locus-tag	class	description
L2Z22_00010	COG0534	Mate efflux family protein
L2Z22_00020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z22_00025	COG4221	oxidoreductase activity
L2Z22_00030	COG0583	DNA-binding transcription factor activity
L2Z22_00045	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z22_00050	COG1530	ribonuclease E activity
L2Z22_00060	COG0546	phosphoglycolate phosphatase activity
L2Z22_00065	COG2378	regulation of single-species biofilm formation
L2Z22_00070	COG0625	glutathione transferase activity
L2Z22_00080	COG0583	DNA-binding transcription factor activity
L2Z22_00145	COG0473	3-isopropylmalate dehydrogenase activity
L2Z22_00200	COG1301	dicarboxylic acid transport
L2Z22_00210	COG1560	Kdo2-lipid A biosynthetic process
L2Z22_00215	COG1280	lysine exporter protein (LysE YggA)
L2Z22_00220	COG0488	(ABC) transporter
L2Z22_00225	COG2900	Belongs to the SlyX family
L2Z22_00235	COG1733	regulation of RNA biosynthetic process
L2Z22_00260	COG0210	DNA helicase
L2Z22_00265	COG0724	RNA recognition motif
L2Z22_00285	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z22_00285	COG4651	solute:proton antiporter activity
L2Z22_00310	COG0788	formyltetrahydrofolate deformylase activity
L2Z22_00410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z22_00410	COG2813	Specifically methylates the guanine in position
L2Z22_00420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z22_00435	COG4774	siderophore transport
L2Z22_00445	COG0740	serine-type endopeptidase activity
L2Z22_00465	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z22_00465	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z22_00470	COG0280	phosphate acetyltransferase
L2Z22_00470	COG0857	belongs to the CobB CobQ family
L2Z22_00475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z22_00485	COG0800	Aldolase
L2Z22_00495	COG3265	gluconokinase activity
L2Z22_00500	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_00510	COG2267	carboxylic ester hydrolase activity
L2Z22_00525	COG0793	Belongs to the peptidase S41A family
L2Z22_00560	COG1426	Protein conserved in bacteria
L2Z22_00605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z22_00615	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z22_00630	COG2986	histidine ammonia-lyase
L2Z22_00670	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_00675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z22_00695	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z22_00705	COG1162	GTPase activity
L2Z22_00710	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z22_00725	COG1538	Outer membrane efflux protein
L2Z22_00730	COG1136	(ABC) transporter
L2Z22_00730	COG0577	efflux transmembrane transporter activity
L2Z22_00735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z22_00760	COG0028	Belongs to the TPP enzyme family
L2Z22_00765	COG0440	acetolactate synthase activity
L2Z22_00795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z22_00810	COG0084	hydrolase, TatD family'
L2Z22_00825	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z22_00835	COG0583	DNA-binding transcription factor activity
L2Z22_00845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z22_00850	COG2814	Major facilitator Superfamily
L2Z22_00900	COG3622	Belongs to the hyi family
L2Z22_00905	COG2084	Dehydrogenase
L2Z22_00910	COG1024	Enoyl-CoA hydratase
L2Z22_00915	COG5002	protein histidine kinase activity
L2Z22_00915	COG0784	Response regulator, receiver
L2Z22_00915	COG2205	protein histidine kinase activity
L2Z22_00935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z22_00945	COG3956	TIGRFAM MazG family protein
L2Z22_00950	COG1555	photosystem II stabilization
L2Z22_00955	COG0617	tRNA 3'-terminal CCA addition
L2Z22_00960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z22_00980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z22_00985	COG3028	Belongs to the UPF0307 family
L2Z22_00990	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z22_01005	COG0625	glutathione transferase activity
L2Z22_01010	COG1238	metal cluster binding
L2Z22_01055	COG0072	phenylalanine-tRNA ligase activity
L2Z22_01085	COG0248	Ppx GppA phosphatase
L2Z22_01095	COG0037	tRNA processing
L2Z22_01135	COG1764	response to oxidative stress
L2Z22_01140	COG1846	Transcriptional regulator
L2Z22_01150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z22_01210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z22_01215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z22_01220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z22_01255	COG4372	Transposase
L2Z22_01300	COG1214	PFAM Peptidase M22, glycoprotease
L2Z22_01325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z22_01330	COG0561	phosphatase activity
L2Z22_01340	COG2132	Multicopper oxidase
L2Z22_01345	COG3667	copper resistance
L2Z22_01360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z22_01365	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z22_01370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z22_01400	COG1063	alcohol dehydrogenase
L2Z22_01405	COG0583	DNA-binding transcription factor activity
L2Z22_01410	COG1960	acyl-CoA dehydrogenase activity
L2Z22_01415	COG2814	Major facilitator Superfamily
L2Z22_01420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z22_01430	COG1053	succinate dehydrogenase
L2Z22_01435	COG0583	DNA-binding transcription factor activity
L2Z22_01450	COG0583	DNA-binding transcription factor activity
L2Z22_01480	COG0583	DNA-binding transcription factor activity
L2Z22_01495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z22_01530	COG4993	Dehydrogenase
L2Z22_01615	COG2205	protein histidine kinase activity
L2Z22_01625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z22_01645	COG0745	RESPONSE REGULATOR receiver
L2Z22_01685	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z22_01715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z22_01720	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z22_01740	COG0583	DNA-binding transcription factor activity
L2Z22_01760	COG0668	transmembrane transport
L2Z22_01770	COG2081	HI0933 family
L2Z22_01775	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z22_01805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z22_01805	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z22_01815	COG0489	protein tyrosine kinase activity
L2Z22_01865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z22_01875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z22_01890	COG0730	response to heat
L2Z22_01900	COG1196	nuclear chromosome segregation
L2Z22_01925	COG2223	nitrite transmembrane transporter activity
L2Z22_01930	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z22_01935	COG1877	trehalose-phosphatase activity
L2Z22_01945	COG2226	methyltransferase
L2Z22_01945	COG0596	Alpha beta hydrolase
L2Z22_01945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z22_01960	COG4106	trans-aconitate 2-methyltransferase activity
L2Z22_01975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z22_01980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z22_01985	COG0009	L-threonylcarbamoyladenylate synthase
L2Z22_01990	COG3101	peptidyl-lysine hydroxylation
L2Z22_01995	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z22_02020	COG1652	LysM domain
L2Z22_02025	COG0352	thiamine-phosphate diphosphorylase activity
L2Z22_02025	COG0351	phosphomethylpyrimidine kinase
L2Z22_02025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z22_02035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z22_02065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z22_02095	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z22_02110	COG0358	DNA primase activity
L2Z22_02120	COG0564	pseudouridine synthase activity
L2Z22_02145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z22_02165	COG0583	DNA-binding transcription factor activity
L2Z22_02170	COG0473	3-isopropylmalate dehydrogenase activity
L2Z22_02180	COG0657	acetylesterase activity
L2Z22_02190	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_02210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z22_02210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z22_02225	COG1981	membrane
L2Z22_02270	COG0456	acetyltransferase
L2Z22_02280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z22_02285	COG0492	ferredoxin-NADP+ reductase activity
L2Z22_02290	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z22_02290	COG1674	ftsk spoiiie
L2Z22_02295	COG1280	lysine exporter protein (LysE YggA)
L2Z22_02340	COG2894	cell division
L2Z22_02355	COG0204	Acyl-transferase
L2Z22_02360	COG2885	chlorophyll binding
L2Z22_02365	COG0210	DNA helicase
L2Z22_02375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z22_02390	COG0121	glutamine amidotransferase
L2Z22_02410	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z22_02415	COG0735	belongs to the Fur family
