locus-tag	class	description
B856_00025	COG0733	neurotransmitter:sodium symporter activity
B856_00065	COG2233	PERMEase
B856_00080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B856_00115	COG2814	Major facilitator Superfamily
B856_00120	COG0656	L-ascorbic acid biosynthetic process
B856_00125	COG0583	DNA-binding transcription factor activity
B856_00135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B856_00140	COG1064	alcohol dehydrogenase
B856_00145	COG2818	Glycosylase
B856_00160	COG1194	a g-specific adenine glycosylase
B856_00180	COG2983	Belongs to the UPF0260 family
B856_00185	COG2133	pyrroloquinoline quinone binding
B856_00190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B856_00195	COG2116	formate transmembrane transporter activity
B856_00220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B856_00225	COG1335	isochorismatase
B856_00230	COG0385	Bile acid
B856_00235	COG0534	Mate efflux family protein
B856_00240	COG1683	Conserved Protein
B856_00260	COG0625	glutathione transferase activity
B856_00270	COG1113	amino acid transport
B856_00280	COG0523	cobalamin synthesis protein
B856_00290	COG2188	Transcriptional regulator
B856_00320	COG0010	Belongs to the arginase family
B856_00335	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B856_00340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B856_00350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B856_00355	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B856_00455	COG0534	Mate efflux family protein
B856_00460	COG0436	Aminotransferase
B856_00465	COG2733	membrane
B856_00480	COG2918	glutathione biosynthetic process
B856_00490	COG3501	Rhs element vgr protein
B856_00495	COG1388	LysM domain
B856_00495	COG0791	NLP P60 protein
B856_00510	COG3150	esterase
B856_00525	COG1028	Short-chain dehydrogenase reductase Sdr
B856_00530	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
B856_00540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B856_00550	COG2233	PERMEase
B856_00555	COG2351	hydroxyisourate hydrolase activity
B856_00590	COG3706	GGDEF domain
B856_00605	COG1393	Belongs to the ArsC family
B856_00610	COG0708	Exodeoxyribonuclease III
B856_00630	COG0189	ligase activity
B856_00650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B856_00660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B856_00675	COG4942	peptidase
B856_00685	COG0508	dehydrogenase complex catalyzes the overall conversion of
B856_00695	COG2119	membrane
B856_00700	COG4774	siderophore transport
B856_00705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B856_00705	COG0426	domain, Protein
B856_00730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B856_00750	COG1902	pentaerythritol trinitrate reductase activity
B856_00755	COG1519	Transferase
B856_00760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B856_00765	COG0668	transmembrane transport
B856_00775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B856_00780	COG1335	isochorismatase
B856_00785	COG1522	sequence-specific DNA binding
B856_00840	COG3111	PFAM Bacterial OB fold (BOF) protein
B856_00865	COG3243	poly(R)-hydroxyalkanoic acid synthase
B856_00870	COG0786	glutamate:sodium symporter activity
B856_00880	COG2186	Transcriptional regulator
B856_00930	COG0477	Major facilitator Superfamily
B856_00955	COG2985	domain, Protein
B856_00965	COG2995	paraquat-inducible protein a
B856_00970	COG3008	intermembrane lipid transfer
B856_00970	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B856_00990	COG0616	signal peptide processing
B856_00995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B856_01005	COG0573	inorganic phosphate transmembrane transporter activity
B856_01010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B856_01015	COG1113	amino acid transport
B856_01020	COG3961	Belongs to the TPP enzyme family
B856_01025	COG1522	sequence-specific DNA binding
B856_01035	COG0076	glutamate decarboxylase activity
B856_01040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B856_01050	COG1309	transcriptional regulator
B856_01065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B856_01100	COG0352	thiamine-phosphate diphosphorylase activity
B856_01125	COG0612	Peptidase, M16
B856_01140	COG0583	DNA-binding transcription factor activity
B856_01145	COG0477	Major facilitator Superfamily
B856_01165	COG1187	pseudouridine synthase activity
B856_01180	COG1686	Belongs to the peptidase S11 family
B856_01185	COG1252	NADH dehydrogenase
B856_01195	COG0415	Belongs to the DNA photolyase family
B856_01210	COG1215	transferase activity, transferring glycosyl groups
B856_01240	COG2070	2-Nitropropane dioxygenase
B856_01295	COG0556	nucleotide-excision repair
B856_01340	COG4221	oxidoreductase activity
B856_01350	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B856_01355	COG1381	Involved in DNA repair and RecF pathway recombination
B856_01365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B856_01380	COG0681	Belongs to the peptidase S26 family
B856_01395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B856_01415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B856_01420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B856_01425	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B856_01435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B856_01440	COG4208	sulfate ABC transporter
B856_01445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B856_01450	COG0583	DNA-binding transcription factor activity
B856_01455	COG4625	pathogenesis
B856_01470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B856_01485	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B856_01495	COG1051	belongs to the nudix hydrolase family
B856_01495	COG1056	cytidyltransferase-related domain
B856_01500	COG1024	Enoyl-CoA hydratase
B856_01505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B856_01515	COG2814	Major facilitator Superfamily
B856_01520	COG0047	phosphoribosylformylglycinamidine synthase activity
B856_01520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B856_01540	COG1473	amidohydrolase
B856_01545	COG0824	Thioesterase
B856_01565	COG0823	Involved in the tonB-independent uptake of proteins
B856_01585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B856_01620	COG0628	permease
B856_01630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B856_01635	COG0596	Alpha beta hydrolase
B856_01640	COG0616	signal peptide processing
B856_01640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B856_01650	COG0658	competence protein
B856_01650	COG2333	competence protein COMEC
B856_01655	COG1136	(ABC) transporter
B856_01660	COG4591	ABC-type transport system involved in lipoprotein release permease component
B856_01690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B856_01710	COG0463	Glycosyl transferase, family 2
B856_01740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B856_01745	COG1280	lysine exporter protein (LysE YggA)
B856_01755	COG0019	diaminopimelate decarboxylase activity
B856_01765	COG1113	amino acid transport
B856_01780	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
B856_01790	COG3339	Conserved Protein
B856_01795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B856_01800	COG0243	molybdopterin cofactor binding
B856_01805	COG1929	Belongs to the glycerate kinase type-1 family
B856_01820	COG0778	Nitroreductase
B856_01845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B856_01860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B856_01880	COG0741	lytic transglycosylase activity
B856_01900	COG0584	glycerophosphoryl diester phosphodiesterase
B856_01935	COG1376	ErfK ybiS ycfS ynhG family protein
B856_01940	COG2832	Protein of unknown function (DUF454)
B856_01950	COG5510	response to toxic substance
B856_01970	COG0840	transmembrane signaling receptor activity
B856_02010	COG3422	double-strand break repair
B856_02015	COG2824	Alkylphosphonate utilization operon protein PhnA
B856_02020	COG3189	MarR family transcriptional regulator
B856_02030	COG0354	folic acid binding
B856_02035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B856_02050	COG1902	pentaerythritol trinitrate reductase activity
B856_02055	COG4772	TonB-dependent receptor
B856_02060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B856_02065	COG0280	phosphate acetyltransferase
B856_02065	COG0857	belongs to the CobB CobQ family
B856_02070	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
B856_02070	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
B856_02090	COG0740	serine-type endopeptidase activity
B856_02100	COG4774	siderophore transport
B856_02110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B856_02120	COG2813	Specifically methylates the guanine in position
B856_02120	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B856_02220	COG0788	formyltetrahydrofolate deformylase activity
B856_02235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B856_02240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B856_02245	COG4651	solute:proton antiporter activity
