locus-tag	class	description
L2Z49_00025	COG0833	amino acid
L2Z49_00070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z49_00075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z49_00090	COG2226	methyltransferase
L2Z49_00140	COG0067	glutamate synthase
L2Z49_00140	COG0069	glutamate synthase activity
L2Z49_00140	COG0070	glutamate synthase
L2Z49_00145	COG0493	'glutamate synthase
L2Z49_00155	COG1704	LemA family
L2Z49_00160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z49_00180	COG3307	-O-antigen
L2Z49_00200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z49_00215	COG0194	GDP metabolic process
L2Z49_00265	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z49_00285	COG5380	lipid catabolic process
L2Z49_00290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z49_00315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z49_00320	COG0277	FAD linked oxidase domain protein
L2Z49_00330	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z49_00335	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z49_00360	COG0628	permease
L2Z49_00365	COG1192	Involved in chromosome partitioning
L2Z49_00395	COG0833	amino acid
L2Z49_00400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z49_00405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z49_00415	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_00455	COG0583	DNA-binding transcription factor activity
L2Z49_00500	COG0517	IMP dehydrogenase activity
L2Z49_00505	COG1983	PspC domain protein
L2Z49_00515	COG1960	acyl-CoA dehydrogenase activity
L2Z49_00530	COG0408	coproporphyrinogen oxidase activity
L2Z49_00550	COG0513	Belongs to the DEAD box helicase family
L2Z49_00560	COG1127	ABC transporter
L2Z49_00565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z49_00575	COG2854	intermembrane phospholipid transfer
L2Z49_00585	COG0598	Magnesium transport protein CorA
L2Z49_00595	COG0494	nUDIX hydrolase
L2Z49_00600	COG1040	competence protein
L2Z49_00605	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z49_00625	COG1946	Acyl-CoA thioesterase
L2Z49_00630	COG1301	dicarboxylic acid transport
L2Z49_00645	COG1959	2 iron, 2 sulfur cluster binding
L2Z49_00650	COG1017	nitric oxide dioxygenase activity
L2Z49_00650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z49_00655	COG0433	COG0433 Predicted ATPase
L2Z49_00660	COG0626	cystathionine gamma-synthase activity
L2Z49_00815	COG1960	acyl-CoA dehydrogenase activity
L2Z49_00820	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z49_00850	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z49_00855	COG0339	signal peptide processing
L2Z49_00860	COG0557	exoribonuclease II activity
L2Z49_00905	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z49_00910	COG2169	Transcriptional regulator
L2Z49_00915	COG0697	spore germination
L2Z49_00920	COG1295	ribonuclease BN
L2Z49_00955	COG1702	phosphate starvation-inducible protein PhoH
L2Z49_00965	COG1196	nuclear chromosome segregation
L2Z49_00965	COG0741	lytic transglycosylase activity
L2Z49_00965	COG0739	heme binding
L2Z49_00995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z49_01000	COG1183	phosphatidylcholine synthase activity
L2Z49_01045	COG1960	acyl-CoA dehydrogenase activity
L2Z49_01050	COG1309	transcriptional regulator
L2Z49_01065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z49_01070	COG1960	acyl-CoA dehydrogenase activity
L2Z49_01090	COG2969	positive regulation of protein catabolic process
L2Z49_01100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z49_01115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z49_01120	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z49_01140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z49_01150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z49_01155	COG1408	metallophosphoesterase
L2Z49_01165	COG2199	diguanylate cyclase activity
L2Z49_01235	COG1607	acyl-coa hydrolase
L2Z49_01265	COG2350	Protein conserved in bacteria
L2Z49_01275	COG0613	PHP domain protein
L2Z49_01280	COG3781	membrane
L2Z49_01290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z49_01295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z49_01305	COG1862	Preprotein translocase
L2Z49_01360	COG2205	protein histidine kinase activity
L2Z49_01365	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z49_01385	COG0726	polysaccharide deacetylase
L2Z49_01390	COG0463	Glycosyl transferase, family 2
L2Z49_01395	COG0438	transferase activity, transferring glycosyl groups
L2Z49_01475	COG0583	DNA-binding transcription factor activity
L2Z49_01480	COG1960	acyl-CoA dehydrogenase activity
L2Z49_01485	COG1960	acyl-CoA dehydrogenase activity
L2Z49_01495	COG2205	protein histidine kinase activity
L2Z49_01500	COG0745	RESPONSE REGULATOR receiver
L2Z49_01505	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z49_01525	COG2096	Adenosyltransferase
L2Z49_01575	COG0285	dihydrofolate synthase activity
L2Z49_01595	COG0450	alkyl hydroperoxide reductase
L2Z49_01610	COG0477	Major facilitator Superfamily
L2Z49_01615	COG1272	protein, Hemolysin III
L2Z49_01645	COG0183	Belongs to the thiolase family
L2Z49_01650	COG2207	Transcriptional regulator
L2Z49_01670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z49_01690	COG0183	Belongs to the thiolase family
L2Z49_01705	COG1002	Type II restriction enzyme, methylase subunits
L2Z49_01710	COG1061	Type III restriction enzyme res subunit
L2Z49_01735	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z49_01735	COG2885	chlorophyll binding
L2Z49_01745	COG1690	Belongs to the RtcB family
L2Z49_01750	COG0833	amino acid
L2Z49_01760	COG2233	PERMEase
L2Z49_01765	COG1217	gtp-binding protein TYPA
L2Z49_01790	COG2094	Belongs to the DNA glycosylase MPG family
L2Z49_01795	COG4772	TonB-dependent receptor
L2Z49_01800	COG1902	pentaerythritol trinitrate reductase activity
L2Z49_01815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z49_01820	COG0354	folic acid binding
L2Z49_01830	COG3189	MarR family transcriptional regulator
L2Z49_01835	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z49_01840	COG3422	double-strand break repair
L2Z49_01880	COG0840	transmembrane signaling receptor activity
L2Z49_01900	COG5510	response to toxic substance
L2Z49_01910	COG2832	Protein of unknown function (DUF454)
L2Z49_01915	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z49_01955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z49_01965	COG1289	transmembrane transporter activity
L2Z49_01970	COG2814	Major facilitator Superfamily
L2Z49_01990	COG1115	amino acid carrier protein
L2Z49_01995	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z49_02000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z49_02005	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z49_02035	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z49_02045	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z49_02050	COG1077	Cell shape determining protein MreB Mrl
L2Z49_02055	COG1792	Involved in formation and maintenance of cell shape
L2Z49_02060	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z49_02065	COG0424	maF-like protein
L2Z49_02070	COG1530	ribonuclease E activity
L2Z49_02080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z49_02090	COG0560	Phosphoserine phosphatase
L2Z49_02100	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z49_02125	COG2207	Transcriptional regulator
L2Z49_02145	COG1113	amino acid transport
L2Z49_02150	COG2828	Protein conserved in bacteria
L2Z49_02155	COG0142	geranyltranstransferase activity
L2Z49_02160	COG2315	Protein conserved in bacteria
L2Z49_02175	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z49_02195	COG2194	sulfuric ester hydrolase activity
L2Z49_02200	COG0745	RESPONSE REGULATOR receiver
L2Z49_02205	COG0642	Histidine kinase
L2Z49_02215	COG0004	ammonium transporteR
L2Z49_02220	COG0583	DNA-binding transcription factor activity
L2Z49_02240	COG0525	valine-tRNA ligase activity
L2Z49_02250	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_02260	COG0393	Putative heavy-metal-binding
L2Z49_02265	COG0393	Putative heavy-metal-binding
L2Z49_02270	COG1538	Outer membrane efflux protein
L2Z49_02280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z49_02285	COG0671	phosphoesterase, PA-phosphatase related
L2Z49_02315	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z49_02330	COG1648	precorrin-2 dehydrogenase activity
L2Z49_02330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z49_02335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z49_02340	COG1733	regulation of RNA biosynthetic process
L2Z49_02350	COG0531	amino acid
L2Z49_02365	COG0321	lipoyl(octanoyl) transferase activity
L2Z49_02370	COG2921	Belongs to the UPF0250 family
L2Z49_02410	COG2009	succinate dehydrogenase
L2Z49_02415	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z49_02420	COG1053	succinate dehydrogenase
