locus-tag class description G3R47_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G3R47_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3R47_00030 ENOG4105DQR SNARE associated Golgi G3R47_00035 ENOG4105C5H ABC transporter G3R47_00040 ENOG4108821 RND type efflux pump G3R47_00045 ENOG4108821 RND type efflux pump G3R47_00050 ENOG4108821 RND type efflux pump G3R47_00060 ENOG4105D74 hydrolase G3R47_00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) G3R47_00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G3R47_00120 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase G3R47_00130 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G3R47_00135 ENOG4105DTN riboflavin biosynthesis protein ribF G3R47_00145 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) G3R47_00150 ENOG4108R86 Transcriptional regulator G3R47_00155 ENOG4108VM9 ABC, transporter G3R47_00160 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3R47_00165 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G3R47_00170 ENOG4105GVF (ABC) transporter G3R47_00175 ENOG4105GVF (ABC) transporter G3R47_00180 ENOG4107QZM n-acetylglutamate synthase G3R47_00195 ENOG4105UBK short-chain dehydrogenase reductase G3R47_00200 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G3R47_00210 ENOG4108Z33 Thiol disulfide Interchange Protein G3R47_00215 ENOG41062JF Transcriptional regulator G3R47_00240 ENOG4105HSS phospholipase C G3R47_00250 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G3R47_00255 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G3R47_00260 ENOG4105CJR Integral membrane protein (MviN G3R47_00265 ENOG4108V1T peptidylprolyl cis-trans isomerase G3R47_00270 ENOG4108V1T peptidylprolyl cis-trans isomerase G3R47_00275 ENOG4105D75 Capsular exopolysaccharide family G3R47_00285 ENOG4105DAY polysaccharide export protein G3R47_00290 ENOG4107QQG Dehydrogenase G3R47_00300 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G3R47_00305 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase G3R47_00310 ENOG4105D2T synthase G3R47_00325 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G3R47_00330 ENOG4105F0R Cytidylyltransferase G3R47_00370 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G3R47_00385 ENOG4107UKG Glycosyl transferase, family 4 G3R47_00390 ENOG4105D3Q Sugar transferase G3R47_00395 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G3R47_00400 ENOG4105C6Y Udp-glucose 6-dehydrogenase G3R47_00410 ENOG4105CMR udp-glucose 4-epimerase G3R47_00415 ENOG4107QKV phosphomannomutase G3R47_00420 ENOG4105DAA L-lactate G3R47_00425 ENOG41073TP transcriptional regulator G3R47_00435 ENOG4105CXG d-lactate dehydrogenase G3R47_00440 ENOG4105CGF Aromatic amino acid aminotransferase G3R47_00450 ENOG4105DRR Transcriptional regulator, GntR family G3R47_00455 ENOG4105CR4 methylisocitrate lyase G3R47_00460 ENOG4105BZN citrate synthase G3R47_00465 ENOG4108I0Z Aconitate hydratase G3R47_00550 ENOG4105D3G Pseudouridine synthase G3R47_00575 ENOG4105EW9 transcriptional regulator AsnC family G3R47_00590 ENOG4105M4H endoribonuclease L-psp G3R47_00595 ENOG4105C85 amino acid G3R47_00600 ENOG4105C85 amino acid G3R47_00610 ENOG4105C26 Dehydrogenase G3R47_00615 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3R47_00625 ENOG4105C1G acyl-Coa dehydrogenase G3R47_00630 ENOG4105E39 Enoyl-CoA hydratase G3R47_00635 ENOG4105E39 Enoyl-CoA hydratase G3R47_00640 ENOG4105CSH Transporter G3R47_00775 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G3R47_00790 ENOG4108BUD transposase G3R47_00880 ENOG4105ZTP Protein of unknown function (DUF1376) G3R47_00900 ENOG4107NTZ G3R47_00915 ENOG4107PSF BolA-like protein G3R47_00925 ENOG4107QJE Chromosome Partitioning Protein G3R47_00940 ENOG4105DQR SNARE associated Golgi G3R47_00945 ENOG4108VBZ doxx family G3R47_00950 ENOG4106MP8 UPF0754 membrane protein G3R47_00955 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G3R47_00975 ENOG4105EUB pirin domain protein G3R47_01000 ENOG4107R1I NAD-dependent malic enzyme G3R47_01010 ENOG4105EZR dyp-type peroxidase family protein G3R47_01015 ENOG410829K Lysine exporter protein (Lyse ygga) G3R47_01020 ENOG4105FAV ABC, transporter G3R47_01025 ENOG4105FDK ABC transporter G3R47_01085 ENOG41090VV Protein of unknown function (DUF2846) G3R47_01095 ENOG4108V06 Glutathione peroxidase G3R47_01105 ENOG4107RTG Major Facilitator superfamily G3R47_01110 ENOG4108IND Tetr family transcriptional regulator G3R47_01125 ENOG4105C79 DNA protecting protein DprA G3R47_01160 ENOG4105Y7M Transcriptional regulator, TetR family G3R47_01195 ENOG4105C6T cysteine synthase G3R47_01205 ENOG4105CS1 NAD(P)H quinone oxidoreductase G3R47_01225 ENOG4105CCT upf0313 protein G3R47_01240 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G3R47_01250 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3R47_01255 ENOG4108URH decarboxylase G3R47_01260 ENOG4105EE5 Membrane protein terC G3R47_01265 ENOG4105K5B UPF0225 protein G3R47_01270 ENOG4105EN6 Membrane G3R47_01275 ENOG41079KZ Major Facilitator Superfamily G3R47_01280 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3R47_01285 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_01300 ENOG4105F0N pyrophosphate phospho-hydrolase G3R47_01305 ENOG41090KI Outer membrane porin G3R47_01315 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3R47_01320 ENOG4105FB2 class II Aldolase G3R47_01325 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_01330 ENOG4105C0P Mg chelatase subunit ChlI G3R47_01380 ENOG4105GR3 Histidine kinase G3R47_01395 ENOG4105E3B Multicopper oxidase G3R47_01415 ENOG4105CE1 Ferrous iron transport protein b G3R47_01440 ENOG4105C0P Mg chelatase subunit ChlI G3R47_01455 ENOG4105BZU Histidine kinase G3R47_01465 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G3R47_01505 ENOG4108K5H permease YjgP YjgQ family protein G3R47_01510 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G3R47_01515 ENOG4105CN1 protease G3R47_01520 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3R47_01525 ENOG4107TUY Histidine kinase G3R47_01535 ENOG41061WM D-Alanyl-D-Alanine G3R47_01545 ENOG4105D6E homoserine dehydrogenase G3R47_01550 ENOG4105T95 Thiol disulfide interChange protein G3R47_01555 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3R47_01565 ENOG4105CE1 Ferrous iron transport protein b G3R47_01580 ENOG4105CNI cell division protein FtsW G3R47_01585 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G3R47_01595 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G3R47_01625 ENOG4105DFG type I secretion outer membrane protein G3R47_01630 ENOG4108UTW Plays a role in the regulation of phosphate uptake G3R47_01645 ENOG4108HRK Histidine kinase G3R47_01650 ENOG4108NEV two component transcriptional regulator, LytTR family G3R47_01655 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G3R47_01680 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS G3R47_01695 ENOG4105GVR general secretion pathway protein D G3R47_01700 ENOG4105TV9 FHA Domain-Containing protein G3R47_01705 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G3R47_01745 ENOG4105PM1 preprotein translocase subunit SecE G3R47_01750 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G3R47_01800 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G3R47_01805 ENOG4105D3Y Na H antiporter G3R47_01820 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G3R47_01835 ENOG4107ZXU DSBA oxidoreductase G3R47_01895 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase G3R47_01900 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G3R47_01930 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G3R47_01940 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G3R47_01955 ENOG4105C2N RNA methyltransferase TrmH family group 3 G3R47_01965 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G3R47_01990 ENOG4107EJC Preprotein translocase subunit SecG G3R47_02015 ENOG4105CHV Transcription elongation factor NusA G3R47_02030 ENOG4105KJM monovalent cation h antiporter subunit g G3R47_02035 ENOG4105W4C monovalent cation H antiporter subunit F G3R47_02040 ENOG4105SC1 monovalent cation H antiporter subunit E G3R47_02045 ENOG4107R4Z monovalent cation h antiporter subunit d G3R47_02050 ENOG4108ZE9 Monovalent cation H antiporter subunit C G3R47_02055 ENOG4105D65 subunit l G3R47_02070 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G3R47_02075 ENOG41061H0 Monooxygenase G3R47_02090 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G3R47_02100 ENOG4105CSR polyphosphate kinase 2 G3R47_02110 ENOG4105DSY exodeoxyribonuclease V, gamma G3R47_02115 ENOG4107QKA exodeoxyribonuclease V beta G3R47_02120 ENOG4107QYX exodeoxyribonuclease v alpha G3R47_02140 ENOG4107QUT magnesium and cobalt transport protein CorA G3R47_02145 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) G3R47_02150 ENOG4105DVC DnaJ domain protein G3R47_02165 ENOG4105CKD glutathione-regulated potassium-efflux system protein G3R47_02170 ENOG4105C25 Primosomal protein n' G3R47_02175 ENOG4105D7Q type ii secretion system G3R47_02180 ENOG4108VAU general secretion pathway protein G G3R47_02195 ENOG4108Z7R Chaperone CsaA G3R47_02200 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G3R47_02205 ENOG4108JU5 Magnesium and cobalt efflux protein G3R47_02210 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) G3R47_02220 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G3R47_02230 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G3R47_02245 ENOG4105C5X domain protein G3R47_02250 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) G3R47_02260 ENOG4105BZ8 glutamate synthase G3R47_02295 ENOG4107T8P acyl-Coa dehydrogenase G3R47_02305 ENOG4107QI1 