B856_02245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B856_02265	COG0724	RNA recognition motif
B856_02270	COG0210	DNA helicase
B856_02295	COG1733	regulation of RNA biosynthetic process
B856_02315	COG1280	lysine exporter protein (LysE YggA)
B856_02320	COG1560	Kdo2-lipid A biosynthetic process
B856_02330	COG1301	dicarboxylic acid transport
B856_02385	COG0473	3-isopropylmalate dehydrogenase activity
B856_02450	COG0583	DNA-binding transcription factor activity
B856_02460	COG0625	glutathione transferase activity
B856_02465	COG2378	regulation of single-species biofilm formation
B856_02470	COG0546	phosphoglycolate phosphatase activity
B856_02480	COG1530	ribonuclease E activity
B856_02495	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B856_02510	COG2807	transmembrane transport
B856_02515	COG0590	tRNA wobble adenosine to inosine editing
B856_02525	COG0583	DNA-binding transcription factor activity
B856_02565	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B856_02565	COG2885	chlorophyll binding
B856_02630	COG1116	anion transmembrane transporter activity
B856_02635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B856_02645	COG0864	Transcriptional regulator
B856_02665	COG2249	NAD(P)H dehydrogenase (quinone) activity
B856_02670	COG0439	Biotin carboxylase
B856_02685	COG1063	alcohol dehydrogenase
B856_02695	COG1309	transcriptional regulator
B856_02720	COG0038	chloride channel
B856_02725	COG4770	biotin carboxylase activity
B856_02745	COG1914	H( )-stimulated, divalent metal cation uptake system
B856_02750	COG0583	DNA-binding transcription factor activity
B856_02765	COG3209	COG3209 Rhs family protein
B856_02770	COG3501	Rhs element vgr protein
B856_02795	COG1250	3-hydroxyacyl-CoA dehydrogenase
B856_02815	COG2814	Major facilitator Superfamily
B856_02830	COG1560	Kdo2-lipid A biosynthetic process
B856_02840	COG5006	permease, DMT superfamily
B856_02845	COG1522	sequence-specific DNA binding
B856_02865	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B856_02905	COG1538	Outer membrane efflux protein
B856_02910	COG1137	ATPase activity
B856_02915	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B856_02925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B856_02930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B856_02930	COG0517	IMP dehydrogenase activity
B856_02965	COG1733	regulation of RNA biosynthetic process
B856_02970	COG2814	Major facilitator Superfamily
B856_03005	COG1278	Cold shock
B856_03010	COG1280	lysine exporter protein (LysE YggA)
B856_03045	COG1570	exodeoxyribonuclease VII activity
B856_03095	COG0583	DNA-binding transcription factor activity
B856_03100	COG4638	Rieske (2fe-2S)
B856_03105	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
B856_03110	COG0543	2 iron, 2 sulfur cluster binding
B856_03110	COG0633	Ferredoxin
B856_03115	COG1028	Short-chain dehydrogenase reductase Sdr
B856_03120	COG3135	benzoate transporter
B856_03125	COG2814	Major facilitator Superfamily
B856_03140	COG1643	Atp-dependent helicase
B856_03145	COG0450	alkyl hydroperoxide reductase
B856_03155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B856_03175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B856_03205	COG2329	Antibiotic biosynthesis monooxygenase
B856_03220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B856_03285	COG2249	NAD(P)H dehydrogenase (quinone) activity
B856_03290	COG1733	regulation of RNA biosynthetic process
B856_03325	COG0667	Aldo Keto reductase
B856_03345	COG0583	DNA-binding transcription factor activity
B856_03350	COG2814	Major facilitator Superfamily
B856_03380	COG1335	isochorismatase
B856_03390	COG1012	belongs to the aldehyde dehydrogenase family
B856_03395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B856_03405	COG1113	amino acid transport
B856_03415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B856_03430	COG2814	Major facilitator Superfamily
B856_03440	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B856_03440	COG0352	thiamine-phosphate diphosphorylase activity
B856_03440	COG0351	phosphomethylpyrimidine kinase
B856_03460	COG1309	transcriptional regulator
B856_03465	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B856_03475	COG3706	GGDEF domain
B856_03485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B856_03495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B856_03500	COG3162	membrane
B856_03505	COG2205	protein histidine kinase activity
B856_03505	COG2198	Histidine kinase
B856_03505	COG0784	Response regulator, receiver
B856_03530	COG0640	Transcriptional regulator
B856_03540	COG2850	peptidyl-arginine hydroxylation
B856_03545	COG0424	maF-like protein
B856_03565	COG0191	fructose-bisphosphate aldolase activity
B856_03570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B856_03585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B856_03595	COG1192	Involved in chromosome partitioning
B856_03600	COG1475	DNA binding
B856_03605	COG0811	peptide transport
B856_03615	COG1132	(ABC) transporter
B856_03620	COG1663	tetraacyldisaccharide 4'-kinase activity
B856_03640	COG0084	hydrolase, TatD family'
B856_03655	COG2165	general secretion pathway protein
B856_03685	COG0590	tRNA wobble adenosine to inosine editing
B856_03705	COG0776	regulation of translation
B856_03735	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B856_03740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B856_03790	COG0339	signal peptide processing
B856_03800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B856_03835	COG0702	epimerase
B856_03840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B856_03860	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B856_03890	COG0316	Belongs to the HesB IscA family
B856_03895	COG0822	iron-sulfur transferase activity
B856_03920	COG0776	regulation of translation
B856_03925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B856_03930	COG2207	Transcriptional regulator
B856_03935	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B856_03940	COG1960	acyl-CoA dehydrogenase activity
B856_03945	COG1960	acyl-CoA dehydrogenase activity
B856_03960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B856_03980	COG4264	IucA IucC family
B856_03985	COG4264	IucA IucC family
B856_04045	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B856_04065	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B856_04070	COG0730	response to heat
B856_04090	COG4773	Receptor
B856_04095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B856_04110	COG1131	(ABC) transporter
B856_04115	COG0842	Transport permease protein
B856_04120	COG0842	Transport permease protein
B856_04175	COG2226	methyltransferase
B856_04200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B856_04235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B856_04245	COG0133	tryptophan synthase activity
B856_04260	COG3706	GGDEF domain
B856_04275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B856_04280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B856_04285	COG0022	dehydrogenase e1 component
B856_04290	COG0508	dehydrogenase complex catalyzes the overall conversion of
B856_04295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B856_04305	COG1063	alcohol dehydrogenase
B856_04310	COG3781	membrane
B856_04320	COG3453	Protein conserved in bacteria
B856_04320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B856_04330	COG0730	response to heat
B856_04345	COG3708	Transcriptional regulator
B856_04345	COG2207	Transcriptional regulator
B856_04350	COG1733	regulation of RNA biosynthetic process
B856_04355	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B856_04380	COG4521	taurine ABC transporter
B856_04385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B856_04405	COG0477	Major facilitator Superfamily
B856_04415	COG1027	Aspartate ammonia-lyase
B856_04430	COG0583	DNA-binding transcription factor activity
B856_04435	COG0583	DNA-binding transcription factor activity
B856_04440	COG0183	Belongs to the thiolase family
B856_04445	COG2031	fatty acid transporter
B856_04450	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B856_04460	COG0583	DNA-binding transcription factor activity
B856_04470	COG2610	gluconate transmembrane transporter activity
B856_04475	COG1028	Short-chain dehydrogenase reductase Sdr
B856_04480	COG1309	transcriptional regulator
B856_04515	COG0758	DNA mediated transformation
B856_04525	COG0697	spore germination
B856_04530	COG1309	transcriptional regulator
B856_04545	COG0386	Belongs to the glutathione peroxidase family
B856_04610	COG1121	(ABC) transporter
B856_04615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B856_04620	COG1280	lysine exporter protein (LysE YggA)
B856_04625	COG2837	iron assimilation
B856_04635	COG0281	malic enzyme
B856_04680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B856_04680	COG0519	Catalyzes the synthesis of GMP from XMP
