locus-tag	class	description
L2Z05_00040	COG1960	acyl-CoA dehydrogenase activity
L2Z05_00045	COG1309	transcriptional regulator
L2Z05_00060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z05_00065	COG1960	acyl-CoA dehydrogenase activity
L2Z05_00085	COG2969	positive regulation of protein catabolic process
L2Z05_00095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2Z05_00105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L2Z05_00110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2Z05_00115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2Z05_00135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2Z05_00145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z05_00150	COG1408	metallophosphoesterase
L2Z05_00160	COG2199	diguanylate cyclase activity
L2Z05_00220	COG1607	acyl-coa hydrolase
L2Z05_00250	COG2350	Protein conserved in bacteria
L2Z05_00260	COG0613	PHP domain protein
L2Z05_00265	COG3781	membrane
L2Z05_00275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2Z05_00280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2Z05_00290	COG1862	Preprotein translocase
L2Z05_00320	COG2205	protein histidine kinase activity
L2Z05_00325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2Z05_00345	COG0726	polysaccharide deacetylase
L2Z05_00350	COG0463	Glycosyl transferase, family 2
L2Z05_00355	COG0438	transferase activity, transferring glycosyl groups
L2Z05_00420	COG1960	acyl-CoA dehydrogenase activity
L2Z05_00425	COG1960	acyl-CoA dehydrogenase activity
L2Z05_00435	COG2205	protein histidine kinase activity
L2Z05_00440	COG0745	RESPONSE REGULATOR receiver
L2Z05_00445	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2Z05_00465	COG2096	Adenosyltransferase
L2Z05_00515	COG0285	dihydrofolate synthase activity
L2Z05_00535	COG0450	alkyl hydroperoxide reductase
L2Z05_00550	COG0477	Major facilitator Superfamily
L2Z05_00555	COG1272	protein, Hemolysin III
L2Z05_00585	COG0183	Belongs to the thiolase family
L2Z05_00590	COG2207	Transcriptional regulator
L2Z05_00610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z05_00630	COG0183	Belongs to the thiolase family
L2Z05_00640	COG2885	chlorophyll binding
L2Z05_00640	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2Z05_00650	COG1690	Belongs to the RtcB family
L2Z05_00655	COG0833	amino acid
L2Z05_00665	COG2233	PERMEase
L2Z05_00670	COG1217	gtp-binding protein TYPA
L2Z05_00695	COG2094	Belongs to the DNA glycosylase MPG family
L2Z05_00705	COG1902	pentaerythritol trinitrate reductase activity
L2Z05_00720	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z05_00725	COG0354	folic acid binding
L2Z05_00735	COG3189	MarR family transcriptional regulator
L2Z05_00740	COG2824	Alkylphosphonate utilization operon protein PhnA
L2Z05_00745	COG3422	double-strand break repair
L2Z05_00785	COG0840	transmembrane signaling receptor activity
L2Z05_00805	COG5510	response to toxic substance
L2Z05_00815	COG2832	Protein of unknown function (DUF454)
L2Z05_00820	COG1376	ErfK ybiS ycfS ynhG family protein
L2Z05_00860	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2Z05_00870	COG1289	transmembrane transporter activity
L2Z05_00875	COG2814	Major facilitator Superfamily
L2Z05_00895	COG1115	amino acid carrier protein
L2Z05_00900	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z05_00905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z05_00910	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2Z05_00935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z05_00945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2Z05_00950	COG1077	Cell shape determining protein MreB Mrl
L2Z05_00955	COG1792	Involved in formation and maintenance of cell shape
L2Z05_00960	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2Z05_00965	COG0424	maF-like protein
L2Z05_00970	COG1530	ribonuclease E activity
L2Z05_00980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z05_00990	COG0560	Phosphoserine phosphatase
L2Z05_01000	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z05_01025	COG2207	Transcriptional regulator
L2Z05_01060	COG2963	transposase activity
L2Z05_01070	COG4372	Transposase
L2Z05_01100	COG1214	PFAM Peptidase M22, glycoprotease
L2Z05_01125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2Z05_01130	COG0561	phosphatase activity
L2Z05_01140	COG2132	Multicopper oxidase
L2Z05_01160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z05_01165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2Z05_01170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2Z05_01200	COG1063	alcohol dehydrogenase
L2Z05_01205	COG0583	DNA-binding transcription factor activity
L2Z05_01210	COG1960	acyl-CoA dehydrogenase activity
L2Z05_01215	COG2814	Major facilitator Superfamily
L2Z05_01220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z05_01225	COG1309	transcriptional regulator
L2Z05_01240	COG1053	succinate dehydrogenase
L2Z05_01245	COG0583	DNA-binding transcription factor activity
L2Z05_01260	COG0583	DNA-binding transcription factor activity
L2Z05_01270	COG0583	DNA-binding transcription factor activity
L2Z05_01285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z05_01340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2Z05_01360	COG0745	RESPONSE REGULATOR receiver
L2Z05_01375	COG3706	GGDEF domain
L2Z05_01400	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2Z05_01430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z05_01435	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2Z05_01460	COG0583	DNA-binding transcription factor activity
L2Z05_01480	COG0668	transmembrane transport
L2Z05_01490	COG2081	HI0933 family
L2Z05_01495	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2Z05_01525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z05_01525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z05_01535	COG0489	protein tyrosine kinase activity
L2Z05_01585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z05_01595	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2Z05_01610	COG0730	response to heat
L2Z05_01620	COG1196	nuclear chromosome segregation
L2Z05_01640	COG2223	nitrite transmembrane transporter activity
L2Z05_01645	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2Z05_01655	COG2226	methyltransferase
L2Z05_01655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z05_01655	COG0596	Alpha beta hydrolase
L2Z05_01670	COG4106	trans-aconitate 2-methyltransferase activity
L2Z05_01685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2Z05_01690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2Z05_01695	COG0009	L-threonylcarbamoyladenylate synthase
L2Z05_01700	COG3101	peptidyl-lysine hydroxylation
L2Z05_01705	COG1399	metal-binding, possibly nucleic acid-binding protein
L2Z05_01730	COG1652	LysM domain
L2Z05_01735	COG0351	phosphomethylpyrimidine kinase
L2Z05_01735	COG0352	thiamine-phosphate diphosphorylase activity
L2Z05_01735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z05_01745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2Z05_01775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z05_01805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2Z05_01820	COG0358	DNA primase activity
L2Z05_01830	COG0564	pseudouridine synthase activity
L2Z05_01855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z05_01875	COG0583	DNA-binding transcription factor activity
L2Z05_01880	COG0473	3-isopropylmalate dehydrogenase activity
L2Z05_01890	COG0657	acetylesterase activity
L2Z05_01900	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_01920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2Z05_01920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z05_01935	COG1981	membrane
L2Z05_01980	COG0456	acetyltransferase
L2Z05_01990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2Z05_01995	COG0492	ferredoxin-NADP+ reductase activity
L2Z05_02000	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2Z05_02000	COG1674	ftsk spoiiie
L2Z05_02005	COG1280	lysine exporter protein (LysE YggA)
L2Z05_02020	COG2894	cell division
L2Z05_02035	COG0204	Acyl-transferase
L2Z05_02040	COG2885	chlorophyll binding
L2Z05_02045	COG0210	DNA helicase
L2Z05_02055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z05_02070	COG0121	glutamine amidotransferase
L2Z05_02090	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2Z05_02095	COG0735	belongs to the Fur family
L2Z05_02120	COG0420	3'-5' exonuclease activity
L2Z05_02140	COG1090	epimerase
L2Z05_02155	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z05_02165	COG2814	Major facilitator Superfamily
L2Z05_02180	COG0582	viral genome integration into host DNA
L2Z05_02225	COG0629	single-stranded DNA binding
L2Z05_02265	COG4372	Transposase
L2Z05_02275	COG2963	transposase activity
L2Z05_02280	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
L2Z05_02295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
L2Z05_02335	COG0477	Major facilitator Superfamily
L2Z05_02350	COG1595	DNA-templated transcription, initiation
L2Z05_02405	COG0531	amino acid
L2Z05_02410	COG2040	homocysteine
L2Z05_02435	COG1309	transcriptional regulator
L2Z05_02440	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z05_02445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z05_02455	COG1607	acyl-coa hydrolase
