locus-tag	class	description
NV385_00010	COG0592	DNA-directed DNA polymerase activity
NV385_00020	COG0187	DNA topoisomerase II activity
NV385_00030	COG0586	Pfam SNARE associated Golgi protein
NV385_00035	COG0488	(ABC) transporter
NV385_00060	COG0596	Alpha beta hydrolase
NV385_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NV385_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NV385_00115	COG0733	neurotransmitter:sodium symporter activity
NV385_00155	COG2233	PERMEase
NV385_00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NV385_00205	COG2814	Major facilitator Superfamily
NV385_00210	COG0656	L-ascorbic acid biosynthetic process
NV385_00215	COG0583	DNA-binding transcription factor activity
NV385_00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NV385_00235	COG1064	alcohol dehydrogenase
NV385_00240	COG2818	Glycosylase
NV385_00255	COG1194	a g-specific adenine glycosylase
NV385_00275	COG2983	Belongs to the UPF0260 family
NV385_00280	COG2133	pyrroloquinoline quinone binding
NV385_00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NV385_00290	COG2116	formate transmembrane transporter activity
NV385_00310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NV385_00315	COG1335	isochorismatase
NV385_00320	COG0385	Bile acid
NV385_00325	COG0534	Mate efflux family protein
NV385_00330	COG1683	Conserved Protein
NV385_00350	COG0625	glutathione transferase activity
NV385_00360	COG1113	amino acid transport
NV385_00370	COG0523	cobalamin synthesis protein
NV385_00380	COG2188	Transcriptional regulator
NV385_00410	COG0010	Belongs to the arginase family
NV385_00425	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NV385_00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NV385_00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NV385_00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NV385_00545	COG0534	Mate efflux family protein
NV385_00550	COG0436	Aminotransferase
NV385_00555	COG2733	membrane
NV385_00570	COG2918	glutathione biosynthetic process
NV385_00585	COG0791	NLP P60 protein
NV385_00585	COG1388	LysM domain
NV385_00600	COG3150	esterase
NV385_00610	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_00615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
NV385_00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NV385_00635	COG2233	PERMEase
NV385_00640	COG2351	hydroxyisourate hydrolase activity
NV385_00675	COG3706	GGDEF domain
NV385_00690	COG1393	Belongs to the ArsC family
NV385_00695	COG0708	Exodeoxyribonuclease III
NV385_00715	COG0189	ligase activity
NV385_00735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NV385_00745	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NV385_00760	COG4942	peptidase
NV385_00770	COG0508	dehydrogenase complex catalyzes the overall conversion of
NV385_00780	COG2119	membrane
NV385_00785	COG4774	siderophore transport
NV385_00790	COG0426	domain, Protein
NV385_00790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NV385_00815	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NV385_00835	COG1902	pentaerythritol trinitrate reductase activity
NV385_00840	COG1519	Transferase
NV385_00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NV385_00850	COG0668	transmembrane transport
NV385_00860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NV385_00865	COG1335	isochorismatase
NV385_00870	COG1522	sequence-specific DNA binding
NV385_00875	COG3328	transposase activity
NV385_00905	COG2205	protein histidine kinase activity
NV385_00905	COG2198	Histidine kinase
NV385_00905	COG0784	Response regulator, receiver
NV385_00910	COG3162	membrane
NV385_00915	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NV385_00925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NV385_00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NV385_00950	COG1309	transcriptional regulator
NV385_00970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NV385_00970	COG0352	thiamine-phosphate diphosphorylase activity
NV385_00970	COG0351	phosphomethylpyrimidine kinase
NV385_00980	COG2814	Major facilitator Superfamily
NV385_00995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NV385_01005	COG1113	amino acid transport
NV385_01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NV385_01020	COG1012	belongs to the aldehyde dehydrogenase family
NV385_01030	COG1335	isochorismatase
NV385_01060	COG2814	Major facilitator Superfamily
NV385_01065	COG0583	DNA-binding transcription factor activity
NV385_01085	COG0667	Aldo Keto reductase
NV385_01120	COG1733	regulation of RNA biosynthetic process
NV385_01125	COG2249	NAD(P)H dehydrogenase (quinone) activity
NV385_01190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NV385_01205	COG2329	Antibiotic biosynthesis monooxygenase
NV385_01235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NV385_01265	COG0427	acetyl-CoA hydrolase
NV385_01290	COG0659	secondary active sulfate transmembrane transporter activity
NV385_01295	COG4221	oxidoreductase activity
NV385_01300	COG2873	o-acetylhomoserine
NV385_01305	COG0488	(ABC) transporter
NV385_01390	COG0833	amino acid
NV385_01435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NV385_01440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NV385_01455	COG2226	methyltransferase
NV385_01505	COG0069	glutamate synthase activity
NV385_01505	COG0070	glutamate synthase
NV385_01505	COG0067	glutamate synthase
NV385_01510	COG0493	'glutamate synthase
NV385_01520	COG1704	LemA family
NV385_01525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NV385_01545	COG3307	-O-antigen
NV385_01570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NV385_01585	COG0194	GDP metabolic process
NV385_01635	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NV385_01655	COG5380	lipid catabolic process
NV385_01660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NV385_01685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NV385_01690	COG0277	FAD linked oxidase domain protein
NV385_01700	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NV385_01705	COG2249	NAD(P)H dehydrogenase (quinone) activity
NV385_01720	COG1289	transmembrane transporter activity
NV385_01730	COG0628	permease
NV385_01735	COG1192	Involved in chromosome partitioning
NV385_01765	COG0833	amino acid
NV385_01770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NV385_01775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NV385_01785	COG1012	belongs to the aldehyde dehydrogenase family
NV385_01825	COG0583	DNA-binding transcription factor activity
NV385_01870	COG0517	IMP dehydrogenase activity
NV385_01875	COG1983	PspC domain protein
NV385_01885	COG1960	acyl-CoA dehydrogenase activity
NV385_01900	COG0408	coproporphyrinogen oxidase activity
NV385_01920	COG0513	Belongs to the DEAD box helicase family
NV385_01930	COG1127	ABC transporter
NV385_01935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NV385_01945	COG2854	intermembrane phospholipid transfer
NV385_01955	COG0598	Magnesium transport protein CorA
NV385_01965	COG0494	nUDIX hydrolase
NV385_01970	COG1040	competence protein
NV385_01975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NV385_01995	COG1946	Acyl-CoA thioesterase
NV385_02000	COG1301	dicarboxylic acid transport
NV385_02015	COG1959	2 iron, 2 sulfur cluster binding
NV385_02020	COG1017	nitric oxide dioxygenase activity
NV385_02020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NV385_02025	COG0433	COG0433 Predicted ATPase
NV385_02030	COG0626	cystathionine gamma-synthase activity
NV385_02185	COG1960	acyl-CoA dehydrogenase activity
NV385_02190	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
NV385_02220	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
NV385_02225	COG0339	signal peptide processing
NV385_02230	COG0557	exoribonuclease II activity
NV385_02275	COG0179	Fumarylacetoacetate (FAA) hydrolase
NV385_02280	COG2169	Transcriptional regulator
NV385_02285	COG0697	spore germination
NV385_02290	COG1295	ribonuclease BN
NV385_02325	COG1702	phosphate starvation-inducible protein PhoH
NV385_02335	COG0741	lytic transglycosylase activity
NV385_02335	COG0739	heme binding
NV385_02335	COG1196	nuclear chromosome segregation
NV385_02365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NV385_02370	COG1183	phosphatidylcholine synthase activity
NV385_02415	COG1960	acyl-CoA dehydrogenase activity
NV385_02420	COG1309	transcriptional regulator
NV385_02435	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NV385_02440	COG1960	acyl-CoA dehydrogenase activity
NV385_02460	COG2969	positive regulation of protein catabolic process
NV385_02470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NV385_02485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NV385_02490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NV385_02510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NV385_02520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NV385_02525	COG1408	metallophosphoesterase
NV385_02535	COG2199	diguanylate cyclase activity
