locus-tag class description BL01_00190 ENOG4105K4U addiction module toxin, RelE StbE family BL01_00230 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BL01_00325 ENOG4105DFP Integrase BL01_00415 ENOG4105F8V Hydrolase, tatD family BL01_00425 ENOG4105PV3 Inner membrane protein yqiJ BL01_00440 ENOG4105E0K tonB-dependent siderophore receptor BL01_00450 ENOG4105HDD phospholipase BL01_00455 ENOG4105CZN Potassium uptake protein BL01_00465 ENOG4105C7B Threonine dehydratase BL01_00495 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) BL01_00500 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BL01_00510 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BL01_00525 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BL01_00570 ENOG4107VMU Membrane BL01_00575 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BL01_00585 ENOG4107QP7 CoA-transferase subunit A BL01_00590 ENOG4107QNJ CoA-transferase subunit B BL01_00595 ENOG4105CHU acetyl-coa acetyltransferase BL01_00600 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase BL01_00605 ENOG4105F2Z 3-oxoadipate enol-lactonase BL01_00610 ENOG4105D2S major facilitator superfamily BL01_00615 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BL01_00620 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta BL01_00625 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha BL01_00630 ENOG4105FF2 Type I DHQase BL01_00635 ENOG4106JPM 3-dehydroshikimate dehydratase BL01_00640 ENOG4105TW1 Carbohydrate-selective porin OprB BL01_00645 ENOG4105DZG Dehydrogenase BL01_00655 ENOG4105MD1 YeeE YedE family protein BL01_00670 ENOG4107HP6 Transcriptional regulator BL01_00675 ENOG4108PTX LysR family Transcriptional regulator BL01_00680 ENOG4105C1G acyl-Coa dehydrogenase BL01_00705 ENOG4105DNH Major Facilitator BL01_00720 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BL01_00740 ENOG4105FUY alpha subunit BL01_00750 ENOG4105CHR reductase BL01_00770 ENOG4105F11 amine oxidase BL01_00780 ENOG4105C26 Dehydrogenase BL01_00790 ENOG4105F2Z 3-oxoadipate enol-lactonase BL01_00795 ENOG4105CHU acetyl-coa acetyltransferase BL01_00800 ENOG4107QNJ CoA-transferase subunit B BL01_00805 ENOG4107QP7 CoA-transferase subunit A BL01_00815 ENOG4105NN7 muconolactone delta-isomerase BL01_00820 ENOG4105DTQ mandelate racemase muconate lactonizing BL01_00825 ENOG4108KB2 LysR family Transcriptional regulator BL01_00835 ENOG4107EJG GntR family transcriptional regulator BL01_00860 ENOG4105Y7M Transcriptional regulator, TetR family BL01_00895 ENOG4105C79 DNA protecting protein DprA BL01_00910 ENOG4108IND Tetr family transcriptional regulator BL01_00915 ENOG4107RTG Major Facilitator superfamily BL01_00925 ENOG4108V06 Glutathione peroxidase BL01_00965 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BL01_00990 ENOG4105FDK ABC transporter BL01_00995 ENOG4105FAV ABC, transporter BL01_01005 ENOG4105EZR dyp-type peroxidase family protein BL01_01015 ENOG4107R1I NAD-dependent malic enzyme BL01_01040 ENOG4105EUB pirin domain protein BL01_01060 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BL01_01065 ENOG4106MP8 UPF0754 membrane protein BL01_01070 ENOG4108VBZ doxx family BL01_01075 ENOG4105DQR SNARE associated Golgi BL01_01090 ENOG4107QJE Chromosome Partitioning Protein BL01_01100 ENOG4107PSF BolA-like protein BL01_01120 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BL01_01135 ENOG4105CEY Amp-dependent synthetase and ligase BL01_01150 ENOG4105C1G acyl-Coa dehydrogenase BL01_01175 ENOG4105CSH Transporter BL01_01180 ENOG4105E39 Enoyl-CoA hydratase BL01_01185 ENOG4105E39 Enoyl-CoA hydratase BL01_01190 ENOG4105C1G acyl-Coa dehydrogenase BL01_01200 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BL01_01205 ENOG4105C26 Dehydrogenase BL01_01215 ENOG4105C85 amino acid BL01_01220 ENOG4105C85 amino acid BL01_01225 ENOG4105M4H endoribonuclease L-psp BL01_01240 ENOG4105EW9 transcriptional regulator AsnC family BL01_01265 ENOG4105D3G Pseudouridine synthase BL01_01280 ENOG4108IG5 Transcriptional regulator BL01_01325 ENOG4108I0Z Aconitate hydratase BL01_01330 ENOG4105BZN citrate synthase BL01_01335 ENOG4105CR4 methylisocitrate lyase BL01_01340 ENOG4105DRR Transcriptional regulator, GntR family BL01_01345 ENOG4105CGF Aromatic amino acid aminotransferase BL01_01350 ENOG4105CXG d-lactate dehydrogenase BL01_01360 ENOG41073TP transcriptional regulator BL01_01365 ENOG4105DAA L-lactate BL01_01370 ENOG4107QKV phosphomannomutase BL01_01375 ENOG4105CMR udp-glucose 4-epimerase BL01_01385 ENOG4105C6Y Udp-glucose 6-dehydrogenase BL01_01390 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BL01_01395 ENOG4105D3Q Sugar transferase BL01_01400 ENOG4108RYC glycosyltransferase BL01_01405 ENOG4105CG5 Glycosyl transferase (Group 1 BL01_01435 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BL01_01440 ENOG4105J5G Transferase hexapeptide repeat containing protein BL01_01445 ENOG4107R5Z Oxidoreductase domain protein BL01_01450 ENOG4107QQG Dehydrogenase BL01_01455 ENOG4105DAY polysaccharide export protein BL01_01465 ENOG4105D75 Capsular exopolysaccharide family BL01_01470 ENOG4108V1T peptidylprolyl cis-trans isomerase BL01_01475 ENOG4108V1T peptidylprolyl cis-trans isomerase BL01_01480 ENOG4105CJR Integral membrane protein (MviN BL01_01485 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BL01_01490 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BL01_01500 ENOG4105HSS phospholipase C BL01_01530 ENOG41062JF Transcriptional regulator BL01_01545 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BL01_01550 ENOG4105UBK short-chain dehydrogenase reductase BL01_01565 ENOG4107QZM n-acetylglutamate synthase BL01_01570 ENOG4105GVF (ABC) transporter BL01_01575 ENOG4105GVF (ABC) transporter BL01_01580 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) BL01_01585 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BL01_01590 ENOG4108VM9 ABC, transporter BL01_01595 ENOG4108R86 Transcriptional regulator BL01_01600 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BL01_01610 ENOG4105DTN riboflavin biosynthesis protein ribF BL01_01615 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BL01_01625 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase BL01_01680 ENOG4105CNU cell division protein FtsK BL01_01685 ENOG4105C3M thioredoxin reductase BL01_01690 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) BL01_01700 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BL01_01765 ENOG4107RZC phospholipase d BL01_01785 ENOG4108IGT Dipeptidase BL01_01825 ENOG4105WQI isochorismatase BL01_01830 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BL01_01835 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) BL01_01840 ENOG4105E0C molybdate abc transporter BL01_01845 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BL01_01850 ENOG4105F4R Transcriptional regulator mode BL01_01855 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit BL01_01860 ENOG4108YS2 small subunit BL01_01865 ENOG4105F57 Anthranilate dioxygenase reductase BL01_01890 ENOG4105CHR reductase BL01_01905 ENOG4105CF7 AraC family transcriptional regulator BL01_01930 ENOG4107VGR Catalase BL01_01935 ENOG4105CPW cytochrome b561 BL01_01955 ENOG4108MXF Alpha Beta Hydrolase BL01_01960 ENOG4105MXW flavin reductase domain protein, FMN-binding BL01_01965 ENOG4108M8W Monooxygenase BL01_01970 ENOG4105C26 Dehydrogenase BL01_01980 ENOG4105ETS cytosine purines uracil thiamine allantoin BL01_01990 ENOG4105C26 Dehydrogenase BL01_01995 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BL01_02000 ENOG4105HEI LysR family (Transcriptional regulator BL01_02010 ENOG4107HP6 Transcriptional regulator BL01_02015 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase BL01_02025 ENOG4105C4Y ABC transporter BL01_02030 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BL01_02035 ENOG4107RCV ABC transporter, permease BL01_02045 ENOG4107STF Involved in phosphonate degradation (By similarity) BL01_02050 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BL01_02055 ENOG4107RGD Major Facilitator superfamily BL01_02060 ENOG4105C1G acyl-Coa dehydrogenase BL01_02080 ENOG4108UKI Enoyl-CoA hydratase BL01_02085 ENOG4105EA8 2-Nitropropane dioxygenase BL01_02090 ENOG4105EQ0 Major Facilitator superfamily BL01_02100 ENOG4105CHU acetyl-coa acetyltransferase BL01_02105 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BL01_02110 ENOG4105CHR reductase BL01_02115 ENOG4105E39 Enoyl-CoA hydratase BL01_02120 ENOG4105C1G acyl-Coa dehydrogenase BL01_02125 ENOG4107RGD Major Facilitator superfamily BL01_02130 ENOG4107QP7 CoA-transferase subunit A BL01_02135 ENOG4107QNJ CoA-transferase subunit B BL01_02145 ENOG4105EQ0 Major Facilitator superfamily BL01_02155 ENOG4105CSU acyl-Coa dehydrogenase BL01_02170 ENOG4105CC0 LysR family Transcriptional regulator BL01_02185 ENOG4105E39 Enoyl-CoA hydratase BL01_02190 ENOG4107QX3 carboxylase BL01_02195 ENOG4105C1G acyl-Coa dehydrogenase BL01_02200 ENOG4105R8C Transcriptional regulator BL01_02205 ENOG4105CEY Amp-dependent synthetase and ligase BL01_02225 ENOG4105HEI LysR family (Transcriptional regulator BL01_02275 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BL01_02295 ENOG4105KT5 UmuD protein BL01_02305 ENOG4105EW9 transcriptional regulator AsnC family BL01_02315 ENOG4105BZU Histidine kinase BL01_02320 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase BL01_02330 ENOG4105EAD ABC transporter BL01_02335 ENOG4108HW4 amino acid AbC transporter BL01_02340 ENOG4105CDA abc transporter atp-binding protein