L2Z05_02465	COG0523	cobalamin synthesis protein
L2Z05_02475	COG4681	YaeQ
L2Z05_02485	COG0726	polysaccharide deacetylase
L2Z05_02485	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z05_02490	COG1215	transferase activity, transferring glycosyl groups
L2Z05_02500	COG1024	Enoyl-CoA hydratase
L2Z05_02515	COG1414	Transcriptional regulator
L2Z05_02535	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_02550	COG2271	Major facilitator Superfamily
L2Z05_02560	COG2267	carboxylic ester hydrolase activity
L2Z05_02565	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_02580	COG0028	Belongs to the TPP enzyme family
L2Z05_02590	COG0477	Major facilitator Superfamily
L2Z05_02595	COG0242	peptide deformylase activity
L2Z05_02600	COG2066	Belongs to the glutaminase family
L2Z05_02605	COG2207	Transcriptional regulator
L2Z05_02610	COG2223	nitrite transmembrane transporter activity
L2Z05_02625	COG0583	DNA-binding transcription factor activity
L2Z05_02630	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_02635	COG2271	Major facilitator Superfamily
L2Z05_02640	COG3959	Transketolase, thiamine diphosphate binding domain
L2Z05_02645	COG3958	Transketolase
L2Z05_02655	COG0306	phosphate transporter
L2Z05_02675	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z05_02720	COG4181	ATPase activity
L2Z05_02725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2Z05_02755	COG0583	DNA-binding transcription factor activity
L2Z05_02765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z05_02770	COG1773	rubredoxin
L2Z05_02820	COG2851	Citrate transporter
L2Z05_02825	COG1253	flavin adenine dinucleotide binding
L2Z05_02865	COG0804	urea catabolic process
L2Z05_02875	COG0830	nickel cation binding
L2Z05_02890	COG0742	ribosomal rna small subunit methyltransferase
L2Z05_02895	COG0768	penicillin binding
L2Z05_02920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2Z05_02925	COG2878	Part of a membrane complex involved in electron transport
L2Z05_02930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z05_02940	COG3384	dioxygenase
L2Z05_02965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2Z05_03260	COG0739	heme binding
L2Z05_03260	COG0741	lytic transglycosylase activity
L2Z05_03260	COG1196	nuclear chromosome segregation
L2Z05_03350	COG0006	proline dipeptidase activity
L2Z05_03355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z05_03360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z05_03380	COG1279	arginine transmembrane transporter activity
L2Z05_03385	COG0583	DNA-binding transcription factor activity
L2Z05_03425	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z05_03430	COG0741	lytic transglycosylase activity
L2Z05_03430	COG1388	LysM domain
L2Z05_03430	COG1388	LysM domain
L2Z05_03430	COG0741	lytic transglycosylase activity
L2Z05_03440	COG4174	ABC transporter (Permease)
L2Z05_03445	COG4239	(ABC) transporter, permease
L2Z05_03450	COG4172	Belongs to the ABC transporter superfamily
L2Z05_03470	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2Z05_03480	COG3706	GGDEF domain
L2Z05_03480	COG4251	negative regulation of phosphorylation
L2Z05_03480	COG5001	Diguanylate cyclase
L2Z05_03480	COG2203	Gaf domain
L2Z05_03490	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z05_03490	COG1902	pentaerythritol trinitrate reductase activity
L2Z05_03505	COG4269	membrane
L2Z05_03550	COG1113	amino acid transport
L2Z05_03560	COG0531	amino acid
L2Z05_03580	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_03600	COG1113	amino acid transport
L2Z05_03615	COG0697	spore germination
L2Z05_03620	COG2721	sulfolactate sulfo-lyase activity
L2Z05_03625	COG2271	Major facilitator Superfamily
L2Z05_03630	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z05_03640	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_03645	COG2186	Transcriptional regulator
L2Z05_03670	COG1960	acyl-CoA dehydrogenase activity
L2Z05_03680	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_03685	COG1024	Enoyl-CoA hydratase
L2Z05_03690	COG2814	Major facilitator Superfamily
L2Z05_03705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z05_03720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2Z05_03770	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L2Z05_03775	COG2072	flavoprotein involved in K transport
L2Z05_03780	COG0300	oxidoreductase activity
L2Z05_03790	COG1309	transcriptional regulator
L2Z05_03795	COG1741	Belongs to the pirin family
L2Z05_03810	COG2072	flavoprotein involved in K transport
L2Z05_03820	COG2252	PERMEase
L2Z05_03825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2Z05_03830	COG3038	cytochrome b561
L2Z05_03840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2Z05_03850	COG0527	aspartate kinase activity
L2Z05_03860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2Z05_03875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2Z05_03890	COG0667	Aldo Keto reductase
L2Z05_03905	COG1765	OsmC-like protein
L2Z05_03920	COG0542	response to heat
L2Z05_03955	COG2885	chlorophyll binding
L2Z05_03965	COG0625	glutathione transferase activity
L2Z05_03970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2Z05_03990	COG3634	alkyl hydroperoxide reductase activity
L2Z05_04000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2Z05_04010	COG0450	alkyl hydroperoxide reductase
L2Z05_04015	COG1643	Atp-dependent helicase
L2Z05_04030	COG2814	Major facilitator Superfamily
L2Z05_04035	COG3135	benzoate transporter
L2Z05_04040	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_04045	COG0543	2 iron, 2 sulfur cluster binding
L2Z05_04045	COG0633	Ferredoxin
L2Z05_04050	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z05_04055	COG4638	Rieske (2fe-2S)
L2Z05_04065	COG0583	DNA-binding transcription factor activity
L2Z05_04115	COG1570	exodeoxyribonuclease VII activity
L2Z05_04150	COG1278	Cold shock
L2Z05_04185	COG2814	Major facilitator Superfamily
L2Z05_04225	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2Z05_04235	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2Z05_04240	COG1137	ATPase activity
L2Z05_04245	COG1538	Outer membrane efflux protein
L2Z05_04275	COG4122	O-methyltransferase activity
L2Z05_04285	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2Z05_04300	COG1522	sequence-specific DNA binding
L2Z05_04315	COG1560	Kdo2-lipid A biosynthetic process
L2Z05_04330	COG2814	Major facilitator Superfamily
L2Z05_04350	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z05_04385	COG0583	DNA-binding transcription factor activity
L2Z05_04390	COG1914	H( )-stimulated, divalent metal cation uptake system
L2Z05_04410	COG4770	biotin carboxylase activity
L2Z05_04415	COG0038	chloride channel
L2Z05_04420	COG2831	hemolysin activation secretion protein
L2Z05_04425	COG3210	domain, Protein
L2Z05_04450	COG1063	alcohol dehydrogenase
L2Z05_04465	COG0439	Biotin carboxylase
L2Z05_04470	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z05_04475	COG1733	regulation of RNA biosynthetic process
L2Z05_04490	COG0864	Transcriptional regulator
L2Z05_04500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z05_04505	COG1116	anion transmembrane transporter activity
L2Z05_04640	COG0590	tRNA wobble adenosine to inosine editing
L2Z05_04645	COG2807	transmembrane transport
L2Z05_04660	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2Z05_04670	COG0789	Transcriptional regulator
L2Z05_04680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z05_04700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z05_04725	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_04730	COG0531	amino acid
L2Z05_04735	COG1760	l-serine dehydratase
L2Z05_04740	COG2030	dehydratase
L2Z05_04740	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_04745	COG3396	Phenylacetate-CoA oxygenase
L2Z05_04750	COG3460	Phenylacetate-CoA oxygenase
L2Z05_04755	COG3396	Phenylacetate-CoA oxygenase
L2Z05_04760	COG2151	metal-sulfur cluster biosynthetic enzyme
L2Z05_04765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z05_04770	COG1024	Enoyl-CoA hydratase
L2Z05_04775	COG1024	Enoyl-CoA hydratase
L2Z05_04780	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z05_04785	COG0183	Belongs to the thiolase family
L2Z05_04790	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
L2Z05_04795	COG3327	negative regulation of DNA-templated transcription, initiation
L2Z05_04805	COG2050	protein possibly involved in aromatic compounds catabolism
L2Z05_04835	COG0753	catalase activity
L2Z05_04840	COG3038	cytochrome b561
L2Z05_04860	COG2267	carboxylic ester hydrolase activity
L2Z05_04865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z05_04870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z05_04885	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z05_04895	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_04900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z05_04905	COG0583	DNA-binding transcription factor activity
L2Z05_04915	COG1414	Transcriptional regulator
L2Z05_04920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z05_04930	COG1840	ABC-type Fe3 transport system, periplasmic component
L2Z05_04935	COG3842	ATPase activity
L2Z05_04950	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2Z05_04955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z05_04960	COG2814	Major facilitator Superfamily