NV385_02595	COG1607	acyl-coa hydrolase
NV385_02625	COG2350	Protein conserved in bacteria
NV385_02635	COG0613	PHP domain protein
NV385_02640	COG3781	membrane
NV385_02650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NV385_02655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NV385_02665	COG1862	Preprotein translocase
NV385_02695	COG2205	protein histidine kinase activity
NV385_02700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NV385_02720	COG0726	polysaccharide deacetylase
NV385_02725	COG0463	Glycosyl transferase, family 2
NV385_02730	COG0438	transferase activity, transferring glycosyl groups
NV385_02795	COG0625	glutathione transferase activity
NV385_02800	COG0583	DNA-binding transcription factor activity
NV385_02805	COG1960	acyl-CoA dehydrogenase activity
NV385_02810	COG1960	acyl-CoA dehydrogenase activity
NV385_02820	COG2205	protein histidine kinase activity
NV385_02825	COG0745	RESPONSE REGULATOR receiver
NV385_02830	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NV385_02850	COG2096	Adenosyltransferase
NV385_02900	COG0285	dihydrofolate synthase activity
NV385_02920	COG0450	alkyl hydroperoxide reductase
NV385_02935	COG0477	Major facilitator Superfamily
NV385_02940	COG1272	protein, Hemolysin III
NV385_02970	COG0183	Belongs to the thiolase family
NV385_02975	COG2207	Transcriptional regulator
NV385_02995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NV385_03015	COG0183	Belongs to the thiolase family
NV385_03025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
NV385_03025	COG2885	chlorophyll binding
NV385_03035	COG1690	Belongs to the RtcB family
NV385_03040	COG0833	amino acid
NV385_03050	COG2233	PERMEase
NV385_03055	COG1217	gtp-binding protein TYPA
NV385_03080	COG2094	Belongs to the DNA glycosylase MPG family
NV385_03100	COG1902	pentaerythritol trinitrate reductase activity
NV385_03115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NV385_03120	COG0354	folic acid binding
NV385_03130	COG3189	MarR family transcriptional regulator
NV385_03135	COG2824	Alkylphosphonate utilization operon protein PhnA
NV385_03140	COG3422	double-strand break repair
NV385_03185	COG0840	transmembrane signaling receptor activity
NV385_03205	COG5510	response to toxic substance
NV385_03215	COG2832	Protein of unknown function (DUF454)
NV385_03220	COG1376	ErfK ybiS ycfS ynhG family protein
NV385_03260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NV385_03270	COG1289	transmembrane transporter activity
NV385_03275	COG2814	Major facilitator Superfamily
NV385_03295	COG1115	amino acid carrier protein
NV385_03300	COG1752	Esterase of the alpha-beta hydrolase superfamily
NV385_03305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NV385_03310	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
NV385_03340	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NV385_03350	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NV385_03355	COG1077	Cell shape determining protein MreB Mrl
NV385_03360	COG1792	Involved in formation and maintenance of cell shape
NV385_03365	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NV385_03370	COG0424	maF-like protein
NV385_03375	COG1530	ribonuclease E activity
NV385_03385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NV385_03395	COG0560	Phosphoserine phosphatase
NV385_03405	COG2249	NAD(P)H dehydrogenase (quinone) activity
NV385_03430	COG2207	Transcriptional regulator
NV385_03450	COG1113	amino acid transport
NV385_03455	COG2828	Protein conserved in bacteria
NV385_03460	COG0142	geranyltranstransferase activity
NV385_03465	COG2315	Protein conserved in bacteria
NV385_03480	COG1752	Esterase of the alpha-beta hydrolase superfamily
NV385_03500	COG2194	sulfuric ester hydrolase activity
NV385_03505	COG0745	RESPONSE REGULATOR receiver
NV385_03510	COG0642	Histidine kinase
NV385_03520	COG0004	ammonium transporteR
NV385_03525	COG0583	DNA-binding transcription factor activity
NV385_03545	COG0525	valine-tRNA ligase activity
NV385_03555	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_03565	COG0393	Putative heavy-metal-binding
NV385_03570	COG0393	Putative heavy-metal-binding
NV385_03575	COG1538	Outer membrane efflux protein
NV385_03585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NV385_03590	COG0671	phosphoesterase, PA-phosphatase related
NV385_03620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NV385_03635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NV385_03635	COG1648	precorrin-2 dehydrogenase activity
NV385_03640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NV385_03645	COG1733	regulation of RNA biosynthetic process
NV385_03655	COG0531	amino acid
NV385_03670	COG0321	lipoyl(octanoyl) transferase activity
NV385_03675	COG2921	Belongs to the UPF0250 family
NV385_03715	COG2009	succinate dehydrogenase
NV385_03720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NV385_03725	COG1053	succinate dehydrogenase
NV385_03730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NV385_03755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NV385_03775	COG2354	Protein conserved in bacteria
NV385_03780	COG2321	neutral zinc metallopeptidase
NV385_03800	COG2843	Capsule synthesis protein
NV385_03815	COG0589	response to stress
NV385_03835	COG0505	Belongs to the CarA family
NV385_03860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NV385_03865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NV385_03915	COG0477	Major facilitator Superfamily
NV385_03920	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NV385_03935	COG1597	lipid kinase activity
NV385_03940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NV385_03970	COG0584	glycerophosphoryl diester phosphodiesterase
NV385_03990	COG0741	lytic transglycosylase activity
NV385_04010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NV385_04025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NV385_04055	COG0778	Nitroreductase
NV385_04070	COG1929	Belongs to the glycerate kinase type-1 family
NV385_04075	COG0243	molybdopterin cofactor binding
NV385_04080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NV385_04085	COG3339	Conserved Protein
NV385_04095	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NV385_04110	COG1113	amino acid transport
NV385_04120	COG0019	diaminopimelate decarboxylase activity
NV385_04130	COG1280	lysine exporter protein (LysE YggA)
NV385_04135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NV385_04165	COG0463	Glycosyl transferase, family 2
NV385_04185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NV385_04220	COG4591	ABC-type transport system involved in lipoprotein release permease component
NV385_04225	COG1136	(ABC) transporter
NV385_04230	COG0658	competence protein
NV385_04230	COG2333	competence protein COMEC
NV385_04240	COG0616	signal peptide processing
NV385_04240	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
NV385_04245	COG0596	Alpha beta hydrolase
NV385_04250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NV385_04260	COG0628	permease
NV385_04295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NV385_04315	COG0823	Involved in the tonB-independent uptake of proteins
NV385_04335	COG0824	Thioesterase
NV385_04340	COG1473	amidohydrolase
NV385_04360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NV385_04360	COG0047	phosphoribosylformylglycinamidine synthase activity
NV385_04365	COG2814	Major facilitator Superfamily
NV385_04380	COG1024	Enoyl-CoA hydratase
NV385_04385	COG1051	belongs to the nudix hydrolase family
NV385_04385	COG1056	cytidyltransferase-related domain
NV385_04395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NV385_04410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NV385_04425	COG4625	pathogenesis
NV385_04430	COG0583	DNA-binding transcription factor activity
NV385_04435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NV385_04440	COG4208	sulfate ABC transporter
NV385_04445	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NV385_04455	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NV385_04460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NV385_04465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NV385_04485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NV385_04500	COG0681	Belongs to the peptidase S26 family
NV385_04515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NV385_04525	COG1381	Involved in DNA repair and RecF pathway recombination
NV385_04530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NV385_04540	COG4221	oxidoreductase activity
NV385_04570	COG0436	Aminotransferase
NV385_04590	COG0556	nucleotide-excision repair
NV385_04645	COG2070	2-Nitropropane dioxygenase
NV385_04675	COG1215	transferase activity, transferring glycosyl groups
NV385_04690	COG0415	Belongs to the DNA photolyase family
NV385_04700	COG1252	NADH dehydrogenase
NV385_04705	COG1686	Belongs to the peptidase S11 family
NV385_04720	COG1187	pseudouridine synthase activity
NV385_04745	COG0477	Major facilitator Superfamily
NV385_04750	COG0583	DNA-binding transcription factor activity
NV385_04755	COG1823	symporter activity
NV385_04765	COG0612	Peptidase, M16
NV385_04790	COG0352	thiamine-phosphate diphosphorylase activity
NV385_04825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NV385_04840	COG1309	transcriptional regulator
NV385_04850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NV385_04855	COG0076	glutamate decarboxylase activity
NV385_04865	COG1522	sequence-specific DNA binding
NV385_04870	COG3961	Belongs to the TPP enzyme family
NV385_04875	COG1113	amino acid transport
NV385_04880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NV385_04885	COG0573	inorganic phosphate transmembrane transporter activity
NV385_04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NV385_04900	COG0616	signal peptide processing
NV385_04935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NV385_04940	COG1686	Belongs to the peptidase S11 family
NV385_04965	COG0583	DNA-binding transcription factor activity
NV385_04970	COG1067	ATP-dependent peptidase activity
NV385_05015	COG1966	Carbon starvation protein
NV385_05020	COG2879	small protein
NV385_05055	COG2508	Transcriptional regulator
NV385_05055	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NV385_05075	COG1113	amino acid transport
NV385_05080	COG0583	DNA-binding transcription factor activity
NV385_05085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NV385_05090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NV385_05100	COG1012	belongs to the aldehyde dehydrogenase family
NV385_05110	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NV385_05115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NV385_05115	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NV385_05150	COG2814	Major facilitator Superfamily
NV385_05155	COG4948	Mandelate Racemase Muconate Lactonizing
NV385_05165	COG1309	transcriptional regulator
NV385_05185	COG1741	Belongs to the pirin family
NV385_05195	COG2964	Protein conserved in bacteria
NV385_05210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NV385_05220	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NV385_05225	COG4605	iron ion homeostasis
NV385_05230	COG4604	ABC transporter, ATP-binding protein
NV385_05235	COG4607	ABC-type enterochelin transport system periplasmic component
NV385_05240	COG4774	siderophore transport
NV385_05250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NV385_05255	COG1021	2,3-dihydroxybenzoate-AMP ligase
NV385_05260	COG1535	isochorismatase
NV385_05260	COG3433	isochorismatase activity
NV385_05275	COG1132	(ABC) transporter
NV385_05280	COG1132	(ABC) transporter
NV385_05285	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NV385_05295	COG1169	isochorismate synthase
NV385_05310	COG3739	integral membrane protein
NV385_05335	COG0302	gtp cyclohydrolase
NV385_05345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NV385_05375	COG0308	aminopeptidase N
NV385_05380	COG0512	Glutamine amidotransferase of anthranilate synthase
NV385_05395	COG0174	glutamine synthetase
NV385_05405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NV385_05440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NV385_05445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NV385_05450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NV385_05470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NV385_05475	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NV385_05480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NV385_05495	COG1960	acyl-CoA dehydrogenase activity
NV385_05500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NV385_05505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NV385_05515	COG2223	nitrite transmembrane transporter activity
NV385_05525	COG0024	Methionine aminopeptidase
NV385_05530	COG0052	Belongs to the universal ribosomal protein uS2 family
NV385_05545	COG2207	Transcriptional regulator
NV385_05570	COG2951	lytic endotransglycosylase activity
NV385_05575	COG0772	Belongs to the SEDS family
NV385_05590	COG0842	Transport permease protein
NV385_05595	COG1131	(ABC) transporter
NV385_05640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NV385_05655	COG4215	(ABC) transporter
NV385_05660	COG4160	amino acid transport
NV385_05665	COG4598	ABC transporter
NV385_05675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NV385_05680	COG0826	peptidase U32
NV385_05685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NV385_05705	COG1720	tRNA m6t6A37 methyltransferase activity
NV385_05715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NV385_05730	COG0642	Histidine kinase
NV385_05740	COG0494	nUDIX hydrolase
NV385_05750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NV385_05755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NV385_05760	COG3139	Protein of unknown function (DUF1315)
NV385_05765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NV385_05770	COG1301	dicarboxylic acid transport
NV385_05775	COG1960	acyl-CoA dehydrogenase activity
NV385_05780	COG2819	hydrolase of the alpha beta superfamily
NV385_05790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NV385_05800	COG2195	Cleaves the N-terminal amino acid of tripeptides
NV385_05805	COG1234	tRNA 3'-trailer cleavage
NV385_05835	COG2363	Small membrane protein
NV385_05860	COG0513	Belongs to the DEAD box helicase family
NV385_05870	COG0778	Nitroreductase
NV385_06075	COG5410	chromosome segregation
NV385_06215	COG0739	heme binding
NV385_06215	COG1196	nuclear chromosome segregation
NV385_06215	COG0741	lytic transglycosylase activity
NV385_06460	COG5410	chromosome segregation
NV385_06600	COG0739	heme binding
NV385_06600	COG1196	nuclear chromosome segregation
NV385_06600	COG0741	lytic transglycosylase activity
NV385_06670	COG1286	toxin biosynthetic process
NV385_06695	COG4783	chaperone-mediated protein folding
NV385_06700	COG1610	YqeY-like protein
NV385_06800	COG3111	PFAM Bacterial OB fold (BOF) protein
NV385_06825	COG3243	poly(R)-hydroxyalkanoic acid synthase
NV385_06830	COG0786	glutamate:sodium symporter activity
NV385_06840	COG2186	Transcriptional regulator
NV385_06890	COG0477	Major facilitator Superfamily
NV385_06920	COG2985	domain, Protein
NV385_06930	COG2995	paraquat-inducible protein a
NV385_06935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NV385_06935	COG3008	intermembrane lipid transfer
NV385_06945	COG1794	racemase activity, acting on amino acids and derivatives
NV385_07040	COG0488	(ABC) transporter
NV385_07045	COG3173	Aminoglycoside phosphotransferase
NV385_07055	COG2433	Pfam Transposase IS66
NV385_07065	COG1741	Belongs to the pirin family
NV385_07080	COG2072	flavoprotein involved in K transport
NV385_07090	COG2252	PERMEase
NV385_07095	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NV385_07100	COG3038	cytochrome b561
NV385_07110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NV385_07120	COG0527	aspartate kinase activity
NV385_07130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NV385_07140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NV385_07155	COG0667	Aldo Keto reductase
NV385_07175	COG1765	OsmC-like protein
NV385_07190	COG0542	response to heat
NV385_07225	COG2885	chlorophyll binding
NV385_07235	COG0625	glutathione transferase activity
NV385_07240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NV385_07260	COG3634	alkyl hydroperoxide reductase activity
NV385_07270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NV385_07280	COG0450	alkyl hydroperoxide reductase
NV385_07285	COG1643	Atp-dependent helicase
NV385_07300	COG2814	Major facilitator Superfamily
NV385_07305	COG3135	benzoate transporter
NV385_07310	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_07315	COG0543	2 iron, 2 sulfur cluster binding
NV385_07315	COG0633	Ferredoxin
NV385_07320	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NV385_07325	COG4638	Rieske (2fe-2S)
NV385_07335	COG0583	DNA-binding transcription factor activity
NV385_07385	COG1570	exodeoxyribonuclease VII activity
NV385_07415	COG1280	lysine exporter protein (LysE YggA)
NV385_07420	COG1278	Cold shock
NV385_07460	COG2814	Major facilitator Superfamily
NV385_07495	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NV385_07495	COG0517	IMP dehydrogenase activity
NV385_07500	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NV385_07510	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
NV385_07515	COG1137	ATPase activity
NV385_07520	COG1538	Outer membrane efflux protein
NV385_07550	COG4122	O-methyltransferase activity
NV385_07560	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NV385_07575	COG1522	sequence-specific DNA binding
NV385_07580	COG5006	permease, DMT superfamily
NV385_07590	COG1560	Kdo2-lipid A biosynthetic process
NV385_07605	COG2814	Major facilitator Superfamily
NV385_07625	COG1250	3-hydroxyacyl-CoA dehydrogenase
NV385_07675	COG0583	DNA-binding transcription factor activity
NV385_07680	COG1914	H( )-stimulated, divalent metal cation uptake system
NV385_07700	COG4770	biotin carboxylase activity
NV385_07705	COG0038	chloride channel
NV385_07725	COG1309	transcriptional regulator
NV385_07735	COG1063	alcohol dehydrogenase
NV385_07750	COG0439	Biotin carboxylase
NV385_07755	COG2249	NAD(P)H dehydrogenase (quinone) activity
NV385_07775	COG0864	Transcriptional regulator
NV385_07805	COG1301	dicarboxylic acid transport
NV385_07815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NV385_07820	COG2011	ABC-type metal ion transport system permease component
NV385_07825	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NV385_07830	COG1464	Belongs to the NlpA lipoprotein family
NV385_07835	COG0151	Belongs to the GarS family
NV385_07840	COG0138	bifunctional purine biosynthesis protein purh
NV385_07845	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NV385_07875	COG2308	Evidence 4 Homologs of previously reported genes of
NV385_07885	COG1305	Transglutaminase-like
NV385_07895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NV385_07900	COG0305	Participates in initiation and elongation during chromosome replication
NV385_07925	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NV385_07935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NV385_07940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NV385_07965	COG1649	PFAM Uncharacterised BCR, COG1649
NV385_07965	COG0726	polysaccharide deacetylase
NV385_07970	COG1215	transferase activity, transferring glycosyl groups
NV385_07975	COG3658	cytochrome
NV385_07985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NV385_08000	COG0583	DNA-binding transcription factor activity
NV385_08020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NV385_08025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NV385_08040	COG1960	acyl-CoA dehydrogenase activity
NV385_08045	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NV385_08050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NV385_08075	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NV385_08080	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NV385_08090	COG2205	protein histidine kinase activity
NV385_08095	COG0745	RESPONSE REGULATOR receiver
NV385_08100	COG0174	glutamine synthetase
NV385_08120	COG0729	surface antigen
NV385_08145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NV385_08150	COG2814	Major facilitator Superfamily
NV385_08165	COG0583	DNA-binding transcription factor activity
NV385_08180	COG1187	pseudouridine synthase activity
NV385_08200	COG0802	atpase or kinase
NV385_08205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NV385_08215	COG1923	regulation of RNA biosynthetic process
NV385_08220	COG0697	spore germination
NV385_08235	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NV385_08245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NV385_08250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NV385_08250	COG0519	Catalyzes the synthesis of GMP from XMP
NV385_08255	COG4302	ethanolamine ammonia-lyase activity
NV385_08260	COG4303	Ethanolamine ammonia lyase large subunit
NV385_08265	COG0531	amino acid
NV385_08285	COG1454	alcohol dehydrogenase
NV385_08290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NV385_08300	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NV385_08320	COG0308	aminopeptidase N
NV385_08330	COG4221	oxidoreductase activity
NV385_08340	COG1605	Chorismate mutase
NV385_08360	COG1309	transcriptional regulator
NV385_08370	COG0668	transmembrane transport
NV385_08405	COG4773	Receptor
NV385_08425	COG0488	(ABC) transporter
NV385_08430	COG0589	response to stress
NV385_08455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NV385_08465	COG3135	benzoate transporter
NV385_08470	COG1522	sequence-specific DNA binding
NV385_08480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NV385_08485	COG0583	DNA-binding transcription factor activity
NV385_08495	COG0183	Belongs to the thiolase family
NV385_08505	COG2030	dehydratase
NV385_08510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NV385_08525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NV385_08535	COG0824	Thioesterase
NV385_08540	COG1454	alcohol dehydrogenase
NV385_08550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NV385_08570	COG0069	glutamate synthase activity
NV385_08920	COG2814	Major facilitator Superfamily
NV385_08935	COG0511	ligase activity, forming carbon-carbon bonds
NV385_08955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NV385_08955	COG1116	anion transmembrane transporter activity
NV385_08960	COG0745	RESPONSE REGULATOR receiver
NV385_08970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NV385_08970	COG2146	nitrite reductase [NAD(P)H] activity
NV385_08975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NV385_08980	COG0243	molybdopterin cofactor binding
NV385_08990	COG0243	molybdopterin cofactor binding
NV385_08995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NV385_09010	COG0521	Mo-molybdopterin cofactor biosynthetic process
NV385_09010	COG0315	cyclic pyranopterin monophosphate synthase activity
NV385_09015	COG0303	'Molybdopterin
NV385_09025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NV385_09030	COG0697	spore germination
NV385_09050	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
NV385_09055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NV385_09120	COG2204	response regulator
NV385_09125	COG3852	Histidine kinase
NV385_09145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NV385_09150	COG0575	Belongs to the CDS family
NV385_09185	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NV385_09200	COG2137	regulation of response to DNA damage stimulus
NV385_09210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NV385_09215	COG1011	Hydrolase
NV385_09240	COG1522	sequence-specific DNA binding
NV385_09250	COG1113	amino acid transport
NV385_09270	COG0659	secondary active sulfate transmembrane transporter activity
NV385_09275	COG2135	peptidase activity
NV385_09290	COG3300	MHYT domain
NV385_09290	COG5001	Diguanylate cyclase
NV385_09310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NV385_09310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NV385_09310	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
NV385_09315	COG1105	Belongs to the carbohydrate kinase PfkB family
NV385_09320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NV385_09320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NV385_09350	COG0024	Methionine aminopeptidase
NV385_09355	COG0583	DNA-binding transcription factor activity
NV385_09365	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NV385_09370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NV385_09375	COG0517	IMP dehydrogenase activity
NV385_09375	COG0516	GMP reductase activity
NV385_09400	COG0552	protein localization to endoplasmic reticulum
NV385_09410	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
NV385_09425	COG4890	Cyd operon protein YbgT
NV385_09430	COG1294	oxidase, subunit
NV385_09445	COG1585	Membrane protein implicated in regulation of membrane protease activity
NV385_09455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NV385_09460	COG4774	siderophore transport
NV385_09475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NV385_09480	COG0569	domain protein
NV385_09485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NV385_09515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NV385_09520	COG0542	response to heat
NV385_09545	COG0446	pyridine nucleotide-disulphide oxidoreductase
NV385_09545	COG1902	pentaerythritol trinitrate reductase activity
NV385_09590	COG2323	membrane
NV385_09595	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NV385_09605	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NV385_09610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NV385_09615	COG0183	Belongs to the thiolase family
NV385_09620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NV385_09625	COG0596	Alpha beta hydrolase
NV385_09630	COG2271	Major facilitator Superfamily
NV385_09635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NV385_09640	COG3485	protocatechuate 3,4-dioxygenase
NV385_09645	COG3485	protocatechuate 3,4-dioxygenase
NV385_09650	COG0710	3-dehydroquinate dehydratase activity
NV385_09655	COG3420	alginic acid biosynthetic process
NV385_09660	COG3659	wide pore channel activity
NV385_09665	COG4993	Dehydrogenase
NV385_09675	COG2391	methyltransferase activity
NV385_09690	COG1414	Transcriptional regulator
NV385_09695	COG0583	DNA-binding transcription factor activity
NV385_09700	COG1960	acyl-CoA dehydrogenase activity
NV385_09725	COG2814	Major facilitator Superfamily
NV385_09735	COG0154	amidase activity
NV385_09755	COG4638	Rieske (2fe-2S)
NV385_09765	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_09775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NV385_09785	COG3733	amine oxidase
NV385_09795	COG1012	belongs to the aldehyde dehydrogenase family
NV385_09805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NV385_09810	COG0183	Belongs to the thiolase family