L2Z22_02440	COG0420	3'-5' exonuclease activity
L2Z22_02460	COG1090	epimerase
L2Z22_02475	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z22_02485	COG2814	Major facilitator Superfamily
L2Z22_02490	COG0405	Gamma-glutamyltransferase
L2Z22_02535	COG0477	Major facilitator Superfamily
L2Z22_02540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z22_02550	COG1595	DNA-templated transcription, initiation
L2Z22_02610	COG0531	amino acid
L2Z22_02615	COG2040	homocysteine
L2Z22_02645	COG1309	transcriptional regulator
L2Z22_02650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z22_02655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z22_02665	COG1607	acyl-coa hydrolase
L2Z22_02675	COG0523	cobalamin synthesis protein
L2Z22_02685	COG4681	YaeQ
L2Z22_02695	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z22_02695	COG0726	polysaccharide deacetylase
L2Z22_02700	COG1215	transferase activity, transferring glycosyl groups
L2Z22_02710	COG1024	Enoyl-CoA hydratase
L2Z22_02725	COG1414	Transcriptional regulator
L2Z22_02745	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_02755	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z22_02760	COG2271	Major facilitator Superfamily
L2Z22_02770	COG2267	carboxylic ester hydrolase activity
L2Z22_02775	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_02790	COG0028	Belongs to the TPP enzyme family
L2Z22_02800	COG0477	Major facilitator Superfamily
L2Z22_02805	COG0242	peptide deformylase activity
L2Z22_02810	COG2066	Belongs to the glutaminase family
L2Z22_02815	COG2207	Transcriptional regulator
L2Z22_02820	COG2223	nitrite transmembrane transporter activity
L2Z22_02835	COG0583	DNA-binding transcription factor activity
L2Z22_02840	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_02845	COG2271	Major facilitator Superfamily
L2Z22_02850	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z22_02855	COG3958	Transketolase
L2Z22_02865	COG0306	phosphate transporter
L2Z22_02885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z22_02930	COG4181	ATPase activity
L2Z22_02935	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z22_02965	COG0583	DNA-binding transcription factor activity
L2Z22_02975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z22_02980	COG1773	rubredoxin
L2Z22_03030	COG2851	Citrate transporter
L2Z22_03035	COG1253	flavin adenine dinucleotide binding
L2Z22_03080	COG0804	urea catabolic process
L2Z22_03090	COG0830	nickel cation binding
L2Z22_03105	COG0742	ribosomal rna small subunit methyltransferase
L2Z22_03110	COG0768	penicillin binding
L2Z22_03135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z22_03140	COG2878	Part of a membrane complex involved in electron transport
L2Z22_03145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z22_03155	COG3384	dioxygenase
L2Z22_03180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z22_03365	COG5410	chromosome segregation
L2Z22_03580	COG0582	viral genome integration into host DNA
L2Z22_03595	COG0174	glutamine synthetase
L2Z22_03605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z22_03635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z22_03640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z22_03645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z22_03665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z22_03670	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z22_03675	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z22_03690	COG1960	acyl-CoA dehydrogenase activity
L2Z22_03695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z22_03700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z22_03710	COG2223	nitrite transmembrane transporter activity
L2Z22_03720	COG0024	Methionine aminopeptidase
L2Z22_03725	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z22_03740	COG2207	Transcriptional regulator
L2Z22_03765	COG2951	lytic endotransglycosylase activity
L2Z22_03770	COG0772	Belongs to the SEDS family
L2Z22_03785	COG0842	Transport permease protein
L2Z22_03790	COG1131	(ABC) transporter
L2Z22_03835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z22_03850	COG4215	(ABC) transporter
L2Z22_03855	COG4160	amino acid transport
L2Z22_03860	COG4598	ABC transporter
L2Z22_03870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z22_03875	COG0826	peptidase U32
L2Z22_03880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z22_03895	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z22_03905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z22_03920	COG0642	Histidine kinase
L2Z22_03930	COG0494	nUDIX hydrolase
L2Z22_03940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z22_03945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z22_03950	COG3139	Protein of unknown function (DUF1315)
L2Z22_03955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z22_03965	COG1960	acyl-CoA dehydrogenase activity
L2Z22_03970	COG2819	hydrolase of the alpha beta superfamily
L2Z22_03980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z22_03990	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z22_03995	COG1234	tRNA 3'-trailer cleavage
L2Z22_04025	COG2363	Small membrane protein
L2Z22_04050	COG0513	Belongs to the DEAD box helicase family
L2Z22_04060	COG0778	Nitroreductase
L2Z22_04090	COG1286	toxin biosynthetic process
L2Z22_04115	COG4783	chaperone-mediated protein folding
L2Z22_04120	COG1610	YqeY-like protein
L2Z22_04235	COG0300	oxidoreductase activity
L2Z22_04265	COG1309	transcriptional regulator
L2Z22_04270	COG1741	Belongs to the pirin family
L2Z22_04285	COG2072	flavoprotein involved in K transport
L2Z22_04295	COG2252	PERMEase
L2Z22_04300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z22_04305	COG3038	cytochrome b561
L2Z22_04315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z22_04325	COG0527	aspartate kinase activity
L2Z22_04335	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z22_04350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z22_04365	COG0667	Aldo Keto reductase
L2Z22_04380	COG1765	OsmC-like protein
L2Z22_04395	COG0542	response to heat
L2Z22_04430	COG2885	chlorophyll binding
L2Z22_04440	COG0625	glutathione transferase activity
L2Z22_04445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z22_04465	COG3634	alkyl hydroperoxide reductase activity
L2Z22_04475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z22_04485	COG0450	alkyl hydroperoxide reductase
L2Z22_04495	COG1643	Atp-dependent helicase
L2Z22_04510	COG2814	Major facilitator Superfamily
L2Z22_04515	COG3135	benzoate transporter
L2Z22_04520	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_04525	COG0633	Ferredoxin
L2Z22_04525	COG0543	2 iron, 2 sulfur cluster binding
L2Z22_04530	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z22_04535	COG4638	Rieske (2fe-2S)
L2Z22_04545	COG0583	DNA-binding transcription factor activity
L2Z22_04615	COG2814	Major facilitator Superfamily
L2Z22_04630	COG2826	transposase and inactivated derivatives, IS30 family
L2Z22_04655	COG0517	IMP dehydrogenase activity
L2Z22_04655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z22_04660	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z22_04670	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z22_04675	COG1137	ATPase activity
L2Z22_04680	COG1538	Outer membrane efflux protein
L2Z22_04710	COG4122	O-methyltransferase activity
L2Z22_04720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z22_04735	COG1522	sequence-specific DNA binding
L2Z22_04740	COG5006	permease, DMT superfamily
L2Z22_04750	COG1560	Kdo2-lipid A biosynthetic process
L2Z22_04765	COG2814	Major facilitator Superfamily
L2Z22_04785	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z22_04835	COG0583	DNA-binding transcription factor activity
L2Z22_04840	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z22_04860	COG4770	biotin carboxylase activity
L2Z22_04865	COG0038	chloride channel
L2Z22_04885	COG1309	transcriptional regulator
L2Z22_04895	COG1063	alcohol dehydrogenase
L2Z22_04920	COG0439	Biotin carboxylase
L2Z22_04925	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z22_04945	COG0864	Transcriptional regulator
L2Z22_04955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z22_04960	COG1116	anion transmembrane transporter activity
L2Z22_05085	COG0590	tRNA wobble adenosine to inosine editing
L2Z22_05090	COG2807	transmembrane transport
L2Z22_05105	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z22_05115	COG0789	Transcriptional regulator
L2Z22_05125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z22_05145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z22_05155	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z22_05170	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_05175	COG0531	amino acid
L2Z22_05180	COG1760	l-serine dehydratase