L2Z05_04965	COG1960	acyl-CoA dehydrogenase activity
L2Z05_04970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z05_04980	COG1024	Enoyl-CoA hydratase
L2Z05_04990	COG2814	Major facilitator Superfamily
L2Z05_05000	COG0183	Belongs to the thiolase family
L2Z05_05005	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2Z05_05010	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_05015	COG1024	Enoyl-CoA hydratase
L2Z05_05020	COG1960	acyl-CoA dehydrogenase activity
L2Z05_05025	COG2814	Major facilitator Superfamily
L2Z05_05030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z05_05035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z05_05045	COG2814	Major facilitator Superfamily
L2Z05_05055	COG1960	acyl-CoA dehydrogenase activity
L2Z05_05070	COG0583	DNA-binding transcription factor activity
L2Z05_05080	COG4770	biotin carboxylase activity
L2Z05_05085	COG1024	Enoyl-CoA hydratase
L2Z05_05090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2Z05_05095	COG1960	acyl-CoA dehydrogenase activity
L2Z05_05100	COG1309	transcriptional regulator
L2Z05_05105	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z05_05125	COG0583	DNA-binding transcription factor activity
L2Z05_05175	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_05200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2Z05_05220	COG0784	Response regulator, receiver
L2Z05_05220	COG2205	protein histidine kinase activity
L2Z05_05240	COG0765	amino acid transport
L2Z05_05245	COG0765	amino acid transport
L2Z05_05250	COG1126	abc transporter atp-binding protein
L2Z05_05255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z05_05260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2Z05_05275	COG1280	lysine exporter protein (LysE YggA)
L2Z05_05280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2Z05_05285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z05_05290	COG1045	serine acetyltransferase
L2Z05_05305	COG0583	DNA-binding transcription factor activity
L2Z05_05310	COG0625	glutathione transferase activity
L2Z05_05315	COG0625	glutathione transferase activity
L2Z05_05320	COG0583	DNA-binding transcription factor activity
L2Z05_05330	COG1346	cytolysis
L2Z05_05350	COG2814	Major facilitator Superfamily
L2Z05_05360	COG0583	DNA-binding transcription factor activity
L2Z05_05370	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2Z05_05375	COG3052	prosthetic group binding
L2Z05_05395	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2Z05_05415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z05_05425	COG1294	oxidase, subunit
L2Z05_05430	COG1271	oxidase subunit
L2Z05_05450	COG0477	Major facilitator Superfamily
L2Z05_05460	COG4521	taurine ABC transporter
L2Z05_05465	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2Z05_05470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z05_05475	COG2175	clavaminate synthase activity
L2Z05_05485	COG1953	Uracil, thiamine, allantoin
L2Z05_05495	COG0583	DNA-binding transcription factor activity
L2Z05_05505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2Z05_05520	COG0640	Transcriptional regulator
L2Z05_05525	COG0798	PFAM Bile acid sodium symporter
L2Z05_05530	COG0583	DNA-binding transcription factor activity
L2Z05_05545	COG3634	alkyl hydroperoxide reductase activity
L2Z05_05585	COG0436	Aminotransferase
L2Z05_05595	COG0386	Belongs to the glutathione peroxidase family
L2Z05_05635	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z05_05660	COG0012	GTP binding
L2Z05_05665	COG2011	ABC-type metal ion transport system permease component
L2Z05_05670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z05_05680	COG1464	Belongs to the NlpA lipoprotein family
L2Z05_05710	COG0765	amino acid transport
L2Z05_05715	COG0765	amino acid transport
L2Z05_05720	COG1126	abc transporter atp-binding protein
L2Z05_05730	COG1522	sequence-specific DNA binding
L2Z05_05765	COG0583	DNA-binding transcription factor activity
L2Z05_05775	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2Z05_05785	COG0697	spore germination
L2Z05_05810	COG3121	Chaperone
L2Z05_05815	COG3539	Fimbrial protein
L2Z05_05840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
L2Z05_05840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
L2Z05_05885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2Z05_05895	COG2353	YceI-like domain
L2Z05_05905	COG3698	Phosphodiester glycosidase
L2Z05_05920	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2Z05_05925	COG0506	proline dehydrogenase activity
L2Z05_05925	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z05_05925	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2Z05_05935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z05_05940	COG2963	transposase activity
L2Z05_05950	COG4372	Transposase
L2Z05_05955	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2Z05_05975	COG1132	(ABC) transporter
L2Z05_05980	COG3122	Protein conserved in bacteria
L2Z05_05985	COG3619	membrane
L2Z05_05995	COG0640	Transcriptional regulator
L2Z05_06005	COG2850	peptidyl-arginine hydroxylation
L2Z05_06010	COG0424	maF-like protein
L2Z05_06030	COG0191	fructose-bisphosphate aldolase activity
L2Z05_06035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z05_06050	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2Z05_06060	COG1192	Involved in chromosome partitioning
L2Z05_06065	COG1475	DNA binding
L2Z05_06070	COG0811	peptide transport
L2Z05_06080	COG1132	(ABC) transporter
L2Z05_06085	COG1663	tetraacyldisaccharide 4'-kinase activity
L2Z05_06105	COG0084	hydrolase, TatD family'
L2Z05_06170	COG0776	regulation of translation
L2Z05_06200	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2Z05_06205	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2Z05_06255	COG0339	signal peptide processing
L2Z05_06265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2Z05_06300	COG0702	epimerase
L2Z05_06305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z05_06325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2Z05_06355	COG0316	Belongs to the HesB IscA family
L2Z05_06360	COG0822	iron-sulfur transferase activity
L2Z05_06385	COG0776	regulation of translation
L2Z05_06390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2Z05_06395	COG2207	Transcriptional regulator
L2Z05_06400	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z05_06405	COG1960	acyl-CoA dehydrogenase activity
L2Z05_06410	COG1960	acyl-CoA dehydrogenase activity
L2Z05_06425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2Z05_06445	COG4264	IucA IucC family
L2Z05_06450	COG4264	IucA IucC family
L2Z05_06460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2Z05_06490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2Z05_06505	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2Z05_06525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2Z05_06530	COG0730	response to heat
L2Z05_06550	COG4773	Receptor
L2Z05_06555	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z05_06570	COG1131	(ABC) transporter
L2Z05_06575	COG0842	Transport permease protein
L2Z05_06580	COG0842	Transport permease protein
L2Z05_06635	COG2226	methyltransferase
L2Z05_06660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2Z05_06695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z05_06705	COG0133	tryptophan synthase activity
L2Z05_06720	COG3706	GGDEF domain
L2Z05_06735	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z05_06740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2Z05_06745	COG0022	dehydrogenase e1 component
L2Z05_06750	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z05_06755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z05_06765	COG1063	alcohol dehydrogenase
L2Z05_06770	COG3781	membrane
L2Z05_06780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z05_06780	COG3453	Protein conserved in bacteria
L2Z05_06795	COG0730	response to heat
L2Z05_06810	COG3708	Transcriptional regulator
L2Z05_06810	COG2207	Transcriptional regulator
L2Z05_06815	COG1733	regulation of RNA biosynthetic process
L2Z05_06820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2Z05_06830	COG2188	Transcriptional regulator
L2Z05_06845	COG4521	taurine ABC transporter
L2Z05_06870	COG0477	Major facilitator Superfamily
L2Z05_06880	COG1027	Aspartate ammonia-lyase
L2Z05_06895	COG0583	DNA-binding transcription factor activity
L2Z05_06900	COG0583	DNA-binding transcription factor activity
L2Z05_06905	COG0183	Belongs to the thiolase family
L2Z05_06910	COG2031	fatty acid transporter
L2Z05_06925	COG0583	DNA-binding transcription factor activity
L2Z05_06945	COG1309	transcriptional regulator
L2Z05_06955	COG2610	gluconate transmembrane transporter activity
L2Z05_06960	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_06965	COG2207	Transcriptional regulator
L2Z05_06980	COG2963	transposase activity
L2Z05_06990	COG4372	Transposase
L2Z05_07000	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_07010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z05_07025	COG0543	2 iron, 2 sulfur cluster binding
L2Z05_07025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z05_07030	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2Z05_07035	COG4638	Rieske (2fe-2S)