NV385_09815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NV385_09820	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NV385_09830	COG4829	muconolactone delta-isomerase
NV385_09835	COG4948	Mandelate Racemase Muconate Lactonizing
NV385_09840	COG0583	DNA-binding transcription factor activity
NV385_09850	COG2186	Transcriptional regulator
NV385_09870	COG1012	belongs to the aldehyde dehydrogenase family
NV385_09890	COG1960	acyl-CoA dehydrogenase activity
NV385_09895	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_09900	COG3829	transcription factor binding
NV385_09910	COG3162	membrane
NV385_09925	COG1012	belongs to the aldehyde dehydrogenase family
NV385_09940	COG0753	catalase activity
NV385_09960	COG1846	Transcriptional regulator
NV385_09965	COG0446	pyridine nucleotide-disulphide oxidoreductase
NV385_09965	COG1902	pentaerythritol trinitrate reductase activity
NV385_09975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NV385_10005	COG1309	transcriptional regulator
NV385_10015	COG1335	isochorismatase
NV385_10020	COG0583	DNA-binding transcription factor activity
NV385_10030	COG0475	glutathione-regulated potassium exporter activity
NV385_10030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NV385_10040	COG1473	amidohydrolase
NV385_10050	COG2831	hemolysin activation secretion protein
NV385_10055	COG3210	domain, Protein
NV385_10085	COG2188	Transcriptional regulator
NV385_10100	COG0583	DNA-binding transcription factor activity
NV385_10130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NV385_10160	COG1566	PFAM secretion protein HlyD family protein
NV385_10175	COG1012	belongs to the aldehyde dehydrogenase family
NV385_10180	COG0129	dihydroxy-acid dehydratase activity
NV385_10190	COG0583	DNA-binding transcription factor activity
NV385_10195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NV385_10205	COG2084	Dehydrogenase
NV385_10210	COG2207	Transcriptional regulator
NV385_10225	COG1064	alcohol dehydrogenase
NV385_10235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NV385_10240	COG1120	ATPase activity
NV385_10260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NV385_10385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NV385_10435	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_10450	COG2207	Transcriptional regulator
NV385_10465	COG2205	protein histidine kinase activity
NV385_10470	COG0745	RESPONSE REGULATOR receiver
NV385_10475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NV385_10480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NV385_10485	COG1538	Outer membrane efflux protein
NV385_10495	COG2072	flavoprotein involved in K transport
NV385_10515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NV385_10535	COG3539	Fimbrial protein
NV385_10565	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NV385_10575	COG0753	catalase activity
NV385_10590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NV385_10650	COG1535	isochorismatase
NV385_10650	COG3433	isochorismatase activity
NV385_10655	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_10660	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NV385_10665	COG4149	molybdate abc transporter
NV385_10670	COG0725	ABC transporter, periplasmic molybdate-binding protein
NV385_10680	COG4638	Rieske (2fe-2S)
NV385_10685	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
NV385_10690	COG0543	2 iron, 2 sulfur cluster binding
NV385_10690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NV385_10715	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_10730	COG2207	Transcriptional regulator
NV385_10740	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_10745	COG2610	gluconate transmembrane transporter activity
NV385_10755	COG0583	DNA-binding transcription factor activity
NV385_10765	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NV385_10770	COG2031	fatty acid transporter
NV385_10775	COG0183	Belongs to the thiolase family
NV385_10780	COG0583	DNA-binding transcription factor activity
NV385_10785	COG0583	DNA-binding transcription factor activity
NV385_10800	COG1027	Aspartate ammonia-lyase
NV385_10810	COG0477	Major facilitator Superfamily
NV385_10830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NV385_10835	COG4521	taurine ABC transporter
NV385_10850	COG2188	Transcriptional regulator
NV385_10860	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NV385_10865	COG1733	regulation of RNA biosynthetic process
NV385_10870	COG2207	Transcriptional regulator
NV385_10870	COG3708	Transcriptional regulator
NV385_10885	COG0730	response to heat
NV385_10900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NV385_10900	COG3453	Protein conserved in bacteria
NV385_10910	COG3781	membrane
NV385_10915	COG1063	alcohol dehydrogenase
NV385_10925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NV385_10930	COG0508	dehydrogenase complex catalyzes the overall conversion of
NV385_10935	COG0022	dehydrogenase e1 component
NV385_10940	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NV385_10945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NV385_10960	COG3706	GGDEF domain
NV385_10975	COG0133	tryptophan synthase activity
NV385_10985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NV385_11020	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NV385_11045	COG2226	methyltransferase
NV385_11100	COG0842	Transport permease protein
NV385_11105	COG0842	Transport permease protein
NV385_11110	COG1131	(ABC) transporter
NV385_11125	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NV385_11130	COG4773	Receptor
NV385_11150	COG0730	response to heat
NV385_11155	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NV385_11175	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NV385_11190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NV385_11230	COG4264	IucA IucC family
NV385_11235	COG4264	IucA IucC family
NV385_11255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NV385_11270	COG1960	acyl-CoA dehydrogenase activity
NV385_11275	COG1960	acyl-CoA dehydrogenase activity
NV385_11280	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NV385_11285	COG2207	Transcriptional regulator
NV385_11290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NV385_11295	COG0776	regulation of translation
NV385_11320	COG0822	iron-sulfur transferase activity
NV385_11325	COG0316	Belongs to the HesB IscA family
NV385_11355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NV385_11385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NV385_11390	COG0702	epimerase
NV385_11425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NV385_11435	COG0339	signal peptide processing
NV385_11485	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NV385_11490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NV385_11520	COG0776	regulation of translation
NV385_11585	COG0084	hydrolase, TatD family'
NV385_11605	COG1663	tetraacyldisaccharide 4'-kinase activity
NV385_11610	COG1132	(ABC) transporter
NV385_11620	COG0811	peptide transport
NV385_11625	COG1475	DNA binding
NV385_11630	COG1192	Involved in chromosome partitioning
NV385_11640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NV385_11655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NV385_11660	COG0191	fructose-bisphosphate aldolase activity
NV385_11680	COG0424	maF-like protein
NV385_11685	COG2850	peptidyl-arginine hydroxylation
NV385_11695	COG0640	Transcriptional regulator
NV385_11705	COG3619	membrane
NV385_11710	COG3122	Protein conserved in bacteria
NV385_11715	COG1132	(ABC) transporter
NV385_11735	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NV385_11740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NV385_11750	COG0506	proline dehydrogenase activity
NV385_11750	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NV385_11750	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NV385_11755	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NV385_11770	COG3698	Phosphodiester glycosidase
NV385_11780	COG2353	YceI-like domain
NV385_11790	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NV385_11835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NV385_11835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NV385_11860	COG3539	Fimbrial protein
NV385_11865	COG3121	Chaperone
NV385_11890	COG0697	spore germination
NV385_11900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NV385_11910	COG0583	DNA-binding transcription factor activity
NV385_11930	COG1309	transcriptional regulator
NV385_11945	COG1522	sequence-specific DNA binding
NV385_11960	COG1126	abc transporter atp-binding protein
NV385_11965	COG0765	amino acid transport
NV385_11970	COG0765	amino acid transport
NV385_12000	COG1464	Belongs to the NlpA lipoprotein family
NV385_12010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NV385_12015	COG2011	ABC-type metal ion transport system permease component
NV385_12020	COG0012	GTP binding