Mate efflux family protein G3R47_02315 ENOG4105CSA Coproporphyrinogen iii oxidase G3R47_02320 ENOG4105EMU Dehydrogenase G3R47_02325 ENOG4105CBN LysR family transcriptional regulator G3R47_02340 ENOG4105J5T Amp-dependent synthetase and ligase G3R47_02345 ENOG4105C03 ribonuclease G3R47_02350 ENOG4105EI2 Pseudouridine synthase G3R47_02355 ENOG4107XGZ Hydrolase G3R47_02360 ENOG4105D29 Helix-turn-helix type 11 domain protein G3R47_02375 ENOG4108W5M transcriptional regulator G3R47_02390 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase G3R47_02415 ENOG4105DUM transcriptional regulator, lysR family G3R47_02440 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3R47_02495 ENOG4105CK2 sodium dicarboxylate symporter G3R47_02505 ENOG4105D1S lipid A biosynthesis G3R47_02510 ENOG4105N14 lysine exporter protein LysE YggA G3R47_02515 ENOG4105C5H ABC transporter G3R47_02530 ENOG4105KVH Transcriptional regulator G3R47_02540 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G3R47_02555 ENOG4105C4R Atp-dependent dna helicase G3R47_02560 ENOG4105VFU Rna-binding protein G3R47_02580 ENOG4105CKD glutathione-regulated potassium-efflux system protein G3R47_02595 ENOG4107RGH Aldehyde dehydrogenase G3R47_02605 ENOG4105CIY formyltetrahydrofolate deformylase G3R47_02755 ENOG4105DWV Homoserine O-trans-acetylase G3R47_02765 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G3R47_02775 ENOG4108ESX Receptor G3R47_02785 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G3R47_02805 ENOG4107GFK fumarate G3R47_02810 ENOG4108DNC Involved in acetate metabolism (By similarity) G3R47_02815 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G3R47_02820 ENOG4105C01 Dihydroxy-acid dehydratase G3R47_02825 ENOG4108UHU Aldolase G3R47_02830 ENOG4105C6Z Gluconate G3R47_02835 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G3R47_02840 ENOG4105C26 Dehydrogenase G3R47_02850 ENOG4106HB6 Alpha beta hydrolase G3R47_02865 ENOG4105CN1 protease G3R47_02880 ENOG4105WVQ Fe-S assembly protein IscX G3R47_02900 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) G3R47_02920 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G3R47_02940 ENOG4105VW4 glutaredoxin 3 G3R47_02950 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G3R47_02955 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) G3R47_02965 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G3R47_02970 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3R47_02975 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G3R47_02980 ENOG4105DJY efflux transporter, rnd family, mfp subunit G3R47_03005 ENOG4105C7K acetolactate synthase G3R47_03010 ENOG4108ZP8 Acetolactate synthase small subunit G3R47_03020 ENOG4105BZU Histidine kinase G3R47_03040 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) G3R47_03055 ENOG4105F8V Hydrolase, tatD family G3R47_03060 ENOG4107QM5 aconitate hydratase G3R47_03065 ENOG4105CUZ uba thif-type nad fad binding protein G3R47_03085 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G3R47_03100 ENOG4106UX7 integral membrane protein G3R47_03105 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G3R47_03110 ENOG4105W8H transhydrogenase (subunit alpha G3R47_03115 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G3R47_03130 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G3R47_03135 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3R47_03140 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G3R47_03145 ENOG4105BZU Histidine kinase G3R47_03150 ENOG4105C6T cysteine synthase G3R47_03165 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3R47_03175 ENOG4105DXN mazG family G3R47_03180 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein G3R47_03185 ENOG4105DJ0 Poly(A) Polymerase G3R47_03190 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G3R47_03210 ENOG41080Z8 PHOSPHOCARRIER protein G3R47_03215 ENOG4105N42 UPF0307 protein G3R47_03220 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_03235 ENOG4105CYM Glutathione S-transferase G3R47_03240 ENOG4105W39 Membrane G3R47_03280 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G3R47_03300 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G3R47_03310 ENOG4105C9X ppx gppa phosphatase G3R47_03320 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G3R47_03325 ENOG4105II7 pyrroline-5-carboxylate reductase G3R47_03330 ENOG4108VIA integral membrane protein G3R47_03335 ENOG4105C2M dna polymerase I G3R47_03355 ENOG4107QHF type ii secretion system protein e G3R47_03360 ENOG4108ZHJ Organic hydroperoxide resistance protein G3R47_03365 ENOG4105K56 Transcriptional regulator G3R47_03435 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G3R47_03440 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G3R47_03445 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G3R47_03455 ENOG4105CRQ synthase (Component I) G3R47_03500 ENOG4108Z0R Transferase G3R47_03505 ENOG41072GX Peptidase M22 Glycoprotease G3R47_03520 ENOG4105C4W S-formylglutathione hydrolase G3R47_03530 ENOG4105DJV ribulose-phosphate 3-epimerase G3R47_03535 ENOG4108HCJ Hydrolase G3R47_03545 ENOG4105E3B Multicopper oxidase G3R47_03550 ENOG4105VR0 copper resistance G3R47_03565 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G3R47_03570 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G3R47_03575 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G3R47_03610 ENOG4105ETT transcriptional Regulator, LysR family G3R47_03615 ENOG4105C1G acyl-Coa dehydrogenase G3R47_03620 ENOG4107RGD Major Facilitator superfamily G3R47_03625 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3R47_03635 ENOG4107EFR Flavocytochrome c G3R47_03640 ENOG4106P55 Transcriptional regulator G3R47_03655 ENOG4106P55 Transcriptional regulator G3R47_03665 ENOG4105CH2 amidohydrolase G3R47_03685 ENOG4105ETT transcriptional Regulator, LysR family G3R47_03700 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) G3R47_03735 ENOG4105JAB phenazine biosynthesis protein, phzf family G3R47_03745 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3R47_03755 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G3R47_03765 ENOG4107EXC regulatoR G3R47_03770 ENOG4105E0F Histidine kinase G3R47_03780 ENOG4105BZU Histidine kinase G3R47_03800 ENOG4105GKE subunit e G3R47_03805 ENOG4107QIZ NADH dehydrogenase G3R47_03810 ENOG4108IEH NADH dehydrogenase subunit g G3R47_03825 ENOG4107UFS subunit j G3R47_03835 ENOG4105D65 subunit l G3R47_03840 ENOG4105C8S subunit m G3R47_03860 ENOG4105DUM transcriptional regulator, lysR family G3R47_03865 ENOG4105DP0 ferredoxin-NADP reductase G3R47_03890 ENOG4105CBX hi0933 family G3R47_03895 ENOG4105K6H D-cysteine desulfhydrase G3R47_03925 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G3R47_03935 ENOG4105D1F ATP-binding protein G3R47_03985 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) G3R47_03995 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G3R47_04010 ENOG4105HF0 Membrane G3R47_04020 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G3R47_04040 ENOG4106UW1 Major Facilitator superfamily G3R47_04045 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G3R47_04050 ENOG4108K4C ec 3.1.3.12 G3R47_04055 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G3R47_04065 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G3R47_04070 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G3R47_04080 ENOG4105FE9 pseudouridine synthase G3R47_04085 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G3R47_04090 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) G3R47_04095 ENOG4107RTD sua5 ycio yrdc ywlc family protein G3R47_04100 ENOG4108BPE -transporting atpase G3R47_04105 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G3R47_04115 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G3R47_04120 ENOG4105CHR reductase G3R47_04130 ENOG4109066 lysm domain bon superfamily protein G3R47_04135 ENOG4105DWF phosphomethylpyrimidine kinase G3R47_04145 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G3R47_04175 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G3R47_04205 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) G3R47_04220 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G3R47_04225 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G3R47_04230 ENOG4105C34 Pseudouridine synthase G3R47_04235 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G3R47_04270 ENOG41076J9 exonuclease VIII G3R47_04310 ENOG4108XTP Transcriptional regulator G3R47_04490 ENOG4105DFP Integrase G3R47_04500 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G3R47_04520 ENOG4105EJC lysr family transcriptional regulator G3R47_04525 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G3R47_04530 ENOG4105C94 Transporter G3R47_04540 ENOG4105DVW rieske (2Fe-2S) G3R47_04545 ENOG4105C26 Dehydrogenase G3R47_04550 ENOG4105E3J oxidoreductase G3R47_04565 ENOG4105C4K Nad synthetase G3R47_04575 ENOG4105EUB pirin domain protein G3R47_04580 ENOG4108YXA Membrane G3R47_04625 ENOG4105KEG ribosomal-protein-alanine acetyltransferase G3R47_04635 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) G3R47_04640 ENOG4105C3M thioredoxin reductase G3R47_04645 ENOG4105CNU cell division protein FtsK G3R47_04650 ENOG4105CCF Lysine exporter protein (Lyse ygga) G3R47_04665 ENOG4107QMS site-determining protein G3R47_04680 ENOG4106HNH Acyl-transferase G3R47_04685 ENOG4108ZG0 Ompa motb domain protein G3R47_04690 ENOG4105C4R Atp-dependent dna helicase G3R47_04700 ENOG4107QKV phosphomannomutase G3R47_04715 ENOG4105E7A Glutamine amidotransferase G3R47_04740 ENOG41090R7 Ferric uptake G3R47_04745 ENOG4105CZX twitching motility protein G3R47_04750 ENOG4105CZX twitching motility