BL01_02345 ENOG4107RP9 extracellular solute-binding protein, family 3 BL01_02350 ENOG4105CT1 (ABC) transporter BL01_02355 ENOG4105EXG Transcriptional regulator BL01_02365 ENOG4105C9B Cysteine desulfurase BL01_02370 ENOG4105ESN nucleotide-binding protein BL01_02375 ENOG4105D7W serine acetyltransferase BL01_02385 ENOG4105CHR reductase BL01_02395 ENOG4105CBN LysR family transcriptional regulator BL01_02400 ENOG4105CYM Glutathione S-transferase BL01_02405 ENOG4108SHQ Glutathione S-transferase BL01_02410 ENOG4105CMU LysR family (Transcriptional regulator BL01_02415 ENOG4105VAW lrga family BL01_02420 ENOG41067MG lrgb family BL01_02440 ENOG4105DXI Major Facilitator superfamily BL01_02455 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase BL01_02460 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) BL01_02475 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase BL01_02480 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BL01_02495 ENOG4108K70 Transcriptional regulator BL01_02500 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BL01_02510 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BL01_02515 ENOG4105C4M (Ubiquinol oxidase) subunit I BL01_02535 ENOG4105C54 Major Facilitator superfamily BL01_02545 ENOG4106FTQ Taurine ABC transporter, periplasmic BL01_02550 ENOG4108IY8 ABC, transporter BL01_02555 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BL01_02560 ENOG4105E2B Taurine dioxygenase BL01_02570 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BL01_02580 ENOG4105CBN LysR family transcriptional regulator BL01_02590 ENOG4105CPN adenine deaminase BL01_02605 ENOG41082YX Transcriptional regulator, arsr family BL01_02610 ENOG4105D6J arsenicaL-resistance protein BL01_02615 ENOG4108KB2 LysR family Transcriptional regulator BL01_02630 ENOG4108JU3 Alkyl hydroperoxide reductase BL01_02655 ENOG4105C0B DNA polymerase III (alpha subunit) BL01_02670 ENOG4105CHM Aminotransferase BL01_02680 ENOG4108V06 Glutathione peroxidase BL01_02685 ENOG4105E7U AraC family transcriptional regulator BL01_02715 ENOG4105ZED uncharacterized protein ygaH BL01_02720 ENOG4108UMN azlc family BL01_02745 ENOG4105C3G gtp-binding protein BL01_02750 ENOG4108UMI ABC transporter, permease BL01_02755 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BL01_02760 ENOG4105D01 (LipO)protein BL01_02765 ENOG4105D01 (LipO)protein BL01_02780 ENOG4107T8P acyl-Coa dehydrogenase BL01_02785 ENOG4108W5M transcriptional regulator BL01_02800 ENOG4105D29 Helix-turn-helix type 11 domain protein BL01_02805 ENOG4107XGZ Hydrolase BL01_02810 ENOG4105EI2 Pseudouridine synthase BL01_02815 ENOG4105C03 ribonuclease BL01_02835 ENOG4105CBN LysR family transcriptional regulator BL01_02840 ENOG4105EMU Dehydrogenase BL01_02845 ENOG4105CSA Coproporphyrinogen iii oxidase BL01_02855 ENOG4107QI1 Mate efflux family protein BL01_02865 ENOG4107T8P acyl-Coa dehydrogenase BL01_02905 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) BL01_02910 ENOG4105C5X domain protein BL01_02925 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BL01_02935 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase BL01_02940 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BL01_02945 ENOG4108JU5 Magnesium and cobalt efflux protein BL01_02950 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BL01_02955 ENOG4108Z7R Chaperone CsaA BL01_02965 ENOG4108VAU general secretion pathway protein G BL01_02970 ENOG4105D7Q type ii secretion system BL01_02975 ENOG4105C25 Primosomal protein n' BL01_02980 ENOG4105CKD glutathione-regulated potassium-efflux system protein BL01_02985 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BL01_02995 ENOG4105DVC DnaJ domain protein BL01_03000 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) BL01_03005 ENOG4107QUT magnesium and cobalt transport protein CorA BL01_03025 ENOG4107QYX exodeoxyribonuclease v alpha BL01_03030 ENOG4107QKA exodeoxyribonuclease V beta BL01_03035 ENOG4105DSY exodeoxyribonuclease V, gamma BL01_03045 ENOG4105CSR polyphosphate kinase 2 BL01_03055 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BL01_03070 ENOG41061H0 Monooxygenase BL01_03075 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BL01_03090 ENOG4105D65 subunit l BL01_03095 ENOG4108ZE9 Monovalent cation H antiporter subunit C BL01_03100 ENOG4107R4Z monovalent cation h antiporter subunit d BL01_03105 ENOG4105SC1 monovalent cation H antiporter subunit E BL01_03110 ENOG4105W4C monovalent cation H antiporter subunit F BL01_03115 ENOG4105KJM monovalent cation h antiporter subunit g BL01_03130 ENOG4105CHV Transcription elongation factor NusA BL01_03155 ENOG4107EJC Preprotein translocase subunit SecG BL01_03165 ENOG4107QHF type ii secretion system protein e BL01_03180 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BL01_03190 ENOG4105C2N RNA methyltransferase TrmH family group 3 BL01_03205 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BL01_03215 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BL01_03245 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BL01_03250 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BL01_03320 ENOG4107ZXU DSBA oxidoreductase BL01_03335 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BL01_03350 ENOG4105D3Y Na H antiporter BL01_03355 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BL01_03405 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BL01_03410 ENOG4105PM1 preprotein translocase subunit SecE BL01_03430 ENOG4105HSS phospholipase C BL01_03440 ENOG4105C0A alcohol dehydrogenase BL01_03470 ENOG4105CBC glutamate synthase BL01_03575 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BL01_03580 ENOG4105DGW oligopeptidase A BL01_03585 ENOG4105VKU nucleicacid-binding protein BL01_03630 ENOG4105C1G acyl-Coa dehydrogenase BL01_03655 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BL01_03665 ENOG41067V7 50S ribosomal protein L36 BL01_03670 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BL01_03780 ENOG41089BK Glutamine amido-transferase BL01_03785 ENOG4105C28 cystathionine BL01_03790 ENOG4105D7A ATP-binding protein BL01_03800 ENOG4105KPV Transcriptional regulator BL01_03815 ENOG4105CK2 sodium dicarboxylate symporter BL01_03820 ENOG4105C29 acyl-CoA thioesterase BL01_03840 ENOG4105CB5 ATP-dependent DNA helicase recG BL01_03845 ENOG4105MJ2 Competence protein BL01_03855 ENOG4108URH decarboxylase BL01_03860 ENOG4105D7N magnesium and cobalt transport protein CorA BL01_03870 ENOG4105E3I toluene tolerance BL01_03880 ENOG4105CY3 ABC transporter, permease BL01_03885 ENOG4105DHJ ABC, transporter BL01_03895 ENOG4105C1J atp-dependent rna helicase BL01_03900 ENOG4105ECY inositol monophosphatase BL01_03915 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) BL01_03930 ENOG4105CSU acyl-Coa dehydrogenase BL01_03940 ENOG41067S9 phage shock protein C, PspC BL01_03945 ENOG4105W87 Cbs domain BL01_04005 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BL01_04030 ENOG4105C26 Dehydrogenase BL01_04040 ENOG4105C8Y Acetylornithine aminotransferase BL01_04045 ENOG4105D82 Glutamate dehydrogenase BL01_04055 ENOG4105C4M (Ubiquinol oxidase) subunit I BL01_04060 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BL01_04080 ENOG41068P6 UPF0319 protein BL01_04090 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BL01_04120 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BL01_04125 ENOG4105C8Y Acetylornithine aminotransferase BL01_04130 ENOG4105M2J Glutaredoxin BL01_04140 ENOG4105CC0 LysR family Transcriptional regulator BL01_04145 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BL01_04150 ENOG4105CWM branched-chain amino acid transport system II carrier protein BL01_04175 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BL01_04180 ENOG4105DE4 1-phosphofructokinase BL01_04185 ENOG4105DM4 PTS System BL01_04210 ENOG4105BZU Histidine kinase BL01_04220 ENOG4105D8V Glucose sorbosone dehydrogenase BL01_04225 ENOG4108RAV Conserved protein BL01_04230 ENOG4105CHH sulfate transporter BL01_04245 ENOG4105C85 amino acid BL01_04255 ENOG4105F7P transcriptional regulator AsnC family BL01_04280 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 BL01_04285 ENOG4105VEJ Heat shock protein BL01_04295 ENOG4105Y3E Modulates RecA activity (By similarity) BL01_04305 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BL01_04330 ENOG4105DZP Membrane-associated zinc metalloprotease BL01_04340 ENOG4105KNE Phosphatidate cytidylyltransferase BL01_04345 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BL01_04365 ENOG4105CUX Signal transduction histidine kinase BL01_04370 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BL01_04425 ENOG4105CMR udp-glucose 4-epimerase BL01_04430 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) BL01_04450 ENOG4105T38 integral membrane protein BL01_04455 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BL01_04465 ENOG4105CVM Molybdenum cofactor synthesis domain protein BL01_04470 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BL01_04485 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BL01_04505 ENOG4108IFG nitrite reductase, (NAD(P)H) BL01_04510 ENOG4107QZF nitrite reductase NADPH large subunit BL01_04520 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BL01_04540 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BL01_04545 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BL01_04555 ENOG4105D8G Major Facilitator superfamily BL01_04595 ENOG4105EAD ABC transporter BL01_04600 ENOG4105DRP amino acid AbC transporter