locus-tag	class	description
EP550_00010	COG0592	DNA-directed DNA polymerase activity
EP550_00020	COG0187	DNA topoisomerase II activity
EP550_00030	COG0586	Pfam SNARE associated Golgi protein
EP550_00035	COG0488	(ABC) transporter
EP550_00060	COG0596	Alpha beta hydrolase
EP550_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EP550_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EP550_00115	COG0733	neurotransmitter:sodium symporter activity
EP550_00125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EP550_00150	COG0583	DNA-binding transcription factor activity
EP550_00155	COG2233	PERMEase
EP550_00170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP550_00205	COG2814	Major facilitator Superfamily
EP550_00210	COG0656	L-ascorbic acid biosynthetic process
EP550_00215	COG0583	DNA-binding transcription factor activity
EP550_00230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP550_00235	COG1064	alcohol dehydrogenase
EP550_00240	COG2818	Glycosylase
EP550_00255	COG1194	a g-specific adenine glycosylase
EP550_00265	COG0400	carboxylic ester hydrolase activity
EP550_00275	COG2983	Belongs to the UPF0260 family
EP550_00280	COG2133	pyrroloquinoline quinone binding
EP550_00285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EP550_00290	COG2116	formate transmembrane transporter activity
EP550_00315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP550_00320	COG1335	isochorismatase
EP550_00325	COG0385	Bile acid
EP550_00330	COG0534	Mate efflux family protein
EP550_00335	COG1683	Conserved Protein
EP550_00355	COG0625	glutathione transferase activity
EP550_00365	COG1113	amino acid transport
EP550_00375	COG0523	cobalamin synthesis protein
EP550_00385	COG2188	Transcriptional regulator
EP550_00415	COG0010	Belongs to the arginase family
EP550_00430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EP550_00475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EP550_00485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EP550_00490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
EP550_00540	COG0753	catalase activity
EP550_00605	COG0534	Mate efflux family protein
EP550_00610	COG0436	Aminotransferase
EP550_00615	COG2733	membrane
EP550_00630	COG2918	glutathione biosynthetic process
EP550_00640	COG3501	Rhs element vgr protein
EP550_00650	COG1388	LysM domain
EP550_00660	COG4372	Transposase
EP550_00680	COG3150	esterase
EP550_00690	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_00695	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EP550_00705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP550_00715	COG2233	PERMEase
EP550_00720	COG2351	hydroxyisourate hydrolase activity
EP550_00755	COG3706	GGDEF domain
EP550_00770	COG1393	Belongs to the ArsC family
EP550_00775	COG0708	Exodeoxyribonuclease III
EP550_00795	COG0189	ligase activity
EP550_00815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EP550_00825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EP550_00840	COG4942	peptidase
EP550_00850	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP550_00860	COG2119	membrane
EP550_00865	COG4774	siderophore transport
EP550_00870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP550_00870	COG0426	domain, Protein
EP550_00895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EP550_00915	COG1902	pentaerythritol trinitrate reductase activity
EP550_00920	COG1519	Transferase
EP550_00925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP550_00930	COG0668	transmembrane transport
EP550_00940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP550_00945	COG1335	isochorismatase
EP550_00950	COG1522	sequence-specific DNA binding
EP550_00975	COG0784	Response regulator, receiver
EP550_00975	COG2205	protein histidine kinase activity
EP550_00975	COG2198	Histidine kinase
EP550_00980	COG3162	membrane
EP550_00985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP550_00995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP550_01005	COG3706	GGDEF domain
EP550_01015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EP550_01020	COG1309	transcriptional regulator
EP550_01040	COG0351	phosphomethylpyrimidine kinase
EP550_01040	COG0352	thiamine-phosphate diphosphorylase activity
EP550_01040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EP550_01050	COG2814	Major facilitator Superfamily
EP550_01065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EP550_01075	COG1113	amino acid transport
EP550_01085	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EP550_01090	COG1012	belongs to the aldehyde dehydrogenase family
EP550_01100	COG1335	isochorismatase
EP550_01115	COG4372	Transposase
EP550_01150	COG2814	Major facilitator Superfamily
EP550_01155	COG0583	DNA-binding transcription factor activity
EP550_01175	COG0667	Aldo Keto reductase
EP550_01210	COG1733	regulation of RNA biosynthetic process
EP550_01220	COG2249	NAD(P)H dehydrogenase (quinone) activity
EP550_01285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EP550_01300	COG2329	Antibiotic biosynthesis monooxygenase
EP550_01330	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EP550_01360	COG0427	acetyl-CoA hydrolase
EP550_01375	COG0745	RESPONSE REGULATOR receiver
EP550_01385	COG0659	secondary active sulfate transmembrane transporter activity
EP550_01390	COG4221	oxidoreductase activity
EP550_01400	COG0488	(ABC) transporter
EP550_01485	COG0833	amino acid
EP550_01530	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EP550_01535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EP550_01550	COG2226	methyltransferase
EP550_01600	COG0070	glutamate synthase
EP550_01600	COG0069	glutamate synthase activity
EP550_01600	COG0067	glutamate synthase
EP550_01605	COG0493	'glutamate synthase
EP550_01615	COG1704	LemA family
EP550_01620	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EP550_01635	COG3307	-O-antigen
EP550_01655	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP550_01670	COG0194	GDP metabolic process
EP550_01720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EP550_01740	COG5380	lipid catabolic process
EP550_01745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EP550_01770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP550_01775	COG0277	FAD linked oxidase domain protein
EP550_01785	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EP550_01790	COG2249	NAD(P)H dehydrogenase (quinone) activity
EP550_01825	COG0628	permease
EP550_01830	COG1192	Involved in chromosome partitioning
EP550_01860	COG0833	amino acid
EP550_01865	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EP550_01870	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP550_01880	COG1012	belongs to the aldehyde dehydrogenase family
EP550_01920	COG0583	DNA-binding transcription factor activity
EP550_01970	COG0517	IMP dehydrogenase activity
EP550_01975	COG1983	PspC domain protein
EP550_01985	COG1960	acyl-CoA dehydrogenase activity
EP550_02000	COG0408	coproporphyrinogen oxidase activity
EP550_02020	COG0513	Belongs to the DEAD box helicase family
EP550_02030	COG1127	ABC transporter
EP550_02035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EP550_02045	COG2854	intermembrane phospholipid transfer
EP550_02055	COG0598	Magnesium transport protein CorA
EP550_02065	COG0494	nUDIX hydrolase
EP550_02070	COG1040	competence protein
EP550_02075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EP550_02095	COG1946	Acyl-CoA thioesterase
EP550_02100	COG1301	dicarboxylic acid transport
EP550_02115	COG1959	2 iron, 2 sulfur cluster binding
EP550_02120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP550_02120	COG1017	nitric oxide dioxygenase activity
EP550_02125	COG0433	COG0433 Predicted ATPase
EP550_02130	COG0626	cystathionine gamma-synthase activity
EP550_02250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EP550_02260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EP550_02285	COG1960	acyl-CoA dehydrogenase activity
EP550_02290	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EP550_02320	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
EP550_02325	COG0339	signal peptide processing
EP550_02330	COG0557	exoribonuclease II activity
EP550_02370	COG0179	Fumarylacetoacetate (FAA) hydrolase
EP550_02375	COG2169	Transcriptional regulator
EP550_02380	COG0697	spore germination
EP550_02385	COG1295	ribonuclease BN
EP550_02420	COG1702	phosphate starvation-inducible protein PhoH
EP550_02430	COG1196	nuclear chromosome segregation
EP550_02430	COG0739	heme binding
EP550_02430	COG0741	lytic transglycosylase activity
EP550_02460	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EP550_02465	COG1183	phosphatidylcholine synthase activity
EP550_02510	COG1960	acyl-CoA dehydrogenase activity
EP550_02515	COG1309	transcriptional regulator
EP550_02530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP550_02535	COG1960	acyl-CoA dehydrogenase activity
EP550_02555	COG2969	positive regulation of protein catabolic process
EP550_02565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EP550_02580	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EP550_02585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EP550_02605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EP550_02615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EP550_02620	COG1408	metallophosphoesterase