L2Z05_07045	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2Z05_07050	COG4149	molybdate abc transporter
L2Z05_07055	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2Z05_07060	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_07065	COG1535	isochorismatase
L2Z05_07065	COG3433	isochorismatase activity
L2Z05_07130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2Z05_07145	COG0753	catalase activity
L2Z05_07155	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2Z05_07185	COG3539	Fimbrial protein
L2Z05_07200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2Z05_07205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z05_07210	COG0745	RESPONSE REGULATOR receiver
L2Z05_07215	COG2205	protein histidine kinase activity
L2Z05_07225	COG2207	Transcriptional regulator
L2Z05_07240	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_07245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2Z05_07250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z05_07255	COG2851	Citrate transporter
L2Z05_07260	COG1414	Transcriptional regulator
L2Z05_07265	COG2963	transposase activity
L2Z05_07275	COG4372	Transposase
L2Z05_07285	COG0583	DNA-binding transcription factor activity
L2Z05_07305	COG0477	Major facilitator Superfamily
L2Z05_07340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z05_07375	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2Z05_07425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2Z05_07445	COG1120	ATPase activity
L2Z05_07450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z05_07460	COG1064	alcohol dehydrogenase
L2Z05_07475	COG2207	Transcriptional regulator
L2Z05_07480	COG2084	Dehydrogenase
L2Z05_07490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z05_07495	COG0583	DNA-binding transcription factor activity
L2Z05_07505	COG0129	dihydroxy-acid dehydratase activity
L2Z05_07510	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_07525	COG1566	PFAM secretion protein HlyD family protein
L2Z05_07550	COG0583	DNA-binding transcription factor activity
L2Z05_07565	COG2188	Transcriptional regulator
L2Z05_07600	COG4191	Histidine kinase
L2Z05_07625	COG1473	amidohydrolase
L2Z05_07635	COG0475	glutathione-regulated potassium exporter activity
L2Z05_07635	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z05_07645	COG0583	DNA-binding transcription factor activity
L2Z05_07650	COG1335	isochorismatase
L2Z05_07660	COG1309	transcriptional regulator
L2Z05_07700	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z05_07700	COG1902	pentaerythritol trinitrate reductase activity
L2Z05_07715	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_07735	COG2186	Transcriptional regulator
L2Z05_07745	COG0583	DNA-binding transcription factor activity
L2Z05_07750	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z05_07755	COG4829	muconolactone delta-isomerase
L2Z05_07765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z05_07770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z05_07775	COG0183	Belongs to the thiolase family
L2Z05_07780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z05_07790	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_07800	COG3733	amine oxidase
L2Z05_07810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z05_07820	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_07830	COG4638	Rieske (2fe-2S)
L2Z05_07850	COG0154	amidase activity
L2Z05_07860	COG2814	Major facilitator Superfamily
L2Z05_07885	COG1960	acyl-CoA dehydrogenase activity
L2Z05_07890	COG0583	DNA-binding transcription factor activity
L2Z05_07895	COG1414	Transcriptional regulator
L2Z05_07910	COG2391	methyltransferase activity
L2Z05_07920	COG4993	Dehydrogenase
L2Z05_07925	COG3659	wide pore channel activity
L2Z05_07930	COG3420	alginic acid biosynthetic process
L2Z05_07935	COG0710	3-dehydroquinate dehydratase activity
L2Z05_07940	COG3485	protocatechuate 3,4-dioxygenase
L2Z05_07945	COG3485	protocatechuate 3,4-dioxygenase
L2Z05_07950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2Z05_07955	COG2271	Major facilitator Superfamily
L2Z05_07960	COG0596	Alpha beta hydrolase
L2Z05_07965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2Z05_07970	COG0183	Belongs to the thiolase family
L2Z05_07975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2Z05_07980	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2Z05_07990	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2Z05_07995	COG2323	membrane
L2Z05_08040	COG1902	pentaerythritol trinitrate reductase activity
L2Z05_08040	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2Z05_08065	COG0542	response to heat
L2Z05_08070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2Z05_08100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2Z05_08105	COG0569	domain protein
L2Z05_08110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2Z05_08125	COG4774	siderophore transport
L2Z05_08130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2Z05_08140	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2Z05_08155	COG1294	oxidase, subunit
L2Z05_08160	COG4890	Cyd operon protein YbgT
L2Z05_08170	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2Z05_08180	COG0552	protein localization to endoplasmic reticulum
L2Z05_08205	COG0517	IMP dehydrogenase activity
L2Z05_08205	COG0516	GMP reductase activity
L2Z05_08210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z05_08215	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2Z05_08225	COG0583	DNA-binding transcription factor activity
L2Z05_08230	COG0024	Methionine aminopeptidase
L2Z05_08260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2Z05_08260	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z05_08265	COG1105	Belongs to the carbohydrate kinase PfkB family
L2Z05_08270	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2Z05_08270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z05_08270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2Z05_08285	COG3300	MHYT domain
L2Z05_08285	COG5001	Diguanylate cyclase
L2Z05_08300	COG2963	transposase activity
L2Z05_08310	COG4372	Transposase
L2Z05_08315	COG2135	peptidase activity
L2Z05_08320	COG0659	secondary active sulfate transmembrane transporter activity
L2Z05_08340	COG1113	amino acid transport
L2Z05_08350	COG1522	sequence-specific DNA binding
L2Z05_08375	COG1011	Hydrolase
L2Z05_08380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2Z05_08390	COG2137	regulation of response to DNA damage stimulus
L2Z05_08405	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z05_08440	COG0575	Belongs to the CDS family
L2Z05_08445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2Z05_08470	COG3852	Histidine kinase
L2Z05_08475	COG2204	response regulator
L2Z05_08530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z05_08535	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2Z05_08555	COG0697	spore germination
L2Z05_08560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z05_08570	COG0303	'Molybdopterin
L2Z05_08575	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2Z05_08575	COG0315	cyclic pyranopterin monophosphate synthase activity
L2Z05_08590	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2Z05_08595	COG0243	molybdopterin cofactor binding
L2Z05_08605	COG0243	molybdopterin cofactor binding
L2Z05_08610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z05_08615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z05_08615	COG2146	nitrite reductase [NAD(P)H] activity
L2Z05_08625	COG0745	RESPONSE REGULATOR receiver
L2Z05_08630	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z05_08630	COG1116	anion transmembrane transporter activity
L2Z05_08645	COG0511	ligase activity, forming carbon-carbon bonds
L2Z05_08660	COG2814	Major facilitator Superfamily
L2Z05_08680	COG0069	glutamate synthase activity
L2Z05_08700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2Z05_08710	COG1454	alcohol dehydrogenase
L2Z05_08715	COG0824	Thioesterase
L2Z05_08730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z05_08745	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z05_08750	COG2030	dehydratase
L2Z05_08760	COG0183	Belongs to the thiolase family
L2Z05_08770	COG0583	DNA-binding transcription factor activity
L2Z05_08775	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z05_08785	COG4372	Transposase
L2Z05_08795	COG2963	transposase activity
L2Z05_08805	COG1522	sequence-specific DNA binding
L2Z05_08810	COG3135	benzoate transporter
L2Z05_08820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2Z05_08845	COG0589	response to stress
L2Z05_08850	COG0488	(ABC) transporter
L2Z05_08870	COG4773	Receptor
L2Z05_08900	COG0668	transmembrane transport
L2Z05_08910	COG1309	transcriptional regulator
L2Z05_08925	COG1605	Chorismate mutase
L2Z05_08965	COG0308	aminopeptidase N
L2Z05_08985	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
L2Z05_08995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z05_09000	COG1454	alcohol dehydrogenase
L2Z05_09020	COG0531	amino acid
L2Z05_09025	COG4303	Ethanolamine ammonia lyase large subunit
L2Z05_09030	COG4302	ethanolamine ammonia-lyase activity