L2Z49_02425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z49_02450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z49_02470	COG2354	Protein conserved in bacteria
L2Z49_02475	COG2321	neutral zinc metallopeptidase
L2Z49_02495	COG2843	Capsule synthesis protein
L2Z49_02510	COG0589	response to stress
L2Z49_02530	COG0505	Belongs to the CarA family
L2Z49_02555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z49_02560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z49_02610	COG0477	Major facilitator Superfamily
L2Z49_02615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z49_02630	COG1597	lipid kinase activity
L2Z49_02635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z49_02660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z49_02665	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z49_02685	COG0741	lytic transglycosylase activity
L2Z49_02705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z49_02720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z49_02750	COG0778	Nitroreductase
L2Z49_02765	COG1929	Belongs to the glycerate kinase type-1 family
L2Z49_02770	COG0243	molybdopterin cofactor binding
L2Z49_02775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z49_02780	COG3339	Conserved Protein
L2Z49_02790	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z49_02805	COG1113	amino acid transport
L2Z49_02815	COG0019	diaminopimelate decarboxylase activity
L2Z49_02825	COG1280	lysine exporter protein (LysE YggA)
L2Z49_02830	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z49_02860	COG0463	Glycosyl transferase, family 2
L2Z49_02880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z49_02915	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z49_02920	COG1136	(ABC) transporter
L2Z49_02925	COG2333	competence protein COMEC
L2Z49_02925	COG0658	competence protein
L2Z49_02935	COG0616	signal peptide processing
L2Z49_02935	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z49_02940	COG0596	Alpha beta hydrolase
L2Z49_02945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z49_02955	COG0628	permease
L2Z49_02990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z49_03010	COG0823	Involved in the tonB-independent uptake of proteins
L2Z49_03030	COG0824	Thioesterase
L2Z49_03035	COG1473	amidohydrolase
L2Z49_03055	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z49_03055	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z49_03060	COG2814	Major facilitator Superfamily
L2Z49_03070	COG1024	Enoyl-CoA hydratase
L2Z49_03075	COG1051	belongs to the nudix hydrolase family
L2Z49_03075	COG1056	cytidyltransferase-related domain
L2Z49_03085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z49_03100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z49_03115	COG4625	pathogenesis
L2Z49_03120	COG0583	DNA-binding transcription factor activity
L2Z49_03125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z49_03130	COG4208	sulfate ABC transporter
L2Z49_03135	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z49_03145	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z49_03150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z49_03155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z49_03175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z49_03190	COG0681	Belongs to the peptidase S26 family
L2Z49_03205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z49_03215	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z49_03220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z49_03230	COG4221	oxidoreductase activity
L2Z49_03260	COG0436	Aminotransferase
L2Z49_03280	COG0556	nucleotide-excision repair
L2Z49_03335	COG2070	2-Nitropropane dioxygenase
L2Z49_03365	COG1215	transferase activity, transferring glycosyl groups
L2Z49_03380	COG0415	Belongs to the DNA photolyase family
L2Z49_03390	COG1252	NADH dehydrogenase
L2Z49_03395	COG1686	Belongs to the peptidase S11 family
L2Z49_03410	COG1187	pseudouridine synthase activity
L2Z49_03435	COG0477	Major facilitator Superfamily
L2Z49_03440	COG0583	DNA-binding transcription factor activity
L2Z49_03445	COG1823	symporter activity
L2Z49_03455	COG0612	Peptidase, M16
L2Z49_03480	COG0352	thiamine-phosphate diphosphorylase activity
L2Z49_03515	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z49_03530	COG1309	transcriptional regulator
L2Z49_03540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z49_03545	COG0076	glutamate decarboxylase activity
L2Z49_03555	COG1522	sequence-specific DNA binding
L2Z49_03560	COG3961	Belongs to the TPP enzyme family
L2Z49_03565	COG1113	amino acid transport
L2Z49_03570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z49_03575	COG0573	inorganic phosphate transmembrane transporter activity
L2Z49_03585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z49_03590	COG0616	signal peptide processing
L2Z49_03625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z49_03630	COG1686	Belongs to the peptidase S11 family
L2Z49_03655	COG0583	DNA-binding transcription factor activity
L2Z49_03660	COG1067	ATP-dependent peptidase activity
L2Z49_03705	COG1966	Carbon starvation protein
L2Z49_03710	COG2879	small protein
L2Z49_03745	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2Z49_03745	COG2508	Transcriptional regulator
L2Z49_03765	COG1113	amino acid transport
L2Z49_03770	COG0583	DNA-binding transcription factor activity
L2Z49_03775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z49_03780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z49_03790	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_03800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z49_03805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z49_03805	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z49_03840	COG2814	Major facilitator Superfamily
L2Z49_03845	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z49_03855	COG1309	transcriptional regulator
L2Z49_03875	COG1741	Belongs to the pirin family
L2Z49_03885	COG2964	Protein conserved in bacteria
L2Z49_03900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z49_03905	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z49_03910	COG4605	iron ion homeostasis
L2Z49_03915	COG4604	ABC transporter, ATP-binding protein
L2Z49_03920	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z49_03925	COG4774	siderophore transport
L2Z49_03935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z49_03940	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z49_03945	COG3433	isochorismatase activity
L2Z49_03945	COG1535	isochorismatase
L2Z49_03955	COG1132	(ABC) transporter
L2Z49_03960	COG1132	(ABC) transporter
L2Z49_03965	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z49_03975	COG1169	isochorismate synthase
L2Z49_03990	COG3739	integral membrane protein
L2Z49_04015	COG0302	gtp cyclohydrolase
L2Z49_04025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z49_04055	COG0308	aminopeptidase N
L2Z49_04060	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z49_04240	COG5410	chromosome segregation
L2Z49_04330	COG1598	PFAM Uncharacterised protein family UPF0150
L2Z49_04425	COG0582	viral genome integration into host DNA
L2Z49_04440	COG0174	glutamine synthetase
L2Z49_04450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z49_04485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z49_04490	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z49_04495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z49_04515	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z49_04520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z49_04525	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z49_04540	COG1960	acyl-CoA dehydrogenase activity
L2Z49_04545	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z49_04550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z49_04560	COG2223	nitrite transmembrane transporter activity
L2Z49_04570	COG0024	Methionine aminopeptidase
L2Z49_04575	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z49_04590	COG2207	Transcriptional regulator
L2Z49_04615	COG2951	lytic endotransglycosylase activity
L2Z49_04620	COG0772	Belongs to the SEDS family
L2Z49_04635	COG0842	Transport permease protein
L2Z49_04640	COG1131	(ABC) transporter
L2Z49_04685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z49_04700	COG4215	(ABC) transporter
L2Z49_04705	COG4160	amino acid transport
L2Z49_04710	COG4598	ABC transporter
L2Z49_04720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z49_04725	COG0826	peptidase U32
L2Z49_04730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z49_04745	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z49_04755	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z49_04770	COG0642	Histidine kinase
L2Z49_04780	COG0494	nUDIX hydrolase
L2Z49_04790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z49_04795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z49_04800	COG3139	Protein of unknown function (DUF1315)