EP550_02635	COG2199	diguanylate cyclase activity
EP550_02690	COG3453	Protein conserved in bacteria
EP550_02690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP550_02705	COG1607	acyl-coa hydrolase
EP550_02735	COG2350	Protein conserved in bacteria
EP550_02745	COG0613	PHP domain protein
EP550_02750	COG3781	membrane
EP550_02760	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EP550_02765	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EP550_02775	COG1862	Preprotein translocase
EP550_02805	COG2205	protein histidine kinase activity
EP550_02810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EP550_02830	COG0726	polysaccharide deacetylase
EP550_02835	COG0463	Glycosyl transferase, family 2
EP550_02840	COG0438	transferase activity, transferring glycosyl groups
EP550_02915	COG1960	acyl-CoA dehydrogenase activity
EP550_02920	COG1960	acyl-CoA dehydrogenase activity
EP550_02930	COG2205	protein histidine kinase activity
EP550_02935	COG0745	RESPONSE REGULATOR receiver
EP550_02940	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EP550_02955	COG0584	glycerophosphoryl diester phosphodiesterase
EP550_02960	COG2096	Adenosyltransferase
EP550_02975	COG0133	tryptophan synthase activity
EP550_03010	COG0285	dihydrofolate synthase activity
EP550_03030	COG0450	alkyl hydroperoxide reductase
EP550_03045	COG0477	Major facilitator Superfamily
EP550_03050	COG1272	protein, Hemolysin III
EP550_03080	COG0183	Belongs to the thiolase family
EP550_03085	COG2207	Transcriptional regulator
EP550_03105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP550_03125	COG0183	Belongs to the thiolase family
EP550_03135	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EP550_03135	COG2885	chlorophyll binding
EP550_03140	COG1690	Belongs to the RtcB family
EP550_03145	COG0833	amino acid
EP550_03155	COG2233	PERMEase
EP550_03185	COG2094	Belongs to the DNA glycosylase MPG family
EP550_03195	COG1902	pentaerythritol trinitrate reductase activity
EP550_03210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP550_03215	COG0354	folic acid binding
EP550_03225	COG3189	MarR family transcriptional regulator
EP550_03230	COG2824	Alkylphosphonate utilization operon protein PhnA
EP550_03235	COG3422	double-strand break repair
EP550_03275	COG0840	transmembrane signaling receptor activity
EP550_03295	COG5510	response to toxic substance
EP550_03305	COG2832	Protein of unknown function (DUF454)
EP550_03310	COG1376	ErfK ybiS ycfS ynhG family protein
EP550_03345	COG1289	transmembrane transporter activity
EP550_03350	COG2814	Major facilitator Superfamily
EP550_03370	COG1115	amino acid carrier protein
EP550_03375	COG1752	Esterase of the alpha-beta hydrolase superfamily
EP550_03380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EP550_03385	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EP550_03425	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP550_03435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EP550_03440	COG1077	Cell shape determining protein MreB Mrl
EP550_03445	COG1792	Involved in formation and maintenance of cell shape
EP550_03450	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EP550_03455	COG0424	maF-like protein
EP550_03460	COG1530	ribonuclease E activity
EP550_03470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP550_03490	COG2249	NAD(P)H dehydrogenase (quinone) activity
EP550_03515	COG2207	Transcriptional regulator
EP550_03535	COG1113	amino acid transport
EP550_03540	COG2828	Protein conserved in bacteria
EP550_03545	COG0142	geranyltranstransferase activity
EP550_03550	COG2315	Protein conserved in bacteria
EP550_03565	COG1752	Esterase of the alpha-beta hydrolase superfamily
EP550_03585	COG2194	sulfuric ester hydrolase activity
EP550_03590	COG0745	RESPONSE REGULATOR receiver
EP550_03595	COG0642	Histidine kinase
EP550_03605	COG0004	ammonium transporteR
EP550_03615	COG0583	DNA-binding transcription factor activity
EP550_03635	COG0525	valine-tRNA ligase activity
EP550_03645	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_03655	COG0393	Putative heavy-metal-binding
EP550_03660	COG0393	Putative heavy-metal-binding
EP550_03665	COG1538	Outer membrane efflux protein
EP550_03675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP550_03680	COG0671	phosphoesterase, PA-phosphatase related
EP550_03710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EP550_03725	COG1648	precorrin-2 dehydrogenase activity
EP550_03725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EP550_03730	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EP550_03735	COG1733	regulation of RNA biosynthetic process
EP550_03745	COG0531	amino acid
EP550_03760	COG0321	lipoyl(octanoyl) transferase activity
EP550_03765	COG2921	Belongs to the UPF0250 family
EP550_03805	COG2009	succinate dehydrogenase
EP550_03810	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EP550_03815	COG1053	succinate dehydrogenase
EP550_03820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EP550_03845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP550_03865	COG2354	Protein conserved in bacteria
EP550_03870	COG2321	neutral zinc metallopeptidase
EP550_03945	COG2843	Capsule synthesis protein
EP550_03960	COG0589	response to stress
EP550_03980	COG0505	Belongs to the CarA family
EP550_04005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP550_04010	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EP550_04065	COG0477	Major facilitator Superfamily
EP550_04070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EP550_04090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EP550_04115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP550_04120	COG0584	glycerophosphoryl diester phosphodiesterase
EP550_04140	COG0741	lytic transglycosylase activity
EP550_04165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EP550_04180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP550_04210	COG0778	Nitroreductase
EP550_04225	COG1929	Belongs to the glycerate kinase type-1 family
EP550_04230	COG0243	molybdopterin cofactor binding
EP550_04235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EP550_04240	COG3339	Conserved Protein
EP550_04250	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
EP550_04265	COG1113	amino acid transport
EP550_04275	COG0019	diaminopimelate decarboxylase activity
EP550_04285	COG1280	lysine exporter protein (LysE YggA)
EP550_04290	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EP550_04320	COG0463	Glycosyl transferase, family 2
EP550_04340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP550_04370	COG4591	ABC-type transport system involved in lipoprotein release permease component
EP550_04375	COG1136	(ABC) transporter
EP550_04380	COG0658	competence protein
EP550_04380	COG2333	competence protein COMEC
EP550_04390	COG0616	signal peptide processing
EP550_04390	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EP550_04395	COG0596	Alpha beta hydrolase
EP550_04400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EP550_04410	COG0628	permease
EP550_04455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP550_04475	COG0823	Involved in the tonB-independent uptake of proteins
EP550_04495	COG0824	Thioesterase
EP550_04500	COG1473	amidohydrolase
EP550_04520	COG0047	phosphoribosylformylglycinamidine synthase activity
EP550_04520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EP550_04525	COG2814	Major facilitator Superfamily
EP550_04530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EP550_04535	COG1024	Enoyl-CoA hydratase
EP550_04540	COG1051	belongs to the nudix hydrolase family
EP550_04540	COG1056	cytidyltransferase-related domain
EP550_04550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EP550_04565	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EP550_04580	COG4625	pathogenesis
EP550_04585	COG0583	DNA-binding transcription factor activity
EP550_04590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EP550_04595	COG4208	sulfate ABC transporter
EP550_04600	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
EP550_04610	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EP550_04615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EP550_04620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EP550_04640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP550_04655	COG0681	Belongs to the peptidase S26 family
EP550_04670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EP550_04680	COG1381	Involved in DNA repair and RecF pathway recombination
EP550_04685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EP550_04695	COG4221	oxidoreductase activity
EP550_04745	COG0556	nucleotide-excision repair
EP550_04810	COG2070	2-Nitropropane dioxygenase
EP550_04840	COG1215	transferase activity, transferring glycosyl groups
EP550_04855	COG0415	Belongs to the DNA photolyase family
EP550_04865	COG1252	NADH dehydrogenase
EP550_04870	COG1686	Belongs to the peptidase S11 family
EP550_04885	COG1187	pseudouridine synthase activity
EP550_04910	COG0477	Major facilitator Superfamily
EP550_04915	COG0583	DNA-binding transcription factor activity
EP550_04930	COG0612	Peptidase, M16
EP550_04955	COG0352	thiamine-phosphate diphosphorylase activity
EP550_04990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP550_05005	COG1309	transcriptional regulator
EP550_05015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EP550_05020	COG0076	glutamate decarboxylase activity
EP550_05030	COG1522	sequence-specific DNA binding
EP550_05035	COG3961	Belongs to the TPP enzyme family
EP550_05040	COG1113	amino acid transport
EP550_05045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EP550_05050	COG0573	inorganic phosphate transmembrane transporter activity
EP550_05060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EP550_05065	COG0616	signal peptide processing
EP550_05100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EP550_05105	COG1686	Belongs to the peptidase S11 family
EP550_05130	COG0583	DNA-binding transcription factor activity
EP550_05135	COG1067	ATP-dependent peptidase activity
EP550_05180	COG1966	Carbon starvation protein
EP550_05185	COG2879	small protein
EP550_05220	COG2508	Transcriptional regulator
EP550_05220	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EP550_05240	COG1113	amino acid transport
EP550_05245	COG0583	DNA-binding transcription factor activity
EP550_05250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP550_05255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP550_05270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP550_05275	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EP550_05275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP550_05310	COG2814	Major facilitator Superfamily
EP550_05315	COG4948	Mandelate Racemase Muconate Lactonizing
EP550_05325	COG1309	transcriptional regulator
EP550_05345	COG1741	Belongs to the pirin family
EP550_05355	COG2964	Protein conserved in bacteria
EP550_05370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP550_05375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EP550_05380	COG4605	iron ion homeostasis
EP550_05385	COG4604	ABC transporter, ATP-binding protein
EP550_05390	COG4607	ABC-type enterochelin transport system periplasmic component
EP550_05395	COG4774	siderophore transport
EP550_05415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EP550_05420	COG1021	2,3-dihydroxybenzoate-AMP ligase
EP550_05425	COG3433	isochorismatase activity
EP550_05425	COG1535	isochorismatase
EP550_05440	COG1132	(ABC) transporter
EP550_05450	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
EP550_05460	COG1169	isochorismate synthase
EP550_05475	COG3739	integral membrane protein
EP550_05510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EP550_05540	COG0308	aminopeptidase N
EP550_05545	COG0512	Glutamine amidotransferase of anthranilate synthase
EP550_05760	COG4372	Transposase
EP550_05840	COG1598	PFAM Uncharacterised protein family UPF0150
EP550_05855	COG2194	sulfuric ester hydrolase activity
EP550_05890	COG0006	proline dipeptidase activity
EP550_05895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP550_05900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP550_05920	COG1279	arginine transmembrane transporter activity
EP550_05925	COG0583	DNA-binding transcription factor activity
EP550_05965	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EP550_05970	COG1388	LysM domain
EP550_05970	COG0741	lytic transglycosylase activity
EP550_05970	COG1388	LysM domain
EP550_05970	COG0741	lytic transglycosylase activity
EP550_05980	COG4174	ABC transporter (Permease)
EP550_05985	COG4239	(ABC) transporter, permease
EP550_05990	COG4172	Belongs to the ABC transporter superfamily
EP550_06010	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EP550_06020	COG5001	Diguanylate cyclase
EP550_06020	COG2203	Gaf domain
EP550_06020	COG3706	GGDEF domain
EP550_06020	COG4251	negative regulation of phosphorylation
EP550_06030	COG1902	pentaerythritol trinitrate reductase activity
EP550_06030	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP550_06045	COG4269	membrane
EP550_06065	COG3501	Rhs element vgr protein
EP550_06075	COG3316	Transposase and inactivated derivatives
EP550_06085	COG1309	transcriptional regulator
EP550_06090	COG1741	Belongs to the pirin family
EP550_06100	COG2826	transposase and inactivated derivatives, IS30 family
EP550_06110	COG2072	flavoprotein involved in K transport
EP550_06120	COG2252	PERMEase
EP550_06125	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EP550_06130	COG3038	cytochrome b561
EP550_06140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EP550_06160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EP550_06170	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EP550_06185	COG0667	Aldo Keto reductase
EP550_06195	COG1765	OsmC-like protein
EP550_06245	COG2885	chlorophyll binding
EP550_06255	COG0625	glutathione transferase activity
EP550_06260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EP550_06280	COG3634	alkyl hydroperoxide reductase activity
EP550_06290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EP550_06300	COG0450	alkyl hydroperoxide reductase
EP550_06305	COG1643	Atp-dependent helicase
EP550_06320	COG2814	Major facilitator Superfamily
EP550_06325	COG3135	benzoate transporter
EP550_06330	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_06335	COG0543	2 iron, 2 sulfur cluster binding
EP550_06335	COG0633	Ferredoxin
EP550_06340	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EP550_06345	COG4638	Rieske (2fe-2S)
EP550_06350	COG0583	DNA-binding transcription factor activity
EP550_06415	COG1570	exodeoxyribonuclease VII activity
EP550_06450	COG1280	lysine exporter protein (LysE YggA)
EP550_06455	COG1278	Cold shock
EP550_06495	COG2814	Major facilitator Superfamily
EP550_06500	COG1733	regulation of RNA biosynthetic process
EP550_06515	COG2826	transposase and inactivated derivatives, IS30 family
EP550_06540	COG0517	IMP dehydrogenase activity
EP550_06540	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EP550_06545	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EP550_06555	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
EP550_06560	COG1137	ATPase activity
EP550_06565	COG1538	Outer membrane efflux protein
EP550_06605	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EP550_06620	COG1522	sequence-specific DNA binding
EP550_06625	COG5006	permease, DMT superfamily
EP550_06635	COG1560	Kdo2-lipid A biosynthetic process
EP550_06650	COG2814	Major facilitator Superfamily
EP550_06670	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP550_06705	COG3501	Rhs element vgr protein
EP550_06710	COG3209	COG3209 Rhs family protein
EP550_06725	COG0583	DNA-binding transcription factor activity
EP550_06730	COG1914	H( )-stimulated, divalent metal cation uptake system
EP550_06750	COG4770	biotin carboxylase activity
EP550_06755	COG0038	chloride channel
EP550_06785	COG1309	transcriptional regulator
EP550_06820	COG0439	Biotin carboxylase
EP550_06825	COG2249	NAD(P)H dehydrogenase (quinone) activity
EP550_06845	COG0864	Transcriptional regulator
EP550_06855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP550_06860	COG1116	anion transmembrane transporter activity
EP550_06935	COG2885	chlorophyll binding
EP550_06935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EP550_06975	COG0583	DNA-binding transcription factor activity
EP550_06985	COG0590	tRNA wobble adenosine to inosine editing
EP550_06990	COG2807	transmembrane transport
EP550_07005	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EP550_07015	COG0789	Transcriptional regulator
EP550_07030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP550_07050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP550_07060	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP550_07075	COG1012	belongs to the aldehyde dehydrogenase family
EP550_07080	COG0531	amino acid
EP550_07085	COG1760	l-serine dehydratase
EP550_07090	COG1012	belongs to the aldehyde dehydrogenase family
EP550_07090	COG2030	dehydratase
EP550_07095	COG3396	Phenylacetate-CoA oxygenase
EP550_07100	COG3460	Phenylacetate-CoA oxygenase
EP550_07105	COG3396	Phenylacetate-CoA oxygenase
EP550_07110	COG2151	metal-sulfur cluster biosynthetic enzyme
EP550_07115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP550_07120	COG1024	Enoyl-CoA hydratase
EP550_07125	COG1024	Enoyl-CoA hydratase
EP550_07130	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP550_07135	COG0183	Belongs to the thiolase family
EP550_07140	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
EP550_07145	COG3327	negative regulation of DNA-templated transcription, initiation
EP550_07155	COG2050	protein possibly involved in aromatic compounds catabolism
EP550_07165	COG0556	nucleotide-excision repair
EP550_07205	COG1278	Cold shock
EP550_07215	COG2207	Transcriptional regulator
EP550_07225	COG3316	Transposase and inactivated derivatives
EP550_07230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EP550_07285	COG3316	Transposase and inactivated derivatives
EP550_07295	COG1414	Transcriptional regulator
EP550_07300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP550_07315	COG3842	ATPase activity
EP550_07330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EP550_07335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EP550_07340	COG2814	Major facilitator Superfamily
EP550_07345	COG1960	acyl-CoA dehydrogenase activity
EP550_07360	COG1024	Enoyl-CoA hydratase
EP550_07370	COG2814	Major facilitator Superfamily
EP550_07380	COG0183	Belongs to the thiolase family
EP550_07385	COG1250	3-hydroxyacyl-CoA dehydrogenase
EP550_07390	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_07395	COG1024	Enoyl-CoA hydratase
EP550_07400	COG1960	acyl-CoA dehydrogenase activity
EP550_07405	COG2814	Major facilitator Superfamily
EP550_07410	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EP550_07415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EP550_07425	COG2814	Major facilitator Superfamily
EP550_07435	COG1960	acyl-CoA dehydrogenase activity
EP550_07450	COG0583	DNA-binding transcription factor activity
EP550_07465	COG1024	Enoyl-CoA hydratase
EP550_07470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EP550_07475	COG1960	acyl-CoA dehydrogenase activity
EP550_07480	COG1309	transcriptional regulator
EP550_07485	COG0318	PFAM AMP-dependent synthetase and ligase
EP550_07505	COG0583	DNA-binding transcription factor activity
EP550_07550	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_07570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EP550_07590	COG0784	Response regulator, receiver
EP550_07590	COG2205	protein histidine kinase activity
EP550_07610	COG0765	amino acid transport
EP550_07615	COG0765	amino acid transport
EP550_07620	COG1126	abc transporter atp-binding protein
EP550_07625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP550_07630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EP550_07645	COG1280	lysine exporter protein (LysE YggA)
EP550_07655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EP550_07660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP550_07665	COG1045	serine acetyltransferase
EP550_07680	COG0583	DNA-binding transcription factor activity
EP550_07685	COG0625	glutathione transferase activity
EP550_07690	COG0625	glutathione transferase activity
EP550_07695	COG0583	DNA-binding transcription factor activity
EP550_07705	COG1346	cytolysis
EP550_07725	COG2814	Major facilitator Superfamily
EP550_07735	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
EP550_07740	COG3052	prosthetic group binding
EP550_07760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EP550_07780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP550_07790	COG1294	oxidase, subunit
EP550_07795	COG1271	oxidase subunit
EP550_07820	COG0477	Major facilitator Superfamily
EP550_07840	COG4521	taurine ABC transporter
EP550_07845	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EP550_07850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP550_07855	COG2175	clavaminate synthase activity
EP550_07865	COG1953	Uracil, thiamine, allantoin
EP550_07875	COG0583	DNA-binding transcription factor activity
EP550_07885	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EP550_07900	COG0640	Transcriptional regulator
EP550_07905	COG0798	PFAM Bile acid sodium symporter
EP550_07910	COG0583	DNA-binding transcription factor activity
EP550_07925	COG3634	alkyl hydroperoxide reductase activity
EP550_07970	COG0436	Aminotransferase
EP550_07980	COG0386	Belongs to the glutathione peroxidase family
EP550_08020	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EP550_08045	COG0012	GTP binding
EP550_08050	COG2011	ABC-type metal ion transport system permease component
EP550_08055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EP550_08065	COG1464	Belongs to the NlpA lipoprotein family
EP550_08095	COG0765	amino acid transport
EP550_08100	COG0765	amino acid transport
EP550_08105	COG1126	abc transporter atp-binding protein
EP550_08115	COG1522	sequence-specific DNA binding
EP550_08130	COG1309	transcriptional regulator
EP550_08160	COG0583	DNA-binding transcription factor activity
EP550_08170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EP550_08180	COG0697	spore germination
EP550_08215	COG3121	Chaperone
EP550_08220	COG3539	Fimbrial protein
EP550_08245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EP550_08245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EP550_08295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EP550_08305	COG2353	YceI-like domain
EP550_08315	COG3698	Phosphodiester glycosidase
EP550_08330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EP550_08335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EP550_08335	COG0506	proline dehydrogenase activity
EP550_08335	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
EP550_08345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EP550_08350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EP550_08370	COG1132	(ABC) transporter
EP550_08375	COG3122	Protein conserved in bacteria
EP550_08380	COG3619	membrane
EP550_08390	COG0640	Transcriptional regulator
EP550_08400	COG2850	peptidyl-arginine hydroxylation
EP550_08405	COG0424	maF-like protein
EP550_08425	COG0191	fructose-bisphosphate aldolase activity
EP550_08430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP550_08445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EP550_08455	COG1192	Involved in chromosome partitioning
EP550_08460	COG1475	DNA binding
EP550_08465	COG0811	peptide transport
EP550_08475	COG1132	(ABC) transporter
EP550_08480	COG1663	tetraacyldisaccharide 4'-kinase activity
EP550_08500	COG0084	hydrolase, TatD family'
EP550_08515	COG2165	general secretion pathway protein
EP550_08545	COG0590	tRNA wobble adenosine to inosine editing
EP550_08565	COG0776	regulation of translation
EP550_08595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EP550_08665	COG0305	Participates in initiation and elongation during chromosome replication
EP550_08740	COG4695	Portal protein
EP550_08795	COG0739	heme binding
EP550_08795	COG0741	lytic transglycosylase activity
EP550_08795	COG1196	nuclear chromosome segregation
EP550_08850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EP550_08900	COG0339	signal peptide processing
EP550_08910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EP550_08945	COG0702	epimerase
EP550_08950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP550_08970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EP550_09000	COG0316	Belongs to the HesB IscA family
EP550_09005	COG0822	iron-sulfur transferase activity
EP550_09030	COG0776	regulation of translation
EP550_09035	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EP550_09040	COG2207	Transcriptional regulator
EP550_09045	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP550_09050	COG1960	acyl-CoA dehydrogenase activity
EP550_09055	COG1960	acyl-CoA dehydrogenase activity
EP550_09070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EP550_09090	COG4264	IucA IucC family
EP550_09095	COG4264	IucA IucC family
EP550_09155	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EP550_09175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EP550_09180	COG0730	response to heat
EP550_09200	COG4773	Receptor
EP550_09205	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP550_09215	COG4372	Transposase
EP550_09240	COG1131	(ABC) transporter
EP550_09245	COG0842	Transport permease protein
EP550_09250	COG0842	Transport permease protein
EP550_09305	COG2226	methyltransferase
EP550_09330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EP550_09365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EP550_09375	COG0133	tryptophan synthase activity
EP550_09405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EP550_09410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EP550_09415	COG0022	dehydrogenase e1 component
EP550_09420	COG0508	dehydrogenase complex catalyzes the overall conversion of
EP550_09425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP550_09435	COG1063	alcohol dehydrogenase
EP550_09440	COG3781	membrane
EP550_09450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP550_09450	COG3453	Protein conserved in bacteria
EP550_09460	COG0730	response to heat
EP550_09475	COG2207	Transcriptional regulator
EP550_09475	COG3708	Transcriptional regulator
EP550_09480	COG1733	regulation of RNA biosynthetic process
EP550_09485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EP550_09510	COG4521	taurine ABC transporter
EP550_09515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP550_09535	COG0477	Major facilitator Superfamily
EP550_09545	COG1027	Aspartate ammonia-lyase
EP550_09560	COG0583	DNA-binding transcription factor activity
EP550_09565	COG0583	DNA-binding transcription factor activity
EP550_09570	COG0183	Belongs to the thiolase family
EP550_09575	COG2031	fatty acid transporter
EP550_09580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EP550_09590	COG0583	DNA-binding transcription factor activity
EP550_09600	COG2610	gluconate transmembrane transporter activity
EP550_09605	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_09610	COG2207	Transcriptional regulator
