locus-tag	class	description
L2Z38_00040	COG0733	neurotransmitter:sodium symporter activity
L2Z38_00075	COG0583	DNA-binding transcription factor activity
L2Z38_00080	COG2233	PERMEase
L2Z38_00095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z38_00130	COG2814	Major facilitator Superfamily
L2Z38_00135	COG0656	L-ascorbic acid biosynthetic process
L2Z38_00140	COG0583	DNA-binding transcription factor activity
L2Z38_00155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z38_00160	COG1064	alcohol dehydrogenase
L2Z38_00165	COG2818	Glycosylase
L2Z38_00180	COG1194	a g-specific adenine glycosylase
L2Z38_00200	COG2983	Belongs to the UPF0260 family
L2Z38_00205	COG2133	pyrroloquinoline quinone binding
L2Z38_00210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z38_00215	COG2116	formate transmembrane transporter activity
L2Z38_00235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z38_00240	COG1335	isochorismatase
L2Z38_00245	COG0385	Bile acid
L2Z38_00250	COG0534	Mate efflux family protein
L2Z38_00255	COG1683	Conserved Protein
L2Z38_00275	COG0625	glutathione transferase activity
L2Z38_00285	COG1113	amino acid transport
L2Z38_00295	COG0523	cobalamin synthesis protein
L2Z38_00305	COG2188	Transcriptional regulator
L2Z38_00335	COG0010	Belongs to the arginase family
L2Z38_00350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z38_00380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z38_00390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z38_00395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z38_00480	COG0534	Mate efflux family protein
L2Z38_00485	COG0436	Aminotransferase
L2Z38_00490	COG2733	membrane
L2Z38_00505	COG2918	glutathione biosynthetic process
L2Z38_00560	COG3150	esterase
L2Z38_00570	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z38_00580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z38_00590	COG2233	PERMEase
L2Z38_00595	COG2351	hydroxyisourate hydrolase activity
L2Z38_00630	COG3706	GGDEF domain
L2Z38_00645	COG1393	Belongs to the ArsC family
L2Z38_00650	COG0708	Exodeoxyribonuclease III
L2Z38_00670	COG0189	ligase activity
L2Z38_00690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z38_00700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z38_00715	COG4942	peptidase
L2Z38_00725	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z38_00735	COG2119	membrane
L2Z38_00740	COG4774	siderophore transport
L2Z38_00745	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z38_00745	COG0426	domain, Protein
L2Z38_00770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z38_00790	COG1902	pentaerythritol trinitrate reductase activity
L2Z38_00795	COG1519	Transferase
L2Z38_00800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z38_00805	COG0668	transmembrane transport
L2Z38_00815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z38_00820	COG1335	isochorismatase
L2Z38_00825	COG1522	sequence-specific DNA binding
L2Z38_00850	COG0784	Response regulator, receiver
L2Z38_00850	COG2198	Histidine kinase
L2Z38_00850	COG2205	protein histidine kinase activity
L2Z38_00855	COG3162	membrane
L2Z38_00860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z38_00870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z38_00885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z38_00890	COG1309	transcriptional regulator
L2Z38_00910	COG0351	phosphomethylpyrimidine kinase
L2Z38_00910	COG0352	thiamine-phosphate diphosphorylase activity
L2Z38_00910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z38_00920	COG2814	Major facilitator Superfamily
L2Z38_00935	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z38_00945	COG1113	amino acid transport
L2Z38_00955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z38_00960	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_00970	COG1335	isochorismatase
L2Z38_01000	COG2814	Major facilitator Superfamily
L2Z38_01005	COG0583	DNA-binding transcription factor activity
L2Z38_01025	COG0667	Aldo Keto reductase
L2Z38_01045	COG1733	regulation of RNA biosynthetic process
L2Z38_01060	COG1733	regulation of RNA biosynthetic process
L2Z38_01065	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z38_01075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2Z38_01135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z38_01175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z38_01205	COG0427	acetyl-CoA hydrolase
L2Z38_01235	COG0659	secondary active sulfate transmembrane transporter activity
L2Z38_01240	COG4221	oxidoreductase activity
L2Z38_01245	COG2873	o-acetylhomoserine
L2Z38_01250	COG0488	(ABC) transporter
L2Z38_01315	COG0833	amino acid
L2Z38_01360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z38_01365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z38_01380	COG2226	methyltransferase
L2Z38_01430	COG0069	glutamate synthase activity
L2Z38_01430	COG0067	glutamate synthase
L2Z38_01430	COG0070	glutamate synthase
L2Z38_01435	COG0493	'glutamate synthase
L2Z38_01445	COG1704	LemA family
L2Z38_01450	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z38_01465	COG3307	-O-antigen
L2Z38_01485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z38_01500	COG0194	GDP metabolic process
L2Z38_01550	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z38_01570	COG5380	lipid catabolic process
L2Z38_01575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z38_01600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z38_01605	COG0277	FAD linked oxidase domain protein
L2Z38_01615	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z38_01620	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z38_01635	COG1289	transmembrane transporter activity
L2Z38_01645	COG0628	permease
L2Z38_01650	COG1192	Involved in chromosome partitioning
L2Z38_01680	COG0833	amino acid
L2Z38_01685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z38_01690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z38_01700	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_01740	COG0583	DNA-binding transcription factor activity
L2Z38_01790	COG0517	IMP dehydrogenase activity
L2Z38_01795	COG1983	PspC domain protein
L2Z38_01805	COG1960	acyl-CoA dehydrogenase activity
L2Z38_01820	COG0408	coproporphyrinogen oxidase activity
L2Z38_01840	COG0513	Belongs to the DEAD box helicase family
L2Z38_01850	COG1127	ABC transporter
L2Z38_01855	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z38_01865	COG2854	intermembrane phospholipid transfer
L2Z38_01875	COG0598	Magnesium transport protein CorA
L2Z38_01885	COG0494	nUDIX hydrolase
L2Z38_01890	COG1040	competence protein
L2Z38_01895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z38_01915	COG1946	Acyl-CoA thioesterase
L2Z38_01920	COG1301	dicarboxylic acid transport
L2Z38_01935	COG1959	2 iron, 2 sulfur cluster binding
L2Z38_01940	COG1017	nitric oxide dioxygenase activity
L2Z38_01940	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z38_01945	COG0433	COG0433 Predicted ATPase
L2Z38_01950	COG0626	cystathionine gamma-synthase activity
L2Z38_02105	COG1960	acyl-CoA dehydrogenase activity
L2Z38_02110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z38_02140	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z38_02145	COG0339	signal peptide processing
L2Z38_02150	COG0557	exoribonuclease II activity
L2Z38_02195	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z38_02200	COG2169	Transcriptional regulator
L2Z38_02205	COG0697	spore germination
L2Z38_02210	COG1295	ribonuclease BN
L2Z38_02245	COG1702	phosphate starvation-inducible protein PhoH
L2Z38_02255	COG0739	heme binding
L2Z38_02255	COG1196	nuclear chromosome segregation
L2Z38_02255	COG0741	lytic transglycosylase activity
L2Z38_02285	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z38_02290	COG1183	phosphatidylcholine synthase activity
L2Z38_02335	COG1960	acyl-CoA dehydrogenase activity
L2Z38_02340	COG1309	transcriptional regulator
L2Z38_02355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z38_02360	COG1960	acyl-CoA dehydrogenase activity
L2Z38_02380	COG2969	positive regulation of protein catabolic process
L2Z38_02390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z38_02405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z38_02410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z38_02430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z38_02440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z38_02445	COG1408	metallophosphoesterase
L2Z38_02455	COG2199	diguanylate cyclase activity
L2Z38_02515	COG1607	acyl-coa hydrolase
L2Z38_02545	COG2350	Protein conserved in bacteria
L2Z38_02555	COG0613	PHP domain protein
L2Z38_02560	COG3781	membrane
L2Z38_02570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z38_02585	COG1862	Preprotein translocase
L2Z38_02630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z38_02635	COG0629	single-stranded DNA binding
L2Z38_02680	COG3646	Phage regulatory protein
L2Z38_02690	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2Z38_02820	COG4695	Portal protein
L2Z38_02825	COG2205	protein histidine kinase activity
L2Z38_02830	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z38_02850	COG0726	polysaccharide deacetylase