B856_04685	COG4399	Belongs to the UPF0754 family
B856_04690	COG2259	Doxx family
B856_04695	COG0586	Pfam SNARE associated Golgi protein
B856_04710	COG1192	Involved in chromosome partitioning
B856_04720	COG0271	Belongs to the BolA IbaG family
B856_04740	COG2267	carboxylic ester hydrolase activity
B856_04755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B856_04765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B856_04765	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B856_04765	COG3321	synthase
B856_04765	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B856_04770	COG1960	acyl-CoA dehydrogenase activity
B856_04780	COG2197	response regulator
B856_04790	COG3916	Acyl-homoserine-lactone synthase
B856_04795	COG0477	Major facilitator Superfamily
B856_04800	COG1024	Enoyl-CoA hydratase
B856_04805	COG1024	Enoyl-CoA hydratase
B856_04810	COG1960	acyl-CoA dehydrogenase activity
B856_04815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B856_04835	COG1113	amino acid transport
B856_04840	COG1113	amino acid transport
B856_04845	COG0251	oxidation-reduction process
B856_04860	COG1522	sequence-specific DNA binding
B856_04885	COG0564	pseudouridine synthase activity
B856_04940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B856_04955	COG1802	Transcriptional regulator
B856_04960	COG1448	Aminotransferase
B856_04965	COG0277	FAD linked oxidase domain protein
B856_04975	COG2186	Transcriptional regulator
B856_04985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B856_04990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B856_05005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B856_05010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B856_05065	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B856_05095	COG0728	peptidoglycan biosynthetic process
B856_05100	COG3023	N-Acetylmuramoyl-L-alanine amidase
B856_05160	COG0546	phosphoglycolate phosphatase activity
B856_05165	COG1028	Short-chain dehydrogenase reductase Sdr
B856_05185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B856_05190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B856_05195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B856_05200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B856_05205	COG1116	anion transmembrane transporter activity
B856_05210	COG1309	transcriptional regulator
B856_05215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B856_05225	COG0196	riboflavin kinase activity
B856_05230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B856_05240	COG1047	Peptidyl-prolyl cis-trans
B856_05285	COG2050	protein possibly involved in aromatic compounds catabolism
B856_05295	COG3327	negative regulation of DNA-templated transcription, initiation
B856_05300	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B856_05305	COG0183	Belongs to the thiolase family
B856_05310	COG1250	3-hydroxyacyl-CoA dehydrogenase
B856_05315	COG1024	Enoyl-CoA hydratase
B856_05320	COG1024	Enoyl-CoA hydratase
B856_05325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B856_05330	COG2151	metal-sulfur cluster biosynthetic enzyme
B856_05335	COG3396	Phenylacetate-CoA oxygenase
B856_05340	COG3460	Phenylacetate-CoA oxygenase
B856_05345	COG3396	Phenylacetate-CoA oxygenase
B856_05350	COG2030	dehydratase
B856_05350	COG1012	belongs to the aldehyde dehydrogenase family
B856_05355	COG1760	l-serine dehydratase
B856_05360	COG0531	amino acid
B856_05365	COG1012	belongs to the aldehyde dehydrogenase family
B856_05380	COG0446	pyridine nucleotide-disulphide oxidoreductase
B856_05390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B856_05410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B856_05425	COG0789	Transcriptional regulator
B856_05450	COG2186	Transcriptional regulator
B856_05460	COG0583	DNA-binding transcription factor activity
B856_05465	COG4948	Mandelate Racemase Muconate Lactonizing
B856_05470	COG4829	muconolactone delta-isomerase
B856_05480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B856_05485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B856_05490	COG0183	Belongs to the thiolase family
B856_05495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B856_05505	COG1012	belongs to the aldehyde dehydrogenase family
B856_05515	COG3733	amine oxidase
B856_05525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B856_05535	COG1028	Short-chain dehydrogenase reductase Sdr
B856_05545	COG4638	Rieske (2fe-2S)
B856_05565	COG0154	amidase activity
B856_05580	COG2814	Major facilitator Superfamily
B856_05605	COG1960	acyl-CoA dehydrogenase activity
B856_05610	COG0583	DNA-binding transcription factor activity
B856_05615	COG1414	Transcriptional regulator
B856_05630	COG2391	methyltransferase activity
B856_05640	COG4993	Dehydrogenase
B856_05645	COG3659	wide pore channel activity
B856_05650	COG3420	alginic acid biosynthetic process
B856_05655	COG0710	3-dehydroquinate dehydratase activity
B856_05660	COG3485	protocatechuate 3,4-dioxygenase
B856_05665	COG3485	protocatechuate 3,4-dioxygenase
B856_05670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B856_05675	COG2271	Major facilitator Superfamily
B856_05680	COG0596	Alpha beta hydrolase
B856_05685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B856_05690	COG0183	Belongs to the thiolase family
B856_05695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B856_05700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B856_05710	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B856_05715	COG2323	membrane
B856_05760	COG0446	pyridine nucleotide-disulphide oxidoreductase
B856_05760	COG1902	pentaerythritol trinitrate reductase activity
B856_05775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B856_05785	COG0542	response to heat
B856_05790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B856_05820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B856_05825	COG0569	domain protein
B856_05830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B856_05845	COG4774	siderophore transport
B856_05850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B856_05860	COG1585	Membrane protein implicated in regulation of membrane protease activity
B856_05875	COG1294	oxidase, subunit
B856_05895	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
B856_05905	COG0552	protein localization to endoplasmic reticulum
B856_05935	COG0517	IMP dehydrogenase activity
B856_05935	COG0516	GMP reductase activity
B856_05940	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B856_05945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B856_05955	COG0583	DNA-binding transcription factor activity
B856_05960	COG0024	Methionine aminopeptidase
B856_05990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B856_05990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B856_05995	COG1105	Belongs to the carbohydrate kinase PfkB family
B856_06000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B856_06000	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B856_06000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B856_06025	COG3300	MHYT domain
B856_06025	COG5001	Diguanylate cyclase
B856_06040	COG2135	peptidase activity
B856_06045	COG0659	secondary active sulfate transmembrane transporter activity
B856_06060	COG1113	amino acid transport
B856_06070	COG1522	sequence-specific DNA binding
B856_06095	COG1011	Hydrolase
B856_06100	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B856_06110	COG2137	regulation of response to DNA damage stimulus
B856_06120	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B856_06155	COG0575	Belongs to the CDS family
B856_06160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B856_06180	COG3852	Histidine kinase
B856_06185	COG2204	response regulator
B856_06240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B856_06245	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
B856_06265	COG0697	spore germination
B856_06270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B856_06280	COG0303	'Molybdopterin
B856_06285	COG0315	cyclic pyranopterin monophosphate synthase activity
B856_06285	COG0521	Mo-molybdopterin cofactor biosynthetic process
B856_06300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B856_06305	COG0243	molybdopterin cofactor binding
B856_06315	COG0243	molybdopterin cofactor binding
B856_06320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B856_06325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B856_06325	COG2146	nitrite reductase [NAD(P)H] activity
B856_06335	COG0745	RESPONSE REGULATOR receiver
B856_06340	COG1116	anion transmembrane transporter activity
B856_06340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B856_06355	COG0511	ligase activity, forming carbon-carbon bonds
B856_06370	COG2814	Major facilitator Superfamily
B856_06440	COG0308	aminopeptidase N
B856_06445	COG0512	Glutamine amidotransferase of anthranilate synthase
B856_06455	COG3104	oligopeptide transport
B856_06470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B856_06505	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B856_06510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B856_06515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B856_06535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B856_06540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B856_06545	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B856_06560	COG1960	acyl-CoA dehydrogenase activity
B856_06565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B856_06570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B856_06585	COG2223	nitrite transmembrane transporter activity
B856_06595	COG0024	Methionine aminopeptidase
B856_06600	COG0052	Belongs to the universal ribosomal protein uS2 family
B856_06615	COG2207	Transcriptional regulator
B856_06640	COG2951	lytic endotransglycosylase activity
B856_06645	COG0772	Belongs to the SEDS family
B856_06660	COG0842	Transport permease protein
B856_06665	COG1131	(ABC) transporter
B856_06700	COG1538	Outer membrane efflux protein
B856_06710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B856_06725	COG4215	(ABC) transporter
B856_06730	COG4160	amino acid transport
B856_06735	COG4598	ABC transporter
B856_06745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B856_06755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B856_06770	COG1720	tRNA m6t6A37 methyltransferase activity
B856_06790	COG0745	RESPONSE REGULATOR receiver
B856_06795	COG0642	Histidine kinase
B856_06805	COG0494	nUDIX hydrolase
B856_06815	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B856_06820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B856_06825	COG3139	Protein of unknown function (DUF1315)
B856_06830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B856_06835	COG1301	dicarboxylic acid transport
B856_06840	COG1960	acyl-CoA dehydrogenase activity
B856_06845	COG2819	hydrolase of the alpha beta superfamily
B856_06855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B856_06865	COG2195	Cleaves the N-terminal amino acid of tripeptides
B856_06870	COG1234	tRNA 3'-trailer cleavage
B856_06900	COG2363	Small membrane protein
B856_06920	COG0513	Belongs to the DEAD box helicase family
B856_06930	COG0778	Nitroreductase
B856_06960	COG1286	toxin biosynthetic process
B856_06985	COG4783	chaperone-mediated protein folding
B856_06990	COG1610	YqeY-like protein
B856_06995	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B856_07050	COG4993	Dehydrogenase
B856_07120	COG2205	protein histidine kinase activity
B856_07130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B856_07150	COG0745	RESPONSE REGULATOR receiver
B856_07155	COG2205	protein histidine kinase activity
B856_07190	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B856_07220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B856_07225	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B856_07245	COG0583	DNA-binding transcription factor activity
B856_07265	COG0668	transmembrane transport
B856_07275	COG2081	HI0933 family
B856_07280	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B856_07310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B856_07310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B856_07320	COG0489	protein tyrosine kinase activity
B856_07370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B856_07380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B856_07395	COG0730	response to heat
B856_07405	COG1196	nuclear chromosome segregation
B856_07425	COG2223	nitrite transmembrane transporter activity
B856_07430	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
B856_07435	COG1877	trehalose-phosphatase activity
B856_07440	COG0596	Alpha beta hydrolase
B856_07440	COG2226	methyltransferase
B856_07440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B856_07455	COG4106	trans-aconitate 2-methyltransferase activity
B856_07470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B856_07475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B856_07480	COG0009	L-threonylcarbamoyladenylate synthase
B856_07485	COG3101	peptidyl-lysine hydroxylation
B856_07490	COG1399	metal-binding, possibly nucleic acid-binding protein
B856_07515	COG1652	LysM domain
B856_07520	COG0352	thiamine-phosphate diphosphorylase activity
B856_07520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B856_07520	COG0351	phosphomethylpyrimidine kinase
B856_07530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B856_07560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B856_07565	COG0129	dihydroxy-acid dehydratase activity
B856_07575	COG0583	DNA-binding transcription factor activity
B856_07580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B856_07590	COG2084	Dehydrogenase
B856_07595	COG2207	Transcriptional regulator
B856_07610	COG1064	alcohol dehydrogenase
B856_07625	COG1120	ATPase activity
B856_07645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B856_07765	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B856_07820	COG1028	Short-chain dehydrogenase reductase Sdr
B856_07835	COG2207	Transcriptional regulator
B856_07845	COG2205	protein histidine kinase activity
B856_07850	COG0745	RESPONSE REGULATOR receiver
B856_07855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B856_07860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B856_07865	COG1538	Outer membrane efflux protein
B856_07875	COG2072	flavoprotein involved in K transport
B856_07895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B856_07915	COG3539	Fimbrial protein
B856_07940	COG0753	catalase activity
B856_07945	COG3038	cytochrome b561
B856_07965	COG2267	carboxylic ester hydrolase activity
B856_07970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B856_07975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B856_07980	COG1012	belongs to the aldehyde dehydrogenase family
B856_07990	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B856_08000	COG1012	belongs to the aldehyde dehydrogenase family
B856_08005	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B856_08010	COG0583	DNA-binding transcription factor activity
B856_08020	COG1414	Transcriptional regulator
B856_08025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B856_08035	COG1840	ABC-type Fe3 transport system, periplasmic component
B856_08040	COG3842	ATPase activity
B856_08055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B856_08060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B856_08065	COG2814	Major facilitator Superfamily
B856_08070	COG1960	acyl-CoA dehydrogenase activity
B856_08090	COG1024	Enoyl-CoA hydratase
B856_08100	COG2814	Major facilitator Superfamily
B856_08110	COG0183	Belongs to the thiolase family
B856_08115	COG1250	3-hydroxyacyl-CoA dehydrogenase
B856_08120	COG1028	Short-chain dehydrogenase reductase Sdr
B856_08125	COG1024	Enoyl-CoA hydratase
B856_08130	COG1960	acyl-CoA dehydrogenase activity
B856_08135	COG2814	Major facilitator Superfamily
B856_08140	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B856_08145	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B856_08155	COG2814	Major facilitator Superfamily
B856_08165	COG1960	acyl-CoA dehydrogenase activity
B856_08180	COG0583	DNA-binding transcription factor activity
B856_08195	COG1024	Enoyl-CoA hydratase
B856_08200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B856_08205	COG1960	acyl-CoA dehydrogenase activity
B856_08210	COG1309	transcriptional regulator
B856_08215	COG0318	PFAM AMP-dependent synthetase and ligase
B856_08235	COG0583	DNA-binding transcription factor activity
B856_08285	COG1028	Short-chain dehydrogenase reductase Sdr
B856_08300	COG0583	DNA-binding transcription factor activity
B856_08305	COG4221	oxidoreductase activity
B856_08310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B856_08320	COG0534	Mate efflux family protein
B856_08335	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B856_08370	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B856_08375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B856_08390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B856_08400	COG0644	oxidoreductase
B856_08400	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B856_08405	COG0425	Belongs to the sulfur carrier protein TusA family
B856_08410	COG4535	Mg2 and Co2 transporter CorC
B856_08420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B856_08440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B856_08445	COG0475	glutathione-regulated potassium exporter activity
B856_08445	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B856_08450	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B856_08460	COG0484	heat shock protein binding
B856_08465	COG0789	Transcriptional regulator
B856_08470	COG0598	Magnesium transport protein CorA
B856_08490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B856_08495	COG1074	ATP-dependent DNA helicase activity
B856_08500	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B856_08520	COG2226	methyltransferase
B856_08535	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B856_08540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B856_08555	COG2111	Na H antiporter
B856_08555	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B856_08560	COG1006	Multisubunit Na H antiporter MnhC subunit
B856_08565	COG0651	ATP synthesis coupled electron transport
B856_08575	COG2212	antiporter activity
B856_08595	COG0195	Participates in both transcription termination and antitermination
B856_08645	COG0237	dephospho-CoA kinase activity
B856_08655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B856_08670	COG0497	DNA recombination
B856_08680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B856_08710	COG2169	Transcriptional regulator
B856_08710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B856_08715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B856_08785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B856_08800	COG0326	Molecular chaperone. Has ATPase activity
B856_08815	COG2056	Na+-H+ antiporter family
B856_08820	COG0596	Alpha beta hydrolase
B856_08960	COG0488	(ABC) transporter
B856_08970	COG4221	oxidoreductase activity
B856_08975	COG0659	secondary active sulfate transmembrane transporter activity
B856_08985	COG0745	RESPONSE REGULATOR receiver
B856_08995	COG0427	acetyl-CoA hydrolase
B856_09005	COG0513	Belongs to the DEAD box helicase family
B856_09025	COG0408	coproporphyrinogen oxidase activity
B856_09040	COG1960	acyl-CoA dehydrogenase activity
B856_09050	COG1983	PspC domain protein
B856_09055	COG0517	IMP dehydrogenase activity
B856_09100	COG0583	DNA-binding transcription factor activity
B856_09140	COG1012	belongs to the aldehyde dehydrogenase family
B856_09150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B856_09155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B856_09165	COG0833	amino acid
B856_09195	COG1192	Involved in chromosome partitioning
B856_09200	COG0628	permease
B856_09210	COG1289	transmembrane transporter activity
B856_09225	COG2249	NAD(P)H dehydrogenase (quinone) activity
B856_09230	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B856_09240	COG0277	FAD linked oxidase domain protein
B856_09245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B856_09270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B856_09275	COG5380	lipid catabolic process
B856_09295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B856_09345	COG0194	GDP metabolic process
B856_09355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B856_09375	COG3307	-O-antigen
B856_09395	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B856_09400	COG1704	LemA family
B856_09410	COG0493	'glutamate synthase
B856_09415	COG0070	glutamate synthase
B856_09415	COG0069	glutamate synthase activity
B856_09415	COG0067	glutamate synthase
B856_09465	COG2226	methyltransferase
B856_09480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B856_09485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B856_09535	COG0833	amino acid
B856_09545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B856_09570	COG0583	DNA-binding transcription factor activity
B856_09605	COG2951	lytic endotransglycosylase activity
B856_09610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B856_09630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B856_09640	COG0671	phosphoesterase, PA-phosphatase related
B856_09645	COG0861	Integral membrane protein TerC family
B856_09655	COG0754	glutathionylspermidine amidase activity
B856_09665	COG0402	S-adenosylhomocysteine deaminase activity
B856_09685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B856_09690	COG1230	cation diffusion facilitator family transporter
B856_09705	COG0706	membrane insertase activity
B856_09720	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B856_09730	COG0592	DNA-directed DNA polymerase activity
B856_09740	COG0187	DNA topoisomerase II activity
B856_09750	COG0586	Pfam SNARE associated Golgi protein
B856_09755	COG0488	(ABC) transporter
B856_09780	COG0596	Alpha beta hydrolase
B856_09785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B856_09790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B856_09805	COG0800	Aldolase
B856_09815	COG3265	gluconokinase activity
B856_09820	COG1012	belongs to the aldehyde dehydrogenase family
B856_09830	COG2267	carboxylic ester hydrolase activity
B856_09845	COG0793	Belongs to the peptidase S41A family
B856_09880	COG1426	Protein conserved in bacteria
B856_09920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B856_09925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B856_09935	COG0318	PFAM AMP-dependent synthetase and ligase
B856_09950	COG2986	histidine ammonia-lyase
B856_09990	COG1028	Short-chain dehydrogenase reductase Sdr
B856_09995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B856_10015	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B856_10025	COG1162	GTPase activity
B856_10030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B856_10045	COG1538	Outer membrane efflux protein
B856_10050	COG0577	efflux transmembrane transporter activity
B856_10050	COG1136	(ABC) transporter
B856_10055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B856_10080	COG0028	Belongs to the TPP enzyme family
B856_10085	COG0440	acetolactate synthase activity
B856_10115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B856_10130	COG0084	hydrolase, TatD family'
B856_10145	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B856_10150	COG0583	DNA-binding transcription factor activity
B856_10160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B856_10165	COG2814	Major facilitator Superfamily
B856_10175	COG0697	spore germination
B856_10180	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B856_10185	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
B856_10190	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B856_10205	COG3622	Belongs to the hyi family
B856_10210	COG2084	Dehydrogenase
B856_10215	COG1024	Enoyl-CoA hydratase
B856_10220	COG0784	Response regulator, receiver
B856_10220	COG5002	protein histidine kinase activity
B856_10220	COG2205	protein histidine kinase activity
B856_10240	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B856_10250	COG3956	TIGRFAM MazG family protein
B856_10255	COG1555	photosystem II stabilization
B856_10260	COG0617	tRNA 3'-terminal CCA addition
B856_10265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B856_10285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B856_10290	COG3028	Belongs to the UPF0307 family
B856_10295	COG0318	PFAM AMP-dependent synthetase and ligase
B856_10310	COG0625	glutathione transferase activity
B856_10315	COG1238	metal cluster binding
B856_10330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B856_10355	COG0072	phenylalanine-tRNA ligase activity
B856_10380	COG0248	Ppx GppA phosphatase
B856_10390	COG0037	tRNA processing
B856_10435	COG0557	exoribonuclease II activity
B856_10440	COG0339	signal peptide processing
B856_10445	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B856_10485	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B856_10490	COG1960	acyl-CoA dehydrogenase activity
B856_10515	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B856_10525	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B856_10645	COG0626	cystathionine gamma-synthase activity
B856_10650	COG0433	COG0433 Predicted ATPase
B856_10655	COG1017	nitric oxide dioxygenase activity
B856_10655	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B856_10660	COG1959	2 iron, 2 sulfur cluster binding
B856_10675	COG1301	dicarboxylic acid transport
B856_10680	COG1946	Acyl-CoA thioesterase
B856_10700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B856_10705	COG1040	competence protein
B856_10710	COG0494	nUDIX hydrolase
B856_10720	COG0598	Magnesium transport protein CorA
B856_10730	COG2854	intermembrane phospholipid transfer
B856_10740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B856_10745	COG1127	ABC transporter
B856_10770	COG3453	Protein conserved in bacteria
B856_10770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B856_10785	COG1607	acyl-coa hydrolase
B856_10815	COG2350	Protein conserved in bacteria
B856_10825	COG0613	PHP domain protein
B856_10830	COG3781	membrane
B856_10840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B856_10845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B856_10855	COG1862	Preprotein translocase
B856_10885	COG2205	protein histidine kinase activity
B856_10890	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B856_10910	COG0726	polysaccharide deacetylase
B856_10915	COG0463	Glycosyl transferase, family 2
B856_10920	COG0438	transferase activity, transferring glycosyl groups
B856_10985	COG0625	glutathione transferase activity
B856_10990	COG0583	DNA-binding transcription factor activity
B856_10995	COG1960	acyl-CoA dehydrogenase activity
B856_11000	COG1960	acyl-CoA dehydrogenase activity
B856_11010	COG2205	protein histidine kinase activity
B856_11015	COG0745	RESPONSE REGULATOR receiver
B856_11020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B856_11040	COG2096	Adenosyltransferase
B856_11055	COG0133	tryptophan synthase activity
B856_11090	COG0285	dihydrofolate synthase activity
B856_11110	COG0450	alkyl hydroperoxide reductase
B856_11125	COG0477	Major facilitator Superfamily
B856_11130	COG1272	protein, Hemolysin III
B856_11160	COG0183	Belongs to the thiolase family
B856_11165	COG2207	Transcriptional regulator
B856_11185	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B856_11205	COG0183	Belongs to the thiolase family
B856_11215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B856_11215	COG2885	chlorophyll binding
B856_11225	COG1690	Belongs to the RtcB family
B856_11230	COG0833	amino acid
B856_11240	COG2233	PERMEase
B856_11270	COG2094	Belongs to the DNA glycosylase MPG family
B856_11275	COG4772	TonB-dependent receptor
B856_11300	COG1773	rubredoxin
B856_11305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B856_11315	COG0583	DNA-binding transcription factor activity
B856_11340	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B856_11345	COG4181	ATPase activity
B856_11390	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B856_11410	COG0306	phosphate transporter
B856_11420	COG3958	Transketolase
B856_11425	COG3959	Transketolase, thiamine diphosphate binding domain
B856_11430	COG2271	Major facilitator Superfamily
B856_11435	COG1028	Short-chain dehydrogenase reductase Sdr
B856_11440	COG0583	DNA-binding transcription factor activity
B856_11455	COG2223	nitrite transmembrane transporter activity
B856_11460	COG2207	Transcriptional regulator
B856_11465	COG2066	Belongs to the glutaminase family
B856_11470	COG0242	peptide deformylase activity
B856_11480	COG0477	Major facilitator Superfamily
B856_11490	COG0028	Belongs to the TPP enzyme family
B856_11505	COG1028	Short-chain dehydrogenase reductase Sdr
B856_11510	COG2267	carboxylic ester hydrolase activity
B856_11520	COG2271	Major facilitator Superfamily
B856_11525	COG0446	pyridine nucleotide-disulphide oxidoreductase
B856_11535	COG1028	Short-chain dehydrogenase reductase Sdr
B856_11555	COG1414	Transcriptional regulator
B856_11570	COG1024	Enoyl-CoA hydratase
B856_11580	COG1215	transferase activity, transferring glycosyl groups
B856_11585	COG0726	polysaccharide deacetylase
B856_11585	COG1649	PFAM Uncharacterised BCR, COG1649
B856_11595	COG4681	YaeQ
B856_11605	COG0523	cobalamin synthesis protein
B856_11615	COG1607	acyl-coa hydrolase
B856_11625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B856_11630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B856_11635	COG1309	transcriptional regulator
B856_11665	COG2040	homocysteine
B856_11670	COG0531	amino acid
B856_11725	COG1595	DNA-templated transcription, initiation
B856_11735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B856_11740	COG0477	Major facilitator Superfamily
B856_11760	COG0084	hydrolase, TatD family'
B856_11850	COG0582	viral genome integration into host DNA
B856_11945	COG0592	DNA-directed DNA polymerase activity
B856_11985	COG2026	Addiction module toxin, RelE StbE family
B856_12190	COG1484	DNA-dependent DNA replication
B856_12285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B856_12355	COG0405	Gamma-glutamyltransferase
B856_12360	COG2814	Major facilitator Superfamily
B856_12370	COG2050	protein possibly involved in aromatic compounds catabolism
B856_12385	COG1090	epimerase
B856_12405	COG0420	3'-5' exonuclease activity
B856_12435	COG0735	belongs to the Fur family
B856_12440	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B856_12460	COG0121	glutamine amidotransferase
B856_12475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B856_12485	COG0210	DNA helicase
B856_12490	COG2885	chlorophyll binding
B856_12495	COG0204	Acyl-transferase
B856_12510	COG2894	cell division
B856_12525	COG1012	belongs to the aldehyde dehydrogenase family
B856_12545	COG1960	acyl-CoA dehydrogenase activity
B856_12550	COG1028	Short-chain dehydrogenase reductase Sdr
B856_12555	COG3829	transcription factor binding
B856_12565	COG3162	membrane
B856_12580	COG1012	belongs to the aldehyde dehydrogenase family
B856_12595	COG0753	catalase activity
B856_12620	COG1846	Transcriptional regulator
B856_12625	COG1902	pentaerythritol trinitrate reductase activity
B856_12625	COG0446	pyridine nucleotide-disulphide oxidoreductase
B856_12635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B856_12665	COG1309	transcriptional regulator
B856_12675	COG1335	isochorismatase
B856_12680	COG0583	DNA-binding transcription factor activity
B856_12690	COG0475	glutathione-regulated potassium exporter activity
B856_12690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B856_12700	COG1473	amidohydrolase
B856_12710	COG2831	hemolysin activation secretion protein
B856_12715	COG3210	domain, Protein
B856_12765	COG0583	DNA-binding transcription factor activity
B856_12790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B856_12795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B856_12815	COG1566	PFAM secretion protein HlyD family protein
B856_12830	COG1012	belongs to the aldehyde dehydrogenase family
B856_12845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B856_12860	COG0358	DNA primase activity
B856_12870	COG0564	pseudouridine synthase activity
B856_12895	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B856_12910	COG0583	DNA-binding transcription factor activity
B856_12915	COG0473	3-isopropylmalate dehydrogenase activity
B856_12935	COG1012	belongs to the aldehyde dehydrogenase family
B856_12955	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B856_12955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B856_13055	COG0069	glutamate synthase activity
B856_13075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B856_13085	COG1454	alcohol dehydrogenase
B856_13090	COG0824	Thioesterase
B856_13105	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B856_13135	COG0183	Belongs to the thiolase family
B856_13145	COG0583	DNA-binding transcription factor activity
B856_13160	COG1522	sequence-specific DNA binding
B856_13165	COG3135	benzoate transporter
B856_13175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B856_13195	COG0589	response to stress
B856_13200	COG0488	(ABC) transporter
B856_13220	COG4773	Receptor
B856_13525	COG5410	chromosome segregation
B856_13550	COG2321	neutral zinc metallopeptidase
B856_13555	COG2354	Protein conserved in bacteria
B856_13575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B856_13590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B856_13595	COG1053	succinate dehydrogenase
B856_13600	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B856_13605	COG2009	succinate dehydrogenase
B856_13645	COG2921	Belongs to the UPF0250 family
B856_13650	COG0321	lipoyl(octanoyl) transferase activity
B856_13665	COG0531	amino acid
B856_13675	COG1733	regulation of RNA biosynthetic process
B856_13680	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B856_13685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B856_13685	COG1648	precorrin-2 dehydrogenase activity
B856_13700	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B856_13730	COG0671	phosphoesterase, PA-phosphatase related
B856_13735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B856_13745	COG1538	Outer membrane efflux protein
B856_13750	COG0393	Putative heavy-metal-binding
B856_13755	COG0393	Putative heavy-metal-binding
B856_13765	COG1028	Short-chain dehydrogenase reductase Sdr
B856_13775	COG0525	valine-tRNA ligase activity
B856_13795	COG0583	DNA-binding transcription factor activity
B856_13800	COG0004	ammonium transporteR
B856_13810	COG0642	Histidine kinase
B856_13815	COG0745	RESPONSE REGULATOR receiver
B856_13820	COG1301	dicarboxylic acid transport
B856_13830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B856_13835	COG2011	ABC-type metal ion transport system permease component
B856_13840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B856_13845	COG1464	Belongs to the NlpA lipoprotein family
B856_13850	COG0151	Belongs to the GarS family
B856_13855	COG0138	bifunctional purine biosynthesis protein purh
B856_13860	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
B856_13895	COG2308	Evidence 4 Homologs of previously reported genes of
B856_13905	COG1305	Transglutaminase-like
B856_13915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B856_13920	COG0305	Participates in initiation and elongation during chromosome replication
B856_13945	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B856_13955	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B856_13960	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B856_13985	COG0726	polysaccharide deacetylase
B856_13985	COG1649	PFAM Uncharacterised BCR, COG1649
B856_13990	COG1215	transferase activity, transferring glycosyl groups