L2Z22_05185	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_05185	COG2030	dehydratase
L2Z22_05190	COG3396	Phenylacetate-CoA oxygenase
L2Z22_05195	COG3460	Phenylacetate-CoA oxygenase
L2Z22_05200	COG3396	Phenylacetate-CoA oxygenase
L2Z22_05205	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z22_05210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z22_05215	COG1024	Enoyl-CoA hydratase
L2Z22_05220	COG1024	Enoyl-CoA hydratase
L2Z22_05225	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z22_05230	COG0183	Belongs to the thiolase family
L2Z22_05235	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z22_05240	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z22_05250	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z22_05260	COG0556	nucleotide-excision repair
L2Z22_05295	COG1278	Cold shock
L2Z22_05305	COG2207	Transcriptional regulator
L2Z22_05375	COG1414	Transcriptional regulator
L2Z22_05380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z22_05395	COG3842	ATPase activity
L2Z22_05410	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z22_05415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z22_05420	COG2814	Major facilitator Superfamily
L2Z22_05425	COG1960	acyl-CoA dehydrogenase activity
L2Z22_05440	COG1024	Enoyl-CoA hydratase
L2Z22_05450	COG2814	Major facilitator Superfamily
L2Z22_05460	COG0183	Belongs to the thiolase family
L2Z22_05465	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z22_05470	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_05475	COG1024	Enoyl-CoA hydratase
L2Z22_05480	COG1960	acyl-CoA dehydrogenase activity
L2Z22_05485	COG2814	Major facilitator Superfamily
L2Z22_05490	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z22_05495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z22_05505	COG2814	Major facilitator Superfamily
L2Z22_05515	COG1960	acyl-CoA dehydrogenase activity
L2Z22_05530	COG0583	DNA-binding transcription factor activity
L2Z22_05540	COG4770	biotin carboxylase activity
L2Z22_05545	COG1024	Enoyl-CoA hydratase
L2Z22_05550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z22_05555	COG1960	acyl-CoA dehydrogenase activity
L2Z22_05560	COG1309	transcriptional regulator
L2Z22_05565	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z22_05585	COG0583	DNA-binding transcription factor activity
L2Z22_05635	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_05655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z22_05675	COG0784	Response regulator, receiver
L2Z22_05675	COG2205	protein histidine kinase activity
L2Z22_05695	COG0765	amino acid transport
L2Z22_05700	COG0765	amino acid transport
L2Z22_05705	COG1126	abc transporter atp-binding protein
L2Z22_05710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z22_05715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z22_05730	COG1280	lysine exporter protein (LysE YggA)
L2Z22_05740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z22_05745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z22_05760	COG2826	transposase and inactivated derivatives, IS30 family
L2Z22_05780	COG5410	chromosome segregation
L2Z22_05820	COG4372	Transposase
L2Z22_05895	COG1598	PFAM Uncharacterised protein family UPF0150
L2Z22_05920	COG2814	Major facilitator Superfamily
L2Z22_05935	COG0511	ligase activity, forming carbon-carbon bonds
L2Z22_05955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z22_05955	COG1116	anion transmembrane transporter activity
L2Z22_05960	COG0745	RESPONSE REGULATOR receiver
L2Z22_05970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z22_05970	COG2146	nitrite reductase [NAD(P)H] activity
L2Z22_05975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z22_05980	COG0243	molybdopterin cofactor binding
L2Z22_05990	COG0243	molybdopterin cofactor binding
L2Z22_05995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z22_06010	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z22_06010	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z22_06015	COG0303	'Molybdopterin
L2Z22_06025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z22_06030	COG0697	spore germination
L2Z22_06050	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z22_06055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z22_06110	COG2204	response regulator
L2Z22_06115	COG3852	Histidine kinase
L2Z22_06135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z22_06140	COG0575	Belongs to the CDS family
L2Z22_06175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z22_06190	COG2137	regulation of response to DNA damage stimulus
L2Z22_06200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z22_06205	COG1011	Hydrolase
L2Z22_06230	COG1522	sequence-specific DNA binding
L2Z22_06240	COG1113	amino acid transport
L2Z22_06260	COG0659	secondary active sulfate transmembrane transporter activity
L2Z22_06265	COG2135	peptidase activity
L2Z22_06285	COG4372	Transposase
L2Z22_06300	COG5001	Diguanylate cyclase
L2Z22_06300	COG3300	MHYT domain
L2Z22_06320	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z22_06320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z22_06320	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z22_06325	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z22_06330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z22_06330	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z22_06360	COG0024	Methionine aminopeptidase
L2Z22_06365	COG0583	DNA-binding transcription factor activity
L2Z22_06375	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z22_06380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z22_06385	COG0516	GMP reductase activity
L2Z22_06385	COG0517	IMP dehydrogenase activity
L2Z22_06415	COG0552	protein localization to endoplasmic reticulum
L2Z22_06425	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z22_06440	COG4890	Cyd operon protein YbgT
L2Z22_06445	COG1294	oxidase, subunit
L2Z22_06470	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z22_06480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z22_06485	COG4774	siderophore transport
L2Z22_06500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z22_06505	COG0569	domain protein
L2Z22_06510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z22_06540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z22_06545	COG0542	response to heat
L2Z22_06570	COG1902	pentaerythritol trinitrate reductase activity
L2Z22_06570	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z22_06615	COG2323	membrane
L2Z22_06620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z22_06630	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z22_06635	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z22_06640	COG0183	Belongs to the thiolase family
L2Z22_06645	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z22_06650	COG0596	Alpha beta hydrolase
L2Z22_06655	COG2271	Major facilitator Superfamily
L2Z22_06660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z22_06665	COG3485	protocatechuate 3,4-dioxygenase
L2Z22_06670	COG3485	protocatechuate 3,4-dioxygenase
L2Z22_06675	COG0710	3-dehydroquinate dehydratase activity
L2Z22_06680	COG3420	alginic acid biosynthetic process
L2Z22_06685	COG3659	wide pore channel activity
L2Z22_06690	COG4993	Dehydrogenase
L2Z22_06700	COG2391	methyltransferase activity
L2Z22_06715	COG1414	Transcriptional regulator
L2Z22_06720	COG0583	DNA-binding transcription factor activity
L2Z22_06725	COG1960	acyl-CoA dehydrogenase activity
L2Z22_06750	COG2814	Major facilitator Superfamily
L2Z22_06760	COG0154	amidase activity
L2Z22_06780	COG4638	Rieske (2fe-2S)
L2Z22_06790	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_06800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z22_06810	COG3733	amine oxidase
L2Z22_06820	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_06830	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z22_06835	COG0183	Belongs to the thiolase family
L2Z22_06840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z22_06845	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z22_06855	COG4829	muconolactone delta-isomerase
L2Z22_06860	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z22_06865	COG0583	DNA-binding transcription factor activity
L2Z22_06875	COG2186	Transcriptional regulator
L2Z22_06895	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_06915	COG1960	acyl-CoA dehydrogenase activity
L2Z22_06920	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_06960	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_06975	COG0753	catalase activity
L2Z22_06995	COG1846	Transcriptional regulator
L2Z22_07000	COG1902	pentaerythritol trinitrate reductase activity
L2Z22_07000	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z22_07010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z22_07040	COG1309	transcriptional regulator