L2Z38_02855	COG0463	Glycosyl transferase, family 2
L2Z38_02860	COG0438	transferase activity, transferring glycosyl groups
L2Z38_02935	COG1960	acyl-CoA dehydrogenase activity
L2Z38_02940	COG1960	acyl-CoA dehydrogenase activity
L2Z38_02950	COG2205	protein histidine kinase activity
L2Z38_02955	COG0745	RESPONSE REGULATOR receiver
L2Z38_02960	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z38_02980	COG2096	Adenosyltransferase
L2Z38_03030	COG0285	dihydrofolate synthase activity
L2Z38_03050	COG0450	alkyl hydroperoxide reductase
L2Z38_03065	COG0477	Major facilitator Superfamily
L2Z38_03070	COG1272	protein, Hemolysin III
L2Z38_03080	COG2153	protein acetylation
L2Z38_03100	COG0183	Belongs to the thiolase family
L2Z38_03105	COG2207	Transcriptional regulator
L2Z38_03125	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z38_03145	COG0183	Belongs to the thiolase family
L2Z38_03155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z38_03155	COG2885	chlorophyll binding
L2Z38_03165	COG1690	Belongs to the RtcB family
L2Z38_03170	COG0833	amino acid
L2Z38_03180	COG2233	PERMEase
L2Z38_03185	COG1217	gtp-binding protein TYPA
L2Z38_03210	COG2094	Belongs to the DNA glycosylase MPG family
L2Z38_03215	COG4772	TonB-dependent receptor
L2Z38_03220	COG1902	pentaerythritol trinitrate reductase activity
L2Z38_03235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z38_03240	COG0354	folic acid binding
L2Z38_03250	COG3189	MarR family transcriptional regulator
L2Z38_03255	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z38_03260	COG3422	double-strand break repair
L2Z38_03300	COG0840	transmembrane signaling receptor activity
L2Z38_03315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z38_03330	COG5510	response to toxic substance
L2Z38_03340	COG2832	Protein of unknown function (DUF454)
L2Z38_03345	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z38_03385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z38_03395	COG1289	transmembrane transporter activity
L2Z38_03400	COG2814	Major facilitator Superfamily
L2Z38_03420	COG1115	amino acid carrier protein
L2Z38_03425	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z38_03430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z38_03435	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z38_03460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z38_03470	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z38_03475	COG1077	Cell shape determining protein MreB Mrl
L2Z38_03480	COG1792	Involved in formation and maintenance of cell shape
L2Z38_03485	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z38_03490	COG0424	maF-like protein
L2Z38_03495	COG1530	ribonuclease E activity
L2Z38_03505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z38_03515	COG0560	Phosphoserine phosphatase
L2Z38_03525	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z38_03550	COG2207	Transcriptional regulator
L2Z38_03570	COG1113	amino acid transport
L2Z38_03575	COG2828	Protein conserved in bacteria
L2Z38_03580	COG0142	geranyltranstransferase activity
L2Z38_03585	COG2315	Protein conserved in bacteria
L2Z38_03600	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z38_03615	COG3676	manually curated
L2Z38_03630	COG2194	sulfuric ester hydrolase activity
L2Z38_03635	COG0745	RESPONSE REGULATOR receiver
L2Z38_03640	COG0642	Histidine kinase
L2Z38_03650	COG0004	ammonium transporteR
L2Z38_03655	COG0583	DNA-binding transcription factor activity
L2Z38_03675	COG0525	valine-tRNA ligase activity
L2Z38_03685	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_03695	COG0393	Putative heavy-metal-binding
L2Z38_03700	COG0393	Putative heavy-metal-binding
L2Z38_03705	COG1538	Outer membrane efflux protein
L2Z38_03715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z38_03720	COG0671	phosphoesterase, PA-phosphatase related
L2Z38_03725	COG3676	manually curated
L2Z38_03755	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z38_03770	COG1648	precorrin-2 dehydrogenase activity
L2Z38_03770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z38_03775	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z38_03780	COG1733	regulation of RNA biosynthetic process
L2Z38_03790	COG0531	amino acid
L2Z38_03805	COG0321	lipoyl(octanoyl) transferase activity
L2Z38_03810	COG2921	Belongs to the UPF0250 family
L2Z38_03845	COG2009	succinate dehydrogenase
L2Z38_03850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z38_03855	COG1053	succinate dehydrogenase
L2Z38_03860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z38_03885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z38_03915	COG2354	Protein conserved in bacteria
L2Z38_03920	COG2321	neutral zinc metallopeptidase
L2Z38_03950	COG2843	Capsule synthesis protein
L2Z38_03965	COG0589	response to stress
L2Z38_03985	COG0505	Belongs to the CarA family
L2Z38_04010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z38_04015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z38_04065	COG0477	Major facilitator Superfamily
L2Z38_04070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z38_04085	COG1597	lipid kinase activity
L2Z38_04090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z38_04115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z38_04120	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z38_04140	COG0741	lytic transglycosylase activity
L2Z38_04160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z38_04175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z38_04210	COG0778	Nitroreductase
L2Z38_04225	COG1929	Belongs to the glycerate kinase type-1 family
L2Z38_04230	COG0243	molybdopterin cofactor binding
L2Z38_04235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z38_04240	COG3339	Conserved Protein
L2Z38_04250	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z38_04265	COG1113	amino acid transport
L2Z38_04275	COG0019	diaminopimelate decarboxylase activity
L2Z38_04285	COG1280	lysine exporter protein (LysE YggA)
L2Z38_04290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z38_04320	COG0463	Glycosyl transferase, family 2
L2Z38_04340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z38_04375	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z38_04380	COG1136	(ABC) transporter
L2Z38_04385	COG0658	competence protein
L2Z38_04385	COG2333	competence protein COMEC
L2Z38_04395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z38_04395	COG0616	signal peptide processing
L2Z38_04400	COG0596	Alpha beta hydrolase
L2Z38_04405	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z38_04415	COG0628	permease
L2Z38_04450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z38_04470	COG0823	Involved in the tonB-independent uptake of proteins
L2Z38_04490	COG0824	Thioesterase
L2Z38_04495	COG1473	amidohydrolase
L2Z38_04515	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z38_04515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z38_04520	COG2814	Major facilitator Superfamily
L2Z38_04530	COG1024	Enoyl-CoA hydratase
L2Z38_04535	COG1051	belongs to the nudix hydrolase family
L2Z38_04535	COG1056	cytidyltransferase-related domain
L2Z38_04545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z38_04560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z38_04575	COG4625	pathogenesis
L2Z38_04580	COG0583	DNA-binding transcription factor activity
L2Z38_04585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z38_04590	COG4208	sulfate ABC transporter
L2Z38_04595	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z38_04605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z38_04610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z38_04615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z38_04635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z38_04650	COG0681	Belongs to the peptidase S26 family
L2Z38_04665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z38_04675	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z38_04680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z38_04690	COG4221	oxidoreductase activity
L2Z38_04720	COG0436	Aminotransferase
L2Z38_04745	COG0556	nucleotide-excision repair
L2Z38_04800	COG2070	2-Nitropropane dioxygenase
L2Z38_04830	COG1215	transferase activity, transferring glycosyl groups
L2Z38_04845	COG0415	Belongs to the DNA photolyase family
L2Z38_04855	COG1252	NADH dehydrogenase
L2Z38_04860	COG1686	Belongs to the peptidase S11 family
L2Z38_04875	COG1187	pseudouridine synthase activity
L2Z38_04895	COG0477	Major facilitator Superfamily
L2Z38_04900	COG0583	DNA-binding transcription factor activity
L2Z38_04905	COG1823	symporter activity
L2Z38_04915	COG0612	Peptidase, M16
L2Z38_04945	COG1203	CRISPR-associated helicase, Cas3
L2Z38_04970	COG0352	thiamine-phosphate diphosphorylase activity
L2Z38_05005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z38_05020	COG1309	transcriptional regulator
L2Z38_05030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z38_05035	COG0076	glutamate decarboxylase activity
L2Z38_05045	COG1522	sequence-specific DNA binding
L2Z38_05050	COG3961	Belongs to the TPP enzyme family
L2Z38_05055	COG1113	amino acid transport
L2Z38_05060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z38_05065	COG0573	inorganic phosphate transmembrane transporter activity
L2Z38_05075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z38_05080	COG0616	signal peptide processing
L2Z38_05115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z38_05120	COG1686	Belongs to the peptidase S11 family
L2Z38_05145	COG0583	DNA-binding transcription factor activity
L2Z38_05150	COG1067	ATP-dependent peptidase activity
L2Z38_05175	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L2Z38_05195	COG1966	Carbon starvation protein
L2Z38_05200	COG2879	small protein
L2Z38_05210	COG0583	DNA-binding transcription factor activity
L2Z38_05215	COG0006	proline dipeptidase activity
L2Z38_05220	COG0006	proline dipeptidase activity
L2Z38_05225	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z38_05230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z38_05240	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_05250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z38_05255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z38_05255	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z38_05315	COG1741	Belongs to the pirin family
L2Z38_05325	COG2964	Protein conserved in bacteria
L2Z38_05340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z38_05345	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z38_05350	COG4605	iron ion homeostasis
L2Z38_05355	COG4604	ABC transporter, ATP-binding protein
L2Z38_05360	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z38_05365	COG4774	siderophore transport
L2Z38_05375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z38_05380	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z38_05385	COG1535	isochorismatase
L2Z38_05385	COG3433	isochorismatase activity
L2Z38_05400	COG1132	(ABC) transporter
L2Z38_05405	COG1132	(ABC) transporter
L2Z38_05410	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z38_05420	COG1169	isochorismate synthase
L2Z38_05435	COG3739	integral membrane protein
L2Z38_05455	COG3676	manually curated
L2Z38_05470	COG0302	gtp cyclohydrolase
L2Z38_05480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z38_05515	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z38_05530	COG0174	glutamine synthetase
L2Z38_05540	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z38_05575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z38_05580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z38_05585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z38_05615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z38_05620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z38_05625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z38_05640	COG1960	acyl-CoA dehydrogenase activity
L2Z38_05645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z38_05650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z38_05660	COG2223	nitrite transmembrane transporter activity
L2Z38_05670	COG0024	Methionine aminopeptidase
L2Z38_05675	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z38_05690	COG2207	Transcriptional regulator
L2Z38_05715	COG2951	lytic endotransglycosylase activity
L2Z38_05720	COG0772	Belongs to the SEDS family
L2Z38_05735	COG0842	Transport permease protein
L2Z38_05740	COG1131	(ABC) transporter
L2Z38_05745	COG0582	viral genome integration into host DNA
L2Z38_05785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z38_05850	COG0305	Participates in initiation and elongation during chromosome replication
L2Z38_05945	COG5410	chromosome segregation
L2Z38_06065	COG0739	heme binding
L2Z38_06175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z38_06190	COG4215	(ABC) transporter
L2Z38_06195	COG4160	amino acid transport
L2Z38_06210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z38_06215	COG0826	peptidase U32
L2Z38_06220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z38_06235	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z38_06245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z38_06260	COG0642	Histidine kinase
L2Z38_06270	COG0494	nUDIX hydrolase
L2Z38_06280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z38_06285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z38_06290	COG3139	Protein of unknown function (DUF1315)
L2Z38_06295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z38_06300	COG1301	dicarboxylic acid transport
L2Z38_06305	COG1960	acyl-CoA dehydrogenase activity
L2Z38_06310	COG2819	hydrolase of the alpha beta superfamily
L2Z38_06320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z38_06330	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z38_06335	COG1234	tRNA 3'-trailer cleavage
L2Z38_06360	COG2363	Small membrane protein
L2Z38_06385	COG0513	Belongs to the DEAD box helicase family
L2Z38_06395	COG0778	Nitroreductase
L2Z38_06425	COG1286	toxin biosynthetic process
L2Z38_06450	COG4783	chaperone-mediated protein folding
L2Z38_06455	COG1610	YqeY-like protein
L2Z38_06555	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z38_06580	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z38_06585	COG0786	glutamate:sodium symporter activity
L2Z38_06595	COG0583	DNA-binding transcription factor activity
L2Z38_06605	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_06620	COG2186	Transcriptional regulator
L2Z38_06680	COG0477	Major facilitator Superfamily
L2Z38_06705	COG2995	paraquat-inducible protein a
L2Z38_06710	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z38_06710	COG3008	intermembrane lipid transfer
L2Z38_06720	COG2351	hydroxyisourate hydrolase activity
L2Z38_06760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2Z38_06770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2Z38_06775	COG0642	Histidine kinase
L2Z38_06780	COG0745	RESPONSE REGULATOR receiver
L2Z38_06800	COG1794	racemase activity, acting on amino acids and derivatives
L2Z38_06830	COG1301	dicarboxylic acid transport
L2Z38_06835	COG3676	manually curated
L2Z38_06845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z38_06850	COG2011	ABC-type metal ion transport system permease component
L2Z38_06855	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z38_06860	COG1464	Belongs to the NlpA lipoprotein family
L2Z38_06865	COG0151	Belongs to the GarS family
L2Z38_06870	COG0138	bifunctional purine biosynthesis protein purh
L2Z38_06875	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z38_06905	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z38_06915	COG1305	Transglutaminase-like
L2Z38_06925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z38_06930	COG0305	Participates in initiation and elongation during chromosome replication
L2Z38_06955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z38_06965	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z38_06970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z38_06995	COG0726	polysaccharide deacetylase
L2Z38_06995	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z38_07000	COG1215	transferase activity, transferring glycosyl groups
L2Z38_07005	COG3658	cytochrome
L2Z38_07015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z38_07030	COG0583	DNA-binding transcription factor activity
L2Z38_07050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z38_07055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z38_07070	COG1960	acyl-CoA dehydrogenase activity
L2Z38_07075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z38_07080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z38_07105	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z38_07110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z38_07120	COG2205	protein histidine kinase activity
L2Z38_07125	COG0745	RESPONSE REGULATOR receiver
L2Z38_07130	COG0174	glutamine synthetase
L2Z38_07150	COG0729	surface antigen
L2Z38_07175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z38_07180	COG2814	Major facilitator Superfamily
L2Z38_07195	COG0583	DNA-binding transcription factor activity
L2Z38_07210	COG1187	pseudouridine synthase activity
L2Z38_07230	COG0802	atpase or kinase
L2Z38_07235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z38_07245	COG1923	regulation of RNA biosynthetic process
L2Z38_07250	COG0697	spore germination
L2Z38_07275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z38_07280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z38_07280	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z38_07285	COG4302	ethanolamine ammonia-lyase activity
L2Z38_07290	COG4303	Ethanolamine ammonia lyase large subunit
L2Z38_07295	COG0531	amino acid
L2Z38_07315	COG1454	alcohol dehydrogenase
L2Z38_07320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z38_07345	COG0308	aminopeptidase N
L2Z38_07385	COG1605	Chorismate mutase
L2Z38_07400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L2Z38_07415	COG1309	transcriptional regulator
L2Z38_07425	COG0668	transmembrane transport
L2Z38_07455	COG4773	Receptor
L2Z38_07475	COG0488	(ABC) transporter
L2Z38_07480	COG0589	response to stress
L2Z38_07500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z38_07510	COG3135	benzoate transporter
L2Z38_07515	COG1522	sequence-specific DNA binding
L2Z38_07525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z38_07530	COG0583	DNA-binding transcription factor activity
L2Z38_07540	COG0183	Belongs to the thiolase family
L2Z38_07550	COG2030	dehydratase
L2Z38_07555	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z38_07570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z38_07580	COG0824	Thioesterase
L2Z38_07585	COG1454	alcohol dehydrogenase
L2Z38_07595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z38_07615	COG0069	glutamate synthase activity
L2Z38_07635	COG2814	Major facilitator Superfamily
L2Z38_07650	COG0511	ligase activity, forming carbon-carbon bonds
L2Z38_07670	COG1116	anion transmembrane transporter activity
L2Z38_07670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z38_07675	COG0745	RESPONSE REGULATOR receiver
L2Z38_07685	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z38_07685	COG2146	nitrite reductase [NAD(P)H] activity
L2Z38_07690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z38_07695	COG0243	molybdopterin cofactor binding
L2Z38_07705	COG0243	molybdopterin cofactor binding
L2Z38_07710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z38_07725	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z38_07725	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z38_07730	COG0303	'Molybdopterin
L2Z38_07750	COG0697	spore germination
L2Z38_07770	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z38_07775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z38_07830	COG2204	response regulator
L2Z38_07835	COG3852	Histidine kinase
L2Z38_07860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z38_07865	COG0575	Belongs to the CDS family
L2Z38_07900	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z38_07915	COG2137	regulation of response to DNA damage stimulus
L2Z38_07925	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z38_07930	COG1011	Hydrolase
L2Z38_07955	COG1522	sequence-specific DNA binding
L2Z38_07965	COG1113	amino acid transport
L2Z38_07985	COG0659	secondary active sulfate transmembrane transporter activity
L2Z38_07990	COG2135	peptidase activity
L2Z38_08025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z38_08025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z38_08025	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z38_08030	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z38_08035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z38_08035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z38_08065	COG0024	Methionine aminopeptidase
L2Z38_08070	COG0583	DNA-binding transcription factor activity
L2Z38_08080	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z38_08085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z38_08090	COG0516	GMP reductase activity
L2Z38_08090	COG0517	IMP dehydrogenase activity
L2Z38_08115	COG0552	protein localization to endoplasmic reticulum
L2Z38_08125	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z38_08135	COG4890	Cyd operon protein YbgT
L2Z38_08140	COG1294	oxidase, subunit
L2Z38_08155	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z38_08165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z38_08170	COG4774	siderophore transport
L2Z38_08185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z38_08190	COG0569	domain protein
L2Z38_08195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z38_08225	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z38_08230	COG0542	response to heat
L2Z38_08255	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z38_08255	COG1902	pentaerythritol trinitrate reductase activity
L2Z38_08300	COG2323	membrane
L2Z38_08305	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z38_08315	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z38_08320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z38_08325	COG0183	Belongs to the thiolase family
L2Z38_08330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z38_08335	COG0596	Alpha beta hydrolase
L2Z38_08340	COG2271	Major facilitator Superfamily
L2Z38_08345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z38_08350	COG3485	protocatechuate 3,4-dioxygenase
L2Z38_08355	COG3485	protocatechuate 3,4-dioxygenase
L2Z38_08360	COG0710	3-dehydroquinate dehydratase activity
L2Z38_08365	COG3420	alginic acid biosynthetic process
L2Z38_08370	COG3659	wide pore channel activity
L2Z38_08375	COG4993	Dehydrogenase
L2Z38_08385	COG2391	methyltransferase activity
L2Z38_08400	COG1414	Transcriptional regulator
L2Z38_08405	COG0583	DNA-binding transcription factor activity
L2Z38_08410	COG1960	acyl-CoA dehydrogenase activity
L2Z38_08435	COG2814	Major facilitator Superfamily
L2Z38_08445	COG0154	amidase activity
L2Z38_08465	COG4638	Rieske (2fe-2S)
L2Z38_08475	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_08485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z38_08495	COG3733	amine oxidase
L2Z38_08505	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_08515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z38_08520	COG0183	Belongs to the thiolase family
L2Z38_08525	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z38_08530	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z38_08540	COG4829	muconolactone delta-isomerase
L2Z38_08545	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z38_08550	COG0583	DNA-binding transcription factor activity
L2Z38_08560	COG2186	Transcriptional regulator
L2Z38_08580	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_08595	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z38_08595	COG1902	pentaerythritol trinitrate reductase activity
L2Z38_08635	COG1309	transcriptional regulator
L2Z38_08645	COG4221	oxidoreductase activity
L2Z38_08650	COG4689	acetoacetate decarboxylase
L2Z38_08660	COG1902	pentaerythritol trinitrate reductase activity
L2Z38_08680	COG1335	isochorismatase
L2Z38_08685	COG0583	DNA-binding transcription factor activity
L2Z38_08695	COG0475	glutathione-regulated potassium exporter activity
L2Z38_08695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z38_08705	COG1473	amidohydrolase
L2Z38_08765	COG2188	Transcriptional regulator
L2Z38_08780	COG0583	DNA-binding transcription factor activity
L2Z38_08795	COG1566	PFAM secretion protein HlyD family protein
L2Z38_08810	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_08815	COG0129	dihydroxy-acid dehydratase activity
L2Z38_08825	COG0583	DNA-binding transcription factor activity
L2Z38_08830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z38_08840	COG2084	Dehydrogenase
L2Z38_08855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z38_08915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z38_08930	COG0556	nucleotide-excision repair
L2Z38_08935	COG3676	manually curated
L2Z38_08970	COG1073	alpha beta
L2Z38_08980	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_08995	COG2207	Transcriptional regulator
L2Z38_09005	COG2205	protein histidine kinase activity
L2Z38_09010	COG0745	RESPONSE REGULATOR receiver
L2Z38_09015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z38_09020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z38_09025	COG1538	Outer membrane efflux protein
L2Z38_09035	COG2072	flavoprotein involved in K transport
L2Z38_09045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z38_09085	COG3539	Fimbrial protein
L2Z38_09110	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z38_09120	COG0753	catalase activity
L2Z38_09135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z38_09195	COG3433	isochorismatase activity
L2Z38_09195	COG1535	isochorismatase
L2Z38_09200	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_09205	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z38_09210	COG4149	molybdate abc transporter
L2Z38_09215	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z38_09225	COG4638	Rieske (2fe-2S)
L2Z38_09230	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z38_09235	COG0543	2 iron, 2 sulfur cluster binding
L2Z38_09235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z38_09250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z38_09295	COG0589	response to stress
L2Z38_09300	COG0659	secondary active sulfate transmembrane transporter activity
L2Z38_09310	COG1002	Type II restriction enzyme, methylase subunits
L2Z38_09315	COG1061	Type III restriction enzyme res subunit
L2Z38_09345	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_09360	COG2207	Transcriptional regulator
L2Z38_09365	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_09370	COG2610	gluconate transmembrane transporter activity
L2Z38_09380	COG0583	DNA-binding transcription factor activity
L2Z38_09395	COG2031	fatty acid transporter
L2Z38_09400	COG0183	Belongs to the thiolase family
L2Z38_09405	COG0583	DNA-binding transcription factor activity
L2Z38_09425	COG1027	Aspartate ammonia-lyase
L2Z38_09435	COG0477	Major facilitator Superfamily
L2Z38_09455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z38_09460	COG4521	taurine ABC transporter
L2Z38_09475	COG2188	Transcriptional regulator
L2Z38_09485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z38_09490	COG1733	regulation of RNA biosynthetic process
L2Z38_09495	COG2207	Transcriptional regulator
L2Z38_09495	COG3708	Transcriptional regulator
L2Z38_09510	COG0730	response to heat
L2Z38_09525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z38_09525	COG3453	Protein conserved in bacteria
L2Z38_09535	COG3781	membrane
L2Z38_09540	COG1063	alcohol dehydrogenase
L2Z38_09550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z38_09555	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z38_09560	COG0022	dehydrogenase e1 component
L2Z38_09565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z38_09570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z38_09585	COG3706	GGDEF domain
L2Z38_09600	COG0133	tryptophan synthase activity
L2Z38_09610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z38_09645	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z38_09670	COG2226	methyltransferase
L2Z38_09725	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z38_09730	COG4773	Receptor
L2Z38_09750	COG0730	response to heat
L2Z38_09755	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z38_09770	COG0406	alpha-ribazole phosphatase activity
L2Z38_09775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z38_09790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z38_09820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z38_09830	COG4264	IucA IucC family
L2Z38_09835	COG4264	IucA IucC family
L2Z38_09840	COG2814	Major facilitator Superfamily
L2Z38_09855	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z38_09870	COG1960	acyl-CoA dehydrogenase activity
L2Z38_09875	COG1960	acyl-CoA dehydrogenase activity
L2Z38_09880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z38_09885	COG2207	Transcriptional regulator
L2Z38_09890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z38_09895	COG0776	regulation of translation
L2Z38_09920	COG0822	iron-sulfur transferase activity
L2Z38_09925	COG0316	Belongs to the HesB IscA family
L2Z38_09955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z38_09975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z38_09980	COG0702	epimerase
L2Z38_10015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z38_10025	COG0339	signal peptide processing
L2Z38_10045	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L2Z38_10070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z38_10075	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z38_10105	COG0776	regulation of translation
L2Z38_10170	COG0084	hydrolase, TatD family'
L2Z38_10190	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z38_10195	COG1132	(ABC) transporter
L2Z38_10205	COG0811	peptide transport
L2Z38_10210	COG1475	DNA binding
L2Z38_10215	COG1192	Involved in chromosome partitioning
L2Z38_10225	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z38_10240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z38_10245	COG0191	fructose-bisphosphate aldolase activity
L2Z38_10265	COG0424	maF-like protein
L2Z38_10270	COG2850	peptidyl-arginine hydroxylation
L2Z38_10280	COG0640	Transcriptional regulator
L2Z38_10290	COG3619	membrane
L2Z38_10295	COG3122	Protein conserved in bacteria
L2Z38_10300	COG1132	(ABC) transporter
L2Z38_10320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z38_10325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z38_10335	COG0506	proline dehydrogenase activity
L2Z38_10335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z38_10335	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z38_10340	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z38_10355	COG3698	Phosphodiester glycosidase
L2Z38_10365	COG2353	YceI-like domain
L2Z38_10380	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z38_10425	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z38_10425	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z38_10450	COG3539	Fimbrial protein
L2Z38_10455	COG3121	Chaperone
L2Z38_10480	COG0697	spore germination
L2Z38_10490	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z38_10500	COG0583	DNA-binding transcription factor activity
L2Z38_10520	COG1309	transcriptional regulator
L2Z38_10535	COG1522	sequence-specific DNA binding
L2Z38_10545	COG1126	abc transporter atp-binding protein
L2Z38_10550	COG0765	amino acid transport
L2Z38_10555	COG0765	amino acid transport
L2Z38_10585	COG1464	Belongs to the NlpA lipoprotein family
L2Z38_10595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z38_10600	COG2011	ABC-type metal ion transport system permease component
L2Z38_10605	COG0012	GTP binding
L2Z38_10630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z38_10670	COG0386	Belongs to the glutathione peroxidase family
L2Z38_10680	COG0436	Aminotransferase
L2Z38_10685	COG1301	dicarboxylic acid transport
L2Z38_10720	COG3634	alkyl hydroperoxide reductase activity
L2Z38_10735	COG0583	DNA-binding transcription factor activity
L2Z38_10740	COG0798	PFAM Bile acid sodium symporter
L2Z38_10745	COG0640	Transcriptional regulator
L2Z38_10760	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z38_10770	COG0583	DNA-binding transcription factor activity
L2Z38_10780	COG1953	Uracil, thiamine, allantoin
L2Z38_10790	COG2175	clavaminate synthase activity
L2Z38_10795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z38_10800	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z38_10805	COG4521	taurine ABC transporter
L2Z38_10815	COG0477	Major facilitator Superfamily
L2Z38_10840	COG1271	oxidase subunit
L2Z38_10845	COG1294	oxidase, subunit
L2Z38_10855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z38_10875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z38_10895	COG3052	prosthetic group binding
L2Z38_10900	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z38_10910	COG2814	Major facilitator Superfamily
L2Z38_10925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z38_10930	COG1346	cytolysis
L2Z38_10940	COG0583	DNA-binding transcription factor activity
L2Z38_10945	COG0625	glutathione transferase activity
L2Z38_10950	COG0625	glutathione transferase activity
L2Z38_10955	COG0583	DNA-binding transcription factor activity
L2Z38_10970	COG1045	serine acetyltransferase
L2Z38_10975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z38_10980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z38_10990	COG1280	lysine exporter protein (LysE YggA)
L2Z38_11005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z38_11010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z38_11015	COG1126	abc transporter atp-binding protein
L2Z38_11020	COG0765	amino acid transport
L2Z38_11025	COG0765	amino acid transport
L2Z38_11045	COG0784	Response regulator, receiver
L2Z38_11045	COG2205	protein histidine kinase activity
L2Z38_11090	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_11140	COG0583	DNA-binding transcription factor activity
L2Z38_11160	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z38_11165	COG1309	transcriptional regulator
L2Z38_11170	COG1960	acyl-CoA dehydrogenase activity
L2Z38_11175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z38_11180	COG1024	Enoyl-CoA hydratase
L2Z38_11185	COG4770	biotin carboxylase activity
L2Z38_11195	COG0583	DNA-binding transcription factor activity
L2Z38_11210	COG1960	acyl-CoA dehydrogenase activity
L2Z38_11220	COG2814	Major facilitator Superfamily
L2Z38_11230	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z38_11235	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z38_11240	COG2814	Major facilitator Superfamily
L2Z38_11245	COG1960	acyl-CoA dehydrogenase activity
L2Z38_11250	COG1024	Enoyl-CoA hydratase
L2Z38_11255	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_11260	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z38_11265	COG0183	Belongs to the thiolase family
L2Z38_11275	COG2814	Major facilitator Superfamily
L2Z38_11285	COG1024	Enoyl-CoA hydratase
L2Z38_11295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z38_11300	COG1960	acyl-CoA dehydrogenase activity
L2Z38_11305	COG2814	Major facilitator Superfamily
L2Z38_11310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z38_11315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z38_11330	COG3842	ATPase activity
L2Z38_11335	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z38_11345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z38_11350	COG1414	Transcriptional regulator
L2Z38_11360	COG0583	DNA-binding transcription factor activity
L2Z38_11365	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z38_11370	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_11380	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z38_11390	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_11395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z38_11400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z38_11405	COG2267	carboxylic ester hydrolase activity
L2Z38_11425	COG3038	cytochrome b561
L2Z38_11435	COG2271	Major facilitator Superfamily
L2Z38_11440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z38_11445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z38_11475	COG1278	Cold shock
L2Z38_11510	COG0210	DNA helicase
L2Z38_11515	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2Z38_11520	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z38_11530	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z38_11535	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z38_11540	COG0183	Belongs to the thiolase family
L2Z38_11545	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z38_11550	COG1024	Enoyl-CoA hydratase
L2Z38_11555	COG1024	Enoyl-CoA hydratase
L2Z38_11560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z38_11565	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z38_11570	COG3396	Phenylacetate-CoA oxygenase
L2Z38_11575	COG3460	Phenylacetate-CoA oxygenase
L2Z38_11580	COG3396	Phenylacetate-CoA oxygenase
L2Z38_11585	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_11585	COG2030	dehydratase
L2Z38_11590	COG1760	l-serine dehydratase
L2Z38_11595	COG0531	amino acid
L2Z38_11600	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_11625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z38_11645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z38_11655	COG0789	Transcriptional regulator
L2Z38_11665	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z38_11680	COG2807	transmembrane transport
L2Z38_11685	COG0590	tRNA wobble adenosine to inosine editing
L2Z38_11805	COG1116	anion transmembrane transporter activity
L2Z38_11810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z38_11820	COG0864	Transcriptional regulator
L2Z38_11830	COG1733	regulation of RNA biosynthetic process
L2Z38_11835	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z38_11840	COG0439	Biotin carboxylase
L2Z38_11855	COG1063	alcohol dehydrogenase
L2Z38_11865	COG1309	transcriptional regulator
L2Z38_11890	COG0038	chloride channel
L2Z38_11895	COG4770	biotin carboxylase activity
L2Z38_11915	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z38_11920	COG0583	DNA-binding transcription factor activity
L2Z38_11940	COG3209	COG3209 Rhs family protein
L2Z38_11985	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z38_12005	COG2814	Major facilitator Superfamily
L2Z38_12020	COG1560	Kdo2-lipid A biosynthetic process
L2Z38_12030	COG5006	permease, DMT superfamily
L2Z38_12035	COG1522	sequence-specific DNA binding
L2Z38_12050	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z38_12060	COG4122	O-methyltransferase activity
L2Z38_12090	COG1538	Outer membrane efflux protein
L2Z38_12095	COG1137	ATPase activity
L2Z38_12100	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z38_12110	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z38_12175	COG5434	Belongs to the glycosyl hydrolase 28 family
L2Z38_12190	COG3566	protein conserved in bacteria
L2Z38_12210	COG3567	Phage-associated protein, HI1409 family
L2Z38_12215	COG5410	chromosome segregation
L2Z38_12285	COG2814	Major facilitator Superfamily
L2Z38_12320	COG1278	Cold shock
L2Z38_12325	COG1280	lysine exporter protein (LysE YggA)
L2Z38_12355	COG1570	exodeoxyribonuclease VII activity
L2Z38_12405	COG0583	DNA-binding transcription factor activity
L2Z38_12415	COG4638	Rieske (2fe-2S)
L2Z38_12425	COG0543	2 iron, 2 sulfur cluster binding
L2Z38_12425	COG0633	Ferredoxin
L2Z38_12430	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_12435	COG3135	benzoate transporter
L2Z38_12440	COG2814	Major facilitator Superfamily
L2Z38_12455	COG1643	Atp-dependent helicase
L2Z38_12460	COG0450	alkyl hydroperoxide reductase
L2Z38_12480	COG3634	alkyl hydroperoxide reductase activity
L2Z38_12500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z38_12505	COG0625	glutathione transferase activity
L2Z38_12515	COG2885	chlorophyll binding
L2Z38_12550	COG0542	response to heat
L2Z38_12565	COG1765	OsmC-like protein
L2Z38_12580	COG0667	Aldo Keto reductase
L2Z38_12595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z38_12605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z38_12615	COG0527	aspartate kinase activity
L2Z38_12625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z38_12635	COG3038	cytochrome b561
L2Z38_12640	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z38_12645	COG2252	PERMEase
L2Z38_12655	COG2072	flavoprotein involved in K transport
L2Z38_12670	COG1741	Belongs to the pirin family
L2Z38_12675	COG1309	transcriptional regulator
L2Z38_12685	COG0300	oxidoreductase activity
L2Z38_12690	COG2072	flavoprotein involved in K transport
L2Z38_12695	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L2Z38_12740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z38_12755	COG2814	Major facilitator Superfamily
L2Z38_12760	COG1024	Enoyl-CoA hydratase
L2Z38_12765	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_12775	COG1960	acyl-CoA dehydrogenase activity
L2Z38_12800	COG2186	Transcriptional regulator
L2Z38_12805	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_12815	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z38_12820	COG2271	Major facilitator Superfamily
L2Z38_12825	COG2721	sulfolactate sulfo-lyase activity
L2Z38_12830	COG0697	spore germination
L2Z38_12860	COG1113	amino acid transport
L2Z38_12880	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_12900	COG0531	amino acid
L2Z38_12910	COG1113	amino acid transport
L2Z38_12940	COG3209	COG3209 Rhs family protein
L2Z38_12970	COG1902	pentaerythritol trinitrate reductase activity
L2Z38_12970	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z38_12980	COG3706	GGDEF domain
L2Z38_12980	COG5001	Diguanylate cyclase
L2Z38_12980	COG2203	Gaf domain
L2Z38_12980	COG4251	negative regulation of phosphorylation
L2Z38_12990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z38_13045	COG4172	Belongs to the ABC transporter superfamily
L2Z38_13050	COG4239	(ABC) transporter, permease
L2Z38_13055	COG4174	ABC transporter (Permease)
L2Z38_13065	COG0741	lytic transglycosylase activity
L2Z38_13065	COG0741	lytic transglycosylase activity
L2Z38_13065	COG1388	LysM domain
L2Z38_13065	COG1388	LysM domain
L2Z38_13070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z38_13110	COG0583	DNA-binding transcription factor activity
L2Z38_13115	COG1279	arginine transmembrane transporter activity
L2Z38_13135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z38_13140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z38_13145	COG0006	proline dipeptidase activity
L2Z38_13185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z38_13205	COG3384	dioxygenase
L2Z38_13215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z38_13220	COG2878	Part of a membrane complex involved in electron transport
L2Z38_13225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z38_13250	COG0768	penicillin binding
L2Z38_13255	COG0742	ribosomal rna small subunit methyltransferase
L2Z38_13270	COG0830	nickel cation binding
L2Z38_13280	COG0804	urea catabolic process
L2Z38_13320	COG1253	flavin adenine dinucleotide binding
L2Z38_13325	COG2851	Citrate transporter
L2Z38_13375	COG1773	rubredoxin
L2Z38_13380	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z38_13390	COG0583	DNA-binding transcription factor activity
L2Z38_13420	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z38_13425	COG4181	ATPase activity
L2Z38_13470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z38_13490	COG0306	phosphate transporter
L2Z38_13500	COG3958	Transketolase
L2Z38_13505	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z38_13510	COG2271	Major facilitator Superfamily
L2Z38_13515	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_13520	COG0583	DNA-binding transcription factor activity
L2Z38_13535	COG2223	nitrite transmembrane transporter activity
L2Z38_13540	COG2207	Transcriptional regulator
L2Z38_13545	COG2066	Belongs to the glutaminase family
L2Z38_13550	COG0242	peptide deformylase activity
L2Z38_13555	COG0477	Major facilitator Superfamily
L2Z38_13565	COG0028	Belongs to the TPP enzyme family
L2Z38_13580	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_13585	COG2267	carboxylic ester hydrolase activity
L2Z38_13595	COG2271	Major facilitator Superfamily
L2Z38_13600	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z38_13610	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_13630	COG1414	Transcriptional regulator
L2Z38_13645	COG1024	Enoyl-CoA hydratase
L2Z38_13655	COG1215	transferase activity, transferring glycosyl groups
L2Z38_13660	COG0726	polysaccharide deacetylase
L2Z38_13660	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z38_13670	COG4681	YaeQ
L2Z38_13680	COG0523	cobalamin synthesis protein
L2Z38_13690	COG1607	acyl-coa hydrolase
L2Z38_13700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z38_13705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z38_13710	COG1309	transcriptional regulator
L2Z38_13740	COG2040	homocysteine
L2Z38_13745	COG0531	amino acid
L2Z38_13800	COG1595	DNA-templated transcription, initiation
L2Z38_13810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z38_13815	COG0477	Major facilitator Superfamily
L2Z38_13835	COG0084	hydrolase, TatD family'
L2Z38_13870	COG0629	single-stranded DNA binding
L2Z38_13925	COG0582	viral genome integration into host DNA
L2Z38_13935	COG0405	Gamma-glutamyltransferase
L2Z38_13940	COG2814	Major facilitator Superfamily
L2Z38_13950	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z38_13965	COG1090	epimerase
L2Z38_13985	COG0420	3'-5' exonuclease activity
L2Z38_14010	COG0735	belongs to the Fur family
L2Z38_14015	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z38_14035	COG0121	glutamine amidotransferase
L2Z38_14050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z38_14060	COG0210	DNA helicase
L2Z38_14065	COG2885	chlorophyll binding
L2Z38_14070	COG0204	Acyl-transferase
L2Z38_14085	COG2894	cell division
L2Z38_14100	COG1280	lysine exporter protein (LysE YggA)
L2Z38_14105	COG1674	ftsk spoiiie
L2Z38_14105	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z38_14110	COG0492	ferredoxin-NADP+ reductase activity
L2Z38_14115	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z38_14125	COG0456	acetyltransferase
L2Z38_14170	COG1981	membrane
L2Z38_14185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z38_14185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z38_14205	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_14215	COG0657	acetylesterase activity
L2Z38_14225	COG0473	3-isopropylmalate dehydrogenase activity
L2Z38_14230	COG0583	DNA-binding transcription factor activity
L2Z38_14250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z38_14275	COG0564	pseudouridine synthase activity
L2Z38_14285	COG0358	DNA primase activity
L2Z38_14300	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z38_14330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z38_14360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z38_14370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z38_14370	COG0352	thiamine-phosphate diphosphorylase activity
L2Z38_14370	COG0351	phosphomethylpyrimidine kinase
L2Z38_14375	COG1652	LysM domain
L2Z38_14400	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z38_14405	COG3101	peptidyl-lysine hydroxylation
L2Z38_14410	COG0009	L-threonylcarbamoyladenylate synthase
L2Z38_14415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z38_14420	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z38_14435	COG4106	trans-aconitate 2-methyltransferase activity
L2Z38_14450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z38_14450	COG0596	Alpha beta hydrolase
L2Z38_14450	COG2226	methyltransferase
L2Z38_14460	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z38_14465	COG2223	nitrite transmembrane transporter activity
L2Z38_14485	COG1196	nuclear chromosome segregation
L2Z38_14495	COG0730	response to heat
L2Z38_14510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z38_14520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z38_14570	COG0489	protein tyrosine kinase activity
L2Z38_14580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z38_14580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z38_14610	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z38_14615	COG2081	HI0933 family
L2Z38_14625	COG0668	transmembrane transport
L2Z38_14645	COG0583	DNA-binding transcription factor activity
L2Z38_14670	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z38_14675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z38_14705	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z38_14745	COG0745	RESPONSE REGULATOR receiver
L2Z38_14765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z38_14775	COG0384	phenazine biosynthesis protein PhzF
L2Z38_14805	COG1309	transcriptional regulator
L2Z38_14810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z38_14825	COG0583	DNA-binding transcription factor activity
L2Z38_14855	COG0583	DNA-binding transcription factor activity
L2Z38_14870	COG0583	DNA-binding transcription factor activity
L2Z38_14875	COG1053	succinate dehydrogenase
L2Z38_14885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z38_14890	COG2814	Major facilitator Superfamily
L2Z38_14895	COG1960	acyl-CoA dehydrogenase activity
L2Z38_14900	COG0583	DNA-binding transcription factor activity
L2Z38_14905	COG1063	alcohol dehydrogenase
L2Z38_14935	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z38_14940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z38_14945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z38_14960	COG3667	copper resistance
L2Z38_14965	COG2132	Multicopper oxidase
L2Z38_14975	COG0561	phosphatase activity
L2Z38_14980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z38_14990	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L2Z38_15005	COG1214	PFAM Peptidase M22, glycoprotease
L2Z38_15055	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z38_15065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z38_15070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z38_15075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z38_15135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z38_15145	COG1846	Transcriptional regulator
L2Z38_15150	COG1764	response to oxidative stress
L2Z38_15190	COG0037	tRNA processing
L2Z38_15200	COG0248	Ppx GppA phosphatase
L2Z38_15230	COG0072	phenylalanine-tRNA ligase activity
L2Z38_15275	COG1238	metal cluster binding
L2Z38_15280	COG0625	glutathione transferase activity
L2Z38_15295	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z38_15300	COG3028	Belongs to the UPF0307 family
L2Z38_15305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z38_15325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z38_15330	COG0617	tRNA 3'-terminal CCA addition
L2Z38_15335	COG1555	photosystem II stabilization
L2Z38_15340	COG3956	TIGRFAM MazG family protein
L2Z38_15350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z38_15370	COG0784	Response regulator, receiver
L2Z38_15370	COG2205	protein histidine kinase activity
L2Z38_15370	COG5002	protein histidine kinase activity
L2Z38_15375	COG1024	Enoyl-CoA hydratase
L2Z38_15380	COG2084	Dehydrogenase
L2Z38_15385	COG3622	Belongs to the hyi family
L2Z38_15415	COG0697	spore germination
L2Z38_15425	COG2814	Major facilitator Superfamily
L2Z38_15445	COG2132	Multicopper oxidase
L2Z38_15460	COG2205	protein histidine kinase activity
L2Z38_15550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z38_15560	COG0583	DNA-binding transcription factor activity
L2Z38_15570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z38_15580	COG0084	hydrolase, TatD family'
L2Z38_15595	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z38_15615	COG3676	manually curated
L2Z38_15630	COG0440	acetolactate synthase activity
L2Z38_15635	COG0028	Belongs to the TPP enzyme family
L2Z38_15660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z38_15665	COG0577	efflux transmembrane transporter activity
L2Z38_15665	COG1136	(ABC) transporter
L2Z38_15670	COG1538	Outer membrane efflux protein
L2Z38_15685	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z38_15690	COG1162	GTPase activity
L2Z38_15700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z38_15740	COG1426	Protein conserved in bacteria
L2Z38_15775	COG0793	Belongs to the peptidase S41A family
L2Z38_15790	COG2267	carboxylic ester hydrolase activity
L2Z38_15800	COG1012	belongs to the aldehyde dehydrogenase family
L2Z38_15805	COG3265	gluconokinase activity
L2Z38_15815	COG0800	Aldolase
L2Z38_15825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z38_15830	COG0857	belongs to the CobB CobQ family
L2Z38_15830	COG0280	phosphate acetyltransferase
L2Z38_15835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z38_15835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z38_15855	COG0740	serine-type endopeptidase activity
L2Z38_15865	COG4774	siderophore transport
L2Z38_15875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z38_15885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z38_15885	COG2813	Specifically methylates the guanine in position
L2Z38_15985	COG0788	formyltetrahydrofolate deformylase activity
L2Z38_16010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z38_16010	COG4651	solute:proton antiporter activity
L2Z38_16030	COG0724	RNA recognition motif
L2Z38_16035	COG0210	DNA helicase
L2Z38_16060	COG1733	regulation of RNA biosynthetic process
L2Z38_16070	COG2900	Belongs to the SlyX family
L2Z38_16075	COG0488	(ABC) transporter
L2Z38_16080	COG1280	lysine exporter protein (LysE YggA)
L2Z38_16085	COG1560	Kdo2-lipid A biosynthetic process
L2Z38_16095	COG1301	dicarboxylic acid transport
L2Z38_16150	COG0473	3-isopropylmalate dehydrogenase activity
L2Z38_16205	COG0583	DNA-binding transcription factor activity
L2Z38_16215	COG0625	glutathione transferase activity
L2Z38_16220	COG2378	regulation of single-species biofilm formation
L2Z38_16225	COG0546	phosphoglycolate phosphatase activity
L2Z38_16240	COG1530	ribonuclease E activity
L2Z38_16245	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z38_16260	COG0583	DNA-binding transcription factor activity
L2Z38_16265	COG4221	oxidoreductase activity
L2Z38_16270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z38_16280	COG0534	Mate efflux family protein
L2Z38_16295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z38_16320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z38_16320	COG0493	'glutamate synthase
L2Z38_16330	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z38_16335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z38_16350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z38_16360	COG0644	oxidoreductase
L2Z38_16360	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z38_16370	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z38_16375	COG4535	Mg2 and Co2 transporter CorC
L2Z38_16385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z38_16405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z38_16410	COG0475	glutathione-regulated potassium exporter activity
L2Z38_16410	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z38_16425	COG0484	heat shock protein binding
L2Z38_16430	COG0789	Transcriptional regulator
L2Z38_16435	COG0598	Magnesium transport protein CorA
L2Z38_16450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z38_16455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z38_16460	COG1074	ATP-dependent DNA helicase activity
L2Z38_16465	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z38_16485	COG2226	methyltransferase
L2Z38_16500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z38_16505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z38_16520	COG2111	Na H antiporter
L2Z38_16520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z38_16525	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z38_16530	COG0651	ATP synthesis coupled electron transport
L2Z38_16535	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z38_16540	COG2212	antiporter activity
L2Z38_16545	COG1320	monovalent cation:proton antiporter activity
L2Z38_16560	COG0195	Participates in both transcription termination and antitermination
L2Z38_16610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z38_16615	COG0237	dephospho-CoA kinase activity
L2Z38_16625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z38_16640	COG0497	DNA recombination
L2Z38_16650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z38_16680	COG2169	Transcriptional regulator
L2Z38_16680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z38_16685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z38_16745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z38_16760	COG0326	Molecular chaperone. Has ATPase activity
L2Z38_16775	COG2056	Na+-H+ antiporter family
L2Z38_16875	COG0546	phosphoglycolate phosphatase activity
L2Z38_16880	COG1716	ATPase activity
L2Z38_16925	COG0181	hydroxymethylbilane synthase activity
L2Z38_16935	COG3275	phosphorelay sensor kinase activity
L2Z38_16955	COG1538	Outer membrane efflux protein
L2Z38_16960	COG0697	spore germination
L2Z38_16985	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z38_16990	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z38_16995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z38_17000	COG0772	Belongs to the SEDS family
L2Z38_17025	COG4974	Belongs to the 'phage' integrase family
L2Z38_17030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z38_17040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z38_17050	COG2197	response regulator
L2Z38_17065	COG0793	Belongs to the peptidase S41A family
L2Z38_17070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z38_17075	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z38_17115	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z38_17115	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z38_17125	COG0004	ammonium transporteR
L2Z38_17130	COG0347	Belongs to the P(II) protein family
L2Z38_17150	COG0659	secondary active sulfate transmembrane transporter activity
L2Z38_17175	COG0789	Transcriptional regulator
L2Z38_17190	COG0640	Transcriptional regulator
L2Z38_17200	COG0798	PFAM Bile acid sodium symporter
L2Z38_17205	COG0431	NADPH-dependent FMN reductase
L2Z38_17210	COG0492	ferredoxin-NADP+ reductase activity
L2Z38_17215	COG2072	flavoprotein involved in K transport
L2Z38_17260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z38_17275	COG3676	manually curated
L2Z38_17285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z38_17300	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z38_17310	COG0477	Major facilitator Superfamily
L2Z38_17315	COG2860	membrane
L2Z38_17320	COG3012	SEC-C Motif Domain Protein
L2Z38_17325	COG1253	flavin adenine dinucleotide binding
L2Z38_17335	COG0477	Major facilitator Superfamily
L2Z38_17345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z38_17385	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z38_17395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z38_17465	COG0758	DNA mediated transformation
L2Z38_17475	COG0697	spore germination
L2Z38_17480	COG1309	transcriptional regulator
L2Z38_17495	COG0386	Belongs to the glutathione peroxidase family
L2Z38_17560	COG1121	(ABC) transporter
L2Z38_17565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z38_17570	COG1280	lysine exporter protein (LysE YggA)
L2Z38_17575	COG2837	iron assimilation
L2Z38_17580	COG0281	malic enzyme
L2Z38_17625	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z38_17625	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z38_17630	COG4399	Belongs to the UPF0754 family
L2Z38_17635	COG2259	Doxx family
L2Z38_17640	COG0586	Pfam SNARE associated Golgi protein
L2Z38_17655	COG1192	Involved in chromosome partitioning
L2Z38_17665	COG0271	Belongs to the BolA IbaG family
L2Z38_17685	COG2267	carboxylic ester hydrolase activity
L2Z38_17705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z38_17705	COG3321	synthase
L2Z38_17705	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z38_17705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z38_17710	COG1960	acyl-CoA dehydrogenase activity
L2Z38_17720	COG2197	response regulator
L2Z38_17730	COG3916	Acyl-homoserine-lactone synthase
L2Z38_17735	COG0477	Major facilitator Superfamily
L2Z38_17740	COG1024	Enoyl-CoA hydratase
L2Z38_17745	COG1024	Enoyl-CoA hydratase
L2Z38_17750	COG1960	acyl-CoA dehydrogenase activity
L2Z38_17755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z38_17775	COG1113	amino acid transport
L2Z38_17780	COG1113	amino acid transport
L2Z38_17785	COG0251	oxidation-reduction process
L2Z38_17825	COG0564	pseudouridine synthase activity
L2Z38_17840	COG3328	transposase activity
L2Z38_17870	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z38_17885	COG1802	Transcriptional regulator
L2Z38_17890	COG1448	Aminotransferase
L2Z38_17895	COG0277	FAD linked oxidase domain protein
L2Z38_17905	COG2186	Transcriptional regulator
L2Z38_17915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z38_17920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z38_17935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z38_17950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z38_17960	COG0110	maltose O-acetyltransferase activity
L2Z38_17965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z38_17975	COG0438	transferase activity, transferring glycosyl groups
L2Z38_17980	COG0438	transferase activity, transferring glycosyl groups
L2Z38_17990	COG0438	transferase activity, transferring glycosyl groups
L2Z38_18005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z38_18010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z38_18015	COG1596	polysaccharide export
L2Z38_18040	COG0728	peptidoglycan biosynthetic process
L2Z38_18045	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z38_18100	COG0546	phosphoglycolate phosphatase activity
L2Z38_18105	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z38_18125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z38_18130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z38_18135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z38_18140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z38_18150	COG1309	transcriptional regulator
L2Z38_18155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z38_18165	COG0196	riboflavin kinase activity
L2Z38_18170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z38_18180	COG1047	Peptidyl-prolyl cis-trans
L2Z38_18220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z38_18225	COG0657	acetylesterase activity
L2Z38_18245	COG0583	DNA-binding transcription factor activity
L2Z38_18275	COG2951	lytic endotransglycosylase activity
L2Z38_18280	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z38_18295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z38_18305	COG0671	phosphoesterase, PA-phosphatase related
L2Z38_18310	COG0861	Integral membrane protein TerC family
L2Z38_18320	COG0754	glutathionylspermidine amidase activity
L2Z38_18330	COG0402	S-adenosylhomocysteine deaminase activity
L2Z38_18345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z38_18350	COG1230	cation diffusion facilitator family transporter
L2Z38_18365	COG0706	membrane insertase activity
L2Z38_18390	COG0592	DNA-directed DNA polymerase activity
L2Z38_18400	COG0187	DNA topoisomerase II activity
L2Z38_18410	COG0586	Pfam SNARE associated Golgi protein
L2Z38_18415	COG0488	(ABC) transporter
L2Z38_18440	COG0596	Alpha beta hydrolase
L2Z38_18445	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z38_18450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)