locus-tag	class	description
L2Z40_00010	COG1183	phosphatidylcholine synthase activity
L2Z40_00015	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z40_00045	COG0739	heme binding
L2Z40_00045	COG0741	lytic transglycosylase activity
L2Z40_00045	COG1196	nuclear chromosome segregation
L2Z40_00055	COG1702	phosphate starvation-inducible protein PhoH
L2Z40_00090	COG1295	ribonuclease BN
L2Z40_00095	COG0697	spore germination
L2Z40_00100	COG2169	Transcriptional regulator
L2Z40_00105	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z40_00150	COG0557	exoribonuclease II activity
L2Z40_00155	COG0339	signal peptide processing
L2Z40_00160	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z40_00190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z40_00195	COG1960	acyl-CoA dehydrogenase activity
L2Z40_00350	COG0626	cystathionine gamma-synthase activity
L2Z40_00355	COG0433	COG0433 Predicted ATPase
L2Z40_00360	COG1017	nitric oxide dioxygenase activity
L2Z40_00360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_00365	COG1959	2 iron, 2 sulfur cluster binding
L2Z40_00380	COG1301	dicarboxylic acid transport
L2Z40_00385	COG1946	Acyl-CoA thioesterase
L2Z40_00405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z40_00410	COG1040	competence protein
L2Z40_00415	COG0494	nUDIX hydrolase
L2Z40_00425	COG0598	Magnesium transport protein CorA
L2Z40_00435	COG2854	intermembrane phospholipid transfer
L2Z40_00445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z40_00450	COG1127	ABC transporter
L2Z40_00460	COG0513	Belongs to the DEAD box helicase family
L2Z40_00480	COG0408	coproporphyrinogen oxidase activity
L2Z40_00495	COG1960	acyl-CoA dehydrogenase activity
L2Z40_00505	COG1983	PspC domain protein
L2Z40_00510	COG0517	IMP dehydrogenase activity
L2Z40_00560	COG0583	DNA-binding transcription factor activity
L2Z40_00600	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_00610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z40_00615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z40_00620	COG0833	amino acid
L2Z40_00650	COG1192	Involved in chromosome partitioning
L2Z40_00655	COG0628	permease
L2Z40_00665	COG1289	transmembrane transporter activity
L2Z40_00680	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z40_00685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z40_00695	COG0277	FAD linked oxidase domain protein
L2Z40_00700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z40_00725	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z40_00730	COG5380	lipid catabolic process
L2Z40_00750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z40_00800	COG0194	GDP metabolic process
L2Z40_00815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z40_00850	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z40_00855	COG1704	LemA family
L2Z40_00865	COG0493	'glutamate synthase
L2Z40_00870	COG0070	glutamate synthase
L2Z40_00870	COG0069	glutamate synthase activity
L2Z40_00870	COG0067	glutamate synthase
L2Z40_00920	COG2226	methyltransferase
L2Z40_00935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z40_00940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z40_00985	COG0833	amino acid
L2Z40_01050	COG0488	(ABC) transporter
L2Z40_01055	COG2873	o-acetylhomoserine
L2Z40_01060	COG4221	oxidoreductase activity
L2Z40_01065	COG0659	secondary active sulfate transmembrane transporter activity
L2Z40_01095	COG0427	acetyl-CoA hydrolase
L2Z40_01125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z40_01165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z40_01225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2Z40_01235	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z40_01240	COG1733	regulation of RNA biosynthetic process
L2Z40_01255	COG1733	regulation of RNA biosynthetic process
L2Z40_01275	COG0667	Aldo Keto reductase
L2Z40_01295	COG0583	DNA-binding transcription factor activity
L2Z40_01300	COG2814	Major facilitator Superfamily
L2Z40_01330	COG1335	isochorismatase
L2Z40_01340	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_01345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z40_01355	COG1113	amino acid transport
L2Z40_01365	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z40_01380	COG2814	Major facilitator Superfamily
L2Z40_01390	COG0351	phosphomethylpyrimidine kinase
L2Z40_01390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z40_01390	COG0352	thiamine-phosphate diphosphorylase activity
L2Z40_01410	COG1309	transcriptional regulator
L2Z40_01415	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z40_01430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_01440	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z40_01445	COG3162	membrane
L2Z40_01450	COG2198	Histidine kinase
L2Z40_01450	COG2205	protein histidine kinase activity
L2Z40_01450	COG0784	Response regulator, receiver
L2Z40_01475	COG1522	sequence-specific DNA binding
L2Z40_01480	COG1335	isochorismatase
L2Z40_01485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z40_01495	COG0668	transmembrane transport
L2Z40_01500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z40_01505	COG1519	Transferase
L2Z40_01510	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_01530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z40_01555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_01555	COG0426	domain, Protein
L2Z40_01560	COG4774	siderophore transport
L2Z40_01565	COG2119	membrane
L2Z40_01575	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z40_01585	COG4942	peptidase
L2Z40_01600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z40_01610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z40_01630	COG0189	ligase activity
L2Z40_01650	COG0708	Exodeoxyribonuclease III
L2Z40_01655	COG1393	Belongs to the ArsC family
L2Z40_01670	COG3706	GGDEF domain
L2Z40_01705	COG2351	hydroxyisourate hydrolase activity
L2Z40_01710	COG2233	PERMEase
L2Z40_01720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_01730	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z40_01740	COG3150	esterase
L2Z40_01770	COG3409	Peptidoglycan-binding domain 1 protein
L2Z40_01770	COG1388	LysM domain
L2Z40_01770	COG5632	N-Acetylmuramoyl-L-alanine amidase
L2Z40_01785	COG2918	glutathione biosynthetic process
L2Z40_01800	COG2733	membrane
L2Z40_01805	COG0436	Aminotransferase
L2Z40_01810	COG0534	Mate efflux family protein
L2Z40_01895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z40_01900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z40_01910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z40_01945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z40_01960	COG0010	Belongs to the arginase family
L2Z40_01990	COG2188	Transcriptional regulator
L2Z40_02000	COG0523	cobalamin synthesis protein
L2Z40_02010	COG1113	amino acid transport
L2Z40_02020	COG0625	glutathione transferase activity
L2Z40_02040	COG1683	Conserved Protein
L2Z40_02045	COG0534	Mate efflux family protein
L2Z40_02050	COG0385	Bile acid
L2Z40_02055	COG1335	isochorismatase
L2Z40_02060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z40_02075	COG3676	manually curated
L2Z40_02085	COG2116	formate transmembrane transporter activity
L2Z40_02090	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z40_02095	COG2133	pyrroloquinoline quinone binding
L2Z40_02100	COG2983	Belongs to the UPF0260 family
L2Z40_02120	COG1194	a g-specific adenine glycosylase
L2Z40_02135	COG2818	Glycosylase
L2Z40_02140	COG1064	alcohol dehydrogenase
L2Z40_02145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z40_02160	COG0583	DNA-binding transcription factor activity
L2Z40_02165	COG0656	L-ascorbic acid biosynthetic process
L2Z40_02170	COG2814	Major facilitator Superfamily
L2Z40_02205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_02220	COG2233	PERMEase
L2Z40_02225	COG0583	DNA-binding transcription factor activity
L2Z40_02260	COG0733	neurotransmitter:sodium symporter activity
L2Z40_02300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z40_02305	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z40_02335	COG0488	(ABC) transporter
L2Z40_02340	COG0586	Pfam SNARE associated Golgi protein
L2Z40_02350	COG0187	DNA topoisomerase II activity
L2Z40_02360	COG0592	DNA-directed DNA polymerase activity
L2Z40_02385	COG0706	membrane insertase activity
L2Z40_02400	COG1230	cation diffusion facilitator family transporter
L2Z40_02405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z40_02420	COG0402	S-adenosylhomocysteine deaminase activity
L2Z40_02430	COG0754	glutathionylspermidine amidase activity
L2Z40_02440	COG0861	Integral membrane protein TerC family
L2Z40_02445	COG0671	phosphoesterase, PA-phosphatase related
L2Z40_02455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z40_02470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z40_02475	COG2951	lytic endotransglycosylase activity
L2Z40_02505	COG0583	DNA-binding transcription factor activity
L2Z40_02525	COG0657	acetylesterase activity
L2Z40_02530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z40_02570	COG1047	Peptidyl-prolyl cis-trans
L2Z40_02580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z40_02585	COG0196	riboflavin kinase activity