BL01_04605 ENOG4105CDA abc transporter atp-binding protein BL01_04615 ENOG4105EW9 transcriptional regulator AsnC family BL01_04650 ENOG4105NX3 Membrane BL01_04665 ENOG4105E4F Isochorismate synthase BL01_04685 ENOG4105BZ1 (ABC) transporter BL01_04700 ENOG4105WQI isochorismatase BL01_04705 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BL01_04710 ENOG4105C0W non-ribosomal peptide synthetase BL01_04730 ENOG4108IPW abc transporter atp-binding protein BL01_04745 ENOG4105CEY Amp-dependent synthetase and ligase BL01_04760 ENOG4105WWK YheO domain protein BL01_04770 ENOG4105C2I pirin domain protein BL01_04795 ENOG4105J7D transcriptional regulator BL01_04805 ENOG4107WEA mandelate racemase muconate lactonizing BL01_04810 ENOG4107QNK )-transporter BL01_04815 ENOG41060M8 Pfam:PhdYeFM BL01_04845 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) BL01_04850 ENOG4107QZF nitrite reductase NADPH large subunit BL01_04855 ENOG4105C26 Dehydrogenase BL01_04865 ENOG4105C94 Transporter BL01_04870 ENOG4105C94 Transporter BL01_04875 ENOG4105ETT transcriptional Regulator, LysR family BL01_04880 ENOG4105C85 amino acid BL01_04885 ENOG4105C26 Dehydrogenase BL01_04900 ENOG4108K8K Transcriptional regulator BL01_04935 ENOG4105VCD cytoplasmic protein BL01_04940 ENOG4105D22 carbon starvation protein BL01_04950 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BL01_04970 ENOG4105DHU Bile acid BL01_04985 ENOG4105DAN ATP-dependent protease BL01_04990 ENOG4105EJC lysr family transcriptional regulator BL01_04995 ENOG4108K5P (LipO)protein BL01_05015 ENOG4105DZ1 carboxypeptidase BL01_05020 ENOG4108Z0R Transferase BL01_05040 ENOG4107QTF adenylosuccinate lyase BL01_05050 ENOG4105EEQ Na H antiporter BL01_05055 ENOG4105CGZ zinc metallopeptidase BL01_05060 ENOG4105CKW Inner membrane protein yedI BL01_05070 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BL01_05080 ENOG4107QN2 dihydrolipoyl dehydrogenase BL01_05085 ENOG4105C7S Dehydrogenase BL01_05090 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BL01_05095 ENOG4105E33 succinate dehydrogenase BL01_05105 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein BL01_05110 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit BL01_05150 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BL01_05155 ENOG41084BA UPF0250 protein BL01_05160 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) BL01_05175 ENOG4105CUB amino acid BL01_05185 ENOG4105KVH Transcriptional regulator BL01_05190 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BL01_05195 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BL01_05210 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) BL01_05240 ENOG410841Q phosphoesterase PA-phosphatase related protein BL01_05245 ENOG4105C1P efflux transporter, rnd family, mfp subunit BL01_05250 ENOG4105BZS acriflavin resistance protein BL01_05255 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BL01_05260 ENOG4105K8R UPF0145 protein BL01_05265 ENOG4105K8R UPF0145 protein BL01_05285 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BL01_05305 ENOG4108M0I Transcriptional regulator BL01_05320 ENOG4105DHQ Histidine kinase BL01_05325 ENOG4105XJC Two component transcriptional regulator (Winged helix family BL01_05330 ENOG4105DIJ Phosphoethanolamine transferase BL01_05355 ENOG4105D78 K07001 NTE family protein BL01_05370 ENOG4105MSB protein, conserved in bacteria BL01_05375 ENOG4105CTB Polyprenyl synthetase BL01_05380 ENOG4105C7F AcnD-accessory protein PrpF BL01_05385 ENOG4105C85 amino acid BL01_05405 ENOG4105CF7 AraC family transcriptional regulator BL01_05435 ENOG4108X0B nad(p)h dehydrogenase (quinone) BL01_05445 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein BL01_05455 ENOG4105D8T Acyltransferase BL01_05465 ENOG4105C03 ribonuclease BL01_05470 ENOG4108Z03 MAF-like protein BL01_05475 ENOG4105VQ7 Rod shape-determining protein MreD BL01_05480 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BL01_05485 ENOG4105DFF Rod shape-determining protein mreb BL01_05490 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BL01_05500 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BL01_05515 ENOG4105PNM synthesis protein BL01_05530 ENOG41080TK Universal stress protein BL01_05545 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BL01_05550 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BL01_05565 ENOG4105HBR Rna-binding protein BL01_05575 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BL01_05580 ENOG4105EEI dihydropteroate synthase BL01_05630 ENOG4105CSH Transporter BL01_05635 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BL01_05640 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BL01_05655 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BL01_05675 ENOG41080IJ Diacylglycerol kinase BL01_05685 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase BL01_05690 ENOG4105BZS acriflavin resistance protein BL01_05705 ENOG4105E4C Lytic transglycosylase catalytic BL01_05725 ENOG4108RRZ Transcription elongation factor GreB BL01_05740 ENOG4105CEY Amp-dependent synthetase and ligase BL01_05780 ENOG4105BZW Glycerate kinase BL01_05785 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit BL01_05790 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BL01_05805 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) BL01_05815 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BL01_05820 ENOG4105C85 amino acid BL01_05830 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BL01_05840 ENOG4105N14 lysine exporter protein LysE YggA BL01_05845 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BL01_05850 ENOG4105BZJ Electron transfer flavoprotein BL01_05855 ENOG4105C10 Electron transfer flavoprotein BL01_05860 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BL01_05895 ENOG4107KET secretion protein, HlyD family BL01_05925 ENOG4105D60 lipoprotein releasing system transmembrane protein BL01_05930 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BL01_05935 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BL01_05945 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BL01_05950 ENOG4107R6F Alpha Beta Hydrolase Fold protein BL01_05955 ENOG4108V3E phosphoribosylglycinamide formyltransferase BL01_05965 ENOG4105C02 permease BL01_06015 ENOG4105KCK Peptidoglycan-associated lipoprotein BL01_06020 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) BL01_06030 ENOG4105M8F Biopolymer transport protein exbD tolR BL01_06035 ENOG4105E02 MotA TolQ exbB proton channel BL01_06040 ENOG4107YD3 Thioesterase BL01_06045 ENOG4105CH2 amidohydrolase BL01_06065 ENOG4108ETH Formylglycinamide ribotide synthetase BL01_06070 ENOG4105C2C drug resistance transporter, Bcr CflA BL01_06080 ENOG4105EGD dinuclear metal center protein, YbgI family BL01_06085 ENOG4108UKI Enoyl-CoA hydratase BL01_06100 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BL01_06115 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BL01_06120 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BL01_06135 ENOG4107R11 Transcriptional regulator BL01_06140 ENOG4108IJ6 ABC transporter BL01_06150 ENOG4108I5D sulfate abc transporter BL01_06160 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BL01_06165 ENOG4105YAZ 4-amino-4-deoxychorismate lyase BL01_06170 ENOG4105HHA aminodeoxychorismate lyase BL01_06185 ENOG4108IYU L-aspartate oxidase BL01_06190 ENOG4105C0H protease BL01_06205 ENOG4105C3F Signal peptidase i BL01_06220 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BL01_06230 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) BL01_06235 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) BL01_06240 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase BL01_06245 ENOG4105EMU Dehydrogenase BL01_06280 ENOG4105BZU Histidine kinase BL01_06290 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BL01_06300 ENOG4105DTR rard protein BL01_06335 ENOG4107QS8 (LipO)protein BL01_06340 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BL01_06345 ENOG4105EA8 2-Nitropropane dioxygenase BL01_06375 ENOG4107R8N Glycosyl transferase, family 2 BL01_06390 ENOG4105CVP deoxyribo-dipyrimidine photolyase BL01_06395 ENOG4108YZY peptidylprolyl cis-trans isomerase BL01_06400 ENOG4105CEP NADH dehydrogenase BL01_06405 ENOG4105DZ1 carboxypeptidase BL01_06415 ENOG4105E9K Isocitrate dehydrogenase BL01_06420 ENOG4108R99 pseudouridine synthase BL01_06440 ENOG4105CBP Major Facilitator BL01_06445 ENOG4105EGI Transcriptional regulator BL01_06450 ENOG4108ETY sodium dicarboxylate symporter BL01_06455 ENOG4105JAB phenazine biosynthesis protein, phzf family BL01_06485 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BL01_06500 ENOG4105D3G Pseudouridine synthase BL01_06505 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) BL01_06520 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BL01_06545 ENOG4108JPW Aminotransferase BL01_06550 ENOG4105DY8 decarboxylase BL01_06560 ENOG4105F7P transcriptional regulator AsnC family BL01_06565 ENOG4107RA9 decarboxylase BL01_06570 ENOG4105C85 amino acid BL01_06575 ENOG4105CVA phosphate BL01_06580 ENOG4105C8U phosphate abc transporter BL01_06590 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BL01_06595 ENOG4105ERU peptidase BL01_06620 ENOG4105C8J )-transporter BL01_06630 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BL01_06660 ENOG4105C2W permease BL01_06670 ENOG4108IG5 Transcriptional regulator BL01_06675 ENOG4105DJY efflux transporter, rnd family, mfp subunit BL01_06710 ENOG4105F27 Major Facilitator BL01_06715 ENOG4105CV8 