L2Z05_09035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z05_09035	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z05_09040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z05_09050	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2Z05_09065	COG0697	spore germination
L2Z05_09070	COG1923	regulation of RNA biosynthetic process
L2Z05_09080	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2Z05_09085	COG0802	atpase or kinase
L2Z05_09105	COG1187	pseudouridine synthase activity
L2Z05_09120	COG0583	DNA-binding transcription factor activity
L2Z05_09135	COG2814	Major facilitator Superfamily
L2Z05_09140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2Z05_09165	COG0729	surface antigen
L2Z05_09185	COG0174	glutamine synthetase
L2Z05_09190	COG0745	RESPONSE REGULATOR receiver
L2Z05_09195	COG2205	protein histidine kinase activity
L2Z05_09205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2Z05_09210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2Z05_09220	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L2Z05_09235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z05_09240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z05_09245	COG1960	acyl-CoA dehydrogenase activity
L2Z05_09275	COG0583	DNA-binding transcription factor activity
L2Z05_09290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z05_09300	COG3658	cytochrome
L2Z05_09305	COG1215	transferase activity, transferring glycosyl groups
L2Z05_09310	COG0726	polysaccharide deacetylase
L2Z05_09310	COG1649	PFAM Uncharacterised BCR, COG1649
L2Z05_09335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2Z05_09340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2Z05_09350	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2Z05_09375	COG0305	Participates in initiation and elongation during chromosome replication
L2Z05_09380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2Z05_09390	COG1305	Transglutaminase-like
L2Z05_09400	COG2308	Evidence 4 Homologs of previously reported genes of
L2Z05_09430	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2Z05_09435	COG0138	bifunctional purine biosynthesis protein purh
L2Z05_09440	COG0151	Belongs to the GarS family
L2Z05_09445	COG1464	Belongs to the NlpA lipoprotein family
L2Z05_09450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2Z05_09455	COG2011	ABC-type metal ion transport system permease component
L2Z05_09460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z05_09470	COG1301	dicarboxylic acid transport
L2Z05_09505	COG1794	racemase activity, acting on amino acids and derivatives
L2Z05_09515	COG3008	intermembrane lipid transfer
L2Z05_09515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2Z05_09520	COG2995	paraquat-inducible protein a
L2Z05_09550	COG1051	belongs to the nudix hydrolase family
L2Z05_09555	COG0477	Major facilitator Superfamily
L2Z05_09600	COG2186	Transcriptional regulator
L2Z05_09610	COG0786	glutamate:sodium symporter activity
L2Z05_09615	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2Z05_09640	COG3111	PFAM Bacterial OB fold (BOF) protein
L2Z05_09725	COG3210	domain, Protein
L2Z05_09725	COG3210	domain, Protein
L2Z05_09730	COG2831	hemolysin activation secretion protein
L2Z05_09755	COG0515	serine threonine protein kinase
L2Z05_09755	COG2815	serine threonine protein kinase
L2Z05_09785	COG1610	YqeY-like protein
L2Z05_09790	COG4783	chaperone-mediated protein folding
L2Z05_09815	COG1286	toxin biosynthetic process
L2Z05_09845	COG0778	Nitroreductase
L2Z05_09855	COG0513	Belongs to the DEAD box helicase family
L2Z05_09880	COG2363	Small membrane protein
L2Z05_09910	COG1234	tRNA 3'-trailer cleavage
L2Z05_09915	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2Z05_09925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2Z05_09935	COG2819	hydrolase of the alpha beta superfamily
L2Z05_09940	COG1960	acyl-CoA dehydrogenase activity
L2Z05_09945	COG1301	dicarboxylic acid transport
L2Z05_09950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2Z05_09955	COG3139	Protein of unknown function (DUF1315)
L2Z05_09960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2Z05_09965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2Z05_09975	COG0494	nUDIX hydrolase
L2Z05_09985	COG0642	Histidine kinase
L2Z05_10000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2Z05_10010	COG1720	tRNA m6t6A37 methyltransferase activity
L2Z05_10020	COG0384	phenazine biosynthesis protein PhzF
L2Z05_10025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z05_10030	COG0826	peptidase U32
L2Z05_10035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z05_10045	COG4598	ABC transporter
L2Z05_10050	COG4160	amino acid transport
L2Z05_10055	COG4215	(ABC) transporter
L2Z05_10070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z05_10315	COG5410	chromosome segregation
L2Z05_10335	COG4372	Transposase
L2Z05_10345	COG2963	transposase activity
L2Z05_10505	COG0582	viral genome integration into host DNA
L2Z05_10510	COG1131	(ABC) transporter
L2Z05_10515	COG0842	Transport permease protein
L2Z05_10530	COG0772	Belongs to the SEDS family
L2Z05_10535	COG2951	lytic endotransglycosylase activity
L2Z05_10560	COG2207	Transcriptional regulator
L2Z05_10575	COG0052	Belongs to the universal ribosomal protein uS2 family
L2Z05_10580	COG0024	Methionine aminopeptidase
L2Z05_10590	COG2223	nitrite transmembrane transporter activity
L2Z05_10600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z05_10605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2Z05_10610	COG1960	acyl-CoA dehydrogenase activity
L2Z05_10625	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2Z05_10630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2Z05_10635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z05_10655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z05_10660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2Z05_10665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2Z05_10700	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2Z05_10710	COG0174	glutamine synthetase
L2Z05_10725	COG0582	viral genome integration into host DNA
L2Z05_10800	COG0739	heme binding
L2Z05_10800	COG0741	lytic transglycosylase activity
L2Z05_10800	COG1196	nuclear chromosome segregation
L2Z05_11100	COG0512	Glutamine amidotransferase of anthranilate synthase
L2Z05_11105	COG0308	aminopeptidase N
L2Z05_11135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2Z05_11145	COG0302	gtp cyclohydrolase
L2Z05_11170	COG3739	integral membrane protein
L2Z05_11195	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2Z05_11200	COG1132	(ABC) transporter
L2Z05_11205	COG1132	(ABC) transporter
L2Z05_11215	COG1535	isochorismatase
L2Z05_11215	COG3433	isochorismatase activity
L2Z05_11220	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2Z05_11225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z05_11235	COG4774	siderophore transport
L2Z05_11240	COG4607	ABC-type enterochelin transport system periplasmic component
L2Z05_11245	COG4604	ABC transporter, ATP-binding protein
L2Z05_11250	COG4605	iron ion homeostasis
L2Z05_11255	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2Z05_11260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2Z05_11275	COG2964	Protein conserved in bacteria
L2Z05_11285	COG1741	Belongs to the pirin family
L2Z05_11300	COG1309	transcriptional regulator
L2Z05_11310	COG4372	Transposase
L2Z05_11320	COG2963	transposase activity
L2Z05_11330	COG4948	Mandelate Racemase Muconate Lactonizing
L2Z05_11335	COG2814	Major facilitator Superfamily
L2Z05_11370	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
L2Z05_11370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2Z05_11375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2Z05_11385	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_11400	COG0477	Major facilitator Superfamily
L2Z05_11405	COG0006	proline dipeptidase activity
L2Z05_11410	COG1902	pentaerythritol trinitrate reductase activity
L2Z05_11415	COG0583	DNA-binding transcription factor activity
L2Z05_11425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2Z05_11435	COG0596	Alpha beta hydrolase
L2Z05_11450	COG0583	DNA-binding transcription factor activity
L2Z05_11455	COG1335	isochorismatase
L2Z05_11500	COG2879	small protein
L2Z05_11505	COG1966	Carbon starvation protein
L2Z05_11525	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L2Z05_11550	COG1067	ATP-dependent peptidase activity
L2Z05_11555	COG0583	DNA-binding transcription factor activity
L2Z05_11580	COG1686	Belongs to the peptidase S11 family
L2Z05_11585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2Z05_11620	COG0616	signal peptide processing
L2Z05_11625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2Z05_11635	COG0573	inorganic phosphate transmembrane transporter activity
L2Z05_11640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2Z05_11645	COG1113	amino acid transport
L2Z05_11650	COG3961	Belongs to the TPP enzyme family
L2Z05_11655	COG1522	sequence-specific DNA binding
L2Z05_11665	COG0076	glutamate decarboxylase activity
L2Z05_11670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z05_11685	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z05_11695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z05_11730	COG0352	thiamine-phosphate diphosphorylase activity
L2Z05_11755	COG0612	Peptidase, M16