L2Z40_02595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z40_02600	COG1309	transcriptional regulator
L2Z40_02610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z40_02615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z40_02620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z40_02625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z40_02645	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_02650	COG0546	phosphoglycolate phosphatase activity
L2Z40_02705	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z40_02710	COG0728	peptidoglycan biosynthetic process
L2Z40_02735	COG1596	polysaccharide export
L2Z40_02740	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z40_02745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z40_02760	COG0438	transferase activity, transferring glycosyl groups
L2Z40_02770	COG0438	transferase activity, transferring glycosyl groups
L2Z40_02775	COG0438	transferase activity, transferring glycosyl groups
L2Z40_02785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2Z40_02790	COG0110	maltose O-acetyltransferase activity
L2Z40_02800	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z40_02815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z40_02820	COG3676	manually curated
L2Z40_02835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z40_02840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z40_02850	COG2186	Transcriptional regulator
L2Z40_02860	COG0277	FAD linked oxidase domain protein
L2Z40_02865	COG1448	Aminotransferase
L2Z40_02870	COG1802	Transcriptional regulator
L2Z40_02885	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z40_02910	COG3328	transposase activity
L2Z40_02925	COG0564	pseudouridine synthase activity
L2Z40_02965	COG0251	oxidation-reduction process
L2Z40_02970	COG1113	amino acid transport
L2Z40_02975	COG1113	amino acid transport
L2Z40_02995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z40_03000	COG1960	acyl-CoA dehydrogenase activity
L2Z40_03005	COG1024	Enoyl-CoA hydratase
L2Z40_03010	COG1024	Enoyl-CoA hydratase
L2Z40_03015	COG0477	Major facilitator Superfamily
L2Z40_03020	COG3916	Acyl-homoserine-lactone synthase
L2Z40_03030	COG2197	response regulator
L2Z40_03040	COG1960	acyl-CoA dehydrogenase activity
L2Z40_03045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z40_03045	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z40_03045	COG3321	synthase
L2Z40_03045	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z40_03065	COG2267	carboxylic ester hydrolase activity
L2Z40_03085	COG0271	Belongs to the BolA IbaG family
L2Z40_03095	COG1192	Involved in chromosome partitioning
L2Z40_03110	COG0586	Pfam SNARE associated Golgi protein
L2Z40_03115	COG2259	Doxx family
L2Z40_03120	COG4399	Belongs to the UPF0754 family
L2Z40_03125	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z40_03125	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z40_03170	COG0281	malic enzyme
L2Z40_03175	COG2837	iron assimilation
L2Z40_03180	COG1280	lysine exporter protein (LysE YggA)
L2Z40_03185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z40_03190	COG1121	(ABC) transporter
L2Z40_03255	COG0386	Belongs to the glutathione peroxidase family
L2Z40_03270	COG1309	transcriptional regulator
L2Z40_03275	COG0697	spore germination
L2Z40_03285	COG0758	DNA mediated transformation
L2Z40_03355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z40_03365	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z40_03405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z40_03415	COG0477	Major facilitator Superfamily
L2Z40_03425	COG1253	flavin adenine dinucleotide binding
L2Z40_03430	COG3012	SEC-C Motif Domain Protein
L2Z40_03435	COG2860	membrane
L2Z40_03440	COG0477	Major facilitator Superfamily
L2Z40_03450	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z40_03465	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z40_03475	COG3676	manually curated
L2Z40_03490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z40_03535	COG2072	flavoprotein involved in K transport
L2Z40_03540	COG0492	ferredoxin-NADP+ reductase activity
L2Z40_03545	COG0431	NADPH-dependent FMN reductase
L2Z40_03550	COG0798	PFAM Bile acid sodium symporter
L2Z40_03560	COG0640	Transcriptional regulator
L2Z40_03575	COG0789	Transcriptional regulator
L2Z40_03600	COG0659	secondary active sulfate transmembrane transporter activity
L2Z40_03620	COG0347	Belongs to the P(II) protein family
L2Z40_03625	COG0004	ammonium transporteR
L2Z40_03635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z40_03635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z40_03675	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z40_03680	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z40_03685	COG0793	Belongs to the peptidase S41A family
L2Z40_03700	COG2197	response regulator
L2Z40_03710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z40_03720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z40_03725	COG4974	Belongs to the 'phage' integrase family
L2Z40_03750	COG0772	Belongs to the SEDS family
L2Z40_03755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z40_03760	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z40_03765	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z40_03790	COG0697	spore germination
L2Z40_03795	COG1538	Outer membrane efflux protein
L2Z40_03815	COG3275	phosphorelay sensor kinase activity
L2Z40_03825	COG0181	hydroxymethylbilane synthase activity
L2Z40_03870	COG1716	ATPase activity
L2Z40_03875	COG0546	phosphoglycolate phosphatase activity
L2Z40_03975	COG2056	Na+-H+ antiporter family
L2Z40_03990	COG0326	Molecular chaperone. Has ATPase activity
L2Z40_04005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z40_04065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z40_04070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z40_04070	COG2169	Transcriptional regulator
L2Z40_04100	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z40_04110	COG0497	DNA recombination
L2Z40_04125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z40_04135	COG0237	dephospho-CoA kinase activity
L2Z40_04190	COG0195	Participates in both transcription termination and antitermination
L2Z40_04205	COG1320	monovalent cation:proton antiporter activity
L2Z40_04210	COG2212	antiporter activity
L2Z40_04215	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z40_04220	COG0651	ATP synthesis coupled electron transport
L2Z40_04225	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z40_04230	COG2111	Na H antiporter
L2Z40_04230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z40_04245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z40_04250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_04265	COG2226	methyltransferase
L2Z40_04285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z40_04290	COG1074	ATP-dependent DNA helicase activity
L2Z40_04295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z40_04300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z40_04315	COG0598	Magnesium transport protein CorA
L2Z40_04320	COG0789	Transcriptional regulator
L2Z40_04325	COG0484	heat shock protein binding
L2Z40_04340	COG0475	glutathione-regulated potassium exporter activity
L2Z40_04340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z40_04345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z40_04365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z40_04375	COG4535	Mg2 and Co2 transporter CorC
L2Z40_04380	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z40_04390	COG0644	oxidoreductase
L2Z40_04390	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z40_04400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z40_04415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z40_04420	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z40_04430	COG0493	'glutamate synthase
L2Z40_04430	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z40_04455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z40_04470	COG0534	Mate efflux family protein
L2Z40_04480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z40_04485	COG4221	oxidoreductase activity
L2Z40_04490	COG0583	DNA-binding transcription factor activity
L2Z40_04505	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z40_04510	COG1530	ribonuclease E activity
L2Z40_04525	COG0546	phosphoglycolate phosphatase activity
L2Z40_04530	COG2378	regulation of single-species biofilm formation
L2Z40_04535	COG0625	glutathione transferase activity
L2Z40_04545	COG0583	DNA-binding transcription factor activity
L2Z40_04600	COG0473	3-isopropylmalate dehydrogenase activity
L2Z40_04655	COG1301	dicarboxylic acid transport
L2Z40_04665	COG1560	Kdo2-lipid A biosynthetic process
L2Z40_04670	COG1280	lysine exporter protein (LysE YggA)
L2Z40_04675	COG0488	(ABC) transporter
L2Z40_04680	COG2900	Belongs to the SlyX family
L2Z40_04690	COG1733	regulation of RNA biosynthetic process
L2Z40_04715	COG0210	DNA helicase
L2Z40_04720	COG0724	RNA recognition motif
L2Z40_04740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z40_04740	COG4651	solute:proton antiporter activity
L2Z40_04765	COG0788	formyltetrahydrofolate deformylase activity
L2Z40_04865	COG2813	Specifically methylates the guanine in position