reductase BL01_06720 ENOG4105HEI LysR family (Transcriptional regulator BL01_06735 ENOG4105DQ4 alcohol dehydrogenase BL01_06740 ENOG4108R3E Dna-3-methyladenine glycosylase i BL01_06755 ENOG4105CEN a g-specific adenine glycosylase BL01_06775 ENOG4108ZZ3 UPF0260 protein BL01_06785 ENOG4105D1H recombination factor protein RarA BL01_06790 ENOG4105S64 Formate nitrite transporter BL01_06815 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BL01_06820 ENOG4108RWI nicotinamidase BL01_06825 ENOG4105C09 Bile acid BL01_06830 ENOG4107QI1 Mate efflux family protein BL01_06835 ENOG4105EWC Purine nucleoside phosphorylase BL01_06855 ENOG4108RXX maleylacetoacetate isomerase BL01_06865 ENOG4105C85 amino acid BL01_06875 ENOG4105CKI cobalamin synthesis protein BL01_06885 ENOG4105CZE histidine utilization repressor BL01_06890 ENOG41090B9 response to stress BL01_06905 ENOG4105C85 amino acid BL01_06915 ENOG41088SP formiminoglutamate hydrolase BL01_06930 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BL01_06935 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BL01_06945 ENOG4108ZAI phosphatidylglycerophosphatase a BL01_06950 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BL01_06965 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BL01_07000 ENOG4105KHC sulfurtransferase BL01_07030 ENOG4105BZU Histidine kinase BL01_07035 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BL01_07050 ENOG4107QJQ Mate efflux family protein BL01_07055 ENOG4105CHM Aminotransferase BL01_07060 ENOG4106BRA Membrane BL01_07075 ENOG4105D9M gamma-glutamylcysteine synthetase BL01_07085 ENOG4105CS6 Rhs element vgr protein BL01_07090 ENOG4105K4H Nlp p60 protein BL01_07105 ENOG4105IPS esterase BL01_07110 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BL01_07120 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BL01_07125 ENOG4108Z2U ureidoglycolate hydrolase BL01_07135 ENOG41061H0 Monooxygenase BL01_07150 ENOG41084YZ Hydrolase BL01_07180 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BL01_07185 ENOG4105BZU Histidine kinase BL01_07200 ENOG4105KUZ arsenate reductase BL01_07205 ENOG4105CGK Exodeoxyribonuclease III BL01_07225 ENOG4105D7Z glutathione synthase BL01_07245 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BL01_07250 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BL01_07255 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BL01_07270 ENOG41063SB peptidase BL01_07275 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BL01_07280 ENOG4107QSN dihydrolipoamide acetyltransferase BL01_07295 ENOG4105E0K tonB-dependent siderophore receptor BL01_07310 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BL01_07325 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BL01_07335 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BL01_07345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BL01_07350 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BL01_07360 ENOG4105D64 Mechanosensitive ion channel BL01_07370 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BL01_07375 ENOG4108W2Y isochorismatase BL01_07405 ENOG4105EB3 Histidine kinase BL01_07415 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL01_07425 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BL01_07435 ENOG4107EXC regulatoR BL01_07440 ENOG4105E0F Histidine kinase BL01_07450 ENOG4105BZU Histidine kinase BL01_07470 ENOG4105GKE subunit e BL01_07475 ENOG4107QIZ NADH dehydrogenase BL01_07480 ENOG4108IEH NADH dehydrogenase subunit g BL01_07495 ENOG4107UFS subunit j BL01_07505 ENOG4105D65 subunit l BL01_07510 ENOG4105C8S subunit m BL01_07530 ENOG4105DUM transcriptional regulator, lysR family BL01_07535 ENOG4105DP0 ferredoxin-NADP reductase BL01_07560 ENOG4105CBX hi0933 family BL01_07565 ENOG4105K6H D-cysteine desulfhydrase BL01_07595 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BL01_07605 ENOG4105D1F ATP-binding protein BL01_07655 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) BL01_07665 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BL01_07680 ENOG4105HF0 Membrane BL01_07690 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BL01_07710 ENOG4106UW1 Major Facilitator superfamily BL01_07715 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase BL01_07720 ENOG4108K4C ec 3.1.3.12 BL01_07725 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BL01_07735 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BL01_07740 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BL01_07750 ENOG4105FE9 pseudouridine synthase BL01_07755 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BL01_07760 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BL01_07765 ENOG4107RTD sua5 ycio yrdc ywlc family protein BL01_07770 ENOG4108BPE -transporting atpase BL01_07775 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BL01_07785 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BL01_07790 ENOG4105CHR reductase BL01_07800 ENOG4109066 lysm domain bon superfamily protein BL01_07805 ENOG4105DWF phosphomethylpyrimidine kinase BL01_07815 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BL01_07845 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BL01_07875 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) BL01_07890 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BL01_07895 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BL01_07900 ENOG4105C34 Pseudouridine synthase BL01_07905 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BL01_07925 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BL01_07940 ENOG4105EJC lysr family transcriptional regulator BL01_07945 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BL01_07950 ENOG4105C94 Transporter BL01_07960 ENOG4105DVW rieske (2Fe-2S) BL01_07965 ENOG4105C26 Dehydrogenase BL01_07970 ENOG4105E3J oxidoreductase BL01_07985 ENOG4105C4K Nad synthetase BL01_07995 ENOG4105EUB pirin domain protein BL01_08000 ENOG4108YXA Membrane BL01_08035 ENOG4108M0I Transcriptional regulator BL01_08045 ENOG4107QNJ CoA-transferase subunit B BL01_08050 ENOG4105CRW Short chain fatty acid transporter BL01_08055 ENOG4105CHU acetyl-coa acetyltransferase BL01_08065 ENOG4107YNJ LysR family Transcriptional regulator BL01_08080 ENOG4108IJ0 Aspartate ammonia-lyase BL01_08090 ENOG4105CSH Transporter BL01_08110 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BL01_08115 ENOG4106FTQ Taurine ABC transporter, periplasmic BL01_08130 ENOG4105FDP GntR family transcriptional regulator BL01_08140 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BL01_08145 ENOG4105KVH Transcriptional regulator BL01_08150 ENOG4105UEI Transcriptional Regulator AraC Family BL01_08165 ENOG4108VCT Sulfite exporter TauE/SafE BL01_08175 ENOG4107QPB Beta-lactamase domain protein BL01_08185 ENOG4105FFC UPF0187 protein BL01_08195 ENOG4105CHR reductase BL01_08210 ENOG4105CPP Dehydrogenase, E1 component BL01_08215 ENOG4107R0V Pyruvate dehydrogenase BL01_08220 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BL01_08235 ENOG4105BZU Histidine kinase BL01_08245 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BL01_08250 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BL01_08295 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BL01_08310 ENOG4105C28 cystathionine BL01_08320 ENOG4105F2W methyltransferase BL01_08350 ENOG4105K59 histidine triad (HIT) protein BL01_08375 ENOG4107QWP ABC-2 type transporter BL01_08380 ENOG4107QWP ABC-2 type transporter BL01_08385 ENOG4105CJ1 ABC, transporter BL01_08400 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BL01_08405 ENOG4105CNM Receptor BL01_08425 ENOG4107TSN permease BL01_08430 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BL01_08450 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BL01_08455 ENOG4108YZT Adenosylcobinamide kinase BL01_08470 ENOG4107VXZ Hydrolase BL01_08510 ENOG4105DJU Siderophore biosynthesis protein BL01_08515 ENOG4105DUU IucA IucC family protein BL01_08535 ENOG4108Z66 YbaK ebsC protein BL01_08550 ENOG4105C1G acyl-Coa dehydrogenase BL01_08555 ENOG4105C1G acyl-Coa dehydrogenase BL01_08560 ENOG4105EEF Alkane 1-monooxygenase BL01_08565 ENOG4105E7U AraC family transcriptional regulator BL01_08570 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BL01_08575 ENOG4105K70 DNA-binding protein BL01_08590 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BL01_08600 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BL01_08605 ENOG4108Z4V iron-sulfur cluster assembly BL01_08620 ENOG4108ZIT Ferredoxin, 2FE-2S BL01_08625 ENOG4105F8J Adenylate Guanylate cyclase BL01_08635 ENOG4108JA2 transcriptioN-repair coupling factor BL01_08655 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) BL01_08660 ENOG4105K4T epimerase BL01_08675 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BL01_08695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BL01_08705 ENOG4105DGW oligopeptidase A BL01_08720 ENOG4105EUJ GTP cyclohydrolase i BL01_08730 ENOG4105C7W Xanthine dehydrogenase BL01_08760 ENOG4105CD8 aminopeptidase N BL01_08765 ENOG4105DDQ anthranilate synthase BL01_08775 ENOG4105DUX Transporter BL01_08780 ENOG4105C5F glutamine synthetase BL01_08790 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) BL01_08825 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BL01_08830 ENOG4107QNR UPF0135 protein BL01_08835 ENOG4105C0H protease BL01_08845 ENOG4105C6K Malic enzyme BL01_08850 ENOG4105BZU Histidine kinase BL01_08855 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BL01_08860 ENOG4105SYT Methylenetetrahydrofolate reductase