L2Z49_04805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z49_04810	COG1301	dicarboxylic acid transport
L2Z49_04815	COG1960	acyl-CoA dehydrogenase activity
L2Z49_04820	COG2819	hydrolase of the alpha beta superfamily
L2Z49_04830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z49_04840	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z49_04845	COG1234	tRNA 3'-trailer cleavage
L2Z49_04875	COG2363	Small membrane protein
L2Z49_04900	COG0513	Belongs to the DEAD box helicase family
L2Z49_04910	COG0778	Nitroreductase
L2Z49_04940	COG1286	toxin biosynthetic process
L2Z49_04965	COG4783	chaperone-mediated protein folding
L2Z49_04970	COG1610	YqeY-like protein
L2Z49_05070	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z49_05095	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z49_05100	COG0786	glutamate:sodium symporter activity
L2Z49_05110	COG2186	Transcriptional regulator
L2Z49_05160	COG0477	Major facilitator Superfamily
L2Z49_05190	COG2985	domain, Protein
L2Z49_05200	COG2995	paraquat-inducible protein a
L2Z49_05205	COG3008	intermembrane lipid transfer
L2Z49_05205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z49_05215	COG1794	racemase activity, acting on amino acids and derivatives
L2Z49_05245	COG1301	dicarboxylic acid transport
L2Z49_05255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z49_05260	COG2011	ABC-type metal ion transport system permease component
L2Z49_05265	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z49_05270	COG1464	Belongs to the NlpA lipoprotein family
L2Z49_05275	COG0151	Belongs to the GarS family
L2Z49_05280	COG0138	bifunctional purine biosynthesis protein purh
L2Z49_05285	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z49_05315	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z49_05325	COG1305	Transglutaminase-like
L2Z49_05335	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z49_05340	COG0305	Participates in initiation and elongation during chromosome replication
L2Z49_05365	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z49_05375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z49_05380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z49_05405	COG0726	polysaccharide deacetylase
L2Z49_05405	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z49_05410	COG1215	transferase activity, transferring glycosyl groups
L2Z49_05415	COG3658	cytochrome
L2Z49_05425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z49_05440	COG0583	DNA-binding transcription factor activity
L2Z49_05460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z49_05465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z49_05480	COG1960	acyl-CoA dehydrogenase activity
L2Z49_05485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z49_05490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z49_05515	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z49_05520	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z49_05530	COG2205	protein histidine kinase activity
L2Z49_05535	COG0745	RESPONSE REGULATOR receiver
L2Z49_05540	COG0174	glutamine synthetase
L2Z49_05560	COG0729	surface antigen
L2Z49_05585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z49_05590	COG2814	Major facilitator Superfamily
L2Z49_05605	COG0583	DNA-binding transcription factor activity
L2Z49_05620	COG1187	pseudouridine synthase activity
L2Z49_05640	COG0802	atpase or kinase
L2Z49_05645	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z49_05655	COG1923	regulation of RNA biosynthetic process
L2Z49_05660	COG0697	spore germination
L2Z49_05675	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z49_05685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z49_05690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z49_05690	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z49_05695	COG4302	ethanolamine ammonia-lyase activity
L2Z49_05700	COG4303	Ethanolamine ammonia lyase large subunit
L2Z49_05705	COG0531	amino acid
L2Z49_05725	COG1454	alcohol dehydrogenase
L2Z49_05730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z49_05740	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z49_05765	COG0308	aminopeptidase N
L2Z49_05775	COG4221	oxidoreductase activity
L2Z49_05785	COG1605	Chorismate mutase
L2Z49_05805	COG1309	transcriptional regulator
L2Z49_05815	COG0668	transmembrane transport
L2Z49_05845	COG4773	Receptor
L2Z49_05865	COG0488	(ABC) transporter
L2Z49_05870	COG0589	response to stress
L2Z49_05895	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z49_05905	COG3135	benzoate transporter
L2Z49_05910	COG1522	sequence-specific DNA binding
L2Z49_05920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z49_05925	COG0583	DNA-binding transcription factor activity
L2Z49_05935	COG0183	Belongs to the thiolase family
L2Z49_05945	COG2030	dehydratase
L2Z49_05950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z49_05965	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z49_05975	COG0824	Thioesterase
L2Z49_05980	COG1454	alcohol dehydrogenase
L2Z49_05990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z49_06010	COG0069	glutamate synthase activity
L2Z49_06345	COG2814	Major facilitator Superfamily
L2Z49_06360	COG0511	ligase activity, forming carbon-carbon bonds
L2Z49_06380	COG1116	anion transmembrane transporter activity
L2Z49_06380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z49_06385	COG0745	RESPONSE REGULATOR receiver
L2Z49_06395	COG2146	nitrite reductase [NAD(P)H] activity
L2Z49_06395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z49_06400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z49_06405	COG0243	molybdopterin cofactor binding
L2Z49_06415	COG0243	molybdopterin cofactor binding
L2Z49_06420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z49_06435	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z49_06435	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z49_06440	COG0303	'Molybdopterin
L2Z49_06450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z49_06455	COG0697	spore germination
L2Z49_06475	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z49_06480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z49_06535	COG2204	response regulator
L2Z49_06540	COG3852	Histidine kinase
L2Z49_06560	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z49_06565	COG0575	Belongs to the CDS family
L2Z49_06600	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z49_06615	COG2137	regulation of response to DNA damage stimulus
L2Z49_06625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z49_06630	COG1011	Hydrolase
L2Z49_06665	COG1113	amino acid transport
L2Z49_06685	COG0659	secondary active sulfate transmembrane transporter activity
L2Z49_06690	COG2135	peptidase activity
L2Z49_06705	COG3300	MHYT domain
L2Z49_06705	COG5001	Diguanylate cyclase
L2Z49_06725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z49_06725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z49_06725	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z49_06730	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z49_06735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z49_06735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z49_06765	COG0024	Methionine aminopeptidase
L2Z49_06770	COG0583	DNA-binding transcription factor activity
L2Z49_06780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z49_06785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z49_06790	COG0516	GMP reductase activity
L2Z49_06790	COG0517	IMP dehydrogenase activity
L2Z49_06815	COG0552	protein localization to endoplasmic reticulum
L2Z49_06825	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z49_06850	COG4890	Cyd operon protein YbgT
L2Z49_06855	COG1294	oxidase, subunit
L2Z49_06870	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z49_06880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z49_06885	COG4774	siderophore transport
L2Z49_06900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z49_06905	COG0569	domain protein
L2Z49_06910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z49_06940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z49_06945	COG0542	response to heat
L2Z49_06970	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z49_06970	COG1902	pentaerythritol trinitrate reductase activity
L2Z49_07015	COG2323	membrane
L2Z49_07020	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z49_07030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z49_07035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z49_07040	COG0183	Belongs to the thiolase family
L2Z49_07045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z49_07050	COG0596	Alpha beta hydrolase
L2Z49_07055	COG2271	Major facilitator Superfamily
L2Z49_07060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z49_07065	COG3485	protocatechuate 3,4-dioxygenase