L2Z40_04865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z40_04875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z40_04885	COG4774	siderophore transport
L2Z40_04895	COG0740	serine-type endopeptidase activity
L2Z40_04915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z40_04915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z40_04920	COG0280	phosphate acetyltransferase
L2Z40_04920	COG0857	belongs to the CobB CobQ family
L2Z40_04925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z40_04935	COG0800	Aldolase
L2Z40_04945	COG3265	gluconokinase activity
L2Z40_04950	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_04960	COG2267	carboxylic ester hydrolase activity
L2Z40_04975	COG0793	Belongs to the peptidase S41A family
L2Z40_05010	COG1426	Protein conserved in bacteria
L2Z40_05050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z40_05060	COG1162	GTPase activity
L2Z40_05065	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z40_05080	COG1538	Outer membrane efflux protein
L2Z40_05085	COG1136	(ABC) transporter
L2Z40_05085	COG0577	efflux transmembrane transporter activity
L2Z40_05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_05115	COG0028	Belongs to the TPP enzyme family
L2Z40_05120	COG0440	acetolactate synthase activity
L2Z40_05135	COG3676	manually curated
L2Z40_05155	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z40_05170	COG0084	hydrolase, TatD family'
L2Z40_05180	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z40_05190	COG0583	DNA-binding transcription factor activity
L2Z40_05200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z40_05290	COG2205	protein histidine kinase activity
L2Z40_05305	COG2132	Multicopper oxidase
L2Z40_05325	COG2814	Major facilitator Superfamily
L2Z40_05335	COG0697	spore germination
L2Z40_05365	COG3622	Belongs to the hyi family
L2Z40_05370	COG2084	Dehydrogenase
L2Z40_05375	COG1024	Enoyl-CoA hydratase
L2Z40_05380	COG0784	Response regulator, receiver
L2Z40_05380	COG2205	protein histidine kinase activity
L2Z40_05380	COG5002	protein histidine kinase activity
L2Z40_05400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z40_05410	COG3956	TIGRFAM MazG family protein
L2Z40_05415	COG1555	photosystem II stabilization
L2Z40_05420	COG0617	tRNA 3'-terminal CCA addition
L2Z40_05425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z40_05445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z40_05450	COG3028	Belongs to the UPF0307 family
L2Z40_05455	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z40_05470	COG0625	glutathione transferase activity
L2Z40_05475	COG1238	metal cluster binding
L2Z40_05515	COG0072	phenylalanine-tRNA ligase activity
L2Z40_05545	COG0248	Ppx GppA phosphatase
L2Z40_05555	COG0037	tRNA processing
L2Z40_05595	COG1764	response to oxidative stress
L2Z40_05600	COG1846	Transcriptional regulator
L2Z40_05610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z40_05670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z40_05675	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z40_05680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z40_05690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z40_05740	COG1214	PFAM Peptidase M22, glycoprotease
L2Z40_05755	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L2Z40_05765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z40_05770	COG0561	phosphatase activity
L2Z40_05780	COG2132	Multicopper oxidase
L2Z40_05785	COG3667	copper resistance
L2Z40_05800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z40_05805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z40_05810	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z40_05840	COG1063	alcohol dehydrogenase
L2Z40_05845	COG0583	DNA-binding transcription factor activity
L2Z40_05850	COG1960	acyl-CoA dehydrogenase activity
L2Z40_05855	COG2814	Major facilitator Superfamily
L2Z40_05860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z40_05870	COG1053	succinate dehydrogenase
L2Z40_05875	COG0583	DNA-binding transcription factor activity
L2Z40_05890	COG0583	DNA-binding transcription factor activity
L2Z40_05920	COG0583	DNA-binding transcription factor activity
L2Z40_05935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_05940	COG1309	transcriptional regulator
L2Z40_05970	COG0384	phenazine biosynthesis protein PhzF
L2Z40_05980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z40_06000	COG0745	RESPONSE REGULATOR receiver
L2Z40_06040	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z40_06070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z40_06075	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z40_06100	COG0583	DNA-binding transcription factor activity
L2Z40_06120	COG0668	transmembrane transport
L2Z40_06130	COG2081	HI0933 family
L2Z40_06135	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z40_06165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z40_06165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z40_06175	COG0489	protein tyrosine kinase activity
L2Z40_06225	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z40_06235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z40_06250	COG0730	response to heat
L2Z40_06260	COG1196	nuclear chromosome segregation
L2Z40_06280	COG2223	nitrite transmembrane transporter activity
L2Z40_06285	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z40_06295	COG0596	Alpha beta hydrolase
L2Z40_06295	COG2226	methyltransferase
L2Z40_06295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z40_06310	COG4106	trans-aconitate 2-methyltransferase activity
L2Z40_06325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z40_06330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z40_06335	COG0009	L-threonylcarbamoyladenylate synthase
L2Z40_06340	COG3101	peptidyl-lysine hydroxylation
L2Z40_06345	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z40_06370	COG1652	LysM domain
L2Z40_06375	COG0351	phosphomethylpyrimidine kinase
L2Z40_06375	COG0352	thiamine-phosphate diphosphorylase activity
L2Z40_06375	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z40_06385	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z40_06415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z40_06445	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z40_06460	COG0358	DNA primase activity
L2Z40_06470	COG0564	pseudouridine synthase activity
L2Z40_06495	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z40_06515	COG0583	DNA-binding transcription factor activity
L2Z40_06520	COG0473	3-isopropylmalate dehydrogenase activity
L2Z40_06530	COG0657	acetylesterase activity
L2Z40_06540	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_06560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z40_06560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z40_06575	COG1981	membrane
L2Z40_06620	COG0456	acetyltransferase
L2Z40_06630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z40_06635	COG0492	ferredoxin-NADP+ reductase activity
L2Z40_06640	COG1674	ftsk spoiiie
L2Z40_06640	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z40_06645	COG1280	lysine exporter protein (LysE YggA)
L2Z40_06660	COG2894	cell division
L2Z40_06675	COG0204	Acyl-transferase
L2Z40_06680	COG2885	chlorophyll binding
L2Z40_06685	COG0210	DNA helicase
L2Z40_06695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z40_06710	COG0121	glutamine amidotransferase
L2Z40_06730	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z40_06735	COG0735	belongs to the Fur family
L2Z40_06760	COG0420	3'-5' exonuclease activity
L2Z40_06780	COG1090	epimerase
L2Z40_06795	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z40_06805	COG2814	Major facilitator Superfamily
L2Z40_06810	COG0405	Gamma-glutamyltransferase
L2Z40_06820	COG0582	viral genome integration into host DNA
L2Z40_06875	COG0629	single-stranded DNA binding
L2Z40_06910	COG0084	hydrolase, TatD family'
L2Z40_06930	COG0477	Major facilitator Superfamily
L2Z40_06935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z40_06945	COG1595	DNA-templated transcription, initiation
L2Z40_07000	COG0531	amino acid
L2Z40_07005	COG2040	homocysteine
L2Z40_07035	COG1309	transcriptional regulator
L2Z40_07040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_07045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_07055	COG1607	acyl-coa hydrolase
L2Z40_07065	COG0523	cobalamin synthesis protein
L2Z40_07075	COG4681	YaeQ
L2Z40_07085	COG0726	polysaccharide deacetylase
L2Z40_07085	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z40_07090	COG1215	transferase activity, transferring glycosyl groups
L2Z40_07100	COG1024	Enoyl-CoA hydratase
L2Z40_07115	COG1414	Transcriptional regulator
L2Z40_07135	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_07145	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z40_07150	COG2271	Major facilitator Superfamily
L2Z40_07160	COG2267	carboxylic ester hydrolase activity
L2Z40_07165	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_07180	COG0028	Belongs to the TPP enzyme family
L2Z40_07190	COG0477	Major facilitator Superfamily
L2Z40_07195	COG0242	peptide deformylase activity
L2Z40_07200	COG2066	Belongs to the glutaminase family
L2Z40_07205	COG2207	Transcriptional regulator