BL01_08865 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) BL01_08880 ENOG4107QPN acyl-Coa dehydrogenase BL01_08885 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BL01_08890 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BL01_08905 ENOG4107RNU major facilitator superfamily MFS_1 BL01_08915 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BL01_08920 ENOG4105CE9 30S ribosomal protein S2 BL01_08960 ENOG4105CVE Lytic murein transglycosylase BL01_08965 ENOG4105CNI cell division protein FtsW BL01_08980 ENOG4105E3A (ABC) transporter BL01_08985 ENOG4105DA5 (ABC) transporter BL01_09020 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BL01_09030 ENOG4105ENT Efflux transporter rnd family, mfp subunit BL01_09045 ENOG4105E89 ABC transporter BL01_09050 ENOG4105DSP amino acid AbC transporter BL01_09055 ENOG4106YG3 ABC transporter BL01_09060 ENOG4108JEH abc transporter atp-binding protein BL01_09070 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BL01_09075 ENOG4105CFP Peptidase U32 BL01_09080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BL01_09085 ENOG4105JAB phenazine biosynthesis protein, phzf family BL01_09090 ENOG4105DP0 ferredoxin-NADP reductase BL01_09095 ENOG4108R96 Methyltransferase, YaeB family BL01_09105 ENOG4107QHF type ii secretion system protein e BL01_09115 ENOG4105XJC Two component transcriptional regulator (Winged helix family BL01_09120 ENOG4105DHQ Histidine kinase BL01_09130 ENOG4105M6F mutator MutT protein BL01_09140 ENOG4105BZ4 penicillin-binding protein BL01_09145 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BL01_09150 ENOG4105VUT cytoplasmic protein BL01_09155 ENOG4107QYG anthranilate phosphoribosyltransferase BL01_09160 ENOG4105CK2 sodium dicarboxylate symporter BL01_09165 ENOG4105C1G acyl-Coa dehydrogenase BL01_09170 ENOG4105NIV Esterase BL01_09175 ENOG4105CQC Prephenate dehydratase BL01_09180 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BL01_09190 ENOG4105CIN aminoacyl-histidine dipeptidase BL01_09195 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BL01_09225 ENOG4105M08 Membrane BL01_09230 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BL01_09240 ENOG4105VEQ Cold shock protein BL01_09245 ENOG4105C1J atp-dependent rna helicase BL01_09255 ENOG41069NU Nitroreductase BL01_09290 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BL01_09305 ENOG4105C5I Dehydrogenase BL01_09310 ENOG4105ERG peptidase m48, ste24p BL01_09315 ENOG4105KTH gatB Yqey BL01_09320 ENOG4105VCC 30S ribosomal protein S21 BL01_09345 ENOG4105D9P serine threonine protein kinase BL01_09370 ENOG4105EVZ LysR family transcriptional regulator BL01_09375 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BL01_09380 ENOG4105C26 Dehydrogenase BL01_09415 ENOG4105H4F exported protein BL01_09445 ENOG4105D6U Sodium Glutamate Symporter BL01_09455 ENOG4105JXH GntR family transcriptional regulator BL01_09480 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BL01_09580 ENOG4105FBW Monooxygenase BL01_09585 ENOG4108UZX fmn reductase BL01_09600 ENOG4105BZU Histidine kinase BL01_09605 ENOG41062QD Membrane BL01_09610 ENOG4107QN1 sodium solute BL01_09620 ENOG4105C94 Transporter BL01_09630 ENOG4105BZU Histidine kinase BL01_09640 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BL01_09645 ENOG4108WUH Transcriptional regulator, TetR family BL01_09650 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BL01_09660 ENOG4105RA2 Membrane BL01_09665 ENOG4105DWF phosphomethylpyrimidine kinase BL01_09675 ENOG4107RDB Major Facilitator BL01_09680 ENOG4108UUM single-stranded DNA-binding protein BL01_09690 ENOG4108UMN azlc family BL01_09700 ENOG4105C85 amino acid BL01_09710 ENOG4108JPW Aminotransferase BL01_09715 ENOG4105C26 Dehydrogenase BL01_09725 ENOG4105CHJ isochorismatase hydrolase BL01_09730 ENOG4105EUB pirin domain protein BL01_09755 ENOG4105D94 Major Facilitator Superfamily BL01_09760 ENOG4106NZI LysR family Transcriptional regulator BL01_09780 ENOG4105CPC Aldo Keto reductase BL01_09785 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) BL01_09820 ENOG4105KVH Transcriptional regulator BL01_09825 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BL01_09890 ENOG4105CUV Homoserine Kinase BL01_09905 ENOG41061CK Antibiotic biosynthesis monooxygenase BL01_09935 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BL01_09965 ENOG4105CYC Transferase BL01_09970 ENOG4105E0F Histidine kinase BL01_09975 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BL01_09985 ENOG4105CHH sulfate transporter BL01_09990 ENOG4105PDP Short chain dehydrogenase BL01_10000 ENOG4105C5H ABC transporter BL01_10090 ENOG4108IQI permease BL01_10120 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BL01_10135 ENOG4105CJN penicillin-binding protein BL01_10140 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BL01_10145 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BL01_10160 ENOG4105DHI Methyltransferase BL01_10165 ENOG4108JQC penicillin-binding protein 1A BL01_10190 ENOG4105E4G Type IV pilus BL01_10210 ENOG4105CBC glutamate synthase BL01_10215 ENOG4105BZ8 glutamate synthase BL01_10225 ENOG4108V0P LemA family BL01_10230 ENOG4105HA9 of methanol dehydrogenase type BL01_10250 ENOG4108YSG O-Antigen polymerase BL01_10255 ENOG4108UQY Iron-storage protein BL01_10265 ENOG4105KME endoribonuclease L-psp BL01_10270 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BL01_10280 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BL01_10330 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BL01_10345 ENOG4107IFA Lipase (EC 3.1.1.3) BL01_10350 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) BL01_10355 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BL01_10380 ENOG4108JQ1 Dehydrogenase BL01_10385 ENOG4105CQB FAD linked oxidase domain protein BL01_10395 ENOG4105VRH Antibiotic biosynthesis monooxygenase BL01_10400 ENOG4105NF4 modulator of drug activity BL01_10410 ENOG4107QF7 multi-drug BL01_10415 ENOG4105EM2 membrane BL01_10420 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BL01_10425 ENOG4105IPI Membrane BL01_10430 ENOG4107SKI cobyrinic Acid a,c-diamide synthase BL01_10465 ENOG4108VX5 3-methyladenine DNA glycosylase BL01_10475 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BL01_10495 ENOG4105C2W permease BL01_10505 ENOG4108IQI permease BL01_10510 ENOG4105E0Y RtcB Protein BL01_10520 ENOG4108WHA ompa motb domain protein BL01_10530 ENOG4105CHU acetyl-coa acetyltransferase BL01_10540 ENOG410814C multidrug resistance protein BL01_10550 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BL01_10555 ENOG4105DZG Dehydrogenase BL01_10560 ENOG4105TW1 Carbohydrate-selective porin OprB BL01_10570 ENOG4108R6W Transcriptional regulator, ARAC family BL01_10575 ENOG4105CHU acetyl-coa acetyltransferase BL01_10605 ENOG4108UT2 hemolysin iii BL01_10610 ENOG4105CSH Transporter BL01_10625 ENOG4105D3R alkyl hydroperoxide reductase BL01_10645 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BL01_10680 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BL01_10695 ENOG4108WBT adenosyltransferase BL01_10715 ENOG4105CNG UPF0061 protein BL01_10720 ENOG4105E3W Two component transcriptional regulator (Winged helix family BL01_10725 ENOG4105EB3 Histidine kinase BL01_10735 ENOG4105CSU acyl-Coa dehydrogenase BL01_10740 ENOG4105CSU acyl-Coa dehydrogenase BL01_10745 ENOG4108R4R Iron-regulated virulence regulatory protein BL01_10750 ENOG4108K3A Glutathione S-transferase BL01_10755 ENOG4108VY7 phosphate-starvation-inducible protein PsiE BL01_10775 ENOG4105UGU tonB-dependent Receptor BL01_10815 ENOG4108PQP glycosyl transferase group 1 BL01_10825 ENOG4107BJW polysaccharide deacetylase BL01_10840 ENOG4105CM2 brancheD-chain amino acid aminotransferase BL01_10845 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BL01_10850 ENOG4105BZU Histidine kinase BL01_10880 ENOG4105VIE preprotein translocase, subunit YajC BL01_10885 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BL01_10890 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BL01_10895 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BL01_10905 ENOG4105FFC UPF0187 protein BL01_10910 ENOG4105DB7 PHP domain protein BL01_10920 ENOG4105K9H YciI-like protein BL01_10950 ENOG4105NAU thioesterase Superfamily protein BL01_10960 ENOG4107U2T alpha beta BL01_10965 ENOG4107QPB Beta-lactamase domain protein BL01_10975 ENOG4107QN2 dihydrolipoyl dehydrogenase BL01_11000 ENOG4108Z0R Transferase BL01_11005 ENOG41072GX Peptidase M22 Glycoprotease BL01_11030 ENOG4105DJV ribulose-phosphate 3-epimerase BL01_11035 ENOG4108HCJ Hydrolase BL01_11045 ENOG4105E3B Multicopper oxidase BL01_11050 ENOG4105VR0 copper resistance BL01_11065 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BL01_11070 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BL01_11075 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BL01_11110 ENOG4105ETT transcriptional Regulator, LysR family BL01_11115 ENOG4105C1G acyl-Coa dehydrogenase BL01_11120 ENOG4107RGD Major Facilitator superfamily BL01_11125 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BL01_11135 ENOG4107EFR Flavocytochrome c BL01_11140 ENOG4106P55 Transcriptional regulator BL01_11155 ENOG4106P55 Transcriptional regulator BL01_11165 ENOG4105CH2 amidohydrolase BL01_11185 ENOG4105ETT transcriptional Regulator, LysR family BL01_11195 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BL01_11200 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) BL01_11230 ENOG4105JAB phenazine biosynthesis protein, phzf