locus-tag	class	description
AXK18_00030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXK18_00045	COG0506	proline dehydrogenase activity
AXK18_00045	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXK18_00045	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXK18_00050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AXK18_00065	COG3698	Phosphodiester glycosidase
AXK18_00075	COG2353	YceI-like domain
AXK18_00085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AXK18_00130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AXK18_00130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AXK18_00155	COG3539	Fimbrial protein
AXK18_00160	COG3121	Chaperone
AXK18_00185	COG0697	spore germination
AXK18_00195	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AXK18_00205	COG0583	DNA-binding transcription factor activity
AXK18_00225	COG1309	transcriptional regulator
AXK18_00240	COG1522	sequence-specific DNA binding
AXK18_00250	COG1126	abc transporter atp-binding protein
AXK18_00255	COG0765	amino acid transport
AXK18_00260	COG0765	amino acid transport
AXK18_00290	COG1464	Belongs to the NlpA lipoprotein family
AXK18_00300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXK18_00305	COG2011	ABC-type metal ion transport system permease component
AXK18_00310	COG0012	GTP binding
AXK18_00335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AXK18_00375	COG0386	Belongs to the glutathione peroxidase family
AXK18_00385	COG0436	Aminotransferase
AXK18_00425	COG3634	alkyl hydroperoxide reductase activity
AXK18_00440	COG0583	DNA-binding transcription factor activity
AXK18_00445	COG0798	PFAM Bile acid sodium symporter
AXK18_00450	COG0640	Transcriptional regulator
AXK18_00465	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AXK18_00485	COG1953	Uracil, thiamine, allantoin
AXK18_00495	COG2175	clavaminate synthase activity
AXK18_00500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXK18_00505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AXK18_00510	COG4521	taurine ABC transporter
AXK18_00520	COG0477	Major facilitator Superfamily
AXK18_00540	COG1271	oxidase subunit
AXK18_00545	COG1294	oxidase, subunit
AXK18_00555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXK18_00575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AXK18_00600	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AXK18_00610	COG2814	Major facilitator Superfamily
AXK18_00630	COG1346	cytolysis
AXK18_00640	COG0583	DNA-binding transcription factor activity
AXK18_00645	COG0625	glutathione transferase activity
AXK18_00650	COG0625	glutathione transferase activity
AXK18_00655	COG0583	DNA-binding transcription factor activity
AXK18_00670	COG1045	serine acetyltransferase
AXK18_00675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXK18_00680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AXK18_00685	COG1280	lysine exporter protein (LysE YggA)
AXK18_00695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXK18_00700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXK18_00705	COG1126	abc transporter atp-binding protein
AXK18_00710	COG0765	amino acid transport
AXK18_00715	COG0765	amino acid transport
AXK18_00730	COG2205	protein histidine kinase activity
AXK18_00730	COG0784	Response regulator, receiver
AXK18_00750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AXK18_00770	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_00820	COG0583	DNA-binding transcription factor activity
AXK18_00840	COG0318	PFAM AMP-dependent synthetase and ligase
AXK18_00845	COG1309	transcriptional regulator
AXK18_00850	COG1960	acyl-CoA dehydrogenase activity
AXK18_00855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXK18_00860	COG1024	Enoyl-CoA hydratase
AXK18_00890	COG1960	acyl-CoA dehydrogenase activity
AXK18_00900	COG2814	Major facilitator Superfamily
AXK18_00910	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AXK18_00915	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AXK18_00920	COG2814	Major facilitator Superfamily
AXK18_00925	COG1960	acyl-CoA dehydrogenase activity
AXK18_00930	COG1024	Enoyl-CoA hydratase
AXK18_00935	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_00940	COG1250	3-hydroxyacyl-CoA dehydrogenase
AXK18_00945	COG0183	Belongs to the thiolase family
AXK18_00955	COG2814	Major facilitator Superfamily
AXK18_00965	COG1024	Enoyl-CoA hydratase
AXK18_00985	COG2814	Major facilitator Superfamily
AXK18_00990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXK18_00995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AXK18_01010	COG3842	ATPase activity
AXK18_01015	COG1840	ABC-type Fe3 transport system, periplasmic component
AXK18_01025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXK18_01030	COG1414	Transcriptional regulator
AXK18_01040	COG0583	DNA-binding transcription factor activity
AXK18_01045	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AXK18_01050	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_01060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AXK18_01065	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_01070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXK18_01075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AXK18_01080	COG2267	carboxylic ester hydrolase activity
AXK18_01100	COG3038	cytochrome b561
AXK18_01105	COG0753	catalase activity
AXK18_01140	COG2050	protein possibly involved in aromatic compounds catabolism
AXK18_01150	COG3327	negative regulation of DNA-templated transcription, initiation
AXK18_01155	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AXK18_01160	COG0183	Belongs to the thiolase family
AXK18_01165	COG1250	3-hydroxyacyl-CoA dehydrogenase
AXK18_01170	COG1024	Enoyl-CoA hydratase
AXK18_01175	COG1024	Enoyl-CoA hydratase
AXK18_01180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXK18_01185	COG2151	metal-sulfur cluster biosynthetic enzyme
AXK18_01190	COG3396	Phenylacetate-CoA oxygenase
AXK18_01195	COG3460	Phenylacetate-CoA oxygenase
AXK18_01200	COG3396	Phenylacetate-CoA oxygenase
AXK18_01205	COG2030	dehydratase
AXK18_01205	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_01210	COG1760	l-serine dehydratase
AXK18_01215	COG0531	amino acid
AXK18_01220	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_01235	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXK18_01265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXK18_01275	COG0789	Transcriptional regulator
AXK18_01295	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AXK18_01310	COG2807	transmembrane transport
AXK18_01315	COG0590	tRNA wobble adenosine to inosine editing
AXK18_01325	COG0583	DNA-binding transcription factor activity
AXK18_01365	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AXK18_01365	COG2885	chlorophyll binding
AXK18_01430	COG1116	anion transmembrane transporter activity
AXK18_01435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AXK18_01445	COG0864	Transcriptional regulator
AXK18_01460	COG1733	regulation of RNA biosynthetic process
AXK18_01465	COG2249	NAD(P)H dehydrogenase (quinone) activity
AXK18_01470	COG0439	Biotin carboxylase
AXK18_01485	COG1063	alcohol dehydrogenase
AXK18_01495	COG1309	transcriptional regulator
AXK18_01520	COG0038	chloride channel
AXK18_01525	COG4770	biotin carboxylase activity
AXK18_01545	COG1914	H( )-stimulated, divalent metal cation uptake system
AXK18_01550	COG0583	DNA-binding transcription factor activity
AXK18_01565	COG3209	COG3209 Rhs family protein
AXK18_01570	COG3501	Rhs element vgr protein
AXK18_01595	COG1250	3-hydroxyacyl-CoA dehydrogenase
AXK18_01625	COG1560	Kdo2-lipid A biosynthetic process
AXK18_01635	COG5006	permease, DMT superfamily
AXK18_01640	COG1522	sequence-specific DNA binding
AXK18_01655	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AXK18_01695	COG1538	Outer membrane efflux protein
AXK18_01700	COG1137	ATPase activity
AXK18_01705	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AXK18_01715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AXK18_01720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AXK18_01720	COG0517	IMP dehydrogenase activity
AXK18_01755	COG1733	regulation of RNA biosynthetic process
AXK18_01760	COG2814	Major facilitator Superfamily
AXK18_01790	COG1278	Cold shock
AXK18_01795	COG1280	lysine exporter protein (LysE YggA)
AXK18_01830	COG1570	exodeoxyribonuclease VII activity
AXK18_01880	COG0583	DNA-binding transcription factor activity
AXK18_01885	COG4638	Rieske (2fe-2S)
AXK18_01890	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AXK18_01895	COG0543	2 iron, 2 sulfur cluster binding
AXK18_01895	COG0633	Ferredoxin
AXK18_01900	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_01905	COG3135	benzoate transporter