L2Z05_11765	COG1823	symporter activity
L2Z05_11770	COG0583	DNA-binding transcription factor activity
L2Z05_11775	COG0477	Major facilitator Superfamily
L2Z05_11800	COG1187	pseudouridine synthase activity
L2Z05_11815	COG1686	Belongs to the peptidase S11 family
L2Z05_11820	COG1252	NADH dehydrogenase
L2Z05_11830	COG0415	Belongs to the DNA photolyase family
L2Z05_11845	COG1215	transferase activity, transferring glycosyl groups
L2Z05_11875	COG2070	2-Nitropropane dioxygenase
L2Z05_11930	COG0556	nucleotide-excision repair
L2Z05_11950	COG0436	Aminotransferase
L2Z05_11965	COG0443	Heat shock 70 kDa protein
L2Z05_11995	COG4221	oxidoreductase activity
L2Z05_12005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2Z05_12010	COG1381	Involved in DNA repair and RecF pathway recombination
L2Z05_12020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2Z05_12035	COG0681	Belongs to the peptidase S26 family
L2Z05_12050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2Z05_12070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2Z05_12075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2Z05_12080	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2Z05_12090	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2Z05_12095	COG4208	sulfate ABC transporter
L2Z05_12100	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2Z05_12105	COG0583	DNA-binding transcription factor activity
L2Z05_12110	COG4625	pathogenesis
L2Z05_12125	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2Z05_12140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2Z05_12150	COG1051	belongs to the nudix hydrolase family
L2Z05_12150	COG1056	cytidyltransferase-related domain
L2Z05_12155	COG1024	Enoyl-CoA hydratase
L2Z05_12165	COG2814	Major facilitator Superfamily
L2Z05_12170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2Z05_12170	COG0047	phosphoribosylformylglycinamidine synthase activity
L2Z05_12190	COG1473	amidohydrolase
L2Z05_12195	COG0824	Thioesterase
L2Z05_12215	COG0823	Involved in the tonB-independent uptake of proteins
L2Z05_12235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z05_12255	COG2963	transposase activity
L2Z05_12265	COG4372	Transposase
L2Z05_12285	COG0628	permease
L2Z05_12295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2Z05_12300	COG0596	Alpha beta hydrolase
L2Z05_12305	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2Z05_12305	COG0616	signal peptide processing
L2Z05_12315	COG2333	competence protein COMEC
L2Z05_12315	COG0658	competence protein
L2Z05_12320	COG1136	(ABC) transporter
L2Z05_12325	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2Z05_12360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z05_12380	COG0463	Glycosyl transferase, family 2
L2Z05_12410	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2Z05_12415	COG1280	lysine exporter protein (LysE YggA)
L2Z05_12425	COG0019	diaminopimelate decarboxylase activity
L2Z05_12435	COG1113	amino acid transport
L2Z05_12450	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2Z05_12460	COG3339	Conserved Protein
L2Z05_12465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2Z05_12470	COG0243	molybdopterin cofactor binding
L2Z05_12475	COG1929	Belongs to the glycerate kinase type-1 family
L2Z05_12490	COG0778	Nitroreductase
L2Z05_12510	COG3811	Belongs to the UPF0386 family
L2Z05_12535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2Z05_12555	COG0741	lytic transglycosylase activity
L2Z05_12575	COG0584	glycerophosphoryl diester phosphodiesterase
L2Z05_12580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z05_12605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z05_12610	COG1597	lipid kinase activity
L2Z05_12625	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2Z05_12630	COG0477	Major facilitator Superfamily
L2Z05_12680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2Z05_12685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2Z05_12710	COG0505	Belongs to the CarA family
L2Z05_12730	COG0589	response to stress
L2Z05_12745	COG2843	Capsule synthesis protein
L2Z05_12765	COG2321	neutral zinc metallopeptidase
L2Z05_12770	COG2354	Protein conserved in bacteria
L2Z05_12790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2Z05_12815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2Z05_12820	COG1053	succinate dehydrogenase
L2Z05_12825	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2Z05_12830	COG2009	succinate dehydrogenase
L2Z05_12870	COG2921	Belongs to the UPF0250 family
L2Z05_12875	COG0321	lipoyl(octanoyl) transferase activity
L2Z05_12890	COG0531	amino acid
L2Z05_12900	COG1733	regulation of RNA biosynthetic process
L2Z05_12905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2Z05_12910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2Z05_12910	COG1648	precorrin-2 dehydrogenase activity
L2Z05_12925	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2Z05_12955	COG0671	phosphoesterase, PA-phosphatase related
L2Z05_12960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z05_12970	COG1538	Outer membrane efflux protein
L2Z05_12975	COG0393	Putative heavy-metal-binding
L2Z05_12980	COG0393	Putative heavy-metal-binding
L2Z05_12990	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_13000	COG0525	valine-tRNA ligase activity
L2Z05_13005	COG2226	methyltransferase
L2Z05_13020	COG0583	DNA-binding transcription factor activity
L2Z05_13025	COG0004	ammonium transporteR
L2Z05_13035	COG0642	Histidine kinase
L2Z05_13040	COG0745	RESPONSE REGULATOR receiver
L2Z05_13045	COG2194	sulfuric ester hydrolase activity
L2Z05_13055	COG2963	transposase activity
L2Z05_13065	COG4372	Transposase
L2Z05_13070	COG4372	Transposase
L2Z05_13080	COG2963	transposase activity
L2Z05_13095	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2Z05_13110	COG2315	Protein conserved in bacteria
L2Z05_13115	COG0142	geranyltranstransferase activity
L2Z05_13120	COG2828	Protein conserved in bacteria
L2Z05_13125	COG1113	amino acid transport
L2Z05_13140	COG4372	Transposase
L2Z05_13150	COG2963	transposase activity
L2Z05_13180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2Z05_13190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2Z05_13195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2Z05_13200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2Z05_13260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2Z05_13270	COG1846	Transcriptional regulator
L2Z05_13275	COG1764	response to oxidative stress
L2Z05_13315	COG0037	tRNA processing
L2Z05_13325	COG0248	Ppx GppA phosphatase
L2Z05_13355	COG0072	phenylalanine-tRNA ligase activity
L2Z05_13400	COG1238	metal cluster binding
L2Z05_13405	COG0625	glutathione transferase activity
L2Z05_13420	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z05_13425	COG3028	Belongs to the UPF0307 family
L2Z05_13430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2Z05_13450	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2Z05_13455	COG0617	tRNA 3'-terminal CCA addition
L2Z05_13460	COG1555	photosystem II stabilization
L2Z05_13465	COG3956	TIGRFAM MazG family protein
L2Z05_13475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z05_13495	COG0784	Response regulator, receiver
L2Z05_13495	COG2205	protein histidine kinase activity
L2Z05_13495	COG5002	protein histidine kinase activity
L2Z05_13500	COG1024	Enoyl-CoA hydratase
L2Z05_13505	COG2084	Dehydrogenase
L2Z05_13510	COG3622	Belongs to the hyi family
L2Z05_13540	COG0697	spore germination
L2Z05_13550	COG2814	Major facilitator Superfamily
L2Z05_13555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2Z05_13565	COG0583	DNA-binding transcription factor activity
L2Z05_13575	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2Z05_13585	COG0084	hydrolase, TatD family'
L2Z05_13600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2Z05_13630	COG0440	acetolactate synthase activity
L2Z05_13635	COG0028	Belongs to the TPP enzyme family
L2Z05_13660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z05_13665	COG0577	efflux transmembrane transporter activity
L2Z05_13665	COG1136	(ABC) transporter
L2Z05_13670	COG1538	Outer membrane efflux protein
L2Z05_13685	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2Z05_13690	COG1162	GTPase activity
L2Z05_13700	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2Z05_13740	COG1426	Protein conserved in bacteria
L2Z05_13775	COG0793	Belongs to the peptidase S41A family
L2Z05_13790	COG2267	carboxylic ester hydrolase activity
L2Z05_13800	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_13805	COG3265	gluconokinase activity
L2Z05_13815	COG0800	Aldolase
L2Z05_13825	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2Z05_13830	COG0280	phosphate acetyltransferase
L2Z05_13830	COG0857	belongs to the CobB CobQ family
L2Z05_13835	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z05_13835	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2Z05_13855	COG0740	serine-type endopeptidase activity
L2Z05_13865	COG4774	siderophore transport
L2Z05_13875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2Z05_13885	COG2813	Specifically methylates the guanine in position
L2Z05_13885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2Z05_13985	COG0788	formyltetrahydrofolate deformylase activity