family BL01_11245 ENOG4105C54 Major Facilitator superfamily BL01_11250 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BL01_11260 ENOG4108SF5 RNA Polymerase BL01_11290 ENOG4108YNN Heme oxygenase BL01_11315 ENOG4105D5Q Arginine ornithine antiporter BL01_11320 ENOG4107QK5 Homocysteine s-methyltransferase BL01_11350 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BL01_11355 ENOG4105C94 Transporter BL01_11360 ENOG4105C94 Transporter BL01_11380 ENOG4105CKI cobalamin synthesis protein BL01_11390 ENOG4108VWS Yaeq family BL01_11400 ENOG4107BJW polysaccharide deacetylase BL01_11405 ENOG4105CND Glycosyl transferase, family 2 BL01_11415 ENOG4106YT9 Enoyl-CoA hydratase BL01_11430 ENOG41069M3 Transcriptional regulator BL01_11450 ENOG4105CHR reductase BL01_11460 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase BL01_11465 ENOG4105DJB Major Facilitator Superfamily BL01_11475 ENOG4108MXF Alpha Beta Hydrolase BL01_11480 ENOG4105CHR reductase BL01_11495 ENOG4105C7K acetolactate synthase BL01_11505 ENOG4105CSH Transporter BL01_11515 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BL01_11520 ENOG4105CSV Glutaminase BL01_11525 ENOG4108R6W Transcriptional regulator, ARAC family BL01_11530 ENOG4105EU0 Major facilitator Superfamily BL01_11535 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BL01_11545 ENOG4108PZW LysR family Transcriptional regulator BL01_11555 ENOG4105CSP Major Facilitator Superfamily BL01_11570 ENOG4105C3R Methionine synthase BL01_11575 ENOG4105CJ3 phosphate transporter BL01_11595 ENOG4105E6M Sulphatase-modifying factor protein BL01_11600 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) BL01_11615 ENOG4107RNH Outer membrane receptor FepA BL01_11635 ENOG4108UJV acyl-CoA thioesterase i BL01_11640 ENOG4108I0Y (ABC) transporter BL01_11645 ENOG4105CV6 ABC transporter, permease BL01_11650 ENOG4107U91 Rhomboid family BL01_11670 ENOG4105C5Q Transcriptional regulator BL01_11680 ENOG4107QZF nitrite reductase NADPH large subunit BL01_11685 ENOG4105VCQ rubredoxin BL01_11705 ENOG4108MRJ BL01_11720 ENOG4107QMS site-determining protein BL01_11735 ENOG4106HNH Acyl-transferase BL01_11740 ENOG4108ZG0 Ompa motb domain protein BL01_11745 ENOG4105C4R Atp-dependent dna helicase BL01_11755 ENOG4107QKV phosphomannomutase BL01_11770 ENOG4105E7A Glutamine amidotransferase BL01_11795 ENOG41090R7 Ferric uptake BL01_11800 ENOG4105CZX twitching motility protein BL01_11805 ENOG4105CZX twitching motility protein BL01_11810 ENOG4105DFA alanine racemase domain protein BL01_11820 ENOG4105EYH Exonuclease BL01_11825 ENOG4107RH8 nuclease SbcCD subunit D BL01_11845 ENOG4105ECP epimerase BL01_11850 ENOG4105MWK D-amino acid dehydrogenase, small subunit BL01_11855 ENOG4105D52 delta-aminolevulinic acid dehydratase BL01_11860 ENOG4108VUY thioesterase Superfamily protein BL01_11865 ENOG4105CW7 secretion protein, HlyD family BL01_11870 ENOG4105C0R drug resistance transporter emrb qaca subfamily BL01_11875 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BL01_11945 ENOG41083X2 DNA polymerase III, epsilon subunit BL01_12205 ENOG4105SG9 biopolymer transport protein, ExbD BL01_12215 ENOG4107QP3 malate synthase g BL01_12220 ENOG4105D6Z AFG1 family ATPase BL01_12230 ENOG4107RN6 Monooxygenase BL01_12250 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BL01_12255 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BL01_12270 ENOG4108Z6B deaminase BL01_12290 ENOG4108RTD type II secretion system protein K BL01_12315 ENOG4105F8V Hydrolase, tatD family BL01_12325 ENOG4107QRG dna polymerase iii BL01_12335 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BL01_12340 ENOG4105BZ1 (ABC) transporter BL01_12355 ENOG4105FA0 parb-like partition protein BL01_12360 ENOG4107QJE Chromosome Partitioning Protein BL01_12370 ENOG4108S0S Nucleotidyl transferase BL01_12375 ENOG4105EHM Aminoglycoside phosphotransferase BL01_12380 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BL01_12385 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) BL01_12390 ENOG4105D2N Aldolase BL01_12410 ENOG4108UHJ MAF-like protein BL01_12415 ENOG4105EZE Cupin 4 family protein BL01_12425 ENOG41080HT Transcriptional regulator, arsr family BL01_12440 ENOG4105CJP fad dependent oxidoreductase BL01_12460 ENOG4105CT3 Monooxygenase BL01_12470 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BL01_12475 ENOG4105BZS acriflavin resistance protein BL01_12480 ENOG4105C1P efflux transporter, rnd family, mfp subunit BL01_12485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BL01_12490 ENOG4105E0F Histidine kinase BL01_12495 ENOG4108821 RND type efflux pump BL01_12500 ENOG4108R6W Transcriptional regulator, ARAC family BL01_12515 ENOG4108BAS reductase BL01_12570 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) BL01_12615 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BL01_12620 ENOG4108UMI ABC transporter, permease BL01_12625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BL01_12635 ENOG4105C12 Phosphoribosylglycinamide synthetase BL01_12640 ENOG4105DC1 bifunctional purine biosynthesis protein purh BL01_12645 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) BL01_12700 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BL01_12705 ENOG4105CDU Replicative dna helicase BL01_12730 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) BL01_12735 ENOG4105CCU oxidase (Subunit III) BL01_12740 ENOG4105BZ9 Cytochrome C oxidase, subunit I BL01_12745 ENOG4105E2S oxidase) subunit II BL01_12765 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BL01_12770 ENOG4108DNC Involved in acetate metabolism (By similarity) BL01_12775 ENOG4107GFK fumarate BL01_12795 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BL01_12805 ENOG4108ESX Receptor BL01_12815 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BL01_12825 ENOG4105DWV Homoserine O-trans-acetylase BL01_12925 ENOG4105CIY formyltetrahydrofolate deformylase BL01_12935 ENOG4107RGH Aldehyde dehydrogenase BL01_12940 ENOG4105KDC 50s ribosomal protein l28 BL01_12945 ENOG4105W0E 50S ribosomal protein L33 BL01_12950 ENOG4105CKD glutathione-regulated potassium-efflux system protein BL01_12970 ENOG4105VFU Rna-binding protein BL01_12975 ENOG4105C4R Atp-dependent dna helicase BL01_12990 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BL01_13000 ENOG4105KVH Transcriptional regulator BL01_13010 ENOG41069P5 Protein slyX homolog BL01_13015 ENOG4105C5H ABC transporter BL01_13020 ENOG4105N14 lysine exporter protein LysE YggA BL01_13025 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase BL01_13035 ENOG4105CK2 sodium dicarboxylate symporter BL01_13090 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BL01_13115 ENOG4105DUM transcriptional regulator, lysR family BL01_13140 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase BL01_13160 ENOG4105WPN DNA integration recombination invertion protein BL01_13175 ENOG4105DJ2 Major Facilitator Superfamily BL01_13180 ENOG4107Y2X deaminase BL01_13190 ENOG4105EMY transcriptional regulator BL01_13220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BL01_13230 ENOG4105UYK outer membrane protein a BL01_13300 ENOG4108HW3 (ABC) transporter BL01_13310 ENOG4105MRR Transcriptional regulator (By similarity) BL01_13330 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF BL01_13335 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BL01_13350 ENOG4105E2A Dehydrogenase BL01_13360 ENOG4105R8C Transcriptional regulator BL01_13385 ENOG4107R4J Chloride channel BL01_13390 ENOG4108JIK carboxylase BL01_13410 ENOG4105C5A transporter BL01_13415 ENOG4108WAV Transcriptional regulator BL01_13430 ENOG4105CNA YD repeat protein BL01_13460 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) BL01_13480 ENOG4105D2S major facilitator superfamily BL01_13490 ENOG4105D1S lipid A biosynthesis BL01_13495 ENOG4105BZU Histidine kinase BL01_13500 ENOG4107AQZ Membrane BL01_13525 ENOG4108Z4U Ferredoxin BL01_13565 ENOG4105DFG type I secretion outer membrane protein BL01_13570 ENOG4108IUZ ABC transporter BL01_13575 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BL01_13585 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase BL01_13590 ENOG4105C2X Arabinose 5-phosphate isomerase BL01_13625 ENOG4107YPT transcriptional regulator BL01_13655 ENOG4105II7 pyrroline-5-carboxylate reductase BL01_13665 ENOG4105VEQ Cold shock protein BL01_13670 ENOG410829K Lysine exporter protein (Lyse ygga) BL01_13705 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BL01_13755 ENOG4108KB2 LysR family Transcriptional regulator BL01_13760 ENOG4105FUY alpha subunit BL01_13765 ENOG4108UKV benzoate 1,2-dioxygenase BL01_13770 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein BL01_13775 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase BL01_13780 ENOG4105DKK Benzoate BL01_13785 ENOG4105D2S major facilitator superfamily BL01_13800 ENOG4105CQ7 ATP-dependent helicase BL01_13805 ENOG4105D3R alkyl hydroperoxide reductase BL01_13815 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) BL01_13825 ENOG4108JU3 Alkyl hydroperoxide reductase BL01_13835 ENOG4108K3A Glutathione S-transferase BL01_13845 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BL01_13850 ENOG4108TGY Glutathione S-transferase BL01_13860 ENOG4108ZG0 Ompa motb domain protein BL01_13865 ENOG4105CD3 dihydroorotase BL01_13895 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BL01_13910 ENOG4108UKZ OsmC family BL01_13950 ENOG4105C7B Threonine dehydratase BL01_13955 ENOG4105D78 K07001 NTE family protein