AXK18_01910	COG2814	Major facilitator Superfamily
AXK18_01925	COG1643	Atp-dependent helicase
AXK18_01930	COG0450	alkyl hydroperoxide reductase
AXK18_01940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AXK18_01950	COG3634	alkyl hydroperoxide reductase activity
AXK18_01970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AXK18_01975	COG0625	glutathione transferase activity
AXK18_01985	COG2885	chlorophyll binding
AXK18_02035	COG1765	OsmC-like protein
AXK18_02055	COG0667	Aldo Keto reductase
AXK18_02070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AXK18_02080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AXK18_02100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXK18_02110	COG3038	cytochrome b561
AXK18_02115	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AXK18_02120	COG2252	PERMEase
AXK18_02130	COG2072	flavoprotein involved in K transport
AXK18_02145	COG1741	Belongs to the pirin family
AXK18_02150	COG1309	transcriptional regulator
AXK18_02155	COG3316	Transposase and inactivated derivatives
AXK18_02170	COG3316	Transposase and inactivated derivatives
AXK18_02175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AXK18_02185	COG3316	Transposase and inactivated derivatives
AXK18_02200	COG3316	Transposase and inactivated derivatives
AXK18_02215	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXK18_02215	COG1902	pentaerythritol trinitrate reductase activity
AXK18_02225	COG2203	Gaf domain
AXK18_02225	COG5001	Diguanylate cyclase
AXK18_02225	COG4251	negative regulation of phosphorylation
AXK18_02225	COG3706	GGDEF domain
AXK18_02235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AXK18_02255	COG4172	Belongs to the ABC transporter superfamily
AXK18_02260	COG4239	(ABC) transporter, permease
AXK18_02265	COG4174	ABC transporter (Permease)
AXK18_02275	COG0741	lytic transglycosylase activity
AXK18_02275	COG1388	LysM domain
AXK18_02275	COG0741	lytic transglycosylase activity
AXK18_02275	COG1388	LysM domain
AXK18_02280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AXK18_02320	COG0583	DNA-binding transcription factor activity
AXK18_02325	COG1279	arginine transmembrane transporter activity
AXK18_02345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXK18_02350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXK18_02355	COG0006	proline dipeptidase activity
AXK18_02390	COG2194	sulfuric ester hydrolase activity
AXK18_02435	COG0739	heme binding
AXK18_02750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXK18_02775	COG3384	dioxygenase
AXK18_02785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AXK18_02790	COG2878	Part of a membrane complex involved in electron transport
AXK18_02795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AXK18_02815	COG0768	penicillin binding
AXK18_02820	COG0742	ribosomal rna small subunit methyltransferase
AXK18_02835	COG0830	nickel cation binding
AXK18_02885	COG1253	flavin adenine dinucleotide binding
AXK18_02895	COG2851	Citrate transporter
AXK18_02950	COG1773	rubredoxin
AXK18_02955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXK18_02965	COG0583	DNA-binding transcription factor activity
AXK18_02990	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AXK18_02995	COG4181	ATPase activity
AXK18_03040	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AXK18_03060	COG0306	phosphate transporter
AXK18_03070	COG3958	Transketolase
AXK18_03075	COG3959	Transketolase, thiamine diphosphate binding domain
AXK18_03080	COG2271	Major facilitator Superfamily
AXK18_03085	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_03090	COG0583	DNA-binding transcription factor activity
AXK18_03105	COG2223	nitrite transmembrane transporter activity
AXK18_03110	COG2207	Transcriptional regulator
AXK18_03115	COG2066	Belongs to the glutaminase family
AXK18_03120	COG0242	peptide deformylase activity
AXK18_03125	COG0477	Major facilitator Superfamily
AXK18_03135	COG0028	Belongs to the TPP enzyme family
AXK18_03150	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_03155	COG2267	carboxylic ester hydrolase activity
AXK18_03180	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_03200	COG1414	Transcriptional regulator
AXK18_03215	COG1024	Enoyl-CoA hydratase
AXK18_03225	COG1215	transferase activity, transferring glycosyl groups
AXK18_03240	COG4681	YaeQ
AXK18_03250	COG0523	cobalamin synthesis protein
AXK18_03260	COG1607	acyl-coa hydrolase
AXK18_03270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXK18_03275	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXK18_03280	COG1309	transcriptional regulator
AXK18_03305	COG2040	homocysteine
AXK18_03310	COG0531	amino acid
AXK18_03365	COG1595	DNA-templated transcription, initiation
AXK18_03375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXK18_03380	COG0477	Major facilitator Superfamily
AXK18_03400	COG0084	hydrolase, TatD family'
AXK18_03485	COG0582	viral genome integration into host DNA
AXK18_03580	COG0592	DNA-directed DNA polymerase activity
AXK18_03810	COG1484	DNA-dependent DNA replication
AXK18_03900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AXK18_03965	COG0405	Gamma-glutamyltransferase
AXK18_03970	COG2814	Major facilitator Superfamily
AXK18_03980	COG2050	protein possibly involved in aromatic compounds catabolism
AXK18_03995	COG1090	epimerase
AXK18_04015	COG0420	3'-5' exonuclease activity
AXK18_04040	COG0735	belongs to the Fur family
AXK18_04045	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AXK18_04065	COG0121	glutamine amidotransferase
AXK18_04080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXK18_04090	COG0210	DNA helicase
AXK18_04100	COG0204	Acyl-transferase
AXK18_04115	COG2894	cell division
AXK18_04135	COG1280	lysine exporter protein (LysE YggA)
AXK18_04145	COG0492	ferredoxin-NADP+ reductase activity
AXK18_04150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AXK18_04160	COG0456	acetyltransferase
AXK18_04220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AXK18_04220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXK18_04240	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_04260	COG0473	3-isopropylmalate dehydrogenase activity
AXK18_04265	COG0583	DNA-binding transcription factor activity
AXK18_04285	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AXK18_04310	COG0564	pseudouridine synthase activity
AXK18_04320	COG0358	DNA primase activity
AXK18_04335	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AXK18_04365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXK18_04395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXK18_04405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AXK18_04405	COG0352	thiamine-phosphate diphosphorylase activity
AXK18_04405	COG0351	phosphomethylpyrimidine kinase
AXK18_04410	COG1652	LysM domain
AXK18_04435	COG1399	metal-binding, possibly nucleic acid-binding protein
AXK18_04440	COG3101	peptidyl-lysine hydroxylation
AXK18_04445	COG0009	L-threonylcarbamoyladenylate synthase
AXK18_04450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AXK18_04455	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AXK18_04470	COG4106	trans-aconitate 2-methyltransferase activity
AXK18_04485	COG0596	Alpha beta hydrolase
AXK18_04485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXK18_04485	COG2226	methyltransferase
AXK18_04490	COG1877	trehalose-phosphatase activity
AXK18_04495	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AXK18_04500	COG2223	nitrite transmembrane transporter activity
AXK18_04520	COG1196	nuclear chromosome segregation
AXK18_04530	COG0730	response to heat
AXK18_04545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AXK18_04555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AXK18_04610	COG0489	protein tyrosine kinase activity
AXK18_04620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXK18_04620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXK18_04650	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AXK18_04655	COG2081	HI0933 family
AXK18_04665	COG0668	transmembrane transport
AXK18_04685	COG0583	DNA-binding transcription factor activity
AXK18_04705	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXK18_04710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AXK18_04740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AXK18_04775	COG2205	protein histidine kinase activity
AXK18_04780	COG0745	RESPONSE REGULATOR receiver
AXK18_04800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AXK18_04880	COG4993	Dehydrogenase
AXK18_04900	COG0384	phenazine biosynthesis protein PhzF
AXK18_04925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AXK18_04930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AXK18_04940	COG0583	DNA-binding transcription factor activity
AXK18_04960	COG1473	amidohydrolase
AXK18_04970	COG0583	DNA-binding transcription factor activity
AXK18_05000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXK18_05010	COG1960	acyl-CoA dehydrogenase activity
AXK18_05015	COG0583	DNA-binding transcription factor activity
AXK18_05020	COG1063	alcohol dehydrogenase
AXK18_05050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AXK18_05055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AXK18_05060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AXK18_05075	COG3667	copper resistance
AXK18_05080	COG2132	Multicopper oxidase
AXK18_05090	COG0561	phosphatase activity
AXK18_05095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXK18_05120	COG1214	PFAM Peptidase M22, glycoprotease
AXK18_05175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AXK18_05185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AXK18_05190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXK18_05195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXK18_05255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXK18_05265	COG1846	Transcriptional regulator
AXK18_05270	COG1764	response to oxidative stress
AXK18_05330	COG0037	tRNA processing
AXK18_05340	COG0248	Ppx GppA phosphatase
AXK18_05365	COG0072	phenylalanine-tRNA ligase activity
AXK18_05390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AXK18_05405	COG1238	metal cluster binding
AXK18_05410	COG0625	glutathione transferase activity
AXK18_05425	COG0318	PFAM AMP-dependent synthetase and ligase
AXK18_05430	COG3028	Belongs to the UPF0307 family
AXK18_05435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXK18_05455	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AXK18_05460	COG0617	tRNA 3'-terminal CCA addition
AXK18_05465	COG1555	photosystem II stabilization
AXK18_05470	COG3956	TIGRFAM MazG family protein
AXK18_05480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXK18_05505	COG1024	Enoyl-CoA hydratase
AXK18_05510	COG2084	Dehydrogenase
AXK18_05515	COG3622	Belongs to the hyi family
AXK18_05530	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AXK18_05535	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AXK18_05540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AXK18_05545	COG0697	spore germination
AXK18_05555	COG2814	Major facilitator Superfamily
AXK18_05560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AXK18_05570	COG0583	DNA-binding transcription factor activity
AXK18_05575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AXK18_05590	COG0084	hydrolase, TatD family'
AXK18_05605	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AXK18_05635	COG0440	acetolactate synthase activity
AXK18_05640	COG0028	Belongs to the TPP enzyme family
AXK18_05665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXK18_05670	COG1136	(ABC) transporter
AXK18_05670	COG0577	efflux transmembrane transporter activity
AXK18_05675	COG1538	Outer membrane efflux protein
AXK18_05690	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AXK18_05695	COG1162	GTPase activity
AXK18_05705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AXK18_05725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXK18_05730	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_05770	COG2986	histidine ammonia-lyase
AXK18_05785	COG0318	PFAM AMP-dependent synthetase and ligase
AXK18_05795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXK18_05800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXK18_05840	COG1426	Protein conserved in bacteria
AXK18_05890	COG0793	Belongs to the peptidase S41A family
AXK18_05905	COG2267	carboxylic ester hydrolase activity
AXK18_05915	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_05920	COG3265	gluconokinase activity
AXK18_05930	COG0800	Aldolase
AXK18_05950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AXK18_05955	COG0857	belongs to the CobB CobQ family
AXK18_05955	COG0280	phosphate acetyltransferase
AXK18_05960	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AXK18_05960	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AXK18_05980	COG0740	serine-type endopeptidase activity
AXK18_05990	COG4774	siderophore transport
AXK18_06000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXK18_06010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXK18_06010	COG2813	Specifically methylates the guanine in position
AXK18_06110	COG0788	formyltetrahydrofolate deformylase activity
AXK18_06125	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXK18_06130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXK18_06135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AXK18_06135	COG4651	solute:proton antiporter activity
AXK18_06155	COG0724	RNA recognition motif
AXK18_06160	COG0210	DNA helicase
AXK18_06185	COG1733	regulation of RNA biosynthetic process
AXK18_06205	COG1280	lysine exporter protein (LysE YggA)
AXK18_06210	COG1560	Kdo2-lipid A biosynthetic process
AXK18_06220	COG1301	dicarboxylic acid transport
AXK18_06275	COG0473	3-isopropylmalate dehydrogenase activity
AXK18_06340	COG0583	DNA-binding transcription factor activity
AXK18_06350	COG0625	glutathione transferase activity
AXK18_06355	COG2378	regulation of single-species biofilm formation
AXK18_06360	COG0546	phosphoglycolate phosphatase activity
AXK18_06370	COG1530	ribonuclease E activity
AXK18_06390	COG0583	DNA-binding transcription factor activity
AXK18_06395	COG4221	oxidoreductase activity
AXK18_06400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXK18_06410	COG0534	Mate efflux family protein
AXK18_06425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AXK18_06460	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AXK18_06465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXK18_06490	COG0644	oxidoreductase
AXK18_06490	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AXK18_06495	COG0425	Belongs to the sulfur carrier protein TusA family
AXK18_06500	COG4535	Mg2 and Co2 transporter CorC
AXK18_06510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXK18_06530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AXK18_06535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AXK18_06535	COG0475	glutathione-regulated potassium exporter activity
AXK18_06540	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AXK18_06550	COG0484	heat shock protein binding
AXK18_06555	COG0789	Transcriptional regulator
AXK18_06560	COG0598	Magnesium transport protein CorA
AXK18_06580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXK18_06585	COG1074	ATP-dependent DNA helicase activity
AXK18_06610	COG2226	methyltransferase
AXK18_06625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXK18_06630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AXK18_06645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AXK18_06645	COG2111	Na H antiporter
AXK18_06650	COG1006	Multisubunit Na H antiporter MnhC subunit
AXK18_06655	COG0651	ATP synthesis coupled electron transport
AXK18_06665	COG2212	antiporter activity
AXK18_06685	COG0195	Participates in both transcription termination and antitermination
AXK18_06735	COG0237	dephospho-CoA kinase activity
AXK18_06745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXK18_06760	COG0497	DNA recombination
AXK18_06770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXK18_06800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AXK18_06800	COG2169	Transcriptional regulator
AXK18_06805	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXK18_06885	COG0326	Molecular chaperone. Has ATPase activity
AXK18_06900	COG2056	Na+-H+ antiporter family
AXK18_06905	COG0596	Alpha beta hydrolase
AXK18_07000	COG0546	phosphoglycolate phosphatase activity
AXK18_07005	COG1716	ATPase activity
AXK18_07050	COG0181	hydroxymethylbilane synthase activity
AXK18_07060	COG3275	phosphorelay sensor kinase activity
AXK18_07080	COG1538	Outer membrane efflux protein
AXK18_07085	COG0697	spore germination
AXK18_07110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AXK18_07115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AXK18_07120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXK18_07125	COG0772	Belongs to the SEDS family
AXK18_07150	COG4974	Belongs to the 'phage' integrase family
AXK18_07155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXK18_07165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AXK18_07175	COG2197	response regulator
AXK18_07190	COG0793	Belongs to the peptidase S41A family
AXK18_07195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AXK18_07200	COG0795	lipopolysaccharide-transporting ATPase activity
AXK18_07240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXK18_07240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXK18_07250	COG0004	ammonium transporteR