B856_13995	COG3658	cytochrome
B856_14005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B856_14020	COG0583	DNA-binding transcription factor activity
B856_14040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B856_14045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B856_14060	COG1960	acyl-CoA dehydrogenase activity
B856_14065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B856_14070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B856_14095	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B856_14100	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B856_14110	COG2205	protein histidine kinase activity
B856_14115	COG0745	RESPONSE REGULATOR receiver
B856_14120	COG0174	glutamine synthetase
B856_14140	COG0729	surface antigen
B856_14165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B856_14170	COG2814	Major facilitator Superfamily
B856_14185	COG0583	DNA-binding transcription factor activity
B856_14200	COG1187	pseudouridine synthase activity
B856_14220	COG0802	atpase or kinase
B856_14225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B856_14235	COG1923	regulation of RNA biosynthetic process
B856_14240	COG0697	spore germination
B856_14255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B856_14270	COG0519	Catalyzes the synthesis of GMP from XMP
B856_14270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B856_14275	COG4302	ethanolamine ammonia-lyase activity
B856_14280	COG4303	Ethanolamine ammonia lyase large subunit
B856_14285	COG0531	amino acid
B856_14305	COG1454	alcohol dehydrogenase
B856_14310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B856_14320	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B856_14340	COG0308	aminopeptidase N
B856_14350	COG4221	oxidoreductase activity
B856_14365	COG0446	pyridine nucleotide-disulphide oxidoreductase
B856_14365	COG1902	pentaerythritol trinitrate reductase activity
B856_14375	COG5001	Diguanylate cyclase
B856_14375	COG4251	negative regulation of phosphorylation
B856_14375	COG3706	GGDEF domain
B856_14375	COG2203	Gaf domain
B856_14385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B856_14405	COG4172	Belongs to the ABC transporter superfamily
B856_14410	COG4239	(ABC) transporter, permease
B856_14415	COG4174	ABC transporter (Permease)
B856_14425	COG1388	LysM domain
B856_14425	COG0741	lytic transglycosylase activity
B856_14425	COG1388	LysM domain
B856_14425	COG0741	lytic transglycosylase activity
B856_14430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B856_14470	COG0583	DNA-binding transcription factor activity
B856_14475	COG1279	arginine transmembrane transporter activity
B856_14495	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B856_14500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B856_14505	COG0006	proline dipeptidase activity
B856_14555	COG3739	integral membrane protein
B856_14570	COG1169	isochorismate synthase
B856_14580	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B856_14590	COG1132	(ABC) transporter
B856_14605	COG1535	isochorismatase
B856_14605	COG3433	isochorismatase activity
B856_14610	COG1021	2,3-dihydroxybenzoate-AMP ligase
B856_14615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B856_14625	COG4774	siderophore transport
B856_14630	COG4607	ABC-type enterochelin transport system periplasmic component
B856_14635	COG4604	ABC transporter, ATP-binding protein
B856_14640	COG4605	iron ion homeostasis
B856_14645	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B856_14650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B856_14665	COG2964	Protein conserved in bacteria
B856_14675	COG1741	Belongs to the pirin family
B856_14700	COG1309	transcriptional regulator
B856_14710	COG4948	Mandelate Racemase Muconate Lactonizing
B856_14715	COG2814	Major facilitator Superfamily
B856_14750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B856_14750	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B856_14755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B856_14770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B856_14775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B856_14780	COG0583	DNA-binding transcription factor activity
B856_14785	COG1113	amino acid transport
B856_14805	COG2508	Transcriptional regulator
B856_14805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B856_14840	COG2879	small protein
B856_14845	COG1966	Carbon starvation protein
B856_14890	COG1067	ATP-dependent peptidase activity
B856_14895	COG0583	DNA-binding transcription factor activity
B856_14920	COG1686	Belongs to the peptidase S11 family
B856_14925	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B856_15000	COG0606	chelatase, subunit chli
B856_15010	COG0347	Belongs to the P(II) protein family
B856_15015	COG0004	ammonium transporteR
B856_15025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B856_15025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B856_15065	COG0795	lipopolysaccharide-transporting ATPase activity
B856_15070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B856_15075	COG0793	Belongs to the peptidase S41A family
B856_15090	COG2197	response regulator
B856_15100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B856_15110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B856_15115	COG4974	Belongs to the 'phage' integrase family
B856_15140	COG0772	Belongs to the SEDS family
B856_15145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B856_15150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B856_15155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B856_15180	COG0697	spore germination
B856_15185	COG1538	Outer membrane efflux protein
B856_15205	COG3275	phosphorelay sensor kinase activity
B856_15215	COG0181	hydroxymethylbilane synthase activity
B856_15260	COG1716	ATPase activity
B856_15265	COG0546	phosphoglycolate phosphatase activity
B856_15300	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B856_15310	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B856_15310	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B856_15310	COG0506	proline dehydrogenase activity
B856_15315	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B856_15330	COG3698	Phosphodiester glycosidase
B856_15340	COG2353	YceI-like domain
B856_15350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B856_15395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B856_15395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B856_15420	COG3539	Fimbrial protein
B856_15425	COG3121	Chaperone
B856_15450	COG0697	spore germination
B856_15460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B856_15470	COG0583	DNA-binding transcription factor activity
B856_15495	COG1309	transcriptional regulator
B856_15510	COG1522	sequence-specific DNA binding
B856_15520	COG1126	abc transporter atp-binding protein
B856_15525	COG0765	amino acid transport
B856_15530	COG0765	amino acid transport
B856_15560	COG1464	Belongs to the NlpA lipoprotein family
B856_15570	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B856_15575	COG2011	ABC-type metal ion transport system permease component
B856_15580	COG0012	GTP binding
B856_15605	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B856_15645	COG0386	Belongs to the glutathione peroxidase family
B856_15655	COG0436	Aminotransferase
B856_15695	COG3634	alkyl hydroperoxide reductase activity
B856_15705	COG1183	phosphatidylcholine synthase activity
B856_15710	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B856_15740	COG0739	heme binding
B856_15740	COG1196	nuclear chromosome segregation
B856_15740	COG0741	lytic transglycosylase activity
B856_15750	COG1702	phosphate starvation-inducible protein PhoH
B856_15785	COG1295	ribonuclease BN
B856_15790	COG0697	spore germination
B856_15795	COG2169	Transcriptional regulator
B856_15800	COG0179	Fumarylacetoacetate (FAA) hydrolase
B856_15875	COG1752	Esterase of the alpha-beta hydrolase superfamily
B856_15890	COG2315	Protein conserved in bacteria
B856_15895	COG0142	geranyltranstransferase activity
B856_15900	COG2828	Protein conserved in bacteria
B856_15905	COG1113	amino acid transport
B856_15925	COG2207	Transcriptional regulator
B856_15955	COG2249	NAD(P)H dehydrogenase (quinone) activity
B856_15975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B856_15985	COG1530	ribonuclease E activity
B856_15990	COG0424	maF-like protein
B856_15995	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B856_16000	COG1792	Involved in formation and maintenance of cell shape
B856_16005	COG1077	Cell shape determining protein MreB Mrl
B856_16010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B856_16020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B856_16055	COG0583	DNA-binding transcription factor activity
B856_16060	COG0798	PFAM Bile acid sodium symporter
B856_16065	COG0640	Transcriptional regulator
B856_16080	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B856_16090	COG0583	DNA-binding transcription factor activity
B856_16100	COG1953	Uracil, thiamine, allantoin
B856_16110	COG2175	clavaminate synthase activity
B856_16115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B856_16120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B856_16125	COG4521	taurine ABC transporter
B856_16135	COG0477	Major facilitator Superfamily
B856_16155	COG1271	oxidase subunit
B856_16160	COG1294	oxidase, subunit
B856_16170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B856_16190	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B856_16210	COG3052	prosthetic group binding
B856_16215	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
B856_16230	COG2814	Major facilitator Superfamily
B856_16250	COG1346	cytolysis
B856_16260	COG0583	DNA-binding transcription factor activity
B856_16265	COG0625	glutathione transferase activity
B856_16270	COG0625	glutathione transferase activity
B856_16275	COG0583	DNA-binding transcription factor activity
B856_16295	COG1045	serine acetyltransferase
B856_16300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B856_16305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B856_16310	COG1280	lysine exporter protein (LysE YggA)
B856_16320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B856_16325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B856_16330	COG1126	abc transporter atp-binding protein
B856_16335	COG0765	amino acid transport
B856_16340	COG0765	amino acid transport
B856_16355	COG0784	Response regulator, receiver
B856_16355	COG2205	protein histidine kinase activity
B856_16375	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B856_16405	COG1289	transmembrane transporter activity
B856_16410	COG2814	Major facilitator Superfamily
B856_16430	COG1115	amino acid carrier protein
B856_16435	COG1752	Esterase of the alpha-beta hydrolase superfamily
B856_16440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B856_16445	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
B856_16480	COG2199	diguanylate cyclase activity
B856_16490	COG1408	metallophosphoesterase
B856_16495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B856_16505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B856_16525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B856_16530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B856_16545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B856_16555	COG2969	positive regulation of protein catabolic process
B856_16575	COG1960	acyl-CoA dehydrogenase activity
B856_16580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B856_16595	COG1309	transcriptional regulator
B856_16600	COG1960	acyl-CoA dehydrogenase activity
B856_16620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B856_16630	COG0655	NAD(P)H dehydrogenase (quinone) activity
B856_16665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B856_16685	COG1253	flavin adenine dinucleotide binding
B856_16695	COG2860	membrane
B856_16700	COG0477	Major facilitator Superfamily
B856_16710	COG0318	PFAM AMP-dependent synthetase and ligase
B856_16725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B856_16745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B856_16790	COG1214	PFAM Peptidase M22, glycoprotease
B856_16815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B856_16820	COG0561	phosphatase activity
B856_16830	COG2132	Multicopper oxidase
B856_16835	COG3667	copper resistance
B856_16850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B856_16855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B856_16860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B856_16935	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B856_16945	COG0753	catalase activity
B856_16965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B856_17025	COG3433	isochorismatase activity
B856_17025	COG1535	isochorismatase
B856_17030	COG1028	Short-chain dehydrogenase reductase Sdr
B856_17035	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B856_17040	COG4149	molybdate abc transporter
B856_17045	COG0725	ABC transporter, periplasmic molybdate-binding protein
B856_17055	COG4638	Rieske (2fe-2S)
B856_17060	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
B856_17065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B856_17065	COG0543	2 iron, 2 sulfur cluster binding
B856_17080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B856_17090	COG1028	Short-chain dehydrogenase reductase Sdr
B856_17095	COG0412	Dienelactone hydrolase
B856_17105	COG2207	Transcriptional regulator
B856_17115	COG1765	OsmC-like protein
B856_17165	COG2885	chlorophyll binding
B856_17175	COG0625	glutathione transferase activity
B856_17180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B856_17200	COG3634	alkyl hydroperoxide reductase activity
B856_17210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B856_17230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B856_17235	COG0477	Major facilitator Superfamily
B856_17285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B856_17290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B856_17315	COG0505	Belongs to the CarA family
B856_17335	COG0589	response to stress
B856_17350	COG2843	Capsule synthesis protein
B856_17450	COG1063	alcohol dehydrogenase
B856_17455	COG0583	DNA-binding transcription factor activity
B856_17460	COG1960	acyl-CoA dehydrogenase activity
B856_17465	COG2814	Major facilitator Superfamily
B856_17470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B856_17480	COG1053	succinate dehydrogenase
B856_17485	COG0583	DNA-binding transcription factor activity
B856_17500	COG0583	DNA-binding transcription factor activity
B856_17510	COG1473	amidohydrolase
B856_17530	COG0583	DNA-binding transcription factor activity
B856_17540	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B856_17545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B856_17575	COG0384	phenazine biosynthesis protein PhzF
B856_17630	COG2851	Citrate transporter
B856_17640	COG1253	flavin adenine dinucleotide binding
B856_17685	COG0804	urea catabolic process
B856_17695	COG0830	nickel cation binding
B856_17710	COG0742	ribosomal rna small subunit methyltransferase
B856_17715	COG0768	penicillin binding
B856_17740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B856_17745	COG2878	Part of a membrane complex involved in electron transport
B856_17750	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B856_17760	COG3384	dioxygenase
B856_17795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B856_17805	COG1846	Transcriptional regulator
B856_17810	COG1764	response to oxidative stress
B856_17915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B856_17930	COG1309	transcriptional regulator
B856_17935	COG1741	Belongs to the pirin family
B856_17950	COG2072	flavoprotein involved in K transport
B856_17960	COG2252	PERMEase
B856_17965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B856_17970	COG3038	cytochrome b561
B856_17980	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B856_18000	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B856_18010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B856_18025	COG0667	Aldo Keto reductase
B856_18050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B856_18055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B856_18060	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B856_18070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B856_18090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B856_18105	COG0456	acetyltransferase
B856_18115	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B856_18120	COG0492	ferredoxin-NADP+ reductase activity
B856_18125	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B856_18125	COG1674	ftsk spoiiie
B856_18130	COG1280	lysine exporter protein (LysE YggA)
B856_18165	COG0589	response to stress
B856_18170	COG0659	secondary active sulfate transmembrane transporter activity
B856_18310	COG3328	transposase activity
B856_18325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B856_18350	COG1605	Chorismate mutase
B856_18365	COG1309	transcriptional regulator
B856_18375	COG0668	transmembrane transport
B856_18405	COG1301	dicarboxylic acid transport
B856_18425	COG3619	membrane
B856_18430	COG3122	Protein conserved in bacteria
B856_18435	COG1132	(ABC) transporter
B856_18455	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B856_18485	COG1012	belongs to the aldehyde dehydrogenase family
B856_18505	COG0484	heat shock protein binding
B856_18645	COG0741	lytic transglycosylase activity
B856_18680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B856_18835	COG1525	nuclease
B856_18905	COG1475	DNA binding
B856_18925	COG3853	Toxic anion resistance protein (TelA)
B856_18935	COG4372	Transposase
B856_18945	COG2963	transposase activity
B856_19085	COG3173	Aminoglycoside phosphotransferase
B856_19095	COG2433	Pfam Transposase IS66
B856_19130	COG3316	Transposase and inactivated derivatives