NV385_12045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NV385_12085	COG0386	Belongs to the glutathione peroxidase family
NV385_12095	COG0436	Aminotransferase
NV385_12135	COG3634	alkyl hydroperoxide reductase activity
NV385_12150	COG0583	DNA-binding transcription factor activity
NV385_12155	COG0798	PFAM Bile acid sodium symporter
NV385_12160	COG0640	Transcriptional regulator
NV385_12175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NV385_12185	COG0583	DNA-binding transcription factor activity
NV385_12195	COG1953	Uracil, thiamine, allantoin
NV385_12205	COG2175	clavaminate synthase activity
NV385_12210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NV385_12215	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
NV385_12220	COG4521	taurine ABC transporter
NV385_12230	COG0477	Major facilitator Superfamily
NV385_12250	COG1271	oxidase subunit
NV385_12255	COG1294	oxidase, subunit
NV385_12265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NV385_12285	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NV385_12305	COG3052	prosthetic group binding
NV385_12310	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
NV385_12320	COG2814	Major facilitator Superfamily
NV385_12340	COG1346	cytolysis
NV385_12350	COG0583	DNA-binding transcription factor activity
NV385_12355	COG0625	glutathione transferase activity
NV385_12360	COG0625	glutathione transferase activity
NV385_12365	COG0583	DNA-binding transcription factor activity
NV385_12380	COG1045	serine acetyltransferase
NV385_12385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NV385_12390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NV385_12400	COG1280	lysine exporter protein (LysE YggA)
NV385_12415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NV385_12420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NV385_12425	COG1126	abc transporter atp-binding protein
NV385_12430	COG0765	amino acid transport
NV385_12435	COG0765	amino acid transport
NV385_12455	COG0784	Response regulator, receiver
NV385_12455	COG2205	protein histidine kinase activity
NV385_12475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NV385_12495	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_12545	COG0583	DNA-binding transcription factor activity
NV385_12570	COG0318	PFAM AMP-dependent synthetase and ligase
NV385_12575	COG1309	transcriptional regulator
NV385_12580	COG1960	acyl-CoA dehydrogenase activity
NV385_12585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NV385_12590	COG1024	Enoyl-CoA hydratase
NV385_12595	COG4770	biotin carboxylase activity
NV385_12605	COG0583	DNA-binding transcription factor activity
NV385_12620	COG1960	acyl-CoA dehydrogenase activity
NV385_12630	COG2814	Major facilitator Superfamily
NV385_12640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NV385_12645	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NV385_12650	COG2814	Major facilitator Superfamily
NV385_12655	COG1960	acyl-CoA dehydrogenase activity
NV385_12660	COG1024	Enoyl-CoA hydratase
NV385_12665	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_12670	COG1250	3-hydroxyacyl-CoA dehydrogenase
NV385_12675	COG0183	Belongs to the thiolase family
NV385_12685	COG2814	Major facilitator Superfamily
NV385_12695	COG1024	Enoyl-CoA hydratase
NV385_12710	COG1960	acyl-CoA dehydrogenase activity
NV385_12715	COG2814	Major facilitator Superfamily
NV385_12720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NV385_12725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NV385_12740	COG3842	ATPase activity
NV385_12745	COG1840	ABC-type Fe3 transport system, periplasmic component
NV385_12755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NV385_12760	COG1414	Transcriptional regulator
NV385_12770	COG0583	DNA-binding transcription factor activity
NV385_12775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NV385_12780	COG1012	belongs to the aldehyde dehydrogenase family
NV385_12790	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NV385_12800	COG1012	belongs to the aldehyde dehydrogenase family
NV385_12805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NV385_12810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NV385_12815	COG2267	carboxylic ester hydrolase activity
NV385_12830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NV385_12880	COG1012	belongs to the aldehyde dehydrogenase family
NV385_12900	COG0531	amino acid
NV385_12910	COG1113	amino acid transport
NV385_12950	COG3209	COG3209 Rhs family protein
NV385_12980	COG4269	membrane
NV385_12995	COG1902	pentaerythritol trinitrate reductase activity
NV385_12995	COG0446	pyridine nucleotide-disulphide oxidoreductase
NV385_13005	COG3706	GGDEF domain
NV385_13005	COG4251	negative regulation of phosphorylation
NV385_13005	COG5001	Diguanylate cyclase
NV385_13005	COG2203	Gaf domain
NV385_13015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NV385_13035	COG4172	Belongs to the ABC transporter superfamily
NV385_13040	COG4239	(ABC) transporter, permease
NV385_13045	COG4174	ABC transporter (Permease)
NV385_13055	COG0741	lytic transglycosylase activity
NV385_13055	COG1388	LysM domain
NV385_13055	COG1388	LysM domain
NV385_13055	COG0741	lytic transglycosylase activity
NV385_13060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NV385_13100	COG0583	DNA-binding transcription factor activity
NV385_13105	COG1279	arginine transmembrane transporter activity
NV385_13125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NV385_13130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NV385_13135	COG0006	proline dipeptidase activity
NV385_13175	COG2194	sulfuric ester hydrolase activity
NV385_13220	COG0739	heme binding
NV385_13545	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NV385_13570	COG3384	dioxygenase
NV385_13580	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NV385_13585	COG2878	Part of a membrane complex involved in electron transport
NV385_13590	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NV385_13615	COG0768	penicillin binding
NV385_13620	COG0742	ribosomal rna small subunit methyltransferase
NV385_13635	COG0830	nickel cation binding
NV385_13645	COG0804	urea catabolic process
NV385_13685	COG1253	flavin adenine dinucleotide binding
NV385_13690	COG2851	Citrate transporter
NV385_13740	COG1773	rubredoxin
NV385_13745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NV385_13755	COG0583	DNA-binding transcription factor activity
NV385_13780	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NV385_13785	COG4181	ATPase activity
NV385_13830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NV385_13850	COG0306	phosphate transporter
NV385_13860	COG3958	Transketolase
NV385_13865	COG3959	Transketolase, thiamine diphosphate binding domain
NV385_13870	COG2271	Major facilitator Superfamily
NV385_13875	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_13880	COG0583	DNA-binding transcription factor activity
NV385_13895	COG2223	nitrite transmembrane transporter activity
NV385_13900	COG2207	Transcriptional regulator
NV385_13905	COG2066	Belongs to the glutaminase family
NV385_13910	COG0242	peptide deformylase activity
NV385_13915	COG0477	Major facilitator Superfamily
NV385_13925	COG0028	Belongs to the TPP enzyme family
NV385_13940	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_13945	COG2267	carboxylic ester hydrolase activity
NV385_13955	COG2271	Major facilitator Superfamily
NV385_13960	COG0446	pyridine nucleotide-disulphide oxidoreductase
NV385_13970	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_13990	COG1414	Transcriptional regulator
NV385_14005	COG1024	Enoyl-CoA hydratase
NV385_14015	COG1215	transferase activity, transferring glycosyl groups
NV385_14020	COG0726	polysaccharide deacetylase
NV385_14020	COG1649	PFAM Uncharacterised BCR, COG1649
NV385_14030	COG4681	YaeQ
NV385_14040	COG0523	cobalamin synthesis protein
NV385_14050	COG1607	acyl-coa hydrolase
NV385_14060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NV385_14065	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NV385_14070	COG1309	transcriptional regulator
NV385_14095	COG2040	homocysteine
NV385_14100	COG0531	amino acid
NV385_14155	COG1595	DNA-templated transcription, initiation
NV385_14165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NV385_14170	COG0477	Major facilitator Superfamily
NV385_14190	COG0084	hydrolase, TatD family'
NV385_14225	COG0629	single-stranded DNA binding
NV385_14280	COG0582	viral genome integration into host DNA
NV385_14310	COG1061	Type III restriction enzyme res subunit
NV385_14320	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NV385_14325	COG1192	Involved in chromosome partitioning
NV385_14335	COG1061	Type III restriction enzyme res subunit
NV385_14425	COG2026	Addiction module toxin, RelE StbE family
NV385_14575	COG3755	Protein conserved in bacteria
NV385_14620	COG1484	DNA-dependent DNA replication
NV385_14710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NV385_14780	COG0405	Gamma-glutamyltransferase
NV385_14785	COG2814	Major facilitator Superfamily
NV385_14795	COG2050	protein possibly involved in aromatic compounds catabolism
NV385_14810	COG1090	epimerase
NV385_14830	COG0420	3'-5' exonuclease activity
NV385_14855	COG0735	belongs to the Fur family
NV385_14860	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NV385_14880	COG0121	glutamine amidotransferase
NV385_14895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NV385_14905	COG0210	DNA helicase
NV385_14910	COG2885	chlorophyll binding
NV385_14915	COG0204	Acyl-transferase
NV385_14930	COG2894	cell division
NV385_14955	COG1280	lysine exporter protein (LysE YggA)
NV385_14960	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NV385_14960	COG1674	ftsk spoiiie
NV385_14965	COG0492	ferredoxin-NADP+ reductase activity
NV385_14970	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NV385_14980	COG0456	acetyltransferase
NV385_15025	COG1981	membrane
NV385_15040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NV385_15040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NV385_15060	COG1012	belongs to the aldehyde dehydrogenase family
NV385_15070	COG0657	acetylesterase activity
NV385_15080	COG0473	3-isopropylmalate dehydrogenase activity
NV385_15085	COG0583	DNA-binding transcription factor activity
NV385_15105	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NV385_15130	COG0564	pseudouridine synthase activity
NV385_15140	COG0358	DNA primase activity
NV385_15155	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
NV385_15185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NV385_15215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NV385_15225	COG0351	phosphomethylpyrimidine kinase
NV385_15225	COG0352	thiamine-phosphate diphosphorylase activity
NV385_15225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NV385_15230	COG1652	LysM domain
NV385_15255	COG1399	metal-binding, possibly nucleic acid-binding protein
NV385_15260	COG3101	peptidyl-lysine hydroxylation
NV385_15265	COG0009	L-threonylcarbamoyladenylate synthase
NV385_15270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NV385_15275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NV385_15290	COG4106	trans-aconitate 2-methyltransferase activity
NV385_15305	COG2226	methyltransferase
NV385_15305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NV385_15305	COG0596	Alpha beta hydrolase
NV385_15310	COG1877	trehalose-phosphatase activity
NV385_15315	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NV385_15320	COG2223	nitrite transmembrane transporter activity
NV385_15340	COG1196	nuclear chromosome segregation
NV385_15350	COG0730	response to heat
NV385_15365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NV385_15375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NV385_15435	COG0489	protein tyrosine kinase activity
NV385_15445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NV385_15445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NV385_15475	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NV385_15480	COG2081	HI0933 family
NV385_15490	COG0668	transmembrane transport
NV385_15510	COG0583	DNA-binding transcription factor activity
NV385_15530	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NV385_15535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NV385_15565	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NV385_15605	COG0745	RESPONSE REGULATOR receiver
NV385_15625	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NV385_15635	COG2205	protein histidine kinase activity
NV385_15705	COG4993	Dehydrogenase
NV385_15730	COG0384	phenazine biosynthesis protein PhzF
NV385_15755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NV385_15770	COG0583	DNA-binding transcription factor activity
NV385_15800	COG0583	DNA-binding transcription factor activity
NV385_15815	COG0583	DNA-binding transcription factor activity
NV385_15820	COG1053	succinate dehydrogenase
NV385_15830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NV385_15835	COG2814	Major facilitator Superfamily
NV385_15840	COG1960	acyl-CoA dehydrogenase activity
NV385_15845	COG0583	DNA-binding transcription factor activity
NV385_15850	COG1063	alcohol dehydrogenase
NV385_15880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NV385_15885	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NV385_15890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NV385_15905	COG3667	copper resistance
NV385_15910	COG2132	Multicopper oxidase
NV385_15920	COG0561	phosphatase activity
NV385_15925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NV385_15950	COG1214	PFAM Peptidase M22, glycoprotease
NV385_16000	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NV385_16010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NV385_16015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NV385_16020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NV385_16080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NV385_16090	COG1846	Transcriptional regulator
NV385_16095	COG1764	response to oxidative stress
NV385_16135	COG0037	tRNA processing
NV385_16145	COG0248	Ppx GppA phosphatase
NV385_16175	COG0072	phenylalanine-tRNA ligase activity
NV385_16220	COG1238	metal cluster binding
NV385_16225	COG0625	glutathione transferase activity
NV385_16240	COG0318	PFAM AMP-dependent synthetase and ligase
NV385_16245	COG3028	Belongs to the UPF0307 family
NV385_16250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NV385_16270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NV385_16275	COG0617	tRNA 3'-terminal CCA addition
NV385_16280	COG1555	photosystem II stabilization
NV385_16285	COG3956	TIGRFAM MazG family protein
NV385_16295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NV385_16315	COG5002	protein histidine kinase activity
NV385_16315	COG2205	protein histidine kinase activity
NV385_16315	COG0784	Response regulator, receiver
NV385_16320	COG1024	Enoyl-CoA hydratase
NV385_16325	COG2084	Dehydrogenase
NV385_16330	COG3622	Belongs to the hyi family
NV385_16360	COG0697	spore germination
NV385_16370	COG2814	Major facilitator Superfamily
NV385_16375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NV385_16385	COG0583	DNA-binding transcription factor activity
NV385_16395	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NV385_16410	COG0084	hydrolase, TatD family'
NV385_16425	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NV385_16455	COG0440	acetolactate synthase activity
NV385_16460	COG0028	Belongs to the TPP enzyme family
NV385_16485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NV385_16490	COG1136	(ABC) transporter
NV385_16490	COG0577	efflux transmembrane transporter activity
NV385_16495	COG1538	Outer membrane efflux protein
NV385_16510	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NV385_16515	COG1162	GTPase activity
NV385_16525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NV385_16545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NV385_16550	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_16590	COG2986	histidine ammonia-lyase
NV385_16605	COG0318	PFAM AMP-dependent synthetase and ligase
NV385_16615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NV385_16660	COG1426	Protein conserved in bacteria
NV385_16695	COG0793	Belongs to the peptidase S41A family
NV385_16710	COG2267	carboxylic ester hydrolase activity
NV385_16720	COG1012	belongs to the aldehyde dehydrogenase family
NV385_16725	COG3265	gluconokinase activity
NV385_16735	COG0800	Aldolase
NV385_16745	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NV385_16750	COG0280	phosphate acetyltransferase
NV385_16750	COG0857	belongs to the CobB CobQ family
NV385_16755	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
NV385_16755	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
NV385_16775	COG0740	serine-type endopeptidase activity
NV385_16785	COG4774	siderophore transport
NV385_16795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NV385_16805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NV385_16805	COG2813	Specifically methylates the guanine in position
NV385_16905	COG0788	formyltetrahydrofolate deformylase activity
NV385_16930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NV385_16930	COG4651	solute:proton antiporter activity
NV385_16950	COG0724	RNA recognition motif
NV385_16955	COG0210	DNA helicase
NV385_16980	COG1733	regulation of RNA biosynthetic process
NV385_16990	COG2900	Belongs to the SlyX family
NV385_16995	COG0488	(ABC) transporter
NV385_17000	COG1280	lysine exporter protein (LysE YggA)
NV385_17005	COG1560	Kdo2-lipid A biosynthetic process
NV385_17015	COG1301	dicarboxylic acid transport
NV385_17070	COG0473	3-isopropylmalate dehydrogenase activity
NV385_17105	COG3328	transposase activity
NV385_17140	COG0583	DNA-binding transcription factor activity
NV385_17150	COG0625	glutathione transferase activity
NV385_17155	COG2378	regulation of single-species biofilm formation
NV385_17160	COG0546	phosphoglycolate phosphatase activity
NV385_17170	COG1530	ribonuclease E activity
NV385_17175	COG0318	PFAM AMP-dependent synthetase and ligase
NV385_17190	COG0583	DNA-binding transcription factor activity
NV385_17195	COG4221	oxidoreductase activity
NV385_17200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NV385_17210	COG0534	Mate efflux family protein
NV385_17225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NV385_17265	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
NV385_17270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NV385_17285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NV385_17295	COG0644	oxidoreductase
NV385_17295	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
NV385_17300	COG0425	Belongs to the sulfur carrier protein TusA family
NV385_17305	COG4535	Mg2 and Co2 transporter CorC
NV385_17315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NV385_17335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NV385_17340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NV385_17340	COG0475	glutathione-regulated potassium exporter activity
NV385_17345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NV385_17355	COG0484	heat shock protein binding
NV385_17360	COG0789	Transcriptional regulator
NV385_17365	COG0598	Magnesium transport protein CorA
NV385_17380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NV385_17385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NV385_17390	COG1074	ATP-dependent DNA helicase activity
NV385_17395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NV385_17415	COG2226	methyltransferase
NV385_17430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NV385_17435	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NV385_17450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NV385_17450	COG2111	Na H antiporter
NV385_17455	COG1006	Multisubunit Na H antiporter MnhC subunit
NV385_17460	COG0651	ATP synthesis coupled electron transport
NV385_17465	COG1863	multisubunit Na H antiporter MnhE subunit
NV385_17470	COG2212	antiporter activity
NV385_17475	COG1320	monovalent cation:proton antiporter activity
NV385_17490	COG0195	Participates in both transcription termination and antitermination
NV385_17540	COG0237	dephospho-CoA kinase activity
NV385_17550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NV385_17565	COG0497	DNA recombination
NV385_17575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NV385_17605	COG2169	Transcriptional regulator
NV385_17605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NV385_17610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NV385_17675	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NV385_17690	COG0326	Molecular chaperone. Has ATPase activity
NV385_17705	COG2056	Na+-H+ antiporter family
NV385_17710	COG0596	Alpha beta hydrolase
NV385_17805	COG0546	phosphoglycolate phosphatase activity
NV385_17810	COG1716	ATPase activity
NV385_17855	COG0181	hydroxymethylbilane synthase activity
NV385_17865	COG3275	phosphorelay sensor kinase activity
NV385_17885	COG1538	Outer membrane efflux protein
NV385_17890	COG0697	spore germination
NV385_17915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NV385_17920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NV385_17925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NV385_17930	COG0772	Belongs to the SEDS family
NV385_17955	COG4974	Belongs to the 'phage' integrase family
NV385_17960	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NV385_17970	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NV385_17980	COG2197	response regulator
NV385_17995	COG0793	Belongs to the peptidase S41A family
NV385_18000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NV385_18005	COG0795	lipopolysaccharide-transporting ATPase activity
NV385_18045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NV385_18045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NV385_18055	COG0004	ammonium transporteR
NV385_18060	COG0347	Belongs to the P(II) protein family
NV385_18120	COG0659	secondary active sulfate transmembrane transporter activity
NV385_18125	COG0589	response to stress
NV385_18160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NV385_18170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NV385_18190	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NV385_18205	COG0318	PFAM AMP-dependent synthetase and ligase
NV385_18215	COG0477	Major facilitator Superfamily
NV385_18220	COG2860	membrane
NV385_18230	COG1253	flavin adenine dinucleotide binding
NV385_18250	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NV385_18290	COG0655	NAD(P)H dehydrogenase (quinone) activity
NV385_18300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NV385_18370	COG0758	DNA mediated transformation
NV385_18380	COG0697	spore germination
NV385_18385	COG1309	transcriptional regulator
NV385_18400	COG0386	Belongs to the glutathione peroxidase family
NV385_18465	COG1121	(ABC) transporter
NV385_18470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NV385_18475	COG1280	lysine exporter protein (LysE YggA)
NV385_18480	COG2837	iron assimilation
NV385_18490	COG0281	malic enzyme
NV385_18535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NV385_18535	COG0519	Catalyzes the synthesis of GMP from XMP
NV385_18540	COG4399	Belongs to the UPF0754 family
NV385_18545	COG2259	Doxx family
NV385_18550	COG0586	Pfam SNARE associated Golgi protein
NV385_18565	COG1192	Involved in chromosome partitioning
NV385_18575	COG0271	Belongs to the BolA IbaG family
NV385_18595	COG2267	carboxylic ester hydrolase activity
NV385_18615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NV385_18615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NV385_18615	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NV385_18615	COG3321	synthase
NV385_18620	COG1960	acyl-CoA dehydrogenase activity
NV385_18630	COG2197	response regulator
NV385_18640	COG3916	Acyl-homoserine-lactone synthase
NV385_18645	COG0477	Major facilitator Superfamily
NV385_18650	COG1024	Enoyl-CoA hydratase
NV385_18655	COG1024	Enoyl-CoA hydratase
NV385_18660	COG1960	acyl-CoA dehydrogenase activity
NV385_18665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NV385_18685	COG1113	amino acid transport
NV385_18690	COG1113	amino acid transport
NV385_18695	COG0251	oxidation-reduction process
NV385_18735	COG0564	pseudouridine synthase activity
NV385_18795	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NV385_18810	COG1802	Transcriptional regulator
NV385_18820	COG1448	Aminotransferase
NV385_18825	COG0277	FAD linked oxidase domain protein
NV385_18835	COG2186	Transcriptional regulator
NV385_18845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NV385_18850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NV385_18865	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NV385_18870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NV385_18875	COG1216	Glycosyl transferase, family 2
NV385_18905	COG2089	acid synthase
NV385_18920	COG1083	cytidylyl-transferase
NV385_18925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NV385_18930	COG1086	Polysaccharide biosynthesis protein
NV385_18935	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NV385_18940	COG1596	polysaccharide export
NV385_18965	COG0728	peptidoglycan biosynthetic process
NV385_18970	COG3023	N-Acetylmuramoyl-L-alanine amidase
NV385_19030	COG0546	phosphoglycolate phosphatase activity
NV385_19035	COG1028	Short-chain dehydrogenase reductase Sdr
NV385_19055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NV385_19060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NV385_19065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NV385_19070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NV385_19075	COG1116	anion transmembrane transporter activity
NV385_19080	COG1309	transcriptional regulator
NV385_19085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NV385_19095	COG0196	riboflavin kinase activity
NV385_19100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NV385_19110	COG1047	Peptidyl-prolyl cis-trans
NV385_19150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NV385_19155	COG0657	acetylesterase activity
NV385_19175	COG0583	DNA-binding transcription factor activity
NV385_19205	COG2951	lytic endotransglycosylase activity
NV385_19210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NV385_19225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NV385_19235	COG0671	phosphoesterase, PA-phosphatase related
NV385_19240	COG0861	Integral membrane protein TerC family
NV385_19250	COG0754	glutathionylspermidine amidase activity
NV385_19260	COG0402	S-adenosylhomocysteine deaminase activity
NV385_19275	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NV385_19280	COG1230	cation diffusion facilitator family transporter
NV385_19295	COG0706	membrane insertase activity
NV385_19370	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
NV385_19435	COG4683	PFAM Phage derived protein Gp49-like (DUF891)