AXK18_07255	COG0347	Belongs to the P(II) protein family
AXK18_07335	COG1061	Type III restriction enzyme res subunit
AXK18_07355	COG0659	secondary active sulfate transmembrane transporter activity
AXK18_07360	COG0589	response to stress
AXK18_07400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXK18_07450	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AXK18_07500	COG1061	Type III restriction enzyme res subunit
AXK18_07520	COG0659	secondary active sulfate transmembrane transporter activity
AXK18_07525	COG0589	response to stress
AXK18_07570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXK18_07585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AXK18_07600	COG0318	PFAM AMP-dependent synthetase and ligase
AXK18_07610	COG0477	Major facilitator Superfamily
AXK18_07615	COG2860	membrane
AXK18_07625	COG1253	flavin adenine dinucleotide binding
AXK18_07645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXK18_07680	COG0655	NAD(P)H dehydrogenase (quinone) activity
AXK18_07690	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AXK18_07725	COG1309	transcriptional regulator
AXK18_07760	COG0758	DNA mediated transformation
AXK18_07770	COG0697	spore germination
AXK18_07775	COG1309	transcriptional regulator
AXK18_07790	COG0386	Belongs to the glutathione peroxidase family
AXK18_07855	COG1121	(ABC) transporter
AXK18_07860	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AXK18_07865	COG1280	lysine exporter protein (LysE YggA)
AXK18_07870	COG2837	iron assimilation
AXK18_07880	COG0281	malic enzyme
AXK18_07925	COG0519	Catalyzes the synthesis of GMP from XMP
AXK18_07925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXK18_07930	COG4399	Belongs to the UPF0754 family
AXK18_07935	COG2259	Doxx family
AXK18_07940	COG0586	Pfam SNARE associated Golgi protein
AXK18_07955	COG1192	Involved in chromosome partitioning
AXK18_07965	COG0271	Belongs to the BolA IbaG family
AXK18_07985	COG2267	carboxylic ester hydrolase activity
AXK18_08000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AXK18_08010	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AXK18_08010	COG3321	synthase
AXK18_08010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AXK18_08010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXK18_08015	COG1960	acyl-CoA dehydrogenase activity
AXK18_08025	COG2197	response regulator
AXK18_08035	COG3916	Acyl-homoserine-lactone synthase
AXK18_08040	COG0477	Major facilitator Superfamily
AXK18_08045	COG1024	Enoyl-CoA hydratase
AXK18_08050	COG1024	Enoyl-CoA hydratase
AXK18_08055	COG1960	acyl-CoA dehydrogenase activity
AXK18_08060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AXK18_08080	COG1113	amino acid transport
AXK18_08085	COG1113	amino acid transport
AXK18_08105	COG1522	sequence-specific DNA binding
AXK18_08180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AXK18_08195	COG1802	Transcriptional regulator
AXK18_08200	COG1448	Aminotransferase
AXK18_08205	COG0277	FAD linked oxidase domain protein
AXK18_08215	COG2186	Transcriptional regulator
AXK18_08225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXK18_08250	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AXK18_08265	COG0438	transferase activity, transferring glycosyl groups
AXK18_08275	COG0438	transferase activity, transferring glycosyl groups
AXK18_08280	COG1215	transferase activity, transferring glycosyl groups
AXK18_08320	COG0728	peptidoglycan biosynthetic process
AXK18_08325	COG3023	N-Acetylmuramoyl-L-alanine amidase
AXK18_08380	COG0546	phosphoglycolate phosphatase activity
AXK18_08385	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_08410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXK18_08415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXK18_08420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXK18_08425	COG1116	anion transmembrane transporter activity
AXK18_08430	COG1309	transcriptional regulator
AXK18_08435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AXK18_08445	COG0196	riboflavin kinase activity
AXK18_08450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXK18_08460	COG1047	Peptidyl-prolyl cis-trans
AXK18_08500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AXK18_08525	COG0583	DNA-binding transcription factor activity
AXK18_08555	COG2951	lytic endotransglycosylase activity
AXK18_08560	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AXK18_08575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXK18_08585	COG0671	phosphoesterase, PA-phosphatase related
AXK18_08590	COG0861	Integral membrane protein TerC family
AXK18_08600	COG0754	glutathionylspermidine amidase activity
AXK18_08610	COG0402	S-adenosylhomocysteine deaminase activity
AXK18_08630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXK18_08635	COG1230	cation diffusion facilitator family transporter
AXK18_08650	COG0706	membrane insertase activity
AXK18_08665	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AXK18_08675	COG0592	DNA-directed DNA polymerase activity
AXK18_08685	COG0187	DNA topoisomerase II activity
AXK18_08695	COG0586	Pfam SNARE associated Golgi protein
AXK18_08700	COG0488	(ABC) transporter
AXK18_08730	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AXK18_08735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXK18_08775	COG0733	neurotransmitter:sodium symporter activity
AXK18_08815	COG2233	PERMEase
AXK18_08830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXK18_08865	COG2814	Major facilitator Superfamily
AXK18_08870	COG0656	L-ascorbic acid biosynthetic process
AXK18_08875	COG0583	DNA-binding transcription factor activity
AXK18_08885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXK18_08890	COG1064	alcohol dehydrogenase
AXK18_08895	COG2818	Glycosylase
AXK18_08910	COG1194	a g-specific adenine glycosylase
AXK18_08930	COG2983	Belongs to the UPF0260 family
AXK18_08935	COG2133	pyrroloquinoline quinone binding
AXK18_08940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXK18_08945	COG2116	formate transmembrane transporter activity
AXK18_08965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AXK18_08970	COG1335	isochorismatase
AXK18_08975	COG0385	Bile acid
AXK18_08980	COG0534	Mate efflux family protein
AXK18_08985	COG1683	Conserved Protein
AXK18_09005	COG0625	glutathione transferase activity
AXK18_09015	COG1113	amino acid transport
AXK18_09025	COG0523	cobalamin synthesis protein
AXK18_09035	COG2188	Transcriptional regulator
AXK18_09065	COG0010	Belongs to the arginase family
AXK18_09080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AXK18_09085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXK18_09095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AXK18_09200	COG0534	Mate efflux family protein
AXK18_09205	COG0436	Aminotransferase
AXK18_09210	COG2733	membrane
AXK18_09225	COG2918	glutathione biosynthetic process
AXK18_09235	COG3501	Rhs element vgr protein
AXK18_09255	COG3150	esterase
AXK18_09265	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_09270	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AXK18_09280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AXK18_09290	COG2233	PERMEase
AXK18_09295	COG2351	hydroxyisourate hydrolase activity
AXK18_09330	COG3706	GGDEF domain
AXK18_09345	COG1393	Belongs to the ArsC family
AXK18_09350	COG0708	Exodeoxyribonuclease III
AXK18_09370	COG0189	ligase activity
AXK18_09390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AXK18_09400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AXK18_09415	COG4942	peptidase
AXK18_09425	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXK18_09435	COG2119	membrane
AXK18_09470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AXK18_09490	COG1902	pentaerythritol trinitrate reductase activity
AXK18_09495	COG1519	Transferase
AXK18_09500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AXK18_09505	COG0668	transmembrane transport
AXK18_09515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AXK18_09520	COG1335	isochorismatase
AXK18_09525	COG1522	sequence-specific DNA binding
AXK18_09530	COG3328	transposase activity
AXK18_09555	COG0784	Response regulator, receiver
AXK18_09555	COG2205	protein histidine kinase activity
AXK18_09555	COG2198	Histidine kinase
AXK18_09560	COG3162	membrane
AXK18_09565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXK18_09575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXK18_09585	COG3706	GGDEF domain
AXK18_09595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXK18_09600	COG1309	transcriptional regulator
AXK18_09620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AXK18_09620	COG0351	phosphomethylpyrimidine kinase
AXK18_09620	COG0352	thiamine-phosphate diphosphorylase activity