L2Z05_14010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z05_14010	COG4651	solute:proton antiporter activity
L2Z05_14030	COG0724	RNA recognition motif
L2Z05_14035	COG0210	DNA helicase
L2Z05_14060	COG1733	regulation of RNA biosynthetic process
L2Z05_14070	COG2900	Belongs to the SlyX family
L2Z05_14075	COG0488	(ABC) transporter
L2Z05_14080	COG1280	lysine exporter protein (LysE YggA)
L2Z05_14085	COG1560	Kdo2-lipid A biosynthetic process
L2Z05_14095	COG1301	dicarboxylic acid transport
L2Z05_14150	COG0473	3-isopropylmalate dehydrogenase activity
L2Z05_14220	COG0583	DNA-binding transcription factor activity
L2Z05_14230	COG0625	glutathione transferase activity
L2Z05_14235	COG2378	regulation of single-species biofilm formation
L2Z05_14240	COG0546	phosphoglycolate phosphatase activity
L2Z05_14250	COG1530	ribonuclease E activity
L2Z05_14255	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z05_14270	COG0583	DNA-binding transcription factor activity
L2Z05_14275	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_14280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2Z05_14290	COG0534	Mate efflux family protein
L2Z05_14305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2Z05_14315	COG4372	Transposase
L2Z05_14325	COG2963	transposase activity
L2Z05_14335	COG2963	transposase activity
L2Z05_14355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2Z05_14360	COG0583	DNA-binding transcription factor activity
L2Z05_14390	COG2030	dehydratase
L2Z05_14395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z05_14410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2Z05_14445	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2Z05_14445	COG0493	'glutamate synthase
L2Z05_14455	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2Z05_14460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2Z05_14475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z05_14485	COG0644	oxidoreductase
L2Z05_14485	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2Z05_14495	COG0425	Belongs to the sulfur carrier protein TusA family
L2Z05_14500	COG4535	Mg2 and Co2 transporter CorC
L2Z05_14510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2Z05_14530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2Z05_14535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2Z05_14535	COG0475	glutathione-regulated potassium exporter activity
L2Z05_14550	COG0484	heat shock protein binding
L2Z05_14555	COG0789	Transcriptional regulator
L2Z05_14560	COG0598	Magnesium transport protein CorA
L2Z05_14575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2Z05_14580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z05_14585	COG1074	ATP-dependent DNA helicase activity
L2Z05_14590	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2Z05_14610	COG2226	methyltransferase
L2Z05_14625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z05_14630	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2Z05_14645	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2Z05_14645	COG2111	Na H antiporter
L2Z05_14650	COG1006	Multisubunit Na H antiporter MnhC subunit
L2Z05_14655	COG0651	ATP synthesis coupled electron transport
L2Z05_14660	COG1863	multisubunit Na H antiporter MnhE subunit
L2Z05_14665	COG2212	antiporter activity
L2Z05_14670	COG1320	monovalent cation:proton antiporter activity
L2Z05_14685	COG0195	Participates in both transcription termination and antitermination
L2Z05_14740	COG0237	dephospho-CoA kinase activity
L2Z05_14750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2Z05_14765	COG0497	DNA recombination
L2Z05_14775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2Z05_14805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2Z05_14805	COG2169	Transcriptional regulator
L2Z05_14810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2Z05_14860	COG0789	Transcriptional regulator
L2Z05_14870	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2Z05_14885	COG0326	Molecular chaperone. Has ATPase activity
L2Z05_14900	COG2056	Na+-H+ antiporter family
L2Z05_15000	COG0546	phosphoglycolate phosphatase activity
L2Z05_15005	COG1716	ATPase activity
L2Z05_15050	COG0181	hydroxymethylbilane synthase activity
L2Z05_15060	COG3275	phosphorelay sensor kinase activity
L2Z05_15080	COG1538	Outer membrane efflux protein
L2Z05_15085	COG0697	spore germination
L2Z05_15110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2Z05_15115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2Z05_15120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2Z05_15125	COG0772	Belongs to the SEDS family
L2Z05_15150	COG4974	Belongs to the 'phage' integrase family
L2Z05_15155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z05_15165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2Z05_15175	COG2197	response regulator
L2Z05_15190	COG0793	Belongs to the peptidase S41A family
L2Z05_15195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2Z05_15200	COG0795	lipopolysaccharide-transporting ATPase activity
L2Z05_15240	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z05_15240	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2Z05_15250	COG0004	ammonium transporteR
L2Z05_15255	COG0347	Belongs to the P(II) protein family
L2Z05_15340	COG2132	Multicopper oxidase
L2Z05_15355	COG2205	protein histidine kinase activity
L2Z05_15360	COG2217	Heavy metal translocating P-type atpase
L2Z05_15380	COG2963	transposase activity
L2Z05_15390	COG4372	Transposase
L2Z05_15420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z05_15425	COG0235	Class ii aldolase
L2Z05_15430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z05_15450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2Z05_15465	COG0318	PFAM AMP-dependent synthetase and ligase
L2Z05_15475	COG0477	Major facilitator Superfamily
L2Z05_15480	COG2860	membrane
L2Z05_15485	COG3012	SEC-C Motif Domain Protein
L2Z05_15490	COG1253	flavin adenine dinucleotide binding
L2Z05_15500	COG0477	Major facilitator Superfamily
L2Z05_15510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2Z05_15550	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2Z05_15560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2Z05_15630	COG0758	DNA mediated transformation
L2Z05_15640	COG0697	spore germination
L2Z05_15645	COG1309	transcriptional regulator
L2Z05_15660	COG0386	Belongs to the glutathione peroxidase family
L2Z05_15730	COG1121	(ABC) transporter
L2Z05_15735	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2Z05_15740	COG1280	lysine exporter protein (LysE YggA)
L2Z05_15745	COG2837	iron assimilation
L2Z05_15755	COG0281	malic enzyme
L2Z05_15800	COG0519	Catalyzes the synthesis of GMP from XMP
L2Z05_15800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2Z05_15805	COG4399	Belongs to the UPF0754 family
L2Z05_15810	COG2259	Doxx family
L2Z05_15815	COG0586	Pfam SNARE associated Golgi protein
L2Z05_15830	COG1192	Involved in chromosome partitioning
L2Z05_15840	COG0271	Belongs to the BolA IbaG family
L2Z05_15880	COG3321	synthase
L2Z05_15880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2Z05_15880	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2Z05_15880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2Z05_15885	COG1960	acyl-CoA dehydrogenase activity
L2Z05_15895	COG2197	response regulator
L2Z05_15905	COG3916	Acyl-homoserine-lactone synthase
L2Z05_15910	COG0477	Major facilitator Superfamily
L2Z05_15915	COG1024	Enoyl-CoA hydratase
L2Z05_15920	COG1024	Enoyl-CoA hydratase
L2Z05_15925	COG1960	acyl-CoA dehydrogenase activity
L2Z05_15930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z05_15950	COG1113	amino acid transport
L2Z05_15955	COG1113	amino acid transport
L2Z05_15960	COG0251	oxidation-reduction process
L2Z05_16000	COG0564	pseudouridine synthase activity
L2Z05_16070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2Z05_16085	COG1802	Transcriptional regulator
L2Z05_16095	COG1448	Aminotransferase
L2Z05_16100	COG0277	FAD linked oxidase domain protein
L2Z05_16110	COG2186	Transcriptional regulator
L2Z05_16120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z05_16125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2Z05_16140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2Z05_16145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2Z05_16150	COG1216	Glycosyl transferase, family 2
L2Z05_16170	COG0438	transferase activity, transferring glycosyl groups
L2Z05_16200	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2Z05_16230	COG0728	peptidoglycan biosynthetic process
L2Z05_16235	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2Z05_16295	COG0546	phosphoglycolate phosphatase activity
L2Z05_16300	COG1028	Short-chain dehydrogenase reductase Sdr
L2Z05_16320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z05_16325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2Z05_16330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2Z05_16335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2Z05_16340	COG1116	anion transmembrane transporter activity
L2Z05_16345	COG1309	transcriptional regulator
L2Z05_16350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2Z05_16360	COG0196	riboflavin kinase activity
L2Z05_16365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2Z05_16375	COG1047	Peptidyl-prolyl cis-trans
L2Z05_16415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2Z05_16420	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2Z05_16425	COG0596	Alpha beta hydrolase
L2Z05_16450	COG0488	(ABC) transporter
L2Z05_16455	COG0586	Pfam SNARE associated Golgi protein
L2Z05_16465	COG0187	DNA topoisomerase II activity
L2Z05_16475	COG0592	DNA-directed DNA polymerase activity
L2Z05_16500	COG0706	membrane insertase activity
L2Z05_16515	COG1230	cation diffusion facilitator family transporter
L2Z05_16520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2Z05_16535	COG0402	S-adenosylhomocysteine deaminase activity
L2Z05_16545	COG0754	glutathionylspermidine amidase activity
L2Z05_16555	COG0861	Integral membrane protein TerC family
L2Z05_16560	COG0671	phosphoesterase, PA-phosphatase related
L2Z05_16570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2Z05_16585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2Z05_16590	COG2951	lytic endotransglycosylase activity
L2Z05_16620	COG0583	DNA-binding transcription factor activity
L2Z05_16640	COG0657	acetylesterase activity
L2Z05_16645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2Z05_16685	COG0733	neurotransmitter:sodium symporter activity
L2Z05_16720	COG0583	DNA-binding transcription factor activity
L2Z05_16725	COG2233	PERMEase
L2Z05_16740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2Z05_16775	COG2814	Major facilitator Superfamily
L2Z05_16780	COG0656	L-ascorbic acid biosynthetic process
L2Z05_16785	COG0583	DNA-binding transcription factor activity
L2Z05_16800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2Z05_16805	COG1064	alcohol dehydrogenase
L2Z05_16810	COG2818	Glycosylase
L2Z05_16825	COG1194	a g-specific adenine glycosylase
L2Z05_16845	COG2983	Belongs to the UPF0260 family
L2Z05_16850	COG2133	pyrroloquinoline quinone binding
L2Z05_16855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2Z05_16860	COG2116	formate transmembrane transporter activity
L2Z05_16880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2Z05_16885	COG1335	isochorismatase
L2Z05_16890	COG0385	Bile acid
L2Z05_16900	COG1683	Conserved Protein
L2Z05_16920	COG0625	glutathione transferase activity
L2Z05_16930	COG1113	amino acid transport
L2Z05_16940	COG0523	cobalamin synthesis protein
L2Z05_16950	COG2188	Transcriptional regulator
L2Z05_16980	COG1192	Involved in chromosome partitioning
L2Z05_17075	COG3173	Aminoglycoside phosphotransferase
L2Z05_17080	COG0488	(ABC) transporter
L2Z05_17160	COG0789	Transcriptional regulator
L2Z05_17190	COG3550	peptidyl-serine autophosphorylation
L2Z05_17265	COG0616	signal peptide processing
L2Z05_17355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2Z05_17390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2Z05_17395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2Z05_17405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2Z05_17410	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2Z05_17495	COG0534	Mate efflux family protein
L2Z05_17500	COG0436	Aminotransferase
L2Z05_17505	COG2733	membrane
L2Z05_17520	COG2918	glutathione biosynthetic process
L2Z05_17535	COG3179	chitinase
L2Z05_17550	COG3150	esterase
L2Z05_17560	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2Z05_17570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2Z05_17580	COG2233	PERMEase
L2Z05_17585	COG2351	hydroxyisourate hydrolase activity
L2Z05_17620	COG3706	GGDEF domain
L2Z05_17635	COG1393	Belongs to the ArsC family
L2Z05_17640	COG0708	Exodeoxyribonuclease III
L2Z05_17665	COG0189	ligase activity
L2Z05_17685	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2Z05_17695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2Z05_17710	COG4942	peptidase
L2Z05_17720	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2Z05_17730	COG2119	membrane
L2Z05_17735	COG4774	siderophore transport
L2Z05_17740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2Z05_17740	COG0426	domain, Protein
L2Z05_17765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2Z05_17790	COG1902	pentaerythritol trinitrate reductase activity
L2Z05_17795	COG1519	Transferase
L2Z05_17800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2Z05_17805	COG0668	transmembrane transport
L2Z05_17815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2Z05_17820	COG1335	isochorismatase
L2Z05_17825	COG1522	sequence-specific DNA binding
L2Z05_17850	COG2205	protein histidine kinase activity
L2Z05_17850	COG2198	Histidine kinase
L2Z05_17850	COG0784	Response regulator, receiver
L2Z05_17855	COG3162	membrane
L2Z05_17860	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2Z05_17870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2Z05_17890	COG1309	transcriptional regulator
L2Z05_17910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2Z05_17910	COG0352	thiamine-phosphate diphosphorylase activity
L2Z05_17910	COG0351	phosphomethylpyrimidine kinase
L2Z05_17920	COG2814	Major facilitator Superfamily
L2Z05_17935	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2Z05_17945	COG1113	amino acid transport
L2Z05_17955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2Z05_17960	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_17970	COG1335	isochorismatase
L2Z05_18000	COG2814	Major facilitator Superfamily
L2Z05_18005	COG0583	DNA-binding transcription factor activity
L2Z05_18025	COG0667	Aldo Keto reductase
L2Z05_18055	COG1733	regulation of RNA biosynthetic process
L2Z05_18060	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z05_18120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2Z05_18165	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2Z05_18195	COG0427	acetyl-CoA hydrolase
L2Z05_18220	COG0659	secondary active sulfate transmembrane transporter activity
L2Z05_18225	COG4221	oxidoreductase activity
L2Z05_18235	COG0488	(ABC) transporter
L2Z05_18300	COG0833	amino acid
L2Z05_18345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2Z05_18350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2Z05_18365	COG2226	methyltransferase
L2Z05_18415	COG0070	glutamate synthase
L2Z05_18415	COG0069	glutamate synthase activity
L2Z05_18415	COG0067	glutamate synthase
L2Z05_18420	COG0493	'glutamate synthase
L2Z05_18430	COG1704	LemA family
L2Z05_18435	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2Z05_18455	COG3307	-O-antigen
L2Z05_18475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2Z05_18490	COG0194	GDP metabolic process
L2Z05_18540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2Z05_18560	COG5380	lipid catabolic process
L2Z05_18565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2Z05_18590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2Z05_18595	COG0277	FAD linked oxidase domain protein
L2Z05_18610	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2Z05_18615	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2Z05_18630	COG1289	transmembrane transporter activity
L2Z05_18640	COG0628	permease
L2Z05_18645	COG1192	Involved in chromosome partitioning
L2Z05_18675	COG0833	amino acid
L2Z05_18680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2Z05_18685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2Z05_18695	COG1012	belongs to the aldehyde dehydrogenase family
L2Z05_18735	COG0583	DNA-binding transcription factor activity
L2Z05_18785	COG0517	IMP dehydrogenase activity
L2Z05_18790	COG1983	PspC domain protein
L2Z05_18800	COG1960	acyl-CoA dehydrogenase activity
L2Z05_18815	COG0408	coproporphyrinogen oxidase activity
L2Z05_18835	COG0513	Belongs to the DEAD box helicase family
L2Z05_18845	COG1127	ABC transporter
L2Z05_18850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2Z05_18860	COG2854	intermembrane phospholipid transfer
L2Z05_18870	COG0598	Magnesium transport protein CorA
L2Z05_18880	COG0494	nUDIX hydrolase
L2Z05_18885	COG1040	competence protein
L2Z05_18890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2Z05_18910	COG1946	Acyl-CoA thioesterase
L2Z05_18915	COG1301	dicarboxylic acid transport
L2Z05_18930	COG1959	2 iron, 2 sulfur cluster binding
L2Z05_18935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2Z05_18935	COG1017	nitric oxide dioxygenase activity
L2Z05_18945	COG0433	COG0433 Predicted ATPase
L2Z05_18950	COG0626	cystathionine gamma-synthase activity
L2Z05_19105	COG1960	acyl-CoA dehydrogenase activity
L2Z05_19110	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2Z05_19140	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2Z05_19145	COG0339	signal peptide processing
L2Z05_19150	COG0557	exoribonuclease II activity
L2Z05_19200	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2Z05_19205	COG2169	Transcriptional regulator
L2Z05_19210	COG0697	spore germination
L2Z05_19215	COG1295	ribonuclease BN
L2Z05_19250	COG1702	phosphate starvation-inducible protein PhoH
L2Z05_19260	COG0741	lytic transglycosylase activity
L2Z05_19260	COG0739	heme binding
L2Z05_19260	COG1196	nuclear chromosome segregation
L2Z05_19290	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2Z05_19295	COG1183	phosphatidylcholine synthase activity
L2Z05_19340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2Z05_19390	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system