
L2Z18_16000	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z18_16040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z18_16050	COG1289	transmembrane transporter activity
L2Z18_16055	COG2814	Major facilitator Superfamily
L2Z18_16075	COG1115	amino acid carrier protein
L2Z18_16080	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z18_16085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z18_16090	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z18_16130	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z18_16140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z18_16145	COG1077	Cell shape determining protein MreB Mrl
L2Z18_16150	COG1792	Involved in formation and maintenance of cell shape
L2Z18_16155	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z18_16160	COG0424	maF-like protein
L2Z18_16165	COG1530	ribonuclease E activity
L2Z18_16175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z18_16185	COG0560	Phosphoserine phosphatase
L2Z18_16195	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z18_16220	COG2207	Transcriptional regulator
L2Z18_16240	COG1113	amino acid transport
L2Z18_16245	COG2828	Protein conserved in bacteria
L2Z18_16250	COG0142	geranyltranstransferase activity
L2Z18_16255	COG2315	Protein conserved in bacteria
L2Z18_16270	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z18_16290	COG2194	sulfuric ester hydrolase activity
L2Z18_16295	COG0745	RESPONSE REGULATOR receiver
L2Z18_16300	COG0642	Histidine kinase
L2Z18_16310	COG0004	ammonium transporteR
L2Z18_16315	COG0583	DNA-binding transcription factor activity
L2Z18_16335	COG0525	valine-tRNA ligase activity
L2Z18_16345	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z18_16355	COG0393	Putative heavy-metal-binding
L2Z18_16360	COG0393	Putative heavy-metal-binding
L2Z18_16365	COG1538	Outer membrane efflux protein
L2Z18_16375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z18_16380	COG0671	phosphoesterase, PA-phosphatase related
L2Z18_16410	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z18_16425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z18_16425	COG1648	precorrin-2 dehydrogenase activity
L2Z18_16430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z18_16435	COG1733	regulation of RNA biosynthetic process
L2Z18_16445	COG0531	amino acid
L2Z18_16460	COG0321	lipoyl(octanoyl) transferase activity
L2Z18_16465	COG2921	Belongs to the UPF0250 family
L2Z18_16505	COG2009	succinate dehydrogenase
L2Z18_16510	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z18_16515	COG1053	succinate dehydrogenase
L2Z18_16520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z18_16545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z18_16565	COG2354	Protein conserved in bacteria
L2Z18_16570	COG2321	neutral zinc metallopeptidase
L2Z18_16590	COG2843	Capsule synthesis protein
L2Z18_16605	COG0589	response to stress
L2Z18_16625	COG0505	Belongs to the CarA family
L2Z18_16650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z18_16655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z18_16705	COG0477	Major facilitator Superfamily
L2Z18_16710	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z18_16725	COG1597	lipid kinase activity
L2Z18_16730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z18_16760	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z18_16780	COG0741	lytic transglycosylase activity
L2Z18_16800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z18_16815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z18_16850	COG0778	Nitroreductase
L2Z18_16865	COG1929	Belongs to the glycerate kinase type-1 family
L2Z18_16870	COG0243	molybdopterin cofactor binding
L2Z18_16875	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z18_16880	COG3339	Conserved Protein
L2Z18_16890	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z18_16905	COG1113	amino acid transport
L2Z18_16915	COG0019	diaminopimelate decarboxylase activity
L2Z18_16925	COG1280	lysine exporter protein (LysE YggA)
L2Z18_16930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z18_16960	COG0463	Glycosyl transferase, family 2
L2Z18_16980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z18_17015	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z18_17020	COG1136	(ABC) transporter
L2Z18_17025	COG0658	competence protein
L2Z18_17025	COG2333	competence protein COMEC
L2Z18_17035	COG0616	signal peptide processing
L2Z18_17035	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z18_17040	COG0596	Alpha beta hydrolase
L2Z18_17045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z18_17055	COG0628	permease
L2Z18_17100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z18_17120	COG0823	Involved in the tonB-independent uptake of proteins
L2Z18_17140	COG0824	Thioesterase
L2Z18_17145	COG1473	amidohydrolase
L2Z18_17165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z18_17165	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z18_17170	COG2814	Major facilitator Superfamily
L2Z18_17180	COG1024	Enoyl-CoA hydratase
L2Z18_17185	COG1056	cytidyltransferase-related domain
L2Z18_17185	COG1051	belongs to the nudix hydrolase family
L2Z18_17195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z18_17210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z18_17225	COG4625	pathogenesis
L2Z18_17230	COG0583	DNA-binding transcription factor activity
L2Z18_17235	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z18_17240	COG4208	sulfate ABC transporter
L2Z18_17245	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z18_17255	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z18_17260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z18_17265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z18_17285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z18_17300	COG0681	Belongs to the peptidase S26 family
L2Z18_17315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z18_17325	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z18_17330	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z18_17340	COG4221	oxidoreductase activity
L2Z18_17370	COG0436	Aminotransferase
L2Z18_17400	COG0556	nucleotide-excision repair
L2Z18_17455	COG2070	2-Nitropropane dioxygenase
L2Z18_17485	COG1215	transferase activity, transferring glycosyl groups
L2Z18_17500	COG0415	Belongs to the DNA photolyase family
L2Z18_17510	COG1252	NADH dehydrogenase
L2Z18_17515	COG1686	Belongs to the peptidase S11 family
L2Z18_17530	COG1187	pseudouridine synthase activity
L2Z18_17555	COG0477	Major facilitator Superfamily
L2Z18_17560	COG0583	DNA-binding transcription factor activity
L2Z18_17565	COG1823	symporter activity
L2Z18_17575	COG0612	Peptidase, M16
L2Z18_17600	COG0352	thiamine-phosphate diphosphorylase activity
L2Z18_17635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z18_17650	COG1309	transcriptional regulator
L2Z18_17660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z18_17665	COG0076	glutamate decarboxylase activity
L2Z18_17675	COG1522	sequence-specific DNA binding
L2Z18_17680	COG3961	Belongs to the TPP enzyme family
L2Z18_17685	COG1113	amino acid transport
L2Z18_17690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z18_17695	COG0573	inorganic phosphate transmembrane transporter activity
L2Z18_17705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z18_17710	COG0616	signal peptide processing
L2Z18_17720	COG3328	transposase activity
L2Z18_17750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z18_17755	COG1686	Belongs to the peptidase S11 family
L2Z18_17780	COG0583	DNA-binding transcription factor activity
L2Z18_17785	COG1067	ATP-dependent peptidase activity
L2Z18_17830	COG1966	Carbon starvation protein
L2Z18_17835	COG2879	small protein
L2Z18_17870	COG2508	Transcriptional regulator
L2Z18_17870	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z18_17890	COG1113	amino acid transport
L2Z18_17895	COG0583	DNA-binding transcription factor activity
L2Z18_17900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z18_17905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z18_17915	COG1012	belongs to the aldehyde dehydrogenase family
L2Z18_17925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z18_17930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z18_17930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z18_17965	COG2814	Major facilitator Superfamily
L2Z18_17970	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z18_17980	COG1309	transcriptional regulator
L2Z18_18000	COG1741	Belongs to the pirin family
L2Z18_18010	COG2964	Protein conserved in bacteria
L2Z18_18025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z18_18030	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z18_18035	COG4605	iron ion homeostasis
L2Z18_18040	COG4604	ABC transporter, ATP-binding protein
L2Z18_18045	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z18_18050	COG4774	siderophore transport
L2Z18_18060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z18_18065	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z18_18070	COG1535	isochorismatase
L2Z18_18070	COG3433	isochorismatase activity
L2Z18_18085	COG1132	(ABC) transporter
L2Z18_18090	COG1132	(ABC) transporter
L2Z18_18095	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z18_18105	COG1169	isochorismate synthase
L2Z18_18120	COG3739	integral membrane protein
L2Z18_18145	COG0302	gtp cyclohydrolase
L2Z18_18155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z18_18185	COG0308	aminopeptidase N
L2Z18_18190	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z18_18380	COG5410	chromosome segregation
L2Z18_18480	COG1598	PFAM Uncharacterised protein family UPF0150
L2Z18_18575	COG0582	viral genome integration into host DNA
L2Z18_18590	COG0174	glutamine synthetase
L2Z18_18600	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z18_18635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z18_18640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z18_18645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z18_18665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z18_18670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z18_18675	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z18_18690	COG1960	acyl-CoA dehydrogenase activity
L2Z18_18695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z18_18700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z18_18710	COG2223	nitrite transmembrane transporter activity
L2Z18_18720	COG0024	Methionine aminopeptidase
L2Z18_18725	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z18_18740	COG2207	Transcriptional regulator
L2Z18_18765	COG2951	lytic endotransglycosylase activity
L2Z18_18770	COG0772	Belongs to the SEDS family
L2Z18_18785	COG0842	Transport permease protein
L2Z18_18790	COG1131	(ABC) transporter
L2Z18_18835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z18_18850	COG4215	(ABC) transporter
L2Z18_18855	COG4160	amino acid transport
L2Z18_18860	COG4598	ABC transporter
L2Z18_18870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z18_18875	COG0826	peptidase U32
L2Z18_18880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z18_18895	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z18_18905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z18_18920	COG0642	Histidine kinase
L2Z18_18930	COG0494	nUDIX hydrolase
L2Z18_18940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z18_18945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z18_18950	COG3139	Protein of unknown function (DUF1315)
L2Z18_18955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z18_18960	COG1301	dicarboxylic acid transport
L2Z18_18965	COG1960	acyl-CoA dehydrogenase activity
L2Z18_18970	COG2819	hydrolase of the alpha beta superfamily
L2Z18_18980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z18_18990	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z18_18995	COG1234	tRNA 3'-trailer cleavage
L2Z18_19025	COG2363	Small membrane protein
L2Z18_19050	COG0513	Belongs to the DEAD box helicase family
L2Z18_19060	COG0778	Nitroreductase
L2Z18_19090	COG1286	toxin biosynthetic process
L2Z18_19115	COG4783	chaperone-mediated protein folding
L2Z18_19120	COG1610	YqeY-like protein
L2Z18_19220	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z18_19245	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z18_19250	COG0786	glutamate:sodium symporter activity
L2Z18_19260	COG2186	Transcriptional regulator