L2Z49_07070	COG3485	protocatechuate 3,4-dioxygenase
L2Z49_07075	COG0710	3-dehydroquinate dehydratase activity
L2Z49_07080	COG3420	alginic acid biosynthetic process
L2Z49_07085	COG3659	wide pore channel activity
L2Z49_07090	COG4993	Dehydrogenase
L2Z49_07115	COG1414	Transcriptional regulator
L2Z49_07120	COG0583	DNA-binding transcription factor activity
L2Z49_07125	COG1960	acyl-CoA dehydrogenase activity
L2Z49_07150	COG2814	Major facilitator Superfamily
L2Z49_07160	COG0154	amidase activity
L2Z49_07180	COG4638	Rieske (2fe-2S)
L2Z49_07190	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_07200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z49_07210	COG3733	amine oxidase
L2Z49_07220	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_07230	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z49_07235	COG0183	Belongs to the thiolase family
L2Z49_07240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z49_07245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z49_07255	COG4829	muconolactone delta-isomerase
L2Z49_07260	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z49_07265	COG0583	DNA-binding transcription factor activity
L2Z49_07275	COG2186	Transcriptional regulator
L2Z49_07295	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_07315	COG1960	acyl-CoA dehydrogenase activity
L2Z49_07320	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_07325	COG3829	transcription factor binding
L2Z49_07335	COG3162	membrane
L2Z49_07350	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_07365	COG0753	catalase activity
L2Z49_07385	COG1846	Transcriptional regulator
L2Z49_07390	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z49_07390	COG1902	pentaerythritol trinitrate reductase activity
L2Z49_07400	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2Z49_07430	COG1309	transcriptional regulator
L2Z49_07440	COG1335	isochorismatase
L2Z49_07445	COG0583	DNA-binding transcription factor activity
L2Z49_07455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z49_07455	COG0475	glutathione-regulated potassium exporter activity
L2Z49_07465	COG1473	amidohydrolase
L2Z49_07475	COG2831	hemolysin activation secretion protein
L2Z49_07510	COG2188	Transcriptional regulator
L2Z49_07525	COG0583	DNA-binding transcription factor activity
L2Z49_07555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z49_07585	COG1566	PFAM secretion protein HlyD family protein
L2Z49_07615	COG0129	dihydroxy-acid dehydratase activity
L2Z49_07625	COG0583	DNA-binding transcription factor activity
L2Z49_07630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z49_07640	COG2084	Dehydrogenase
L2Z49_07645	COG2207	Transcriptional regulator
L2Z49_07660	COG1064	alcohol dehydrogenase
L2Z49_07670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z49_07675	COG1120	ATPase activity
L2Z49_07695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z49_07815	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z49_07875	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_07890	COG2207	Transcriptional regulator
L2Z49_07900	COG2205	protein histidine kinase activity
L2Z49_07905	COG0745	RESPONSE REGULATOR receiver
L2Z49_07910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z49_07915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z49_07920	COG1538	Outer membrane efflux protein
L2Z49_07960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z49_08005	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z49_08015	COG0753	catalase activity
L2Z49_08030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z49_08090	COG1535	isochorismatase
L2Z49_08090	COG3433	isochorismatase activity
L2Z49_08095	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_08100	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z49_08105	COG4149	molybdate abc transporter
L2Z49_08110	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z49_08120	COG4638	Rieske (2fe-2S)
L2Z49_08125	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z49_08130	COG0543	2 iron, 2 sulfur cluster binding
L2Z49_08130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z49_08155	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_08170	COG2207	Transcriptional regulator
L2Z49_08175	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_08180	COG2610	gluconate transmembrane transporter activity
L2Z49_08190	COG0583	DNA-binding transcription factor activity
L2Z49_08200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z49_08205	COG2031	fatty acid transporter
L2Z49_08210	COG0183	Belongs to the thiolase family
L2Z49_08215	COG0583	DNA-binding transcription factor activity
L2Z49_08220	COG0583	DNA-binding transcription factor activity
L2Z49_08235	COG1027	Aspartate ammonia-lyase
L2Z49_08245	COG0477	Major facilitator Superfamily
L2Z49_08265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z49_08270	COG4521	taurine ABC transporter
L2Z49_08285	COG2188	Transcriptional regulator
L2Z49_08295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z49_08300	COG1733	regulation of RNA biosynthetic process
L2Z49_08305	COG3708	Transcriptional regulator
L2Z49_08305	COG2207	Transcriptional regulator
L2Z49_08320	COG0730	response to heat
L2Z49_08335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z49_08335	COG3453	Protein conserved in bacteria
L2Z49_08345	COG3781	membrane
L2Z49_08350	COG1063	alcohol dehydrogenase
L2Z49_08360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z49_08365	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z49_08370	COG0022	dehydrogenase e1 component
L2Z49_08375	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z49_08405	COG3706	GGDEF domain
L2Z49_08420	COG0133	tryptophan synthase activity
L2Z49_08430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z49_08465	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z49_08490	COG2226	methyltransferase
L2Z49_08545	COG0842	Transport permease protein
L2Z49_08550	COG0842	Transport permease protein
L2Z49_08555	COG1131	(ABC) transporter
L2Z49_08570	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z49_08575	COG4773	Receptor
L2Z49_08595	COG0730	response to heat
L2Z49_08600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z49_08620	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z49_08635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z49_08675	COG4264	IucA IucC family
L2Z49_08680	COG4264	IucA IucC family
L2Z49_08685	COG2814	Major facilitator Superfamily
L2Z49_08700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z49_08715	COG1960	acyl-CoA dehydrogenase activity
L2Z49_08720	COG1960	acyl-CoA dehydrogenase activity
L2Z49_08725	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z49_08730	COG2207	Transcriptional regulator
L2Z49_08735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z49_08740	COG0776	regulation of translation
L2Z49_08765	COG0822	iron-sulfur transferase activity
L2Z49_08770	COG0316	Belongs to the HesB IscA family
L2Z49_08800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z49_08820	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z49_08825	COG0702	epimerase
L2Z49_08860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z49_08870	COG0339	signal peptide processing
L2Z49_08920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z49_09050	COG3728	DNA packaging
L2Z49_09050	COG5484	DNA packaging
L2Z49_09145	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z49_09175	COG0776	regulation of translation
L2Z49_09240	COG0084	hydrolase, TatD family'
L2Z49_09260	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z49_09265	COG1132	(ABC) transporter
L2Z49_09275	COG0811	peptide transport
L2Z49_09280	COG1475	DNA binding
L2Z49_09285	COG1192	Involved in chromosome partitioning
L2Z49_09295	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z49_09310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z49_09315	COG0191	fructose-bisphosphate aldolase activity
L2Z49_09335	COG0424	maF-like protein
L2Z49_09340	COG2850	peptidyl-arginine hydroxylation
L2Z49_09350	COG0640	Transcriptional regulator
L2Z49_09360	COG3619	membrane
L2Z49_09365	COG3122	Protein conserved in bacteria
L2Z49_09370	COG1132	(ABC) transporter
L2Z49_09390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z49_09395	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z49_09405	COG0506	proline dehydrogenase activity
L2Z49_09405	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z49_09405	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z49_09425	COG3698	Phosphodiester glycosidase
L2Z49_09435	COG2353	YceI-like domain
L2Z49_09445	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z49_09490	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z49_09490	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z49_09515	COG3539	Fimbrial protein
L2Z49_09520	COG3121	Chaperone
L2Z49_09545	COG0697	spore germination
L2Z49_09575	COG0583	DNA-binding transcription factor activity
L2Z49_09610	COG1522	sequence-specific DNA binding
L2Z49_09620	COG1126	abc transporter atp-binding protein
L2Z49_09625	COG0765	amino acid transport
L2Z49_09630	COG0765	amino acid transport
L2Z49_09660	COG1464	Belongs to the NlpA lipoprotein family
L2Z49_09670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z49_09675	COG2011	ABC-type metal ion transport system permease component
L2Z49_09680	COG0012	GTP binding
L2Z49_09705	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z49_09745	COG0386	Belongs to the glutathione peroxidase family
L2Z49_09755	COG0436	Aminotransferase
L2Z49_09795	COG3634	alkyl hydroperoxide reductase activity
L2Z49_09810	COG0583	DNA-binding transcription factor activity
L2Z49_09815	COG0798	PFAM Bile acid sodium symporter
L2Z49_09820	COG0640	Transcriptional regulator
L2Z49_09835	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z49_09845	COG0583	DNA-binding transcription factor activity
L2Z49_09855	COG1953	Uracil, thiamine, allantoin
L2Z49_09865	COG2175	clavaminate synthase activity
L2Z49_09870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z49_09875	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z49_09880	COG4521	taurine ABC transporter
L2Z49_09890	COG0477	Major facilitator Superfamily
L2Z49_09910	COG1271	oxidase subunit
L2Z49_09915	COG1294	oxidase, subunit
L2Z49_09925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z49_09945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z49_09965	COG3052	prosthetic group binding
L2Z49_09970	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z49_09980	COG2814	Major facilitator Superfamily
L2Z49_10000	COG1346	cytolysis
L2Z49_10010	COG0583	DNA-binding transcription factor activity
L2Z49_10015	COG0625	glutathione transferase activity
L2Z49_10020	COG0625	glutathione transferase activity
L2Z49_10025	COG0583	DNA-binding transcription factor activity
L2Z49_10040	COG1045	serine acetyltransferase
L2Z49_10045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z49_10050	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z49_10060	COG1280	lysine exporter protein (LysE YggA)
L2Z49_10075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z49_10080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z49_10085	COG1126	abc transporter atp-binding protein
L2Z49_10090	COG0765	amino acid transport
L2Z49_10095	COG0765	amino acid transport
L2Z49_10115	COG0784	Response regulator, receiver
L2Z49_10115	COG2205	protein histidine kinase activity
L2Z49_10135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z49_10155	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_10205	COG0583	DNA-binding transcription factor activity
L2Z49_10225	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z49_10230	COG1309	transcriptional regulator
L2Z49_10235	COG1960	acyl-CoA dehydrogenase activity
L2Z49_10240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z49_10245	COG1024	Enoyl-CoA hydratase
L2Z49_10250	COG4770	biotin carboxylase activity
L2Z49_10260	COG0583	DNA-binding transcription factor activity
L2Z49_10275	COG1960	acyl-CoA dehydrogenase activity
L2Z49_10285	COG2814	Major facilitator Superfamily
L2Z49_10295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z49_10300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z49_10305	COG2814	Major facilitator Superfamily
L2Z49_10310	COG1960	acyl-CoA dehydrogenase activity
L2Z49_10315	COG1024	Enoyl-CoA hydratase
L2Z49_10320	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_10325	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z49_10330	COG0183	Belongs to the thiolase family
L2Z49_10340	COG2814	Major facilitator Superfamily
L2Z49_10350	COG1024	Enoyl-CoA hydratase
L2Z49_10365	COG1960	acyl-CoA dehydrogenase activity
L2Z49_10370	COG2814	Major facilitator Superfamily
L2Z49_10375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z49_10380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z49_10395	COG3842	ATPase activity
L2Z49_10400	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z49_10410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z49_10415	COG1414	Transcriptional regulator
L2Z49_10425	COG0583	DNA-binding transcription factor activity
L2Z49_10430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z49_10435	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_10445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z49_10455	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_10460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z49_10465	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z49_10470	COG2267	carboxylic ester hydrolase activity
L2Z49_10490	COG3038	cytochrome b561
L2Z49_10495	COG0753	catalase activity
L2Z49_10530	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z49_10540	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z49_10545	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z49_10550	COG0183	Belongs to the thiolase family
L2Z49_10555	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z49_10560	COG1024	Enoyl-CoA hydratase
L2Z49_10565	COG1024	Enoyl-CoA hydratase
L2Z49_10570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z49_10575	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z49_10580	COG3396	Phenylacetate-CoA oxygenase
L2Z49_10585	COG3460	Phenylacetate-CoA oxygenase
L2Z49_10590	COG3396	Phenylacetate-CoA oxygenase
L2Z49_10595	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_10595	COG2030	dehydratase
L2Z49_10600	COG1760	l-serine dehydratase
L2Z49_10605	COG0531	amino acid
L2Z49_10610	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_10635	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z49_10645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z49_10665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z49_10675	COG0789	Transcriptional regulator
L2Z49_10685	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z49_10700	COG2807	transmembrane transport
L2Z49_10705	COG0590	tRNA wobble adenosine to inosine editing
L2Z49_10825	COG1116	anion transmembrane transporter activity
L2Z49_10830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z49_10840	COG0864	Transcriptional regulator
L2Z49_10860	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z49_10865	COG0439	Biotin carboxylase
L2Z49_10880	COG1063	alcohol dehydrogenase
L2Z49_10890	COG1309	transcriptional regulator
L2Z49_10910	COG0038	chloride channel
L2Z49_10915	COG4770	biotin carboxylase activity
L2Z49_10935	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z49_10940	COG0583	DNA-binding transcription factor activity
L2Z49_10990	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z49_11030	COG1560	Kdo2-lipid A biosynthetic process
L2Z49_11040	COG5006	permease, DMT superfamily
L2Z49_11045	COG1522	sequence-specific DNA binding
L2Z49_11060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z49_11070	COG4122	O-methyltransferase activity
L2Z49_11100	COG1538	Outer membrane efflux protein
L2Z49_11110	COG1137	ATPase activity
L2Z49_11115	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z49_11125	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z49_11130	COG0517	IMP dehydrogenase activity
L2Z49_11130	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2Z49_11165	COG2814	Major facilitator Superfamily
L2Z49_11200	COG1278	Cold shock
L2Z49_11235	COG1570	exodeoxyribonuclease VII activity
L2Z49_11285	COG0583	DNA-binding transcription factor activity
L2Z49_11295	COG4638	Rieske (2fe-2S)
L2Z49_11300	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z49_11305	COG0633	Ferredoxin
L2Z49_11305	COG0543	2 iron, 2 sulfur cluster binding
L2Z49_11310	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_11315	COG3135	benzoate transporter
L2Z49_11320	COG2814	Major facilitator Superfamily
L2Z49_11335	COG1643	Atp-dependent helicase
L2Z49_11340	COG0450	alkyl hydroperoxide reductase
L2Z49_11350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z49_11360	COG3634	alkyl hydroperoxide reductase activity
L2Z49_11380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z49_11385	COG0625	glutathione transferase activity
L2Z49_11395	COG2885	chlorophyll binding
L2Z49_11430	COG0542	response to heat
L2Z49_11445	COG1765	OsmC-like protein
L2Z49_11460	COG0667	Aldo Keto reductase
L2Z49_11475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z49_11485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z49_11495	COG0527	aspartate kinase activity
L2Z49_11505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z49_11515	COG3038	cytochrome b561
L2Z49_11520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z49_11525	COG2252	PERMEase
L2Z49_11535	COG2072	flavoprotein involved in K transport
L2Z49_11550	COG1741	Belongs to the pirin family
L2Z49_11555	COG1309	transcriptional regulator
L2Z49_11565	COG0300	oxidoreductase activity
L2Z49_11590	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z49_11590	COG1902	pentaerythritol trinitrate reductase activity
L2Z49_11605	COG4269	membrane
L2Z49_11670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z49_11690	COG4172	Belongs to the ABC transporter superfamily
L2Z49_11695	COG4239	(ABC) transporter, permease
L2Z49_11700	COG4174	ABC transporter (Permease)
L2Z49_11710	COG1388	LysM domain
L2Z49_11710	COG0741	lytic transglycosylase activity
L2Z49_11710	COG1388	LysM domain
L2Z49_11710	COG0741	lytic transglycosylase activity
L2Z49_11715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z49_11755	COG0583	DNA-binding transcription factor activity
L2Z49_11760	COG1279	arginine transmembrane transporter activity
L2Z49_11780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z49_11785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z49_11790	COG0006	proline dipeptidase activity
L2Z49_11875	COG0739	heme binding
L2Z49_12205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z49_12235	COG3384	dioxygenase
L2Z49_12245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z49_12250	COG2878	Part of a membrane complex involved in electron transport
L2Z49_12255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z49_12280	COG0768	penicillin binding
L2Z49_12285	COG0742	ribosomal rna small subunit methyltransferase
L2Z49_12300	COG0830	nickel cation binding
L2Z49_12310	COG0804	urea catabolic process
L2Z49_12350	COG1253	flavin adenine dinucleotide binding
L2Z49_12355	COG2851	Citrate transporter
L2Z49_12405	COG1773	rubredoxin
L2Z49_12410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z49_12420	COG0583	DNA-binding transcription factor activity
L2Z49_12445	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z49_12450	COG4181	ATPase activity
L2Z49_12495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z49_12515	COG0306	phosphate transporter
L2Z49_12525	COG3958	Transketolase
L2Z49_12530	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z49_12535	COG2271	Major facilitator Superfamily
L2Z49_12540	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_12545	COG0583	DNA-binding transcription factor activity
L2Z49_12560	COG2223	nitrite transmembrane transporter activity
L2Z49_12565	COG2207	Transcriptional regulator
L2Z49_12570	COG2066	Belongs to the glutaminase family
L2Z49_12575	COG0242	peptide deformylase activity
L2Z49_12580	COG0477	Major facilitator Superfamily
L2Z49_12590	COG0028	Belongs to the TPP enzyme family
L2Z49_12605	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_12610	COG2267	carboxylic ester hydrolase activity
L2Z49_12620	COG2271	Major facilitator Superfamily
L2Z49_12625	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z49_12635	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_12655	COG1414	Transcriptional regulator
L2Z49_12670	COG1024	Enoyl-CoA hydratase
L2Z49_12680	COG1215	transferase activity, transferring glycosyl groups
L2Z49_12685	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z49_12685	COG0726	polysaccharide deacetylase
L2Z49_12695	COG4681	YaeQ
L2Z49_12705	COG0523	cobalamin synthesis protein
L2Z49_12715	COG1607	acyl-coa hydrolase
L2Z49_12725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z49_12730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z49_12735	COG1309	transcriptional regulator
L2Z49_12760	COG2040	homocysteine
L2Z49_12765	COG0531	amino acid
L2Z49_12820	COG1595	DNA-templated transcription, initiation
L2Z49_12830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z49_12835	COG0477	Major facilitator Superfamily
L2Z49_12880	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
L2Z49_12915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z49_12995	COG0592	DNA-directed DNA polymerase activity
L2Z49_13200	COG1484	DNA-dependent DNA replication
L2Z49_13305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z49_13365	COG0405	Gamma-glutamyltransferase
L2Z49_13370	COG2814	Major facilitator Superfamily
L2Z49_13380	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z49_13395	COG1090	epimerase
L2Z49_13415	COG0420	3'-5' exonuclease activity
L2Z49_13440	COG0735	belongs to the Fur family
L2Z49_13445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z49_13465	COG0121	glutamine amidotransferase
L2Z49_13480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z49_13490	COG0210	DNA helicase
L2Z49_13495	COG2885	chlorophyll binding
L2Z49_13500	COG0204	Acyl-transferase
L2Z49_13515	COG2894	cell division
L2Z49_13535	COG1280	lysine exporter protein (LysE YggA)
L2Z49_13540	COG1674	ftsk spoiiie
L2Z49_13540	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z49_13545	COG0492	ferredoxin-NADP+ reductase activity
L2Z49_13550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z49_13560	COG0456	acetyltransferase
L2Z49_13605	COG1981	membrane
L2Z49_13620	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z49_13620	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z49_13640	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_13650	COG0657	acetylesterase activity
L2Z49_13660	COG0473	3-isopropylmalate dehydrogenase activity
L2Z49_13665	COG0583	DNA-binding transcription factor activity
L2Z49_13685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z49_13710	COG0564	pseudouridine synthase activity
L2Z49_13720	COG0358	DNA primase activity
L2Z49_13735	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z49_13765	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z49_13795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z49_13805	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z49_13805	COG0351	phosphomethylpyrimidine kinase
L2Z49_13805	COG0352	thiamine-phosphate diphosphorylase activity
L2Z49_13810	COG1652	LysM domain
L2Z49_13835	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z49_13840	COG3101	peptidyl-lysine hydroxylation
L2Z49_13845	COG0009	L-threonylcarbamoyladenylate synthase
L2Z49_13850	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z49_13855	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z49_13870	COG4106	trans-aconitate 2-methyltransferase activity
L2Z49_13885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z49_13885	COG2226	methyltransferase
L2Z49_13885	COG0596	Alpha beta hydrolase
L2Z49_13895	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z49_13900	COG2223	nitrite transmembrane transporter activity
L2Z49_13920	COG1196	nuclear chromosome segregation
L2Z49_13930	COG0730	response to heat
L2Z49_13945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z49_13955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z49_14005	COG0489	protein tyrosine kinase activity
L2Z49_14015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z49_14015	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z49_14045	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z49_14050	COG2081	HI0933 family
L2Z49_14060	COG0668	transmembrane transport
L2Z49_14080	COG0583	DNA-binding transcription factor activity
L2Z49_14100	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z49_14105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z49_14135	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z49_14175	COG0745	RESPONSE REGULATOR receiver
L2Z49_14195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z49_14210	COG2205	protein histidine kinase activity
L2Z49_14280	COG4993	Dehydrogenase
L2Z49_14300	COG0384	phenazine biosynthesis protein PhzF
L2Z49_14325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z49_14340	COG0583	DNA-binding transcription factor activity
L2Z49_14370	COG0583	DNA-binding transcription factor activity
L2Z49_14385	COG0583	DNA-binding transcription factor activity
L2Z49_14390	COG1053	succinate dehydrogenase
L2Z49_14400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z49_14405	COG2814	Major facilitator Superfamily
L2Z49_14410	COG1960	acyl-CoA dehydrogenase activity
L2Z49_14415	COG0583	DNA-binding transcription factor activity
L2Z49_14420	COG1063	alcohol dehydrogenase
L2Z49_14450	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z49_14455	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z49_14460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z49_14475	COG3667	copper resistance
L2Z49_14480	COG2132	Multicopper oxidase
L2Z49_14490	COG0561	phosphatase activity
L2Z49_14495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z49_14520	COG1214	PFAM Peptidase M22, glycoprotease
L2Z49_14580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z49_14585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z49_14590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z49_14650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z49_14660	COG1846	Transcriptional regulator
L2Z49_14665	COG1764	response to oxidative stress
L2Z49_14705	COG0037	tRNA processing
L2Z49_14715	COG0248	Ppx GppA phosphatase
L2Z49_14745	COG0072	phenylalanine-tRNA ligase activity
L2Z49_14790	COG1238	metal cluster binding
L2Z49_14795	COG0625	glutathione transferase activity
L2Z49_14810	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z49_14815	COG3028	Belongs to the UPF0307 family
L2Z49_14820	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z49_14840	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z49_14845	COG0617	tRNA 3'-terminal CCA addition
L2Z49_14850	COG1555	photosystem II stabilization
L2Z49_14855	COG3956	TIGRFAM MazG family protein
L2Z49_14865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z49_14885	COG0784	Response regulator, receiver
L2Z49_14885	COG2205	protein histidine kinase activity
L2Z49_14885	COG5002	protein histidine kinase activity
L2Z49_14890	COG1024	Enoyl-CoA hydratase
L2Z49_14895	COG2084	Dehydrogenase
L2Z49_14900	COG3622	Belongs to the hyi family
L2Z49_14930	COG0697	spore germination
L2Z49_14940	COG2814	Major facilitator Superfamily
L2Z49_14945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z49_14955	COG0583	DNA-binding transcription factor activity
L2Z49_14965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z49_14980	COG0084	hydrolase, TatD family'
L2Z49_14995	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z49_15025	COG0440	acetolactate synthase activity
L2Z49_15030	COG0028	Belongs to the TPP enzyme family
L2Z49_15055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z49_15060	COG0577	efflux transmembrane transporter activity
L2Z49_15060	COG1136	(ABC) transporter
L2Z49_15065	COG1538	Outer membrane efflux protein
L2Z49_15080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z49_15085	COG1162	GTPase activity
L2Z49_15095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z49_15115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2Z49_15120	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_15160	COG2986	histidine ammonia-lyase
L2Z49_15175	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z49_15185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z49_15230	COG1426	Protein conserved in bacteria
L2Z49_15265	COG0793	Belongs to the peptidase S41A family
L2Z49_15280	COG2267	carboxylic ester hydrolase activity
L2Z49_15290	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_15295	COG3265	gluconokinase activity
L2Z49_15305	COG0800	Aldolase
L2Z49_15315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z49_15320	COG0857	belongs to the CobB CobQ family
L2Z49_15320	COG0280	phosphate acetyltransferase
L2Z49_15325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z49_15325	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z49_15345	COG0740	serine-type endopeptidase activity
L2Z49_15355	COG4774	siderophore transport
L2Z49_15365	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z49_15375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z49_15375	COG2813	Specifically methylates the guanine in position
L2Z49_15480	COG0788	formyltetrahydrofolate deformylase activity
L2Z49_15505	COG4651	solute:proton antiporter activity
L2Z49_15505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z49_15525	COG0724	RNA recognition motif
L2Z49_15530	COG0210	DNA helicase
L2Z49_15555	COG1733	regulation of RNA biosynthetic process
L2Z49_15565	COG2900	Belongs to the SlyX family
L2Z49_15570	COG0488	(ABC) transporter
L2Z49_15575	COG1280	lysine exporter protein (LysE YggA)
L2Z49_15580	COG1560	Kdo2-lipid A biosynthetic process
L2Z49_15590	COG1301	dicarboxylic acid transport
L2Z49_15645	COG0473	3-isopropylmalate dehydrogenase activity
L2Z49_15710	COG0583	DNA-binding transcription factor activity
L2Z49_15720	COG0625	glutathione transferase activity
L2Z49_15725	COG2378	regulation of single-species biofilm formation
L2Z49_15730	COG0546	phosphoglycolate phosphatase activity
L2Z49_15740	COG1530	ribonuclease E activity
L2Z49_15745	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z49_15760	COG0583	DNA-binding transcription factor activity
L2Z49_15765	COG4221	oxidoreductase activity
L2Z49_15770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z49_15780	COG0534	Mate efflux family protein
L2Z49_15795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z49_15835	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z49_15840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z49_15855	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z49_15865	COG0644	oxidoreductase
L2Z49_15865	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z49_15870	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z49_15875	COG4535	Mg2 and Co2 transporter CorC
L2Z49_15885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z49_15905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z49_15910	COG0475	glutathione-regulated potassium exporter activity
L2Z49_15910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z49_15915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2Z49_15925	COG0484	heat shock protein binding
L2Z49_15930	COG0789	Transcriptional regulator
L2Z49_15935	COG0598	Magnesium transport protein CorA
L2Z49_15950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z49_15955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z49_15960	COG1074	ATP-dependent DNA helicase activity
L2Z49_15965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z49_15995	COG2226	methyltransferase
L2Z49_16010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z49_16015	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z49_16030	COG2111	Na H antiporter
L2Z49_16030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z49_16035	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z49_16040	COG0651	ATP synthesis coupled electron transport
L2Z49_16045	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z49_16050	COG2212	antiporter activity
L2Z49_16055	COG1320	monovalent cation:proton antiporter activity
L2Z49_16070	COG0195	Participates in both transcription termination and antitermination
L2Z49_16120	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2Z49_16125	COG0237	dephospho-CoA kinase activity
L2Z49_16135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z49_16150	COG0497	DNA recombination
L2Z49_16160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z49_16190	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z49_16190	COG2169	Transcriptional regulator
L2Z49_16195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z49_16260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z49_16275	COG0326	Molecular chaperone. Has ATPase activity
L2Z49_16290	COG2056	Na+-H+ antiporter family
L2Z49_16295	COG0596	Alpha beta hydrolase
L2Z49_16390	COG0546	phosphoglycolate phosphatase activity
L2Z49_16395	COG1716	ATPase activity
L2Z49_16440	COG0181	hydroxymethylbilane synthase activity
L2Z49_16450	COG3275	phosphorelay sensor kinase activity
L2Z49_16470	COG1538	Outer membrane efflux protein
L2Z49_16475	COG0697	spore germination
L2Z49_16500	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z49_16505	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z49_16510	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z49_16515	COG0772	Belongs to the SEDS family
L2Z49_16540	COG4974	Belongs to the 'phage' integrase family
L2Z49_16545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z49_16555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z49_16565	COG2197	response regulator
L2Z49_16580	COG0793	Belongs to the peptidase S41A family
L2Z49_16585	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z49_16590	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z49_16630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z49_16630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z49_16640	COG0004	ammonium transporteR
L2Z49_16645	COG0347	Belongs to the P(II) protein family
L2Z49_16730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z49_16775	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z49_16815	COG0659	secondary active sulfate transmembrane transporter activity
L2Z49_16820	COG0589	response to stress
L2Z49_16855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z49_16865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z49_16885	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z49_16900	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z49_16910	COG0477	Major facilitator Superfamily
L2Z49_16915	COG2860	membrane
L2Z49_16925	COG1253	flavin adenine dinucleotide binding
L2Z49_16935	COG2814	Major facilitator Superfamily
L2Z49_16945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z49_16985	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z49_16995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z49_17065	COG0758	DNA mediated transformation
L2Z49_17075	COG0697	spore germination
L2Z49_17080	COG1309	transcriptional regulator
L2Z49_17095	COG0386	Belongs to the glutathione peroxidase family
L2Z49_17160	COG1121	(ABC) transporter
L2Z49_17165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z49_17170	COG1280	lysine exporter protein (LysE YggA)
L2Z49_17175	COG2837	iron assimilation
L2Z49_17185	COG0281	malic enzyme
L2Z49_17230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z49_17230	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z49_17235	COG4399	Belongs to the UPF0754 family
L2Z49_17240	COG2259	Doxx family
L2Z49_17245	COG0586	Pfam SNARE associated Golgi protein
L2Z49_17260	COG1192	Involved in chromosome partitioning
L2Z49_17270	COG0271	Belongs to the BolA IbaG family
L2Z49_17290	COG2267	carboxylic ester hydrolase activity
L2Z49_17310	COG3321	synthase
L2Z49_17310	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z49_17310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z49_17310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z49_17315	COG1960	acyl-CoA dehydrogenase activity
L2Z49_17325	COG2197	response regulator
L2Z49_17335	COG3916	Acyl-homoserine-lactone synthase
L2Z49_17340	COG0477	Major facilitator Superfamily
L2Z49_17345	COG1024	Enoyl-CoA hydratase
L2Z49_17350	COG1024	Enoyl-CoA hydratase
L2Z49_17355	COG1960	acyl-CoA dehydrogenase activity
L2Z49_17360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z49_17380	COG1113	amino acid transport
L2Z49_17385	COG1113	amino acid transport
L2Z49_17390	COG0251	oxidation-reduction process
L2Z49_17430	COG0564	pseudouridine synthase activity
L2Z49_17465	COG1051	belongs to the nudix hydrolase family
L2Z49_17485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z49_17500	COG1802	Transcriptional regulator
L2Z49_17510	COG1448	Aminotransferase
L2Z49_17515	COG0277	FAD linked oxidase domain protein
L2Z49_17525	COG2186	Transcriptional regulator
L2Z49_17535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z49_17545	COG3293	Transposase
L2Z49_17560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z49_17575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z49_17580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z49_17585	COG1216	Glycosyl transferase, family 2
L2Z49_17615	COG2089	acid synthase
L2Z49_17630	COG1083	cytidylyl-transferase
L2Z49_17635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2Z49_17640	COG1086	Polysaccharide biosynthesis protein
L2Z49_17645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z49_17650	COG1596	polysaccharide export
L2Z49_17675	COG0728	peptidoglycan biosynthetic process
L2Z49_17680	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z49_17740	COG0546	phosphoglycolate phosphatase activity
L2Z49_17745	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z49_17765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z49_17770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z49_17775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z49_17780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z49_17785	COG1116	anion transmembrane transporter activity
L2Z49_17790	COG1309	transcriptional regulator
L2Z49_17795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z49_17805	COG0196	riboflavin kinase activity
L2Z49_17810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z49_17820	COG1047	Peptidyl-prolyl cis-trans
L2Z49_17860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z49_17865	COG0657	acetylesterase activity
L2Z49_17890	COG0583	DNA-binding transcription factor activity
L2Z49_17915	COG1002	Type II restriction enzyme, methylase subunits
L2Z49_17920	COG1061	Type III restriction enzyme res subunit
L2Z49_17955	COG2951	lytic endotransglycosylase activity
L2Z49_17960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z49_17975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z49_17985	COG0671	phosphoesterase, PA-phosphatase related
L2Z49_17990	COG0861	Integral membrane protein TerC family
L2Z49_18005	COG0754	glutathionylspermidine amidase activity
L2Z49_18015	COG0402	S-adenosylhomocysteine deaminase activity
L2Z49_18030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z49_18035	COG1230	cation diffusion facilitator family transporter
L2Z49_18050	COG0706	membrane insertase activity
L2Z49_18075	COG0592	DNA-directed DNA polymerase activity
L2Z49_18085	COG0187	DNA topoisomerase II activity
L2Z49_18095	COG0586	Pfam SNARE associated Golgi protein
L2Z49_18100	COG0488	(ABC) transporter
L2Z49_18125	COG0596	Alpha beta hydrolase
L2Z49_18130	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z49_18135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z49_18175	COG0733	neurotransmitter:sodium symporter activity
L2Z49_18215	COG2233	PERMEase
L2Z49_18230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z49_18265	COG2814	Major facilitator Superfamily
L2Z49_18270	COG0656	L-ascorbic acid biosynthetic process
L2Z49_18275	COG0583	DNA-binding transcription factor activity
L2Z49_18290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z49_18295	COG1064	alcohol dehydrogenase
L2Z49_18300	COG2818	Glycosylase
L2Z49_18315	COG1194	a g-specific adenine glycosylase
L2Z49_18335	COG2983	Belongs to the UPF0260 family
L2Z49_18340	COG2133	pyrroloquinoline quinone binding
L2Z49_18345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z49_18350	COG2116	formate transmembrane transporter activity
L2Z49_18370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z49_18375	COG1335	isochorismatase
L2Z49_18380	COG0385	Bile acid
L2Z49_18385	COG0534	Mate efflux family protein
L2Z49_18390	COG1683	Conserved Protein
L2Z49_18410	COG0625	glutathione transferase activity
L2Z49_18420	COG1113	amino acid transport
L2Z49_18430	COG0523	cobalamin synthesis protein
L2Z49_18440	COG2188	Transcriptional regulator
L2Z49_18470	COG0010	Belongs to the arginase family
L2Z49_18480	COG0546	phosphoglycolate phosphatase activity
L2Z49_18485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z49_18490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z49_18500	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z49_18505	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z49_18550	COG0753	catalase activity
L2Z49_18610	COG0534	Mate efflux family protein
L2Z49_18615	COG0436	Aminotransferase
L2Z49_18620	COG2733	membrane
L2Z49_18635	COG2918	glutathione biosynthetic process
L2Z49_18675	COG3150	esterase
L2Z49_18685	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z49_18695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z49_18705	COG2233	PERMEase
L2Z49_18760	COG1393	Belongs to the ArsC family
L2Z49_18765	COG0708	Exodeoxyribonuclease III
L2Z49_18785	COG0189	ligase activity
L2Z49_18805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z49_18815	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z49_18830	COG4942	peptidase
L2Z49_18840	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z49_18850	COG2119	membrane
L2Z49_18855	COG4774	siderophore transport
L2Z49_18860	COG0426	domain, Protein
L2Z49_18860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z49_18885	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z49_18905	COG1902	pentaerythritol trinitrate reductase activity
L2Z49_18910	COG1519	Transferase
L2Z49_18915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z49_18920	COG0668	transmembrane transport
L2Z49_18930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z49_18935	COG1335	isochorismatase
L2Z49_18940	COG1522	sequence-specific DNA binding
L2Z49_18965	COG2205	protein histidine kinase activity
L2Z49_18965	COG0784	Response regulator, receiver
L2Z49_18965	COG2198	Histidine kinase
L2Z49_18970	COG3162	membrane
L2Z49_18975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z49_18985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z49_19000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2Z49_19005	COG1309	transcriptional regulator
L2Z49_19025	COG0352	thiamine-phosphate diphosphorylase activity
L2Z49_19025	COG0351	phosphomethylpyrimidine kinase
L2Z49_19025	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z49_19035	COG2814	Major facilitator Superfamily
L2Z49_19050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z49_19060	COG1113	amino acid transport
L2Z49_19070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z49_19075	COG1012	belongs to the aldehyde dehydrogenase family
L2Z49_19085	COG1335	isochorismatase
L2Z49_19115	COG2814	Major facilitator Superfamily
L2Z49_19120	COG0583	DNA-binding transcription factor activity
L2Z49_19145	COG0667	Aldo Keto reductase
L2Z49_19180	COG1733	regulation of RNA biosynthetic process
L2Z49_19185	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z49_19200	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
L2Z49_19205	COG2207	Transcriptional regulator
L2Z49_19260	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z49_19300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z49_19330	COG0427	acetyl-CoA hydrolase
L2Z49_19355	COG0659	secondary active sulfate transmembrane transporter activity
L2Z49_19360	COG4221	oxidoreductase activity
L2Z49_19365	COG2873	o-acetylhomoserine
L2Z49_19370	COG0488	(ABC) transporter