protein G3R47_04755 ENOG4105DFA alanine racemase domain protein G3R47_04760 ENOG4105EYH Exonuclease G3R47_04765 ENOG4107RH8 nuclease SbcCD subunit D G3R47_04785 ENOG4105ECP epimerase G3R47_04790 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3R47_04795 ENOG4105D52 delta-aminolevulinic acid dehydratase G3R47_04800 ENOG4108VUY thioesterase Superfamily protein G3R47_04805 ENOG4105CW7 secretion protein, HlyD family G3R47_04810 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3R47_04815 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G3R47_04825 ENOG4105DFP Integrase G3R47_04860 ENOG4105C54 Major Facilitator superfamily G3R47_04865 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3R47_04875 ENOG4108SF5 RNA Polymerase G3R47_04905 ENOG4108YNN Heme oxygenase G3R47_04930 ENOG4105D5Q Arginine ornithine antiporter G3R47_04935 ENOG4107QK5 Homocysteine s-methyltransferase G3R47_04960 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) G3R47_04965 ENOG4105C94 Transporter G3R47_04970 ENOG4105C94 Transporter G3R47_04980 ENOG4108S4H thioesterase Superfamily protein G3R47_04990 ENOG4105CKI cobalamin synthesis protein G3R47_05000 ENOG4108VWS Yaeq family G3R47_05010 ENOG4107BJW polysaccharide deacetylase G3R47_05015 ENOG4105CND Glycosyl transferase, family 2 G3R47_05025 ENOG4106YT9 Enoyl-CoA hydratase G3R47_05040 ENOG41069M3 Transcriptional regulator G3R47_05060 ENOG4105CHR reductase G3R47_05075 ENOG4105DJB Major Facilitator Superfamily G3R47_05085 ENOG4108MXF Alpha Beta Hydrolase G3R47_05090 ENOG4105CHR reductase G3R47_05105 ENOG4105C7K acetolactate synthase G3R47_05115 ENOG4105CSH Transporter G3R47_05120 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G3R47_05125 ENOG4105CSV Glutaminase G3R47_05130 ENOG4108R6W Transcriptional regulator, ARAC family G3R47_05135 ENOG4105EU0 Major facilitator Superfamily G3R47_05140 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) G3R47_05155 ENOG4105C3R Methionine synthase G3R47_05160 ENOG4105CJ3 phosphate transporter G3R47_05180 ENOG4105E6M Sulphatase-modifying factor protein G3R47_05185 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G3R47_05200 ENOG4107RNH Outer membrane receptor FepA G3R47_05220 ENOG4108UJV acyl-CoA thioesterase i G3R47_05225 ENOG4108I0Y (ABC) transporter G3R47_05230 ENOG4105CV6 ABC transporter, permease G3R47_05235 ENOG4107U91 Rhomboid family G3R47_05260 ENOG4105C5Q Transcriptional regulator G3R47_05270 ENOG4107QZF nitrite reductase NADPH large subunit G3R47_05275 ENOG4105VCQ rubredoxin G3R47_05295 ENOG4108MRJ G3R47_05310 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) G3R47_05325 ENOG4105D4T Citrate transporter G3R47_05330 ENOG4105C37 (CBS) domain G3R47_05340 ENOG4107RET Isocitrate lyase G3R47_05370 ENOG4105CQM Urea amidohydrolase subunit alpha G3R47_05380 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) G3R47_05395 ENOG4106H78 methyltransferase G3R47_05400 ENOG4105CJN penicillin-binding protein G3R47_05425 ENOG4105CSM endonuclease III G3R47_05430 ENOG4108R3D Electron transport complex G3R47_05435 ENOG4105D82 Glutamate dehydrogenase G3R47_05445 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G3R47_05465 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G3R47_05505 ENOG4107RAQ aminopeptidase G3R47_05510 ENOG4105D0A hydroxylase G3R47_05515 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G3R47_05535 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G3R47_05540 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) G3R47_05550 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G3R47_05560 ENOG4105W4M Transport-associated protein G3R47_05570 ENOG4105E09 nadh pyrophosphatase G3R47_05580 ENOG4107RZZ dna polymerase iii epsilon subunit G3R47_05585 ENOG4105E9H Lytic Murein transglycosylase G3R47_05595 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G3R47_05600 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G3R47_05605 ENOG4108JQ5 ABC transporter G3R47_05625 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) G3R47_05655 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3R47_05670 ENOG4108M3P Membrane G3R47_05675 ENOG4105D01 (LipO)protein G3R47_05690 ENOG4106B0W Curli production assembly transport component CsgG G3R47_05700 ENOG4107Y60 (LipO)protein G3R47_05710 ENOG4105C85 amino acid G3R47_05720 ENOG4105CUB amino acid G3R47_05740 ENOG4105C26 Dehydrogenase G3R47_05760 ENOG4105C85 amino acid G3R47_05765 ENOG4105D5K Hemolysin activator protein G3R47_05770 ENOG4105CKT filamentous hemagglutinin G3R47_05790 ENOG4107RGH Aldehyde dehydrogenase G3R47_05795 ENOG4108ZX5 transcriptional regulator G3R47_05800 ENOG4105DJP Membrane G3R47_05805 ENOG4105CTX dehydratase G3R47_05810 ENOG4105DJB Major Facilitator Superfamily G3R47_05815 ENOG4105EQX glucarate dehydratase G3R47_05825 ENOG4105CZJ Aldehyde dehydrogenase G3R47_05830 ENOG4105JXH GntR family transcriptional regulator G3R47_05845 ENOG4105NI3 Protein of unknown function (DUF3237) G3R47_05850 ENOG4105EPF Outer membrane porin G3R47_05855 ENOG4105C1G acyl-Coa dehydrogenase G3R47_05870 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase G3R47_05875 ENOG4108SC4 )-transporter G3R47_05890 ENOG4105E3J oxidoreductase G3R47_05905 ENOG4105E6M Sulphatase-modifying factor protein G3R47_05910 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) G3R47_05915 ENOG4105D2S major facilitator superfamily G3R47_05920 ENOG4105EPF Outer membrane porin G3R47_05940 ENOG4107RN6 Monooxygenase G3R47_05950 ENOG4105JQZ Methyltransferase G3R47_05955 ENOG4105F95 Monooxygenase G3R47_05990 ENOG4105F95 Monooxygenase G3R47_06000 ENOG4105C7N Xanthine uracil vitamin C permease G3R47_06005 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3R47_06010 ENOG4105CPW cytochrome b561 G3R47_06020 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G3R47_06030 ENOG4105CFH Aspartokinase G3R47_06335 ENOG4105DIJ Phosphoethanolamine transferase G3R47_06340 ENOG4105DFP Integrase G3R47_06350 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G3R47_06360 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G3R47_06375 ENOG4105CPC Aldo Keto reductase G3R47_06380 ENOG4107RYR Transcriptional regulator, Crp Fnr family G3R47_06385 ENOG4108UKZ OsmC family G3R47_06400 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3R47_06430 ENOG4105CD3 dihydroorotase G3R47_06435 ENOG4108ZG0 Ompa motb domain protein G3R47_06445 ENOG4108TGY Glutathione S-transferase G3R47_06450 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G3R47_06460 ENOG4108K3A Glutathione S-transferase G3R47_06470 ENOG4108JU3 Alkyl hydroperoxide reductase G3R47_06480 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) G3R47_06490 ENOG4105D3R alkyl hydroperoxide reductase G3R47_06495 ENOG4105CQ7 ATP-dependent helicase G3R47_06510 ENOG4105D2S major facilitator superfamily G3R47_06515 ENOG4105DKK Benzoate G3R47_06520 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase G3R47_06525 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein G3R47_06530 ENOG4108UKV benzoate 1,2-dioxygenase G3R47_06535 ENOG4105FUY alpha subunit G3R47_06540 ENOG4108KB2 LysR family Transcriptional regulator G3R47_06590 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G3R47_06625 ENOG410829K Lysine exporter protein (Lyse ygga) G3R47_06630 ENOG4105VEQ Cold shock protein G3R47_06640 ENOG4105II7 pyrroline-5-carboxylate reductase G3R47_06710 ENOG4105C2X Arabinose 5-phosphate isomerase G3R47_06725 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G3R47_06730 ENOG4108IUZ ABC transporter G3R47_06735 ENOG4105DFG type I secretion outer membrane protein G3R47_06775 ENOG4108Z4U Ferredoxin G3R47_06800 ENOG4105BZU Histidine kinase G3R47_06805 ENOG4105D1S lipid A biosynthesis G3R47_06815 ENOG4105D2S major facilitator superfamily G3R47_06835 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) G3R47_06865 ENOG4108WAV Transcriptional regulator G3R47_06870 ENOG4105C5A transporter G3R47_06890 ENOG4108JIK carboxylase G3R47_06895 ENOG4107R4J Chloride channel G3R47_06910 ENOG4105R8C Transcriptional regulator G3R47_06920 ENOG4105E2A Dehydrogenase G3R47_06935 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3R47_06940 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF G3R47_06960 ENOG4105MRR Transcriptional regulator (By similarity) G3R47_06970 ENOG4108HW3 (ABC) transporter G3R47_07100 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3R47_07130 ENOG4105EMY transcriptional regulator G3R47_07140 ENOG4107Y2X deaminase G3R47_07145 ENOG4105DJ2 Major Facilitator Superfamily G3R47_07170 ENOG4108Z4X TRANSCRIPTIONal G3R47_07180 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3R47_07200 ENOG4105MWK D-amino acid dehydrogenase, small subunit G3R47_07225 ENOG4105CZJ Aldehyde dehydrogenase G3R47_07230 ENOG4107QTZ amino acid G3R47_07235 ENOG4105EJQ L-serine dehydratase G3R47_07240 ENOG4105DXM phenylacetic acid degradation protein G3R47_07245 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit G3R47_07250 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit G3R47_07255 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit G3R47_07260 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit G3R47_07265 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G3R47_07270 ENOG4105E39 Enoyl-CoA hydratase G3R47_07275 ENOG4108UKI Enoyl-CoA hydratase G3R47_07280 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3R47_07285 ENOG4105CHU acetyl-coa acetyltransferase G3R47_07290 ENOG4105DZS Phenylacetate-CoA ligase G3R47_07295 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein G3R47_07300 ENOG4108Z0R Transferase G3R47_07305 ENOG4107YAU phenylacetic acid degradation protein G3R47_07315 ENOG4108TGR phosphatase G3R47_07360 ENOG4105VEQ Cold shock protein G3R47_07375 ENOG4105CF7 AraC family transcriptional regulator G3R47_07390 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G3R47_07395 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G3R47_07400 ENOG4105CSP Major Facilitator Superfamily G3R47_07405 ENOG4107VGR Catalase G3R47_07410 ENOG4105CPW cytochrome b561 G3R47_07415 ENOG4105HEI LysR family (Transcriptional regulator G3R47_07425 ENOG4107HP6 Transcriptional regulator G3R47_07430 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase G3R47_07445 ENOG4105C4Y ABC transporter G3R47_07450 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G3R47_07455 ENOG4107RCV ABC transporter, permease G3R47_07465 ENOG4107STF Involved in phosphonate degradation (By similarity) G3R47_07470 ENOG4108KAZ Involved in phosphonate degradation (By similarity) G3R47_07475 ENOG4107RGD Major Facilitator superfamily G3R47_07480 ENOG4105C1G acyl-Coa dehydrogenase G3R47_07495 ENOG4108UKI Enoyl-CoA hydratase G3R47_07500 ENOG4105EA8 2-Nitropropane dioxygenase G3R47_07505 ENOG4105EQ0 Major Facilitator superfamily G3R47_07515 ENOG4105CHU acetyl-coa acetyltransferase G3R47_07520 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G3R47_07525 ENOG4108R85 Short chain dehydrogenase G3R47_07530 ENOG4105E39 Enoyl-CoA hydratase G3R47_07535 ENOG4105C1G acyl-Coa dehydrogenase G3R47_07540 ENOG4107RGD Major Facilitator superfamily G3R47_07545 ENOG4107QP7 CoA-transferase subunit A G3R47_07550 ENOG4107QNJ CoA-transferase subunit B G3R47_07570 ENOG4105CSU acyl-Coa dehydrogenase G3R47_07585 ENOG4105CC0 LysR family Transcriptional regulator G3R47_07600 ENOG4105E39 Enoyl-CoA hydratase G3R47_07605 ENOG4107QX3 carboxylase G3R47_07610 ENOG4105C1G acyl-Coa dehydrogenase G3R47_07615 ENOG4105R8C Transcriptional regulator G3R47_07620 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_07640 ENOG4105HEI LysR family (Transcriptional regulator G3R47_07685 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G3R47_07705 ENOG4105KT5 UmuD protein G3R47_07715 ENOG4105EW9 transcriptional regulator AsnC family G3R47_07725 ENOG4105BZU Histidine kinase G3R47_07730 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase G3R47_07745 ENOG4105EAD ABC transporter G3R47_07750 ENOG4108HW4 amino acid AbC transporter G3R47_07755 ENOG4105CDA abc transporter atp-binding protein G3R47_07760 ENOG4107RP9 extracellular solute-binding protein, family 3 G3R47_07765 ENOG4105CT1 (ABC) transporter G3R47_07770 ENOG4105EXG Transcriptional regulator G3R47_07775 ENOG4105CCF Lysine exporter protein (Lyse ygga) G3R47_07780 ENOG4105C9B Cysteine desulfurase G3R47_07785 ENOG4105ESN nucleotide-binding protein G3R47_07790 ENOG4105D7W serine acetyltransferase G3R47_07800 ENOG4105CHR reductase G3R47_07805 ENOG4105CBN LysR family transcriptional regulator G3R47_07810 ENOG4105CYM Glutathione S-transferase G3R47_07815 ENOG4108SHQ Glutathione S-transferase G3R47_07820 ENOG4105CMU LysR family (Transcriptional regulator G3R47_07825 ENOG4105VAW lrga family G3R47_07830 ENOG41067MG lrgb family G3R47_07835 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_07850 ENOG4105DXI Major Facilitator superfamily G3R47_07860 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase G3R47_07865 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) G3R47_07880 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase G3R47_07885 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G3R47_07900 ENOG4108K70 Transcriptional regulator G3R47_07905 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_07915 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G3R47_07920 ENOG4105C4M (Ubiquinol oxidase) subunit I G3R47_07940 ENOG4105C54 Major Facilitator superfamily G3R47_07950 ENOG4106FTQ Taurine ABC transporter, periplasmic G3R47_07955 ENOG4108IY8 ABC, transporter G3R47_07960 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G3R47_07975 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G3R47_07985 ENOG4105CBN LysR family transcriptional regulator G3R47_07995 ENOG4105CPN adenine deaminase G3R47_08010 ENOG41082YX Transcriptional regulator, arsr family G3R47_08015 ENOG4105D6J arsenicaL-resistance protein G3R47_08020 ENOG4108KB2 LysR family Transcriptional regulator G3R47_08035 ENOG4108JU3 Alkyl hydroperoxide reductase G3R47_08060 ENOG4105C0B DNA polymerase III (alpha subunit) G3R47_08075 ENOG4105CHM Aminotransferase G3R47_08085 ENOG4108V06 Glutathione peroxidase G3R47_08090 ENOG4105E7U AraC family transcriptional regulator G3R47_08120 ENOG4105ZED uncharacterized protein ygaH G3R47_08125 ENOG4108UMN azlc family G3R47_08150 ENOG4105C3G gtp-binding protein G3R47_08155 ENOG4108UMI ABC transporter, permease G3R47_08160 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G3R47_08165 ENOG4105D01 (LipO)protein G3R47_08170 ENOG4105D01 (LipO)protein G3R47_08185 ENOG4107T8P acyl-Coa dehydrogenase G3R47_08200 ENOG4105EAD ABC transporter G3R47_08205 ENOG4105DRP amino acid AbC transporter G3R47_08210 ENOG4105CDA abc transporter atp-binding protein G3R47_08220 ENOG4105EW9 transcriptional regulator AsnC family G3R47_08235 ENOG41067SE Tetr family transcriptional regulator G3R47_08275 ENOG4105D5G Transposase G3R47_08295 ENOG4105CC0 LysR family Transcriptional regulator G3R47_08305 ENOG4105ETS cytosine purines uracil thiamine allantoin G3R47_08315 ENOG4108IPJ Membrane G3R47_08340 ENOG4105GQR Chaperone G3R47_08345 ENOG4105X0I Fimbrial G3R47_08365 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G3R47_08370 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G3R47_08390 ENOG4108HWY Beta-lactamase G3R47_08415 ENOG4105CV1 Transketolase (EC 2.2.1.1) G3R47_08425 ENOG4108YYC ycei family G3R47_08435 ENOG4108T58 Mg2 transport protein CorA G3R47_08450 ENOG4105YGK Pfam:UPF0157 G3R47_08455 ENOG4105C26 Dehydrogenase G3R47_08460 ENOG4105EW9 transcriptional regulator AsnC family G3R47_08465 ENOG4105CK7 Sodium proline symporter G3R47_08470 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G3R47_08480 ENOG4108ZX5 transcriptional regulator G3R47_08490 ENOG4105BZ1 (ABC) transporter G3R47_08495 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme G3R47_08500 ENOG4105XPP Protein of unknown function (DUF1275) G3R47_08510 ENOG41080HT Transcriptional regulator, arsr family G3R47_08520 ENOG4105EZE Cupin 4 family protein G3R47_08525 ENOG4108UHJ MAF-like protein G3R47_08545 ENOG4105D2N Aldolase G3R47_08550 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G3R47_08555 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) G3R47_08560 ENOG4105EHM Aminoglycoside phosphotransferase G3R47_08565 ENOG4108S0S Nucleotidyl transferase G3R47_08575 ENOG4107QJE Chromosome Partitioning Protein G3R47_08580 ENOG4105FA0 parb-like partition protein G3R47_08595 ENOG4105BZ1 (ABC) transporter G3R47_08600 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) G3R47_08610 ENOG4107QRG dna polymerase iii G3R47_08620 ENOG4105F8V Hydrolase, tatD family G3R47_08645 ENOG4108RTD type II secretion system protein K G3R47_08665 ENOG4108Z6B deaminase G3R47_08680 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G3R47_08685 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) G3R47_08705 ENOG4107RN6 Monooxygenase G3R47_08715 ENOG4105D6Z AFG1 family ATPase G3R47_08720 ENOG4107QP3 malate synthase g G3R47_08730 ENOG4105SG9 biopolymer transport protein, ExbD G3R47_08760 ENOG4105DIB Oligopeptide-binding protein G3R47_08770 ENOG4105DGW oligopeptidase A G3R47_08780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G3R47_08800 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase G3R47_08815 ENOG4105K4T epimerase G3R47_08820 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) G3R47_08840 ENOG4108JA2 transcriptioN-repair coupling factor G3R47_08850 ENOG4105F8J Adenylate Guanylate cyclase G3R47_08855 ENOG4108ZIT Ferredoxin, 2FE-2S G3R47_08870 ENOG4108Z4V iron-sulfur cluster assembly G3R47_08875 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G3R47_08885 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family G3R47_08900 ENOG4105K70 DNA-binding protein G3R47_08905 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G3R47_08910 ENOG4105E7U AraC family transcriptional regulator G3R47_08915 ENOG4105EEF Alkane 1-monooxygenase G3R47_08920 ENOG4105C1G acyl-Coa dehydrogenase G3R47_08925 ENOG4105C1G acyl-Coa dehydrogenase G3R47_08940 ENOG4108Z66 YbaK ebsC protein G3R47_08955 ENOG4105C0R drug resistance transporter emrb qaca subfamily G3R47_08960 ENOG4105DUU IucA IucC family protein G3R47_08965 ENOG4105DJU Siderophore biosynthesis protein G3R47_08975 ENOG4105JSC dimethylmenaquinone methyltransferase G3R47_09015 ENOG4108YZT Adenosylcobinamide kinase G3R47_09020 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) G3R47_09025 ENOG4107TB6 phosphoglycerate mutase G3R47_09040 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G3R47_09045 ENOG4107TSN permease G3R47_09065 ENOG4105CNM Receptor G3R47_09070 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3R47_09085 ENOG4105CJ1 ABC, transporter G3R47_09090 ENOG4107QWP ABC-2 type transporter G3R47_09095 ENOG4107QWP ABC-2 type transporter G3R47_09120 ENOG4105K59 histidine triad (HIT) protein G3R47_09150 ENOG4105F2W methyltransferase G3R47_09160 ENOG4105C28 cystathionine G3R47_09175 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G3R47_09220 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G3R47_09225 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) G3R47_09235 ENOG4105BZU Histidine kinase G3R47_09250 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G3R47_09255 ENOG4107R0V Pyruvate dehydrogenase G3R47_09260 ENOG4105CPP Dehydrogenase, E1 component G3R47_09275 ENOG4105CHR reductase G3R47_09285 ENOG4105FFC UPF0187 protein G3R47_09295 ENOG4107S76 domain protein G3R47_09305 ENOG4108VCT Sulfite exporter TauE/SafE G3R47_09320 ENOG4105UEI Transcriptional Regulator AraC Family G3R47_09325 ENOG4105KVH Transcriptional regulator G3R47_09330 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G3R47_09355 ENOG4106FTQ Taurine ABC transporter, periplasmic G3R47_09360 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G3R47_09380 ENOG4105CSH Transporter G3R47_09390 ENOG4108IJ0 Aspartate ammonia-lyase G3R47_09405 ENOG4107YNJ LysR family Transcriptional regulator G3R47_09415 ENOG4105CHU acetyl-coa acetyltransferase G3R47_09420 ENOG4105CRW Short chain fatty acid transporter G3R47_09435 ENOG4108M0I Transcriptional regulator G3R47_09445 ENOG4105CY2 Citrate transporter G3R47_09450 ENOG4105DTD Dehydrogenase G3R47_09455 ENOG4105CF7 AraC family transcriptional regulator G3R47_09460 ENOG4105D2S major facilitator superfamily G3R47_09470 ENOG4105CHR reductase G3R47_09495 ENOG4105F57 Anthranilate dioxygenase reductase G3R47_09500 ENOG4108YS2 small subunit G3R47_09505 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit G3R47_09510 ENOG4105F4R Transcriptional regulator mode G3R47_09515 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G3R47_09520 ENOG4105E0C molybdate abc transporter G3R47_09525 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G3R47_09530 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G3R47_09535 ENOG4105WQI isochorismatase G3R47_09545 ENOG4107T31 5'-nucleotidase G3R47_09580 ENOG4108IGT Dipeptidase G3R47_09600 ENOG4107RZC phospholipase d G3R47_09745 ENOG4105X0I Fimbrial G3R47_09850 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G3R47_09870 ENOG4105E0A ABC, transporter G3R47_09875 ENOG4105EHG Permease protein G3R47_09885 ENOG4105DQ4 alcohol dehydrogenase G3R47_09890 ENOG4105CF7 AraC family transcriptional regulator G3R47_09895 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G3R47_09905 ENOG4105EXW epimerase dehydratase G3R47_09910 ENOG4105DDW LysR family Transcriptional regulator G3R47_09925 ENOG4105CZJ Aldehyde dehydrogenase G3R47_09945 ENOG4106P55 Transcriptional regulator G3R47_10005 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_10015 ENOG4105CSU acyl-Coa dehydrogenase G3R47_10025 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr G3R47_10030 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3R47_10035 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G3R47_10040 ENOG4108PTX LysR family Transcriptional regulator G3R47_10045 ENOG4107Z3H Transcriptional regulator, TetR family G3R47_10100 ENOG4105CZJ Aldehyde dehydrogenase G3R47_10120 ENOG4107EJG GntR family transcriptional regulator G3R47_10130 ENOG4108KB2 LysR family Transcriptional regulator G3R47_10135 ENOG4105DTQ mandelate racemase muconate lactonizing G3R47_10140 ENOG4105NN7 muconolactone delta-isomerase G3R47_10150 ENOG4107QP7 CoA-transferase subunit A G3R47_10155 ENOG4107QNJ CoA-transferase subunit B G3R47_10160 ENOG4105CHU acetyl-coa acetyltransferase G3R47_10165 ENOG4105F2Z 3-oxoadipate enol-lactonase G3R47_10175 ENOG4105C26 Dehydrogenase G3R47_10185 ENOG4105F11 amine oxidase G3R47_10205 ENOG4105CHR reductase G3R47_10215 ENOG4105FUY alpha subunit G3R47_10235 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G3R47_10245 ENOG4105DNH Major Facilitator G3R47_10270 ENOG4105C1G acyl-Coa dehydrogenase G3R47_10275 ENOG4108PTX LysR family Transcriptional regulator G3R47_10280 ENOG4107HP6 Transcriptional regulator G3R47_10295 ENOG4105MD1 YeeE YedE family protein G3R47_10305 ENOG4105DZG Dehydrogenase G3R47_10310 ENOG4105TW1 Carbohydrate-selective porin OprB G3R47_10315 ENOG4106JPM 3-dehydroshikimate dehydratase G3R47_10320 ENOG4105FF2 Type I DHQase G3R47_10325 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha G3R47_10330 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta G3R47_10335 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase G3R47_10340 ENOG4105D2S major facilitator superfamily G3R47_10345 ENOG4105F2Z 3-oxoadipate enol-lactonase G3R47_10350 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase G3R47_10355 ENOG4105CHU acetyl-coa acetyltransferase G3R47_10360 ENOG4107QNJ CoA-transferase subunit B G3R47_10365 ENOG4107QP7 CoA-transferase subunit A G3R47_10375 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G3R47_10380 ENOG4107VMU Membrane G3R47_10425 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3R47_10440 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G3R47_10450 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G3R47_10455 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) G3R47_10485 ENOG4105C7B Threonine dehydratase G3R47_10495 ENOG4105CZN Potassium uptake protein G3R47_10500 ENOG4105HDD phospholipase G3R47_10510 ENOG4105E0K tonB-dependent siderophore receptor G3R47_10525 ENOG4105PV3 Inner membrane protein yqiJ G3R47_10535 ENOG4105C4M (Ubiquinol oxidase) subunit I G3R47_10540 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G3R47_10560 ENOG41068P6 UPF0319 protein G3R47_10570 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G3R47_10595 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3R47_10600 ENOG4105C8Y Acetylornithine aminotransferase G3R47_10605 ENOG4105M2J Glutaredoxin G3R47_10615 ENOG4105CC0 LysR family Transcriptional regulator G3R47_10620 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G3R47_10625 ENOG4105CWM branched-chain amino acid transport system II carrier protein G3R47_10650 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G3R47_10655 ENOG4105DE4 1-phosphofructokinase G3R47_10660 ENOG4105DM4 PTS System G3R47_10675 ENOG4105BZU Histidine kinase G3R47_10685 ENOG4105D8V Glucose sorbosone dehydrogenase G3R47_10690 ENOG4108RAV Conserved protein G3R47_10695 ENOG4105CHH sulfate transporter G3R47_10710 ENOG4105C85 amino acid G3R47_10720 ENOG4105F7P transcriptional regulator AsnC family G3R47_10745 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 G3R47_10750 ENOG4105VEJ Heat shock protein G3R47_10760 ENOG4105Y3E Modulates RecA activity (By similarity) G3R47_10775 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G3R47_10795 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G3R47_10800 ENOG4105DZP Membrane-associated zinc metalloprotease G3R47_10810 ENOG4105KNE Phosphatidate cytidylyltransferase G3R47_10815 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G3R47_10840 ENOG4105CUX Signal transduction histidine kinase G3R47_10845 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G3R47_10900 ENOG4105CMR udp-glucose 4-epimerase G3R47_10905 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) G3R47_10925 ENOG4105T38 integral membrane protein G3R47_10930 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_10940 ENOG4105CVM Molybdenum cofactor synthesis domain protein G3R47_10945 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G3R47_10980 ENOG4108IFG nitrite reductase, (NAD(P)H) G3R47_10985 ENOG4107QZF nitrite reductase NADPH large subunit G3R47_10995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3R47_11020 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G3R47_11025 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G3R47_11035 ENOG4105D8G Major Facilitator superfamily G3R47_11040 ENOG4105VZ8 Transcriptional regulator G3R47_11100 ENOG4105DR5 peptidase G3R47_11355 ENOG4105CBC glutamate synthase G3R47_11395 ENOG4105C0A alcohol dehydrogenase G3R47_11405 ENOG4105HSS phospholipase C G3R47_11410 ENOG4107QMP dna polymerase iii subunits gamma and tau G3R47_11445 ENOG4105CHR reductase G3R47_11450 ENOG4105CHU acetyl-coa acetyltransferase G3R47_11460 ENOG4105CC0 LysR family Transcriptional regulator G3R47_11470 ENOG4108NIW Leucine export protein LeuE G3R47_11475 ENOG4105EW9 transcriptional regulator AsnC family G3R47_11480 ENOG4105DKK Benzoate G3R47_11515 ENOG41081QV Universal stress protein G3R47_11520 ENOG4105C5H ABC transporter G3R47_11540 ENOG4105CNM Receptor G3R47_11570 ENOG4105CUY Mechanosensitive ion channel G3R47_11580 ENOG4105R8C Transcriptional regulator G3R47_11590 ENOG4105EW9 transcriptional regulator AsnC family G3R47_11630 ENOG4105CD8 aminopeptidase N G3R47_11655 ENOG4107QUV Domain protein G3R47_11660 ENOG4105C0A alcohol dehydrogenase G3R47_11670 ENOG4107RR1 TRANSCRIPTIONal G3R47_11680 ENOG4107R55 ethanolamine transporter G3R47_11685 ENOG4105CPD ethanolamine ammonia-lyase G3R47_11690 ENOG4107FQ9 ethanolamine ammonia-lyase G3R47_11695 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) G3R47_11700 ENOG4105CX6 glutaminyL-tRNA synthetase G3R47_11710 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) G3R47_11720 ENOG4108RCM Nitroreductase G3R47_11725 ENOG4108TZV Membrane G3R47_11730 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) G3R47_11740 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G3R47_11745 ENOG4105K8N protein family UPF0079, ATPase G3R47_11780 ENOG4105DZ2 Transcriptional regulator G3R47_11800 ENOG4105F27 Major Facilitator G3R47_11805 ENOG4105EYW Ion transport protein G3R47_11815 ENOG4107QIJ Aconitate hydratase 2 G3R47_11830 ENOG4105CFU surface antigen G3R47_11835 ENOG4107S74 Lysophospholipid transporter LplT G3R47_11850 ENOG4105CFQ glutamine synthetase G3R47_11855 ENOG4105EEX Two component transcriptional regulator (Winged helix family G3R47_11860 ENOG4105C08 Histidine kinase G3R47_11865 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G3R47_11870 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3R47_11875 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G3R47_11895 ENOG4105D06 uba thif-type nad fad binding protein G3R47_11900 ENOG4108MEJ flavin reductase domain protein G3R47_11910 ENOG4105C1G acyl-Coa dehydrogenase G3R47_11925 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G3R47_11940 ENOG4105CC0 LysR family Transcriptional regulator G3R47_11955 ENOG4105DEN Luciferase family G3R47_11970 ENOG4105CND Glycosyl transferase, family 2 G3R47_11975 ENOG4107BJW polysaccharide deacetylase G3R47_12000 ENOG4105E2S oxidase) subunit II G3R47_12005 ENOG4105BZ9 Cytochrome C oxidase, subunit I G3R47_12010 ENOG4105CCU oxidase (Subunit III) G3R47_12015 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) G3R47_12040 ENOG4105CDU Replicative dna helicase G3R47_12045 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G3R47_12095 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) G3R47_12100 ENOG4105DC1 bifunctional purine biosynthesis protein purh G3R47_12105 ENOG4105C12 Phosphoribosylglycinamide synthetase G3R47_12115 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G3R47_12120 ENOG4108UMI ABC transporter, permease G3R47_12125 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G3R47_12135 ENOG4105CK2 sodium dicarboxylate symporter G3R47_12185 ENOG4105ETX regulatoR G3R47_12190 ENOG4105DHQ Histidine kinase G3R47_12195 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G3R47_12205 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G3R47_12245 ENOG4105VT2 5-hydroxyisourate hydrolase G3R47_12255 ENOG4105DY2 Paraquat-inducible protein b G3R47_12260 ENOG4105F1S paraquat-inducible protein a G3R47_12285 ENOG4105CSH Transporter G3R47_12335 ENOG4105JXH GntR family transcriptional regulator G3R47_12345 ENOG4105D6U Sodium Glutamate Symporter G3R47_12375 ENOG4105H4F exported protein G3R47_12410 ENOG4105C26 Dehydrogenase G3R47_12415 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G3R47_12420 ENOG4105EVZ LysR family transcriptional regulator G3R47_12445 ENOG4105D9P serine threonine protein kinase G3R47_12475 ENOG4105KTH gatB Yqey G3R47_12480 ENOG4105ERG peptidase m48, ste24p G3R47_12485 ENOG4105C5I Dehydrogenase G3R47_12500 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G3R47_12535 ENOG41069NU Nitroreductase G3R47_12545 ENOG4105C1J atp-dependent rna helicase G3R47_12550 ENOG4105VEQ Cold shock protein G3R47_12560 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3R47_12565 ENOG4105M08 Membrane G3R47_12595 ENOG4105CYB regulatoR G3R47_12600 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G3R47_12605 ENOG4105E0Y RtcB Protein G3R47_12625 ENOG4105CIN aminoacyl-histidine dipeptidase G3R47_12635 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G3R47_12640 ENOG4105CQC Prephenate dehydratase G3R47_12655 ENOG4105CK2 sodium dicarboxylate symporter G3R47_12660 ENOG4107QYG anthranilate phosphoribosyltransferase G3R47_12665 ENOG4105VUT cytoplasmic protein G3R47_12670 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G3R47_12675 ENOG4105BZ4 penicillin-binding protein G3R47_12685 ENOG4105M6F mutator MutT protein G3R47_12695 ENOG4105DHQ Histidine kinase G3R47_12700 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3R47_12710 ENOG4107QHF type ii secretion system protein e G3R47_12720 ENOG4108R96 Methyltransferase, YaeB family G3R47_12725 ENOG4105DP0 ferredoxin-NADP reductase G3R47_12730 ENOG4105JAB phenazine biosynthesis protein, phzf family G3R47_12735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G3R47_12740 ENOG4105CFP Peptidase U32 G3R47_12745 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G3R47_12755 ENOG4108JEH abc transporter atp-binding protein G3R47_12760 ENOG4106YG3 ABC transporter G3R47_12765 ENOG4105DSP amino acid AbC transporter G3R47_12770 ENOG4105E89 ABC transporter G3R47_12780 ENOG4105ENT Efflux transporter rnd family, mfp subunit G3R47_12790 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3R47_12825 ENOG4105DA5 (ABC) transporter G3R47_12830 ENOG4105E3A (ABC) transporter G3R47_12845 ENOG4105CNI cell division protein FtsW G3R47_12850 ENOG4105CVE Lytic murein transglycosylase G3R47_12890 ENOG4105CE9 30S ribosomal protein S2 G3R47_12895 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G3R47_12905 ENOG4107RNU major facilitator superfamily MFS_1 G3R47_12915 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) G3R47_12920 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G3R47_12925 ENOG4107QPN acyl-Coa dehydrogenase G3R47_12940 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) G3R47_12945 ENOG4105SYT Methylenetetrahydrofolate reductase G3R47_12950 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G3R47_12955 ENOG4105BZU Histidine kinase G3R47_12965 ENOG4105C6K Malic enzyme G3R47_12975 ENOG4105C0H protease G3R47_12980 ENOG4107QNR UPF0135 protein G3R47_12985 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G3R47_13025 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) G3R47_13040 ENOG4105DUX Transporter G3R47_13050 ENOG4105DDQ anthranilate synthase G3R47_13055 ENOG4105CD8 aminopeptidase N G3R47_13085 ENOG4105C7W Xanthine dehydrogenase G3R47_13095 ENOG4105EUJ GTP cyclohydrolase i G3R47_13115 ENOG4105NX3 Membrane G3R47_13130 ENOG4105E4F Isochorismate synthase G3R47_13145 ENOG4108JJ7 ABC transporter G3R47_13150 ENOG4105BZ1 (ABC) transporter G3R47_13165 ENOG4105WQI isochorismatase G3R47_13170 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G3R47_13175 ENOG4105C0W non-ribosomal peptide synthetase G3R47_13195 ENOG4108IPW abc transporter atp-binding protein G3R47_13210 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_13225 ENOG4105WWK YheO domain protein G3R47_13235 ENOG4105C2I pirin domain protein G3R47_13270 ENOG4105VCD cytoplasmic protein G3R47_13275 ENOG4105D22 carbon starvation protein G3R47_13285 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G3R47_13295 ENOG41066DG (EAL) domain protein G3R47_13305 ENOG4105DHU Bile acid G3R47_13320 ENOG4105DAN ATP-dependent protease G3R47_13325 ENOG4105EJC lysr family transcriptional regulator G3R47_13330 ENOG4108K5P (LipO)protein G3R47_13350 ENOG4105DZ1 carboxypeptidase G3R47_13355 ENOG4108Z0R Transferase G3R47_13375 ENOG4107QTF adenylosuccinate lyase G3R47_13390 ENOG4105ERU peptidase G3R47_13395 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G3R47_13405 ENOG4105C8U phosphate abc transporter G3R47_13410 ENOG4105CVA phosphate G3R47_13415 ENOG4105C85 amino acid G3R47_13420 ENOG4107RA9 decarboxylase G3R47_13425 ENOG4105F7P transcriptional regulator AsnC family G3R47_13435 ENOG4105DY8 decarboxylase G3R47_13440 ENOG4108JPW Aminotransferase G3R47_13465 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G3R47_13480 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) G3R47_13485 ENOG4105D3G Pseudouridine synthase G3R47_13500 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G3R47_13530 ENOG4105JAB phenazine biosynthesis protein, phzf family G3R47_13535 ENOG4108ETY sodium dicarboxylate symporter G3R47_13540 ENOG4105EGI Transcriptional regulator G3R47_13545 ENOG4105CBP Major Facilitator G3R47_13570 ENOG4108R99 pseudouridine synthase G3R47_13575 ENOG4105E9K Isocitrate dehydrogenase G3R47_13585 ENOG4105DZ1 carboxypeptidase G3R47_13590 ENOG4105CEP NADH dehydrogenase G3R47_13595 ENOG4108YZY peptidylprolyl cis-trans isomerase G3R47_13600 ENOG4105CVP deoxyribo-dipyrimidine photolyase G3R47_13615 ENOG4107R8N Glycosyl transferase, family 2 G3R47_13645 ENOG4105EA8 2-Nitropropane dioxygenase G3R47_13650 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G3R47_13655 ENOG4107QS8 (LipO)protein G3R47_13690 ENOG4105DTR rard protein G3R47_13700 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G3R47_13710 ENOG4105BZU Histidine kinase G3R47_13730 ENOG4105F7F Chaperone G3R47_13760 ENOG4105EMU Dehydrogenase G3R47_13765 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase G3R47_13770 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G3R47_13775 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) G3R47_13785 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G3R47_13800 ENOG4105C3F Signal peptidase i G3R47_13815 ENOG4105C0H protease G3R47_13820 ENOG4108IYU L-aspartate oxidase G3R47_13835 ENOG4105HHA aminodeoxychorismate lyase G3R47_13840 ENOG4105YAZ 4-amino-4-deoxychorismate lyase G3R47_13845 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G3R47_13855 ENOG4108I5D sulfate abc transporter G3R47_13865 ENOG4108IJ6 ABC transporter G3R47_13870 ENOG4107R11 Transcriptional regulator G3R47_13885 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G3R47_13890 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G3R47_13905 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G3R47_13920 ENOG4108UKI Enoyl-CoA hydratase G3R47_13930 ENOG4105C2C drug resistance transporter, Bcr CflA G3R47_13935 ENOG4108ETH Formylglycinamide ribotide synthetase G3R47_13955 ENOG4105CH2 amidohydrolase G3R47_13960 ENOG4107YD3 Thioesterase G3R47_13965 ENOG4105E02 MotA TolQ exbB proton channel G3R47_13970 ENOG4105M8F Biopolymer transport protein exbD tolR G3R47_13980 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) G3R47_13985 ENOG4105KCK Peptidoglycan-associated lipoprotein G3R47_14035 ENOG4105C02 permease G3R47_14045 ENOG4108V3E phosphoribosylglycinamide formyltransferase G3R47_14050 ENOG4107R6F Alpha Beta Hydrolase Fold protein G3R47_14055 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G3R47_14065 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 G3R47_14070 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G3R47_14075 ENOG4105D60 lipoprotein releasing system transmembrane protein G3R47_14105 ENOG4107KET secretion protein, HlyD family G3R47_14140 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3R47_14145 ENOG4105C10 Electron transfer flavoprotein G3R47_14150 ENOG4105BZJ Electron transfer flavoprotein G3R47_14155 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G3R47_14160 ENOG4105N14 lysine exporter protein LysE YggA G3R47_14165 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G3R47_14175 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G3R47_14185 ENOG4105C85 amino acid G3R47_14190 ENOG4105BZG amino acid carrier protein G3R47_14195 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G3R47_14205 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) G3R47_14220 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G3R47_14225 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit G3R47_14230 ENOG4105BZW Glycerate kinase G3R47_14270 ENOG4105CEY Amp-dependent synthetase and ligase G3R47_14285 ENOG4108RRZ Transcription elongation factor GreB G3R47_14305 ENOG4105E4C Lytic transglycosylase catalytic G3R47_14320 ENOG4105BZS acriflavin resistance protein G3R47_14325 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G3R47_14335 ENOG41080IJ Diacylglycerol kinase G3R47_14350 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G3R47_14365 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G3R47_14370 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G3R47_14375 ENOG4105CSH Transporter G3R47_14425 ENOG4105EEI dihydropteroate synthase G3R47_14430 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G3R47_14440 ENOG4105HBR Rna-binding protein G3R47_14455 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G3R47_14460 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G3R47_14470 ENOG4108IG5 Transcriptional regulator G3R47_14475 ENOG4108UQ8 endoribonuclease L-psp G3R47_14485 ENOG41080TK Universal stress protein G3R47_14500 ENOG4105PNM synthesis protein G3R47_14515 ENOG4105EEQ Na H antiporter G3R47_14520 ENOG4105CGZ zinc metallopeptidase G3R47_14525 ENOG4105CKW Inner membrane protein yedI G3R47_14535 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G3R47_14545 ENOG4107QN2 dihydrolipoyl dehydrogenase G3R47_14550 ENOG4105C7S Dehydrogenase G3R47_14555 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G3R47_14570 ENOG4105E33 succinate dehydrogenase G3R47_14580 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein G3R47_14585 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit G3R47_14615 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G3R47_14620 ENOG41084BA UPF0250 protein G3R47_14625 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) G3R47_14640 ENOG4105CUB amino acid G3R47_14655 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G3R47_14660 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G3R47_14675 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) G3R47_14700 ENOG410841Q phosphoesterase PA-phosphatase related protein G3R47_14705 ENOG4105C1P efflux transporter, rnd family, mfp subunit G3R47_14710 ENOG4105BZS acriflavin resistance protein G3R47_14715 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G3R47_14720 ENOG4105K8R UPF0145 protein G3R47_14725 ENOG4105K8R UPF0145 protein G3R47_14745 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G3R47_14750 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) G3R47_14775 ENOG4108M0I Transcriptional regulator G3R47_14790 ENOG4105DHQ Histidine kinase G3R47_14795 ENOG4105XJC Two component transcriptional regulator (Winged helix family G3R47_14800 ENOG4105DIJ Phosphoethanolamine transferase G3R47_14820 ENOG4105D78 K07001 NTE family protein G3R47_14835 ENOG4105MSB protein, conserved in bacteria G3R47_14840 ENOG4105CTB Polyprenyl synthetase G3R47_14845 ENOG4105C7F AcnD-accessory protein PrpF G3R47_14850 ENOG4105C85 amino acid G3R47_14890 ENOG4105CF7 AraC family transcriptional regulator G3R47_14915 ENOG4108X0B nad(p)h dehydrogenase (quinone) G3R47_14925 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein G3R47_14935 ENOG4105D8T Acyltransferase G3R47_14945 ENOG4105C03 ribonuclease G3R47_14950 ENOG4108Z03 MAF-like protein G3R47_14955 ENOG4105VQ7 Rod shape-determining protein MreD G3R47_14960 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) G3R47_14970 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3R47_14980 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G3R47_15005 ENOG4105C9K Endothelin-converting enzyme 1 G3R47_15015 ENOG4105C7B Threonine dehydratase G3R47_15020 ENOG4105D78 K07001 NTE family protein G3R47_15025 ENOG4105BZG amino acid carrier protein G3R47_15045 ENOG4105C2C drug resistance transporter, Bcr CflA G3R47_15050 ENOG4105EM2 membrane G3R47_15100 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G3R47_15105 ENOG4105WD1 Membrane G3R47_15115 ENOG4107PEH Entericidin EcnA/B family G3R47_15130 ENOG4105CBS Chea signal transduction histidine kinase G3R47_15135 ENOG4105C8Q Methyl-accepting chemotaxis G3R47_15140 ENOG4108ZGA chew protein G3R47_15145 ENOG4105M3Z response regulator G3R47_15150 ENOG4108UNF response regulator G3R47_15175 ENOG4105KWI UPF0339 protein G3R47_15180 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA G3R47_15185 ENOG4105K78 MarR family Transcriptional regulator G3R47_15195 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G3R47_15200 ENOG4105T95 Thiol disulfide interChange protein G3R47_15210 ENOG4108N2Y auxin Efflux G3R47_15215 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3R47_15220 ENOG4105CHB tonB-dependent Receptor G3R47_15225 ENOG4108VX5 3-methyladenine DNA glycosylase G3R47_15235 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G3R47_15250 ENOG4105CI3 gtp-binding protein typa G3R47_15255 ENOG4105C2W permease G3R47_15265 ENOG4108IQI permease G3R47_15270 ENOG4105E0Y RtcB Protein G3R47_15280 ENOG4108WHA ompa motb domain protein G3R47_15290 ENOG4105CHU acetyl-coa acetyltransferase G3R47_15310 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G3R47_15315 ENOG4105DZG Dehydrogenase G3R47_15320 ENOG4105TW1 Carbohydrate-selective porin OprB G3R47_15330 ENOG4108R6W Transcriptional regulator, ARAC family G3R47_15335 ENOG4105CHU acetyl-coa acetyltransferase G3R47_15365 ENOG4108UT2 hemolysin iii G3R47_15370 ENOG4105CSH Transporter G3R47_15385 ENOG4105D3R alkyl hydroperoxide reductase G3R47_15405 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G3R47_15450 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G3R47_15455 ENOG4108WBT adenosyltransferase G3R47_15475 ENOG4105CNG UPF0061 protein G3R47_15480 ENOG4105E3W Two component transcriptional regulator (Winged helix family G3R47_15485 ENOG4105EB3 Histidine kinase G3R47_15495 ENOG4105CSU acyl-Coa dehydrogenase G3R47_15500 ENOG4105CSU acyl-Coa dehydrogenase G3R47_15505 ENOG4108VY7 phosphate-starvation-inducible protein PsiE G3R47_15525 ENOG4105UGU tonB-dependent Receptor G3R47_15550 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G3R47_15565 ENOG4108PQP glycosyl transferase group 1 G3R47_15575 ENOG4107BJW polysaccharide deacetylase G3R47_15590 ENOG4105CM2 brancheD-chain amino acid aminotransferase G3R47_15595 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G3R47_15600 ENOG4105BZU Histidine kinase G3R47_15635 ENOG4105VIE preprotein translocase, subunit YajC G3R47_15640 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3R47_15645 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G3R47_15650 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G3R47_15660 ENOG4105FFC UPF0187 protein G3R47_15665 ENOG4105DB7 PHP domain protein G3R47_15675 ENOG4105K9H YciI-like protein G3R47_15705 ENOG4105NAU thioesterase Superfamily protein G3R47_15715 ENOG4107U2T alpha beta G3R47_15730 ENOG4107QN2 dihydrolipoyl dehydrogenase G3R47_15770 ENOG4108KHX Diguanylate cyclase G3R47_15775 ENOG4105UYK outer membrane protein a G3R47_15785 ENOG4107RZC phospholipase d G3R47_15795 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G3R47_15815 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) G3R47_15820 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G3R47_15825 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G3R47_15835 ENOG4108UJD 30S ribosomal protein S9 G3R47_15840 ENOG4107MKT Stringent starvation protein a G3R47_15845 ENOG4105KB2 stringent starvation protein b G3R47_15865 ENOG4105C1G acyl-Coa dehydrogenase G3R47_15870 ENOG4107QX3 carboxylase G3R47_15885 ENOG4108RZE Tetr family transcriptional regulator G3R47_15890 ENOG4105C1G acyl-Coa dehydrogenase G3R47_15940 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G3R47_15945 ENOG4105D6S protein involved in catabolism of external DNA G3R47_15975 ENOG4105E4C Lytic transglycosylase catalytic G3R47_15985 ENOG4105C9A Phoh family G3R47_16015 ENOG4105CS1 NAD(P)H quinone oxidoreductase G3R47_16020 ENOG4107S2Z UPF0761 membrane protein G3R47_16030 ENOG4108K2B transcriptional regulator G3R47_16035 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G3R47_16080 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G3R47_16085 ENOG4105DGW oligopeptidase A G3R47_16090 ENOG4105VKU nucleicacid-binding protein G3R47_16125 ENOG4105C1G acyl-Coa dehydrogenase G3R47_16165 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G3R47_16275 ENOG41089BK Glutamine amido-transferase G3R47_16285 ENOG4105D7A ATP-binding protein G3R47_16295 ENOG4105KPV Transcriptional regulator G3R47_16310 ENOG4105CK2 sodium dicarboxylate symporter G3R47_16315 ENOG4105C29 acyl-CoA thioesterase G3R47_16335 ENOG4105CB5 ATP-dependent DNA helicase recG G3R47_16340 ENOG4105MJ2 Competence protein G3R47_16350 ENOG4108URH decarboxylase G3R47_16355 ENOG4105D7N magnesium and cobalt transport protein CorA G3R47_16365 ENOG4105E3I toluene tolerance G3R47_16375 ENOG4105CY3 ABC transporter, permease G3R47_16380 ENOG4105DHJ ABC, transporter G3R47_16390 ENOG4105C1J atp-dependent rna helicase G3R47_16395 ENOG4105ECY inositol monophosphatase G3R47_16410 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) G3R47_16425 ENOG4105CSU acyl-Coa dehydrogenase G3R47_16435 ENOG41067S9 phage shock protein C, PspC G3R47_16440 ENOG4105W87 Cbs domain G3R47_16490 ENOG4105D5G Transposase G3R47_16540 ENOG4105C26 Dehydrogenase G3R47_16550 ENOG4105C8Y Acetylornithine aminotransferase G3R47_16555 ENOG4105D82 Glutamate dehydrogenase G3R47_16560 ENOG4108IQI permease G3R47_16590 ENOG4107SKI cobyrinic Acid a,c-diamide synthase G3R47_16595 ENOG4105IPI Membrane G3R47_16600 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G3R47_16605 ENOG4105EM2 membrane G3R47_16610 ENOG4107QF7 multi-drug G3R47_16620 ENOG4105NF4 modulator of drug activity G3R47_16625 ENOG4105VRH Antibiotic biosynthesis monooxygenase G3R47_16635 ENOG4105CQB FAD linked oxidase domain protein G3R47_16640 ENOG4108JQ1 Dehydrogenase G3R47_16665 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G3R47_16670 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) G3R47_16675 ENOG4107IFA Lipase (EC 3.1.1.3) G3R47_16690 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G3R47_16740 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G3R47_16755 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G3R47_16760 ENOG4105KME endoribonuclease L-psp G3R47_16770 ENOG4108UQY Iron-storage protein G3R47_16775 ENOG4108YSG O-Antigen polymerase G3R47_16795 ENOG4105HA9 of methanol dehydrogenase type G3R47_16800 ENOG4108V0P LemA family G3R47_16810 ENOG4105BZ8 glutamate synthase G3R47_16815 ENOG4105CBC glutamate synthase G3R47_16835 ENOG4105E4G Type IV pilus G3R47_16860 ENOG4108JQC penicillin-binding protein 1A G3R47_16865 ENOG4105DHI Methyltransferase G3R47_16880 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G3R47_16885 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G3R47_16890 ENOG4105CJN penicillin-binding protein G3R47_16905 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G3R47_16930 ENOG4108IQI permease G3R47_16995 ENOG4105C5H ABC transporter G3R47_17005 ENOG4105PDP Short chain dehydrogenase G3R47_17010 ENOG4105CHH sulfate transporter G3R47_17025 ENOG4105E0F Histidine kinase G3R47_17035 ENOG4105CYC Transferase G3R47_17040 ENOG4108R6G acetyltransferase G3R47_17065 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G3R47_17085 ENOG4105BZ1 (ABC) transporter G3R47_17100 ENOG41061CK Antibiotic biosynthesis monooxygenase G3R47_17115 ENOG4105CUV Homoserine Kinase G3R47_17170 ENOG4108UQN AraC family transcriptional regulator G3R47_17175 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain G3R47_17190 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G3R47_17195 ENOG4105KVH Transcriptional regulator G3R47_17205 ENOG4105C2J ABC transporter G3R47_17220 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) G3R47_17225 ENOG4105CPC Aldo Keto reductase G3R47_17275 ENOG4106NZI LysR family Transcriptional regulator G3R47_17280 ENOG4105D94 Major Facilitator Superfamily G3R47_17365 ENOG4105D5G Transposase G3R47_17395 ENOG4105EUB pirin domain protein G3R47_17400 ENOG4105CHJ isochorismatase hydrolase G3R47_17410 ENOG4105C26 Dehydrogenase G3R47_17415 ENOG4108JPW Aminotransferase G3R47_17425 ENOG4105C85 amino acid G3R47_17435 ENOG4108UMN azlc family G3R47_17445 ENOG4108UUM single-stranded DNA-binding protein G3R47_17450 ENOG4107RDB Major Facilitator G3R47_17460 ENOG4105DWF phosphomethylpyrimidine kinase G3R47_17465 ENOG4105RA2 Membrane G3R47_17475 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G3R47_17480 ENOG4108WUH Transcriptional regulator, TetR family G3R47_17485 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G3R47_17490 ENOG4105BZU Histidine kinase G3R47_17500 ENOG4105C94 Transporter G3R47_17510 ENOG4107QN1 sodium solute G3R47_17515 ENOG41062QD Membrane G3R47_17520 ENOG4105BZU Histidine kinase G3R47_17535 ENOG4108UZX fmn reductase G3R47_17540 ENOG4105FBW Monooxygenase G3R47_17550 ENOG4108W2Y isochorismatase G3R47_17555 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G3R47_17565 ENOG4105D64 Mechanosensitive ion channel G3R47_17575 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G3R47_17580 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G3R47_17600 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G3R47_17615 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G3R47_17630 ENOG4105E0K tonB-dependent siderophore receptor G3R47_17645 ENOG4107QSN dihydrolipoamide acetyltransferase G3R47_17650 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G3R47_17655 ENOG41063SB peptidase G3R47_17670 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G3R47_17675 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G3R47_17680 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G3R47_17700 ENOG4105D7Z glutathione synthase G3R47_17725 ENOG4105CGK Exodeoxyribonuclease III G3R47_17730 ENOG4105KUZ arsenate reductase G3R47_17745 ENOG4105BZU Histidine kinase G3R47_17750 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) G3R47_17780 ENOG41084YZ Hydrolase G3R47_17795 ENOG41061H0 Monooxygenase G3R47_17805 ENOG4108Z2U ureidoglycolate hydrolase G3R47_17810 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G3R47_17815 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G3R47_17820 ENOG4105IPS esterase G3R47_17880 ENOG4105CS6 Rhs element vgr protein G3R47_17890 ENOG4105D9M gamma-glutamylcysteine synthetase G3R47_17905 ENOG4106BRA Membrane G3R47_17910 ENOG4105CHM Aminotransferase G3R47_17915 ENOG4107QJQ Mate efflux family protein G3R47_17930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3R47_17935 ENOG4105BZU Histidine kinase G3R47_17950 ENOG4105KHC sulfurtransferase G3R47_17985 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G3R47_18000 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G3R47_18005 ENOG4108ZAI phosphatidylglycerophosphatase a G3R47_18015 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G3R47_18020 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G3R47_18035 ENOG41088SP formiminoglutamate hydrolase G3R47_18045 ENOG4105C85 amino acid G3R47_18060 ENOG41090B9 response to stress G3R47_18065 ENOG4105CZE histidine utilization repressor G3R47_18075 ENOG4105CKI cobalamin synthesis protein G3R47_18085 ENOG4105C85 amino acid G3R47_18095 ENOG4108RXX maleylacetoacetate isomerase G3R47_18115 ENOG4105EWC Purine nucleoside phosphorylase G3R47_18120 ENOG4107QI1 Mate efflux family protein G3R47_18125 ENOG4105C09 Bile acid G3R47_18130 ENOG4108RWI nicotinamidase G3R47_18135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G3R47_18155 ENOG4105S64 Formate nitrite transporter G3R47_18160 ENOG4105D1H recombination factor protein RarA G3R47_18170 ENOG4108ZZ3 UPF0260 protein G3R47_18190 ENOG4105CEN a g-specific adenine glycosylase G3R47_18205 ENOG4108R3E Dna-3-methyladenine glycosylase i G3R47_18230 ENOG4105HEI LysR family (Transcriptional regulator G3R47_18235 ENOG4105CV8 reductase G3R47_18240 ENOG4105F27 Major Facilitator G3R47_18275 ENOG4105DJY efflux transporter, rnd family, mfp subunit G3R47_18280 ENOG4108IG5 Transcriptional regulator G3R47_18290 ENOG4105C2W permease G3R47_18295 ENOG4108W5M transcriptional regulator G3R47_18320 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G3R47_18330 ENOG4105C8J )-transporter G3R47_18375 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G3R47_18430 ENOG4105CVE Lytic murein transglycosylase G3R47_18435 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G3R47_18440 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G3R47_18450 ENOG4105DFU Cell wall formation (By similarity) G3R47_18460 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G3R47_18465 ENOG4105DU1 integral membrane protein, terc G3R47_18475 ENOG4106032 Glutathionylspermidine synthase G3R47_18485 ENOG4107QUY Guanine deaminase G3R47_18490 ENOG4108UGV hypoxanthine phosphoribosyltransferase G3R47_18500 ENOG4105T95 Thiol disulfide interChange protein G3R47_18505 ENOG4105PGM cation diffusion facilitator family transporter G3R47_18520 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins G3R47_18540 ENOG4107QHF type ii secretion system protein e G3R47_18560 ENOG4105FA0 parb-like partition protein G3R47_18565 ENOG4107QJE Chromosome Partitioning Protein G3R47_18655 ENOG4105EKQ RNA-directed DNA polymerase G3R47_18665 ENOG4105MP0 transposase G3R47_18685 ENOG4105EKQ RNA-directed DNA polymerase G3R47_18835 ENOG4105ERG peptidase m48, ste24p G3R47_18910 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) G3R47_18940 ENOG4108BUD transposase G3R47_18955 ENOG4105C1P efflux transporter, rnd family, mfp subunit G3R47_18960 ENOG4105BZS acriflavin resistance protein G3R47_18970 ENOG4105BZU Histidine kinase G3R47_18975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G3R47_18985 ENOG4108HWY Beta-lactamase G3R47_19040 ENOG4105I1F Resistance protein G3R47_19065 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G3R47_19195 ENOG4107QMH DNA methylase G3R47_19205 ENOG4105KK6 nuclease G3R47_19255 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) G3R47_19430 ENOG4105F9F transposase G3R47_19450 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) G3R47_19455 ENOG4105VF7 tolerance protein G3R47_19460 ENOG4105EPC oxidoreductase G3R47_19465 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase G3R47_19480 ENOG4105F9F transposase G3R47_19515 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G3R47_19520 ENOG4105KT5 UmuD protein G3R47_19595 ENOG4105DND Transcriptional regulator G3R47_19610 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G3R47_19695 ENOG4105EMU Dehydrogenase