locus-tag	class	description
L2Z29_00010	COG1607	acyl-coa hydrolase
L2Z29_00070	COG2199	diguanylate cyclase activity
L2Z29_00080	COG1408	metallophosphoesterase
L2Z29_00085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z29_00095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z29_00115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z29_00120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z29_00135	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z29_00145	COG2969	positive regulation of protein catabolic process
L2Z29_00165	COG1960	acyl-CoA dehydrogenase activity
L2Z29_00170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z29_00185	COG1309	transcriptional regulator
L2Z29_00190	COG1960	acyl-CoA dehydrogenase activity
L2Z29_00235	COG1183	phosphatidylcholine synthase activity
L2Z29_00240	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z29_00270	COG1196	nuclear chromosome segregation
L2Z29_00270	COG0741	lytic transglycosylase activity
L2Z29_00270	COG0739	heme binding
L2Z29_00280	COG1702	phosphate starvation-inducible protein PhoH
L2Z29_00315	COG1295	ribonuclease BN
L2Z29_00320	COG0697	spore germination
L2Z29_00325	COG2169	Transcriptional regulator
L2Z29_00330	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z29_00375	COG0557	exoribonuclease II activity
L2Z29_00380	COG0339	signal peptide processing
L2Z29_00385	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z29_00415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z29_00420	COG1960	acyl-CoA dehydrogenase activity
L2Z29_00575	COG0626	cystathionine gamma-synthase activity
L2Z29_00580	COG0433	COG0433 Predicted ATPase
L2Z29_00585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z29_00585	COG1017	nitric oxide dioxygenase activity
L2Z29_00590	COG1959	2 iron, 2 sulfur cluster binding
L2Z29_00605	COG1301	dicarboxylic acid transport
L2Z29_00610	COG1946	Acyl-CoA thioesterase
L2Z29_00630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z29_00635	COG1040	competence protein
L2Z29_00640	COG0494	nUDIX hydrolase
L2Z29_00650	COG0598	Magnesium transport protein CorA
L2Z29_00660	COG2854	intermembrane phospholipid transfer
L2Z29_00670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z29_00675	COG1127	ABC transporter
L2Z29_00685	COG0513	Belongs to the DEAD box helicase family
L2Z29_00705	COG0408	coproporphyrinogen oxidase activity
L2Z29_00725	COG1960	acyl-CoA dehydrogenase activity
L2Z29_00735	COG1983	PspC domain protein
L2Z29_00740	COG0517	IMP dehydrogenase activity
L2Z29_00785	COG0583	DNA-binding transcription factor activity
L2Z29_00825	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_00835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z29_00840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z29_00845	COG0833	amino acid
L2Z29_00875	COG1192	Involved in chromosome partitioning
L2Z29_00880	COG0628	permease
L2Z29_00890	COG1289	transmembrane transporter activity
L2Z29_00905	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z29_00910	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z29_00920	COG0277	FAD linked oxidase domain protein
L2Z29_00925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z29_00950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z29_00955	COG5380	lipid catabolic process
L2Z29_00975	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z29_01025	COG0194	GDP metabolic process
L2Z29_01040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z29_01060	COG3307	-O-antigen
L2Z29_01080	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z29_01085	COG1704	LemA family
L2Z29_01095	COG0493	'glutamate synthase
L2Z29_01100	COG0067	glutamate synthase
L2Z29_01100	COG0069	glutamate synthase activity
L2Z29_01100	COG0070	glutamate synthase
L2Z29_01150	COG2226	methyltransferase
L2Z29_01165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z29_01170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z29_01215	COG0833	amino acid
L2Z29_01300	COG0488	(ABC) transporter
L2Z29_01305	COG2873	o-acetylhomoserine
L2Z29_01310	COG4221	oxidoreductase activity
L2Z29_01315	COG0659	secondary active sulfate transmembrane transporter activity
L2Z29_01340	COG0427	acetyl-CoA hydrolase
L2Z29_01370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z29_01400	COG2329	Antibiotic biosynthesis monooxygenase
L2Z29_01415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z29_01480	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z29_01485	COG1733	regulation of RNA biosynthetic process
L2Z29_01520	COG0667	Aldo Keto reductase
L2Z29_01540	COG0583	DNA-binding transcription factor activity
L2Z29_01545	COG2814	Major facilitator Superfamily
L2Z29_01575	COG1335	isochorismatase
L2Z29_01585	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_01590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z29_01600	COG1113	amino acid transport
L2Z29_01610	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z29_01625	COG2814	Major facilitator Superfamily
L2Z29_01635	COG0351	phosphomethylpyrimidine kinase
L2Z29_01635	COG0352	thiamine-phosphate diphosphorylase activity
L2Z29_01635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z29_01655	COG1309	transcriptional regulator
L2Z29_01660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z29_01675	COG1002	Type II restriction enzyme, methylase subunits
L2Z29_01680	COG1061	Type III restriction enzyme res subunit
L2Z29_01715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z29_01725	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z29_01730	COG3162	membrane
L2Z29_01735	COG2198	Histidine kinase
L2Z29_01735	COG0784	Response regulator, receiver
L2Z29_01735	COG2205	protein histidine kinase activity
L2Z29_01760	COG3328	transposase activity
L2Z29_01765	COG1522	sequence-specific DNA binding
L2Z29_01770	COG1335	isochorismatase
L2Z29_01775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z29_01785	COG0668	transmembrane transport
L2Z29_01790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z29_01795	COG1519	Transferase
L2Z29_01800	COG1902	pentaerythritol trinitrate reductase activity
L2Z29_01820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z29_01845	COG0426	domain, Protein
L2Z29_01845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z29_01865	COG2119	membrane
L2Z29_01875	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z29_01885	COG4942	peptidase
L2Z29_01900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z29_01910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z29_01930	COG0189	ligase activity
L2Z29_01950	COG0708	Exodeoxyribonuclease III
L2Z29_01955	COG1393	Belongs to the ArsC family
L2Z29_01970	COG3706	GGDEF domain
L2Z29_02005	COG2351	hydroxyisourate hydrolase activity
L2Z29_02010	COG2233	PERMEase
L2Z29_02020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z29_02030	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z29_02035	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_02045	COG3150	esterase
L2Z29_02075	COG2918	glutathione biosynthetic process
L2Z29_02090	COG2733	membrane
L2Z29_02095	COG0436	Aminotransferase
L2Z29_02100	COG0534	Mate efflux family protein
L2Z29_02200	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z29_02205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z29_02215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z29_02220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z29_02235	COG0010	Belongs to the arginase family
L2Z29_02265	COG2188	Transcriptional regulator
L2Z29_02275	COG0523	cobalamin synthesis protein
L2Z29_02285	COG1113	amino acid transport
L2Z29_02295	COG0625	glutathione transferase activity
L2Z29_02315	COG1683	Conserved Protein
L2Z29_02320	COG0534	Mate efflux family protein
L2Z29_02325	COG0385	Bile acid
L2Z29_02330	COG1335	isochorismatase
L2Z29_02335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z29_02355	COG2116	formate transmembrane transporter activity
L2Z29_02360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z29_02365	COG2133	pyrroloquinoline quinone binding
L2Z29_02370	COG2983	Belongs to the UPF0260 family
L2Z29_02390	COG1194	a g-specific adenine glycosylase
L2Z29_02405	COG2818	Glycosylase
L2Z29_02410	COG1064	alcohol dehydrogenase
L2Z29_02415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z29_02430	COG0583	DNA-binding transcription factor activity
L2Z29_02435	COG0656	L-ascorbic acid biosynthetic process
L2Z29_02440	COG2814	Major facilitator Superfamily
L2Z29_02475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z29_02490	COG2233	PERMEase
L2Z29_02530	COG0733	neurotransmitter:sodium symporter activity
L2Z29_02570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z29_02575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z29_02580	COG0596	Alpha beta hydrolase
L2Z29_02605	COG0488	(ABC) transporter
L2Z29_02610	COG0586	Pfam SNARE associated Golgi protein
L2Z29_02620	COG0187	DNA topoisomerase II activity
L2Z29_02630	COG0592	DNA-directed DNA polymerase activity
L2Z29_02655	COG0706	membrane insertase activity
L2Z29_02670	COG1230	cation diffusion facilitator family transporter
L2Z29_02675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z29_02690	COG0402	S-adenosylhomocysteine deaminase activity
L2Z29_02700	COG0754	glutathionylspermidine amidase activity
L2Z29_02710	COG0861	Integral membrane protein TerC family
L2Z29_02715	COG0671	phosphoesterase, PA-phosphatase related
L2Z29_02725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z29_02740	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z29_02745	COG2951	lytic endotransglycosylase activity
L2Z29_02775	COG0583	DNA-binding transcription factor activity
L2Z29_02795	COG0657	acetylesterase activity
L2Z29_02800	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z29_02845	COG1047	Peptidyl-prolyl cis-trans
L2Z29_02855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z29_02860	COG0196	riboflavin kinase activity
L2Z29_02870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z29_02875	COG1309	transcriptional regulator
L2Z29_02880	COG1116	anion transmembrane transporter activity
L2Z29_02885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z29_02890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z29_02895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z29_02900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z29_02920	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_02925	COG0546	phosphoglycolate phosphatase activity
L2Z29_02980	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z29_02985	COG0728	peptidoglycan biosynthetic process
L2Z29_03010	COG1596	polysaccharide export
L2Z29_03015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z29_03070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z29_03075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z29_03080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z29_03095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z29_03100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z29_03110	COG2186	Transcriptional regulator
L2Z29_03120	COG0277	FAD linked oxidase domain protein
L2Z29_03125	COG1448	Aminotransferase
L2Z29_03135	COG1802	Transcriptional regulator
L2Z29_03150	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z29_03220	COG0564	pseudouridine synthase activity
L2Z29_03260	COG0251	oxidation-reduction process
L2Z29_03265	COG1113	amino acid transport
L2Z29_03270	COG1113	amino acid transport
L2Z29_03290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z29_03295	COG1960	acyl-CoA dehydrogenase activity
L2Z29_03300	COG1024	Enoyl-CoA hydratase
L2Z29_03305	COG1024	Enoyl-CoA hydratase
L2Z29_03310	COG0477	Major facilitator Superfamily
L2Z29_03315	COG0019	diaminopimelate decarboxylase activity
L2Z29_03320	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z29_03330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z29_03335	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L2Z29_03340	COG1846	Transcriptional regulator
L2Z29_03345	COG3916	Acyl-homoserine-lactone synthase
L2Z29_03355	COG2197	response regulator
L2Z29_03365	COG1960	acyl-CoA dehydrogenase activity
L2Z29_03370	COG3321	synthase
L2Z29_03370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z29_03370	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z29_03370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z29_03410	COG0271	Belongs to the BolA IbaG family
L2Z29_03420	COG1192	Involved in chromosome partitioning
L2Z29_03435	COG0586	Pfam SNARE associated Golgi protein
L2Z29_03440	COG2259	Doxx family
L2Z29_03445	COG4399	Belongs to the UPF0754 family
L2Z29_03450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z29_03450	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z29_03495	COG0281	malic enzyme
L2Z29_03500	COG2837	iron assimilation
L2Z29_03505	COG1280	lysine exporter protein (LysE YggA)
L2Z29_03510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z29_03515	COG1121	(ABC) transporter
L2Z29_03580	COG0386	Belongs to the glutathione peroxidase family
L2Z29_03595	COG1309	transcriptional regulator
L2Z29_03600	COG0697	spore germination
L2Z29_03610	COG0758	DNA mediated transformation
L2Z29_03680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z29_03690	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z29_03730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z29_03750	COG1253	flavin adenine dinucleotide binding
L2Z29_03760	COG2860	membrane
L2Z29_03765	COG0477	Major facilitator Superfamily
L2Z29_03775	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z29_03790	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z29_03810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z29_03820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z29_03865	COG0589	response to stress
L2Z29_03870	COG0659	secondary active sulfate transmembrane transporter activity
L2Z29_03930	COG0347	Belongs to the P(II) protein family
L2Z29_03935	COG0004	ammonium transporteR
L2Z29_03945	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z29_03945	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z29_03990	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z29_03995	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z29_04000	COG0793	Belongs to the peptidase S41A family
L2Z29_04015	COG2197	response regulator
L2Z29_04025	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z29_04035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z29_04040	COG4974	Belongs to the 'phage' integrase family
L2Z29_04065	COG0772	Belongs to the SEDS family
L2Z29_04070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z29_04075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z29_04080	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z29_04105	COG0697	spore germination
L2Z29_04110	COG1538	Outer membrane efflux protein
L2Z29_04130	COG3275	phosphorelay sensor kinase activity
L2Z29_04140	COG0181	hydroxymethylbilane synthase activity
L2Z29_04185	COG1716	ATPase activity
L2Z29_04190	COG0546	phosphoglycolate phosphatase activity
L2Z29_04285	COG0596	Alpha beta hydrolase
L2Z29_04290	COG2056	Na+-H+ antiporter family
L2Z29_04305	COG0326	Molecular chaperone. Has ATPase activity
L2Z29_04320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z29_04385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z29_04390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z29_04390	COG2169	Transcriptional regulator
L2Z29_04420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z29_04430	COG0497	DNA recombination
L2Z29_04445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z29_04455	COG0237	dephospho-CoA kinase activity
L2Z29_04460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z29_04510	COG0195	Participates in both transcription termination and antitermination
L2Z29_04525	COG1320	monovalent cation:proton antiporter activity
L2Z29_04530	COG2212	antiporter activity
L2Z29_04535	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z29_04540	COG0651	ATP synthesis coupled electron transport
L2Z29_04545	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z29_04550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z29_04550	COG2111	Na H antiporter
L2Z29_04565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z29_04570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z29_04585	COG2226	methyltransferase
L2Z29_04605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z29_04610	COG1074	ATP-dependent DNA helicase activity
L2Z29_04615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z29_04620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z29_04635	COG0598	Magnesium transport protein CorA
L2Z29_04640	COG0789	Transcriptional regulator
L2Z29_04645	COG0484	heat shock protein binding
L2Z29_04655	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z29_04660	COG0475	glutathione-regulated potassium exporter activity
L2Z29_04660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z29_04665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z29_04685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z29_04695	COG4535	Mg2 and Co2 transporter CorC
L2Z29_04700	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z29_04705	COG0644	oxidoreductase
L2Z29_04705	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z29_04715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z29_04730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z29_04735	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z29_04775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z29_04790	COG0534	Mate efflux family protein
L2Z29_04800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z29_04805	COG4221	oxidoreductase activity
L2Z29_04810	COG0583	DNA-binding transcription factor activity
L2Z29_04825	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z29_04830	COG1530	ribonuclease E activity
L2Z29_04840	COG0546	phosphoglycolate phosphatase activity
L2Z29_04845	COG2378	regulation of single-species biofilm formation
L2Z29_04850	COG0625	glutathione transferase activity
L2Z29_04860	COG0583	DNA-binding transcription factor activity
L2Z29_04925	COG0473	3-isopropylmalate dehydrogenase activity
L2Z29_04980	COG1301	dicarboxylic acid transport
L2Z29_04990	COG1560	Kdo2-lipid A biosynthetic process
L2Z29_04995	COG1280	lysine exporter protein (LysE YggA)
L2Z29_05000	COG0488	(ABC) transporter
L2Z29_05005	COG2900	Belongs to the SlyX family
L2Z29_05015	COG1733	regulation of RNA biosynthetic process
L2Z29_05040	COG0210	DNA helicase
L2Z29_05045	COG0724	RNA recognition motif
L2Z29_05065	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z29_05065	COG4651	solute:proton antiporter activity
L2Z29_05090	COG0788	formyltetrahydrofolate deformylase activity
L2Z29_05190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z29_05190	COG2813	Specifically methylates the guanine in position
L2Z29_05200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z29_05210	COG4774	siderophore transport
L2Z29_05220	COG0740	serine-type endopeptidase activity
L2Z29_05240	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z29_05240	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z29_05245	COG0857	belongs to the CobB CobQ family
L2Z29_05245	COG0280	phosphate acetyltransferase
L2Z29_05250	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z29_05260	COG0800	Aldolase
L2Z29_05270	COG3265	gluconokinase activity
L2Z29_05275	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_05285	COG2267	carboxylic ester hydrolase activity
L2Z29_05300	COG0793	Belongs to the peptidase S41A family
L2Z29_05335	COG1426	Protein conserved in bacteria
L2Z29_05380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z29_05390	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z29_05405	COG2986	histidine ammonia-lyase
L2Z29_05445	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_05450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z29_05470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z29_05480	COG1162	GTPase activity
L2Z29_05485	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z29_05500	COG1538	Outer membrane efflux protein
L2Z29_05505	COG1136	(ABC) transporter
L2Z29_05505	COG0577	efflux transmembrane transporter activity
L2Z29_05510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z29_05535	COG0028	Belongs to the TPP enzyme family
L2Z29_05540	COG0440	acetolactate synthase activity
L2Z29_05570	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z29_05585	COG0084	hydrolase, TatD family'
L2Z29_05600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z29_05610	COG0583	DNA-binding transcription factor activity
L2Z29_05620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z29_05625	COG2814	Major facilitator Superfamily
L2Z29_05635	COG0697	spore germination
L2Z29_05665	COG3622	Belongs to the hyi family
L2Z29_05670	COG2084	Dehydrogenase
L2Z29_05675	COG1024	Enoyl-CoA hydratase
L2Z29_05680	COG2205	protein histidine kinase activity
L2Z29_05680	COG5002	protein histidine kinase activity
L2Z29_05680	COG0784	Response regulator, receiver
L2Z29_05700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z29_05710	COG3956	TIGRFAM MazG family protein
L2Z29_05715	COG1555	photosystem II stabilization
L2Z29_05720	COG0617	tRNA 3'-terminal CCA addition
L2Z29_05725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z29_05745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z29_05750	COG3028	Belongs to the UPF0307 family
L2Z29_05755	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z29_05770	COG0625	glutathione transferase activity
L2Z29_05775	COG1238	metal cluster binding
L2Z29_05820	COG0072	phenylalanine-tRNA ligase activity
L2Z29_05850	COG0248	Ppx GppA phosphatase
L2Z29_05860	COG0037	tRNA processing
L2Z29_05900	COG1764	response to oxidative stress
L2Z29_05905	COG1846	Transcriptional regulator
L2Z29_05915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z29_05975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z29_05980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z29_05985	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z29_05995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z29_06045	COG1214	PFAM Peptidase M22, glycoprotease
L2Z29_06070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z29_06075	COG0561	phosphatase activity
L2Z29_06085	COG2132	Multicopper oxidase
L2Z29_06090	COG3667	copper resistance
L2Z29_06105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z29_06110	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z29_06115	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z29_06145	COG1063	alcohol dehydrogenase
L2Z29_06150	COG0583	DNA-binding transcription factor activity
L2Z29_06155	COG1960	acyl-CoA dehydrogenase activity
L2Z29_06160	COG2814	Major facilitator Superfamily
L2Z29_06165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z29_06175	COG1053	succinate dehydrogenase
L2Z29_06180	COG0583	DNA-binding transcription factor activity
L2Z29_06195	COG0583	DNA-binding transcription factor activity
L2Z29_06225	COG0583	DNA-binding transcription factor activity
L2Z29_06240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z29_06265	COG0384	phenazine biosynthesis protein PhzF
L2Z29_06290	COG4993	Dehydrogenase
L2Z29_06355	COG2205	protein histidine kinase activity
L2Z29_06365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z29_06385	COG0745	RESPONSE REGULATOR receiver
L2Z29_06425	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z29_06455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z29_06460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z29_06480	COG0583	DNA-binding transcription factor activity
L2Z29_06500	COG0668	transmembrane transport
L2Z29_06510	COG2081	HI0933 family
L2Z29_06515	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z29_06545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z29_06545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z29_06555	COG0489	protein tyrosine kinase activity
L2Z29_06605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z29_06615	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z29_06630	COG0730	response to heat
L2Z29_06640	COG1196	nuclear chromosome segregation
L2Z29_06660	COG2223	nitrite transmembrane transporter activity
L2Z29_06665	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z29_06670	COG1877	trehalose-phosphatase activity
L2Z29_06675	COG2226	methyltransferase
L2Z29_06675	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z29_06675	COG0596	Alpha beta hydrolase
L2Z29_06690	COG4106	trans-aconitate 2-methyltransferase activity
L2Z29_06705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z29_06710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z29_06715	COG0009	L-threonylcarbamoyladenylate synthase
L2Z29_06720	COG3101	peptidyl-lysine hydroxylation
L2Z29_06725	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z29_06750	COG1652	LysM domain
L2Z29_06755	COG0351	phosphomethylpyrimidine kinase
L2Z29_06755	COG0352	thiamine-phosphate diphosphorylase activity
L2Z29_06755	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z29_06765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z29_06795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z29_06825	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z29_06840	COG0358	DNA primase activity
L2Z29_06850	COG0564	pseudouridine synthase activity
L2Z29_06875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z29_06895	COG0583	DNA-binding transcription factor activity
L2Z29_06900	COG0473	3-isopropylmalate dehydrogenase activity
L2Z29_06920	COG0657	acetylesterase activity
L2Z29_06930	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_06950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z29_06950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z29_06965	COG1981	membrane
L2Z29_07010	COG0456	acetyltransferase
L2Z29_07020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z29_07025	COG0492	ferredoxin-NADP+ reductase activity
L2Z29_07030	COG1674	ftsk spoiiie
L2Z29_07030	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z29_07035	COG1280	lysine exporter protein (LysE YggA)
L2Z29_07060	COG2894	cell division
L2Z29_07075	COG0204	Acyl-transferase
L2Z29_07080	COG2885	chlorophyll binding
L2Z29_07085	COG0210	DNA helicase
L2Z29_07095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z29_07110	COG0121	glutamine amidotransferase
L2Z29_07130	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z29_07135	COG0735	belongs to the Fur family
L2Z29_07160	COG0420	3'-5' exonuclease activity
L2Z29_07180	COG1090	epimerase
L2Z29_07195	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z29_07205	COG2814	Major facilitator Superfamily
L2Z29_07210	COG0405	Gamma-glutamyltransferase
L2Z29_07250	COG0477	Major facilitator Superfamily
L2Z29_07255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z29_07280	COG0531	amino acid
L2Z29_07285	COG2040	homocysteine
L2Z29_07310	COG1309	transcriptional regulator
L2Z29_07315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z29_07320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z29_07330	COG1607	acyl-coa hydrolase
L2Z29_07340	COG0523	cobalamin synthesis protein
L2Z29_07350	COG4681	YaeQ
L2Z29_07360	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z29_07360	COG0726	polysaccharide deacetylase
L2Z29_07365	COG1215	transferase activity, transferring glycosyl groups
L2Z29_07375	COG1024	Enoyl-CoA hydratase
L2Z29_07390	COG1414	Transcriptional regulator
L2Z29_07410	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_07420	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z29_07425	COG2271	Major facilitator Superfamily
L2Z29_07435	COG2267	carboxylic ester hydrolase activity
L2Z29_07440	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_07455	COG0028	Belongs to the TPP enzyme family
L2Z29_07465	COG0477	Major facilitator Superfamily
L2Z29_07470	COG0242	peptide deformylase activity
L2Z29_07475	COG2066	Belongs to the glutaminase family
L2Z29_07480	COG2207	Transcriptional regulator
L2Z29_07485	COG2223	nitrite transmembrane transporter activity
L2Z29_07500	COG0583	DNA-binding transcription factor activity
L2Z29_07505	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_07510	COG2271	Major facilitator Superfamily
L2Z29_07515	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z29_07520	COG3958	Transketolase
L2Z29_07530	COG0306	phosphate transporter
L2Z29_07550	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z29_07595	COG4181	ATPase activity
L2Z29_07600	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z29_07625	COG0583	DNA-binding transcription factor activity
L2Z29_07635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z29_07640	COG1773	rubredoxin
L2Z29_07745	COG0488	(ABC) transporter
L2Z29_07750	COG3173	Aminoglycoside phosphotransferase
L2Z29_07760	COG2433	Pfam Transposase IS66
L2Z29_07785	COG1301	dicarboxylic acid transport
L2Z29_07795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z29_07800	COG2011	ABC-type metal ion transport system permease component
L2Z29_07805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z29_07810	COG1464	Belongs to the NlpA lipoprotein family
L2Z29_07815	COG0151	Belongs to the GarS family
L2Z29_07820	COG0138	bifunctional purine biosynthesis protein purh
L2Z29_07825	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z29_07855	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z29_07865	COG1305	Transglutaminase-like
L2Z29_07875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z29_07880	COG0305	Participates in initiation and elongation during chromosome replication
L2Z29_07905	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z29_07915	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z29_07920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z29_07945	COG0726	polysaccharide deacetylase
L2Z29_07945	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z29_07950	COG1215	transferase activity, transferring glycosyl groups
L2Z29_07955	COG3658	cytochrome
L2Z29_07965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z29_07980	COG0583	DNA-binding transcription factor activity
L2Z29_08000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z29_08005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z29_08020	COG1960	acyl-CoA dehydrogenase activity
L2Z29_08025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z29_08030	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z29_08055	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z29_08060	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z29_08070	COG2205	protein histidine kinase activity
L2Z29_08075	COG0745	RESPONSE REGULATOR receiver
L2Z29_08080	COG0174	glutamine synthetase
L2Z29_08100	COG0729	surface antigen
L2Z29_08125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z29_08130	COG2814	Major facilitator Superfamily
L2Z29_08145	COG0583	DNA-binding transcription factor activity
L2Z29_08160	COG1187	pseudouridine synthase activity
L2Z29_08180	COG0802	atpase or kinase
L2Z29_08185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z29_08195	COG1923	regulation of RNA biosynthetic process
L2Z29_08200	COG0697	spore germination
L2Z29_08215	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z29_08225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z29_08230	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z29_08230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z29_08235	COG4302	ethanolamine ammonia-lyase activity
L2Z29_08240	COG4303	Ethanolamine ammonia lyase large subunit
L2Z29_08245	COG0531	amino acid
L2Z29_08265	COG1454	alcohol dehydrogenase
L2Z29_08270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z29_08280	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z29_08300	COG0308	aminopeptidase N
L2Z29_08310	COG4221	oxidoreductase activity
L2Z29_08320	COG1605	Chorismate mutase
L2Z29_08340	COG1309	transcriptional regulator
L2Z29_08350	COG0668	transmembrane transport
L2Z29_08385	COG4773	Receptor
L2Z29_08405	COG0488	(ABC) transporter
L2Z29_08410	COG0589	response to stress
L2Z29_08435	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z29_08445	COG3135	benzoate transporter
L2Z29_08450	COG1522	sequence-specific DNA binding
L2Z29_08460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z29_08465	COG0583	DNA-binding transcription factor activity
L2Z29_08475	COG0183	Belongs to the thiolase family
L2Z29_08485	COG2030	dehydratase
L2Z29_08490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z29_08505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z29_08515	COG0824	Thioesterase
L2Z29_08520	COG1454	alcohol dehydrogenase
L2Z29_08530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z29_08550	COG0069	glutamate synthase activity
L2Z29_08610	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z29_08700	COG1484	DNA-dependent DNA replication
L2Z29_08895	COG2026	Addiction module toxin, RelE StbE family
L2Z29_08935	COG0592	DNA-directed DNA polymerase activity
L2Z29_09055	COG2814	Major facilitator Superfamily
L2Z29_09070	COG0511	ligase activity, forming carbon-carbon bonds
L2Z29_09090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z29_09090	COG1116	anion transmembrane transporter activity
L2Z29_09095	COG0745	RESPONSE REGULATOR receiver
L2Z29_09105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z29_09105	COG2146	nitrite reductase [NAD(P)H] activity
L2Z29_09110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z29_09115	COG0243	molybdopterin cofactor binding
L2Z29_09125	COG0243	molybdopterin cofactor binding
L2Z29_09130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z29_09145	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z29_09145	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z29_09150	COG0303	'Molybdopterin
L2Z29_09160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z29_09165	COG0697	spore germination
L2Z29_09185	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z29_09190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z29_09245	COG2204	response regulator
L2Z29_09250	COG3852	Histidine kinase
L2Z29_09270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z29_09275	COG0575	Belongs to the CDS family
L2Z29_09310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z29_09325	COG2137	regulation of response to DNA damage stimulus
L2Z29_09335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z29_09340	COG1011	Hydrolase
L2Z29_09365	COG1522	sequence-specific DNA binding
L2Z29_09375	COG1113	amino acid transport
L2Z29_09395	COG0659	secondary active sulfate transmembrane transporter activity
L2Z29_09400	COG2135	peptidase activity
L2Z29_09415	COG3300	MHYT domain
L2Z29_09415	COG5001	Diguanylate cyclase
L2Z29_09435	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z29_09435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z29_09435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z29_09440	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z29_09445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z29_09445	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z29_09475	COG0024	Methionine aminopeptidase
L2Z29_09480	COG0583	DNA-binding transcription factor activity
L2Z29_09490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z29_09495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z29_09500	COG0517	IMP dehydrogenase activity
L2Z29_09500	COG0516	GMP reductase activity
L2Z29_09525	COG0552	protein localization to endoplasmic reticulum
L2Z29_09535	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z29_09550	COG4890	Cyd operon protein YbgT
L2Z29_09555	COG1294	oxidase, subunit
L2Z29_09575	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z29_09585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z29_09590	COG4774	siderophore transport
L2Z29_09605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z29_09610	COG0569	domain protein
L2Z29_09615	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z29_09645	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z29_09650	COG0542	response to heat
L2Z29_09675	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z29_09675	COG1902	pentaerythritol trinitrate reductase activity
L2Z29_09720	COG2323	membrane
L2Z29_09725	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z29_09735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z29_09740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z29_09745	COG0183	Belongs to the thiolase family
L2Z29_09750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z29_09755	COG0596	Alpha beta hydrolase
L2Z29_09760	COG2271	Major facilitator Superfamily
L2Z29_09765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z29_09770	COG3485	protocatechuate 3,4-dioxygenase
L2Z29_09775	COG3485	protocatechuate 3,4-dioxygenase
L2Z29_09780	COG0710	3-dehydroquinate dehydratase activity
L2Z29_09785	COG3420	alginic acid biosynthetic process
L2Z29_09790	COG3659	wide pore channel activity
L2Z29_09795	COG4993	Dehydrogenase
L2Z29_09805	COG2391	methyltransferase activity
L2Z29_09820	COG1414	Transcriptional regulator
L2Z29_09825	COG0583	DNA-binding transcription factor activity
L2Z29_09830	COG1960	acyl-CoA dehydrogenase activity
L2Z29_09855	COG2814	Major facilitator Superfamily
L2Z29_09865	COG0154	amidase activity
L2Z29_09885	COG4638	Rieske (2fe-2S)
L2Z29_09895	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_09905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z29_09915	COG3733	amine oxidase
L2Z29_09925	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_09935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z29_09940	COG0183	Belongs to the thiolase family
L2Z29_09945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z29_09950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z29_09960	COG4829	muconolactone delta-isomerase
L2Z29_09965	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z29_09970	COG0583	DNA-binding transcription factor activity
L2Z29_09980	COG2186	Transcriptional regulator
L2Z29_10000	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_10020	COG1960	acyl-CoA dehydrogenase activity
L2Z29_10025	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_10030	COG3829	transcription factor binding
L2Z29_10040	COG3162	membrane
L2Z29_10055	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_10070	COG0753	catalase activity
L2Z29_10090	COG1846	Transcriptional regulator
L2Z29_10095	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z29_10095	COG1902	pentaerythritol trinitrate reductase activity
L2Z29_10105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z29_10135	COG1309	transcriptional regulator
L2Z29_10145	COG1335	isochorismatase
L2Z29_10150	COG0583	DNA-binding transcription factor activity
L2Z29_10160	COG0475	glutathione-regulated potassium exporter activity
L2Z29_10160	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z29_10170	COG1473	amidohydrolase
L2Z29_10180	COG2831	hemolysin activation secretion protein
L2Z29_10225	COG2188	Transcriptional regulator
L2Z29_10240	COG0583	DNA-binding transcription factor activity
L2Z29_10270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z29_10300	COG1566	PFAM secretion protein HlyD family protein
L2Z29_10315	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_10320	COG0129	dihydroxy-acid dehydratase activity
L2Z29_10330	COG0583	DNA-binding transcription factor activity
L2Z29_10335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z29_10345	COG2084	Dehydrogenase
L2Z29_10350	COG2207	Transcriptional regulator
L2Z29_10365	COG1064	alcohol dehydrogenase
L2Z29_10375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z29_10380	COG1120	ATPase activity
L2Z29_10400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z29_10520	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z29_10570	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_10585	COG2207	Transcriptional regulator
L2Z29_10595	COG2205	protein histidine kinase activity
L2Z29_10600	COG0745	RESPONSE REGULATOR receiver
L2Z29_10610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z29_10615	COG1538	Outer membrane efflux protein
L2Z29_10625	COG2072	flavoprotein involved in K transport
L2Z29_10645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z29_10665	COG3539	Fimbrial protein
L2Z29_10695	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z29_10705	COG0753	catalase activity
L2Z29_10720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z29_10780	COG3433	isochorismatase activity
L2Z29_10780	COG1535	isochorismatase
L2Z29_10785	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_10790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z29_10795	COG4149	molybdate abc transporter
L2Z29_10800	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z29_10810	COG4638	Rieske (2fe-2S)
L2Z29_10815	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z29_10820	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z29_10820	COG0543	2 iron, 2 sulfur cluster binding
L2Z29_10845	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_10860	COG2207	Transcriptional regulator
L2Z29_10870	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_10875	COG2610	gluconate transmembrane transporter activity
L2Z29_10885	COG0583	DNA-binding transcription factor activity
L2Z29_10895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z29_10900	COG2031	fatty acid transporter
L2Z29_10905	COG0183	Belongs to the thiolase family
L2Z29_10910	COG0583	DNA-binding transcription factor activity
L2Z29_10915	COG0583	DNA-binding transcription factor activity
L2Z29_10930	COG1027	Aspartate ammonia-lyase
L2Z29_10940	COG0477	Major facilitator Superfamily
L2Z29_10960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z29_10965	COG4521	taurine ABC transporter
L2Z29_10980	COG2188	Transcriptional regulator
L2Z29_10990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z29_10995	COG1733	regulation of RNA biosynthetic process
L2Z29_11000	COG3708	Transcriptional regulator
L2Z29_11000	COG2207	Transcriptional regulator
L2Z29_11015	COG0730	response to heat
L2Z29_11030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z29_11030	COG3453	Protein conserved in bacteria
L2Z29_11040	COG3781	membrane
L2Z29_11045	COG1063	alcohol dehydrogenase
L2Z29_11055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z29_11060	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z29_11065	COG0022	dehydrogenase e1 component
L2Z29_11070	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z29_11075	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z29_11090	COG3706	GGDEF domain
L2Z29_11105	COG0133	tryptophan synthase activity
L2Z29_11115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z29_11150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z29_11175	COG2226	methyltransferase
L2Z29_11230	COG0842	Transport permease protein
L2Z29_11235	COG0842	Transport permease protein
L2Z29_11240	COG1131	(ABC) transporter
L2Z29_11255	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z29_11260	COG4773	Receptor
L2Z29_11280	COG0730	response to heat
L2Z29_11285	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z29_11305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z29_11320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z29_11360	COG4264	IucA IucC family
L2Z29_11365	COG4264	IucA IucC family
L2Z29_11385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z29_11400	COG1960	acyl-CoA dehydrogenase activity
L2Z29_11405	COG1960	acyl-CoA dehydrogenase activity
L2Z29_11410	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z29_11415	COG2207	Transcriptional regulator
L2Z29_11420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z29_11425	COG0776	regulation of translation
L2Z29_11450	COG0822	iron-sulfur transferase activity
L2Z29_11455	COG0316	Belongs to the HesB IscA family
L2Z29_11485	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z29_11505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z29_11510	COG0702	epimerase
L2Z29_11545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z29_11555	COG0339	signal peptide processing
L2Z29_11605	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z29_11610	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z29_11640	COG0776	regulation of translation
L2Z29_11705	COG0084	hydrolase, TatD family'
L2Z29_11725	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z29_11730	COG1132	(ABC) transporter
L2Z29_11740	COG0811	peptide transport
L2Z29_11745	COG1475	DNA binding
L2Z29_11750	COG1192	Involved in chromosome partitioning
L2Z29_11760	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z29_11775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z29_11780	COG0191	fructose-bisphosphate aldolase activity
L2Z29_11800	COG0424	maF-like protein
L2Z29_11805	COG2850	peptidyl-arginine hydroxylation
L2Z29_11815	COG0640	Transcriptional regulator
L2Z29_11825	COG3619	membrane
L2Z29_11830	COG3122	Protein conserved in bacteria
L2Z29_11835	COG1132	(ABC) transporter
L2Z29_11855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z29_11860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z29_11870	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z29_11870	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z29_11870	COG0506	proline dehydrogenase activity
L2Z29_11875	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z29_11890	COG3698	Phosphodiester glycosidase
L2Z29_11900	COG2353	YceI-like domain
L2Z29_11910	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z29_11955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z29_11955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z29_11980	COG3539	Fimbrial protein
L2Z29_11985	COG3121	Chaperone
L2Z29_12010	COG0697	spore germination
L2Z29_12020	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z29_12030	COG0583	DNA-binding transcription factor activity
L2Z29_12050	COG1309	transcriptional regulator
L2Z29_12065	COG1522	sequence-specific DNA binding
L2Z29_12075	COG1126	abc transporter atp-binding protein
L2Z29_12080	COG0765	amino acid transport
L2Z29_12085	COG0765	amino acid transport
L2Z29_12115	COG1464	Belongs to the NlpA lipoprotein family
L2Z29_12125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z29_12130	COG2011	ABC-type metal ion transport system permease component
L2Z29_12135	COG0012	GTP binding
L2Z29_12160	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z29_12200	COG0386	Belongs to the glutathione peroxidase family
L2Z29_12210	COG0436	Aminotransferase
L2Z29_12250	COG3634	alkyl hydroperoxide reductase activity
L2Z29_12265	COG0583	DNA-binding transcription factor activity
L2Z29_12270	COG0798	PFAM Bile acid sodium symporter
L2Z29_12275	COG0640	Transcriptional regulator
L2Z29_12310	COG0583	DNA-binding transcription factor activity
L2Z29_12320	COG1953	Uracil, thiamine, allantoin
L2Z29_12330	COG2175	clavaminate synthase activity
L2Z29_12335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z29_12340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z29_12345	COG4521	taurine ABC transporter
L2Z29_12355	COG0477	Major facilitator Superfamily
L2Z29_12375	COG1271	oxidase subunit
L2Z29_12380	COG1294	oxidase, subunit
L2Z29_12390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z29_12410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z29_12430	COG3052	prosthetic group binding
L2Z29_12435	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z29_12445	COG2814	Major facilitator Superfamily
L2Z29_12465	COG1346	cytolysis
L2Z29_12475	COG0583	DNA-binding transcription factor activity
L2Z29_12480	COG0625	glutathione transferase activity
L2Z29_12485	COG0625	glutathione transferase activity
L2Z29_12490	COG0583	DNA-binding transcription factor activity
L2Z29_12505	COG1045	serine acetyltransferase
L2Z29_12510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z29_12515	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z29_12525	COG1280	lysine exporter protein (LysE YggA)
L2Z29_12540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z29_12545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z29_12550	COG1126	abc transporter atp-binding protein
L2Z29_12555	COG0765	amino acid transport
L2Z29_12560	COG0765	amino acid transport
L2Z29_12580	COG0784	Response regulator, receiver
L2Z29_12580	COG2205	protein histidine kinase activity
L2Z29_12600	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z29_12620	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_12670	COG0583	DNA-binding transcription factor activity
L2Z29_12690	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z29_12695	COG1309	transcriptional regulator
L2Z29_12700	COG1960	acyl-CoA dehydrogenase activity
L2Z29_12705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z29_12710	COG1024	Enoyl-CoA hydratase
L2Z29_12715	COG4770	biotin carboxylase activity
L2Z29_12725	COG0583	DNA-binding transcription factor activity
L2Z29_12740	COG1960	acyl-CoA dehydrogenase activity
L2Z29_12750	COG2814	Major facilitator Superfamily
L2Z29_12760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z29_12765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z29_12770	COG2814	Major facilitator Superfamily
L2Z29_12775	COG1960	acyl-CoA dehydrogenase activity
L2Z29_12780	COG1024	Enoyl-CoA hydratase
L2Z29_12785	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_12790	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z29_12795	COG0183	Belongs to the thiolase family
L2Z29_12805	COG2814	Major facilitator Superfamily
L2Z29_12815	COG1024	Enoyl-CoA hydratase
L2Z29_12830	COG1960	acyl-CoA dehydrogenase activity
L2Z29_12835	COG2814	Major facilitator Superfamily
L2Z29_12840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z29_12845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z29_12860	COG3842	ATPase activity
L2Z29_12865	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z29_12875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z29_12880	COG1414	Transcriptional regulator
L2Z29_12890	COG0583	DNA-binding transcription factor activity
L2Z29_12895	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z29_12900	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_12910	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z29_12920	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_12925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z29_12930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z29_12935	COG2267	carboxylic ester hydrolase activity
L2Z29_12955	COG3038	cytochrome b561
L2Z29_12960	COG0753	catalase activity
L2Z29_12995	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z29_13005	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z29_13010	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z29_13015	COG0183	Belongs to the thiolase family
L2Z29_13020	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z29_13025	COG1024	Enoyl-CoA hydratase
L2Z29_13030	COG1024	Enoyl-CoA hydratase
L2Z29_13035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z29_13040	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z29_13045	COG3396	Phenylacetate-CoA oxygenase
L2Z29_13050	COG3460	Phenylacetate-CoA oxygenase
L2Z29_13055	COG3396	Phenylacetate-CoA oxygenase
L2Z29_13060	COG2030	dehydratase
L2Z29_13060	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_13065	COG1760	l-serine dehydratase
L2Z29_13070	COG0531	amino acid
L2Z29_13075	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_13090	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z29_13100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z29_13120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z29_13130	COG0789	Transcriptional regulator
L2Z29_13145	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z29_13160	COG2807	transmembrane transport
L2Z29_13165	COG0590	tRNA wobble adenosine to inosine editing
L2Z29_13285	COG1116	anion transmembrane transporter activity
L2Z29_13290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z29_13300	COG0864	Transcriptional regulator
L2Z29_13320	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z29_13325	COG0439	Biotin carboxylase
L2Z29_13340	COG1063	alcohol dehydrogenase
L2Z29_13350	COG1309	transcriptional regulator
L2Z29_13370	COG0038	chloride channel
L2Z29_13375	COG4770	biotin carboxylase activity
L2Z29_13395	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z29_13400	COG0583	DNA-binding transcription factor activity
L2Z29_13450	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z29_13470	COG2814	Major facilitator Superfamily
L2Z29_13485	COG1560	Kdo2-lipid A biosynthetic process
L2Z29_13495	COG5006	permease, DMT superfamily
L2Z29_13500	COG1522	sequence-specific DNA binding
L2Z29_13515	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z29_13525	COG4122	O-methyltransferase activity
L2Z29_13555	COG1538	Outer membrane efflux protein
L2Z29_13560	COG1137	ATPase activity
L2Z29_13565	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z29_13575	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z29_13580	COG0517	IMP dehydrogenase activity
L2Z29_13580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z29_13615	COG2814	Major facilitator Superfamily
L2Z29_13650	COG1278	Cold shock
L2Z29_13655	COG1280	lysine exporter protein (LysE YggA)
L2Z29_13685	COG1570	exodeoxyribonuclease VII activity
L2Z29_13735	COG0583	DNA-binding transcription factor activity
L2Z29_13745	COG4638	Rieske (2fe-2S)
L2Z29_13750	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z29_13755	COG0633	Ferredoxin
L2Z29_13755	COG0543	2 iron, 2 sulfur cluster binding
L2Z29_13760	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_13765	COG3135	benzoate transporter
L2Z29_13770	COG2814	Major facilitator Superfamily
L2Z29_13785	COG1643	Atp-dependent helicase
L2Z29_13790	COG0450	alkyl hydroperoxide reductase
L2Z29_13800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z29_13810	COG3634	alkyl hydroperoxide reductase activity
L2Z29_13830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z29_13835	COG0625	glutathione transferase activity
L2Z29_13845	COG2885	chlorophyll binding
L2Z29_13880	COG0542	response to heat
L2Z29_13895	COG1765	OsmC-like protein
L2Z29_13915	COG0667	Aldo Keto reductase
L2Z29_13930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z29_13940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z29_13950	COG0527	aspartate kinase activity
L2Z29_13960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z29_13970	COG3038	cytochrome b561
L2Z29_13975	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z29_13980	COG2252	PERMEase
L2Z29_14000	COG4269	membrane
L2Z29_14015	COG1902	pentaerythritol trinitrate reductase activity
L2Z29_14015	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z29_14025	COG2203	Gaf domain
L2Z29_14025	COG3706	GGDEF domain
L2Z29_14025	COG4251	negative regulation of phosphorylation
L2Z29_14025	COG5001	Diguanylate cyclase
L2Z29_14035	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z29_14055	COG4172	Belongs to the ABC transporter superfamily
L2Z29_14060	COG4239	(ABC) transporter, permease
L2Z29_14065	COG4174	ABC transporter (Permease)
L2Z29_14075	COG1388	LysM domain
L2Z29_14075	COG0741	lytic transglycosylase activity
L2Z29_14075	COG1388	LysM domain
L2Z29_14075	COG0741	lytic transglycosylase activity
L2Z29_14080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z29_14120	COG0583	DNA-binding transcription factor activity
L2Z29_14125	COG1279	arginine transmembrane transporter activity
L2Z29_14145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z29_14150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z29_14155	COG0006	proline dipeptidase activity
L2Z29_14195	COG2194	sulfuric ester hydrolase activity
L2Z29_14240	COG0739	heme binding
L2Z29_14565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z29_14590	COG3384	dioxygenase
L2Z29_14600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z29_14605	COG2878	Part of a membrane complex involved in electron transport
L2Z29_14610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z29_14635	COG0768	penicillin binding
L2Z29_14640	COG0742	ribosomal rna small subunit methyltransferase
L2Z29_14655	COG0830	nickel cation binding
L2Z29_14665	COG0804	urea catabolic process
L2Z29_14705	COG1253	flavin adenine dinucleotide binding
L2Z29_14710	COG2851	Citrate transporter
L2Z29_14755	COG1794	racemase activity, acting on amino acids and derivatives
L2Z29_14765	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z29_14765	COG3008	intermembrane lipid transfer
L2Z29_14770	COG2995	paraquat-inducible protein a
L2Z29_14780	COG2985	domain, Protein
L2Z29_14810	COG0477	Major facilitator Superfamily
L2Z29_14860	COG2186	Transcriptional regulator
L2Z29_14870	COG0786	glutamate:sodium symporter activity
L2Z29_14875	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z29_14900	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z29_15000	COG1610	YqeY-like protein
L2Z29_15005	COG4783	chaperone-mediated protein folding
L2Z29_15030	COG1286	toxin biosynthetic process
L2Z29_15060	COG0778	Nitroreductase
L2Z29_15070	COG0513	Belongs to the DEAD box helicase family
L2Z29_15095	COG2363	Small membrane protein
L2Z29_15125	COG1234	tRNA 3'-trailer cleavage
L2Z29_15130	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z29_15140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z29_15150	COG2819	hydrolase of the alpha beta superfamily
L2Z29_15155	COG1960	acyl-CoA dehydrogenase activity
L2Z29_15160	COG1301	dicarboxylic acid transport
L2Z29_15165	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z29_15170	COG3139	Protein of unknown function (DUF1315)
L2Z29_15175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z29_15180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z29_15190	COG0494	nUDIX hydrolase
L2Z29_15200	COG0642	Histidine kinase
L2Z29_15215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z29_15225	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z29_15240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z29_15245	COG0826	peptidase U32
L2Z29_15250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z29_15260	COG4598	ABC transporter
L2Z29_15265	COG4160	amino acid transport
L2Z29_15270	COG4215	(ABC) transporter
L2Z29_15285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z29_15330	COG1131	(ABC) transporter
L2Z29_15335	COG0842	Transport permease protein
L2Z29_15350	COG0772	Belongs to the SEDS family
L2Z29_15355	COG2951	lytic endotransglycosylase activity
L2Z29_15380	COG2207	Transcriptional regulator
L2Z29_15395	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z29_15400	COG0024	Methionine aminopeptidase
L2Z29_15410	COG2223	nitrite transmembrane transporter activity
L2Z29_15420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z29_15425	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z29_15430	COG1960	acyl-CoA dehydrogenase activity
L2Z29_15445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z29_15450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z29_15455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z29_15475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z29_15480	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z29_15485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z29_15520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z29_15530	COG0174	glutamine synthetase
L2Z29_15545	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z29_15550	COG0308	aminopeptidase N
L2Z29_15580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z29_15590	COG0302	gtp cyclohydrolase
L2Z29_15615	COG3739	integral membrane protein
L2Z29_15630	COG1169	isochorismate synthase
L2Z29_15640	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z29_15645	COG1132	(ABC) transporter
L2Z29_15650	COG1132	(ABC) transporter
L2Z29_15660	COG1535	isochorismatase
L2Z29_15660	COG3433	isochorismatase activity
L2Z29_15665	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z29_15670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z29_15680	COG4774	siderophore transport
L2Z29_15685	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z29_15690	COG4604	ABC transporter, ATP-binding protein
L2Z29_15695	COG4605	iron ion homeostasis
L2Z29_15700	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z29_15705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z29_15720	COG2964	Protein conserved in bacteria
L2Z29_15730	COG1741	Belongs to the pirin family
L2Z29_15750	COG1309	transcriptional regulator
L2Z29_15760	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z29_15765	COG2814	Major facilitator Superfamily
L2Z29_15800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z29_15800	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z29_15805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z29_15815	COG1012	belongs to the aldehyde dehydrogenase family
L2Z29_15825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z29_15830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z29_15835	COG0583	DNA-binding transcription factor activity
L2Z29_15840	COG1113	amino acid transport
L2Z29_15860	COG2508	Transcriptional regulator
L2Z29_15860	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z29_15895	COG2879	small protein
L2Z29_15900	COG1966	Carbon starvation protein
L2Z29_15945	COG1067	ATP-dependent peptidase activity
L2Z29_15950	COG0583	DNA-binding transcription factor activity
L2Z29_15975	COG1686	Belongs to the peptidase S11 family
L2Z29_15980	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z29_16030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z29_16040	COG0573	inorganic phosphate transmembrane transporter activity
L2Z29_16045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z29_16050	COG1113	amino acid transport
L2Z29_16055	COG3961	Belongs to the TPP enzyme family
L2Z29_16060	COG1522	sequence-specific DNA binding
L2Z29_16070	COG0076	glutamate decarboxylase activity
L2Z29_16075	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z29_16085	COG1309	transcriptional regulator
L2Z29_16100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z29_16135	COG0352	thiamine-phosphate diphosphorylase activity
L2Z29_16160	COG0612	Peptidase, M16
L2Z29_16170	COG1823	symporter activity
L2Z29_16175	COG0583	DNA-binding transcription factor activity
L2Z29_16180	COG0477	Major facilitator Superfamily
L2Z29_16205	COG1187	pseudouridine synthase activity
L2Z29_16220	COG1686	Belongs to the peptidase S11 family
L2Z29_16225	COG1252	NADH dehydrogenase
L2Z29_16235	COG0415	Belongs to the DNA photolyase family
L2Z29_16250	COG1215	transferase activity, transferring glycosyl groups
L2Z29_16280	COG2070	2-Nitropropane dioxygenase
L2Z29_16470	COG5410	chromosome segregation
L2Z29_16670	COG0556	nucleotide-excision repair
L2Z29_16690	COG0436	Aminotransferase
L2Z29_16720	COG4221	oxidoreductase activity
L2Z29_16730	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z29_16735	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z29_16745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z29_16760	COG0681	Belongs to the peptidase S26 family
L2Z29_16775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z29_16795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z29_16800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z29_16805	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z29_16815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z29_16820	COG4208	sulfate ABC transporter
L2Z29_16825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z29_16830	COG0583	DNA-binding transcription factor activity
L2Z29_16835	COG4625	pathogenesis
L2Z29_16850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z29_16865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z29_16875	COG1051	belongs to the nudix hydrolase family
L2Z29_16875	COG1056	cytidyltransferase-related domain
L2Z29_16880	COG1024	Enoyl-CoA hydratase
L2Z29_16890	COG2814	Major facilitator Superfamily
L2Z29_16895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z29_16895	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z29_16915	COG1473	amidohydrolase
L2Z29_16920	COG0824	Thioesterase
L2Z29_16940	COG0823	Involved in the tonB-independent uptake of proteins
L2Z29_16960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z29_16995	COG0628	permease
L2Z29_17005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z29_17010	COG0596	Alpha beta hydrolase
L2Z29_17015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z29_17015	COG0616	signal peptide processing
L2Z29_17025	COG2333	competence protein COMEC
L2Z29_17025	COG0658	competence protein
L2Z29_17030	COG1136	(ABC) transporter
L2Z29_17035	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z29_17070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z29_17090	COG0463	Glycosyl transferase, family 2
L2Z29_17120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z29_17125	COG1280	lysine exporter protein (LysE YggA)
L2Z29_17135	COG0019	diaminopimelate decarboxylase activity
L2Z29_17145	COG1113	amino acid transport
L2Z29_17160	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z29_17170	COG3339	Conserved Protein
L2Z29_17175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z29_17180	COG0243	molybdopterin cofactor binding
L2Z29_17185	COG1929	Belongs to the glycerate kinase type-1 family
L2Z29_17200	COG0778	Nitroreductase
L2Z29_17230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z29_17245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z29_17265	COG0741	lytic transglycosylase activity
L2Z29_17285	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z29_17290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z29_17315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z29_17320	COG1597	lipid kinase activity
L2Z29_17335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z29_17340	COG0477	Major facilitator Superfamily
L2Z29_17390	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z29_17395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z29_17420	COG0505	Belongs to the CarA family
L2Z29_17440	COG0589	response to stress
L2Z29_17455	COG2843	Capsule synthesis protein
L2Z29_17475	COG2321	neutral zinc metallopeptidase
L2Z29_17480	COG2354	Protein conserved in bacteria
L2Z29_17500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z29_17525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z29_17530	COG1053	succinate dehydrogenase
L2Z29_17535	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z29_17540	COG2009	succinate dehydrogenase
L2Z29_17580	COG2921	Belongs to the UPF0250 family
L2Z29_17585	COG0321	lipoyl(octanoyl) transferase activity
L2Z29_17600	COG0531	amino acid
L2Z29_17610	COG1733	regulation of RNA biosynthetic process
L2Z29_17615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z29_17620	COG1648	precorrin-2 dehydrogenase activity
L2Z29_17620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z29_17635	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z29_17665	COG0671	phosphoesterase, PA-phosphatase related
L2Z29_17670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z29_17680	COG1538	Outer membrane efflux protein
L2Z29_17685	COG0393	Putative heavy-metal-binding
L2Z29_17690	COG0393	Putative heavy-metal-binding
L2Z29_17700	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z29_17710	COG0525	valine-tRNA ligase activity
L2Z29_17730	COG0583	DNA-binding transcription factor activity
L2Z29_17735	COG0004	ammonium transporteR
L2Z29_17745	COG0642	Histidine kinase
L2Z29_17750	COG0745	RESPONSE REGULATOR receiver
L2Z29_17755	COG2194	sulfuric ester hydrolase activity
L2Z29_17775	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z29_17790	COG2315	Protein conserved in bacteria
L2Z29_17795	COG0142	geranyltranstransferase activity
L2Z29_17800	COG2828	Protein conserved in bacteria
L2Z29_17805	COG1113	amino acid transport
L2Z29_17825	COG2207	Transcriptional regulator
L2Z29_17850	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z29_17860	COG0560	Phosphoserine phosphatase
L2Z29_17870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z29_17880	COG1530	ribonuclease E activity
L2Z29_17885	COG0424	maF-like protein
L2Z29_17890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z29_17895	COG1792	Involved in formation and maintenance of cell shape
L2Z29_17900	COG1077	Cell shape determining protein MreB Mrl
L2Z29_17905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z29_17915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z29_17945	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z29_17950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z29_17955	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z29_17960	COG1115	amino acid carrier protein
L2Z29_17980	COG2814	Major facilitator Superfamily
L2Z29_17985	COG1289	transmembrane transporter activity
L2Z29_17995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z29_18035	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z29_18040	COG2832	Protein of unknown function (DUF454)
L2Z29_18050	COG5510	response to toxic substance
L2Z29_18070	COG0840	transmembrane signaling receptor activity
L2Z29_18110	COG3422	double-strand break repair
L2Z29_18115	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z29_18120	COG3189	MarR family transcriptional regulator
L2Z29_18130	COG0354	folic acid binding
L2Z29_18135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z29_18145	COG0679	Auxin Efflux Carrier
L2Z29_18150	COG1902	pentaerythritol trinitrate reductase activity
L2Z29_18170	COG2094	Belongs to the DNA glycosylase MPG family
L2Z29_18195	COG1217	gtp-binding protein TYPA
L2Z29_18200	COG2233	PERMEase
L2Z29_18210	COG0833	amino acid
L2Z29_18215	COG1690	Belongs to the RtcB family
L2Z29_18225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z29_18225	COG2885	chlorophyll binding
L2Z29_18235	COG0183	Belongs to the thiolase family
L2Z29_18255	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z29_18275	COG2207	Transcriptional regulator
L2Z29_18280	COG0183	Belongs to the thiolase family
L2Z29_18310	COG1272	protein, Hemolysin III
L2Z29_18315	COG0477	Major facilitator Superfamily
L2Z29_18330	COG0450	alkyl hydroperoxide reductase
L2Z29_18350	COG0285	dihydrofolate synthase activity
L2Z29_18400	COG2096	Adenosyltransferase
L2Z29_18420	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z29_18425	COG0745	RESPONSE REGULATOR receiver
L2Z29_18430	COG2205	protein histidine kinase activity
L2Z29_18440	COG1960	acyl-CoA dehydrogenase activity
L2Z29_18445	COG1960	acyl-CoA dehydrogenase activity
L2Z29_18450	COG0583	DNA-binding transcription factor activity
L2Z29_18455	COG0625	glutathione transferase activity
L2Z29_18520	COG0438	transferase activity, transferring glycosyl groups
L2Z29_18525	COG0463	Glycosyl transferase, family 2
L2Z29_18530	COG0726	polysaccharide deacetylase
L2Z29_18550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z29_18555	COG2205	protein histidine kinase activity
L2Z29_18605	COG1862	Preprotein translocase
L2Z29_18615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z29_18620	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z29_18630	COG3781	membrane
L2Z29_18635	COG0613	PHP domain protein
L2Z29_18645	COG2350	Protein conserved in bacteria