L2Z40_07210	COG2223	nitrite transmembrane transporter activity
L2Z40_07225	COG0583	DNA-binding transcription factor activity
L2Z40_07230	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_07235	COG2271	Major facilitator Superfamily
L2Z40_07240	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z40_07245	COG3958	Transketolase
L2Z40_07255	COG0306	phosphate transporter
L2Z40_07275	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z40_07320	COG4181	ATPase activity
L2Z40_07325	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z40_07355	COG0583	DNA-binding transcription factor activity
L2Z40_07365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_07370	COG1773	rubredoxin
L2Z40_07420	COG2851	Citrate transporter
L2Z40_07425	COG1253	flavin adenine dinucleotide binding
L2Z40_07465	COG0804	urea catabolic process
L2Z40_07475	COG0830	nickel cation binding
L2Z40_07490	COG0742	ribosomal rna small subunit methyltransferase
L2Z40_07495	COG0768	penicillin binding
L2Z40_07520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z40_07525	COG2878	Part of a membrane complex involved in electron transport
L2Z40_07530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z40_07540	COG3384	dioxygenase
L2Z40_07560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z40_07600	COG0006	proline dipeptidase activity
L2Z40_07605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_07610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_07630	COG1279	arginine transmembrane transporter activity
L2Z40_07635	COG0583	DNA-binding transcription factor activity
L2Z40_07675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z40_07680	COG0741	lytic transglycosylase activity
L2Z40_07680	COG1388	LysM domain
L2Z40_07680	COG0741	lytic transglycosylase activity
L2Z40_07680	COG1388	LysM domain
L2Z40_07690	COG4174	ABC transporter (Permease)
L2Z40_07695	COG4239	(ABC) transporter, permease
L2Z40_07700	COG4172	Belongs to the ABC transporter superfamily
L2Z40_07745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z40_07755	COG4251	negative regulation of phosphorylation
L2Z40_07755	COG2203	Gaf domain
L2Z40_07755	COG3706	GGDEF domain
L2Z40_07755	COG5001	Diguanylate cyclase
L2Z40_07765	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_07765	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z40_07795	COG3209	COG3209 Rhs family protein
L2Z40_07830	COG1113	amino acid transport
L2Z40_07840	COG0531	amino acid
L2Z40_07860	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_07880	COG1113	amino acid transport
L2Z40_07910	COG0697	spore germination
L2Z40_07915	COG2721	sulfolactate sulfo-lyase activity
L2Z40_07920	COG2271	Major facilitator Superfamily
L2Z40_07925	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z40_07935	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_07940	COG2186	Transcriptional regulator
L2Z40_07965	COG1960	acyl-CoA dehydrogenase activity
L2Z40_07975	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_07980	COG1024	Enoyl-CoA hydratase
L2Z40_07985	COG2814	Major facilitator Superfamily
L2Z40_08000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_08045	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L2Z40_08050	COG2072	flavoprotein involved in K transport
L2Z40_08055	COG0300	oxidoreductase activity
L2Z40_08065	COG1309	transcriptional regulator
L2Z40_08070	COG1741	Belongs to the pirin family
L2Z40_08085	COG2072	flavoprotein involved in K transport
L2Z40_08095	COG2252	PERMEase
L2Z40_08100	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z40_08105	COG3038	cytochrome b561
L2Z40_08115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z40_08125	COG0527	aspartate kinase activity
L2Z40_08135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z40_08145	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z40_08160	COG0667	Aldo Keto reductase
L2Z40_08175	COG1765	OsmC-like protein
L2Z40_08190	COG0542	response to heat
L2Z40_08225	COG2885	chlorophyll binding
L2Z40_08235	COG0625	glutathione transferase activity
L2Z40_08240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z40_08260	COG3634	alkyl hydroperoxide reductase activity
L2Z40_08280	COG0450	alkyl hydroperoxide reductase
L2Z40_08285	COG1643	Atp-dependent helicase
L2Z40_08300	COG2814	Major facilitator Superfamily
L2Z40_08305	COG3135	benzoate transporter
L2Z40_08310	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_08315	COG0633	Ferredoxin
L2Z40_08315	COG0543	2 iron, 2 sulfur cluster binding
L2Z40_08325	COG4638	Rieske (2fe-2S)
L2Z40_08335	COG0583	DNA-binding transcription factor activity
L2Z40_08385	COG1570	exodeoxyribonuclease VII activity
L2Z40_08415	COG1280	lysine exporter protein (LysE YggA)
L2Z40_08420	COG1278	Cold shock
L2Z40_08455	COG2814	Major facilitator Superfamily
L2Z40_08525	COG5410	chromosome segregation
L2Z40_08530	COG3567	Phage-associated protein, HI1409 family
L2Z40_08550	COG3566	protein conserved in bacteria
L2Z40_08565	COG5434	Belongs to the glycosyl hydrolase 28 family
L2Z40_08600	COG3676	manually curated
L2Z40_08635	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z40_08645	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z40_08650	COG1137	ATPase activity
L2Z40_08655	COG1538	Outer membrane efflux protein
L2Z40_08685	COG4122	O-methyltransferase activity
L2Z40_08695	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z40_08710	COG1522	sequence-specific DNA binding
L2Z40_08715	COG5006	permease, DMT superfamily
L2Z40_08725	COG1560	Kdo2-lipid A biosynthetic process
L2Z40_08740	COG2814	Major facilitator Superfamily
L2Z40_08760	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z40_08805	COG3209	COG3209 Rhs family protein
L2Z40_08825	COG0583	DNA-binding transcription factor activity
L2Z40_08830	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z40_08850	COG4770	biotin carboxylase activity
L2Z40_08855	COG0038	chloride channel
L2Z40_08880	COG1309	transcriptional regulator
L2Z40_08890	COG1063	alcohol dehydrogenase
L2Z40_08905	COG0439	Biotin carboxylase
L2Z40_08910	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z40_08915	COG1733	regulation of RNA biosynthetic process
L2Z40_08925	COG0864	Transcriptional regulator
L2Z40_08935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z40_08940	COG1116	anion transmembrane transporter activity
L2Z40_09060	COG0590	tRNA wobble adenosine to inosine editing
L2Z40_09065	COG2807	transmembrane transport
L2Z40_09080	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z40_09090	COG0789	Transcriptional regulator
L2Z40_09100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z40_09120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z40_09145	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_09150	COG0531	amino acid
L2Z40_09155	COG1760	l-serine dehydratase
L2Z40_09160	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_09160	COG2030	dehydratase
L2Z40_09165	COG3396	Phenylacetate-CoA oxygenase
L2Z40_09170	COG3460	Phenylacetate-CoA oxygenase
L2Z40_09175	COG3396	Phenylacetate-CoA oxygenase
L2Z40_09180	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z40_09185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_09190	COG1024	Enoyl-CoA hydratase
L2Z40_09195	COG1024	Enoyl-CoA hydratase
L2Z40_09200	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z40_09205	COG0183	Belongs to the thiolase family
L2Z40_09210	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z40_09215	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z40_09225	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z40_09230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2Z40_09235	COG0210	DNA helicase
L2Z40_09270	COG1278	Cold shock
L2Z40_09300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z40_09305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z40_09310	COG2271	Major facilitator Superfamily
L2Z40_09320	COG3038	cytochrome b561
L2Z40_09340	COG2267	carboxylic ester hydrolase activity
L2Z40_09345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_09350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z40_09355	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_09365	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z40_09375	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_09380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z40_09385	COG0583	DNA-binding transcription factor activity
L2Z40_09395	COG1414	Transcriptional regulator
L2Z40_09400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z40_09410	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z40_09415	COG3842	ATPase activity
L2Z40_09430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z40_09435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z40_09440	COG2814	Major facilitator Superfamily
L2Z40_09445	COG1960	acyl-CoA dehydrogenase activity
L2Z40_09450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z40_09460	COG1024	Enoyl-CoA hydratase
L2Z40_09470	COG2814	Major facilitator Superfamily
L2Z40_09480	COG0183	Belongs to the thiolase family
L2Z40_09485	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z40_09490	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_09495	COG1024	Enoyl-CoA hydratase
L2Z40_09500	COG1960	acyl-CoA dehydrogenase activity
