locus-tag	class	description
L2Z21_00020	COG0302	gtp cyclohydrolase
L2Z21_00030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z21_00065	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z21_00080	COG0174	glutamine synthetase
L2Z21_00090	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z21_00125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z21_00130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z21_00140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z21_00160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z21_00165	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z21_00170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z21_00185	COG1960	acyl-CoA dehydrogenase activity
L2Z21_00190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z21_00195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z21_00205	COG2223	nitrite transmembrane transporter activity
L2Z21_00215	COG0024	Methionine aminopeptidase
L2Z21_00220	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z21_00235	COG2207	Transcriptional regulator
L2Z21_00260	COG2951	lytic endotransglycosylase activity
L2Z21_00265	COG0772	Belongs to the SEDS family
L2Z21_00280	COG0842	Transport permease protein
L2Z21_00285	COG1131	(ABC) transporter
L2Z21_00330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_00345	COG4215	(ABC) transporter
L2Z21_00350	COG4160	amino acid transport
L2Z21_00355	COG4598	ABC transporter
L2Z21_00365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z21_00370	COG0826	peptidase U32
L2Z21_00375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z21_00390	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z21_00400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z21_00415	COG0642	Histidine kinase
L2Z21_00425	COG0494	nUDIX hydrolase
L2Z21_00435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z21_00440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z21_00445	COG3139	Protein of unknown function (DUF1315)
L2Z21_00450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z21_00455	COG1301	dicarboxylic acid transport
L2Z21_00460	COG1960	acyl-CoA dehydrogenase activity
L2Z21_00465	COG2819	hydrolase of the alpha beta superfamily
L2Z21_00475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z21_00485	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z21_00490	COG1234	tRNA 3'-trailer cleavage
L2Z21_00520	COG2363	Small membrane protein
L2Z21_00550	COG0513	Belongs to the DEAD box helicase family
L2Z21_00560	COG0778	Nitroreductase
L2Z21_00590	COG1286	toxin biosynthetic process
L2Z21_00615	COG4783	chaperone-mediated protein folding
L2Z21_00620	COG1610	YqeY-like protein
L2Z21_00720	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z21_00745	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z21_00750	COG0786	glutamate:sodium symporter activity
L2Z21_00760	COG2186	Transcriptional regulator
L2Z21_00810	COG0477	Major facilitator Superfamily
L2Z21_00840	COG2985	domain, Protein
L2Z21_00850	COG2995	paraquat-inducible protein a
L2Z21_00855	COG3008	intermembrane lipid transfer
L2Z21_00855	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z21_00865	COG1794	racemase activity, acting on amino acids and derivatives
L2Z21_00895	COG1301	dicarboxylic acid transport
L2Z21_00905	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z21_00910	COG2011	ABC-type metal ion transport system permease component
L2Z21_00915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z21_00920	COG1464	Belongs to the NlpA lipoprotein family
L2Z21_00925	COG0151	Belongs to the GarS family
L2Z21_00930	COG0138	bifunctional purine biosynthesis protein purh
L2Z21_00935	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z21_00965	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z21_00975	COG1305	Transglutaminase-like
L2Z21_00985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z21_00990	COG0305	Participates in initiation and elongation during chromosome replication
L2Z21_01020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z21_01030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z21_01035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z21_01060	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z21_01060	COG0726	polysaccharide deacetylase
L2Z21_01065	COG1215	transferase activity, transferring glycosyl groups
L2Z21_01070	COG3658	cytochrome
L2Z21_01080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z21_01095	COG0583	DNA-binding transcription factor activity
L2Z21_01115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z21_01120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z21_01135	COG1960	acyl-CoA dehydrogenase activity
L2Z21_01140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z21_01145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_01170	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z21_01175	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z21_01185	COG2205	protein histidine kinase activity
L2Z21_01190	COG0745	RESPONSE REGULATOR receiver
L2Z21_01195	COG0174	glutamine synthetase
L2Z21_01215	COG0729	surface antigen
L2Z21_01240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z21_01245	COG2814	Major facilitator Superfamily
L2Z21_01260	COG0583	DNA-binding transcription factor activity
L2Z21_01275	COG1187	pseudouridine synthase activity
L2Z21_01295	COG0802	atpase or kinase
L2Z21_01300	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z21_01310	COG1923	regulation of RNA biosynthetic process
L2Z21_01315	COG0697	spore germination
L2Z21_01330	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z21_01340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z21_01345	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z21_01345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z21_01350	COG4302	ethanolamine ammonia-lyase activity
L2Z21_01355	COG4303	Ethanolamine ammonia lyase large subunit
L2Z21_01360	COG0531	amino acid
L2Z21_01380	COG1454	alcohol dehydrogenase
L2Z21_01385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z21_01395	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z21_01415	COG0308	aminopeptidase N
L2Z21_01425	COG4221	oxidoreductase activity
L2Z21_01435	COG1605	Chorismate mutase
L2Z21_01455	COG1309	transcriptional regulator
L2Z21_01465	COG0668	transmembrane transport
L2Z21_01495	COG4773	Receptor
L2Z21_01515	COG0488	(ABC) transporter
L2Z21_01520	COG0589	response to stress
L2Z21_01545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z21_01555	COG3135	benzoate transporter
L2Z21_01560	COG1522	sequence-specific DNA binding
L2Z21_01570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z21_01575	COG0583	DNA-binding transcription factor activity
L2Z21_01585	COG0183	Belongs to the thiolase family
L2Z21_01595	COG2030	dehydratase
L2Z21_01600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z21_01615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z21_01625	COG0824	Thioesterase
L2Z21_01630	COG1454	alcohol dehydrogenase
L2Z21_01640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z21_01660	COG0069	glutamate synthase activity
L2Z21_01680	COG2814	Major facilitator Superfamily
L2Z21_01695	COG0511	ligase activity, forming carbon-carbon bonds
L2Z21_01715	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z21_01715	COG1116	anion transmembrane transporter activity
L2Z21_01720	COG0745	RESPONSE REGULATOR receiver
L2Z21_01730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_01730	COG2146	nitrite reductase [NAD(P)H] activity
L2Z21_01735	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_01740	COG0243	molybdopterin cofactor binding
L2Z21_01750	COG0243	molybdopterin cofactor binding
L2Z21_01755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z21_01770	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z21_01770	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z21_01775	COG0303	'Molybdopterin
L2Z21_01785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z21_01790	COG0697	spore germination
L2Z21_01810	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z21_01880	COG2204	response regulator
L2Z21_01885	COG3852	Histidine kinase
L2Z21_01905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z21_01910	COG0575	Belongs to the CDS family
L2Z21_01945	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z21_01960	COG2137	regulation of response to DNA damage stimulus
L2Z21_01970	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z21_01975	COG1011	Hydrolase
L2Z21_02000	COG1522	sequence-specific DNA binding
L2Z21_02010	COG1113	amino acid transport
L2Z21_02030	COG0659	secondary active sulfate transmembrane transporter activity
L2Z21_02035	COG2135	peptidase activity
L2Z21_02045	COG4372	Transposase
L2Z21_02065	COG3300	MHYT domain
L2Z21_02065	COG5001	Diguanylate cyclase
L2Z21_02085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z21_02085	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z21_02085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z21_02090	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z21_02095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z21_02095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z21_02125	COG0024	Methionine aminopeptidase
L2Z21_02130	COG0583	DNA-binding transcription factor activity
L2Z21_02140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z21_02145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z21_02150	COG0516	GMP reductase activity
L2Z21_02150	COG0517	IMP dehydrogenase activity
L2Z21_02175	COG0552	protein localization to endoplasmic reticulum
L2Z21_02185	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z21_02200	COG4890	Cyd operon protein YbgT
L2Z21_02205	COG1294	oxidase, subunit
L2Z21_02220	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z21_02230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z21_02235	COG4774	siderophore transport
L2Z21_02250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z21_02255	COG0569	domain protein
L2Z21_02260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z21_02290	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z21_02295	COG0542	response to heat
L2Z21_02320	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_02320	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_02365	COG2323	membrane
L2Z21_02370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z21_02380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z21_02385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z21_02390	COG0183	Belongs to the thiolase family
L2Z21_02395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z21_02400	COG0596	Alpha beta hydrolase
L2Z21_02405	COG2271	Major facilitator Superfamily
L2Z21_02410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z21_02415	COG3485	protocatechuate 3,4-dioxygenase
L2Z21_02420	COG3485	protocatechuate 3,4-dioxygenase
L2Z21_02425	COG0710	3-dehydroquinate dehydratase activity
L2Z21_02430	COG3420	alginic acid biosynthetic process
L2Z21_02435	COG3659	wide pore channel activity
L2Z21_02440	COG4993	Dehydrogenase
L2Z21_02450	COG2391	methyltransferase activity
L2Z21_02465	COG1414	Transcriptional regulator
L2Z21_02470	COG0583	DNA-binding transcription factor activity
L2Z21_02475	COG1960	acyl-CoA dehydrogenase activity
L2Z21_02500	COG2814	Major facilitator Superfamily
L2Z21_02510	COG0154	amidase activity
L2Z21_02530	COG4638	Rieske (2fe-2S)
L2Z21_02540	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_02550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_02560	COG3733	amine oxidase
L2Z21_02570	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_02580	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z21_02585	COG0183	Belongs to the thiolase family
L2Z21_02590	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z21_02595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z21_02605	COG4829	muconolactone delta-isomerase
L2Z21_02610	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z21_02615	COG0583	DNA-binding transcription factor activity
L2Z21_02625	COG2186	Transcriptional regulator
L2Z21_02645	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_02665	COG1960	acyl-CoA dehydrogenase activity
L2Z21_02670	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_02685	COG3162	membrane
L2Z21_02700	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_02715	COG0753	catalase activity
L2Z21_02740	COG1846	Transcriptional regulator
L2Z21_02745	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_02745	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_02755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z21_02785	COG1309	transcriptional regulator
L2Z21_02795	COG1335	isochorismatase
L2Z21_02800	COG0583	DNA-binding transcription factor activity
L2Z21_02810	COG0475	glutathione-regulated potassium exporter activity
L2Z21_02810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z21_02820	COG1473	amidohydrolase
L2Z21_02835	COG4372	Transposase
L2Z21_02855	COG3210	domain, Protein
L2Z21_02885	COG2188	Transcriptional regulator
L2Z21_02900	COG0583	DNA-binding transcription factor activity
L2Z21_02930	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z21_02960	COG1566	PFAM secretion protein HlyD family protein
L2Z21_02975	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_02980	COG0129	dihydroxy-acid dehydratase activity
L2Z21_02990	COG0583	DNA-binding transcription factor activity
L2Z21_02995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z21_03005	COG2084	Dehydrogenase
L2Z21_03010	COG2207	Transcriptional regulator
L2Z21_03025	COG1064	alcohol dehydrogenase
L2Z21_03035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z21_03040	COG1120	ATPase activity
L2Z21_03060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z21_03180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z21_03195	COG3293	Transposase
L2Z21_03240	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_03255	COG2207	Transcriptional regulator
L2Z21_03265	COG2205	protein histidine kinase activity
L2Z21_03270	COG0745	RESPONSE REGULATOR receiver
L2Z21_03275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_03280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z21_03285	COG1538	Outer membrane efflux protein
L2Z21_03295	COG2072	flavoprotein involved in K transport
L2Z21_03315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z21_03330	COG3539	Fimbrial protein
L2Z21_03355	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z21_03365	COG0753	catalase activity
L2Z21_03380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z21_03440	COG1535	isochorismatase
L2Z21_03440	COG3433	isochorismatase activity
L2Z21_03445	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_03450	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z21_03455	COG4149	molybdate abc transporter
L2Z21_03460	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z21_03470	COG4638	Rieske (2fe-2S)
L2Z21_03475	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z21_03480	COG0543	2 iron, 2 sulfur cluster binding
L2Z21_03480	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z21_03505	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_03520	COG2207	Transcriptional regulator
L2Z21_03525	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_03530	COG2610	gluconate transmembrane transporter activity
L2Z21_03540	COG0583	DNA-binding transcription factor activity
L2Z21_03550	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z21_03555	COG2031	fatty acid transporter
L2Z21_03560	COG0183	Belongs to the thiolase family
L2Z21_03565	COG0583	DNA-binding transcription factor activity
L2Z21_03570	COG0583	DNA-binding transcription factor activity
L2Z21_03585	COG1027	Aspartate ammonia-lyase
L2Z21_03595	COG0477	Major facilitator Superfamily
L2Z21_03615	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z21_03620	COG4521	taurine ABC transporter
L2Z21_03635	COG2188	Transcriptional regulator
L2Z21_03645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z21_03650	COG1733	regulation of RNA biosynthetic process
L2Z21_03655	COG2207	Transcriptional regulator
L2Z21_03655	COG3708	Transcriptional regulator
L2Z21_03670	COG0730	response to heat
L2Z21_03685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z21_03685	COG3453	Protein conserved in bacteria
L2Z21_03695	COG3781	membrane
L2Z21_03700	COG1063	alcohol dehydrogenase
L2Z21_03710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z21_03715	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z21_03720	COG0022	dehydrogenase e1 component
L2Z21_03725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z21_03730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z21_03745	COG3706	GGDEF domain
L2Z21_03760	COG0133	tryptophan synthase activity
L2Z21_03770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z21_03805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z21_03830	COG2226	methyltransferase
L2Z21_03885	COG0842	Transport permease protein
L2Z21_03890	COG0842	Transport permease protein
L2Z21_03895	COG1131	(ABC) transporter
L2Z21_03910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z21_03915	COG4773	Receptor
L2Z21_03935	COG0730	response to heat
L2Z21_03940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z21_03960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z21_03975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z21_04015	COG4264	IucA IucC family
L2Z21_04020	COG4264	IucA IucC family
L2Z21_04040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z21_04055	COG1960	acyl-CoA dehydrogenase activity
L2Z21_04060	COG1960	acyl-CoA dehydrogenase activity
L2Z21_04065	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z21_04070	COG2207	Transcriptional regulator