EP550_09620	COG0412	Dienelactone hydrolase
EP550_09625	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_09635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP550_09650	COG0543	2 iron, 2 sulfur cluster binding
EP550_09650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EP550_09655	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EP550_09660	COG4638	Rieske (2fe-2S)
EP550_09670	COG0725	ABC transporter, periplasmic molybdate-binding protein
EP550_09675	COG4149	molybdate abc transporter
EP550_09680	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EP550_09685	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_09690	COG3433	isochorismatase activity
EP550_09690	COG1535	isochorismatase
EP550_09770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EP550_09785	COG0753	catalase activity
EP550_09795	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EP550_09820	COG3539	Fimbrial protein
EP550_09840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EP550_09860	COG2072	flavoprotein involved in K transport
EP550_09870	COG1538	Outer membrane efflux protein
EP550_09875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EP550_09880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP550_09885	COG0745	RESPONSE REGULATOR receiver
EP550_09890	COG2205	protein histidine kinase activity
EP550_09900	COG2207	Transcriptional regulator
EP550_09915	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_09970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EP550_10090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EP550_10110	COG1120	ATPase activity
EP550_10125	COG1064	alcohol dehydrogenase
EP550_10140	COG2207	Transcriptional regulator
EP550_10145	COG2084	Dehydrogenase
EP550_10155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EP550_10160	COG0583	DNA-binding transcription factor activity
EP550_10170	COG0129	dihydroxy-acid dehydratase activity
EP550_10175	COG1012	belongs to the aldehyde dehydrogenase family
EP550_10190	COG1566	PFAM secretion protein HlyD family protein
EP550_10210	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EP550_10215	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EP550_10240	COG0583	DNA-binding transcription factor activity
EP550_10285	COG3210	domain, Protein
EP550_10290	COG2831	hemolysin activation secretion protein
EP550_10305	COG1473	amidohydrolase
EP550_10315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP550_10315	COG0475	glutathione-regulated potassium exporter activity
EP550_10325	COG0583	DNA-binding transcription factor activity
EP550_10330	COG1335	isochorismatase
EP550_10350	COG1309	transcriptional regulator
EP550_10380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EP550_10390	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP550_10390	COG1902	pentaerythritol trinitrate reductase activity
EP550_10395	COG1846	Transcriptional regulator
EP550_10420	COG0753	catalase activity
EP550_10435	COG1012	belongs to the aldehyde dehydrogenase family
EP550_10450	COG3162	membrane
EP550_10460	COG3829	transcription factor binding
EP550_10465	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_10470	COG1960	acyl-CoA dehydrogenase activity
EP550_10490	COG1012	belongs to the aldehyde dehydrogenase family
EP550_10510	COG2186	Transcriptional regulator
EP550_10520	COG0583	DNA-binding transcription factor activity
EP550_10525	COG4948	Mandelate Racemase Muconate Lactonizing
EP550_10530	COG4829	muconolactone delta-isomerase
EP550_10540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EP550_10545	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EP550_10550	COG0183	Belongs to the thiolase family
EP550_10555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EP550_10565	COG1012	belongs to the aldehyde dehydrogenase family
EP550_10575	COG3733	amine oxidase
EP550_10585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP550_10595	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_10605	COG4638	Rieske (2fe-2S)
EP550_10625	COG0154	amidase activity
EP550_10635	COG2814	Major facilitator Superfamily
EP550_10660	COG1960	acyl-CoA dehydrogenase activity
EP550_10665	COG0583	DNA-binding transcription factor activity
EP550_10670	COG1414	Transcriptional regulator
EP550_10685	COG2391	methyltransferase activity
EP550_10695	COG4993	Dehydrogenase
EP550_10700	COG3659	wide pore channel activity
EP550_10705	COG3420	alginic acid biosynthetic process
EP550_10710	COG0710	3-dehydroquinate dehydratase activity
EP550_10715	COG3485	protocatechuate 3,4-dioxygenase
EP550_10720	COG3485	protocatechuate 3,4-dioxygenase
EP550_10725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EP550_10730	COG2271	Major facilitator Superfamily
EP550_10735	COG0596	Alpha beta hydrolase
EP550_10740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EP550_10745	COG0183	Belongs to the thiolase family
EP550_10750	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EP550_10755	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EP550_10765	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EP550_10770	COG2323	membrane
EP550_10815	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP550_10815	COG1902	pentaerythritol trinitrate reductase activity
EP550_10830	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EP550_10840	COG0542	response to heat
EP550_10845	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EP550_10875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EP550_10880	COG0569	domain protein
EP550_10885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EP550_10900	COG4774	siderophore transport
EP550_10905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EP550_10915	COG1585	Membrane protein implicated in regulation of membrane protease activity
EP550_10920	COG2826	transposase and inactivated derivatives, IS30 family
EP550_10940	COG1294	oxidase, subunit
EP550_10945	COG4890	Cyd operon protein YbgT
EP550_10960	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
EP550_10970	COG0552	protein localization to endoplasmic reticulum
EP550_10995	COG0517	IMP dehydrogenase activity
EP550_10995	COG0516	GMP reductase activity
EP550_11000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EP550_11005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EP550_11015	COG0583	DNA-binding transcription factor activity
EP550_11020	COG0024	Methionine aminopeptidase
EP550_11050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EP550_11050	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP550_11055	COG1105	Belongs to the carbohydrate kinase PfkB family
EP550_11060	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EP550_11060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EP550_11060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EP550_11080	COG3300	MHYT domain
EP550_11080	COG5001	Diguanylate cyclase
EP550_11095	COG2135	peptidase activity
EP550_11100	COG0659	secondary active sulfate transmembrane transporter activity
EP550_11115	COG1113	amino acid transport
EP550_11125	COG1522	sequence-specific DNA binding
EP550_11150	COG1011	Hydrolase
EP550_11155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EP550_11165	COG2137	regulation of response to DNA damage stimulus
EP550_11180	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP550_11215	COG0575	Belongs to the CDS family
EP550_11220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EP550_11245	COG3852	Histidine kinase
EP550_11250	COG2204	response regulator
EP550_11310	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP550_11315	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
EP550_11335	COG0697	spore germination
EP550_11340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP550_11350	COG0303	'Molybdopterin
EP550_11355	COG0521	Mo-molybdopterin cofactor biosynthetic process
EP550_11355	COG0315	cyclic pyranopterin monophosphate synthase activity
EP550_11370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EP550_11375	COG0243	molybdopterin cofactor binding
EP550_11385	COG0243	molybdopterin cofactor binding
EP550_11390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP550_11395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP550_11395	COG2146	nitrite reductase [NAD(P)H] activity
EP550_11405	COG0745	RESPONSE REGULATOR receiver
EP550_11410	COG1116	anion transmembrane transporter activity
EP550_11410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP550_11430	COG0511	ligase activity, forming carbon-carbon bonds
EP550_11445	COG2814	Major facilitator Superfamily
EP550_11470	COG1598	PFAM Uncharacterised protein family UPF0150
EP550_11590	COG5410	chromosome segregation
EP550_11745	COG0069	glutamate synthase activity
EP550_11765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EP550_11775	COG1454	alcohol dehydrogenase
EP550_11780	COG0824	Thioesterase
EP550_11790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EP550_11820	COG0183	Belongs to the thiolase family
EP550_11830	COG0583	DNA-binding transcription factor activity
EP550_11845	COG1522	sequence-specific DNA binding
EP550_11850	COG3135	benzoate transporter
EP550_11860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EP550_11875	COG0589	response to stress
EP550_11880	COG0488	(ABC) transporter
EP550_11900	COG4773	Receptor
EP550_11935	COG0668	transmembrane transport
EP550_11945	COG1309	transcriptional regulator
EP550_11965	COG1605	Chorismate mutase
EP550_11975	COG4221	oxidoreductase activity
EP550_11985	COG0308	aminopeptidase N
EP550_12005	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
EP550_12015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP550_12020	COG1454	alcohol dehydrogenase
EP550_12040	COG0531	amino acid
EP550_12045	COG4303	Ethanolamine ammonia lyase large subunit
EP550_12050	COG4302	ethanolamine ammonia-lyase activity
EP550_12055	COG0519	Catalyzes the synthesis of GMP from XMP
EP550_12055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EP550_12080	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EP550_12095	COG0697	spore germination
EP550_12100	COG1923	regulation of RNA biosynthetic process
EP550_12110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EP550_12115	COG0802	atpase or kinase
EP550_12135	COG1187	pseudouridine synthase activity
EP550_12150	COG0583	DNA-binding transcription factor activity
EP550_12165	COG2814	Major facilitator Superfamily
EP550_12170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EP550_12200	COG0729	surface antigen
EP550_12220	COG0174	glutamine synthetase
EP550_12225	COG0745	RESPONSE REGULATOR receiver
EP550_12230	COG2205	protein histidine kinase activity
EP550_12240	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EP550_12245	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EP550_12270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP550_12275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP550_12280	COG1960	acyl-CoA dehydrogenase activity
EP550_12295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP550_12300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP550_12320	COG0583	DNA-binding transcription factor activity
EP550_12340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP550_12350	COG3658	cytochrome
EP550_12355	COG1215	transferase activity, transferring glycosyl groups
EP550_12360	COG1649	PFAM Uncharacterised BCR, COG1649
EP550_12360	COG0726	polysaccharide deacetylase
EP550_12385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EP550_12390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EP550_12400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EP550_12425	COG0305	Participates in initiation and elongation during chromosome replication
EP550_12430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EP550_12440	COG1305	Transglutaminase-like
EP550_12450	COG2308	Evidence 4 Homologs of previously reported genes of
EP550_12480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EP550_12485	COG0138	bifunctional purine biosynthesis protein purh
EP550_12490	COG0151	Belongs to the GarS family
EP550_12495	COG1464	Belongs to the NlpA lipoprotein family
EP550_12500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EP550_12505	COG2011	ABC-type metal ion transport system permease component
EP550_12510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP550_12520	COG1301	dicarboxylic acid transport
EP550_12550	COG1794	racemase activity, acting on amino acids and derivatives
EP550_12560	COG3008	intermembrane lipid transfer
EP550_12560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EP550_12565	COG2995	paraquat-inducible protein a
EP550_12575	COG2985	domain, Protein
EP550_12605	COG0477	Major facilitator Superfamily
EP550_12660	COG2186	Transcriptional regulator
EP550_12670	COG0786	glutamate:sodium symporter activity
EP550_12675	COG3243	poly(R)-hydroxyalkanoic acid synthase
EP550_12700	COG3111	PFAM Bacterial OB fold (BOF) protein
EP550_12795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EP550_12800	COG1610	YqeY-like protein
EP550_12805	COG4783	chaperone-mediated protein folding
EP550_12830	COG1286	toxin biosynthetic process
EP550_12860	COG0778	Nitroreductase
EP550_12870	COG0513	Belongs to the DEAD box helicase family
EP550_12890	COG2363	Small membrane protein
EP550_12920	COG1234	tRNA 3'-trailer cleavage
EP550_12925	COG2195	Cleaves the N-terminal amino acid of tripeptides
EP550_12935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EP550_12945	COG2819	hydrolase of the alpha beta superfamily
EP550_12950	COG1960	acyl-CoA dehydrogenase activity
EP550_12955	COG1301	dicarboxylic acid transport
EP550_12965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EP550_12970	COG3139	Protein of unknown function (DUF1315)
EP550_12975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EP550_12980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EP550_12990	COG0494	nUDIX hydrolase
EP550_13000	COG0642	Histidine kinase
EP550_13005	COG0745	RESPONSE REGULATOR receiver
EP550_13025	COG1720	tRNA m6t6A37 methyltransferase activity
EP550_13040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP550_13050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EP550_13060	COG4598	ABC transporter
EP550_13065	COG4160	amino acid transport
EP550_13070	COG4215	(ABC) transporter
EP550_13085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP550_13095	COG1538	Outer membrane efflux protein
EP550_13130	COG1131	(ABC) transporter
EP550_13135	COG0842	Transport permease protein
EP550_13150	COG0772	Belongs to the SEDS family
EP550_13155	COG2951	lytic endotransglycosylase activity
EP550_13180	COG2207	Transcriptional regulator
EP550_13195	COG0052	Belongs to the universal ribosomal protein uS2 family
EP550_13200	COG0024	Methionine aminopeptidase
EP550_13210	COG2223	nitrite transmembrane transporter activity
EP550_13220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EP550_13225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EP550_13230	COG1960	acyl-CoA dehydrogenase activity
EP550_13245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EP550_13250	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EP550_13255	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EP550_13275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EP550_13280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EP550_13285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EP550_13320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EP550_13335	COG3104	oligopeptide transport
EP550_13345	COG0582	viral genome integration into host DNA
EP550_13540	COG5410	chromosome segregation
EP550_13730	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EP550_13755	COG3384	dioxygenase
EP550_13765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EP550_13770	COG2878	Part of a membrane complex involved in electron transport
EP550_13775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EP550_13800	COG0768	penicillin binding
EP550_13805	COG0742	ribosomal rna small subunit methyltransferase
EP550_13820	COG0830	nickel cation binding
EP550_13830	COG0804	urea catabolic process
EP550_13870	COG1253	flavin adenine dinucleotide binding
EP550_13880	COG2851	Citrate transporter
EP550_13930	COG1773	rubredoxin
EP550_13935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EP550_13945	COG0583	DNA-binding transcription factor activity
EP550_13975	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EP550_13980	COG4181	ATPase activity
EP550_14025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EP550_14045	COG0306	phosphate transporter
EP550_14055	COG3958	Transketolase
EP550_14060	COG3959	Transketolase, thiamine diphosphate binding domain
EP550_14065	COG2271	Major facilitator Superfamily
EP550_14070	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_14075	COG0583	DNA-binding transcription factor activity
EP550_14095	COG2223	nitrite transmembrane transporter activity
EP550_14100	COG2207	Transcriptional regulator
EP550_14105	COG2066	Belongs to the glutaminase family
EP550_14110	COG0242	peptide deformylase activity
EP550_14115	COG0477	Major facilitator Superfamily
EP550_14125	COG0028	Belongs to the TPP enzyme family
EP550_14140	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_14145	COG2267	carboxylic ester hydrolase activity
EP550_14155	COG2271	Major facilitator Superfamily
EP550_14160	COG0446	pyridine nucleotide-disulphide oxidoreductase
EP550_14170	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_14190	COG1414	Transcriptional regulator
EP550_14205	COG1024	Enoyl-CoA hydratase
EP550_14215	COG1215	transferase activity, transferring glycosyl groups
EP550_14220	COG1649	PFAM Uncharacterised BCR, COG1649
EP550_14220	COG0726	polysaccharide deacetylase
EP550_14230	COG4681	YaeQ
EP550_14240	COG0523	cobalamin synthesis protein
EP550_14250	COG1607	acyl-coa hydrolase
EP550_14260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP550_14265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EP550_14270	COG1309	transcriptional regulator
EP550_14295	COG2040	homocysteine
EP550_14300	COG0531	amino acid
EP550_14360	COG1595	DNA-templated transcription, initiation
EP550_14370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP550_14375	COG0477	Major facilitator Superfamily
EP550_14425	COG0405	Gamma-glutamyltransferase
EP550_14430	COG2814	Major facilitator Superfamily
EP550_14440	COG2050	protein possibly involved in aromatic compounds catabolism
EP550_14455	COG1090	epimerase
EP550_14475	COG0420	3'-5' exonuclease activity
EP550_14500	COG0735	belongs to the Fur family
EP550_14505	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EP550_14530	COG0121	glutamine amidotransferase
EP550_14545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP550_14555	COG0210	DNA helicase
EP550_14560	COG2885	chlorophyll binding
EP550_14565	COG0204	Acyl-transferase
EP550_14580	COG2894	cell division
EP550_14600	COG1280	lysine exporter protein (LysE YggA)
EP550_14615	COG4372	Transposase
EP550_14620	COG1674	ftsk spoiiie
EP550_14620	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
EP550_14625	COG0492	ferredoxin-NADP+ reductase activity
EP550_14630	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EP550_14640	COG0456	acetyltransferase
EP550_14700	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP550_14700	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EP550_14720	COG1012	belongs to the aldehyde dehydrogenase family
EP550_14740	COG0473	3-isopropylmalate dehydrogenase activity
EP550_14745	COG0583	DNA-binding transcription factor activity
EP550_14765	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EP550_14790	COG0564	pseudouridine synthase activity
EP550_14800	COG0358	DNA primase activity
EP550_14815	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
EP550_14835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EP550_14865	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EP550_14875	COG0351	phosphomethylpyrimidine kinase
EP550_14875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EP550_14875	COG0352	thiamine-phosphate diphosphorylase activity
EP550_14880	COG1652	LysM domain
EP550_14905	COG1399	metal-binding, possibly nucleic acid-binding protein
EP550_14910	COG3101	peptidyl-lysine hydroxylation
EP550_14915	COG0009	L-threonylcarbamoyladenylate synthase
EP550_14920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EP550_14925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EP550_14940	COG4106	trans-aconitate 2-methyltransferase activity
EP550_14955	COG2226	methyltransferase
EP550_14955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EP550_14955	COG0596	Alpha beta hydrolase
EP550_14960	COG1877	trehalose-phosphatase activity
EP550_14965	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EP550_14970	COG2223	nitrite transmembrane transporter activity
EP550_14990	COG1196	nuclear chromosome segregation
EP550_15000	COG0730	response to heat
EP550_15015	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EP550_15025	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP550_15085	COG0489	protein tyrosine kinase activity
EP550_15095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP550_15095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP550_15125	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EP550_15130	COG2081	HI0933 family
EP550_15140	COG0668	transmembrane transport
EP550_15160	COG0583	DNA-binding transcription factor activity
EP550_15180	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EP550_15185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EP550_15215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EP550_15250	COG2205	protein histidine kinase activity
EP550_15255	COG0745	RESPONSE REGULATOR receiver
EP550_15275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EP550_15285	COG2205	protein histidine kinase activity
EP550_15355	COG4993	Dehydrogenase
EP550_15385	COG0384	phenazine biosynthesis protein PhzF
EP550_15400	COG2826	transposase and inactivated derivatives, IS30 family
EP550_15420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EP550_15425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EP550_15435	COG0583	DNA-binding transcription factor activity
EP550_15455	COG1473	amidohydrolase
EP550_15465	COG0583	DNA-binding transcription factor activity
EP550_15485	COG0583	DNA-binding transcription factor activity
EP550_15490	COG1053	succinate dehydrogenase
EP550_15500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EP550_15505	COG2814	Major facilitator Superfamily
EP550_15510	COG1960	acyl-CoA dehydrogenase activity
EP550_15515	COG0583	DNA-binding transcription factor activity
EP550_15520	COG1063	alcohol dehydrogenase
EP550_15550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EP550_15555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EP550_15560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EP550_15575	COG3667	copper resistance
EP550_15580	COG2132	Multicopper oxidase
EP550_15590	COG0561	phosphatase activity
EP550_15595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EP550_15620	COG1214	PFAM Peptidase M22, glycoprotease
EP550_15665	COG4372	Transposase
EP550_15685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EP550_15695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EP550_15700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EP550_15705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EP550_15765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EP550_15775	COG1846	Transcriptional regulator
EP550_15780	COG1764	response to oxidative stress
EP550_15820	COG0037	tRNA processing
EP550_15830	COG0248	Ppx GppA phosphatase
EP550_15860	COG0072	phenylalanine-tRNA ligase activity
EP550_15885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EP550_15900	COG1238	metal cluster binding
EP550_15905	COG0625	glutathione transferase activity
EP550_15925	COG0318	PFAM AMP-dependent synthetase and ligase
EP550_15930	COG3028	Belongs to the UPF0307 family
EP550_15935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EP550_15955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EP550_15960	COG0617	tRNA 3'-terminal CCA addition
EP550_15965	COG1555	photosystem II stabilization
EP550_15970	COG3956	TIGRFAM MazG family protein
EP550_15980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EP550_16000	COG0784	Response regulator, receiver
EP550_16000	COG2205	protein histidine kinase activity
EP550_16000	COG5002	protein histidine kinase activity
EP550_16005	COG1024	Enoyl-CoA hydratase
EP550_16010	COG2084	Dehydrogenase
EP550_16015	COG3622	Belongs to the hyi family
EP550_16030	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EP550_16035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EP550_16040	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
EP550_16065	COG2814	Major facilitator Superfamily
EP550_16070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EP550_16080	COG0583	DNA-binding transcription factor activity
EP550_16090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EP550_16105	COG0084	hydrolase, TatD family'
EP550_16120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EP550_16155	COG0440	acetolactate synthase activity
EP550_16160	COG0028	Belongs to the TPP enzyme family
EP550_16185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EP550_16190	COG0577	efflux transmembrane transporter activity
EP550_16190	COG1136	(ABC) transporter
EP550_16195	COG1538	Outer membrane efflux protein
EP550_16210	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EP550_16215	COG1162	GTPase activity
EP550_16225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
EP550_16245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EP550_16250	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_16290	COG2986	histidine ammonia-lyase
EP550_16305	COG0318	PFAM AMP-dependent synthetase and ligase
EP550_16315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP550_16320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP550_16360	COG1426	Protein conserved in bacteria
EP550_16395	COG0793	Belongs to the peptidase S41A family
EP550_16410	COG2267	carboxylic ester hydrolase activity
EP550_16420	COG1012	belongs to the aldehyde dehydrogenase family
EP550_16425	COG3265	gluconokinase activity
EP550_16435	COG0800	Aldolase
EP550_16460	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EP550_16465	COG0280	phosphate acetyltransferase
EP550_16465	COG0857	belongs to the CobB CobQ family
EP550_16470	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EP550_16470	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EP550_16490	COG0740	serine-type endopeptidase activity
EP550_16500	COG4774	siderophore transport
EP550_16510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EP550_16520	COG2813	Specifically methylates the guanine in position
EP550_16520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EP550_16620	COG0788	formyltetrahydrofolate deformylase activity
EP550_16635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EP550_16640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EP550_16645	COG4651	solute:proton antiporter activity
EP550_16645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP550_16665	COG0724	RNA recognition motif
EP550_16670	COG0210	DNA helicase
EP550_16695	COG1733	regulation of RNA biosynthetic process
EP550_16715	COG1280	lysine exporter protein (LysE YggA)
EP550_16720	COG1560	Kdo2-lipid A biosynthetic process
EP550_16730	COG1301	dicarboxylic acid transport
EP550_16785	COG0473	3-isopropylmalate dehydrogenase activity
EP550_16850	COG0583	DNA-binding transcription factor activity
EP550_16865	COG0625	glutathione transferase activity
EP550_16870	COG2378	regulation of single-species biofilm formation
EP550_16875	COG0546	phosphoglycolate phosphatase activity
EP550_16890	COG1530	ribonuclease E activity
EP550_16905	COG0583	DNA-binding transcription factor activity
EP550_16910	COG4221	oxidoreductase activity
EP550_16915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EP550_16925	COG0534	Mate efflux family protein
EP550_16940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EP550_16980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EP550_16985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EP550_17000	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EP550_17010	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
EP550_17010	COG0644	oxidoreductase
EP550_17015	COG0425	Belongs to the sulfur carrier protein TusA family
EP550_17020	COG4535	Mg2 and Co2 transporter CorC
EP550_17030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EP550_17050	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EP550_17055	COG0475	glutathione-regulated potassium exporter activity
EP550_17055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EP550_17060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EP550_17070	COG0484	heat shock protein binding
EP550_17075	COG0789	Transcriptional regulator
EP550_17080	COG0598	Magnesium transport protein CorA
EP550_17100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EP550_17105	COG1074	ATP-dependent DNA helicase activity
EP550_17110	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
EP550_17130	COG2226	methyltransferase
EP550_17145	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EP550_17150	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EP550_17165	COG2111	Na H antiporter
EP550_17165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EP550_17170	COG1006	Multisubunit Na H antiporter MnhC subunit
EP550_17175	COG0651	ATP synthesis coupled electron transport
EP550_17185	COG2212	antiporter activity
EP550_17205	COG0195	Participates in both transcription termination and antitermination
EP550_17255	COG0237	dephospho-CoA kinase activity
EP550_17265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EP550_17280	COG0497	DNA recombination
EP550_17290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EP550_17320	COG2169	Transcriptional regulator
EP550_17320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EP550_17325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EP550_17395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EP550_17410	COG0326	Molecular chaperone. Has ATPase activity
EP550_17425	COG2056	Na+-H+ antiporter family
EP550_17430	COG0596	Alpha beta hydrolase
EP550_17530	COG0546	phosphoglycolate phosphatase activity
EP550_17535	COG1716	ATPase activity
EP550_17580	COG0181	hydroxymethylbilane synthase activity
EP550_17590	COG3275	phosphorelay sensor kinase activity
EP550_17610	COG1538	Outer membrane efflux protein
EP550_17615	COG0697	spore germination
EP550_17640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EP550_17645	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EP550_17650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EP550_17655	COG0772	Belongs to the SEDS family
EP550_17680	COG4974	Belongs to the 'phage' integrase family
EP550_17685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP550_17695	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EP550_17705	COG2197	response regulator
EP550_17720	COG0793	Belongs to the peptidase S41A family
EP550_17725	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EP550_17730	COG0795	lipopolysaccharide-transporting ATPase activity
EP550_17770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP550_17770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EP550_17780	COG0004	ammonium transporteR
EP550_17785	COG0347	Belongs to the P(II) protein family
EP550_17795	COG0606	chelatase, subunit chli
EP550_17850	COG0659	secondary active sulfate transmembrane transporter activity
EP550_17855	COG0589	response to stress
EP550_17895	COG0606	chelatase, subunit chli
EP550_17900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EP550_17910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EP550_17930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EP550_17945	COG0318	PFAM AMP-dependent synthetase and ligase
EP550_17955	COG0477	Major facilitator Superfamily
EP550_17960	COG2860	membrane
EP550_17965	COG3012	SEC-C Motif Domain Protein
EP550_17970	COG1253	flavin adenine dinucleotide binding
EP550_17980	COG2814	Major facilitator Superfamily
EP550_17990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EP550_18025	COG0655	NAD(P)H dehydrogenase (quinone) activity
EP550_18035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EP550_18070	COG1309	transcriptional regulator
EP550_18105	COG0758	DNA mediated transformation
EP550_18115	COG0697	spore germination
EP550_18120	COG1309	transcriptional regulator
EP550_18135	COG0386	Belongs to the glutathione peroxidase family
EP550_18205	COG1121	(ABC) transporter
EP550_18210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EP550_18215	COG1280	lysine exporter protein (LysE YggA)
EP550_18220	COG2837	iron assimilation
EP550_18225	COG0281	malic enzyme
EP550_18285	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EP550_18285	COG0519	Catalyzes the synthesis of GMP from XMP
EP550_18290	COG4399	Belongs to the UPF0754 family
EP550_18295	COG2259	Doxx family
EP550_18300	COG0586	Pfam SNARE associated Golgi protein
EP550_18315	COG1192	Involved in chromosome partitioning
EP550_18325	COG0271	Belongs to the BolA IbaG family
EP550_18360	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EP550_18360	COG3321	synthase
EP550_18360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EP550_18360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EP550_18365	COG1960	acyl-CoA dehydrogenase activity
EP550_18375	COG2197	response regulator
EP550_18385	COG3916	Acyl-homoserine-lactone synthase
EP550_18390	COG0477	Major facilitator Superfamily
EP550_18395	COG1024	Enoyl-CoA hydratase
EP550_18400	COG1024	Enoyl-CoA hydratase
EP550_18405	COG1960	acyl-CoA dehydrogenase activity
EP550_18410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EP550_18430	COG1113	amino acid transport
EP550_18435	COG1113	amino acid transport
EP550_18440	COG0251	oxidation-reduction process
EP550_18455	COG1522	sequence-specific DNA binding
EP550_18480	COG0564	pseudouridine synthase activity
EP550_18530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EP550_18545	COG1802	Transcriptional regulator
EP550_18555	COG1448	Aminotransferase
EP550_18560	COG0277	FAD linked oxidase domain protein
EP550_18570	COG2186	Transcriptional regulator
EP550_18580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EP550_18590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EP550_18605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EP550_18610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EP550_18615	COG1216	Glycosyl transferase, family 2
EP550_18635	COG0438	transferase activity, transferring glycosyl groups
EP550_18665	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
EP550_18695	COG0728	peptidoglycan biosynthetic process
EP550_18700	COG3023	N-Acetylmuramoyl-L-alanine amidase
EP550_18755	COG0546	phosphoglycolate phosphatase activity
EP550_18760	COG1028	Short-chain dehydrogenase reductase Sdr
EP550_18780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP550_18785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EP550_18790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EP550_18795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EP550_18800	COG1116	anion transmembrane transporter activity
EP550_18805	COG1309	transcriptional regulator
EP550_18810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EP550_18820	COG0196	riboflavin kinase activity
EP550_18825	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EP550_18835	COG1047	Peptidyl-prolyl cis-trans
EP550_18875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EP550_18930	COG2951	lytic endotransglycosylase activity
EP550_18935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EP550_18955	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EP550_18965	COG0671	phosphoesterase, PA-phosphatase related
EP550_18970	COG0861	Integral membrane protein TerC family
EP550_18980	COG0754	glutathionylspermidine amidase activity
EP550_18990	COG0402	S-adenosylhomocysteine deaminase activity
EP550_19010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EP550_19015	COG1230	cation diffusion facilitator family transporter
EP550_19030	COG0706	membrane insertase activity
EP550_19045	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EP550_19085	COG2826	transposase and inactivated derivatives, IS30 family
EP550_19095	COG2826	transposase and inactivated derivatives, IS30 family