L2Z40_09505	COG2814	Major facilitator Superfamily
L2Z40_09510	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z40_09515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z40_09525	COG2814	Major facilitator Superfamily
L2Z40_09535	COG1960	acyl-CoA dehydrogenase activity
L2Z40_09550	COG0583	DNA-binding transcription factor activity
L2Z40_09560	COG4770	biotin carboxylase activity
L2Z40_09565	COG1024	Enoyl-CoA hydratase
L2Z40_09570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z40_09575	COG1960	acyl-CoA dehydrogenase activity
L2Z40_09580	COG1309	transcriptional regulator
L2Z40_09585	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z40_09605	COG0583	DNA-binding transcription factor activity
L2Z40_09655	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_09700	COG0784	Response regulator, receiver
L2Z40_09700	COG2205	protein histidine kinase activity
L2Z40_09720	COG0765	amino acid transport
L2Z40_09725	COG0765	amino acid transport
L2Z40_09730	COG1126	abc transporter atp-binding protein
L2Z40_09735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z40_09740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z40_09755	COG1280	lysine exporter protein (LysE YggA)
L2Z40_09765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z40_09770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z40_09775	COG1045	serine acetyltransferase
L2Z40_09790	COG0583	DNA-binding transcription factor activity
L2Z40_09795	COG0625	glutathione transferase activity
L2Z40_09800	COG0625	glutathione transferase activity
L2Z40_09805	COG0583	DNA-binding transcription factor activity
L2Z40_09815	COG1346	cytolysis
L2Z40_09820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z40_09835	COG2814	Major facilitator Superfamily
L2Z40_09845	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z40_09850	COG3052	prosthetic group binding
L2Z40_09870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z40_09890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z40_09900	COG1294	oxidase, subunit
L2Z40_09905	COG1271	oxidase subunit
L2Z40_09930	COG0477	Major facilitator Superfamily
L2Z40_09940	COG4521	taurine ABC transporter
L2Z40_09945	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z40_09950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z40_09955	COG2175	clavaminate synthase activity
L2Z40_09965	COG1953	Uracil, thiamine, allantoin
L2Z40_09975	COG0583	DNA-binding transcription factor activity
L2Z40_09985	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z40_10000	COG0640	Transcriptional regulator
L2Z40_10005	COG0798	PFAM Bile acid sodium symporter
L2Z40_10010	COG0583	DNA-binding transcription factor activity
L2Z40_10025	COG3634	alkyl hydroperoxide reductase activity
L2Z40_10060	COG1301	dicarboxylic acid transport
L2Z40_10065	COG0436	Aminotransferase
L2Z40_10075	COG0386	Belongs to the glutathione peroxidase family
L2Z40_10115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z40_10140	COG0012	GTP binding
L2Z40_10145	COG2011	ABC-type metal ion transport system permease component
L2Z40_10150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z40_10160	COG1464	Belongs to the NlpA lipoprotein family
L2Z40_10190	COG0765	amino acid transport
L2Z40_10195	COG0765	amino acid transport
L2Z40_10200	COG1126	abc transporter atp-binding protein
L2Z40_10210	COG1522	sequence-specific DNA binding
L2Z40_10225	COG1309	transcriptional regulator
L2Z40_10245	COG0583	DNA-binding transcription factor activity
L2Z40_10255	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z40_10265	COG0697	spore germination
L2Z40_10290	COG3121	Chaperone
L2Z40_10295	COG3539	Fimbrial protein
L2Z40_10320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z40_10320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z40_10345	COG3676	manually curated
L2Z40_10375	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z40_10390	COG2353	YceI-like domain
L2Z40_10400	COG3698	Phosphodiester glycosidase
L2Z40_10415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z40_10420	COG0506	proline dehydrogenase activity
L2Z40_10420	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z40_10420	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z40_10430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z40_10435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z40_10455	COG1132	(ABC) transporter
L2Z40_10460	COG3122	Protein conserved in bacteria
L2Z40_10465	COG3619	membrane
L2Z40_10475	COG0640	Transcriptional regulator
L2Z40_10485	COG2850	peptidyl-arginine hydroxylation
L2Z40_10490	COG0424	maF-like protein
L2Z40_10510	COG0191	fructose-bisphosphate aldolase activity
L2Z40_10515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z40_10530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z40_10540	COG1192	Involved in chromosome partitioning
L2Z40_10545	COG1475	DNA binding
L2Z40_10550	COG0811	peptide transport
L2Z40_10560	COG1132	(ABC) transporter
L2Z40_10565	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z40_10585	COG0084	hydrolase, TatD family'
L2Z40_10650	COG0776	regulation of translation
L2Z40_10680	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z40_10685	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z40_10710	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
L2Z40_10730	COG0339	signal peptide processing
L2Z40_10740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z40_10775	COG0702	epimerase
L2Z40_10780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z40_10800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z40_10830	COG0316	Belongs to the HesB IscA family
L2Z40_10835	COG0822	iron-sulfur transferase activity
L2Z40_10860	COG0776	regulation of translation
L2Z40_10865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z40_10870	COG2207	Transcriptional regulator
L2Z40_10875	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z40_10880	COG1960	acyl-CoA dehydrogenase activity
L2Z40_10885	COG1960	acyl-CoA dehydrogenase activity
L2Z40_10900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z40_10915	COG2814	Major facilitator Superfamily
L2Z40_10920	COG4264	IucA IucC family
L2Z40_10925	COG4264	IucA IucC family
L2Z40_10935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z40_10965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z40_10980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z40_10985	COG0406	alpha-ribazole phosphatase activity
L2Z40_11000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z40_11005	COG0730	response to heat
L2Z40_11025	COG4773	Receptor
L2Z40_11030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z40_11085	COG2226	methyltransferase
L2Z40_11110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z40_11145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z40_11155	COG0133	tryptophan synthase activity
L2Z40_11170	COG3706	GGDEF domain
L2Z40_11185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z40_11190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z40_11195	COG0022	dehydrogenase e1 component
L2Z40_11200	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z40_11205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z40_11215	COG1063	alcohol dehydrogenase
L2Z40_11220	COG3781	membrane
L2Z40_11230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z40_11230	COG3453	Protein conserved in bacteria
L2Z40_11245	COG0730	response to heat
L2Z40_11260	COG2207	Transcriptional regulator
L2Z40_11260	COG3708	Transcriptional regulator
L2Z40_11265	COG1733	regulation of RNA biosynthetic process
L2Z40_11270	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z40_11280	COG2188	Transcriptional regulator
L2Z40_11295	COG4521	taurine ABC transporter
L2Z40_11300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z40_11320	COG0477	Major facilitator Superfamily
L2Z40_11330	COG1027	Aspartate ammonia-lyase
L2Z40_11345	COG0583	DNA-binding transcription factor activity
L2Z40_11350	COG0583	DNA-binding transcription factor activity
L2Z40_11355	COG0183	Belongs to the thiolase family
L2Z40_11360	COG2031	fatty acid transporter
L2Z40_11375	COG0583	DNA-binding transcription factor activity
L2Z40_11385	COG2610	gluconate transmembrane transporter activity
L2Z40_11390	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_11395	COG2207	Transcriptional regulator
L2Z40_11410	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_11420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_11435	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_11435	COG0543	2 iron, 2 sulfur cluster binding
L2Z40_11440	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z40_11445	COG4638	Rieske (2fe-2S)
L2Z40_11455	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z40_11460	COG4149	molybdate abc transporter
L2Z40_11465	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z40_11470	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_11475	COG3433	isochorismatase activity
L2Z40_11475	COG1535	isochorismatase
L2Z40_11540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z40_11555	COG0753	catalase activity
L2Z40_11565	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z40_11590	COG3539	Fimbrial protein
L2Z40_11630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z40_11640	COG2072	flavoprotein involved in K transport