BL01_13960 ENOG4105BZG amino acid carrier protein BL01_13980 ENOG4105C2C drug resistance transporter, Bcr CflA BL01_13985 ENOG4105EM2 membrane BL01_13995 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BL01_14035 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BL01_14040 ENOG4105WD1 Membrane BL01_14050 ENOG4106HKS Entericidin EcnA/B family BL01_14065 ENOG4105CBS Chea signal transduction histidine kinase BL01_14070 ENOG4105C8Q Methyl-accepting chemotaxis BL01_14075 ENOG4108ZGA chew protein BL01_14080 ENOG4105M3Z response regulator BL01_14085 ENOG4108UNF response regulator BL01_14110 ENOG4105KWI UPF0339 protein BL01_14115 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BL01_14120 ENOG4105K78 MarR family Transcriptional regulator BL01_14130 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) BL01_14135 ENOG4105T95 Thiol disulfide interChange protein BL01_14145 ENOG4108N2Y auxin Efflux BL01_14150 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BL01_14170 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BL01_14180 ENOG4105D82 Glutamate dehydrogenase BL01_14185 ENOG4108R3D Electron transport complex BL01_14190 ENOG4105CSM endonuclease III BL01_14215 ENOG4105CJN penicillin-binding protein BL01_14220 ENOG4106H78 methyltransferase BL01_14235 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) BL01_14245 ENOG4105CQM Urea amidohydrolase subunit alpha BL01_14280 ENOG4107RET Isocitrate lyase BL01_14290 ENOG4105C37 (CBS) domain BL01_14300 ENOG4105D4T Citrate transporter BL01_14315 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) BL01_14355 ENOG4105CHR reductase BL01_14360 ENOG4105CHU acetyl-coa acetyltransferase BL01_14370 ENOG4105C5Q Transcriptional regulator BL01_14375 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BL01_14380 ENOG4108NIW Leucine export protein LeuE BL01_14385 ENOG4105EW9 transcriptional regulator AsnC family BL01_14390 ENOG4105DKK Benzoate BL01_14400 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic BL01_14420 ENOG41081QV Universal stress protein BL01_14425 ENOG4105C5H ABC transporter BL01_14445 ENOG4105CNM Receptor BL01_14485 ENOG4107RAQ aminopeptidase BL01_14490 ENOG4105D0A hydroxylase BL01_14495 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BL01_14515 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BL01_14520 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) BL01_14530 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BL01_14540 ENOG4105W4M Transport-associated protein BL01_14550 ENOG4105E09 nadh pyrophosphatase BL01_14560 ENOG4107RZZ dna polymerase iii epsilon subunit BL01_14565 ENOG4105E9H Lytic Murein transglycosylase BL01_14565 ENOG4105E9H Lytic Murein transglycosylase BL01_14575 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component BL01_14580 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component BL01_14585 ENOG4108JQ5 ABC transporter BL01_14605 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BL01_14625 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BL01_14840 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BL01_14900 ENOG4105CVE Lytic murein transglycosylase BL01_14905 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BL01_14910 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BL01_14925 ENOG4105DFU Cell wall formation (By similarity) BL01_14935 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BL01_14940 ENOG4105DU1 integral membrane protein, terc BL01_14950 ENOG4106032 Glutathionylspermidine synthase BL01_14960 ENOG4107QUY Guanine deaminase BL01_14970 ENOG4108UGV hypoxanthine phosphoribosyltransferase BL01_14980 ENOG4105T95 Thiol disulfide interChange protein BL01_14985 ENOG4105PGM cation diffusion facilitator family transporter BL01_15000 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BL01_15015 ENOG4105VG0 50S ribosomal protein l34 BL01_15025 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BL01_15035 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BL01_15045 ENOG4105DQR SNARE associated Golgi BL01_15050 ENOG4105C5H ABC transporter BL01_15055 ENOG4108821 RND type efflux pump BL01_15060 ENOG4108821 RND type efflux pump BL01_15065 ENOG4108821 RND type efflux pump BL01_15075 ENOG4105D74 hydrolase BL01_15080 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BL01_15085 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BL01_15525 ENOG4105F95 Monooxygenase BL01_15535 ENOG4105C7N Xanthine uracil vitamin C permease BL01_15540 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) BL01_15545 ENOG4105CPW cytochrome b561 BL01_15555 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BL01_15565 ENOG4105CFH Aspartokinase BL01_15575 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BL01_15585 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BL01_15600 ENOG4105CPC Aldo Keto reductase BL01_15610 ENOG4108KHX Diguanylate cyclase BL01_15615 ENOG4105UYK outer membrane protein a BL01_15625 ENOG4107RZC phospholipase d BL01_15635 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BL01_15655 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BL01_15660 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BL01_15665 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BL01_15675 ENOG4108UJD 30S ribosomal protein S9 BL01_15680 ENOG4107MKT Stringent starvation protein a BL01_15685 ENOG4105KB2 stringent starvation protein b BL01_15705 ENOG4105C1G acyl-Coa dehydrogenase BL01_15710 ENOG4107QX3 carboxylase BL01_15725 ENOG4108RZE Tetr family transcriptional regulator BL01_15730 ENOG4105C1G acyl-Coa dehydrogenase BL01_15765 ENOG4105CC0 LysR family Transcriptional regulator BL01_15775 ENOG4105ETS cytosine purines uracil thiamine allantoin BL01_15785 ENOG4108IPJ Membrane BL01_15800 ENOG4105C6T cysteine synthase BL01_15810 ENOG4105CS1 NAD(P)H quinone oxidoreductase BL01_15830 ENOG4105CCT upf0313 protein BL01_15845 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BL01_15860 ENOG4108URH decarboxylase BL01_15865 ENOG4105EE5 Membrane protein terC BL01_15875 ENOG4105EN6 Membrane BL01_15880 ENOG41079KZ Major Facilitator Superfamily BL01_15885 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BL01_15890 ENOG4105CEY Amp-dependent synthetase and ligase BL01_15905 ENOG4105F0N pyrophosphate phospho-hydrolase BL01_15910 ENOG4105EPF Outer membrane porin BL01_15920 ENOG4108UAJ Transcriptional regulator BL01_16000 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BL01_16020 ENOG4105E0A ABC, transporter BL01_16025 ENOG4105EHG Permease protein BL01_16035 ENOG4105DQ4 alcohol dehydrogenase BL01_16050 ENOG4105CF7 AraC family transcriptional regulator BL01_16055 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BL01_16065 ENOG4105EXW epimerase dehydratase BL01_16070 ENOG4105DDW LysR family Transcriptional regulator BL01_16080 ENOG4105C01 Dihydroxy-acid dehydratase BL01_16085 ENOG4105CZJ Aldehyde dehydrogenase BL01_16105 ENOG4105C1G acyl-Coa dehydrogenase BL01_16110 ENOG4105CHR reductase BL01_16115 ENOG4108JU7 Transcriptional regulator BL01_16125 ENOG41062QD Membrane BL01_16140 ENOG4107RGH Aldehyde dehydrogenase BL01_16155 ENOG4105CH6 catalase BL01_16180 ENOG4105K56 Transcriptional regulator BL01_16185 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BL01_16195 ENOG4105NAE bifunctional deaminase-reductase domain protein BL01_16225 ENOG4107Z3H Transcriptional regulator, TetR family BL01_16235 ENOG4105CHJ isochorismatase hydrolase BL01_16240 ENOG4105EJC lysr family transcriptional regulator BL01_16245 ENOG4105D8V Glucose sorbosone dehydrogenase BL01_16250 ENOG4105CKD glutathione-regulated potassium-efflux system protein BL01_16260 ENOG4105CH2 amidohydrolase BL01_16270 ENOG4105D5K Hemolysin activator protein BL01_16275 ENOG4105CKT filamentous hemagglutinin BL01_16310 ENOG4105FDP GntR family transcriptional regulator BL01_16325 ENOG4106KR7 LysR family Transcriptional regulator BL01_16350 ENOG4108JQ1 Dehydrogenase BL01_16355 ENOG4105JSC dimethylmenaquinone methyltransferase BL01_16385 ENOG4105CD8 aminopeptidase N BL01_16405 ENOG4105F4I Transcriptional regulator BL01_16415 ENOG4107QUV Domain protein BL01_16420 ENOG4105C0A alcohol dehydrogenase BL01_16430 ENOG4107RR1 TRANSCRIPTIONal BL01_16440 ENOG4107R55 ethanolamine transporter BL01_16445 ENOG4105CPD ethanolamine ammonia-lyase BL01_16450 ENOG4107FQ9 ethanolamine ammonia-lyase BL01_16455 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BL01_16470 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) BL01_16480 ENOG4108RCM Nitroreductase BL01_16485 ENOG4108TZV Membrane BL01_16495 ENOG4105C2M dna polymerase I BL01_16500 ENOG4108VIA integral membrane protein BL01_16505 ENOG4105II7 pyrroline-5-carboxylate reductase BL01_16510 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BL01_16520 ENOG4105C9X ppx gppa phosphatase BL01_16530 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BL01_16545 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BL01_16570 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BL01_16585 ENOG4105W39 Membrane BL01_16590 ENOG4105CYM Glutathione S-transferase BL01_16605 ENOG4105CEY Amp-dependent synthetase and ligase BL01_16610 ENOG4105N42 UPF0307 protein BL01_16615 ENOG41080Z8 PHOSPHOCARRIER protein BL01_16635 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BL01_16640 ENOG4105DJ0 Poly(A) Polymerase BL01_16645 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BL01_16650 ENOG4105DXN mazG family BL01_16660 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BL01_16675 