L2Z21_04075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z21_04080	COG0776	regulation of translation
L2Z21_04105	COG0822	iron-sulfur transferase activity
L2Z21_04110	COG0316	Belongs to the HesB IscA family
L2Z21_04140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z21_04160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z21_04165	COG0702	epimerase
L2Z21_04200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z21_04210	COG0339	signal peptide processing
L2Z21_04260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z21_04265	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z21_04295	COG0776	regulation of translation
L2Z21_04360	COG0084	hydrolase, TatD family'
L2Z21_04380	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z21_04385	COG1132	(ABC) transporter
L2Z21_04395	COG0811	peptide transport
L2Z21_04400	COG1475	DNA binding
L2Z21_04405	COG1192	Involved in chromosome partitioning
L2Z21_04415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z21_04430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z21_04435	COG0191	fructose-bisphosphate aldolase activity
L2Z21_04455	COG0424	maF-like protein
L2Z21_04460	COG2850	peptidyl-arginine hydroxylation
L2Z21_04470	COG0640	Transcriptional regulator
L2Z21_04480	COG3619	membrane
L2Z21_04485	COG3122	Protein conserved in bacteria
L2Z21_04490	COG1132	(ABC) transporter
L2Z21_04510	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z21_04525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z21_04535	COG0506	proline dehydrogenase activity
L2Z21_04535	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z21_04535	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z21_04540	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z21_04555	COG3698	Phosphodiester glycosidase
L2Z21_04565	COG2353	YceI-like domain
L2Z21_04575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z21_04620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z21_04620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z21_04645	COG3539	Fimbrial protein
L2Z21_04650	COG3121	Chaperone
L2Z21_04675	COG0697	spore germination
L2Z21_04685	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z21_04695	COG0583	DNA-binding transcription factor activity
L2Z21_04740	COG1522	sequence-specific DNA binding
L2Z21_04750	COG1126	abc transporter atp-binding protein
L2Z21_04755	COG0765	amino acid transport
L2Z21_04760	COG0765	amino acid transport
L2Z21_04790	COG1464	Belongs to the NlpA lipoprotein family
L2Z21_04800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z21_04805	COG2011	ABC-type metal ion transport system permease component
L2Z21_04810	COG0012	GTP binding
L2Z21_04835	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z21_04875	COG0386	Belongs to the glutathione peroxidase family
L2Z21_04885	COG0436	Aminotransferase
L2Z21_04925	COG3634	alkyl hydroperoxide reductase activity
L2Z21_04940	COG0583	DNA-binding transcription factor activity
L2Z21_04945	COG0798	PFAM Bile acid sodium symporter
L2Z21_04950	COG0640	Transcriptional regulator
L2Z21_04965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z21_04985	COG1953	Uracil, thiamine, allantoin
L2Z21_04995	COG2175	clavaminate synthase activity
L2Z21_05000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z21_05005	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z21_05010	COG4521	taurine ABC transporter
L2Z21_05020	COG0477	Major facilitator Superfamily
L2Z21_05045	COG1271	oxidase subunit
L2Z21_05050	COG1294	oxidase, subunit
L2Z21_05060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z21_05080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z21_05100	COG3052	prosthetic group binding
L2Z21_05105	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z21_05115	COG2814	Major facilitator Superfamily
L2Z21_05135	COG1346	cytolysis
L2Z21_05145	COG0583	DNA-binding transcription factor activity
L2Z21_05150	COG0625	glutathione transferase activity
L2Z21_05155	COG0625	glutathione transferase activity
L2Z21_05160	COG0583	DNA-binding transcription factor activity
L2Z21_05175	COG1045	serine acetyltransferase
L2Z21_05180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z21_05185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z21_05195	COG1280	lysine exporter protein (LysE YggA)
L2Z21_05210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z21_05215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z21_05220	COG1126	abc transporter atp-binding protein
L2Z21_05225	COG0765	amino acid transport
L2Z21_05230	COG0765	amino acid transport
L2Z21_05250	COG2205	protein histidine kinase activity
L2Z21_05250	COG0784	Response regulator, receiver
L2Z21_05270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z21_05290	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_05340	COG0583	DNA-binding transcription factor activity
L2Z21_05360	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z21_05365	COG1309	transcriptional regulator
L2Z21_05370	COG1960	acyl-CoA dehydrogenase activity
L2Z21_05375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z21_05380	COG1024	Enoyl-CoA hydratase
L2Z21_05385	COG4770	biotin carboxylase activity
L2Z21_05395	COG0583	DNA-binding transcription factor activity
L2Z21_05410	COG1960	acyl-CoA dehydrogenase activity
L2Z21_05420	COG2814	Major facilitator Superfamily
L2Z21_05430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z21_05435	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z21_05440	COG2814	Major facilitator Superfamily
L2Z21_05445	COG1960	acyl-CoA dehydrogenase activity
L2Z21_05450	COG1024	Enoyl-CoA hydratase
L2Z21_05455	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_05460	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z21_05465	COG0183	Belongs to the thiolase family
L2Z21_05475	COG2814	Major facilitator Superfamily
L2Z21_05485	COG1024	Enoyl-CoA hydratase
L2Z21_05500	COG1960	acyl-CoA dehydrogenase activity
L2Z21_05505	COG2814	Major facilitator Superfamily
L2Z21_05510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z21_05515	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z21_05530	COG3842	ATPase activity
L2Z21_05535	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z21_05545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_05550	COG1414	Transcriptional regulator
L2Z21_05560	COG0583	DNA-binding transcription factor activity
L2Z21_05565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z21_05570	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_05580	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z21_05590	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_05595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z21_05600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_05605	COG2267	carboxylic ester hydrolase activity
L2Z21_05625	COG3038	cytochrome b561
L2Z21_05630	COG0753	catalase activity
L2Z21_05665	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z21_05675	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z21_05680	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z21_05685	COG0183	Belongs to the thiolase family
L2Z21_05690	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z21_05695	COG1024	Enoyl-CoA hydratase
L2Z21_05700	COG1024	Enoyl-CoA hydratase
L2Z21_05705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z21_05710	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z21_05715	COG3396	Phenylacetate-CoA oxygenase
L2Z21_05720	COG3460	Phenylacetate-CoA oxygenase
L2Z21_05725	COG3396	Phenylacetate-CoA oxygenase
L2Z21_05730	COG2030	dehydratase
L2Z21_05730	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_05735	COG1760	l-serine dehydratase
L2Z21_05740	COG0531	amino acid
L2Z21_05745	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_05760	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_05770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z21_05790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z21_05800	COG0789	Transcriptional regulator
L2Z21_05810	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z21_05825	COG2807	transmembrane transport
L2Z21_05830	COG0590	tRNA wobble adenosine to inosine editing
L2Z21_05950	COG1116	anion transmembrane transporter activity
L2Z21_05955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z21_05965	COG0864	Transcriptional regulator
L2Z21_05985	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z21_05990	COG0439	Biotin carboxylase
L2Z21_06015	COG1309	transcriptional regulator
L2Z21_06035	COG0038	chloride channel
L2Z21_06040	COG4770	biotin carboxylase activity
L2Z21_06060	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z21_06065	COG0583	DNA-binding transcription factor activity
L2Z21_06105	COG4372	Transposase
L2Z21_06135	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z21_06155	COG2814	Major facilitator Superfamily
L2Z21_06170	COG1560	Kdo2-lipid A biosynthetic process
L2Z21_06180	COG5006	permease, DMT superfamily
L2Z21_06185	COG1522	sequence-specific DNA binding
L2Z21_06200	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z21_06210	COG4122	O-methyltransferase activity
L2Z21_06255	COG4372	Transposase
L2Z21_06265	COG1137	ATPase activity
L2Z21_06270	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z21_06280	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z21_06285	COG0517	IMP dehydrogenase activity
L2Z21_06285	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z21_06320	COG2814	Major facilitator Superfamily
L2Z21_06355	COG1278	Cold shock
L2Z21_06390	COG1570	exodeoxyribonuclease VII activity
L2Z21_06440	COG0583	DNA-binding transcription factor activity
L2Z21_06450	COG4638	Rieske (2fe-2S)
L2Z21_06455	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z21_06460	COG0543	2 iron, 2 sulfur cluster binding
L2Z21_06460	COG0633	Ferredoxin
L2Z21_06465	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_06470	COG3135	benzoate transporter
L2Z21_06475	COG2814	Major facilitator Superfamily
L2Z21_06490	COG1643	Atp-dependent helicase
L2Z21_06495	COG0450	alkyl hydroperoxide reductase
L2Z21_06505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z21_06515	COG3634	alkyl hydroperoxide reductase activity
L2Z21_06535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z21_06540	COG0625	glutathione transferase activity
L2Z21_06550	COG2885	chlorophyll binding
L2Z21_06585	COG0542	response to heat
L2Z21_06600	COG1765	OsmC-like protein
L2Z21_06620	COG0667	Aldo Keto reductase
L2Z21_06635	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z21_06645	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z21_06655	COG0527	aspartate kinase activity
L2Z21_06665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z21_06675	COG3038	cytochrome b561
L2Z21_06680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z21_06685	COG2252	PERMEase
L2Z21_06695	COG2072	flavoprotein involved in K transport
L2Z21_06710	COG1741	Belongs to the pirin family
L2Z21_06715	COG1309	transcriptional regulator
L2Z21_06725	COG0300	oxidoreductase activity
L2Z21_06825	COG2186	Transcriptional regulator
L2Z21_06830	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_06840	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z21_06845	COG2271	Major facilitator Superfamily
L2Z21_06850	COG2721	sulfolactate sulfo-lyase activity
L2Z21_06855	COG0697	spore germination
L2Z21_06870	COG1113	amino acid transport
L2Z21_06890	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_06910	COG0531	amino acid
L2Z21_06920	COG1113	amino acid transport
L2Z21_06960	COG3209	COG3209 Rhs family protein
L2Z21_06990	COG4269	membrane
L2Z21_07005	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_07005	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_07015	COG3706	GGDEF domain
L2Z21_07015	COG5001	Diguanylate cyclase
L2Z21_07015	COG4251	negative regulation of phosphorylation
L2Z21_07015	COG2203	Gaf domain
L2Z21_07025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z21_07045	COG4172	Belongs to the ABC transporter superfamily
L2Z21_07050	COG4239	(ABC) transporter, permease
L2Z21_07055	COG4174	ABC transporter (Permease)
L2Z21_07065	COG0741	lytic transglycosylase activity
L2Z21_07065	COG1388	LysM domain
L2Z21_07065	COG0741	lytic transglycosylase activity
L2Z21_07065	COG1388	LysM domain
L2Z21_07070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z21_07110	COG0583	DNA-binding transcription factor activity
L2Z21_07115	COG1279	arginine transmembrane transporter activity
L2Z21_07135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_07140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_07145	COG0006	proline dipeptidase activity
L2Z21_07195	COG4372	Transposase
L2Z21_07200	COG2194	sulfuric ester hydrolase activity
L2Z21_07250	COG0739	heme binding
L2Z21_07575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z21_07600	COG3384	dioxygenase
L2Z21_07610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z21_07615	COG2878	Part of a membrane complex involved in electron transport
L2Z21_07620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z21_07645	COG0768	penicillin binding
L2Z21_07650	COG0742	ribosomal rna small subunit methyltransferase
L2Z21_07665	COG0830	nickel cation binding
L2Z21_07675	COG0804	urea catabolic process
L2Z21_07720	COG1253	flavin adenine dinucleotide binding
L2Z21_07725	COG2851	Citrate transporter
L2Z21_07775	COG1773	rubredoxin
L2Z21_07780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_07790	COG0583	DNA-binding transcription factor activity
L2Z21_07815	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z21_07820	COG4181	ATPase activity
L2Z21_07865	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z21_07885	COG0306	phosphate transporter
L2Z21_07895	COG3958	Transketolase
L2Z21_07900	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z21_07905	COG2271	Major facilitator Superfamily
L2Z21_07910	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_07915	COG0583	DNA-binding transcription factor activity
L2Z21_07930	COG2223	nitrite transmembrane transporter activity
L2Z21_07935	COG2207	Transcriptional regulator
L2Z21_07940	COG2066	Belongs to the glutaminase family
L2Z21_07945	COG0242	peptide deformylase activity
L2Z21_07950	COG0477	Major facilitator Superfamily
L2Z21_07960	COG0028	Belongs to the TPP enzyme family
L2Z21_07975	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_07980	COG2267	carboxylic ester hydrolase activity
L2Z21_07990	COG2271	Major facilitator Superfamily
L2Z21_07995	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z21_08005	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_08025	COG1414	Transcriptional regulator
L2Z21_08040	COG1024	Enoyl-CoA hydratase
L2Z21_08050	COG1215	transferase activity, transferring glycosyl groups
L2Z21_08055	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z21_08055	COG0726	polysaccharide deacetylase
L2Z21_08065	COG4681	YaeQ
L2Z21_08075	COG0523	cobalamin synthesis protein
L2Z21_08085	COG1607	acyl-coa hydrolase
L2Z21_08095	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_08100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_08105	COG1309	transcriptional regulator
L2Z21_08130	COG2040	homocysteine
L2Z21_08135	COG0531	amino acid
L2Z21_08190	COG1595	DNA-templated transcription, initiation
L2Z21_08200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z21_08205	COG0477	Major facilitator Superfamily
L2Z21_08225	COG0084	hydrolase, TatD family'
L2Z21_08275	COG0629	single-stranded DNA binding
L2Z21_08330	COG0582	viral genome integration into host DNA
L2Z21_08340	COG0405	Gamma-glutamyltransferase
L2Z21_08345	COG2814	Major facilitator Superfamily
L2Z21_08355	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z21_08370	COG1090	epimerase
L2Z21_08390	COG0420	3'-5' exonuclease activity
L2Z21_08415	COG0735	belongs to the Fur family
L2Z21_08420	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z21_08440	COG0121	glutamine amidotransferase
L2Z21_08455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z21_08465	COG0210	DNA helicase
L2Z21_08470	COG2885	chlorophyll binding
L2Z21_08475	COG0204	Acyl-transferase
L2Z21_08490	COG2894	cell division
L2Z21_08505	COG1280	lysine exporter protein (LysE YggA)
L2Z21_08510	COG1674	ftsk spoiiie
L2Z21_08510	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z21_08515	COG0492	ferredoxin-NADP+ reductase activity
L2Z21_08520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z21_08530	COG0456	acetyltransferase
L2Z21_08575	COG1981	membrane
L2Z21_08590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z21_08590	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z21_08610	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_08620	COG0657	acetylesterase activity
L2Z21_08630	COG0473	3-isopropylmalate dehydrogenase activity
L2Z21_08635	COG0583	DNA-binding transcription factor activity
L2Z21_08655	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z21_08680	COG0564	pseudouridine synthase activity
L2Z21_08690	COG0358	DNA primase activity
L2Z21_08705	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z21_08735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z21_08765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z21_08775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z21_08775	COG0352	thiamine-phosphate diphosphorylase activity
L2Z21_08775	COG0351	phosphomethylpyrimidine kinase
L2Z21_08780	COG1652	LysM domain
L2Z21_08805	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z21_08810	COG3101	peptidyl-lysine hydroxylation
L2Z21_08815	COG0009	L-threonylcarbamoyladenylate synthase
L2Z21_08820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z21_08825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z21_08840	COG4106	trans-aconitate 2-methyltransferase activity
L2Z21_08855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z21_08855	COG0596	Alpha beta hydrolase
L2Z21_08855	COG2226	methyltransferase
L2Z21_08865	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z21_08870	COG2223	nitrite transmembrane transporter activity
L2Z21_08890	COG1196	nuclear chromosome segregation
L2Z21_08900	COG0730	response to heat
L2Z21_08915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z21_08925	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z21_08975	COG0489	protein tyrosine kinase activity
L2Z21_08985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z21_08985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z21_09015	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z21_09020	COG2081	HI0933 family
L2Z21_09030	COG0668	transmembrane transport
L2Z21_09050	COG0583	DNA-binding transcription factor activity
L2Z21_09075	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z21_09080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z21_09110	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z21_09150	COG0745	RESPONSE REGULATOR receiver
L2Z21_09170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z21_09180	COG0384	phenazine biosynthesis protein PhzF
L2Z21_09200	COG2826	transposase and inactivated derivatives, IS30 family
L2Z21_09215	COG1309	transcriptional regulator
L2Z21_09220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_09235	COG0583	DNA-binding transcription factor activity
L2Z21_09265	COG0583	DNA-binding transcription factor activity
L2Z21_09280	COG0583	DNA-binding transcription factor activity
L2Z21_09285	COG1053	succinate dehydrogenase
L2Z21_09295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z21_09300	COG2814	Major facilitator Superfamily
L2Z21_09305	COG1960	acyl-CoA dehydrogenase activity
L2Z21_09310	COG0583	DNA-binding transcription factor activity
L2Z21_09315	COG1063	alcohol dehydrogenase
L2Z21_09345	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z21_09350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z21_09355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z21_09370	COG3667	copper resistance
L2Z21_09375	COG2132	Multicopper oxidase
L2Z21_09385	COG0561	phosphatase activity
L2Z21_09390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z21_09400	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L2Z21_09415	COG1214	PFAM Peptidase M22, glycoprotease
L2Z21_09465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z21_09475	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z21_09480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z21_09485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z21_09545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z21_09555	COG1846	Transcriptional regulator
L2Z21_09560	COG1764	response to oxidative stress
L2Z21_09600	COG0037	tRNA processing
L2Z21_09610	COG0248	Ppx GppA phosphatase
L2Z21_09640	COG0072	phenylalanine-tRNA ligase activity
L2Z21_09685	COG1238	metal cluster binding
L2Z21_09690	COG0625	glutathione transferase activity
L2Z21_09705	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z21_09710	COG3028	Belongs to the UPF0307 family
L2Z21_09715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z21_09735	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z21_09740	COG0617	tRNA 3'-terminal CCA addition
L2Z21_09745	COG1555	photosystem II stabilization
L2Z21_09750	COG3956	TIGRFAM MazG family protein
L2Z21_09760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z21_09780	COG0784	Response regulator, receiver
L2Z21_09780	COG2205	protein histidine kinase activity
L2Z21_09780	COG5002	protein histidine kinase activity
L2Z21_09785	COG1024	Enoyl-CoA hydratase
L2Z21_09790	COG2084	Dehydrogenase
L2Z21_09795	COG3622	Belongs to the hyi family
L2Z21_09825	COG0697	spore germination
L2Z21_09835	COG2814	Major facilitator Superfamily
L2Z21_09840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z21_09850	COG0583	DNA-binding transcription factor activity
L2Z21_09860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z21_09870	COG0084	hydrolase, TatD family'
L2Z21_09885	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z21_09915	COG0440	acetolactate synthase activity
L2Z21_09920	COG0028	Belongs to the TPP enzyme family
L2Z21_09945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_09950	COG1136	(ABC) transporter
L2Z21_09950	COG0577	efflux transmembrane transporter activity
L2Z21_09955	COG1538	Outer membrane efflux protein
L2Z21_09970	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z21_09975	COG1162	GTPase activity
L2Z21_09985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z21_10025	COG1426	Protein conserved in bacteria
L2Z21_10060	COG0793	Belongs to the peptidase S41A family
L2Z21_10075	COG2267	carboxylic ester hydrolase activity
L2Z21_10085	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_10090	COG3265	gluconokinase activity
L2Z21_10100	COG0800	Aldolase
L2Z21_10110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z21_10115	COG0280	phosphate acetyltransferase
L2Z21_10115	COG0857	belongs to the CobB CobQ family
L2Z21_10120	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z21_10120	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z21_10140	COG0740	serine-type endopeptidase activity
L2Z21_10150	COG4774	siderophore transport
L2Z21_10160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z21_10170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z21_10170	COG2813	Specifically methylates the guanine in position
L2Z21_10270	COG0788	formyltetrahydrofolate deformylase activity
L2Z21_10295	COG4651	solute:proton antiporter activity
L2Z21_10295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z21_10315	COG0724	RNA recognition motif
L2Z21_10320	COG0210	DNA helicase
L2Z21_10345	COG1733	regulation of RNA biosynthetic process
L2Z21_10355	COG2900	Belongs to the SlyX family
L2Z21_10360	COG0488	(ABC) transporter
L2Z21_10365	COG1280	lysine exporter protein (LysE YggA)
L2Z21_10370	COG1560	Kdo2-lipid A biosynthetic process
L2Z21_10380	COG1301	dicarboxylic acid transport
L2Z21_10435	COG0473	3-isopropylmalate dehydrogenase activity
L2Z21_10490	COG0583	DNA-binding transcription factor activity
L2Z21_10500	COG0625	glutathione transferase activity
L2Z21_10505	COG2378	regulation of single-species biofilm formation
L2Z21_10510	COG0546	phosphoglycolate phosphatase activity
L2Z21_10525	COG1530	ribonuclease E activity
L2Z21_10530	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z21_10545	COG0583	DNA-binding transcription factor activity
L2Z21_10550	COG4221	oxidoreductase activity
L2Z21_10555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z21_10565	COG0534	Mate efflux family protein
L2Z21_10580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z21_10605	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z21_10605	COG0493	'glutamate synthase
L2Z21_10615	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z21_10620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z21_10635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z21_10645	COG0644	oxidoreductase
L2Z21_10645	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z21_10655	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z21_10660	COG4535	Mg2 and Co2 transporter CorC
L2Z21_10670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z21_10690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z21_10695	COG0475	glutathione-regulated potassium exporter activity
L2Z21_10695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z21_10710	COG0484	heat shock protein binding
L2Z21_10715	COG0789	Transcriptional regulator
L2Z21_10720	COG0598	Magnesium transport protein CorA
L2Z21_10735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z21_10740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z21_10745	COG1074	ATP-dependent DNA helicase activity
L2Z21_10750	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z21_10770	COG2226	methyltransferase
L2Z21_10785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_10790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z21_10805	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z21_10805	COG2111	Na H antiporter
L2Z21_10810	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z21_10815	COG0651	ATP synthesis coupled electron transport
L2Z21_10820	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z21_10825	COG2212	antiporter activity
L2Z21_10830	COG1320	monovalent cation:proton antiporter activity
L2Z21_10845	COG0195	Participates in both transcription termination and antitermination
L2Z21_10900	COG0237	dephospho-CoA kinase activity
L2Z21_10910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z21_10925	COG0497	DNA recombination
L2Z21_10935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z21_10965	COG2169	Transcriptional regulator
L2Z21_10965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z21_10970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z21_11030	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z21_11045	COG0326	Molecular chaperone. Has ATPase activity
L2Z21_11060	COG2056	Na+-H+ antiporter family
L2Z21_11160	COG0546	phosphoglycolate phosphatase activity
L2Z21_11165	COG1716	ATPase activity
L2Z21_11210	COG0181	hydroxymethylbilane synthase activity
L2Z21_11220	COG3275	phosphorelay sensor kinase activity
L2Z21_11240	COG1538	Outer membrane efflux protein
L2Z21_11245	COG0697	spore germination
L2Z21_11270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z21_11275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z21_11280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z21_11285	COG0772	Belongs to the SEDS family
L2Z21_11310	COG4974	Belongs to the 'phage' integrase family
L2Z21_11315	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z21_11325	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z21_11335	COG2197	response regulator
L2Z21_11350	COG0793	Belongs to the peptidase S41A family
L2Z21_11355	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z21_11360	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z21_11400	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z21_11400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z21_11430	COG0347	Belongs to the P(II) protein family
L2Z21_11515	COG0789	Transcriptional regulator
L2Z21_11540	COG0659	secondary active sulfate transmembrane transporter activity
L2Z21_11610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z21_11630	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z21_11645	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z21_11655	COG0477	Major facilitator Superfamily
L2Z21_11660	COG2860	membrane
L2Z21_11665	COG3012	SEC-C Motif Domain Protein
L2Z21_11670	COG1253	flavin adenine dinucleotide binding
L2Z21_11680	COG0477	Major facilitator Superfamily
L2Z21_11690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z21_11730	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z21_11740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z21_11810	COG0758	DNA mediated transformation
L2Z21_11820	COG0697	spore germination
L2Z21_11825	COG1309	transcriptional regulator
L2Z21_11840	COG0386	Belongs to the glutathione peroxidase family
L2Z21_11905	COG1121	(ABC) transporter
L2Z21_11910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z21_11915	COG1280	lysine exporter protein (LysE YggA)
L2Z21_11920	COG2837	iron assimilation
L2Z21_11925	COG0281	malic enzyme
L2Z21_11970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z21_11970	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z21_11975	COG4399	Belongs to the UPF0754 family
L2Z21_11980	COG2259	Doxx family
L2Z21_11985	COG0586	Pfam SNARE associated Golgi protein
L2Z21_12000	COG1192	Involved in chromosome partitioning
L2Z21_12010	COG0271	Belongs to the BolA IbaG family
L2Z21_12030	COG2267	carboxylic ester hydrolase activity
L2Z21_12050	COG3321	synthase
L2Z21_12050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z21_12050	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z21_12050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z21_12055	COG1960	acyl-CoA dehydrogenase activity
L2Z21_12065	COG2197	response regulator
L2Z21_12075	COG3916	Acyl-homoserine-lactone synthase
L2Z21_12080	COG0477	Major facilitator Superfamily
L2Z21_12085	COG1024	Enoyl-CoA hydratase
L2Z21_12090	COG1024	Enoyl-CoA hydratase
L2Z21_12095	COG1960	acyl-CoA dehydrogenase activity
L2Z21_12100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z21_12120	COG1113	amino acid transport
L2Z21_12125	COG1113	amino acid transport
L2Z21_12130	COG0251	oxidation-reduction process
L2Z21_12170	COG0564	pseudouridine synthase activity
L2Z21_12220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z21_12235	COG1802	Transcriptional regulator
L2Z21_12240	COG1448	Aminotransferase
L2Z21_12245	COG0277	FAD linked oxidase domain protein
L2Z21_12255	COG2186	Transcriptional regulator
L2Z21_12265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z21_12270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z21_12285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z21_12295	COG0110	maltose O-acetyltransferase activity
L2Z21_12300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z21_12330	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z21_12335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2Z21_12340	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z21_12380	COG0728	peptidoglycan biosynthetic process
L2Z21_12385	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z21_12440	COG0546	phosphoglycolate phosphatase activity
L2Z21_12445	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_12465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z21_12470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z21_12475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z21_12480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z21_12485	COG1116	anion transmembrane transporter activity
L2Z21_12490	COG1309	transcriptional regulator
L2Z21_12495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z21_12505	COG0196	riboflavin kinase activity
L2Z21_12510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z21_12520	COG1047	Peptidyl-prolyl cis-trans
L2Z21_12560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z21_12565	COG0657	acetylesterase activity
L2Z21_12585	COG0583	DNA-binding transcription factor activity
L2Z21_12615	COG2951	lytic endotransglycosylase activity
L2Z21_12620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z21_12635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z21_12645	COG0671	phosphoesterase, PA-phosphatase related
L2Z21_12650	COG0861	Integral membrane protein TerC family
L2Z21_12660	COG0754	glutathionylspermidine amidase activity
L2Z21_12670	COG0402	S-adenosylhomocysteine deaminase activity
L2Z21_12685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z21_12690	COG1230	cation diffusion facilitator family transporter
L2Z21_12705	COG0706	membrane insertase activity
L2Z21_12730	COG0592	DNA-directed DNA polymerase activity
L2Z21_12740	COG0187	DNA topoisomerase II activity
L2Z21_12750	COG0586	Pfam SNARE associated Golgi protein
L2Z21_12755	COG0488	(ABC) transporter
L2Z21_12780	COG0596	Alpha beta hydrolase
L2Z21_12785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z21_12790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z21_12830	COG0733	neurotransmitter:sodium symporter activity
L2Z21_12865	COG0583	DNA-binding transcription factor activity
L2Z21_12870	COG2233	PERMEase
L2Z21_12885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_12920	COG2814	Major facilitator Superfamily
L2Z21_12925	COG0656	L-ascorbic acid biosynthetic process
L2Z21_12930	COG0583	DNA-binding transcription factor activity
L2Z21_12945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z21_12950	COG1064	alcohol dehydrogenase
L2Z21_12955	COG2818	Glycosylase
L2Z21_12970	COG1194	a g-specific adenine glycosylase
L2Z21_12990	COG2983	Belongs to the UPF0260 family
L2Z21_12995	COG2133	pyrroloquinoline quinone binding
L2Z21_13000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z21_13005	COG2116	formate transmembrane transporter activity
L2Z21_13025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z21_13030	COG1335	isochorismatase
L2Z21_13035	COG0385	Bile acid
L2Z21_13040	COG0534	Mate efflux family protein
L2Z21_13045	COG1683	Conserved Protein
L2Z21_13065	COG0625	glutathione transferase activity
L2Z21_13075	COG1113	amino acid transport
L2Z21_13085	COG0523	cobalamin synthesis protein
L2Z21_13095	COG2188	Transcriptional regulator
L2Z21_13125	COG0010	Belongs to the arginase family
L2Z21_13140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z21_13150	COG2205	protein histidine kinase activity
L2Z21_13160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z21_13170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z21_13175	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z21_13260	COG0534	Mate efflux family protein
L2Z21_13265	COG0436	Aminotransferase
L2Z21_13270	COG2733	membrane
L2Z21_13285	COG2918	glutathione biosynthetic process
L2Z21_13340	COG3150	esterase
L2Z21_13350	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z21_13360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z21_13370	COG2233	PERMEase
L2Z21_13375	COG2351	hydroxyisourate hydrolase activity
L2Z21_13410	COG3706	GGDEF domain
L2Z21_13425	COG1393	Belongs to the ArsC family
L2Z21_13430	COG0708	Exodeoxyribonuclease III
L2Z21_13450	COG0189	ligase activity
L2Z21_13470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z21_13480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z21_13495	COG4942	peptidase
L2Z21_13505	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z21_13515	COG2119	membrane
L2Z21_13520	COG4774	siderophore transport
L2Z21_13525	COG0426	domain, Protein
L2Z21_13525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z21_13550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z21_13570	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_13575	COG1519	Transferase
L2Z21_13580	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z21_13585	COG0668	transmembrane transport
L2Z21_13595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z21_13600	COG1335	isochorismatase
L2Z21_13605	COG1522	sequence-specific DNA binding
L2Z21_13630	COG0784	Response regulator, receiver
L2Z21_13630	COG2198	Histidine kinase
L2Z21_13630	COG2205	protein histidine kinase activity
L2Z21_13635	COG3162	membrane
L2Z21_13640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z21_13650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_13665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z21_13670	COG1309	transcriptional regulator
L2Z21_13690	COG0351	phosphomethylpyrimidine kinase
L2Z21_13690	COG0352	thiamine-phosphate diphosphorylase activity
L2Z21_13690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z21_13700	COG2814	Major facilitator Superfamily
L2Z21_13715	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z21_13725	COG1113	amino acid transport
L2Z21_13735	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z21_13740	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_13750	COG1335	isochorismatase
L2Z21_13780	COG2814	Major facilitator Superfamily
L2Z21_13785	COG0583	DNA-binding transcription factor activity
L2Z21_13805	COG0667	Aldo Keto reductase
L2Z21_13825	COG1733	regulation of RNA biosynthetic process
L2Z21_13840	COG1733	regulation of RNA biosynthetic process
L2Z21_13845	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z21_13855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2Z21_13915	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z21_13955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z21_13985	COG0427	acetyl-CoA hydrolase
L2Z21_14010	COG0659	secondary active sulfate transmembrane transporter activity
L2Z21_14015	COG4221	oxidoreductase activity
L2Z21_14020	COG2873	o-acetylhomoserine
L2Z21_14025	COG0488	(ABC) transporter
L2Z21_14090	COG0833	amino acid
L2Z21_14135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z21_14140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z21_14155	COG2226	methyltransferase
L2Z21_14205	COG0070	glutamate synthase
L2Z21_14205	COG0067	glutamate synthase
L2Z21_14205	COG0069	glutamate synthase activity
L2Z21_14210	COG0493	'glutamate synthase
L2Z21_14220	COG1704	LemA family
L2Z21_14225	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z21_14240	COG3307	-O-antigen
L2Z21_14260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z21_14275	COG0194	GDP metabolic process
L2Z21_14325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z21_14345	COG5380	lipid catabolic process
L2Z21_14350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z21_14375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z21_14380	COG0277	FAD linked oxidase domain protein
L2Z21_14390	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z21_14395	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z21_14420	COG0628	permease
L2Z21_14425	COG1192	Involved in chromosome partitioning
L2Z21_14455	COG0833	amino acid
L2Z21_14460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z21_14465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z21_14475	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_14515	COG0583	DNA-binding transcription factor activity
L2Z21_14565	COG0517	IMP dehydrogenase activity
L2Z21_14570	COG1983	PspC domain protein
L2Z21_14580	COG1960	acyl-CoA dehydrogenase activity
L2Z21_14595	COG0408	coproporphyrinogen oxidase activity
L2Z21_14615	COG0513	Belongs to the DEAD box helicase family
L2Z21_14625	COG1127	ABC transporter
L2Z21_14630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z21_14640	COG2854	intermembrane phospholipid transfer
L2Z21_14650	COG0598	Magnesium transport protein CorA
L2Z21_14660	COG0494	nUDIX hydrolase
L2Z21_14665	COG1040	competence protein
L2Z21_14670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z21_14690	COG1946	Acyl-CoA thioesterase
L2Z21_14695	COG1301	dicarboxylic acid transport
L2Z21_14710	COG1959	2 iron, 2 sulfur cluster binding
L2Z21_14715	COG1017	nitric oxide dioxygenase activity
L2Z21_14715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z21_14720	COG0433	COG0433 Predicted ATPase
L2Z21_14725	COG0626	cystathionine gamma-synthase activity
L2Z21_14880	COG1960	acyl-CoA dehydrogenase activity
L2Z21_14885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z21_14915	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z21_14920	COG0339	signal peptide processing
L2Z21_14925	COG0557	exoribonuclease II activity
L2Z21_14970	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z21_14975	COG2169	Transcriptional regulator
L2Z21_14980	COG0697	spore germination
L2Z21_14985	COG1295	ribonuclease BN
L2Z21_15020	COG1702	phosphate starvation-inducible protein PhoH
L2Z21_15030	COG0741	lytic transglycosylase activity
L2Z21_15030	COG0739	heme binding
L2Z21_15030	COG1196	nuclear chromosome segregation
L2Z21_15060	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z21_15065	COG1183	phosphatidylcholine synthase activity
L2Z21_15110	COG1960	acyl-CoA dehydrogenase activity
L2Z21_15115	COG1309	transcriptional regulator
L2Z21_15130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z21_15135	COG1960	acyl-CoA dehydrogenase activity
L2Z21_15155	COG2969	positive regulation of protein catabolic process
L2Z21_15165	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z21_15180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z21_15185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z21_15205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z21_15215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z21_15220	COG1408	metallophosphoesterase
L2Z21_15230	COG2199	diguanylate cyclase activity
L2Z21_15290	COG1607	acyl-coa hydrolase
L2Z21_15320	COG2350	Protein conserved in bacteria
L2Z21_15330	COG0613	PHP domain protein
L2Z21_15335	COG3781	membrane
L2Z21_15345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z21_15360	COG1862	Preprotein translocase
L2Z21_15405	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z21_15410	COG0629	single-stranded DNA binding
L2Z21_15455	COG3646	Phage regulatory protein
L2Z21_15465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2Z21_15610	COG2205	protein histidine kinase activity
L2Z21_15615	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z21_15635	COG0726	polysaccharide deacetylase
L2Z21_15640	COG0463	Glycosyl transferase, family 2
L2Z21_15645	COG0438	transferase activity, transferring glycosyl groups
L2Z21_15710	COG1960	acyl-CoA dehydrogenase activity
L2Z21_15715	COG1960	acyl-CoA dehydrogenase activity
L2Z21_15725	COG2205	protein histidine kinase activity
L2Z21_15730	COG0745	RESPONSE REGULATOR receiver
L2Z21_15735	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z21_15755	COG2096	Adenosyltransferase
L2Z21_15805	COG0285	dihydrofolate synthase activity
L2Z21_15825	COG0450	alkyl hydroperoxide reductase
L2Z21_15840	COG0477	Major facilitator Superfamily
L2Z21_15845	COG1272	protein, Hemolysin III
L2Z21_15855	COG2153	protein acetylation
L2Z21_15875	COG0183	Belongs to the thiolase family
L2Z21_15880	COG2207	Transcriptional regulator
L2Z21_15900	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_15920	COG0183	Belongs to the thiolase family
L2Z21_15930	COG2885	chlorophyll binding
L2Z21_15930	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z21_15940	COG1690	Belongs to the RtcB family
L2Z21_15945	COG0833	amino acid
L2Z21_15955	COG2233	PERMEase
L2Z21_15960	COG1217	gtp-binding protein TYPA
L2Z21_15985	COG2094	Belongs to the DNA glycosylase MPG family
L2Z21_15990	COG4772	TonB-dependent receptor
L2Z21_15995	COG1902	pentaerythritol trinitrate reductase activity
L2Z21_16010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z21_16015	COG0354	folic acid binding
L2Z21_16025	COG3189	MarR family transcriptional regulator
L2Z21_16030	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z21_16035	COG3422	double-strand break repair
L2Z21_16075	COG0840	transmembrane signaling receptor activity
L2Z21_16105	COG5510	response to toxic substance
L2Z21_16115	COG2832	Protein of unknown function (DUF454)
L2Z21_16120	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z21_16160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z21_16170	COG1289	transmembrane transporter activity
L2Z21_16175	COG2814	Major facilitator Superfamily
L2Z21_16195	COG1115	amino acid carrier protein
L2Z21_16200	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z21_16205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z21_16210	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z21_16235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z21_16245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z21_16250	COG1077	Cell shape determining protein MreB Mrl
L2Z21_16255	COG1792	Involved in formation and maintenance of cell shape
L2Z21_16260	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z21_16265	COG0424	maF-like protein
L2Z21_16270	COG1530	ribonuclease E activity
L2Z21_16280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z21_16290	COG0560	Phosphoserine phosphatase
L2Z21_16300	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z21_16325	COG2207	Transcriptional regulator
L2Z21_16345	COG1113	amino acid transport
L2Z21_16350	COG2828	Protein conserved in bacteria
L2Z21_16355	COG0142	geranyltranstransferase activity
L2Z21_16360	COG2315	Protein conserved in bacteria
L2Z21_16375	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z21_16410	COG4372	Transposase
L2Z21_16420	COG0745	RESPONSE REGULATOR receiver
L2Z21_16425	COG0642	Histidine kinase
L2Z21_16435	COG0004	ammonium transporteR
L2Z21_16440	COG0583	DNA-binding transcription factor activity
L2Z21_16460	COG0525	valine-tRNA ligase activity
L2Z21_16470	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z21_16480	COG0393	Putative heavy-metal-binding
L2Z21_16485	COG0393	Putative heavy-metal-binding
L2Z21_16490	COG1538	Outer membrane efflux protein
L2Z21_16500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_16505	COG0671	phosphoesterase, PA-phosphatase related
L2Z21_16535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z21_16550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z21_16550	COG1648	precorrin-2 dehydrogenase activity
L2Z21_16555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z21_16560	COG1733	regulation of RNA biosynthetic process
L2Z21_16570	COG0531	amino acid
L2Z21_16585	COG0321	lipoyl(octanoyl) transferase activity
L2Z21_16590	COG2921	Belongs to the UPF0250 family
L2Z21_16630	COG2009	succinate dehydrogenase
L2Z21_16635	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z21_16640	COG1053	succinate dehydrogenase
L2Z21_16645	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z21_16670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z21_16690	COG2354	Protein conserved in bacteria
L2Z21_16695	COG2321	neutral zinc metallopeptidase
L2Z21_16715	COG2843	Capsule synthesis protein
L2Z21_16730	COG0589	response to stress
L2Z21_16750	COG0505	Belongs to the CarA family
L2Z21_16775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z21_16780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z21_16830	COG0477	Major facilitator Superfamily
L2Z21_16835	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z21_16850	COG1597	lipid kinase activity
L2Z21_16855	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z21_16880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z21_16885	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z21_16905	COG0741	lytic transglycosylase activity
L2Z21_16925	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z21_16940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z21_16975	COG0778	Nitroreductase
L2Z21_16990	COG1929	Belongs to the glycerate kinase type-1 family
L2Z21_16995	COG0243	molybdopterin cofactor binding
L2Z21_17000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z21_17005	COG3339	Conserved Protein
L2Z21_17015	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z21_17035	COG1113	amino acid transport
L2Z21_17045	COG0019	diaminopimelate decarboxylase activity
L2Z21_17055	COG2267	carboxylic ester hydrolase activity
L2Z21_17060	COG1280	lysine exporter protein (LysE YggA)
L2Z21_17065	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z21_17115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z21_17150	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z21_17155	COG1136	(ABC) transporter
L2Z21_17160	COG0658	competence protein
L2Z21_17160	COG2333	competence protein COMEC
L2Z21_17170	COG0616	signal peptide processing
L2Z21_17170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z21_17175	COG0596	Alpha beta hydrolase
L2Z21_17180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z21_17190	COG0628	permease
L2Z21_17225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z21_17245	COG0823	Involved in the tonB-independent uptake of proteins
L2Z21_17265	COG0824	Thioesterase
L2Z21_17270	COG1473	amidohydrolase
L2Z21_17290	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z21_17290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z21_17295	COG2814	Major facilitator Superfamily
L2Z21_17305	COG1024	Enoyl-CoA hydratase
L2Z21_17310	COG1051	belongs to the nudix hydrolase family
L2Z21_17310	COG1056	cytidyltransferase-related domain
L2Z21_17320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z21_17335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z21_17350	COG4625	pathogenesis
L2Z21_17355	COG0583	DNA-binding transcription factor activity
L2Z21_17360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z21_17365	COG4208	sulfate ABC transporter
L2Z21_17370	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z21_17380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z21_17385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z21_17390	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z21_17410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z21_17425	COG0681	Belongs to the peptidase S26 family
L2Z21_17440	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z21_17450	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z21_17455	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z21_17465	COG4221	oxidoreductase activity
L2Z21_17495	COG0436	Aminotransferase
L2Z21_17515	COG0556	nucleotide-excision repair
L2Z21_17570	COG2070	2-Nitropropane dioxygenase
L2Z21_17600	COG1215	transferase activity, transferring glycosyl groups
L2Z21_17615	COG0415	Belongs to the DNA photolyase family
L2Z21_17625	COG1252	NADH dehydrogenase
L2Z21_17655	COG1187	pseudouridine synthase activity
L2Z21_17675	COG0477	Major facilitator Superfamily
L2Z21_17680	COG0583	DNA-binding transcription factor activity
L2Z21_17685	COG1823	symporter activity
L2Z21_17695	COG0612	Peptidase, M16
L2Z21_17720	COG0352	thiamine-phosphate diphosphorylase activity
L2Z21_17755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z21_17770	COG1309	transcriptional regulator
L2Z21_17780	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z21_17785	COG0076	glutamate decarboxylase activity
L2Z21_17795	COG1522	sequence-specific DNA binding
L2Z21_17800	COG3961	Belongs to the TPP enzyme family
L2Z21_17805	COG1113	amino acid transport
L2Z21_17810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z21_17815	COG0573	inorganic phosphate transmembrane transporter activity
L2Z21_17825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z21_17830	COG0616	signal peptide processing
L2Z21_17865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z21_17870	COG1686	Belongs to the peptidase S11 family
L2Z21_17895	COG0583	DNA-binding transcription factor activity
L2Z21_17900	COG1067	ATP-dependent peptidase activity
L2Z21_17945	COG1966	Carbon starvation protein
L2Z21_17950	COG2879	small protein
L2Z21_17985	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z21_17985	COG2508	Transcriptional regulator
L2Z21_18015	COG4372	Transposase
L2Z21_18025	COG1113	amino acid transport
L2Z21_18030	COG0583	DNA-binding transcription factor activity
L2Z21_18035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_18040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z21_18050	COG1012	belongs to the aldehyde dehydrogenase family
L2Z21_18060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z21_18065	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z21_18065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z21_18100	COG2814	Major facilitator Superfamily
L2Z21_18105	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z21_18115	COG1309	transcriptional regulator
L2Z21_18135	COG1741	Belongs to the pirin family
L2Z21_18145	COG2964	Protein conserved in bacteria
L2Z21_18160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z21_18165	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z21_18170	COG4605	iron ion homeostasis
L2Z21_18175	COG4604	ABC transporter, ATP-binding protein
L2Z21_18180	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z21_18185	COG4774	siderophore transport
L2Z21_18195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z21_18200	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z21_18205	COG3433	isochorismatase activity
L2Z21_18205	COG1535	isochorismatase
L2Z21_18220	COG1132	(ABC) transporter
L2Z21_18225	COG1132	(ABC) transporter
L2Z21_18230	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z21_18240	COG1169	isochorismate synthase
L2Z21_18255	COG3739	integral membrane protein
L2Z21_18315	COG3293	Transposase