AXK18_09630	COG2814	Major facilitator Superfamily
AXK18_09645	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AXK18_09655	COG1113	amino acid transport
AXK18_09665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AXK18_09670	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_09680	COG1335	isochorismatase
AXK18_09710	COG2814	Major facilitator Superfamily
AXK18_09715	COG0583	DNA-binding transcription factor activity
AXK18_09735	COG0667	Aldo Keto reductase
AXK18_09765	COG1733	regulation of RNA biosynthetic process
AXK18_09770	COG2249	NAD(P)H dehydrogenase (quinone) activity
AXK18_09835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AXK18_09850	COG2329	Antibiotic biosynthesis monooxygenase
AXK18_09880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXK18_09910	COG0427	acetyl-CoA hydrolase
AXK18_09920	COG0745	RESPONSE REGULATOR receiver
AXK18_09930	COG0659	secondary active sulfate transmembrane transporter activity
AXK18_09935	COG4221	oxidoreductase activity
AXK18_09945	COG0488	(ABC) transporter
AXK18_10025	COG0833	amino acid
AXK18_10070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AXK18_10075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AXK18_10090	COG2226	methyltransferase
AXK18_10140	COG0070	glutamate synthase
AXK18_10140	COG0067	glutamate synthase
AXK18_10140	COG0069	glutamate synthase activity
AXK18_10145	COG0493	'glutamate synthase
AXK18_10155	COG1704	LemA family
AXK18_10160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AXK18_10180	COG3307	-O-antigen
AXK18_10200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AXK18_10210	COG0194	GDP metabolic process
AXK18_10260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AXK18_10280	COG5380	lipid catabolic process
AXK18_10285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AXK18_10310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXK18_10315	COG0277	FAD linked oxidase domain protein
AXK18_10325	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AXK18_10345	COG1289	transmembrane transporter activity
AXK18_10355	COG0628	permease
AXK18_10360	COG1192	Involved in chromosome partitioning
AXK18_10390	COG0833	amino acid
AXK18_10395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AXK18_10410	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_10495	COG0517	IMP dehydrogenase activity
AXK18_10500	COG1983	PspC domain protein
AXK18_10510	COG1960	acyl-CoA dehydrogenase activity
AXK18_10525	COG0408	coproporphyrinogen oxidase activity
AXK18_10545	COG0513	Belongs to the DEAD box helicase family
AXK18_10555	COG1127	ABC transporter
AXK18_10560	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AXK18_10570	COG2854	intermembrane phospholipid transfer
AXK18_10580	COG0598	Magnesium transport protein CorA
AXK18_10590	COG0494	nUDIX hydrolase
AXK18_10595	COG1040	competence protein
AXK18_10600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AXK18_10620	COG1946	Acyl-CoA thioesterase
AXK18_10625	COG1301	dicarboxylic acid transport
AXK18_10640	COG1959	2 iron, 2 sulfur cluster binding
AXK18_10645	COG1017	nitric oxide dioxygenase activity
AXK18_10645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXK18_10650	COG0433	COG0433 Predicted ATPase
AXK18_10655	COG0626	cystathionine gamma-synthase activity
AXK18_10775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXK18_10785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXK18_10810	COG1960	acyl-CoA dehydrogenase activity
AXK18_10815	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AXK18_10845	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AXK18_10850	COG0339	signal peptide processing
AXK18_10855	COG0557	exoribonuclease II activity
AXK18_10900	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXK18_10905	COG2169	Transcriptional regulator
AXK18_10910	COG0697	spore germination
AXK18_10915	COG1295	ribonuclease BN
AXK18_10950	COG1702	phosphate starvation-inducible protein PhoH
AXK18_10960	COG0739	heme binding
AXK18_10960	COG0741	lytic transglycosylase activity
AXK18_10960	COG1196	nuclear chromosome segregation
AXK18_10990	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AXK18_10995	COG1183	phosphatidylcholine synthase activity
AXK18_11040	COG1960	acyl-CoA dehydrogenase activity
AXK18_11045	COG1309	transcriptional regulator
AXK18_11060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXK18_11065	COG1960	acyl-CoA dehydrogenase activity
AXK18_11085	COG2969	positive regulation of protein catabolic process
AXK18_11095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AXK18_11110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AXK18_11115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AXK18_11135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AXK18_11160	COG2199	diguanylate cyclase activity
AXK18_11220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXK18_11220	COG3453	Protein conserved in bacteria
AXK18_11235	COG1607	acyl-coa hydrolase
AXK18_11265	COG2350	Protein conserved in bacteria
AXK18_11275	COG0613	PHP domain protein
AXK18_11290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AXK18_11295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXK18_11305	COG1862	Preprotein translocase
AXK18_11335	COG2205	protein histidine kinase activity
AXK18_11340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AXK18_11360	COG0726	polysaccharide deacetylase
AXK18_11370	COG0438	transferase activity, transferring glycosyl groups
AXK18_11435	COG0625	glutathione transferase activity
AXK18_11440	COG0583	DNA-binding transcription factor activity
AXK18_11445	COG1960	acyl-CoA dehydrogenase activity
AXK18_11450	COG1960	acyl-CoA dehydrogenase activity
AXK18_11460	COG2205	protein histidine kinase activity
AXK18_11465	COG0745	RESPONSE REGULATOR receiver
AXK18_11470	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AXK18_11490	COG2096	Adenosyltransferase
AXK18_11505	COG0133	tryptophan synthase activity
AXK18_11540	COG0285	dihydrofolate synthase activity
AXK18_11560	COG0450	alkyl hydroperoxide reductase
AXK18_11575	COG0477	Major facilitator Superfamily
AXK18_11580	COG1272	protein, Hemolysin III
AXK18_11610	COG0183	Belongs to the thiolase family
AXK18_11615	COG2207	Transcriptional regulator
AXK18_11635	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXK18_11655	COG0183	Belongs to the thiolase family
AXK18_11665	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AXK18_11665	COG2885	chlorophyll binding
AXK18_11675	COG1690	Belongs to the RtcB family
AXK18_11680	COG0833	amino acid
AXK18_11720	COG2094	Belongs to the DNA glycosylase MPG family
AXK18_11745	COG1902	pentaerythritol trinitrate reductase activity
AXK18_11750	COG0679	Auxin Efflux Carrier
AXK18_11760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXK18_11765	COG0354	folic acid binding
AXK18_11775	COG3189	MarR family transcriptional regulator
AXK18_11780	COG2824	Alkylphosphonate utilization operon protein PhnA
AXK18_11785	COG3422	double-strand break repair
AXK18_11825	COG0840	transmembrane signaling receptor activity
AXK18_11845	COG5510	response to toxic substance
AXK18_11855	COG2832	Protein of unknown function (DUF454)
AXK18_11860	COG1376	ErfK ybiS ycfS ynhG family protein
AXK18_11920	COG1289	transmembrane transporter activity
AXK18_11925	COG2814	Major facilitator Superfamily
AXK18_11940	COG1115	amino acid carrier protein
AXK18_11945	COG1752	Esterase of the alpha-beta hydrolase superfamily
AXK18_11950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXK18_11955	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AXK18_11995	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXK18_12005	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXK18_12010	COG1077	Cell shape determining protein MreB Mrl
AXK18_12015	COG1792	Involved in formation and maintenance of cell shape
AXK18_12020	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AXK18_12025	COG0424	maF-like protein
AXK18_12030	COG1530	ribonuclease E activity
AXK18_12040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AXK18_12060	COG2249	NAD(P)H dehydrogenase (quinone) activity
AXK18_12085	COG2207	Transcriptional regulator
AXK18_12110	COG2828	Protein conserved in bacteria
AXK18_12115	COG0142	geranyltranstransferase activity
AXK18_12120	COG2315	Protein conserved in bacteria
AXK18_12135	COG1752	Esterase of the alpha-beta hydrolase superfamily
AXK18_12160	COG0745	RESPONSE REGULATOR receiver
AXK18_12165	COG0642	Histidine kinase
AXK18_12175	COG0004	ammonium transporteR
AXK18_12180	COG0583	DNA-binding transcription factor activity
AXK18_12200	COG0525	valine-tRNA ligase activity
AXK18_12210	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_12220	COG0393	Putative heavy-metal-binding
AXK18_12225	COG0393	Putative heavy-metal-binding
AXK18_12230	COG1538	Outer membrane efflux protein
AXK18_12240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXK18_12245	COG0671	phosphoesterase, PA-phosphatase related
AXK18_12275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AXK18_12290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXK18_12290	COG1648	precorrin-2 dehydrogenase activity
AXK18_12295	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AXK18_12300	COG1733	regulation of RNA biosynthetic process
AXK18_12310	COG0531	amino acid
AXK18_12325	COG0321	lipoyl(octanoyl) transferase activity
AXK18_12330	COG2921	Belongs to the UPF0250 family
AXK18_12370	COG2009	succinate dehydrogenase
AXK18_12375	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AXK18_12380	COG1053	succinate dehydrogenase
AXK18_12385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AXK18_12400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXK18_12420	COG2354	Protein conserved in bacteria
AXK18_12425	COG2321	neutral zinc metallopeptidase
AXK18_12455	COG2843	Capsule synthesis protein
AXK18_12470	COG0589	response to stress
AXK18_12490	COG0505	Belongs to the CarA family
AXK18_12515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXK18_12520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXK18_12570	COG0477	Major facilitator Superfamily
AXK18_12575	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AXK18_12595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AXK18_12625	COG0584	glycerophosphoryl diester phosphodiesterase
AXK18_12645	COG0741	lytic transglycosylase activity
AXK18_12665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AXK18_12680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AXK18_12705	COG0778	Nitroreductase
AXK18_12720	COG1929	Belongs to the glycerate kinase type-1 family
AXK18_12725	COG0243	molybdopterin cofactor binding
AXK18_12730	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AXK18_12735	COG3339	Conserved Protein
AXK18_12745	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AXK18_12760	COG1113	amino acid transport
AXK18_12770	COG0019	diaminopimelate decarboxylase activity
AXK18_12780	COG1280	lysine exporter protein (LysE YggA)
AXK18_12785	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AXK18_12815	COG0463	Glycosyl transferase, family 2
AXK18_12835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXK18_12865	COG4591	ABC-type transport system involved in lipoprotein release permease component
AXK18_12870	COG1136	(ABC) transporter
AXK18_12875	COG2333	competence protein COMEC
AXK18_12875	COG0658	competence protein
AXK18_12885	COG0616	signal peptide processing
AXK18_12885	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AXK18_12890	COG0596	Alpha beta hydrolase
AXK18_12895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AXK18_12905	COG0628	permease
AXK18_12940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXK18_12960	COG0823	Involved in the tonB-independent uptake of proteins
AXK18_12980	COG0824	Thioesterase
AXK18_12985	COG1473	amidohydrolase
AXK18_13010	COG2814	Major facilitator Superfamily
AXK18_13020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXK18_13025	COG1024	Enoyl-CoA hydratase
AXK18_13030	COG1051	belongs to the nudix hydrolase family
AXK18_13030	COG1056	cytidyltransferase-related domain
AXK18_13040	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AXK18_13055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AXK18_13070	COG4625	pathogenesis
AXK18_13075	COG0583	DNA-binding transcription factor activity
AXK18_13080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AXK18_13085	COG4208	sulfate ABC transporter
AXK18_13090	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AXK18_13100	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AXK18_13105	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AXK18_13110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AXK18_13130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXK18_13160	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXK18_13170	COG1381	Involved in DNA repair and RecF pathway recombination
AXK18_13175	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AXK18_13185	COG4221	oxidoreductase activity
AXK18_13230	COG0556	nucleotide-excision repair
AXK18_13285	COG2070	2-Nitropropane dioxygenase
AXK18_13315	COG1215	transferase activity, transferring glycosyl groups
AXK18_13330	COG0415	Belongs to the DNA photolyase family
AXK18_13340	COG1252	NADH dehydrogenase
AXK18_13345	COG1686	Belongs to the peptidase S11 family
AXK18_13360	COG1187	pseudouridine synthase activity
AXK18_13380	COG0477	Major facilitator Superfamily
AXK18_13385	COG0583	DNA-binding transcription factor activity
AXK18_13400	COG0612	Peptidase, M16
AXK18_13425	COG0352	thiamine-phosphate diphosphorylase activity
AXK18_13460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXK18_13485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AXK18_13490	COG0076	glutamate decarboxylase activity
AXK18_13500	COG1522	sequence-specific DNA binding
AXK18_13505	COG3961	Belongs to the TPP enzyme family
AXK18_13510	COG1113	amino acid transport
AXK18_13515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AXK18_13520	COG0573	inorganic phosphate transmembrane transporter activity
AXK18_13530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AXK18_13535	COG0616	signal peptide processing
AXK18_13545	COG3328	transposase activity
AXK18_13575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AXK18_13580	COG1686	Belongs to the peptidase S11 family
AXK18_13605	COG0583	DNA-binding transcription factor activity
AXK18_13610	COG1067	ATP-dependent peptidase activity
AXK18_13660	COG2879	small protein
AXK18_13690	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AXK18_13690	COG2508	Transcriptional regulator
AXK18_13710	COG1113	amino acid transport
AXK18_13715	COG0583	DNA-binding transcription factor activity
AXK18_13720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXK18_13725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AXK18_13740	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXK18_13745	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AXK18_13745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXK18_13780	COG2814	Major facilitator Superfamily
AXK18_13785	COG4948	Mandelate Racemase Muconate Lactonizing
AXK18_13795	COG1309	transcriptional regulator
AXK18_13810	COG1741	Belongs to the pirin family
AXK18_13820	COG2964	Protein conserved in bacteria
AXK18_13835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AXK18_13840	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXK18_13845	COG4605	iron ion homeostasis
AXK18_13850	COG4604	ABC transporter, ATP-binding protein
AXK18_13855	COG4607	ABC-type enterochelin transport system periplasmic component
AXK18_13860	COG4774	siderophore transport
AXK18_13875	COG1021	2,3-dihydroxybenzoate-AMP ligase
AXK18_13880	COG1535	isochorismatase
AXK18_13880	COG3433	isochorismatase activity
AXK18_13895	COG1132	(ABC) transporter
AXK18_13905	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AXK18_13915	COG1169	isochorismate synthase
AXK18_13930	COG3739	integral membrane protein
AXK18_13970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AXK18_14000	COG0308	aminopeptidase N
AXK18_14005	COG0512	Glutamine amidotransferase of anthranilate synthase
AXK18_14015	COG3104	oligopeptide transport
AXK18_14030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AXK18_14065	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AXK18_14070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AXK18_14075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXK18_14095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AXK18_14100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AXK18_14105	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AXK18_14120	COG1960	acyl-CoA dehydrogenase activity
AXK18_14125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AXK18_14130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXK18_14145	COG2223	nitrite transmembrane transporter activity
AXK18_14155	COG0024	Methionine aminopeptidase
AXK18_14160	COG0052	Belongs to the universal ribosomal protein uS2 family
AXK18_14175	COG2207	Transcriptional regulator
AXK18_14200	COG2951	lytic endotransglycosylase activity
AXK18_14205	COG0772	Belongs to the SEDS family
AXK18_14220	COG0842	Transport permease protein
AXK18_14225	COG1131	(ABC) transporter
AXK18_14260	COG1538	Outer membrane efflux protein
AXK18_14270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXK18_14285	COG4215	(ABC) transporter
AXK18_14290	COG4160	amino acid transport
AXK18_14295	COG4598	ABC transporter
AXK18_14305	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AXK18_14315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXK18_14330	COG1720	tRNA m6t6A37 methyltransferase activity
AXK18_14350	COG0745	RESPONSE REGULATOR receiver
AXK18_14355	COG0642	Histidine kinase
AXK18_14375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AXK18_14380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AXK18_14385	COG3139	Protein of unknown function (DUF1315)
AXK18_14390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXK18_14395	COG1301	dicarboxylic acid transport
AXK18_14400	COG1960	acyl-CoA dehydrogenase activity
AXK18_14405	COG2819	hydrolase of the alpha beta superfamily
AXK18_14415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXK18_14425	COG2195	Cleaves the N-terminal amino acid of tripeptides
AXK18_14430	COG1234	tRNA 3'-trailer cleavage
AXK18_14480	COG0513	Belongs to the DEAD box helicase family
AXK18_14490	COG0778	Nitroreductase
AXK18_14520	COG1286	toxin biosynthetic process
AXK18_14545	COG4783	chaperone-mediated protein folding
AXK18_14550	COG1610	YqeY-like protein
AXK18_14555	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AXK18_14655	COG3111	PFAM Bacterial OB fold (BOF) protein
AXK18_14680	COG3243	poly(R)-hydroxyalkanoic acid synthase
AXK18_14685	COG0786	glutamate:sodium symporter activity
AXK18_14695	COG2186	Transcriptional regulator
AXK18_14745	COG0477	Major facilitator Superfamily
AXK18_14750	COG3316	Transposase and inactivated derivatives
AXK18_14765	COG1301	dicarboxylic acid transport
AXK18_14775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXK18_14780	COG2011	ABC-type metal ion transport system permease component
AXK18_14785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AXK18_14790	COG1464	Belongs to the NlpA lipoprotein family
AXK18_14795	COG0151	Belongs to the GarS family
AXK18_14800	COG0138	bifunctional purine biosynthesis protein purh
AXK18_14805	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AXK18_14835	COG2308	Evidence 4 Homologs of previously reported genes of
AXK18_14845	COG1305	Transglutaminase-like
AXK18_14855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AXK18_14860	COG0305	Participates in initiation and elongation during chromosome replication
AXK18_14885	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AXK18_14895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AXK18_14900	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AXK18_14935	COG3658	cytochrome
AXK18_14945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AXK18_14980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXK18_14985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXK18_15000	COG1960	acyl-CoA dehydrogenase activity
AXK18_15005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AXK18_15010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AXK18_15035	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AXK18_15040	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AXK18_15050	COG2205	protein histidine kinase activity
AXK18_15055	COG0745	RESPONSE REGULATOR receiver
AXK18_15060	COG0174	glutamine synthetase
AXK18_15080	COG0729	surface antigen
AXK18_15110	COG2814	Major facilitator Superfamily
AXK18_15140	COG1187	pseudouridine synthase activity
AXK18_15160	COG0802	atpase or kinase
AXK18_15165	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AXK18_15175	COG1923	regulation of RNA biosynthetic process
AXK18_15180	COG0697	spore germination
AXK18_15195	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXK18_15210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXK18_15210	COG0519	Catalyzes the synthesis of GMP from XMP
AXK18_15215	COG4302	ethanolamine ammonia-lyase activity
AXK18_15220	COG4303	Ethanolamine ammonia lyase large subunit
AXK18_15225	COG0531	amino acid
AXK18_15245	COG1454	alcohol dehydrogenase
AXK18_15250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AXK18_15260	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AXK18_15280	COG0308	aminopeptidase N
AXK18_15315	COG1605	Chorismate mutase
AXK18_15330	COG1309	transcriptional regulator
AXK18_15340	COG0668	transmembrane transport
AXK18_15400	COG0488	(ABC) transporter
AXK18_15405	COG0589	response to stress
AXK18_15425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AXK18_15435	COG3135	benzoate transporter
AXK18_15440	COG1522	sequence-specific DNA binding
AXK18_15495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AXK18_15505	COG0824	Thioesterase
AXK18_15510	COG1454	alcohol dehydrogenase
AXK18_15520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXK18_15540	COG0069	glutamate synthase activity
AXK18_15560	COG2814	Major facilitator Superfamily
AXK18_15575	COG0511	ligase activity, forming carbon-carbon bonds
AXK18_15590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AXK18_15590	COG1116	anion transmembrane transporter activity
AXK18_15595	COG0745	RESPONSE REGULATOR receiver
AXK18_15605	COG2146	nitrite reductase [NAD(P)H] activity
AXK18_15605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXK18_15610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AXK18_15615	COG0243	molybdopterin cofactor binding
AXK18_15625	COG0243	molybdopterin cofactor binding
AXK18_15630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AXK18_15645	COG0521	Mo-molybdopterin cofactor biosynthetic process
AXK18_15645	COG0315	cyclic pyranopterin monophosphate synthase activity
AXK18_15650	COG0303	'Molybdopterin
AXK18_15660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AXK18_15685	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AXK18_15690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AXK18_15745	COG2204	response regulator
AXK18_15750	COG3852	Histidine kinase
AXK18_15770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXK18_15775	COG0575	Belongs to the CDS family
AXK18_15810	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXK18_15825	COG2137	regulation of response to DNA damage stimulus
AXK18_15835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AXK18_15840	COG1011	Hydrolase
AXK18_15890	COG0659	secondary active sulfate transmembrane transporter activity
AXK18_15895	COG2135	peptidase activity
AXK18_15910	COG5001	Diguanylate cyclase
AXK18_15910	COG3300	MHYT domain
AXK18_15930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXK18_15930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXK18_15930	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AXK18_15935	COG1105	Belongs to the carbohydrate kinase PfkB family
AXK18_15940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXK18_15940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXK18_15970	COG0024	Methionine aminopeptidase
AXK18_15975	COG0583	DNA-binding transcription factor activity
AXK18_15985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AXK18_15990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXK18_15995	COG0517	IMP dehydrogenase activity
AXK18_15995	COG0516	GMP reductase activity
AXK18_16020	COG0552	protein localization to endoplasmic reticulum
AXK18_16030	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AXK18_16045	COG4890	Cyd operon protein YbgT
AXK18_16050	COG1294	oxidase, subunit
AXK18_16090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AXK18_16095	COG4774	siderophore transport
AXK18_16110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AXK18_16115	COG0569	domain protein
AXK18_16120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AXK18_16150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AXK18_16155	COG0542	response to heat
AXK18_16165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AXK18_16180	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXK18_16180	COG1902	pentaerythritol trinitrate reductase activity
AXK18_16230	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AXK18_16240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AXK18_16245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AXK18_16255	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AXK18_16260	COG0596	Alpha beta hydrolase
AXK18_16265	COG2271	Major facilitator Superfamily
AXK18_16270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AXK18_16275	COG3485	protocatechuate 3,4-dioxygenase
AXK18_16280	COG3485	protocatechuate 3,4-dioxygenase
AXK18_16285	COG0710	3-dehydroquinate dehydratase activity
AXK18_16290	COG3420	alginic acid biosynthetic process
AXK18_16295	COG3659	wide pore channel activity
AXK18_16300	COG4993	Dehydrogenase
AXK18_16310	COG2391	methyltransferase activity
AXK18_16325	COG1414	Transcriptional regulator
AXK18_16330	COG0583	DNA-binding transcription factor activity
AXK18_16335	COG1960	acyl-CoA dehydrogenase activity
AXK18_16360	COG2814	Major facilitator Superfamily
AXK18_16370	COG0154	amidase activity
AXK18_16390	COG4638	Rieske (2fe-2S)
AXK18_16400	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_16410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AXK18_16420	COG3733	amine oxidase
AXK18_16430	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_16440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AXK18_16445	COG0183	Belongs to the thiolase family
AXK18_16450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AXK18_16455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AXK18_16465	COG4829	muconolactone delta-isomerase
AXK18_16470	COG4948	Mandelate Racemase Muconate Lactonizing
AXK18_16475	COG0583	DNA-binding transcription factor activity
AXK18_16485	COG2186	Transcriptional regulator
AXK18_16505	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_16525	COG1960	acyl-CoA dehydrogenase activity
AXK18_16530	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_16535	COG3829	transcription factor binding
AXK18_16545	COG3162	membrane
AXK18_16560	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_16575	COG0753	catalase activity
AXK18_16600	COG1846	Transcriptional regulator
AXK18_16605	COG1902	pentaerythritol trinitrate reductase activity
AXK18_16605	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXK18_16615	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AXK18_16645	COG1309	transcriptional regulator
AXK18_16655	COG1335	isochorismatase
AXK18_16660	COG0583	DNA-binding transcription factor activity
AXK18_16670	COG0475	glutathione-regulated potassium exporter activity
AXK18_16670	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AXK18_16680	COG1473	amidohydrolase
AXK18_16690	COG2831	hemolysin activation secretion protein
AXK18_16740	COG0583	DNA-binding transcription factor activity
AXK18_16765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXK18_16770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AXK18_16790	COG1566	PFAM secretion protein HlyD family protein
AXK18_16805	COG1012	belongs to the aldehyde dehydrogenase family
AXK18_16810	COG0129	dihydroxy-acid dehydratase activity
AXK18_16820	COG0583	DNA-binding transcription factor activity
AXK18_16825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AXK18_16835	COG2084	Dehydrogenase
AXK18_16840	COG2207	Transcriptional regulator
AXK18_16855	COG1064	alcohol dehydrogenase
AXK18_16870	COG1120	ATPase activity
AXK18_16890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXK18_17005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AXK18_17055	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_17070	COG2207	Transcriptional regulator
AXK18_17080	COG2205	protein histidine kinase activity
AXK18_17085	COG0745	RESPONSE REGULATOR receiver
AXK18_17090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXK18_17095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXK18_17100	COG1538	Outer membrane efflux protein
AXK18_17110	COG2072	flavoprotein involved in K transport
AXK18_17130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AXK18_17150	COG3539	Fimbrial protein
AXK18_17185	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AXK18_17195	COG0753	catalase activity
AXK18_17210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AXK18_17270	COG1535	isochorismatase
AXK18_17270	COG3433	isochorismatase activity
AXK18_17275	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_17280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AXK18_17285	COG4149	molybdate abc transporter
AXK18_17290	COG0725	ABC transporter, periplasmic molybdate-binding protein
AXK18_17300	COG4638	Rieske (2fe-2S)
AXK18_17305	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AXK18_17310	COG0543	2 iron, 2 sulfur cluster binding
AXK18_17310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AXK18_17325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AXK18_17335	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_17340	COG0412	Dienelactone hydrolase
AXK18_17350	COG2207	Transcriptional regulator
AXK18_17365	COG1028	Short-chain dehydrogenase reductase Sdr
AXK18_17370	COG2610	gluconate transmembrane transporter activity
AXK18_17380	COG0583	DNA-binding transcription factor activity
AXK18_17390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AXK18_17395	COG2031	fatty acid transporter
AXK18_17400	COG0183	Belongs to the thiolase family
AXK18_17405	COG0583	DNA-binding transcription factor activity
AXK18_17410	COG0583	DNA-binding transcription factor activity
AXK18_17455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AXK18_17460	COG4521	taurine ABC transporter
AXK18_17485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AXK18_17490	COG1733	regulation of RNA biosynthetic process
AXK18_17495	COG3708	Transcriptional regulator
AXK18_17495	COG2207	Transcriptional regulator
AXK18_17510	COG0730	response to heat
AXK18_17520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXK18_17520	COG3453	Protein conserved in bacteria
AXK18_17535	COG1063	alcohol dehydrogenase
AXK18_17545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AXK18_17550	COG0508	dehydrogenase complex catalyzes the overall conversion of
AXK18_17555	COG0022	dehydrogenase e1 component
AXK18_17560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AXK18_17565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AXK18_17580	COG3706	GGDEF domain
AXK18_17595	COG0133	tryptophan synthase activity
AXK18_17605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXK18_17640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXK18_17665	COG2226	methyltransferase
AXK18_17720	COG0842	Transport permease protein
AXK18_17725	COG0842	Transport permease protein
AXK18_17730	COG1131	(ABC) transporter
AXK18_17745	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXK18_17750	COG4773	Receptor
AXK18_17770	COG0730	response to heat
AXK18_17775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AXK18_17795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AXK18_17810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AXK18_17850	COG4264	IucA IucC family
AXK18_17855	COG4264	IucA IucC family
AXK18_17875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AXK18_17890	COG1960	acyl-CoA dehydrogenase activity
AXK18_17895	COG1960	acyl-CoA dehydrogenase activity
AXK18_17900	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AXK18_17905	COG2207	Transcriptional regulator
AXK18_17910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXK18_17915	COG0776	regulation of translation
AXK18_17940	COG0822	iron-sulfur transferase activity
AXK18_17945	COG0316	Belongs to the HesB IscA family
AXK18_17975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AXK18_17995	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AXK18_18000	COG0702	epimerase
AXK18_18035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXK18_18045	COG0339	signal peptide processing
AXK18_18100	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AXK18_18105	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AXK18_18135	COG0776	regulation of translation
AXK18_18155	COG0590	tRNA wobble adenosine to inosine editing
AXK18_18185	COG2165	general secretion pathway protein
AXK18_18200	COG0084	hydrolase, TatD family'
AXK18_18220	COG1663	tetraacyldisaccharide 4'-kinase activity
AXK18_18225	COG1132	(ABC) transporter
AXK18_18235	COG0811	peptide transport
AXK18_18240	COG1475	DNA binding
AXK18_18245	COG1192	Involved in chromosome partitioning
AXK18_18255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AXK18_18270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXK18_18275	COG0191	fructose-bisphosphate aldolase activity
AXK18_18295	COG0424	maF-like protein
AXK18_18300	COG2850	peptidyl-arginine hydroxylation
AXK18_18310	COG0640	Transcriptional regulator
AXK18_18320	COG3619	membrane
AXK18_18325	COG3122	Protein conserved in bacteria
AXK18_18330	COG1132	(ABC) transporter
AXK18_18350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXK18_18355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXK18_18365	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXK18_18365	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AXK18_18365	COG0506	proline dehydrogenase activity
AXK18_18460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AXK18_18550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AXK18_18585	COG0741	lytic transglycosylase activity
AXK18_18615	COG2826	transposase and inactivated derivatives, IS30 family
AXK18_18625	COG2826	transposase and inactivated derivatives, IS30 family
AXK18_18695	COG0484	heat shock protein binding
AXK18_18780	COG3853	Toxic anion resistance protein (TelA)
AXK18_18800	COG1475	DNA binding
AXK18_18865	COG1525	nuclease