L2Z22_07055	COG1335	isochorismatase
L2Z22_07060	COG0583	DNA-binding transcription factor activity
L2Z22_07070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z22_07070	COG0475	glutathione-regulated potassium exporter activity
L2Z22_07085	COG1473	amidohydrolase
L2Z22_07095	COG2831	hemolysin activation secretion protein
L2Z22_07100	COG3210	domain, Protein
L2Z22_07130	COG2188	Transcriptional regulator
L2Z22_07155	COG0583	DNA-binding transcription factor activity
L2Z22_07185	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z22_07220	COG1566	PFAM secretion protein HlyD family protein
L2Z22_07235	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_07240	COG0129	dihydroxy-acid dehydratase activity
L2Z22_07250	COG0583	DNA-binding transcription factor activity
L2Z22_07255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z22_07265	COG2084	Dehydrogenase
L2Z22_07270	COG2207	Transcriptional regulator
L2Z22_07285	COG1064	alcohol dehydrogenase
L2Z22_07295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z22_07300	COG1120	ATPase activity
L2Z22_07320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z22_07440	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z22_07490	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_07505	COG2207	Transcriptional regulator
L2Z22_07515	COG2205	protein histidine kinase activity
L2Z22_07520	COG0745	RESPONSE REGULATOR receiver
L2Z22_07525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z22_07530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z22_07535	COG1538	Outer membrane efflux protein
L2Z22_07545	COG2072	flavoprotein involved in K transport
L2Z22_07570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z22_07595	COG3539	Fimbrial protein
L2Z22_07620	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z22_07635	COG0753	catalase activity
L2Z22_07655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z22_07730	COG1535	isochorismatase
L2Z22_07730	COG3433	isochorismatase activity
L2Z22_07735	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_07740	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z22_07745	COG4149	molybdate abc transporter
L2Z22_07750	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z22_07760	COG4638	Rieske (2fe-2S)
L2Z22_07765	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z22_07770	COG0543	2 iron, 2 sulfur cluster binding
L2Z22_07770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z22_07795	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_07810	COG2207	Transcriptional regulator
L2Z22_07815	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_07820	COG2610	gluconate transmembrane transporter activity
L2Z22_07835	COG0583	DNA-binding transcription factor activity
L2Z22_07845	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z22_07850	COG2031	fatty acid transporter
L2Z22_07855	COG0183	Belongs to the thiolase family
L2Z22_07860	COG0583	DNA-binding transcription factor activity
L2Z22_07865	COG0583	DNA-binding transcription factor activity
L2Z22_07880	COG1027	Aspartate ammonia-lyase
L2Z22_07890	COG0477	Major facilitator Superfamily
L2Z22_07910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z22_07915	COG4521	taurine ABC transporter
L2Z22_07930	COG2188	Transcriptional regulator
L2Z22_07940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z22_07945	COG1733	regulation of RNA biosynthetic process
L2Z22_07950	COG3708	Transcriptional regulator
L2Z22_07950	COG2207	Transcriptional regulator
L2Z22_07965	COG0730	response to heat
L2Z22_07980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z22_07980	COG3453	Protein conserved in bacteria
L2Z22_07990	COG3781	membrane
L2Z22_07995	COG1063	alcohol dehydrogenase
L2Z22_08005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z22_08010	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z22_08015	COG0022	dehydrogenase e1 component
L2Z22_08020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z22_08025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z22_08055	COG0133	tryptophan synthase activity
L2Z22_08065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z22_08110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z22_08135	COG2226	methyltransferase
L2Z22_08185	COG0842	Transport permease protein
L2Z22_08190	COG0842	Transport permease protein
L2Z22_08195	COG1131	(ABC) transporter
L2Z22_08220	COG4372	Transposase
L2Z22_08230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z22_08235	COG4773	Receptor
L2Z22_08255	COG0730	response to heat
L2Z22_08260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z22_08280	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z22_08295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z22_08335	COG4264	IucA IucC family
L2Z22_08340	COG4264	IucA IucC family
L2Z22_08360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z22_08375	COG1960	acyl-CoA dehydrogenase activity
L2Z22_08380	COG1960	acyl-CoA dehydrogenase activity
L2Z22_08385	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z22_08390	COG2207	Transcriptional regulator
L2Z22_08395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z22_08400	COG0776	regulation of translation
L2Z22_08425	COG0822	iron-sulfur transferase activity
L2Z22_08430	COG0316	Belongs to the HesB IscA family
L2Z22_08460	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z22_08480	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z22_08485	COG0702	epimerase
L2Z22_08520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z22_08530	COG0339	signal peptide processing
L2Z22_08580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z22_08640	COG0739	heme binding
L2Z22_08640	COG0741	lytic transglycosylase activity
L2Z22_08640	COG1196	nuclear chromosome segregation
L2Z22_08700	COG4695	Portal protein
L2Z22_08785	COG0305	Participates in initiation and elongation during chromosome replication
L2Z22_08850	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z22_08880	COG0776	regulation of translation
L2Z22_08945	COG0084	hydrolase, TatD family'
L2Z22_08965	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z22_08970	COG1132	(ABC) transporter
L2Z22_08980	COG0811	peptide transport
L2Z22_08985	COG1475	DNA binding
L2Z22_08990	COG1192	Involved in chromosome partitioning
L2Z22_09000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z22_09015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z22_09020	COG0191	fructose-bisphosphate aldolase activity
L2Z22_09040	COG0424	maF-like protein
L2Z22_09045	COG2850	peptidyl-arginine hydroxylation
L2Z22_09055	COG0640	Transcriptional regulator
L2Z22_09065	COG3619	membrane
L2Z22_09070	COG3122	Protein conserved in bacteria
L2Z22_09075	COG1132	(ABC) transporter
L2Z22_09095	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z22_09100	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z22_09110	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z22_09110	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z22_09110	COG0506	proline dehydrogenase activity
L2Z22_09115	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z22_09130	COG3698	Phosphodiester glycosidase
L2Z22_09140	COG2353	YceI-like domain
L2Z22_09150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z22_09200	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z22_09200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z22_09225	COG3539	Fimbrial protein
L2Z22_09230	COG3121	Chaperone
L2Z22_09260	COG0697	spore germination
L2Z22_09270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z22_09280	COG0583	DNA-binding transcription factor activity
L2Z22_09340	COG1522	sequence-specific DNA binding
L2Z22_09350	COG1126	abc transporter atp-binding protein
L2Z22_09355	COG0765	amino acid transport
L2Z22_09360	COG0765	amino acid transport
L2Z22_09390	COG1464	Belongs to the NlpA lipoprotein family
L2Z22_09400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z22_09405	COG2011	ABC-type metal ion transport system permease component
L2Z22_09410	COG0012	GTP binding
L2Z22_09435	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z22_09475	COG0386	Belongs to the glutathione peroxidase family
L2Z22_09485	COG0436	Aminotransferase
L2Z22_09530	COG3634	alkyl hydroperoxide reductase activity
L2Z22_09545	COG0583	DNA-binding transcription factor activity
L2Z22_09550	COG0798	PFAM Bile acid sodium symporter
L2Z22_09555	COG0640	Transcriptional regulator
L2Z22_09570	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z22_09580	COG0583	DNA-binding transcription factor activity
L2Z22_09590	COG1953	Uracil, thiamine, allantoin
L2Z22_09600	COG2175	clavaminate synthase activity
L2Z22_09605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z22_09610	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z22_09615	COG4521	taurine ABC transporter
L2Z22_09635	COG0477	Major facilitator Superfamily
L2Z22_09655	COG1271	oxidase subunit
L2Z22_09660	COG1294	oxidase, subunit
L2Z22_09670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z22_09690	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z22_09710	COG3052	prosthetic group binding
L2Z22_09715	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z22_09725	COG2814	Major facilitator Superfamily
L2Z22_09745	COG1346	cytolysis
L2Z22_09755	COG0583	DNA-binding transcription factor activity
L2Z22_09760	COG0625	glutathione transferase activity
L2Z22_09765	COG0625	glutathione transferase activity
L2Z22_09770	COG0583	DNA-binding transcription factor activity
L2Z22_09790	COG1045	serine acetyltransferase
L2Z22_09930	COG0069	glutamate synthase activity
L2Z22_09950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z22_09960	COG1454	alcohol dehydrogenase
L2Z22_09965	COG0824	Thioesterase
L2Z22_09975	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z22_09990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z22_09995	COG2030	dehydratase
L2Z22_10005	COG0183	Belongs to the thiolase family
L2Z22_10015	COG0583	DNA-binding transcription factor activity
L2Z22_10020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z22_10030	COG1522	sequence-specific DNA binding
L2Z22_10035	COG3135	benzoate transporter
L2Z22_10045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z22_10070	COG0589	response to stress
L2Z22_10075	COG0488	(ABC) transporter
L2Z22_10100	COG4773	Receptor
L2Z22_10135	COG0668	transmembrane transport
L2Z22_10150	COG1309	transcriptional regulator
L2Z22_10170	COG1605	Chorismate mutase
L2Z22_10180	COG4221	oxidoreductase activity
L2Z22_10190	COG0308	aminopeptidase N
L2Z22_10210	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z22_10220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z22_10225	COG1454	alcohol dehydrogenase
L2Z22_10245	COG0531	amino acid
L2Z22_10250	COG4303	Ethanolamine ammonia lyase large subunit
L2Z22_10255	COG4302	ethanolamine ammonia-lyase activity
L2Z22_10275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z22_10285	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z22_10300	COG0697	spore germination
L2Z22_10305	COG1923	regulation of RNA biosynthetic process
L2Z22_10315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z22_10320	COG0802	atpase or kinase
L2Z22_10340	COG1187	pseudouridine synthase activity
L2Z22_10355	COG0583	DNA-binding transcription factor activity
L2Z22_10370	COG2814	Major facilitator Superfamily
L2Z22_10375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z22_10400	COG0729	surface antigen
L2Z22_10420	COG0174	glutamine synthetase
L2Z22_10425	COG0745	RESPONSE REGULATOR receiver
L2Z22_10430	COG2205	protein histidine kinase activity
L2Z22_10440	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z22_10445	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z22_10470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z22_10475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z22_10480	COG1960	acyl-CoA dehydrogenase activity
L2Z22_10495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z22_10500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z22_10520	COG0583	DNA-binding transcription factor activity
L2Z22_10535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z22_10545	COG3658	cytochrome
L2Z22_10550	COG1215	transferase activity, transferring glycosyl groups
L2Z22_10555	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z22_10555	COG0726	polysaccharide deacetylase
L2Z22_10580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z22_10585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z22_10595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z22_10620	COG0305	Participates in initiation and elongation during chromosome replication
L2Z22_10625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z22_10635	COG1305	Transglutaminase-like
L2Z22_10645	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z22_10675	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z22_10680	COG0138	bifunctional purine biosynthesis protein purh
L2Z22_10685	COG0151	Belongs to the GarS family
L2Z22_10690	COG1464	Belongs to the NlpA lipoprotein family
L2Z22_10695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z22_10700	COG2011	ABC-type metal ion transport system permease component
L2Z22_10705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z22_10715	COG1301	dicarboxylic acid transport
L2Z22_10745	COG1794	racemase activity, acting on amino acids and derivatives
L2Z22_10755	COG3008	intermembrane lipid transfer
L2Z22_10755	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z22_10760	COG2995	paraquat-inducible protein a
L2Z22_10770	COG2985	domain, Protein
L2Z22_10800	COG0477	Major facilitator Superfamily
L2Z22_10850	COG2186	Transcriptional regulator
L2Z22_10860	COG0786	glutamate:sodium symporter activity
L2Z22_10865	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z22_10920	COG4269	membrane
L2Z22_10935	COG1902	pentaerythritol trinitrate reductase activity
L2Z22_10935	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z22_10965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z22_10985	COG4172	Belongs to the ABC transporter superfamily
L2Z22_10990	COG4239	(ABC) transporter, permease
L2Z22_10995	COG4174	ABC transporter (Permease)
L2Z22_11005	COG0741	lytic transglycosylase activity
L2Z22_11005	COG1388	LysM domain
L2Z22_11005	COG0741	lytic transglycosylase activity
L2Z22_11005	COG1388	LysM domain
L2Z22_11010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z22_11050	COG0583	DNA-binding transcription factor activity
L2Z22_11055	COG1279	arginine transmembrane transporter activity
L2Z22_11075	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z22_11080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z22_11085	COG0006	proline dipeptidase activity
L2Z22_11125	COG2194	sulfuric ester hydrolase activity
L2Z22_11180	COG0739	heme binding
L2Z22_11435	COG3620	sequence-specific DNA binding
L2Z22_11500	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z22_11505	COG0308	aminopeptidase N
L2Z22_11540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z22_11550	COG0302	gtp cyclohydrolase
L2Z22_11575	COG3739	integral membrane protein
L2Z22_11590	COG1169	isochorismate synthase
L2Z22_11600	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z22_11605	COG1132	(ABC) transporter
L2Z22_11610	COG1132	(ABC) transporter
L2Z22_11620	COG1535	isochorismatase
L2Z22_11620	COG3433	isochorismatase activity
L2Z22_11625	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z22_11630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z22_11645	COG4774	siderophore transport
L2Z22_11650	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z22_11655	COG4604	ABC transporter, ATP-binding protein
L2Z22_11660	COG4605	iron ion homeostasis
L2Z22_11665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z22_11670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z22_11685	COG2964	Protein conserved in bacteria
L2Z22_11695	COG1741	Belongs to the pirin family
L2Z22_11720	COG1309	transcriptional regulator
L2Z22_11730	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z22_11735	COG2814	Major facilitator Superfamily
L2Z22_11770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z22_11770	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z22_11775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z22_11785	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_11795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z22_11800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z22_11805	COG0583	DNA-binding transcription factor activity
L2Z22_11810	COG1113	amino acid transport
L2Z22_11830	COG2508	Transcriptional regulator
L2Z22_11830	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z22_11865	COG2879	small protein
L2Z22_11870	COG1966	Carbon starvation protein
L2Z22_11915	COG1067	ATP-dependent peptidase activity
L2Z22_11920	COG0583	DNA-binding transcription factor activity
L2Z22_11945	COG1686	Belongs to the peptidase S11 family
L2Z22_11950	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z22_11985	COG0616	signal peptide processing
L2Z22_11990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z22_12000	COG0573	inorganic phosphate transmembrane transporter activity
L2Z22_12005	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z22_12015	COG1113	amino acid transport
L2Z22_12020	COG3961	Belongs to the TPP enzyme family
L2Z22_12025	COG1522	sequence-specific DNA binding
L2Z22_12035	COG0076	glutamate decarboxylase activity
L2Z22_12040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z22_12050	COG1309	transcriptional regulator
L2Z22_12065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z22_12100	COG0352	thiamine-phosphate diphosphorylase activity
L2Z22_12125	COG0612	Peptidase, M16
L2Z22_12135	COG1823	symporter activity
L2Z22_12140	COG0583	DNA-binding transcription factor activity
L2Z22_12145	COG0477	Major facilitator Superfamily
L2Z22_12170	COG1187	pseudouridine synthase activity
L2Z22_12185	COG1686	Belongs to the peptidase S11 family
L2Z22_12190	COG1252	NADH dehydrogenase
L2Z22_12200	COG0415	Belongs to the DNA photolyase family
L2Z22_12215	COG1215	transferase activity, transferring glycosyl groups
L2Z22_12245	COG2070	2-Nitropropane dioxygenase
L2Z22_12300	COG0556	nucleotide-excision repair
L2Z22_12320	COG0436	Aminotransferase
L2Z22_12350	COG4221	oxidoreductase activity
L2Z22_12360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z22_12365	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z22_12375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z22_12390	COG0681	Belongs to the peptidase S26 family
L2Z22_12405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z22_12425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z22_12430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z22_12435	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z22_12445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z22_12450	COG4208	sulfate ABC transporter
L2Z22_12455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z22_12460	COG0583	DNA-binding transcription factor activity
L2Z22_12465	COG4625	pathogenesis
L2Z22_12480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z22_12495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z22_12505	COG1051	belongs to the nudix hydrolase family
L2Z22_12505	COG1056	cytidyltransferase-related domain
L2Z22_12510	COG1024	Enoyl-CoA hydratase
L2Z22_12520	COG2814	Major facilitator Superfamily
L2Z22_12525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z22_12525	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z22_12545	COG1473	amidohydrolase
L2Z22_12550	COG0824	Thioesterase
L2Z22_12570	COG0823	Involved in the tonB-independent uptake of proteins
L2Z22_12590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z22_12635	COG0628	permease
L2Z22_12645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z22_12650	COG0596	Alpha beta hydrolase
L2Z22_12655	COG0616	signal peptide processing
L2Z22_12655	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z22_12665	COG0658	competence protein
L2Z22_12665	COG2333	competence protein COMEC
L2Z22_12670	COG1136	(ABC) transporter
L2Z22_12675	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z22_12705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z22_12725	COG0463	Glycosyl transferase, family 2
L2Z22_12755	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z22_12760	COG1280	lysine exporter protein (LysE YggA)
L2Z22_12770	COG0019	diaminopimelate decarboxylase activity
L2Z22_12780	COG1113	amino acid transport
L2Z22_12795	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z22_12805	COG3339	Conserved Protein
L2Z22_12810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z22_12815	COG0243	molybdopterin cofactor binding
L2Z22_12820	COG1929	Belongs to the glycerate kinase type-1 family
L2Z22_12835	COG0778	Nitroreductase
L2Z22_12865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z22_12885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z22_12905	COG0741	lytic transglycosylase activity
L2Z22_12925	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z22_12930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z22_12960	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z22_12965	COG1597	lipid kinase activity
L2Z22_12980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z22_12985	COG0477	Major facilitator Superfamily
L2Z22_13040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z22_13045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z22_13070	COG0505	Belongs to the CarA family
L2Z22_13090	COG0589	response to stress
L2Z22_13105	COG2843	Capsule synthesis protein
L2Z22_13135	COG2321	neutral zinc metallopeptidase
L2Z22_13140	COG2354	Protein conserved in bacteria
L2Z22_13160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z22_13185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z22_13190	COG1053	succinate dehydrogenase
L2Z22_13195	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z22_13200	COG2009	succinate dehydrogenase
L2Z22_13240	COG2921	Belongs to the UPF0250 family
L2Z22_13245	COG0321	lipoyl(octanoyl) transferase activity
L2Z22_13260	COG0531	amino acid
L2Z22_13270	COG1733	regulation of RNA biosynthetic process
L2Z22_13275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z22_13280	COG1648	precorrin-2 dehydrogenase activity
L2Z22_13280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z22_13295	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z22_13325	COG0671	phosphoesterase, PA-phosphatase related
L2Z22_13330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z22_13340	COG1538	Outer membrane efflux protein
L2Z22_13345	COG0393	Putative heavy-metal-binding
L2Z22_13350	COG0393	Putative heavy-metal-binding
L2Z22_13360	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_13370	COG0525	valine-tRNA ligase activity
L2Z22_13390	COG0583	DNA-binding transcription factor activity
L2Z22_13395	COG0004	ammonium transporteR
L2Z22_13405	COG0642	Histidine kinase
L2Z22_13410	COG0745	RESPONSE REGULATOR receiver
L2Z22_13415	COG2194	sulfuric ester hydrolase activity
L2Z22_13435	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z22_13450	COG2315	Protein conserved in bacteria
L2Z22_13455	COG0142	geranyltranstransferase activity
L2Z22_13460	COG2828	Protein conserved in bacteria
L2Z22_13465	COG1113	amino acid transport
L2Z22_13485	COG2207	Transcriptional regulator
L2Z22_13510	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z22_13530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z22_13540	COG1530	ribonuclease E activity
L2Z22_13545	COG0424	maF-like protein
L2Z22_13550	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z22_13555	COG1792	Involved in formation and maintenance of cell shape
L2Z22_13560	COG1077	Cell shape determining protein MreB Mrl
L2Z22_13565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z22_13575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z22_13615	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z22_13620	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z22_13625	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z22_13630	COG1115	amino acid carrier protein
L2Z22_13650	COG2814	Major facilitator Superfamily
L2Z22_13655	COG1289	transmembrane transporter activity
L2Z22_13665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z22_13705	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z22_13710	COG2832	Protein of unknown function (DUF454)
L2Z22_13720	COG5510	response to toxic substance
L2Z22_13740	COG0840	transmembrane signaling receptor activity
L2Z22_13780	COG3422	double-strand break repair
L2Z22_13785	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z22_13790	COG3189	MarR family transcriptional regulator
L2Z22_13800	COG0354	folic acid binding
L2Z22_13805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z22_13815	COG0679	Auxin Efflux Carrier
L2Z22_13820	COG1902	pentaerythritol trinitrate reductase activity
L2Z22_13830	COG2094	Belongs to the DNA glycosylase MPG family
L2Z22_13855	COG1217	gtp-binding protein TYPA
L2Z22_13860	COG2233	PERMEase
L2Z22_13870	COG0833	amino acid
L2Z22_13875	COG1690	Belongs to the RtcB family
L2Z22_13885	COG2885	chlorophyll binding
L2Z22_13885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z22_13895	COG0183	Belongs to the thiolase family
L2Z22_13915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z22_13935	COG2207	Transcriptional regulator
L2Z22_13940	COG0183	Belongs to the thiolase family
L2Z22_13970	COG1272	protein, Hemolysin III
L2Z22_13975	COG0477	Major facilitator Superfamily
L2Z22_13990	COG0450	alkyl hydroperoxide reductase
L2Z22_14010	COG0285	dihydrofolate synthase activity
L2Z22_14060	COG2096	Adenosyltransferase
L2Z22_14065	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z22_14080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z22_14085	COG0745	RESPONSE REGULATOR receiver
L2Z22_14090	COG2205	protein histidine kinase activity
L2Z22_14100	COG1960	acyl-CoA dehydrogenase activity
L2Z22_14105	COG1960	acyl-CoA dehydrogenase activity
L2Z22_14180	COG0438	transferase activity, transferring glycosyl groups
L2Z22_14185	COG0463	Glycosyl transferase, family 2
L2Z22_14190	COG0726	polysaccharide deacetylase
L2Z22_14210	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z22_14215	COG2205	protein histidine kinase activity
L2Z22_14245	COG1862	Preprotein translocase
L2Z22_14255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z22_14260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z22_14270	COG3781	membrane
L2Z22_14275	COG0613	PHP domain protein
L2Z22_14285	COG2350	Protein conserved in bacteria
L2Z22_14315	COG1607	acyl-coa hydrolase
L2Z22_14375	COG2199	diguanylate cyclase activity
L2Z22_14390	COG1408	metallophosphoesterase
L2Z22_14395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z22_14405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z22_14425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z22_14430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z22_14445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z22_14455	COG2969	positive regulation of protein catabolic process
L2Z22_14475	COG1960	acyl-CoA dehydrogenase activity
L2Z22_14480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z22_14495	COG1309	transcriptional regulator
L2Z22_14500	COG1960	acyl-CoA dehydrogenase activity
L2Z22_14545	COG1183	phosphatidylcholine synthase activity
L2Z22_14550	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z22_14580	COG0739	heme binding
L2Z22_14580	COG0741	lytic transglycosylase activity
L2Z22_14580	COG1196	nuclear chromosome segregation
L2Z22_14590	COG1702	phosphate starvation-inducible protein PhoH
L2Z22_14625	COG1295	ribonuclease BN
L2Z22_14630	COG0697	spore germination
L2Z22_14635	COG2169	Transcriptional regulator
L2Z22_14640	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z22_14685	COG0557	exoribonuclease II activity
L2Z22_14690	COG0339	signal peptide processing
L2Z22_14695	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z22_14725	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z22_14730	COG1960	acyl-CoA dehydrogenase activity
L2Z22_14885	COG0626	cystathionine gamma-synthase activity
L2Z22_14890	COG0433	COG0433 Predicted ATPase
L2Z22_14895	COG1017	nitric oxide dioxygenase activity
L2Z22_14895	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z22_14900	COG1959	2 iron, 2 sulfur cluster binding
L2Z22_14915	COG1301	dicarboxylic acid transport
L2Z22_14920	COG1946	Acyl-CoA thioesterase
L2Z22_14940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z22_14945	COG1040	competence protein
L2Z22_14950	COG0494	nUDIX hydrolase
L2Z22_14960	COG0598	Magnesium transport protein CorA
L2Z22_14970	COG2854	intermembrane phospholipid transfer
L2Z22_14980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z22_14985	COG1127	ABC transporter
L2Z22_14995	COG0513	Belongs to the DEAD box helicase family
L2Z22_15015	COG0408	coproporphyrinogen oxidase activity
L2Z22_15030	COG1960	acyl-CoA dehydrogenase activity
L2Z22_15040	COG1983	PspC domain protein
L2Z22_15045	COG0517	IMP dehydrogenase activity
L2Z22_15095	COG0583	DNA-binding transcription factor activity
L2Z22_15135	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_15145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z22_15150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z22_15155	COG0833	amino acid
L2Z22_15185	COG1192	Involved in chromosome partitioning
L2Z22_15190	COG0628	permease
L2Z22_15200	COG1289	transmembrane transporter activity
L2Z22_15215	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z22_15220	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z22_15230	COG0277	FAD linked oxidase domain protein
L2Z22_15235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z22_15260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z22_15265	COG5380	lipid catabolic process
L2Z22_15285	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z22_15335	COG0194	GDP metabolic process
L2Z22_15350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z22_15370	COG3307	-O-antigen
L2Z22_15390	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z22_15395	COG1704	LemA family
L2Z22_15405	COG0493	'glutamate synthase
L2Z22_15410	COG0067	glutamate synthase
L2Z22_15410	COG0070	glutamate synthase
L2Z22_15410	COG0069	glutamate synthase activity
L2Z22_15460	COG2226	methyltransferase
L2Z22_15475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z22_15480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z22_15525	COG0833	amino acid
L2Z22_15610	COG0488	(ABC) transporter
L2Z22_15615	COG2873	o-acetylhomoserine
L2Z22_15620	COG4221	oxidoreductase activity
L2Z22_15625	COG0659	secondary active sulfate transmembrane transporter activity
L2Z22_15650	COG0427	acetyl-CoA hydrolase
L2Z22_15680	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z22_15710	COG2329	Antibiotic biosynthesis monooxygenase
L2Z22_15725	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z22_15790	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z22_15795	COG1733	regulation of RNA biosynthetic process
L2Z22_15845	COG0667	Aldo Keto reductase
L2Z22_15865	COG0583	DNA-binding transcription factor activity
L2Z22_15870	COG2814	Major facilitator Superfamily
L2Z22_15905	COG4372	Transposase
L2Z22_15920	COG1335	isochorismatase
L2Z22_15930	COG1012	belongs to the aldehyde dehydrogenase family
L2Z22_15935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z22_15945	COG1113	amino acid transport
L2Z22_15955	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z22_15970	COG2814	Major facilitator Superfamily
L2Z22_15980	COG0351	phosphomethylpyrimidine kinase
L2Z22_15980	COG0352	thiamine-phosphate diphosphorylase activity
L2Z22_15980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z22_16000	COG1309	transcriptional regulator
L2Z22_16005	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z22_16035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z22_16045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z22_16050	COG3162	membrane
L2Z22_16055	COG2205	protein histidine kinase activity
L2Z22_16055	COG0784	Response regulator, receiver
L2Z22_16055	COG2198	Histidine kinase
L2Z22_16080	COG1522	sequence-specific DNA binding
L2Z22_16085	COG1335	isochorismatase
L2Z22_16090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z22_16100	COG0668	transmembrane transport
L2Z22_16105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z22_16110	COG1519	Transferase
L2Z22_16115	COG1902	pentaerythritol trinitrate reductase activity
L2Z22_16135	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z22_16160	COG0426	domain, Protein
L2Z22_16160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z22_16165	COG4774	siderophore transport
L2Z22_16170	COG2119	membrane
L2Z22_16180	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z22_16190	COG4942	peptidase
L2Z22_16205	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z22_16215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z22_16235	COG0189	ligase activity
L2Z22_16255	COG0708	Exodeoxyribonuclease III
L2Z22_16260	COG1393	Belongs to the ArsC family
L2Z22_16275	COG3706	GGDEF domain
L2Z22_16310	COG2351	hydroxyisourate hydrolase activity
L2Z22_16315	COG2233	PERMEase
L2Z22_16325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z22_16335	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z22_16340	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_16350	COG3150	esterase
L2Z22_16400	COG2918	glutathione biosynthetic process
L2Z22_16415	COG2733	membrane
L2Z22_16420	COG0436	Aminotransferase
L2Z22_16425	COG0534	Mate efflux family protein
L2Z22_16485	COG0753	catalase activity
L2Z22_16530	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z22_16535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z22_16545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z22_16590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z22_16605	COG0010	Belongs to the arginase family
L2Z22_16635	COG2188	Transcriptional regulator
L2Z22_16645	COG0523	cobalamin synthesis protein
L2Z22_16655	COG1113	amino acid transport
L2Z22_16665	COG0625	glutathione transferase activity
L2Z22_16685	COG1683	Conserved Protein
L2Z22_16690	COG0534	Mate efflux family protein
L2Z22_16695	COG0385	Bile acid
L2Z22_16700	COG1335	isochorismatase
L2Z22_16705	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z22_16725	COG2116	formate transmembrane transporter activity
L2Z22_16730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z22_16735	COG2133	pyrroloquinoline quinone binding
L2Z22_16740	COG2983	Belongs to the UPF0260 family
L2Z22_16760	COG1194	a g-specific adenine glycosylase
L2Z22_16775	COG2818	Glycosylase
L2Z22_16780	COG1064	alcohol dehydrogenase
L2Z22_16785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z22_16800	COG0583	DNA-binding transcription factor activity
L2Z22_16805	COG0656	L-ascorbic acid biosynthetic process
L2Z22_16810	COG2814	Major facilitator Superfamily
L2Z22_16845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z22_16860	COG2233	PERMEase
L2Z22_16865	COG0583	DNA-binding transcription factor activity
L2Z22_16890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L2Z22_16900	COG0733	neurotransmitter:sodium symporter activity
L2Z22_16940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z22_16945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z22_16950	COG0596	Alpha beta hydrolase
L2Z22_16975	COG0488	(ABC) transporter
L2Z22_16980	COG0586	Pfam SNARE associated Golgi protein
L2Z22_16990	COG0187	DNA topoisomerase II activity
L2Z22_17000	COG0592	DNA-directed DNA polymerase activity
L2Z22_17025	COG0706	membrane insertase activity
L2Z22_17040	COG1230	cation diffusion facilitator family transporter
L2Z22_17045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z22_17060	COG0402	S-adenosylhomocysteine deaminase activity
L2Z22_17070	COG0754	glutathionylspermidine amidase activity
L2Z22_17080	COG0861	Integral membrane protein TerC family
L2Z22_17085	COG0671	phosphoesterase, PA-phosphatase related
L2Z22_17095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z22_17115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z22_17120	COG2951	lytic endotransglycosylase activity
L2Z22_17170	COG1061	Type III restriction enzyme res subunit
L2Z22_17175	COG1002	Type II restriction enzyme, methylase subunits
L2Z22_17205	COG0657	acetylesterase activity
L2Z22_17210	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z22_17250	COG1047	Peptidyl-prolyl cis-trans
L2Z22_17260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z22_17265	COG0196	riboflavin kinase activity
L2Z22_17275	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z22_17280	COG1309	transcriptional regulator
L2Z22_17285	COG1116	anion transmembrane transporter activity
L2Z22_17290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z22_17295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z22_17300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z22_17305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z22_17325	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z22_17330	COG0546	phosphoglycolate phosphatase activity
L2Z22_17385	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z22_17390	COG0728	peptidoglycan biosynthetic process
L2Z22_17420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z22_17450	COG0438	transferase activity, transferring glycosyl groups
L2Z22_17470	COG1216	Glycosyl transferase, family 2
L2Z22_17475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z22_17480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z22_17495	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z22_17505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z22_17515	COG2186	Transcriptional regulator
L2Z22_17525	COG0277	FAD linked oxidase domain protein
L2Z22_17530	COG1448	Aminotransferase
L2Z22_17540	COG1802	Transcriptional regulator
L2Z22_17555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z22_17600	COG0564	pseudouridine synthase activity
L2Z22_17640	COG0251	oxidation-reduction process
L2Z22_17645	COG1113	amino acid transport
L2Z22_17650	COG1113	amino acid transport
L2Z22_17670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z22_17675	COG1960	acyl-CoA dehydrogenase activity
L2Z22_17680	COG1024	Enoyl-CoA hydratase
L2Z22_17685	COG1024	Enoyl-CoA hydratase
L2Z22_17690	COG0477	Major facilitator Superfamily
L2Z22_17695	COG3916	Acyl-homoserine-lactone synthase
L2Z22_17705	COG2197	response regulator
L2Z22_17715	COG1960	acyl-CoA dehydrogenase activity
L2Z22_17720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z22_17720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z22_17720	COG3321	synthase
L2Z22_17720	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z22_17760	COG0271	Belongs to the BolA IbaG family
L2Z22_17770	COG1192	Involved in chromosome partitioning
L2Z22_17785	COG0586	Pfam SNARE associated Golgi protein
L2Z22_17790	COG2259	Doxx family
L2Z22_17795	COG4399	Belongs to the UPF0754 family
L2Z22_17800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z22_17800	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z22_17855	COG0281	malic enzyme
L2Z22_17860	COG2837	iron assimilation
L2Z22_17865	COG1280	lysine exporter protein (LysE YggA)
L2Z22_17870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z22_17875	COG1121	(ABC) transporter
L2Z22_17945	COG0386	Belongs to the glutathione peroxidase family
L2Z22_17960	COG1309	transcriptional regulator
L2Z22_17965	COG0697	spore germination
L2Z22_17975	COG0758	DNA mediated transformation
L2Z22_18045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z22_18055	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z22_18095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z22_18105	COG2814	Major facilitator Superfamily
L2Z22_18115	COG1253	flavin adenine dinucleotide binding
L2Z22_18120	COG3012	SEC-C Motif Domain Protein
L2Z22_18125	COG2860	membrane
L2Z22_18130	COG0477	Major facilitator Superfamily
L2Z22_18140	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z22_18155	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z22_18175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z22_18230	COG0589	response to stress
L2Z22_18235	COG0659	secondary active sulfate transmembrane transporter activity
L2Z22_18245	COG1002	Type II restriction enzyme, methylase subunits
L2Z22_18250	COG1061	Type III restriction enzyme res subunit
L2Z22_18285	COG0347	Belongs to the P(II) protein family
L2Z22_18290	COG0004	ammonium transporteR
L2Z22_18300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z22_18300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z22_18340	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z22_18345	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z22_18350	COG0793	Belongs to the peptidase S41A family
L2Z22_18365	COG2197	response regulator
L2Z22_18375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z22_18385	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z22_18390	COG4974	Belongs to the 'phage' integrase family
L2Z22_18415	COG0772	Belongs to the SEDS family
L2Z22_18420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z22_18425	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z22_18430	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z22_18455	COG0697	spore germination
L2Z22_18460	COG1538	Outer membrane efflux protein
L2Z22_18480	COG3275	phosphorelay sensor kinase activity
L2Z22_18490	COG0181	hydroxymethylbilane synthase activity
L2Z22_18545	COG1716	ATPase activity
L2Z22_18550	COG0546	phosphoglycolate phosphatase activity
L2Z22_18650	COG0596	Alpha beta hydrolase
L2Z22_18655	COG2056	Na+-H+ antiporter family
L2Z22_18670	COG0326	Molecular chaperone. Has ATPase activity
L2Z22_18685	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z22_18755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z22_18760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z22_18760	COG2169	Transcriptional regulator
L2Z22_18790	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z22_18800	COG0497	DNA recombination
L2Z22_18815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z22_18825	COG0237	dephospho-CoA kinase activity
L2Z22_18830	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z22_18880	COG0195	Participates in both transcription termination and antitermination
L2Z22_18895	COG1320	monovalent cation:proton antiporter activity
L2Z22_18900	COG2212	antiporter activity
L2Z22_18905	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z22_18910	COG0651	ATP synthesis coupled electron transport
L2Z22_18915	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z22_18920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z22_18920	COG2111	Na H antiporter
L2Z22_18935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z22_18940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z22_18955	COG2226	methyltransferase
L2Z22_18975	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z22_18980	COG1074	ATP-dependent DNA helicase activity
L2Z22_18985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z22_18990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z22_19005	COG0598	Magnesium transport protein CorA
L2Z22_19010	COG0789	Transcriptional regulator
L2Z22_19015	COG0484	heat shock protein binding
L2Z22_19025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z22_19030	COG0475	glutathione-regulated potassium exporter activity
L2Z22_19030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z22_19035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z22_19060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z22_19070	COG4535	Mg2 and Co2 transporter CorC
L2Z22_19075	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z22_19080	COG0644	oxidoreductase
L2Z22_19080	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z22_19090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z22_19105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z22_19110	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z22_19150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis