locus-tag	class	description
L2M54_00010	COG0592	DNA-directed DNA polymerase activity
L2M54_00020	COG0187	DNA topoisomerase II activity
L2M54_00030	COG0586	Pfam SNARE associated Golgi protein
L2M54_00035	COG0488	(ABC) transporter
L2M54_00060	COG0596	Alpha beta hydrolase
L2M54_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
L2M54_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2M54_00110	COG1047	Peptidyl-prolyl cis-trans
L2M54_00120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2M54_00125	COG0196	riboflavin kinase activity
L2M54_00135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2M54_00140	COG1309	transcriptional regulator
L2M54_00145	COG1116	anion transmembrane transporter activity
L2M54_00150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2M54_00155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2M54_00160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2M54_00165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2M54_00185	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_00190	COG0546	phosphoglycolate phosphatase activity
L2M54_00245	COG3023	N-Acetylmuramoyl-L-alanine amidase
L2M54_00250	COG0728	peptidoglycan biosynthetic process
L2M54_00280	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
L2M54_00290	COG1215	transferase activity, transferring glycosyl groups
L2M54_00295	COG0438	transferase activity, transferring glycosyl groups
L2M54_00305	COG0438	transferase activity, transferring glycosyl groups
L2M54_00315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2M54_00320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2M54_00335	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2M54_00345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2M54_00355	COG2186	Transcriptional regulator
L2M54_00365	COG0277	FAD linked oxidase domain protein
L2M54_00370	COG1448	Aminotransferase
L2M54_00380	COG1802	Transcriptional regulator
L2M54_00395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2M54_00425	COG2801	Transposase and inactivated derivatives
L2M54_00530	COG0251	oxidation-reduction process
L2M54_00535	COG1113	amino acid transport
L2M54_00540	COG1113	amino acid transport
L2M54_00560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2M54_00565	COG1960	acyl-CoA dehydrogenase activity
L2M54_00570	COG1024	Enoyl-CoA hydratase
L2M54_00575	COG1024	Enoyl-CoA hydratase
L2M54_00580	COG0477	Major facilitator Superfamily
L2M54_00585	COG3916	Acyl-homoserine-lactone synthase
L2M54_00595	COG2197	response regulator
L2M54_00605	COG1960	acyl-CoA dehydrogenase activity
L2M54_00610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2M54_00610	COG3321	synthase
L2M54_00610	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
L2M54_00610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
L2M54_00650	COG0271	Belongs to the BolA IbaG family
L2M54_00660	COG1192	Involved in chromosome partitioning
L2M54_00675	COG0586	Pfam SNARE associated Golgi protein
L2M54_00680	COG2259	Doxx family
L2M54_00685	COG4399	Belongs to the UPF0754 family
L2M54_00690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2M54_00690	COG0519	Catalyzes the synthesis of GMP from XMP
L2M54_00735	COG0281	malic enzyme
L2M54_00740	COG2837	iron assimilation
L2M54_00745	COG1280	lysine exporter protein (LysE YggA)
L2M54_00750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2M54_00755	COG1121	(ABC) transporter
L2M54_00820	COG0386	Belongs to the glutathione peroxidase family
L2M54_00835	COG1309	transcriptional regulator
L2M54_00840	COG0697	spore germination
L2M54_00850	COG0758	DNA mediated transformation
L2M54_00920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2M54_00930	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2M54_00970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2M54_00990	COG1253	flavin adenine dinucleotide binding
L2M54_00995	COG3012	SEC-C Motif Domain Protein
L2M54_01000	COG2860	membrane
L2M54_01005	COG0477	Major facilitator Superfamily
L2M54_01015	COG0318	PFAM AMP-dependent synthetase and ligase
L2M54_01030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
L2M54_01050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2M54_01065	COG0606	chelatase, subunit chli
L2M54_01075	COG0347	Belongs to the P(II) protein family
L2M54_01080	COG0004	ammonium transporteR
L2M54_01090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2M54_01090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2M54_01130	COG0795	lipopolysaccharide-transporting ATPase activity
L2M54_01135	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2M54_01155	COG2197	response regulator
L2M54_01165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2M54_01175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2M54_01180	COG4974	Belongs to the 'phage' integrase family
L2M54_01205	COG0772	Belongs to the SEDS family
L2M54_01210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2M54_01215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2M54_01220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2M54_01245	COG0697	spore germination
L2M54_01250	COG1538	Outer membrane efflux protein
L2M54_01270	COG3275	phosphorelay sensor kinase activity
L2M54_01280	COG0181	hydroxymethylbilane synthase activity
L2M54_01325	COG1716	ATPase activity
L2M54_01330	COG0546	phosphoglycolate phosphatase activity
L2M54_01425	COG0596	Alpha beta hydrolase
L2M54_01430	COG2056	Na+-H+ antiporter family
L2M54_01445	COG0326	Molecular chaperone. Has ATPase activity
L2M54_01460	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2M54_01530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2M54_01565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2M54_01575	COG0497	DNA recombination
L2M54_01590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2M54_01600	COG0237	dephospho-CoA kinase activity
L2M54_01605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
L2M54_01655	COG0195	Participates in both transcription termination and antitermination
L2M54_01670	COG1320	monovalent cation:proton antiporter activity
L2M54_01675	COG2212	antiporter activity
L2M54_01680	COG1863	multisubunit Na H antiporter MnhE subunit
L2M54_01685	COG0651	ATP synthesis coupled electron transport
L2M54_01690	COG1006	Multisubunit Na H antiporter MnhC subunit
L2M54_01695	COG2111	Na H antiporter
L2M54_01695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2M54_01710	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2M54_01740	COG2226	methyltransferase
L2M54_01760	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
L2M54_01765	COG1074	ATP-dependent DNA helicase activity
L2M54_01770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2M54_01775	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2M54_01790	COG0598	Magnesium transport protein CorA
L2M54_01795	COG0789	Transcriptional regulator
L2M54_01800	COG0484	heat shock protein binding
L2M54_01815	COG0475	glutathione-regulated potassium exporter activity
L2M54_01815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2M54_01820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2M54_01850	COG4535	Mg2 and Co2 transporter CorC
L2M54_01855	COG0425	Belongs to the sulfur carrier protein TusA family
L2M54_01865	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
L2M54_01865	COG0644	oxidoreductase
L2M54_01875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2M54_01890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2M54_01895	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
L2M54_01905	COG0493	'glutamate synthase
L2M54_01905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2M54_01930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
L2M54_01945	COG0534	Mate efflux family protein
L2M54_01955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2M54_01960	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_01965	COG0583	DNA-binding transcription factor activity
L2M54_01980	COG0318	PFAM AMP-dependent synthetase and ligase
L2M54_01985	COG1530	ribonuclease E activity
L2M54_01995	COG0546	phosphoglycolate phosphatase activity
L2M54_02000	COG2378	regulation of single-species biofilm formation
L2M54_02005	COG0625	glutathione transferase activity
L2M54_02015	COG0583	DNA-binding transcription factor activity
L2M54_02080	COG0473	3-isopropylmalate dehydrogenase activity
L2M54_02135	COG1301	dicarboxylic acid transport
L2M54_02145	COG1560	Kdo2-lipid A biosynthetic process
L2M54_02150	COG1280	lysine exporter protein (LysE YggA)
L2M54_02160	COG0488	(ABC) transporter
L2M54_02165	COG2900	Belongs to the SlyX family
L2M54_02175	COG1733	regulation of RNA biosynthetic process
L2M54_02200	COG0210	DNA helicase
L2M54_02205	COG0724	RNA recognition motif
L2M54_02225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2M54_02225	COG4651	solute:proton antiporter activity
L2M54_02250	COG0788	formyltetrahydrofolate deformylase activity
L2M54_02350	COG2813	Specifically methylates the guanine in position
L2M54_02350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2M54_02360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2M54_02380	COG0740	serine-type endopeptidase activity
L2M54_02400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
L2M54_02400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
L2M54_02405	COG0857	belongs to the CobB CobQ family
L2M54_02405	COG0280	phosphate acetyltransferase
L2M54_02410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2M54_02420	COG0800	Aldolase
L2M54_02430	COG3265	gluconokinase activity
L2M54_02435	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_02445	COG2267	carboxylic ester hydrolase activity
L2M54_02460	COG0793	Belongs to the peptidase S41A family
L2M54_02495	COG1426	Protein conserved in bacteria
L2M54_02515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2M54_02535	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2M54_02545	COG1162	GTPase activity
L2M54_02550	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
L2M54_02565	COG1538	Outer membrane efflux protein
L2M54_02570	COG1136	(ABC) transporter
L2M54_02570	COG0577	efflux transmembrane transporter activity
L2M54_02600	COG0028	Belongs to the TPP enzyme family
L2M54_02605	COG0440	acetolactate synthase activity
L2M54_02775	COG0084	hydrolase, TatD family'
L2M54_02790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
L2M54_02805	COG0084	hydrolase, TatD family'
L2M54_02820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2M54_02830	COG0583	DNA-binding transcription factor activity
L2M54_02840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2M54_02855	COG1358	cellular component organization or biogenesis
L2M54_02900	COG2814	Major facilitator Superfamily
L2M54_02910	COG0697	spore germination
L2M54_02940	COG3622	Belongs to the hyi family
L2M54_02945	COG2084	Dehydrogenase
L2M54_02950	COG1024	Enoyl-CoA hydratase
L2M54_02955	COG0784	Response regulator, receiver
L2M54_02955	COG2205	protein histidine kinase activity
L2M54_02955	COG5002	protein histidine kinase activity
L2M54_02975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2M54_02985	COG3956	TIGRFAM MazG family protein
L2M54_02990	COG1555	photosystem II stabilization
L2M54_02995	COG0617	tRNA 3'-terminal CCA addition
L2M54_03020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2M54_03025	COG3028	Belongs to the UPF0307 family
L2M54_03030	COG0318	PFAM AMP-dependent synthetase and ligase
L2M54_03045	COG0625	glutathione transferase activity
L2M54_03050	COG1238	metal cluster binding
L2M54_03095	COG0072	phenylalanine-tRNA ligase activity
L2M54_03125	COG0248	Ppx GppA phosphatase
L2M54_03135	COG0037	tRNA processing
L2M54_03175	COG1764	response to oxidative stress
L2M54_03180	COG1846	Transcriptional regulator
L2M54_03190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2M54_03250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2M54_03255	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2M54_03260	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2M54_03320	COG1214	PFAM Peptidase M22, glycoprotease
L2M54_03335	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
L2M54_03345	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2M54_03350	COG0561	phosphatase activity
L2M54_03360	COG2132	Multicopper oxidase
L2M54_03365	COG3667	copper resistance
L2M54_03380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2M54_03385	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2M54_03390	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2M54_03420	COG1063	alcohol dehydrogenase
L2M54_03425	COG0583	DNA-binding transcription factor activity
L2M54_03430	COG1960	acyl-CoA dehydrogenase activity
L2M54_03435	COG2814	Major facilitator Superfamily
L2M54_03440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2M54_03445	COG1309	transcriptional regulator
L2M54_03460	COG1053	succinate dehydrogenase
L2M54_03465	COG0583	DNA-binding transcription factor activity
L2M54_03480	COG0583	DNA-binding transcription factor activity
L2M54_03510	COG0583	DNA-binding transcription factor activity
L2M54_03525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2M54_03585	COG0384	phenazine biosynthesis protein PhzF
L2M54_03600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2M54_03620	COG0745	RESPONSE REGULATOR receiver
L2M54_03660	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
L2M54_03690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2M54_03695	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
L2M54_03715	COG0583	DNA-binding transcription factor activity
L2M54_03735	COG0668	transmembrane transport
L2M54_03745	COG2081	HI0933 family
L2M54_03750	COG2515	1-aminocyclopropane-1-carboxylate deaminase
L2M54_03780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2M54_03780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2M54_03790	COG0489	protein tyrosine kinase activity
L2M54_03840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2M54_03850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2M54_03865	COG0730	response to heat
L2M54_03875	COG1196	nuclear chromosome segregation
L2M54_03895	COG2223	nitrite transmembrane transporter activity
L2M54_03900	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
L2M54_03905	COG1877	trehalose-phosphatase activity
L2M54_03910	COG2226	methyltransferase
L2M54_03910	COG0596	Alpha beta hydrolase
L2M54_03910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2M54_03925	COG4106	trans-aconitate 2-methyltransferase activity
L2M54_03940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2M54_03945	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2M54_03950	COG0009	L-threonylcarbamoyladenylate synthase
L2M54_03955	COG3101	peptidyl-lysine hydroxylation
L2M54_03960	COG1399	metal-binding, possibly nucleic acid-binding protein
L2M54_03985	COG1652	LysM domain
L2M54_03990	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2M54_03990	COG0351	phosphomethylpyrimidine kinase
L2M54_03990	COG0352	thiamine-phosphate diphosphorylase activity
L2M54_04000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2M54_04030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2M54_04060	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
L2M54_04075	COG0358	DNA primase activity
L2M54_04085	COG0564	pseudouridine synthase activity
L2M54_04145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2M54_04200	COG0305	Participates in initiation and elongation during chromosome replication
L2M54_04495	COG0582	viral genome integration into host DNA
L2M54_04505	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2M54_04525	COG0583	DNA-binding transcription factor activity
L2M54_04530	COG0473	3-isopropylmalate dehydrogenase activity
L2M54_04540	COG0657	acetylesterase activity
L2M54_04550	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_04570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2M54_04570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2M54_04585	COG1981	membrane
L2M54_04630	COG0456	acetyltransferase
L2M54_04640	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
L2M54_04645	COG0492	ferredoxin-NADP+ reductase activity
L2M54_04650	COG1674	ftsk spoiiie
L2M54_04650	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2M54_04655	COG1280	lysine exporter protein (LysE YggA)
L2M54_04670	COG2894	cell division
L2M54_04685	COG0204	Acyl-transferase
L2M54_04690	COG2885	chlorophyll binding
L2M54_04695	COG0210	DNA helicase
L2M54_04705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2M54_04720	COG0121	glutamine amidotransferase
L2M54_04740	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2M54_04745	COG0735	belongs to the Fur family
L2M54_04770	COG0420	3'-5' exonuclease activity
L2M54_04790	COG1090	epimerase
L2M54_04805	COG2050	protein possibly involved in aromatic compounds catabolism
L2M54_04815	COG2814	Major facilitator Superfamily
L2M54_04820	COG0405	Gamma-glutamyltransferase
L2M54_04860	COG1396	sequence-specific DNA binding
L2M54_04880	COG0477	Major facilitator Superfamily
L2M54_04885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2M54_04910	COG0531	amino acid
L2M54_04915	COG2040	homocysteine
L2M54_04940	COG1309	transcriptional regulator
L2M54_04945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2M54_04950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2M54_04960	COG1607	acyl-coa hydrolase
L2M54_04970	COG0523	cobalamin synthesis protein
L2M54_04980	COG4681	YaeQ
L2M54_04990	COG1649	PFAM Uncharacterised BCR, COG1649
L2M54_04990	COG0726	polysaccharide deacetylase
L2M54_04995	COG1215	transferase activity, transferring glycosyl groups
L2M54_05005	COG1024	Enoyl-CoA hydratase
L2M54_05020	COG1414	Transcriptional regulator
L2M54_05040	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_05050	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2M54_05055	COG2271	Major facilitator Superfamily
L2M54_05065	COG2267	carboxylic ester hydrolase activity
L2M54_05070	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_05085	COG0028	Belongs to the TPP enzyme family
L2M54_05095	COG0477	Major facilitator Superfamily
L2M54_05100	COG0242	peptide deformylase activity
L2M54_05105	COG2066	Belongs to the glutaminase family
L2M54_05110	COG2207	Transcriptional regulator
L2M54_05115	COG2223	nitrite transmembrane transporter activity
L2M54_05130	COG0583	DNA-binding transcription factor activity
L2M54_05135	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_05140	COG2271	Major facilitator Superfamily
L2M54_05145	COG3959	Transketolase, thiamine diphosphate binding domain
L2M54_05150	COG3958	Transketolase
L2M54_05195	COG0306	phosphate transporter
L2M54_05215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2M54_05235	COG4771	TonB-dependent receptor
L2M54_05260	COG4181	ATPase activity
L2M54_05265	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
L2M54_05295	COG0583	DNA-binding transcription factor activity
L2M54_05305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2M54_05310	COG1773	rubredoxin
L2M54_05360	COG2851	Citrate transporter
L2M54_05365	COG1253	flavin adenine dinucleotide binding
L2M54_05405	COG0804	urea catabolic process
L2M54_05415	COG0830	nickel cation binding
L2M54_05430	COG0742	ribosomal rna small subunit methyltransferase
L2M54_05435	COG0768	penicillin binding
L2M54_05460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2M54_05465	COG2878	Part of a membrane complex involved in electron transport
L2M54_05470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2M54_05480	COG3384	dioxygenase
L2M54_05515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2M54_05595	COG0305	Participates in initiation and elongation during chromosome replication
L2M54_05675	COG4695	Portal protein
L2M54_06110	COG0006	proline dipeptidase activity
L2M54_06115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2M54_06120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2M54_06140	COG1279	arginine transmembrane transporter activity
L2M54_06145	COG0583	DNA-binding transcription factor activity
L2M54_06185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2M54_06190	COG0741	lytic transglycosylase activity
L2M54_06190	COG0741	lytic transglycosylase activity
L2M54_06190	COG1388	LysM domain
L2M54_06190	COG1388	LysM domain
L2M54_06200	COG4174	ABC transporter (Permease)
L2M54_06205	COG4239	(ABC) transporter, permease
L2M54_06210	COG4172	Belongs to the ABC transporter superfamily
L2M54_06230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2M54_06240	COG2203	Gaf domain
L2M54_06240	COG4251	negative regulation of phosphorylation
L2M54_06240	COG5001	Diguanylate cyclase
L2M54_06240	COG3706	GGDEF domain
L2M54_06250	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2M54_06250	COG1902	pentaerythritol trinitrate reductase activity
L2M54_06260	COG0457	Tetratricopeptide repeat
L2M54_06270	COG0251	oxidation-reduction process
L2M54_06280	COG0583	DNA-binding transcription factor activity
L2M54_06295	COG2801	Transposase and inactivated derivatives
L2M54_06375	COG3209	COG3209 Rhs family protein
L2M54_06440	COG1113	amino acid transport
L2M54_06450	COG0531	amino acid
L2M54_06470	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_06490	COG1113	amino acid transport
L2M54_06505	COG0697	spore germination
L2M54_06510	COG2721	sulfolactate sulfo-lyase activity
L2M54_06515	COG2271	Major facilitator Superfamily
L2M54_06520	COG4948	Mandelate Racemase Muconate Lactonizing
L2M54_06530	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_06535	COG2186	Transcriptional regulator
L2M54_06560	COG1960	acyl-CoA dehydrogenase activity
L2M54_06570	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_06575	COG1024	Enoyl-CoA hydratase
L2M54_06580	COG2814	Major facilitator Superfamily
L2M54_06595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2M54_06610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2M54_06650	COG2207	Transcriptional regulator
L2M54_06655	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
L2M54_06660	COG2072	flavoprotein involved in K transport
L2M54_06665	COG0300	oxidoreductase activity
L2M54_06675	COG1309	transcriptional regulator
L2M54_06680	COG1741	Belongs to the pirin family
L2M54_06705	COG2252	PERMEase
L2M54_06710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
L2M54_06720	COG3038	cytochrome b561
L2M54_06730	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2M54_06740	COG0527	aspartate kinase activity
L2M54_06760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2M54_06775	COG0667	Aldo Keto reductase
L2M54_06790	COG1765	OsmC-like protein
L2M54_06805	COG0542	response to heat
L2M54_06840	COG2885	chlorophyll binding
L2M54_06850	COG0625	glutathione transferase activity
L2M54_06855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2M54_06875	COG3634	alkyl hydroperoxide reductase activity
L2M54_06885	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
L2M54_06900	COG1643	Atp-dependent helicase
L2M54_06915	COG2814	Major facilitator Superfamily
L2M54_06920	COG3135	benzoate transporter
L2M54_06925	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_06930	COG0543	2 iron, 2 sulfur cluster binding
L2M54_06930	COG0633	Ferredoxin
L2M54_06940	COG4638	Rieske (2fe-2S)
L2M54_06950	COG0583	DNA-binding transcription factor activity
L2M54_07030	COG1280	lysine exporter protein (LysE YggA)
L2M54_07035	COG1278	Cold shock
L2M54_07115	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2M54_07115	COG0517	IMP dehydrogenase activity
L2M54_07120	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
L2M54_07130	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
L2M54_07135	COG1137	ATPase activity
L2M54_07140	COG1538	Outer membrane efflux protein
L2M54_07170	COG4122	O-methyltransferase activity
L2M54_07180	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
L2M54_07195	COG1522	sequence-specific DNA binding
L2M54_07210	COG1560	Kdo2-lipid A biosynthetic process
L2M54_07245	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2M54_07375	COG0583	DNA-binding transcription factor activity
L2M54_07380	COG1914	H( )-stimulated, divalent metal cation uptake system
L2M54_07400	COG4770	biotin carboxylase activity
L2M54_07405	COG0038	chloride channel
L2M54_07410	COG2831	hemolysin activation secretion protein
L2M54_07415	COG3210	domain, Protein
L2M54_07435	COG2801	Transposase and inactivated derivatives
L2M54_07455	COG3328	transposase activity
L2M54_07475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2M54_07480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2M54_07485	COG2271	Major facilitator Superfamily
L2M54_07490	COG0753	catalase activity
L2M54_07495	COG3038	cytochrome b561
L2M54_07515	COG2267	carboxylic ester hydrolase activity
L2M54_07520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2M54_07525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2M54_07530	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_07540	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2M54_07550	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_07555	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2M54_07560	COG0583	DNA-binding transcription factor activity
L2M54_07570	COG1414	Transcriptional regulator
L2M54_07575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2M54_07585	COG1840	ABC-type Fe3 transport system, periplasmic component
L2M54_07590	COG3842	ATPase activity
L2M54_07605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2M54_07610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2M54_07615	COG2814	Major facilitator Superfamily
L2M54_07620	COG1960	acyl-CoA dehydrogenase activity
L2M54_07635	COG1024	Enoyl-CoA hydratase
L2M54_07645	COG2814	Major facilitator Superfamily
L2M54_07655	COG0183	Belongs to the thiolase family
L2M54_07660	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2M54_07665	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_07670	COG1024	Enoyl-CoA hydratase
L2M54_07675	COG1960	acyl-CoA dehydrogenase activity
L2M54_07680	COG2814	Major facilitator Superfamily
L2M54_07685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2M54_07690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2M54_07700	COG2814	Major facilitator Superfamily
L2M54_07710	COG1960	acyl-CoA dehydrogenase activity
L2M54_07725	COG0583	DNA-binding transcription factor activity
L2M54_07735	COG4770	biotin carboxylase activity
L2M54_07740	COG1024	Enoyl-CoA hydratase
L2M54_07745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2M54_07750	COG1960	acyl-CoA dehydrogenase activity
L2M54_07755	COG1309	transcriptional regulator
L2M54_07760	COG0318	PFAM AMP-dependent synthetase and ligase
L2M54_07780	COG0583	DNA-binding transcription factor activity
L2M54_07835	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_07860	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2M54_07880	COG0784	Response regulator, receiver
L2M54_07880	COG2205	protein histidine kinase activity
L2M54_07900	COG0765	amino acid transport
L2M54_07905	COG0765	amino acid transport
L2M54_07915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2M54_07920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2M54_07935	COG1280	lysine exporter protein (LysE YggA)
L2M54_07940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2M54_07965	COG0583	DNA-binding transcription factor activity
L2M54_07970	COG0625	glutathione transferase activity
L2M54_07975	COG0625	glutathione transferase activity
L2M54_07980	COG0583	DNA-binding transcription factor activity
L2M54_07990	COG1346	cytolysis
L2M54_08010	COG2814	Major facilitator Superfamily
L2M54_08020	COG0583	DNA-binding transcription factor activity
L2M54_08030	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
L2M54_08035	COG3052	prosthetic group binding
L2M54_08055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2M54_08075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2M54_08085	COG1294	oxidase, subunit
L2M54_08090	COG1271	oxidase subunit
L2M54_08110	COG0477	Major facilitator Superfamily
L2M54_08120	COG4521	taurine ABC transporter
L2M54_08125	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
L2M54_08130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2M54_08135	COG2175	clavaminate synthase activity
L2M54_08145	COG1953	Uracil, thiamine, allantoin
L2M54_08155	COG0583	DNA-binding transcription factor activity
L2M54_08165	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2M54_08180	COG0640	Transcriptional regulator
L2M54_08185	COG0798	PFAM Bile acid sodium symporter
L2M54_08190	COG0583	DNA-binding transcription factor activity
L2M54_08205	COG3634	alkyl hydroperoxide reductase activity
L2M54_08245	COG0436	Aminotransferase
L2M54_08255	COG0386	Belongs to the glutathione peroxidase family
L2M54_08295	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2M54_08320	COG0012	GTP binding
L2M54_08325	COG2011	ABC-type metal ion transport system permease component
L2M54_08330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2M54_08340	COG1464	Belongs to the NlpA lipoprotein family
L2M54_08370	COG0765	amino acid transport
L2M54_08375	COG0765	amino acid transport
L2M54_08380	COG1126	abc transporter atp-binding protein
L2M54_08390	COG1522	sequence-specific DNA binding
L2M54_08405	COG1309	transcriptional regulator
L2M54_08425	COG0583	DNA-binding transcription factor activity
L2M54_08435	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
L2M54_08445	COG0697	spore germination
L2M54_08475	COG3121	Chaperone
L2M54_08480	COG3539	Fimbrial protein
L2M54_08550	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2M54_08560	COG2353	YceI-like domain
L2M54_08570	COG3698	Phosphodiester glycosidase
L2M54_08585	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2M54_08590	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2M54_08590	COG0506	proline dehydrogenase activity
L2M54_08590	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
L2M54_08600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2M54_08605	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2M54_08625	COG1132	(ABC) transporter
L2M54_08630	COG3122	Protein conserved in bacteria
L2M54_08635	COG3619	membrane
L2M54_08645	COG0640	Transcriptional regulator
L2M54_08655	COG2850	peptidyl-arginine hydroxylation
L2M54_08660	COG0424	maF-like protein
L2M54_08680	COG0191	fructose-bisphosphate aldolase activity
L2M54_08685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2M54_08700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2M54_08710	COG1192	Involved in chromosome partitioning
L2M54_08715	COG1475	DNA binding
L2M54_08720	COG0811	peptide transport
L2M54_08730	COG1132	(ABC) transporter
L2M54_08735	COG1663	tetraacyldisaccharide 4'-kinase activity
L2M54_08755	COG0084	hydrolase, TatD family'
L2M54_08820	COG0776	regulation of translation
L2M54_08850	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
L2M54_08855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
L2M54_08895	COG0339	signal peptide processing
L2M54_08905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2M54_08940	COG0702	epimerase
L2M54_08945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2M54_08965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2M54_08995	COG0316	Belongs to the HesB IscA family
L2M54_09000	COG0822	iron-sulfur transferase activity
L2M54_09025	COG0776	regulation of translation
L2M54_09030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2M54_09035	COG2207	Transcriptional regulator
L2M54_09040	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2M54_09045	COG1960	acyl-CoA dehydrogenase activity
L2M54_09050	COG1960	acyl-CoA dehydrogenase activity
L2M54_09065	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2M54_09085	COG4264	IucA IucC family
L2M54_09090	COG4264	IucA IucC family
L2M54_09100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2M54_09130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2M54_09145	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
L2M54_09150	COG0406	alpha-ribazole phosphatase activity
L2M54_09165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
L2M54_09170	COG0730	response to heat
L2M54_09190	COG4773	Receptor
L2M54_09195	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2M54_09225	COG1131	(ABC) transporter
L2M54_09230	COG0842	Transport permease protein
L2M54_09235	COG0842	Transport permease protein
L2M54_09290	COG2226	methyltransferase
L2M54_09315	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2M54_09355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2M54_09365	COG0133	tryptophan synthase activity
L2M54_09380	COG3706	GGDEF domain
L2M54_09395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2M54_09400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2M54_09405	COG0022	dehydrogenase e1 component
L2M54_09410	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2M54_09415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2M54_09425	COG1063	alcohol dehydrogenase
L2M54_09430	COG3781	membrane
L2M54_09440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2M54_09440	COG3453	Protein conserved in bacteria
L2M54_09455	COG0730	response to heat
L2M54_09470	COG2207	Transcriptional regulator
L2M54_09470	COG3708	Transcriptional regulator
L2M54_09475	COG1733	regulation of RNA biosynthetic process
L2M54_09480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2M54_09490	COG2188	Transcriptional regulator
L2M54_09505	COG4521	taurine ABC transporter
L2M54_09510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2M54_09530	COG0477	Major facilitator Superfamily
L2M54_09540	COG1027	Aspartate ammonia-lyase
L2M54_09555	COG0583	DNA-binding transcription factor activity
L2M54_09560	COG0583	DNA-binding transcription factor activity
L2M54_09565	COG0183	Belongs to the thiolase family
L2M54_09570	COG2031	fatty acid transporter
L2M54_09585	COG0583	DNA-binding transcription factor activity
L2M54_09595	COG2610	gluconate transmembrane transporter activity
L2M54_09600	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_09605	COG2207	Transcriptional regulator
L2M54_09620	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_09630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2M54_09645	COG0543	2 iron, 2 sulfur cluster binding
L2M54_09645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2M54_09650	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
L2M54_09655	COG4638	Rieske (2fe-2S)
L2M54_09665	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2M54_09670	COG4149	molybdate abc transporter
L2M54_09675	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
L2M54_09680	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_09685	COG1535	isochorismatase
L2M54_09685	COG3433	isochorismatase activity
L2M54_09745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2M54_09760	COG0753	catalase activity
L2M54_09770	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
L2M54_09795	COG3539	Fimbrial protein
L2M54_09855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2M54_09865	COG2072	flavoprotein involved in K transport
L2M54_09875	COG1538	Outer membrane efflux protein
L2M54_09880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2M54_09885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2M54_09890	COG0745	RESPONSE REGULATOR receiver
L2M54_09895	COG2205	protein histidine kinase activity
L2M54_09925	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_09935	COG1073	alpha beta
L2M54_09965	COG2801	Transposase and inactivated derivatives
L2M54_09990	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
L2M54_10060	COG1120	ATPase activity
L2M54_10065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2M54_10080	COG1064	alcohol dehydrogenase
L2M54_10085	COG2207	Transcriptional regulator
L2M54_10090	COG2084	Dehydrogenase
L2M54_10100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2M54_10105	COG0583	DNA-binding transcription factor activity
L2M54_10115	COG0129	dihydroxy-acid dehydratase activity
L2M54_10120	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_10150	COG0583	DNA-binding transcription factor activity
L2M54_10165	COG2188	Transcriptional regulator
L2M54_10245	COG1473	amidohydrolase
L2M54_10255	COG0475	glutathione-regulated potassium exporter activity
L2M54_10255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2M54_10265	COG0583	DNA-binding transcription factor activity
L2M54_10270	COG1335	isochorismatase
L2M54_10280	COG1309	transcriptional regulator
L2M54_10310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2M54_10320	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2M54_10320	COG1902	pentaerythritol trinitrate reductase activity
L2M54_10335	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_10355	COG2186	Transcriptional regulator
L2M54_10375	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_10385	COG3733	amine oxidase
L2M54_10395	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2M54_10405	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_10415	COG4638	Rieske (2fe-2S)
L2M54_10435	COG0154	amidase activity
L2M54_10445	COG2814	Major facilitator Superfamily
L2M54_10470	COG1960	acyl-CoA dehydrogenase activity
L2M54_10475	COG0583	DNA-binding transcription factor activity
L2M54_10480	COG1414	Transcriptional regulator
L2M54_10495	COG2391	methyltransferase activity
L2M54_10505	COG4993	Dehydrogenase
L2M54_10510	COG3659	wide pore channel activity
L2M54_10515	COG3420	alginic acid biosynthetic process
L2M54_10520	COG0710	3-dehydroquinate dehydratase activity
L2M54_10525	COG3485	protocatechuate 3,4-dioxygenase
L2M54_10530	COG3485	protocatechuate 3,4-dioxygenase
L2M54_10535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2M54_10540	COG2271	Major facilitator Superfamily
L2M54_10545	COG0596	Alpha beta hydrolase
L2M54_10550	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2M54_10555	COG0183	Belongs to the thiolase family
L2M54_10560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2M54_10565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2M54_10575	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2M54_10580	COG2323	membrane
L2M54_10625	COG1902	pentaerythritol trinitrate reductase activity
L2M54_10625	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2M54_10650	COG0542	response to heat
L2M54_10655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
L2M54_10685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2M54_10690	COG0569	domain protein
L2M54_10695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2M54_10710	COG4774	siderophore transport
L2M54_10715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2M54_10725	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2M54_10740	COG1294	oxidase, subunit
L2M54_10745	COG4890	Cyd operon protein YbgT
L2M54_10760	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
L2M54_10770	COG0552	protein localization to endoplasmic reticulum
L2M54_10795	COG0516	GMP reductase activity
L2M54_10795	COG0517	IMP dehydrogenase activity
L2M54_10800	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2M54_10805	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
L2M54_10815	COG0583	DNA-binding transcription factor activity
L2M54_10820	COG0024	Methionine aminopeptidase
L2M54_10850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2M54_10850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2M54_10855	COG1105	Belongs to the carbohydrate kinase PfkB family
L2M54_10860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2M54_10860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2M54_10860	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
L2M54_10875	COG3300	MHYT domain
L2M54_10875	COG5001	Diguanylate cyclase
L2M54_10890	COG2135	peptidase activity
L2M54_10895	COG0659	secondary active sulfate transmembrane transporter activity
L2M54_10915	COG1113	amino acid transport
L2M54_10925	COG1522	sequence-specific DNA binding
L2M54_10950	COG1011	Hydrolase
L2M54_10955	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2M54_10965	COG2137	regulation of response to DNA damage stimulus
L2M54_10980	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
L2M54_11000	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
L2M54_11015	COG0575	Belongs to the CDS family
L2M54_11020	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2M54_11040	COG3852	Histidine kinase
L2M54_11045	COG2204	response regulator
L2M54_11100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2M54_11105	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
L2M54_11125	COG0697	spore germination
L2M54_11155	COG0303	'Molybdopterin
L2M54_11160	COG0315	cyclic pyranopterin monophosphate synthase activity
L2M54_11160	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2M54_11175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2M54_11180	COG0243	molybdopterin cofactor binding
L2M54_11190	COG0243	molybdopterin cofactor binding
L2M54_11195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2M54_11200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2M54_11200	COG2146	nitrite reductase [NAD(P)H] activity
L2M54_11210	COG0745	RESPONSE REGULATOR receiver
L2M54_11215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2M54_11215	COG1116	anion transmembrane transporter activity
L2M54_11235	COG0511	ligase activity, forming carbon-carbon bonds
L2M54_11250	COG2814	Major facilitator Superfamily
L2M54_11255	COG2194	sulfuric ester hydrolase activity
L2M54_11275	COG5410	chromosome segregation
L2M54_11440	COG0069	glutamate synthase activity
L2M54_11460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2M54_11470	COG1454	alcohol dehydrogenase
L2M54_11475	COG0824	Thioesterase
L2M54_11485	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2M54_11510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2M54_11515	COG2030	dehydratase
L2M54_11525	COG0183	Belongs to the thiolase family
L2M54_11540	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2M54_11550	COG1522	sequence-specific DNA binding
L2M54_11555	COG3135	benzoate transporter
L2M54_11565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2M54_11590	COG0589	response to stress
L2M54_11595	COG0488	(ABC) transporter
L2M54_11615	COG4773	Receptor
L2M54_11645	COG0668	transmembrane transport
L2M54_11655	COG1309	transcriptional regulator
L2M54_11665	COG2801	Transposase and inactivated derivatives
L2M54_11680	COG1605	Chorismate mutase
L2M54_11690	COG4221	oxidoreductase activity
L2M54_11720	COG0308	aminopeptidase N
L2M54_11745	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2M54_11750	COG1454	alcohol dehydrogenase
L2M54_11770	COG0531	amino acid
L2M54_11775	COG4303	Ethanolamine ammonia lyase large subunit
L2M54_11780	COG4302	ethanolamine ammonia-lyase activity
L2M54_11785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2M54_11785	COG0519	Catalyzes the synthesis of GMP from XMP
L2M54_11790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2M54_11815	COG0697	spore germination
L2M54_11820	COG1923	regulation of RNA biosynthetic process
L2M54_11830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2M54_11835	COG0802	atpase or kinase
L2M54_11855	COG1187	pseudouridine synthase activity
L2M54_11870	COG0583	DNA-binding transcription factor activity
L2M54_11885	COG2814	Major facilitator Superfamily
L2M54_11890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2M54_11915	COG0729	surface antigen
L2M54_11935	COG0174	glutamine synthetase
L2M54_11940	COG0745	RESPONSE REGULATOR receiver
L2M54_11945	COG2205	protein histidine kinase activity
L2M54_11955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
L2M54_11960	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
L2M54_11985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2M54_11990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2M54_11995	COG1960	acyl-CoA dehydrogenase activity
L2M54_12025	COG0583	DNA-binding transcription factor activity
L2M54_12040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2M54_12050	COG3658	cytochrome
L2M54_12055	COG1215	transferase activity, transferring glycosyl groups
L2M54_12060	COG0726	polysaccharide deacetylase
L2M54_12060	COG1649	PFAM Uncharacterised BCR, COG1649
L2M54_12085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2M54_12090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2M54_12100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2M54_12125	COG0305	Participates in initiation and elongation during chromosome replication
L2M54_12130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2M54_12140	COG1305	Transglutaminase-like
L2M54_12150	COG2308	Evidence 4 Homologs of previously reported genes of
L2M54_12180	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
L2M54_12185	COG0138	bifunctional purine biosynthesis protein purh
L2M54_12190	COG0151	Belongs to the GarS family
L2M54_12195	COG1464	Belongs to the NlpA lipoprotein family
L2M54_12200	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2M54_12205	COG2011	ABC-type metal ion transport system permease component
L2M54_12210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2M54_12220	COG1301	dicarboxylic acid transport
L2M54_12250	COG1794	racemase activity, acting on amino acids and derivatives
L2M54_12270	COG0745	RESPONSE REGULATOR receiver
L2M54_12275	COG0642	Histidine kinase
L2M54_12280	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2M54_12290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
L2M54_12330	COG2351	hydroxyisourate hydrolase activity
L2M54_12340	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
L2M54_12340	COG3008	intermembrane lipid transfer
L2M54_12345	COG2995	paraquat-inducible protein a
L2M54_12370	COG2801	Transposase and inactivated derivatives
L2M54_12385	COG1051	belongs to the nudix hydrolase family
L2M54_12390	COG0477	Major facilitator Superfamily
L2M54_12440	COG2186	Transcriptional regulator
L2M54_12450	COG0786	glutamate:sodium symporter activity
L2M54_12455	COG3243	poly(R)-hydroxyalkanoic acid synthase
L2M54_12480	COG3111	PFAM Bacterial OB fold (BOF) protein
L2M54_12605	COG1610	YqeY-like protein
L2M54_12610	COG4783	chaperone-mediated protein folding
L2M54_12635	COG1286	toxin biosynthetic process
L2M54_12665	COG0778	Nitroreductase
L2M54_12675	COG0513	Belongs to the DEAD box helicase family
L2M54_12700	COG2363	Small membrane protein
L2M54_12730	COG1234	tRNA 3'-trailer cleavage
L2M54_12760	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2M54_12775	COG1960	acyl-CoA dehydrogenase activity
L2M54_12780	COG1301	dicarboxylic acid transport
L2M54_12785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2M54_12790	COG3139	Protein of unknown function (DUF1315)
L2M54_12795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2M54_12800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2M54_12810	COG0494	nUDIX hydrolase
L2M54_12820	COG0642	Histidine kinase
L2M54_12835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2M54_12845	COG1720	tRNA m6t6A37 methyltransferase activity
L2M54_12865	COG0826	peptidase U32
L2M54_12870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
L2M54_12880	COG4598	ABC transporter
L2M54_12885	COG4160	amino acid transport
L2M54_12890	COG4215	(ABC) transporter
L2M54_12905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2M54_12950	COG1131	(ABC) transporter
L2M54_12955	COG0842	Transport permease protein
L2M54_12970	COG0772	Belongs to the SEDS family
L2M54_12975	COG2951	lytic endotransglycosylase activity
L2M54_13000	COG2207	Transcriptional regulator
L2M54_13015	COG0052	Belongs to the universal ribosomal protein uS2 family
L2M54_13020	COG0024	Methionine aminopeptidase
L2M54_13030	COG2223	nitrite transmembrane transporter activity
L2M54_13040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2M54_13045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2M54_13050	COG1960	acyl-CoA dehydrogenase activity
L2M54_13065	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
L2M54_13070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2M54_13075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2M54_13095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2M54_13100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2M54_13105	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2M54_13140	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
L2M54_13150	COG0174	glutamine synthetase
L2M54_13165	COG0512	Glutamine amidotransferase of anthranilate synthase
L2M54_13170	COG0308	aminopeptidase N
L2M54_13200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
L2M54_13210	COG0302	gtp cyclohydrolase
L2M54_13230	COG3739	integral membrane protein
L2M54_13245	COG1169	isochorismate synthase
L2M54_13250	COG2977	Belongs to the P-Pant transferase superfamily
L2M54_13255	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2M54_13260	COG1132	(ABC) transporter
L2M54_13265	COG1132	(ABC) transporter
L2M54_13280	COG3433	isochorismatase activity
L2M54_13280	COG1535	isochorismatase
L2M54_13285	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2M54_13290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2M54_13300	COG4774	siderophore transport
L2M54_13305	COG4607	ABC-type enterochelin transport system periplasmic component
L2M54_13310	COG4604	ABC transporter, ATP-binding protein
L2M54_13315	COG4605	iron ion homeostasis
L2M54_13325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2M54_13340	COG2964	Protein conserved in bacteria
L2M54_13350	COG1741	Belongs to the pirin family
L2M54_13475	COG0582	viral genome integration into host DNA
L2M54_13485	COG2879	small protein
L2M54_13490	COG1966	Carbon starvation protein
L2M54_13510	COG4943	cyclic-guanylate-specific phosphodiesterase activity
L2M54_13535	COG1067	ATP-dependent peptidase activity
L2M54_13540	COG0583	DNA-binding transcription factor activity
L2M54_13565	COG1686	Belongs to the peptidase S11 family
L2M54_13570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2M54_13605	COG0616	signal peptide processing
L2M54_13610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2M54_13620	COG0573	inorganic phosphate transmembrane transporter activity
L2M54_13625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2M54_13630	COG1113	amino acid transport
L2M54_13635	COG3961	Belongs to the TPP enzyme family
L2M54_13640	COG1522	sequence-specific DNA binding
L2M54_13650	COG0076	glutamate decarboxylase activity
L2M54_13655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2M54_13685	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2M54_13720	COG0352	thiamine-phosphate diphosphorylase activity
L2M54_13745	COG0612	Peptidase, M16
L2M54_13755	COG1823	symporter activity
L2M54_13760	COG0583	DNA-binding transcription factor activity
L2M54_13765	COG0477	Major facilitator Superfamily
L2M54_13790	COG1187	pseudouridine synthase activity
L2M54_13805	COG1686	Belongs to the peptidase S11 family
L2M54_13810	COG1252	NADH dehydrogenase
L2M54_13820	COG0415	Belongs to the DNA photolyase family
L2M54_13835	COG1215	transferase activity, transferring glycosyl groups
L2M54_13865	COG2070	2-Nitropropane dioxygenase
L2M54_13920	COG0556	nucleotide-excision repair
L2M54_13940	COG0436	Aminotransferase
L2M54_13970	COG4221	oxidoreductase activity
L2M54_13980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
L2M54_13985	COG1381	Involved in DNA repair and RecF pathway recombination
L2M54_13995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2M54_14010	COG0681	Belongs to the peptidase S26 family
L2M54_14025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2M54_14045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2M54_14050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2M54_14055	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2M54_14065	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
L2M54_14070	COG4208	sulfate ABC transporter
L2M54_14075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
L2M54_14080	COG0583	DNA-binding transcription factor activity
L2M54_14085	COG4625	pathogenesis
L2M54_14100	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2M54_14115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2M54_14125	COG1051	belongs to the nudix hydrolase family
L2M54_14125	COG1056	cytidyltransferase-related domain
L2M54_14130	COG1024	Enoyl-CoA hydratase
L2M54_14140	COG2814	Major facilitator Superfamily
L2M54_14145	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2M54_14145	COG0047	phosphoribosylformylglycinamidine synthase activity
L2M54_14170	COG0824	Thioesterase
L2M54_14190	COG0823	Involved in the tonB-independent uptake of proteins
L2M54_14210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2M54_14245	COG0628	permease
L2M54_14255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2M54_14260	COG0596	Alpha beta hydrolase
L2M54_14265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
L2M54_14265	COG0616	signal peptide processing
L2M54_14280	COG1136	(ABC) transporter
L2M54_14285	COG4591	ABC-type transport system involved in lipoprotein release permease component
L2M54_14320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2M54_14340	COG0463	Glycosyl transferase, family 2
L2M54_14370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
L2M54_14375	COG1280	lysine exporter protein (LysE YggA)
L2M54_14380	COG2267	carboxylic ester hydrolase activity
L2M54_14390	COG0019	diaminopimelate decarboxylase activity
L2M54_14400	COG1113	amino acid transport
L2M54_14415	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
L2M54_14425	COG3339	Conserved Protein
L2M54_14430	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2M54_14435	COG0243	molybdopterin cofactor binding
L2M54_14440	COG1929	Belongs to the glycerate kinase type-1 family
L2M54_14455	COG0778	Nitroreductase
L2M54_14470	COG2801	Transposase and inactivated derivatives
L2M54_14500	COG3811	Belongs to the UPF0386 family
L2M54_14510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2M54_14525	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2M54_14545	COG0741	lytic transglycosylase activity
L2M54_14565	COG0584	glycerophosphoryl diester phosphodiesterase
L2M54_14570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2M54_14590	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2M54_14595	COG1597	lipid kinase activity
L2M54_14610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2M54_14615	COG0477	Major facilitator Superfamily
L2M54_14665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2M54_14670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2M54_14695	COG0505	Belongs to the CarA family
L2M54_14715	COG0589	response to stress
L2M54_14730	COG2843	Capsule synthesis protein
L2M54_14740	COG3328	transposase activity
L2M54_14755	COG2321	neutral zinc metallopeptidase
L2M54_14760	COG2354	Protein conserved in bacteria
L2M54_14780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2M54_14805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2M54_14810	COG1053	succinate dehydrogenase
L2M54_14815	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
L2M54_14820	COG2009	succinate dehydrogenase
L2M54_14855	COG2921	Belongs to the UPF0250 family
L2M54_14860	COG0321	lipoyl(octanoyl) transferase activity
L2M54_14875	COG0531	amino acid
L2M54_14885	COG1733	regulation of RNA biosynthetic process
L2M54_14890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2M54_14895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2M54_14895	COG1648	precorrin-2 dehydrogenase activity
L2M54_14910	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2M54_14940	COG0671	phosphoesterase, PA-phosphatase related
L2M54_14945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2M54_14955	COG1538	Outer membrane efflux protein
L2M54_14960	COG0393	Putative heavy-metal-binding
L2M54_14975	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_14985	COG0525	valine-tRNA ligase activity
L2M54_15005	COG0583	DNA-binding transcription factor activity
L2M54_15010	COG0004	ammonium transporteR
L2M54_15020	COG0642	Histidine kinase
L2M54_15025	COG0745	RESPONSE REGULATOR receiver
L2M54_15030	COG2194	sulfuric ester hydrolase activity
L2M54_15050	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2M54_15065	COG2315	Protein conserved in bacteria
L2M54_15070	COG0142	geranyltranstransferase activity
L2M54_15075	COG2828	Protein conserved in bacteria
L2M54_15080	COG1113	amino acid transport
L2M54_15100	COG2207	Transcriptional regulator
L2M54_15125	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2M54_15135	COG0560	Phosphoserine phosphatase
L2M54_15145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2M54_15155	COG1530	ribonuclease E activity
L2M54_15160	COG0424	maF-like protein
L2M54_15165	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2M54_15170	COG1792	Involved in formation and maintenance of cell shape
L2M54_15175	COG1077	Cell shape determining protein MreB Mrl
L2M54_15180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2M54_15190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2M54_15215	COG3590	peptidase
L2M54_15220	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
L2M54_15225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2M54_15230	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2M54_15235	COG1115	amino acid carrier protein
L2M54_15260	COG1289	transmembrane transporter activity
L2M54_15270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2M54_15310	COG1376	ErfK ybiS ycfS ynhG family protein
L2M54_15315	COG2832	Protein of unknown function (DUF454)
L2M54_15325	COG5510	response to toxic substance
L2M54_15350	COG0840	transmembrane signaling receptor activity
L2M54_15390	COG3422	double-strand break repair
L2M54_15395	COG2824	Alkylphosphonate utilization operon protein PhnA
L2M54_15400	COG3189	MarR family transcriptional regulator
L2M54_15410	COG0354	folic acid binding
L2M54_15415	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2M54_15425	COG0679	Auxin Efflux Carrier
L2M54_15430	COG1902	pentaerythritol trinitrate reductase activity
L2M54_15435	COG4772	TonB-dependent receptor
L2M54_15440	COG2094	Belongs to the DNA glycosylase MPG family
L2M54_15465	COG1217	gtp-binding protein TYPA
L2M54_15480	COG0833	amino acid
L2M54_15485	COG1690	Belongs to the RtcB family
L2M54_15495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
L2M54_15495	COG2885	chlorophyll binding
L2M54_15505	COG0183	Belongs to the thiolase family
L2M54_15525	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2M54_15545	COG2207	Transcriptional regulator
L2M54_15550	COG0183	Belongs to the thiolase family
L2M54_15580	COG1272	protein, Hemolysin III
L2M54_15585	COG0477	Major facilitator Superfamily
L2M54_15600	COG0450	alkyl hydroperoxide reductase
L2M54_15620	COG0285	dihydrofolate synthase activity
L2M54_15670	COG2096	Adenosyltransferase
L2M54_15690	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
L2M54_15695	COG0745	RESPONSE REGULATOR receiver
L2M54_15700	COG2205	protein histidine kinase activity
L2M54_15710	COG1960	acyl-CoA dehydrogenase activity
L2M54_15715	COG1960	acyl-CoA dehydrogenase activity
L2M54_15765	COG1215	transferase activity, transferring glycosyl groups
L2M54_15780	COG1091	dTDP-4-dehydrorhamnose reductase activity
L2M54_15795	COG0438	transferase activity, transferring glycosyl groups
L2M54_15800	COG0726	polysaccharide deacetylase
L2M54_15815	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
L2M54_15820	COG2205	protein histidine kinase activity
L2M54_15850	COG1862	Preprotein translocase
L2M54_15860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2M54_15870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2M54_15880	COG3781	membrane
L2M54_15885	COG0613	PHP domain protein
L2M54_15895	COG2350	Protein conserved in bacteria
L2M54_15925	COG1607	acyl-coa hydrolase
L2M54_15985	COG2199	diguanylate cyclase activity
L2M54_15995	COG1408	metallophosphoesterase
L2M54_16000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2M54_16010	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2M54_16030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2M54_16035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2M54_16050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2M54_16060	COG2969	positive regulation of protein catabolic process
L2M54_16080	COG1960	acyl-CoA dehydrogenase activity
L2M54_16100	COG1309	transcriptional regulator
L2M54_16105	COG1960	acyl-CoA dehydrogenase activity
L2M54_16150	COG1183	phosphatidylcholine synthase activity
L2M54_16155	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
L2M54_16185	COG0741	lytic transglycosylase activity
L2M54_16185	COG0739	heme binding
L2M54_16185	COG1196	nuclear chromosome segregation
L2M54_16200	COG1702	phosphate starvation-inducible protein PhoH
L2M54_16235	COG1295	ribonuclease BN
L2M54_16240	COG0697	spore germination
L2M54_16245	COG2169	Transcriptional regulator
L2M54_16250	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2M54_16295	COG0557	exoribonuclease II activity
L2M54_16300	COG0339	signal peptide processing
L2M54_16305	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
L2M54_16335	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
L2M54_16340	COG1960	acyl-CoA dehydrogenase activity
L2M54_16495	COG0626	cystathionine gamma-synthase activity
L2M54_16500	COG0433	COG0433 Predicted ATPase
L2M54_16510	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2M54_16510	COG1017	nitric oxide dioxygenase activity
L2M54_16515	COG1959	2 iron, 2 sulfur cluster binding
L2M54_16530	COG1301	dicarboxylic acid transport
L2M54_16535	COG1946	Acyl-CoA thioesterase
L2M54_16555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2M54_16560	COG1040	competence protein
L2M54_16565	COG0494	nUDIX hydrolase
L2M54_16575	COG0598	Magnesium transport protein CorA
L2M54_16585	COG2854	intermembrane phospholipid transfer
L2M54_16595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
L2M54_16600	COG1127	ABC transporter
L2M54_16610	COG0513	Belongs to the DEAD box helicase family
L2M54_16630	COG0408	coproporphyrinogen oxidase activity
L2M54_16645	COG1960	acyl-CoA dehydrogenase activity
L2M54_16655	COG1983	PspC domain protein
L2M54_16660	COG0517	IMP dehydrogenase activity
L2M54_16695	COG1106	Psort location Cytoplasmic, score
L2M54_16720	COG0583	DNA-binding transcription factor activity
L2M54_16760	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_16770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2M54_16775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2M54_16780	COG0833	amino acid
L2M54_16810	COG1192	Involved in chromosome partitioning
L2M54_16815	COG0628	permease
L2M54_16825	COG1289	transmembrane transporter activity
L2M54_16840	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2M54_16845	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2M54_16855	COG0277	FAD linked oxidase domain protein
L2M54_16860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2M54_16885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2M54_16890	COG5380	lipid catabolic process
L2M54_16910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2M54_16960	COG0194	GDP metabolic process
L2M54_16975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2M54_16995	COG3307	-O-antigen
L2M54_17015	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
L2M54_17020	COG1704	LemA family
L2M54_17030	COG0493	'glutamate synthase
L2M54_17035	COG0070	glutamate synthase
L2M54_17035	COG0069	glutamate synthase activity
L2M54_17035	COG0067	glutamate synthase
L2M54_17085	COG2226	methyltransferase
L2M54_17100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2M54_17105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2M54_17215	COG0488	(ABC) transporter
L2M54_17220	COG2873	o-acetylhomoserine
L2M54_17225	COG4221	oxidoreductase activity
L2M54_17230	COG0659	secondary active sulfate transmembrane transporter activity
L2M54_17255	COG0427	acetyl-CoA hydrolase
L2M54_17300	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2M54_17340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2M54_17395	COG0582	viral genome integration into host DNA
L2M54_17420	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2M54_17485	COG2814	Major facilitator Superfamily
L2M54_17560	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2M54_17565	COG1733	regulation of RNA biosynthetic process
L2M54_17595	COG0667	Aldo Keto reductase
L2M54_17615	COG0583	DNA-binding transcription factor activity
L2M54_17620	COG2814	Major facilitator Superfamily
L2M54_17650	COG1335	isochorismatase
L2M54_17660	COG1012	belongs to the aldehyde dehydrogenase family
L2M54_17665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2M54_17675	COG1113	amino acid transport
L2M54_17685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2M54_17700	COG2814	Major facilitator Superfamily
L2M54_17710	COG0351	phosphomethylpyrimidine kinase
L2M54_17710	COG0352	thiamine-phosphate diphosphorylase activity
L2M54_17710	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2M54_17730	COG1309	transcriptional regulator
L2M54_17735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2M54_17750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2M54_17760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2M54_17765	COG3162	membrane
L2M54_17770	COG2205	protein histidine kinase activity
L2M54_17770	COG2198	Histidine kinase
L2M54_17770	COG0784	Response regulator, receiver
L2M54_17795	COG1522	sequence-specific DNA binding
L2M54_17800	COG1335	isochorismatase
L2M54_17805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2M54_17815	COG0668	transmembrane transport
L2M54_17820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2M54_17825	COG1519	Transferase
L2M54_17830	COG1902	pentaerythritol trinitrate reductase activity
L2M54_17850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2M54_17875	COG0426	domain, Protein
L2M54_17875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2M54_17880	COG4774	siderophore transport
L2M54_17885	COG2119	membrane
L2M54_17895	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2M54_17905	COG4942	peptidase
L2M54_17920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2M54_17930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2M54_17950	COG0189	ligase activity
L2M54_17990	COG0708	Exodeoxyribonuclease III
L2M54_17995	COG1393	Belongs to the ArsC family
L2M54_18010	COG3706	GGDEF domain
L2M54_18045	COG2351	hydroxyisourate hydrolase activity
L2M54_18050	COG2233	PERMEase
L2M54_18060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2M54_18070	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
L2M54_18075	COG1028	Short-chain dehydrogenase reductase Sdr
L2M54_18085	COG3150	esterase
L2M54_18130	COG3409	Peptidoglycan-binding domain 1 protein
L2M54_18130	COG5632	N-Acetylmuramoyl-L-alanine amidase
L2M54_18130	COG1388	LysM domain
L2M54_18145	COG2918	glutathione biosynthetic process
L2M54_18160	COG2733	membrane
L2M54_18165	COG0436	Aminotransferase
L2M54_18170	COG0534	Mate efflux family protein
L2M54_18255	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2M54_18260	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2M54_18270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2M54_18280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2M54_18295	COG0010	Belongs to the arginase family
L2M54_18325	COG2188	Transcriptional regulator
L2M54_18335	COG0523	cobalamin synthesis protein
L2M54_18345	COG1113	amino acid transport
L2M54_18355	COG0625	glutathione transferase activity
L2M54_18375	COG1683	Conserved Protein
L2M54_18380	COG0534	Mate efflux family protein
L2M54_18385	COG0385	Bile acid
L2M54_18390	COG1335	isochorismatase
L2M54_18395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2M54_18415	COG2116	formate transmembrane transporter activity
L2M54_18420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2M54_18425	COG2133	pyrroloquinoline quinone binding
L2M54_18430	COG2983	Belongs to the UPF0260 family
L2M54_18450	COG1194	a g-specific adenine glycosylase
L2M54_18465	COG2818	Glycosylase
L2M54_18470	COG1064	alcohol dehydrogenase
L2M54_18475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2M54_18490	COG0583	DNA-binding transcription factor activity
L2M54_18495	COG0656	L-ascorbic acid biosynthetic process
L2M54_18500	COG2814	Major facilitator Superfamily
L2M54_18530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2M54_18535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2M54_18550	COG2233	PERMEase
L2M54_18555	COG0583	DNA-binding transcription factor activity
L2M54_18590	COG0733	neurotransmitter:sodium symporter activity
L2M54_18630	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2M54_18635	COG0657	acetylesterase activity
L2M54_18655	COG0583	DNA-binding transcription factor activity
L2M54_18685	COG2951	lytic endotransglycosylase activity
L2M54_18690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2M54_18705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2M54_18715	COG0671	phosphoesterase, PA-phosphatase related
L2M54_18720	COG0861	Integral membrane protein TerC family
L2M54_18730	COG0754	glutathionylspermidine amidase activity
L2M54_18740	COG0402	S-adenosylhomocysteine deaminase activity
L2M54_18755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2M54_18760	COG1230	cation diffusion facilitator family transporter
L2M54_18775	COG0706	membrane insertase activity