L2Z40_11650	COG1538	Outer membrane efflux protein
L2Z40_11655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z40_11660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_11665	COG0745	RESPONSE REGULATOR receiver
L2Z40_11670	COG2205	protein histidine kinase activity
L2Z40_11680	COG2207	Transcriptional regulator
L2Z40_11695	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_11705	COG1073	alpha beta
L2Z40_11740	COG3676	manually curated
L2Z40_11745	COG0556	nucleotide-excision repair
L2Z40_11760	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z40_11820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z40_11835	COG2084	Dehydrogenase
L2Z40_11845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z40_11850	COG0583	DNA-binding transcription factor activity
L2Z40_11860	COG0129	dihydroxy-acid dehydratase activity
L2Z40_11865	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_11880	COG1566	PFAM secretion protein HlyD family protein
L2Z40_11895	COG0583	DNA-binding transcription factor activity
L2Z40_11910	COG2188	Transcriptional regulator
L2Z40_11970	COG1473	amidohydrolase
L2Z40_11980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z40_11980	COG0475	glutathione-regulated potassium exporter activity
L2Z40_11990	COG0583	DNA-binding transcription factor activity
L2Z40_11995	COG1335	isochorismatase
L2Z40_12015	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_12025	COG4689	acetoacetate decarboxylase
L2Z40_12030	COG4221	oxidoreductase activity
L2Z40_12040	COG1309	transcriptional regulator
L2Z40_12080	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z40_12080	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_12095	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_12115	COG2186	Transcriptional regulator
L2Z40_12125	COG0583	DNA-binding transcription factor activity
L2Z40_12130	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z40_12135	COG4829	muconolactone delta-isomerase
L2Z40_12145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z40_12150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z40_12155	COG0183	Belongs to the thiolase family
L2Z40_12160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z40_12170	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_12180	COG3733	amine oxidase
L2Z40_12190	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_12200	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_12210	COG4638	Rieske (2fe-2S)
L2Z40_12230	COG0154	amidase activity
L2Z40_12240	COG2814	Major facilitator Superfamily
L2Z40_12265	COG1960	acyl-CoA dehydrogenase activity
L2Z40_12270	COG0583	DNA-binding transcription factor activity
L2Z40_12275	COG1414	Transcriptional regulator
L2Z40_12290	COG2391	methyltransferase activity
L2Z40_12300	COG4993	Dehydrogenase
L2Z40_12305	COG3659	wide pore channel activity
L2Z40_12310	COG3420	alginic acid biosynthetic process
L2Z40_12315	COG0710	3-dehydroquinate dehydratase activity
L2Z40_12320	COG3485	protocatechuate 3,4-dioxygenase
L2Z40_12325	COG3485	protocatechuate 3,4-dioxygenase
L2Z40_12330	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z40_12335	COG2271	Major facilitator Superfamily
L2Z40_12340	COG0596	Alpha beta hydrolase
L2Z40_12345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z40_12350	COG0183	Belongs to the thiolase family
L2Z40_12355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z40_12360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z40_12370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z40_12375	COG2323	membrane
L2Z40_12420	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z40_12420	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_12445	COG0542	response to heat
L2Z40_12450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z40_12480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z40_12485	COG0569	domain protein
L2Z40_12490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z40_12505	COG4774	siderophore transport
L2Z40_12510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z40_12520	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z40_12535	COG1294	oxidase, subunit
L2Z40_12540	COG4890	Cyd operon protein YbgT
L2Z40_12550	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z40_12560	COG0552	protein localization to endoplasmic reticulum
L2Z40_12585	COG0516	GMP reductase activity
L2Z40_12585	COG0517	IMP dehydrogenase activity
L2Z40_12590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z40_12595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z40_12605	COG0583	DNA-binding transcription factor activity
L2Z40_12610	COG0024	Methionine aminopeptidase
L2Z40_12640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z40_12640	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z40_12645	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z40_12650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z40_12650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z40_12650	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z40_12685	COG2135	peptidase activity
L2Z40_12690	COG0659	secondary active sulfate transmembrane transporter activity
L2Z40_12710	COG1113	amino acid transport
L2Z40_12745	COG1011	Hydrolase
L2Z40_12750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z40_12760	COG2137	regulation of response to DNA damage stimulus
L2Z40_12775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z40_12810	COG0575	Belongs to the CDS family
L2Z40_12815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z40_12840	COG3852	Histidine kinase
L2Z40_12845	COG2204	response regulator
L2Z40_12900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z40_12905	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z40_12925	COG0697	spore germination
L2Z40_12945	COG0303	'Molybdopterin
L2Z40_12950	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z40_12950	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z40_12965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z40_12970	COG0243	molybdopterin cofactor binding
L2Z40_12980	COG0243	molybdopterin cofactor binding
L2Z40_12985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_12990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_12990	COG2146	nitrite reductase [NAD(P)H] activity
L2Z40_13000	COG0745	RESPONSE REGULATOR receiver
L2Z40_13005	COG1116	anion transmembrane transporter activity
L2Z40_13005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z40_13025	COG0511	ligase activity, forming carbon-carbon bonds
L2Z40_13040	COG2814	Major facilitator Superfamily
L2Z40_13060	COG0069	glutamate synthase activity
L2Z40_13080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z40_13090	COG1454	alcohol dehydrogenase
L2Z40_13095	COG0824	Thioesterase
L2Z40_13105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z40_13120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z40_13125	COG2030	dehydratase
L2Z40_13135	COG0183	Belongs to the thiolase family
L2Z40_13145	COG0583	DNA-binding transcription factor activity
L2Z40_13150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z40_13160	COG1522	sequence-specific DNA binding
L2Z40_13165	COG3135	benzoate transporter
L2Z40_13175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z40_13195	COG0589	response to stress
L2Z40_13200	COG0488	(ABC) transporter
L2Z40_13220	COG4773	Receptor
L2Z40_13250	COG0668	transmembrane transport
L2Z40_13260	COG1309	transcriptional regulator
L2Z40_13275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L2Z40_13290	COG1605	Chorismate mutase
L2Z40_13330	COG0308	aminopeptidase N
L2Z40_13355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z40_13360	COG1454	alcohol dehydrogenase
L2Z40_13380	COG0531	amino acid
L2Z40_13385	COG4303	Ethanolamine ammonia lyase large subunit
L2Z40_13390	COG4302	ethanolamine ammonia-lyase activity
L2Z40_13395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z40_13395	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z40_13400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z40_13425	COG0697	spore germination
L2Z40_13430	COG1923	regulation of RNA biosynthetic process
L2Z40_13440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z40_13445	COG0802	atpase or kinase
L2Z40_13465	COG1187	pseudouridine synthase activity
L2Z40_13480	COG0583	DNA-binding transcription factor activity
L2Z40_13495	COG2814	Major facilitator Superfamily
L2Z40_13500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z40_13525	COG0729	surface antigen
L2Z40_13545	COG0174	glutamine synthetase
L2Z40_13550	COG0745	RESPONSE REGULATOR receiver
L2Z40_13555	COG2205	protein histidine kinase activity
L2Z40_13565	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z40_13570	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z40_13595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z40_13600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z40_13605	COG1960	acyl-CoA dehydrogenase activity
L2Z40_13620	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z40_13625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z40_13645	COG0583	DNA-binding transcription factor activity
L2Z40_13660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z40_13670	COG3658	cytochrome
L2Z40_13675	COG1215	transferase activity, transferring glycosyl groups
L2Z40_13680	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z40_13680	COG0726	polysaccharide deacetylase
L2Z40_13705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z40_13710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z40_13720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z40_13745	COG0305	Participates in initiation and elongation during chromosome replication
L2Z40_13750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z40_13760	COG1305	Transglutaminase-like
L2Z40_13770	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z40_13800	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z40_13805	COG0138	bifunctional purine biosynthesis protein purh
L2Z40_13810	COG0151	Belongs to the GarS family
L2Z40_13815	COG1464	Belongs to the NlpA lipoprotein family
L2Z40_13820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z40_13825	COG2011	ABC-type metal ion transport system permease component
L2Z40_13830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z40_13840	COG3676	manually curated
L2Z40_13845	COG1301	dicarboxylic acid transport
L2Z40_13875	COG1794	racemase activity, acting on amino acids and derivatives
L2Z40_13895	COG0745	RESPONSE REGULATOR receiver
L2Z40_13900	COG0642	Histidine kinase
L2Z40_13905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2Z40_13915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2Z40_13955	COG2351	hydroxyisourate hydrolase activity
L2Z40_13965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z40_13965	COG3008	intermembrane lipid transfer
L2Z40_13970	COG2995	paraquat-inducible protein a
L2Z40_13995	COG0477	Major facilitator Superfamily
L2Z40_14055	COG2186	Transcriptional regulator
L2Z40_14070	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_14080	COG0583	DNA-binding transcription factor activity
L2Z40_14090	COG0786	glutamate:sodium symporter activity
L2Z40_14095	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z40_14120	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z40_14220	COG1610	YqeY-like protein
L2Z40_14225	COG4783	chaperone-mediated protein folding
L2Z40_14250	COG1286	toxin biosynthetic process
L2Z40_14280	COG0778	Nitroreductase
L2Z40_14290	COG0513	Belongs to the DEAD box helicase family
L2Z40_14315	COG2363	Small membrane protein
L2Z40_14340	COG1234	tRNA 3'-trailer cleavage
L2Z40_14345	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z40_14355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z40_14365	COG2819	hydrolase of the alpha beta superfamily
L2Z40_14370	COG1960	acyl-CoA dehydrogenase activity
L2Z40_14375	COG1301	dicarboxylic acid transport
L2Z40_14380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z40_14385	COG3139	Protein of unknown function (DUF1315)
L2Z40_14390	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z40_14395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z40_14405	COG0494	nUDIX hydrolase
L2Z40_14415	COG0642	Histidine kinase
L2Z40_14430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z40_14440	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z40_14455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z40_14460	COG0826	peptidase U32
L2Z40_14465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z40_14480	COG4160	amino acid transport
L2Z40_14485	COG4215	(ABC) transporter
L2Z40_14500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_14605	COG0739	heme binding
L2Z40_14725	COG5410	chromosome segregation
L2Z40_14820	COG0305	Participates in initiation and elongation during chromosome replication
L2Z40_14885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z40_14925	COG0582	viral genome integration into host DNA
L2Z40_14930	COG1131	(ABC) transporter
L2Z40_14935	COG0842	Transport permease protein
L2Z40_14950	COG0772	Belongs to the SEDS family
L2Z40_14955	COG2951	lytic endotransglycosylase activity
L2Z40_14980	COG2207	Transcriptional regulator
L2Z40_14995	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z40_15000	COG0024	Methionine aminopeptidase
L2Z40_15010	COG2223	nitrite transmembrane transporter activity
L2Z40_15020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z40_15025	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z40_15030	COG1960	acyl-CoA dehydrogenase activity
L2Z40_15045	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z40_15050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z40_15055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z40_15075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z40_15080	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z40_15085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z40_15120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z40_15130	COG0174	glutamine synthetase
L2Z40_15145	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z40_15180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z40_15190	COG0302	gtp cyclohydrolase
L2Z40_15205	COG3676	manually curated
L2Z40_15225	COG3739	integral membrane protein
L2Z40_15240	COG1169	isochorismate synthase
L2Z40_15250	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z40_15255	COG1132	(ABC) transporter
L2Z40_15260	COG1132	(ABC) transporter
L2Z40_15270	COG3433	isochorismatase activity
L2Z40_15270	COG1535	isochorismatase
L2Z40_15275	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z40_15280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z40_15290	COG4774	siderophore transport
L2Z40_15295	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z40_15300	COG4604	ABC transporter, ATP-binding protein
L2Z40_15305	COG4605	iron ion homeostasis
L2Z40_15310	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z40_15315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z40_15330	COG2964	Protein conserved in bacteria
L2Z40_15340	COG1741	Belongs to the pirin family
L2Z40_15400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z40_15400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z40_15405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_15415	COG1012	belongs to the aldehyde dehydrogenase family
L2Z40_15425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_15430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z40_15435	COG0006	proline dipeptidase activity
L2Z40_15440	COG0006	proline dipeptidase activity
L2Z40_15445	COG0583	DNA-binding transcription factor activity
L2Z40_15455	COG2879	small protein
L2Z40_15460	COG1966	Carbon starvation protein
L2Z40_15480	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L2Z40_15505	COG1067	ATP-dependent peptidase activity
L2Z40_15510	COG0583	DNA-binding transcription factor activity
L2Z40_15535	COG1686	Belongs to the peptidase S11 family
L2Z40_15540	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z40_15575	COG0616	signal peptide processing
L2Z40_15580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z40_15590	COG0573	inorganic phosphate transmembrane transporter activity
L2Z40_15595	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z40_15600	COG1113	amino acid transport
L2Z40_15605	COG3961	Belongs to the TPP enzyme family
L2Z40_15610	COG1522	sequence-specific DNA binding
L2Z40_15620	COG0076	glutamate decarboxylase activity
L2Z40_15625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z40_15635	COG1309	transcriptional regulator
L2Z40_15650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z40_15685	COG0352	thiamine-phosphate diphosphorylase activity
L2Z40_15710	COG1203	CRISPR-associated helicase, Cas3
L2Z40_15740	COG0612	Peptidase, M16
L2Z40_15750	COG1823	symporter activity
L2Z40_15755	COG0583	DNA-binding transcription factor activity
L2Z40_15760	COG0477	Major facilitator Superfamily
L2Z40_15780	COG1187	pseudouridine synthase activity
L2Z40_15795	COG1686	Belongs to the peptidase S11 family
L2Z40_15800	COG1252	NADH dehydrogenase
L2Z40_15810	COG0415	Belongs to the DNA photolyase family
L2Z40_15825	COG1215	transferase activity, transferring glycosyl groups
L2Z40_15855	COG2070	2-Nitropropane dioxygenase
L2Z40_15910	COG0556	nucleotide-excision repair
L2Z40_15935	COG0436	Aminotransferase
L2Z40_15965	COG4221	oxidoreductase activity
L2Z40_15975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z40_15980	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z40_15990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z40_16005	COG0681	Belongs to the peptidase S26 family
L2Z40_16020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z40_16040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z40_16045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z40_16050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z40_16060	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z40_16065	COG4208	sulfate ABC transporter
L2Z40_16070	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z40_16075	COG0583	DNA-binding transcription factor activity
L2Z40_16080	COG4625	pathogenesis
L2Z40_16095	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z40_16110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z40_16120	COG1056	cytidyltransferase-related domain
L2Z40_16120	COG1051	belongs to the nudix hydrolase family
L2Z40_16125	COG1024	Enoyl-CoA hydratase
L2Z40_16135	COG2814	Major facilitator Superfamily
L2Z40_16140	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z40_16140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z40_16160	COG1473	amidohydrolase
L2Z40_16165	COG0824	Thioesterase
L2Z40_16185	COG0823	Involved in the tonB-independent uptake of proteins
L2Z40_16205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z40_16240	COG0628	permease
L2Z40_16250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z40_16255	COG0596	Alpha beta hydrolase
L2Z40_16260	COG0616	signal peptide processing
L2Z40_16260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z40_16270	COG2333	competence protein COMEC
L2Z40_16270	COG0658	competence protein
L2Z40_16275	COG1136	(ABC) transporter
L2Z40_16280	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z40_16315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_16335	COG0463	Glycosyl transferase, family 2
L2Z40_16365	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z40_16370	COG1280	lysine exporter protein (LysE YggA)
L2Z40_16380	COG0019	diaminopimelate decarboxylase activity
L2Z40_16390	COG1113	amino acid transport
L2Z40_16405	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z40_16415	COG3339	Conserved Protein
L2Z40_16420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z40_16425	COG0243	molybdopterin cofactor binding
L2Z40_16430	COG1929	Belongs to the glycerate kinase type-1 family
L2Z40_16445	COG0778	Nitroreductase
L2Z40_16475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z40_16490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z40_16510	COG0741	lytic transglycosylase activity
L2Z40_16530	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z40_16535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z40_16560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z40_16565	COG1597	lipid kinase activity
L2Z40_16580	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z40_16585	COG0477	Major facilitator Superfamily
L2Z40_16635	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z40_16640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z40_16665	COG0505	Belongs to the CarA family
L2Z40_16685	COG0589	response to stress
L2Z40_16700	COG2843	Capsule synthesis protein
L2Z40_16730	COG2321	neutral zinc metallopeptidase
L2Z40_16735	COG2354	Protein conserved in bacteria
L2Z40_16765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z40_16790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z40_16795	COG1053	succinate dehydrogenase
L2Z40_16800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z40_16805	COG2009	succinate dehydrogenase
L2Z40_16840	COG2921	Belongs to the UPF0250 family
L2Z40_16845	COG0321	lipoyl(octanoyl) transferase activity
L2Z40_16860	COG0531	amino acid
L2Z40_16870	COG1733	regulation of RNA biosynthetic process
L2Z40_16875	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z40_16880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z40_16880	COG1648	precorrin-2 dehydrogenase activity
L2Z40_16895	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z40_16925	COG3676	manually curated
L2Z40_16930	COG0671	phosphoesterase, PA-phosphatase related
L2Z40_16935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_16945	COG1538	Outer membrane efflux protein
L2Z40_16950	COG0393	Putative heavy-metal-binding
L2Z40_16955	COG0393	Putative heavy-metal-binding
L2Z40_16965	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z40_16975	COG0525	valine-tRNA ligase activity
L2Z40_16995	COG0583	DNA-binding transcription factor activity
L2Z40_17000	COG0004	ammonium transporteR
L2Z40_17010	COG0642	Histidine kinase
L2Z40_17015	COG0745	RESPONSE REGULATOR receiver
L2Z40_17020	COG2194	sulfuric ester hydrolase activity
L2Z40_17035	COG3676	manually curated
L2Z40_17050	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z40_17065	COG2315	Protein conserved in bacteria
L2Z40_17070	COG0142	geranyltranstransferase activity
L2Z40_17075	COG2828	Protein conserved in bacteria
L2Z40_17080	COG1113	amino acid transport
L2Z40_17100	COG2207	Transcriptional regulator
L2Z40_17125	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z40_17135	COG0560	Phosphoserine phosphatase
L2Z40_17145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z40_17155	COG1530	ribonuclease E activity
L2Z40_17160	COG0424	maF-like protein
L2Z40_17165	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z40_17170	COG1792	Involved in formation and maintenance of cell shape
L2Z40_17175	COG1077	Cell shape determining protein MreB Mrl
L2Z40_17180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z40_17190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z40_17215	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z40_17220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z40_17225	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z40_17230	COG1115	amino acid carrier protein
L2Z40_17250	COG2814	Major facilitator Superfamily
L2Z40_17255	COG1289	transmembrane transporter activity
L2Z40_17265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z40_17305	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z40_17310	COG2832	Protein of unknown function (DUF454)
L2Z40_17320	COG5510	response to toxic substance
L2Z40_17335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z40_17350	COG0840	transmembrane signaling receptor activity
L2Z40_17390	COG3422	double-strand break repair
L2Z40_17395	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z40_17400	COG3189	MarR family transcriptional regulator
L2Z40_17410	COG0354	folic acid binding
L2Z40_17415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z40_17425	COG0679	Auxin Efflux Carrier
L2Z40_17430	COG1902	pentaerythritol trinitrate reductase activity
L2Z40_17435	COG4772	TonB-dependent receptor
L2Z40_17440	COG2094	Belongs to the DNA glycosylase MPG family
L2Z40_17465	COG1217	gtp-binding protein TYPA
L2Z40_17470	COG2233	PERMEase
L2Z40_17480	COG0833	amino acid
L2Z40_17485	COG1690	Belongs to the RtcB family
L2Z40_17495	COG2885	chlorophyll binding
L2Z40_17495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z40_17505	COG0183	Belongs to the thiolase family
L2Z40_17525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z40_17545	COG2207	Transcriptional regulator
L2Z40_17550	COG0183	Belongs to the thiolase family
L2Z40_17570	COG2153	protein acetylation
L2Z40_17580	COG1272	protein, Hemolysin III
L2Z40_17585	COG0477	Major facilitator Superfamily
L2Z40_17600	COG0450	alkyl hydroperoxide reductase
L2Z40_17620	COG0285	dihydrofolate synthase activity
L2Z40_17670	COG2096	Adenosyltransferase
L2Z40_17690	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z40_17695	COG0745	RESPONSE REGULATOR receiver
L2Z40_17700	COG2205	protein histidine kinase activity
L2Z40_17710	COG1960	acyl-CoA dehydrogenase activity
L2Z40_17715	COG1960	acyl-CoA dehydrogenase activity
L2Z40_17790	COG0438	transferase activity, transferring glycosyl groups
L2Z40_17795	COG0463	Glycosyl transferase, family 2
L2Z40_17800	COG0726	polysaccharide deacetylase
L2Z40_17820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z40_17825	COG2205	protein histidine kinase activity
L2Z40_17830	COG4695	Portal protein
L2Z40_17965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2Z40_17975	COG3646	Phage regulatory protein
L2Z40_18020	COG0629	single-stranded DNA binding
L2Z40_18025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z40_18070	COG1862	Preprotein translocase
L2Z40_18085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z40_18095	COG3781	membrane
L2Z40_18100	COG0613	PHP domain protein
L2Z40_18110	COG2350	Protein conserved in bacteria
L2Z40_18140	COG1607	acyl-coa hydrolase
L2Z40_18200	COG2199	diguanylate cyclase activity
L2Z40_18210	COG1408	metallophosphoesterase
L2Z40_18215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z40_18225	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z40_18245	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z40_18250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z40_18265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z40_18275	COG2969	positive regulation of protein catabolic process
L2Z40_18295	COG1960	acyl-CoA dehydrogenase activity
L2Z40_18300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z40_18315	COG1309	transcriptional regulator
L2Z40_18320	COG1960	acyl-CoA dehydrogenase activity
L2Z40_18480	COG1002	Type II restriction enzyme, methylase subunits
L2Z40_18490	COG0659	secondary active sulfate transmembrane transporter activity
L2Z40_18495	COG0589	response to stress
L2Z40_18595	COG3853	Toxic anion resistance protein (TelA)
L2Z40_18615	COG1475	DNA binding
L2Z40_18630	COG1484	DNA-dependent DNA replication
L2Z40_18635	COG2390	Transcriptional regulator
L2Z40_18635	COG4584	PFAM Integrase catalytic
L2Z40_18665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z40_18675	COG3676	manually curated
L2Z40_18740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z40_18820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z40_18855	COG0741	lytic transglycosylase activity
L2Z40_18870	COG2826	transposase and inactivated derivatives, IS30 family
L2Z40_18880	COG2826	transposase and inactivated derivatives, IS30 family