ENOG4105C6T cysteine synthase BL01_16680 ENOG4105BZU Histidine kinase BL01_16685 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase BL01_16690 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BL01_16695 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) BL01_16710 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BL01_16715 ENOG4105W8H transhydrogenase (subunit alpha BL01_16720 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BL01_16725 ENOG4106UX7 integral membrane protein BL01_16740 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BL01_16750 ENOG4107RSM transcriptional regulator BL01_16755 ENOG4105CUZ uba thif-type nad fad binding protein BL01_16765 ENOG4107QM5 aconitate hydratase BL01_16770 ENOG4105F8V Hydrolase, tatD family BL01_16785 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BL01_16805 ENOG4105BZU Histidine kinase BL01_16815 ENOG4108ZP8 Acetolactate synthase small subunit BL01_16820 ENOG4105C7K acetolactate synthase BL01_16845 ENOG4105DJY efflux transporter, rnd family, mfp subunit BL01_16850 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BL01_16855 ENOG4105ENJ RND efflux system, outer membrane lipoprotein BL01_16860 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BL01_16870 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BL01_16875 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BL01_16885 ENOG4105VW4 glutaredoxin 3 BL01_16905 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BL01_16910 ENOG4105C2D reductase BL01_16920 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BL01_16950 ENOG4105C84 Histidine ammonia-lyase BL01_16965 ENOG4105CEY Amp-dependent synthetase and ligase BL01_16980 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BL01_17000 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BL01_17020 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) BL01_17040 ENOG4105WVQ Fe-S assembly protein IscX BL01_17055 ENOG4105CN1 protease BL01_17070 ENOG4106HB6 Alpha beta hydrolase BL01_17080 ENOG4105C26 Dehydrogenase BL01_17085 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BL01_17090 ENOG4105C6Z Gluconate BL01_17095 ENOG4108UHU Aldolase BL01_17100 ENOG4105C01 Dihydroxy-acid dehydratase BL01_17115 ENOG4107BJW polysaccharide deacetylase BL01_17120 ENOG4105CND Glycosyl transferase, family 2 BL01_17125 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD BL01_17135 ENOG4105DEN Luciferase family BL01_17150 ENOG4105CC0 LysR family Transcriptional regulator BL01_17165 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BL01_17170 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BL01_17175 ENOG4105GVF (ABC) transporter BL01_17190 ENOG4105C1G acyl-Coa dehydrogenase BL01_17200 ENOG4108MEJ flavin reductase domain protein BL01_17205 ENOG4105D06 uba thif-type nad fad binding protein BL01_17225 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BL01_17230 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BL01_17240 ENOG4105C08 Histidine kinase BL01_17245 ENOG4105EEX Two component transcriptional regulator (Winged helix family BL01_17250 ENOG4105CFQ glutamine synthetase BL01_17265 ENOG4107S74 Lysophospholipid transporter LplT BL01_17270 ENOG4105CFU surface antigen BL01_17285 ENOG4107QIJ Aconitate hydratase 2 BL01_17295 ENOG4105EYW Ion transport protein BL01_17300 ENOG4105F27 Major Facilitator BL01_17315 ENOG4105DZ2 Transcriptional regulator BL01_17350 ENOG4105K8N protein family UPF0079, ATPase BL01_17355 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BL01_17375 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BL01_17430 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BL01_17435 ENOG4105D6S protein involved in catabolism of external DNA BL01_17465 ENOG4105E4C Lytic transglycosylase catalytic BL01_17475 ENOG4105C9A Phoh family BL01_17505 ENOG4105CS1 NAD(P)H quinone oxidoreductase BL01_17510 ENOG4107S2Z UPF0761 membrane protein BL01_17520 ENOG4108K2B transcriptional regulator BL01_17525 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BL01_17610 ENOG4108R0M Aminoglycoside BL01_17635 ENOG4105BZU Histidine kinase BL01_17645 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BL01_17685 ENOG4108K5H permease YjgP YjgQ family protein BL01_17690 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BL01_17695 ENOG4105CN1 protease BL01_17700 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BL01_17705 ENOG4107TUY Histidine kinase BL01_17715 ENOG41061WM D-Alanyl-D-Alanine BL01_17725 ENOG4105D6E homoserine dehydrogenase BL01_17730 ENOG4105T95 Thiol disulfide interChange protein BL01_17735 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BL01_17745 ENOG4105CE1 Ferrous iron transport protein b BL01_17760 ENOG4105CNI cell division protein FtsW BL01_17765 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) BL01_17770 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BL01_17775 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BL01_17800 ENOG4108RNG Permease of the drug metabolite transporter BL01_17805 ENOG4105DFG type I secretion outer membrane protein BL01_17810 ENOG4108UTW Plays a role in the regulation of phosphate uptake BL01_17825 ENOG4108HRK Histidine kinase BL01_17830 ENOG4108NEV two component transcriptional regulator, LytTR family BL01_17835 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BL01_17860 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS BL01_17875 ENOG4105GVR general secretion pathway protein D BL01_17880 ENOG4105TV9 FHA Domain-Containing protein BL01_17885 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BL01_17990 ENOG4107YAU phenylacetic acid degradation protein BL01_18000 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein BL01_18005 ENOG4105DZS Phenylacetate-CoA ligase BL01_18010 ENOG4105CHU acetyl-coa acetyltransferase BL01_18015 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BL01_18020 ENOG4108UKI Enoyl-CoA hydratase BL01_18025 ENOG4105E39 Enoyl-CoA hydratase BL01_18030 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BL01_18035 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit BL01_18040 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit BL01_18045 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit BL01_18050 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit BL01_18055 ENOG4105DXM phenylacetic acid degradation protein BL01_18060 ENOG4105EJQ L-serine dehydratase BL01_18065 ENOG4107QTZ amino acid BL01_18070 ENOG4105CZJ Aldehyde dehydrogenase BL01_18095 ENOG4105MWK D-amino acid dehydrogenase, small subunit BL01_18115 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BL01_18130 ENOG4108Z4X TRANSCRIPTIONal BL01_18145 ENOG4105CHH sulfate transporter BL01_18170 ENOG4105CY2 Citrate transporter BL01_18175 ENOG4105DTD Dehydrogenase BL01_18180 ENOG4105CK7 Sodium proline symporter BL01_18185 ENOG4105EW9 transcriptional regulator AsnC family BL01_18190 ENOG4105C26 Dehydrogenase BL01_18195 ENOG4105YGK Pfam:UPF0157 BL01_18210 ENOG4108T58 Mg2 transport protein CorA BL01_18220 ENOG4108YYC ycei family BL01_18230 ENOG4105CV1 Transketolase (EC 2.2.1.1) BL01_18255 ENOG4108HWY Beta-lactamase BL01_18275 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BL01_18280 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BL01_18290 ENOG4105DZG Dehydrogenase BL01_18385 ENOG4105DY2 Paraquat-inducible protein b BL01_18390 ENOG4105F1S paraquat-inducible protein a BL01_18405 ENOG4105CEB Aspartate aminotransferase BL01_18425 ENOG4105CSH Transporter BL01_18490 ENOG4105K56 Transcriptional regulator BL01_18495 ENOG4108ZHJ Organic hydroperoxide resistance protein BL01_18500 ENOG4107QHF type ii secretion system protein e BL01_18760 ENOG4108IQI permease BL01_18795 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BL01_18805 ENOG4108ZX5 transcriptional regulator BL01_18815 ENOG4105BZ1 (ABC) transporter BL01_18820 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme BL01_18825 ENOG4105XPP Protein of unknown function (DUF1275) BL01_18835 ENOG4105D5G Transposase BL01_18845 ENOG4108C33 Resolvase BL01_18850 ENOG4105D13 transposase BL01_18865 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BL01_18870 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BL01_18875 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BL01_18915 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BL01_18955 ENOG4105CK2 sodium dicarboxylate symporter BL01_19045 ENOG4105CW7 secretion protein, HlyD family BL01_19080 ENOG4105X0I Fimbrial BL01_19085 ENOG4105GQR Chaperone BL01_19165 ENOG4105X0I Fimbrial BL01_19235 ENOG4107T31 5'-nucleotidase BL01_19375 ENOG4105CK2 sodium dicarboxylate symporter BL01_19385 ENOG4105KVH Transcriptional regulator BL01_19390 ENOG4107RYR Transcriptional regulator, Crp Fnr family BL01_p0025 ENOG4105UGU tonB-dependent Receptor BL01_p0105 ENOG4105IYK transposase BL01_p0115 ENOG4105E5H Transposase BL01_p0125 ENOG4105CDW Resistance protein BL01_p0145 ENOG4105FA0 parb-like partition protein BL01_p0200 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS BL01_p0210 ENOG4105KK6 nuclease BL01_p0280 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BL01_p0360 ENOG4105T95 Thiol disulfide interChange protein BL01_p0395 ENOG4105K5T PilT protein BL01_p0465 ENOG4105F6A helicase BL01_p0470 ENOG4108HWY Beta-lactamase BL01_p0500 ENOG4105CUY Mechanosensitive ion channel BL01_p0510 ENOG4105R8C Transcriptional regulator BL01_p0520 ENOG4105EW9 transcriptional regulator AsnC family BL01_p0525 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity)