locus-tag class description DMO12_00003 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DMO12_00006 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) DMO12_00009 ENOG4105D74 hydrolase DMO12_00015 ENOG4108821 RND type efflux pump DMO12_00018 ENOG4108821 RND type efflux pump DMO12_00021 ENOG4108821 RND type efflux pump DMO12_00024 ENOG4105C5H ABC transporter DMO12_00027 ENOG4105DQR SNARE associated Golgi DMO12_00033 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DMO12_00039 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DMO12_00045 ENOG4105VG0 50S ribosomal protein l34 DMO12_00054 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins DMO12_00063 ENOG4105PGM cation diffusion facilitator family transporter DMO12_00066 ENOG4105T95 Thiol disulfide interChange protein DMO12_00072 ENOG4108UGV hypoxanthine phosphoribosyltransferase DMO12_00078 ENOG4107QUY Guanine deaminase DMO12_00084 ENOG4106032 Glutathionylspermidine synthase DMO12_00093 ENOG4105DU1 integral membrane protein, terc DMO12_00096 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DMO12_00102 ENOG4105DFU Cell wall formation (By similarity) DMO12_00108 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DMO12_00111 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DMO12_00114 ENOG4105CVE Lytic murein transglycosylase DMO12_00147 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) DMO12_00171 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase DMO12_00177 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DMO12_00180 ENOG4105DTN riboflavin biosynthesis protein ribF DMO12_00186 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) DMO12_00189 ENOG4108R86 Transcriptional regulator DMO12_00192 ENOG4108VM9 ABC, transporter DMO12_00195 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DMO12_00198 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DMO12_00201 ENOG4105GVF (ABC) transporter DMO12_00204 ENOG4105GVF (ABC) transporter DMO12_00207 ENOG4107QZM n-acetylglutamate synthase DMO12_00216 ENOG4105UBK short-chain dehydrogenase reductase DMO12_00219 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DMO12_00228 ENOG41062JF Transcriptional regulator DMO12_00243 ENOG4105HSS phospholipase C DMO12_00249 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DMO12_00252 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase DMO12_00255 ENOG4105CJR Integral membrane protein (MviN DMO12_00258 ENOG4108V1T peptidylprolyl cis-trans isomerase DMO12_00261 ENOG4108V1T peptidylprolyl cis-trans isomerase DMO12_00264 ENOG4105D75 Capsular exopolysaccharide family DMO12_00270 ENOG4105DAY polysaccharide export protein DMO12_00273 ENOG4107QQG Dehydrogenase DMO12_00276 ENOG4105C5E polysaccharide biosynthesis protein DMO12_00279 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DMO12_00282 ENOG4105F0R Cytidylyltransferase DMO12_00309 ENOG4108RYC glycosyltransferase DMO12_00312 ENOG4105D3Q Sugar transferase DMO12_00315 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DMO12_00318 ENOG4105C6Y Udp-glucose 6-dehydrogenase DMO12_00324 ENOG4105CMR udp-glucose 4-epimerase DMO12_00327 ENOG4107QKV phosphomannomutase DMO12_00330 ENOG4105DAA L-lactate DMO12_00333 ENOG41073TP transcriptional regulator DMO12_00339 ENOG4105CXG d-lactate dehydrogenase DMO12_00342 ENOG4105CGF Aromatic amino acid aminotransferase DMO12_00345 ENOG4105DRR Transcriptional regulator, GntR family DMO12_00348 ENOG4105CR4 methylisocitrate lyase DMO12_00351 ENOG4105BZN citrate synthase DMO12_00354 ENOG4108I0Z Aconitate hydratase DMO12_00399 ENOG4105D3G Pseudouridine synthase DMO12_00414 ENOG4105EW9 transcriptional regulator AsnC family DMO12_00423 ENOG4105M4H endoribonuclease L-psp DMO12_00426 ENOG4105C85 amino acid DMO12_00429 ENOG4105C85 amino acid DMO12_00435 ENOG4105C26 Dehydrogenase DMO12_00438 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DMO12_00444 ENOG4105C1G acyl-Coa dehydrogenase DMO12_00447 ENOG4105E39 Enoyl-CoA hydratase DMO12_00450 ENOG4105E39 Enoyl-CoA hydratase DMO12_00453 ENOG4105CSH Transporter DMO12_00468 ENOG4105C1G acyl-Coa dehydrogenase DMO12_00492 ENOG4107PSF BolA-like protein DMO12_00498 ENOG4107QJE Chromosome Partitioning Protein DMO12_00507 ENOG4105DQR SNARE associated Golgi DMO12_00510 ENOG4108VBZ doxx family DMO12_00513 ENOG4106MP8 UPF0754 membrane protein DMO12_00516 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DMO12_00528 ENOG4105EUB pirin domain protein DMO12_00543 ENOG4107R1I NAD-dependent malic enzyme DMO12_00546 ENOG4105EZR dyp-type peroxidase family protein DMO12_00552 ENOG4105FAV ABC, transporter DMO12_00555 ENOG4105FDK ABC transporter DMO12_00570 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) DMO12_00591 ENOG41090VV Protein of unknown function (DUF2846) DMO12_00597 ENOG4108V06 Glutathione peroxidase DMO12_00603 ENOG4107RTG Major Facilitator superfamily DMO12_00606 ENOG4108IND Tetr family transcriptional regulator DMO12_00615 ENOG4105C79 DNA protecting protein DprA DMO12_00636 ENOG4105Y7M Transcriptional regulator, TetR family DMO12_00657 ENOG4105C6T cysteine synthase DMO12_00663 ENOG4105CS1 NAD(P)H quinone oxidoreductase DMO12_00675 ENOG4105CCT upf0313 protein DMO12_00684 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DMO12_00690 ENOG4105C0R drug resistance transporter emrb qaca subfamily DMO12_00693 ENOG4108URH decarboxylase DMO12_00696 ENOG4105EE5 Membrane protein terC DMO12_00699 ENOG4105K5B UPF0225 protein DMO12_00702 ENOG4105EN6 Membrane DMO12_00705 ENOG41079KZ Major Facilitator Superfamily DMO12_00708 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DMO12_00711 ENOG4105CEY Amp-dependent synthetase and ligase DMO12_00720 ENOG4105F0N pyrophosphate phospho-hydrolase DMO12_00723 ENOG4105EPF Outer membrane porin DMO12_00756 ENOG4108C33 Resolvase DMO12_00762 ENOG4105W1Y Transcriptional regulator DMO12_00777 ENOG4105CHH sulfate transporter DMO12_00783 ENOG4105C0P Mg chelatase subunit ChlI DMO12_00792 ENOG4105BZU Histidine kinase DMO12_00798 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DMO12_00822 ENOG4108K5H permease YjgP YjgQ family protein DMO12_00825 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DMO12_00828 ENOG4105CN1 protease DMO12_00831 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DMO12_00834 ENOG4107TUY Histidine kinase DMO12_00840 ENOG41061WM D-Alanyl-D-Alanine DMO12_00846 ENOG4105D6E homoserine dehydrogenase DMO12_00849 ENOG4105T95 Thiol disulfide interChange protein DMO12_00852 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DMO12_00858 ENOG4105CE1 Ferrous iron transport protein b DMO12_00867 ENOG4105CNI cell division protein FtsW DMO12_00870 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) DMO12_00873 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters DMO12_00876 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) DMO12_00891 ENOG4108RNG Permease of the drug metabolite transporter DMO12_00894 ENOG4105DFG type I secretion outer membrane protein DMO12_00897 ENOG4108UTW Plays a role in the regulation of phosphate uptake DMO12_00906 ENOG4108HRK Histidine kinase DMO12_00909 ENOG4108NEV two component transcriptional regulator, LytTR family DMO12_00912 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DMO12_00927 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS DMO12_00936 ENOG4105GVR general secretion pathway protein D DMO12_00939 ENOG4105TV9 FHA Domain-Containing protein DMO12_00942 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) DMO12_00966 ENOG4105PM1 preprotein translocase subunit SecE DMO12_00969 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DMO12_00999 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) DMO12_01002 ENOG4105D3Y Na H antiporter DMO12_01011 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DMO12_01020 ENOG4107ZXU DSBA oxidoreductase DMO12_01062 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DMO12_01065 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DMO12_01083 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DMO12_01089 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DMO12_01098 ENOG4105C2N RNA methyltransferase TrmH family group 3 DMO12_01104 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DMO12_01113 ENOG4107QHF type ii secretion system protein e DMO12_01119 ENOG4107EJC Preprotein translocase subunit SecG DMO12_01134 ENOG4105CHV Transcription elongation factor NusA DMO12_01143 ENOG4105KJM monovalent cation h antiporter subunit g DMO12_01146 ENOG4105W4C monovalent cation H antiporter subunit F DMO12_01149 ENOG4105SC1 monovalent cation H antiporter subunit E DMO12_01152 ENOG4107R4Z monovalent cation h antiporter subunit d DMO12_01155 ENOG4108ZE9 Monovalent cation H antiporter subunit C DMO12_01158 ENOG4105D65 subunit l DMO12_01167 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DMO12_01170 ENOG41061H0 Monooxygenase DMO12_01179 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DMO12_01185 ENOG4105CSR polyphosphate kinase 2 DMO12_01191 ENOG4105DSY exodeoxyribonuclease V, gamma DMO12_01194 ENOG4107QKA exodeoxyribonuclease V beta DMO12_01197 ENOG4107QYX exodeoxyribonuclease v alpha DMO12_01209 ENOG4107QUT magnesium and cobalt transport protein CorA DMO12_01212 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) DMO12_01215 ENOG4105DVC DnaJ domain protein DMO12_01221 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DMO12_01224 ENOG4105CKD glutathione-regulated potassium-efflux system protein DMO12_01227 ENOG4105C25 Primosomal protein n' DMO12_01230 ENOG4105D7Q type ii secretion system DMO12_01233 ENOG4108VAU general secretion pathway protein G DMO12_01239 ENOG4108Z7R Chaperone CsaA DMO12_01242 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) DMO12_01245 ENOG4108JU5 Magnesium and cobalt efflux protein DMO12_01248 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) DMO12_01251 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase DMO12_01257 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DMO12_01266 ENOG4105C5X domain protein DMO12_01269 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) DMO12_01293 ENOG4107T8P acyl-Coa dehydrogenase DMO12_01299 ENOG4107QI1 Mate efflux family protein DMO12_01305 ENOG4105CSA Coproporphyrinogen iii oxidase DMO12_01308 ENOG4105EMU Dehydrogenase DMO12_01311 ENOG4105CBN LysR family transcriptional regulator DMO12_01323 ENOG4105C03 ribonuclease DMO12_01326 ENOG4105EI2 Pseudouridine synthase DMO12_01329 ENOG4107XGZ Hydrolase DMO12_01332 ENOG4105D29 Helix-turn-helix type 11 domain protein DMO12_01341 ENOG4108W5M transcriptional regulator DMO12_01350 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase DMO12_01365 ENOG4105DUM transcriptional regulator, lysR family DMO12_01380 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DMO12_01413 ENOG4105CK2 sodium dicarboxylate symporter DMO12_01419 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase DMO12_01422 ENOG4105N14 lysine exporter protein LysE YggA DMO12_01425 ENOG4105C5H ABC transporter DMO12_01428 ENOG41069P5 Protein slyX homolog DMO12_01434 ENOG4105KVH Transcriptional regulator DMO12_01440 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DMO12_01449 ENOG4105C4R Atp-dependent dna helicase DMO12_01452 ENOG4105VFU Rna-binding protein DMO12_01464 ENOG4105CKD glutathione-regulated potassium-efflux system protein DMO12_01467 ENOG4105W0E 50S ribosomal protein L33 DMO12_01470 ENOG4105KDC 50s ribosomal protein l28 DMO12_01473 ENOG4107RGH Aldehyde dehydrogenase DMO12_01479 ENOG4105CIY formyltetrahydrofolate deformylase DMO12_01539 ENOG4105DWV Homoserine O-trans-acetylase DMO12_01545 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DMO12_01551 ENOG4108ESX Receptor DMO12_01557 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DMO12_01569 ENOG4107GFK fumarate DMO12_01572 ENOG4108DNC Involved in acetate metabolism (By similarity) DMO12_01575 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DMO12_01578 ENOG4105C01 Dihydroxy-acid dehydratase DMO12_01581 ENOG4108UHU Aldolase DMO12_01584 ENOG4105C6Z Gluconate DMO12_01587 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family DMO12_01590 ENOG4105C26 Dehydrogenase DMO12_01596 ENOG4106HB6 Alpha beta hydrolase DMO12_01605 ENOG4105CN1 protease DMO12_01614 ENOG4105WVQ Fe-S assembly protein IscX DMO12_01626 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) DMO12_01638 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) DMO12_01650 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) DMO12_01659 ENOG4105CEY Amp-dependent synthetase and ligase DMO12_01668 ENOG4105C84 Histidine ammonia-lyase DMO12_01686 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DMO12_01692 ENOG4105C2D reductase DMO12_01695 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DMO12_01707 ENOG4105VW4 glutaredoxin 3 DMO12_01713 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DMO12_01716 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) DMO12_01722 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DMO12_01725 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DMO12_01728 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) DMO12_01731 ENOG4105DJY efflux transporter, rnd family, mfp subunit DMO12_01746 ENOG4105C7K acetolactate synthase DMO12_01749 ENOG4108ZP8 Acetolactate synthase small subunit DMO12_01755 ENOG4105BZU Histidine kinase DMO12_01767 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) DMO12_01776 ENOG4105F8V Hydrolase, tatD family DMO12_01779 ENOG4107QM5 aconitate hydratase DMO12_01785 ENOG4105CUZ uba thif-type nad fad binding protein DMO12_01788 ENOG4107RSM transcriptional regulator DMO12_01794 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DMO12_01803 ENOG4106UX7 integral membrane protein DMO12_01806 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DMO12_01809 ENOG4105W8H transhydrogenase (subunit alpha DMO12_01812 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) DMO12_01821 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) DMO12_01824 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DMO12_01827 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase DMO12_01830 ENOG4105BZU Histidine kinase DMO12_01833 ENOG4105C6T cysteine synthase DMO12_01842 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DMO12_01848 ENOG4105DXN mazG family DMO12_01851 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein DMO12_01854 ENOG4105DJ0 Poly(A) Polymerase DMO12_01857 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DMO12_01869 ENOG41080Z8 PHOSPHOCARRIER protein DMO12_01872 ENOG4105N42 UPF0307 protein DMO12_01875 ENOG4105CEY Amp-dependent synthetase and ligase DMO12_01884 ENOG4105CYM Glutathione S-transferase DMO12_01887 ENOG4105W39 Membrane DMO12_01896 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DMO12_01911 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DMO12_01920 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DMO12_01926 ENOG4105C9X ppx gppa phosphatase DMO12_01932 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DMO12_01935 ENOG4105II7 pyrroline-5-carboxylate reductase DMO12_01938 ENOG4108VIA integral membrane protein DMO12_01941 ENOG4105C2M dna polymerase I DMO12_01953 ENOG4107QHF type ii secretion system protein e DMO12_01956 ENOG4108ZHJ Organic hydroperoxide resistance protein DMO12_01959 ENOG4105K56 Transcriptional regulator DMO12_02001 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DMO12_02004 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DMO12_02007 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DMO12_02013 ENOG4105CRQ synthase (Component I) DMO12_02040 ENOG4108Z0R Transferase DMO12_02043 ENOG41072GX Peptidase M22 Glycoprotease DMO12_02058 ENOG4105DJV ribulose-phosphate 3-epimerase DMO12_02061 ENOG4108HCJ Hydrolase DMO12_02067 ENOG4105E3B Multicopper oxidase DMO12_02070 ENOG4105VR0 copper resistance DMO12_02079 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DMO12_02082 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DMO12_02085 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DMO12_02106 ENOG4105ETT transcriptional Regulator, LysR family DMO12_02109 ENOG4105C1G acyl-Coa dehydrogenase DMO12_02112 ENOG4107RGD Major Facilitator superfamily DMO12_02115 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F DMO12_02121 ENOG4107EFR Flavocytochrome c DMO12_02124 ENOG4106P55 Transcriptional regulator DMO12_02133 ENOG4106P55 Transcriptional regulator DMO12_02139 ENOG4105CH2 amidohydrolase DMO12_02148 ENOG4105N14 lysine exporter protein LysE YggA DMO12_02151 ENOG4105ETT transcriptional Regulator, LysR family DMO12_02157 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DMO12_02160 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) DMO12_02175 ENOG4105JAB phenazine biosynthesis protein, phzf family DMO12_02181 ENOG4105F9F transposase DMO12_02190 ENOG4105DZG Dehydrogenase DMO12_02232 ENOG4105EB3 Histidine kinase DMO12_02235 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DMO12_02241 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DMO12_02244 ENOG4107EXC regulatoR DMO12_02247 ENOG4105E0F Histidine kinase DMO12_02253 ENOG4105BZU Histidine kinase DMO12_02265 ENOG4105GKE subunit e DMO12_02268 ENOG4107QIZ NADH dehydrogenase DMO12_02271 ENOG4108IEH NADH dehydrogenase subunit g DMO12_02280 ENOG4107UFS subunit j DMO12_02286 ENOG4105D65 subunit l DMO12_02289 ENOG4105C8S subunit m DMO12_02301 ENOG4105DUM transcriptional regulator, lysR family DMO12_02304 ENOG4105DP0 ferredoxin-NADP reductase DMO12_02319 ENOG4105CBX hi0933 family DMO12_02322 ENOG4105K6H D-cysteine desulfhydrase DMO12_02340 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DMO12_02346 ENOG4105D1F ATP-binding protein DMO12_02376 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) DMO12_02382 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY DMO12_02391 ENOG4105HF0 Membrane DMO12_02397 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DMO12_02409 ENOG4106UW1 Major Facilitator superfamily DMO12_02412 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase DMO12_02415 ENOG4108K4C ec 3.1.3.12 DMO12_02418 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DMO12_02424 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DMO12_02427 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) DMO12_02433 ENOG4105FE9 pseudouridine synthase DMO12_02436 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DMO12_02439 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DMO12_02442 ENOG4107RTD sua5 ycio yrdc ywlc family protein DMO12_02445 ENOG4108BPE -transporting atpase DMO12_02448 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein DMO12_02454 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DMO12_02457 ENOG4105CHR reductase DMO12_02463 ENOG4109066 lysm domain bon superfamily protein DMO12_02466 ENOG4105DWF phosphomethylpyrimidine kinase DMO12_02472 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DMO12_02490 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DMO12_02505 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) DMO12_02514 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DMO12_02517 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane DMO12_02520 ENOG4105C34 Pseudouridine synthase DMO12_02523 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DMO12_02535 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding DMO12_02544 ENOG4105EJC lysr family transcriptional regulator DMO12_02547 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DMO12_02550 ENOG4105C94 Transporter DMO12_02556 ENOG4105DVW rieske (2Fe-2S) DMO12_02559 ENOG4105C26 Dehydrogenase DMO12_02562 ENOG4105E3J oxidoreductase DMO12_02571 ENOG4105C4K Nad synthetase DMO12_02577 ENOG4105EUB pirin domain protein DMO12_02580 ENOG4108YXA Membrane DMO12_02607 ENOG4105KEG ribosomal-protein-alanine acetyltransferase DMO12_02613 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) DMO12_02616 ENOG4105C3M thioredoxin reductase DMO12_02619 ENOG4105CNU cell division protein FtsK DMO12_02637 ENOG4107QMS site-determining protein DMO12_02646 ENOG4106HNH Acyl-transferase DMO12_02649 ENOG4108ZG0 Ompa motb domain protein DMO12_02655 ENOG4105C4R Atp-dependent dna helicase DMO12_02661 ENOG4107QKV phosphomannomutase DMO12_02670 ENOG4105E7A Glutamine amidotransferase DMO12_02685 ENOG41090R7 Ferric uptake DMO12_02688 ENOG4105CZX twitching motility protein DMO12_02691 ENOG4105CZX twitching motility protein DMO12_02694 ENOG4105DFA alanine racemase domain protein DMO12_02697 ENOG4105EYH Exonuclease DMO12_02700 ENOG4107RH8 nuclease SbcCD subunit D DMO12_02712 ENOG4105ECP epimerase DMO12_02715 ENOG4105MWK D-amino acid dehydrogenase, small subunit DMO12_02718 ENOG4105D52 delta-aminolevulinic acid dehydratase DMO12_02721 ENOG4108VUY thioesterase Superfamily protein DMO12_02730 ENOG4105C0R drug resistance transporter emrb qaca subfamily DMO12_02733 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DMO12_02754 ENOG4105F9F transposase DMO12_02760 ENOG4105C54 Major Facilitator superfamily DMO12_02763 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DMO12_02769 ENOG4108SF5 RNA Polymerase DMO12_02787 ENOG4108YNN Heme oxygenase DMO12_02802 ENOG4105D5Q Arginine ornithine antiporter DMO12_02805 ENOG4107QK5 Homocysteine s-methyltransferase DMO12_02820 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) DMO12_02823 ENOG4105C94 Transporter DMO12_02826 ENOG4105C94 Transporter DMO12_02838 ENOG4105CKI cobalamin synthesis protein DMO12_02844 ENOG4108VWS Yaeq family DMO12_02850 ENOG4107BJW polysaccharide deacetylase DMO12_02853 ENOG4105CND Glycosyl transferase, family 2 DMO12_02859 ENOG4106YT9 Enoyl-CoA hydratase DMO12_02868 ENOG41069M3 Transcriptional regulator DMO12_02880 ENOG4105CHR reductase DMO12_02886 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase DMO12_02889 ENOG4105DJB Major Facilitator Superfamily DMO12_02895 ENOG4108MXF Alpha Beta Hydrolase DMO12_02898 ENOG4105CHR reductase DMO12_02907 ENOG4105C7K acetolactate synthase DMO12_02913 ENOG4105CSH Transporter DMO12_02919 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DMO12_02922 ENOG4105CSV Glutaminase DMO12_02925 ENOG4108R6W Transcriptional regulator, ARAC family DMO12_02928 ENOG4105EU0 Major facilitator Superfamily DMO12_02931 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) DMO12_02937 ENOG4108PZW LysR family Transcriptional regulator DMO12_02943 ENOG4105CSP Major Facilitator Superfamily DMO12_02952 ENOG4105C3R Methionine synthase DMO12_02955 ENOG4105CJ3 phosphate transporter DMO12_02967 ENOG4105E6M Sulphatase-modifying factor protein DMO12_02970 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) DMO12_02979 ENOG4107RNH Outer membrane receptor FepA DMO12_02991 ENOG4108UJV acyl-CoA thioesterase i DMO12_02994 ENOG4108I0Y (ABC) transporter DMO12_02997 ENOG4105CV6 ABC transporter, permease DMO12_03000 ENOG4107U91 Rhomboid family DMO12_03012 ENOG4105C5Q Transcriptional regulator DMO12_03018 ENOG4107QZF nitrite reductase NADPH large subunit DMO12_03021 ENOG4105VCQ rubredoxin DMO12_03033 ENOG4108MRJ DMO12_03042 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) DMO12_03051 ENOG4105D4T Citrate transporter DMO12_03054 ENOG4105C37 (CBS) domain DMO12_03060 ENOG4107RET Isocitrate lyase DMO12_03078 ENOG4105CQM Urea amidohydrolase subunit alpha DMO12_03084 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) DMO12_03093 ENOG4106H78 methyltransferase DMO12_03096 ENOG4105CJN penicillin-binding protein DMO12_03108 ENOG4105CSM endonuclease III DMO12_03111 ENOG4108R3D Electron transport complex DMO12_03114 ENOG4105D82 Glutamate dehydrogenase DMO12_03120 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b DMO12_03135 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DMO12_03360 ENOG4105DIJ Phosphoethanolamine transferase DMO12_03381 ENOG4107RAQ aminopeptidase DMO12_03384 ENOG4105D0A hydroxylase DMO12_03387 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family DMO12_03399 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DMO12_03402 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) DMO12_03408 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DMO12_03414 ENOG4105W4M Transport-associated protein DMO12_03420 ENOG4105E09 nadh pyrophosphatase DMO12_03426 ENOG4107RZZ dna polymerase iii epsilon subunit DMO12_03429 ENOG4105E9H Lytic Murein transglycosylase DMO12_03429 ENOG4105E9H Lytic Murein transglycosylase DMO12_03435 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component DMO12_03438 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component DMO12_03441 ENOG4108JQ5 ABC transporter DMO12_03453 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) DMO12_03465 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DMO12_03477 ENOG4108M3P Membrane DMO12_03480 ENOG4105D01 (LipO)protein DMO12_03492 ENOG4105CNA YD repeat protein DMO12_03516 ENOG4105C85 amino acid DMO12_03522 ENOG4105CUB amino acid DMO12_03534 ENOG4105C26 Dehydrogenase DMO12_03546 ENOG4105C85 amino acid DMO12_03549 ENOG4107RGH Aldehyde dehydrogenase DMO12_03570 ENOG4105F95 Monooxygenase DMO12_03576 ENOG4105C7N Xanthine uracil vitamin C permease DMO12_03579 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) DMO12_03582 ENOG4105CPW cytochrome b561 DMO12_03588 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DMO12_03594 ENOG4105CFH Aspartokinase DMO12_03600 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DMO12_03606 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DMO12_03615 ENOG4105CPC Aldo Keto reductase DMO12_03618 ENOG4107RYR Transcriptional regulator, Crp Fnr family DMO12_03621 ENOG4108UKZ OsmC family DMO12_03630 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DMO12_03648 ENOG4105CD3 dihydroorotase DMO12_03651 ENOG4108ZG0 Ompa motb domain protein DMO12_03657 ENOG4108TGY Glutathione S-transferase DMO12_03660 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DMO12_03666 ENOG4108K3A Glutathione S-transferase DMO12_03672 ENOG4108JU3 Alkyl hydroperoxide reductase DMO12_03678 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) DMO12_03684 ENOG4105D3R alkyl hydroperoxide reductase DMO12_03687 ENOG4105CQ7 ATP-dependent helicase DMO12_03696 ENOG4105D2S major facilitator superfamily DMO12_03699 ENOG4105DKK Benzoate DMO12_03702 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase DMO12_03705 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein DMO12_03708 ENOG4108UKV benzoate 1,2-dioxygenase DMO12_03711 ENOG4105FUY alpha subunit DMO12_03714 ENOG4108KB2 LysR family Transcriptional regulator DMO12_03744 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DMO12_03765 ENOG410829K Lysine exporter protein (Lyse ygga) DMO12_03768 ENOG4105VEQ Cold shock protein DMO12_03774 ENOG4105II7 pyrroline-5-carboxylate reductase DMO12_03792 ENOG4107YPT transcriptional regulator DMO12_03813 ENOG4105C2X Arabinose 5-phosphate isomerase DMO12_03816 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase DMO12_03822 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA DMO12_03825 ENOG4108IUZ ABC transporter DMO12_03828 ENOG4105DFG type I secretion outer membrane protein DMO12_03852 ENOG4108Z4U Ferredoxin DMO12_03870 ENOG4107AQZ Membrane DMO12_03873 ENOG4105BZU Histidine kinase DMO12_03876 ENOG4105D1S lipid A biosynthesis DMO12_03882 ENOG4105D2S major facilitator superfamily DMO12_03894 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) DMO12_03912 ENOG4105CNA YD repeat protein DMO12_03921 ENOG4108WAV Transcriptional regulator DMO12_03924 ENOG4105C5A transporter DMO12_03936 ENOG4108JIK carboxylase DMO12_03939 ENOG4107R4J Chloride channel DMO12_03954 ENOG4105R8C Transcriptional regulator DMO12_03960 ENOG4105E2A Dehydrogenase DMO12_03969 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DMO12_03972 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF DMO12_03975 ENOG4105KVH Transcriptional regulator DMO12_03984 ENOG4105MRR Transcriptional regulator (By similarity) DMO12_03990 ENOG4108HW3 (ABC) transporter DMO12_04035 ENOG4105UYK outer membrane protein a DMO12_04041 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DMO12_04059 ENOG4105EMY transcriptional regulator DMO12_04065 ENOG4107Y2X deaminase DMO12_04068 ENOG4105DJ2 Major Facilitator Superfamily DMO12_04077 ENOG4105WPN DNA integration recombination invertion protein DMO12_04083 ENOG4108Z4X TRANSCRIPTIONal DMO12_04092 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DMO12_04104 ENOG4105MWK D-amino acid dehydrogenase, small subunit DMO12_04119 ENOG4105CZJ Aldehyde dehydrogenase DMO12_04122 ENOG4107QTZ amino acid DMO12_04125 ENOG4105EJQ L-serine dehydratase DMO12_04128 ENOG4105DXM phenylacetic acid degradation protein DMO12_04131 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit DMO12_04134 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit DMO12_04137 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit DMO12_04140 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit DMO12_04143 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DMO12_04146 ENOG4105E39 Enoyl-CoA hydratase DMO12_04149 ENOG4108UKI Enoyl-CoA hydratase DMO12_04152 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DMO12_04155 ENOG4105CHU acetyl-coa acetyltransferase DMO12_04158 ENOG4105DZS Phenylacetate-CoA ligase DMO12_04161 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein DMO12_04167 ENOG4107YAU phenylacetic acid degradation protein DMO12_04188 ENOG4107VGR Catalase DMO12_04191 ENOG4105CPW cytochrome b561 DMO12_04203 ENOG4108MXF Alpha Beta Hydrolase DMO12_04206 ENOG4105MXW flavin reductase domain protein, FMN-binding DMO12_04209 ENOG4108M8W Monooxygenase DMO12_04212 ENOG4105C26 Dehydrogenase DMO12_04215 ENOG4105ETS cytosine purines uracil thiamine allantoin DMO12_04221 ENOG4105C26 Dehydrogenase DMO12_04224 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DMO12_04227 ENOG4105HEI LysR family (Transcriptional regulator DMO12_04233 ENOG4107HP6 Transcriptional regulator DMO12_04236 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase DMO12_04242 ENOG4105C4Y ABC transporter DMO12_04245 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) DMO12_04248 ENOG4107RCV ABC transporter, permease DMO12_04254 ENOG4107STF Involved in phosphonate degradation (By similarity) DMO12_04257 ENOG4108KAZ Involved in phosphonate degradation (By similarity) DMO12_04260 ENOG4107RGD Major Facilitator superfamily DMO12_04263 ENOG4105C1G acyl-Coa dehydrogenase DMO12_04272 ENOG4108UKI Enoyl-CoA hydratase DMO12_04275 ENOG4105EA8 2-Nitropropane dioxygenase DMO12_04278 ENOG4105EQ0 Major Facilitator superfamily DMO12_04284 ENOG4105CHU acetyl-coa acetyltransferase DMO12_04287 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DMO12_04290 ENOG4105CHR reductase DMO12_04293 ENOG4105E39 Enoyl-CoA hydratase DMO12_04296 ENOG4105C1G acyl-Coa dehydrogenase DMO12_04299 ENOG4107RGD Major Facilitator superfamily DMO12_04302 ENOG4107QP7 CoA-transferase subunit A DMO12_04305 ENOG4107QNJ CoA-transferase subunit B DMO12_04311 ENOG4105EQ0 Major Facilitator superfamily DMO12_04317 ENOG4105CSU acyl-Coa dehydrogenase DMO12_04326 ENOG4105CC0 LysR family Transcriptional regulator DMO12_04335 ENOG4105E39 Enoyl-CoA hydratase DMO12_04338 ENOG4107QX3 carboxylase DMO12_04341 ENOG4105C1G acyl-Coa dehydrogenase DMO12_04344 ENOG4105R8C Transcriptional regulator DMO12_04347 ENOG4105CEY Amp-dependent synthetase and ligase DMO12_04359 ENOG4105HEI LysR family (Transcriptional regulator DMO12_04392 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DMO12_04404 ENOG4105KT5 UmuD protein DMO12_04410 ENOG4105EW9 transcriptional regulator AsnC family DMO12_04416 ENOG4105BZU Histidine kinase DMO12_04419 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase DMO12_04425 ENOG4105EAD ABC transporter DMO12_04428 ENOG4108HW4 amino acid AbC transporter DMO12_04431 ENOG4105CDA abc transporter atp-binding protein DMO12_04434 ENOG4107RP9 extracellular solute-binding protein, family 3 DMO12_04437 ENOG4105CT1 (ABC) transporter DMO12_04440 ENOG4105EXG Transcriptional regulator DMO12_04446 ENOG4105C9B Cysteine desulfurase DMO12_04449 ENOG4105ESN nucleotide-binding protein DMO12_04452 ENOG4105D7W serine acetyltransferase DMO12_04458 ENOG4105CHR reductase DMO12_04461 ENOG4105CBN LysR family transcriptional regulator DMO12_04464 ENOG4105CYM Glutathione S-transferase DMO12_04467 ENOG4108SHQ Glutathione S-transferase DMO12_04470 ENOG4105CMU LysR family (Transcriptional regulator DMO12_04473 ENOG4105VAW lrga family DMO12_04476 ENOG41067MG lrgb family DMO12_04488 ENOG4105DXI Major Facilitator superfamily DMO12_04494 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase DMO12_04497 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) DMO12_04506 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase DMO12_04509 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DMO12_04518 ENOG4108K70 Transcriptional regulator DMO12_04521 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DMO12_04527 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DMO12_04530 ENOG4105C4M (Ubiquinol oxidase) subunit I DMO12_04542 ENOG4105C54 Major Facilitator superfamily DMO12_04548 ENOG4106FTQ Taurine ABC transporter, periplasmic DMO12_04551 ENOG4108IY8 ABC, transporter DMO12_04554 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component DMO12_04557 ENOG4105E2B Taurine dioxygenase DMO12_04563 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DMO12_04569 ENOG4105CBN LysR family transcriptional regulator DMO12_04575 ENOG4105CPN adenine deaminase DMO12_04584 ENOG41082YX Transcriptional regulator, arsr family DMO12_04587 ENOG4105D6J arsenicaL-resistance protein DMO12_04590 ENOG4108KB2 LysR family Transcriptional regulator DMO12_04599 ENOG4108JU3 Alkyl hydroperoxide reductase DMO12_04614 ENOG4105C0B DNA polymerase III (alpha subunit) DMO12_04623 ENOG4105CHM Aminotransferase DMO12_04629 ENOG4108V06 Glutathione peroxidase DMO12_04632 ENOG4105E7U AraC family transcriptional regulator DMO12_04650 ENOG4105ZED uncharacterized protein ygaH DMO12_04653 ENOG4108UMN azlc family DMO12_04668 ENOG4105C3G gtp-binding protein DMO12_04671 ENOG4108UMI ABC transporter, permease DMO12_04674 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DMO12_04677 ENOG4105D01 (LipO)protein DMO12_04680 ENOG4105D01 (LipO)protein DMO12_04689 ENOG4107T8P acyl-Coa dehydrogenase DMO12_04698 ENOG4105EAD ABC transporter DMO12_04701 ENOG4105DRP amino acid AbC transporter DMO12_04704 ENOG4105CDA abc transporter atp-binding protein DMO12_04710 ENOG4105EW9 transcriptional regulator AsnC family DMO12_04719 ENOG41067SE Tetr family transcriptional regulator DMO12_04734 ENOG4105CC0 LysR family Transcriptional regulator DMO12_04740 ENOG4105ETS cytosine purines uracil thiamine allantoin DMO12_04746 ENOG4108IPJ Membrane DMO12_04761 ENOG4105GQR Chaperone DMO12_04764 ENOG4105X0I Fimbrial DMO12_04776 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DMO12_04779 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DMO12_04791 ENOG4108HWY Beta-lactamase DMO12_04806 ENOG4105CV1 Transketolase (EC 2.2.1.1) DMO12_04812 ENOG4108YYC ycei family DMO12_04818 ENOG4108T58 Mg2 transport protein CorA DMO12_04827 ENOG4105YGK Pfam:UPF0157 DMO12_04830 ENOG4105C26 Dehydrogenase DMO12_04833 ENOG4105EW9 transcriptional regulator AsnC family DMO12_04836 ENOG4105CK7 Sodium proline symporter DMO12_04839 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DMO12_04845 ENOG4108ZX5 transcriptional regulator DMO12_04851 ENOG4105BZ1 (ABC) transporter DMO12_04854 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme DMO12_04857 ENOG4105XPP Protein of unknown function (DUF1275) DMO12_04863 ENOG41080HT Transcriptional regulator, arsr family DMO12_04869 ENOG4105EZE Cupin 4 family protein DMO12_04872 ENOG4108UHJ MAF-like protein DMO12_04884 ENOG4105D2N Aldolase DMO12_04887 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DMO12_04890 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) DMO12_04893 ENOG4105EHM Aminoglycoside phosphotransferase DMO12_04896 ENOG4108S0S Nucleotidyl transferase DMO12_04902 ENOG4107QJE Chromosome Partitioning Protein DMO12_04905 ENOG4105FA0 parb-like partition protein DMO12_04914 ENOG4105BZ1 (ABC) transporter DMO12_04917 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) DMO12_04923 ENOG4107QRG dna polymerase iii DMO12_04929 ENOG4105F8V Hydrolase, tatD family DMO12_04944 ENOG4108RTD type II secretion system protein K DMO12_04956 ENOG4108Z6B deaminase DMO12_04965 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DMO12_04968 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) DMO12_04980 ENOG4107RN6 Monooxygenase DMO12_04986 ENOG4105D6Z AFG1 family ATPase DMO12_04989 ENOG4107QP3 malate synthase g DMO12_04995 ENOG4105SG9 biopolymer transport protein, ExbD DMO12_05019 ENOG4105DGW oligopeptidase A DMO12_05025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DMO12_05037 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase DMO12_05046 ENOG4105K4T epimerase DMO12_05049 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) DMO12_05061 ENOG4108JA2 transcriptioN-repair coupling factor DMO12_05067 ENOG4105F8J Adenylate Guanylate cyclase DMO12_05073 ENOG4108ZIT Ferredoxin, 2FE-2S DMO12_05082 ENOG4108Z4V iron-sulfur cluster assembly DMO12_05085 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins DMO12_05091 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family DMO12_05100 ENOG4105K70 DNA-binding protein DMO12_05103 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) DMO12_05106 ENOG4105E7U AraC family transcriptional regulator DMO12_05109 ENOG4105EEF Alkane 1-monooxygenase DMO12_05112 ENOG4105C1G acyl-Coa dehydrogenase DMO12_05115 ENOG4105C1G acyl-Coa dehydrogenase DMO12_05124 ENOG4108Z66 YbaK ebsC protein DMO12_05136 ENOG4105DUU IucA IucC family protein DMO12_05139 ENOG4105DJU Siderophore biosynthesis protein DMO12_05163 ENOG4107VXZ Hydrolase DMO12_05169 ENOG4108YZT Adenosylcobinamide kinase DMO12_05172 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) DMO12_05184 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DMO12_05187 ENOG4107TSN permease DMO12_05199 ENOG4105CNM Receptor DMO12_05202 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DMO12_05211 ENOG4105CJ1 ABC, transporter DMO12_05214 ENOG4107QWP ABC-2 type transporter DMO12_05217 ENOG4107QWP ABC-2 type transporter DMO12_05232 ENOG4105K59 histidine triad (HIT) protein DMO12_05250 ENOG4105F2W methyltransferase DMO12_05256 ENOG4105C28 cystathionine DMO12_05265 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DMO12_05292 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DMO12_05295 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) DMO12_05301 ENOG4105BZU Histidine kinase DMO12_05310 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DMO12_05313 ENOG4107R0V Pyruvate dehydrogenase DMO12_05316 ENOG4105CPP Dehydrogenase, E1 component DMO12_05325 ENOG4105CHR reductase DMO12_05331 ENOG4105FFC UPF0187 protein DMO12_05337 ENOG4107QPB Beta-lactamase domain protein DMO12_05343 ENOG4108VCT Sulfite exporter TauE/SafE DMO12_05352 ENOG4105UEI Transcriptional Regulator AraC Family DMO12_05355 ENOG4105KVH Transcriptional regulator DMO12_05358 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DMO12_05364 ENOG4105FDP GntR family transcriptional regulator DMO12_05373 ENOG4106FTQ Taurine ABC transporter, periplasmic DMO12_05376 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DMO12_05388 ENOG4105CSH Transporter DMO12_05394 ENOG4108IJ0 Aspartate ammonia-lyase DMO12_05403 ENOG4107YNJ LysR family Transcriptional regulator DMO12_05409 ENOG4105CHU acetyl-coa acetyltransferase DMO12_05412 ENOG4105CRW Short chain fatty acid transporter DMO12_05415 ENOG4107QNJ CoA-transferase subunit B DMO12_05421 ENOG4108M0I Transcriptional regulator DMO12_05427 ENOG4105CY2 Citrate transporter DMO12_05430 ENOG4105DTD Dehydrogenase DMO12_05433 ENOG4105CF7 AraC family transcriptional regulator DMO12_05436 ENOG4105D2S major facilitator superfamily DMO12_05442 ENOG4105CHR reductase DMO12_05457 ENOG4105F57 Anthranilate dioxygenase reductase DMO12_05460 ENOG4108YS2 small subunit DMO12_05463 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit DMO12_05466 ENOG4105F4R Transcriptional regulator mode DMO12_05469 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DMO12_05472 ENOG4105E0C molybdate abc transporter DMO12_05475 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) DMO12_05478 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DMO12_05481 ENOG4105WQI isochorismatase DMO12_05487 ENOG4107T31 5'-nucleotidase DMO12_05505 ENOG4108IGT Dipeptidase DMO12_05517 ENOG4107RZC phospholipase d DMO12_05547 ENOG4105X0I Fimbrial DMO12_05559 ENOG4105CJP fad dependent oxidoreductase DMO12_05571 ENOG4105CT3 Monooxygenase DMO12_05577 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DMO12_05580 ENOG4105BZS acriflavin resistance protein DMO12_05583 ENOG4105C1P efflux transporter, rnd family, mfp subunit DMO12_05586 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DMO12_05589 ENOG4105E0F Histidine kinase DMO12_05592 ENOG4108821 RND type efflux pump DMO12_05595 ENOG4108R6W Transcriptional regulator, ARAC family DMO12_05604 ENOG4108BAS reductase DMO12_05637 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) DMO12_05661 ENOG4108UAJ Transcriptional regulator DMO12_05709 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DMO12_05721 ENOG4105E0A ABC, transporter DMO12_05724 ENOG4105EHG Permease protein DMO12_05730 ENOG4105DQ4 alcohol dehydrogenase DMO12_05739 ENOG4105CF7 AraC family transcriptional regulator DMO12_05742 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DMO12_05748 ENOG4105EXW epimerase dehydratase DMO12_05751 ENOG4105DDW LysR family Transcriptional regulator DMO12_05757 ENOG4105C01 Dihydroxy-acid dehydratase DMO12_05760 ENOG4105CZJ Aldehyde dehydrogenase DMO12_05769 ENOG4105CW7 secretion protein, HlyD family DMO12_05781 ENOG4105JSC dimethylmenaquinone methyltransferase DMO12_05784 ENOG4108JQ1 Dehydrogenase DMO12_05799 ENOG4106KR7 LysR family Transcriptional regulator DMO12_05808 ENOG4105FDP GntR family transcriptional regulator DMO12_05826 ENOG4105CKT filamentous hemagglutinin DMO12_05829 ENOG4105D5K Hemolysin activator protein DMO12_05835 ENOG4105CH2 amidohydrolase DMO12_05841 ENOG4105CKD glutathione-regulated potassium-efflux system protein DMO12_05844 ENOG4105D8V Glucose sorbosone dehydrogenase DMO12_05847 ENOG4105EJC lysr family transcriptional regulator DMO12_05850 ENOG4105CHJ isochorismatase hydrolase DMO12_05856 ENOG4107Z3H Transcriptional regulator, TetR family DMO12_05874 ENOG4105NAE bifunctional deaminase-reductase domain protein DMO12_05880 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DMO12_05883 ENOG4105K56 Transcriptional regulator DMO12_05895 ENOG4105CH6 catalase DMO12_05904 ENOG4107RGH Aldehyde dehydrogenase DMO12_05913 ENOG41062QD Membrane DMO12_05919 ENOG4108JU7 Transcriptional regulator DMO12_05922 ENOG4105CHR reductase DMO12_05925 ENOG4105C1G acyl-Coa dehydrogenase DMO12_05937 ENOG4105CZJ Aldehyde dehydrogenase DMO12_05949 ENOG4107EJG GntR family transcriptional regulator DMO12_05955 ENOG4108KB2 LysR family Transcriptional regulator DMO12_05958 ENOG4105DTQ mandelate racemase muconate lactonizing DMO12_05961 ENOG4105NN7 muconolactone delta-isomerase DMO12_05967 ENOG4107QP7 CoA-transferase subunit A DMO12_05970 ENOG4107QNJ CoA-transferase subunit B DMO12_05973 ENOG4105CHU acetyl-coa acetyltransferase DMO12_05976 ENOG4105F2Z 3-oxoadipate enol-lactonase DMO12_05982 ENOG4105C26 Dehydrogenase DMO12_05988 ENOG4105F11 amine oxidase DMO12_06000 ENOG4105CHR reductase DMO12_06006 ENOG4105FUY alpha subunit DMO12_06018 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DMO12_06024 ENOG4105DNH Major Facilitator DMO12_06039 ENOG4105C1G acyl-Coa dehydrogenase DMO12_06042 ENOG4108PTX LysR family Transcriptional regulator DMO12_06045 ENOG4107HP6 Transcriptional regulator DMO12_06054 ENOG4105MD1 YeeE YedE family protein DMO12_06060 ENOG4105DZG Dehydrogenase DMO12_06063 ENOG4105TW1 Carbohydrate-selective porin OprB DMO12_06066 ENOG4106JPM 3-dehydroshikimate dehydratase DMO12_06069 ENOG4105FF2 Type I DHQase DMO12_06072 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha DMO12_06075 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta DMO12_06078 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase DMO12_06081 ENOG4105D2S major facilitator superfamily DMO12_06084 ENOG4105F2Z 3-oxoadipate enol-lactonase DMO12_06087 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase DMO12_06090 ENOG4105CHU acetyl-coa acetyltransferase DMO12_06093 ENOG4107QNJ CoA-transferase subunit B DMO12_06096 ENOG4107QP7 CoA-transferase subunit A DMO12_06102 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) DMO12_06105 ENOG4107VMU Membrane DMO12_06132 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DMO12_06141 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) DMO12_06147 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit DMO12_06150 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) DMO12_06168 ENOG4105C7B Threonine dehydratase DMO12_06174 ENOG4105CZN Potassium uptake protein DMO12_06177 ENOG4105HDD phospholipase DMO12_06183 ENOG4105E0K tonB-dependent siderophore receptor DMO12_06192 ENOG4105PV3 Inner membrane protein yqiJ DMO12_06204 ENOG4105C4M (Ubiquinol oxidase) subunit I DMO12_06207 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DMO12_06219 ENOG41068P6 UPF0319 protein DMO12_06225 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DMO12_06240 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DMO12_06243 ENOG4105C8Y Acetylornithine aminotransferase DMO12_06246 ENOG4105M2J Glutaredoxin DMO12_06252 ENOG4105CC0 LysR family Transcriptional regulator DMO12_06255 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DMO12_06258 ENOG4105CWM branched-chain amino acid transport system II carrier protein DMO12_06273 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DMO12_06276 ENOG4105DE4 1-phosphofructokinase DMO12_06279 ENOG4105DM4 PTS System DMO12_06294 ENOG4105BZU Histidine kinase DMO12_06300 ENOG4105D8V Glucose sorbosone dehydrogenase DMO12_06303 ENOG4108RAV Conserved protein DMO12_06306 ENOG4105CHH sulfate transporter DMO12_06315 ENOG4105F9F transposase DMO12_06318 ENOG4105C85 amino acid DMO12_06324 ENOG4105F7P transcriptional regulator AsnC family DMO12_06339 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 DMO12_06342 ENOG4105VEJ Heat shock protein DMO12_06348 ENOG4105Y3E Modulates RecA activity (By similarity) DMO12_06354 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) DMO12_06369 ENOG4105DZP Membrane-associated zinc metalloprotease DMO12_06375 ENOG4105KNE Phosphatidate cytidylyltransferase DMO12_06378 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DMO12_06390 ENOG4105CUX Signal transduction histidine kinase DMO12_06393 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DMO12_06426 ENOG4105CMR udp-glucose 4-epimerase DMO12_06429 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) DMO12_06441 ENOG4105T38 integral membrane protein DMO12_06444 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DMO12_06450 ENOG4105CVM Molybdenum cofactor synthesis domain protein DMO12_06453 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DMO12_06462 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DMO12_06474 ENOG4108IFG nitrite reductase, (NAD(P)H) DMO12_06477 ENOG4107QZF nitrite reductase NADPH large subunit DMO12_06483 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DMO12_06495 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein DMO12_06498 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DMO12_06504 ENOG4105D8G Major Facilitator superfamily DMO12_06567 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DMO12_06591 ENOG4105K4U addiction module toxin, RelE StbE family DMO12_06759 ENOG41083X2 DNA polymerase III, epsilon subunit DMO12_06798 ENOG4105CBC glutamate synthase DMO12_06816 ENOG4105C0A alcohol dehydrogenase DMO12_06822 ENOG4105HSS phospholipase C DMO12_06828 ENOG4107QMP dna polymerase iii subunits gamma and tau DMO12_06843 ENOG4105CHR reductase DMO12_06846 ENOG4105CHU acetyl-coa acetyltransferase DMO12_06852 ENOG4105C5Q Transcriptional regulator DMO12_06855 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) DMO12_06858 ENOG4108NIW Leucine export protein LeuE DMO12_06861 ENOG4105EW9 transcriptional regulator AsnC family DMO12_06864 ENOG4105DKK Benzoate DMO12_06870 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic DMO12_06885 ENOG41081QV Universal stress protein DMO12_06888 ENOG4105C5H ABC transporter DMO12_06900 ENOG4105CNM Receptor DMO12_06918 ENOG4105CUY Mechanosensitive ion channel DMO12_06924 ENOG4105R8C Transcriptional regulator DMO12_06930 ENOG4105EW9 transcriptional regulator AsnC family DMO12_06933 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) DMO12_06939 ENOG4105EMU Dehydrogenase DMO12_06945 ENOG4105CD8 aminopeptidase N DMO12_06957 ENOG4105F4I Transcriptional regulator DMO12_06963 ENOG4107QUV Domain protein DMO12_06966 ENOG4105C0A alcohol dehydrogenase DMO12_06972 ENOG4107RR1 TRANSCRIPTIONal DMO12_06978 ENOG4107R55 ethanolamine transporter DMO12_06981 ENOG4105CPD ethanolamine ammonia-lyase DMO12_06984 ENOG4107FQ9 ethanolamine ammonia-lyase DMO12_06987 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) DMO12_06996 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) DMO12_07002 ENOG4108RCM Nitroreductase DMO12_07005 ENOG4108TZV Membrane DMO12_07008 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DMO12_07014 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DMO12_07017 ENOG4105K8N protein family UPF0079, ATPase DMO12_07038 ENOG4105DZ2 Transcriptional regulator DMO12_07047 ENOG4105F27 Major Facilitator DMO12_07050 ENOG4105EYW Ion transport protein DMO12_07056 ENOG4107QIJ Aconitate hydratase 2 DMO12_07065 ENOG4105CFU surface antigen DMO12_07068 ENOG4107S74 Lysophospholipid transporter LplT DMO12_07077 ENOG4105CFQ glutamine synthetase DMO12_07080 ENOG4105EEX Two component transcriptional regulator (Winged helix family DMO12_07083 ENOG4105C08 Histidine kinase DMO12_07089 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DMO12_07092 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) DMO12_07104 ENOG4105D06 uba thif-type nad fad binding protein DMO12_07107 ENOG4108MEJ flavin reductase domain protein DMO12_07113 ENOG4105C1G acyl-Coa dehydrogenase DMO12_07122 ENOG4105GVF (ABC) transporter DMO12_07125 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DMO12_07128 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DMO12_07137 ENOG4105CC0 LysR family Transcriptional regulator DMO12_07146 ENOG4105DEN Luciferase family DMO12_07152 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD DMO12_07155 ENOG4105CND Glycosyl transferase, family 2 DMO12_07158 ENOG4107BJW polysaccharide deacetylase DMO12_07176 ENOG4105E2S oxidase) subunit II DMO12_07179 ENOG4105BZ9 Cytochrome C oxidase, subunit I DMO12_07182 ENOG4105CCU oxidase (Subunit III) DMO12_07185 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) DMO12_07200 ENOG4105CDU Replicative dna helicase DMO12_07203 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DMO12_07233 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) DMO12_07236 ENOG4105DC1 bifunctional purine biosynthesis protein purh DMO12_07239 ENOG4105C12 Phosphoribosylglycinamide synthetase DMO12_07245 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DMO12_07248 ENOG4108UMI ABC transporter, permease DMO12_07251 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) DMO12_07257 ENOG4105CK2 sodium dicarboxylate symporter DMO12_07281 ENOG4105DY2 Paraquat-inducible protein b DMO12_07284 ENOG4105F1S paraquat-inducible protein a DMO12_07293 ENOG4105CEB Aspartate aminotransferase DMO12_07302 ENOG4105CSH Transporter DMO12_07305 ENOG4105CSH Transporter DMO12_07326 ENOG4105F9F transposase DMO12_07338 ENOG4105JXH GntR family transcriptional regulator DMO12_07344 ENOG4105D6U Sodium Glutamate Symporter DMO12_07362 ENOG4105H4F exported protein DMO12_07383 ENOG4105C26 Dehydrogenase DMO12_07386 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DMO12_07389 ENOG4105EVZ LysR family transcriptional regulator DMO12_07404 ENOG4105D9P serine threonine protein kinase DMO12_07419 ENOG4105VCC 30S ribosomal protein S21 DMO12_07422 ENOG4105KTH gatB Yqey DMO12_07425 ENOG4105ERG peptidase m48, ste24p DMO12_07428 ENOG4105C5I Dehydrogenase DMO12_07437 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase DMO12_07458 ENOG41069NU Nitroreductase DMO12_07464 ENOG4105C1J atp-dependent rna helicase DMO12_07467 ENOG4105VEQ Cold shock protein DMO12_07473 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DMO12_07476 ENOG4105M08 Membrane DMO12_07494 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DMO12_07497 ENOG4105CIN aminoacyl-histidine dipeptidase DMO12_07503 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DMO12_07506 ENOG4105CQC Prephenate dehydratase DMO12_07509 ENOG4105NIV Esterase DMO12_07512 ENOG4105C1G acyl-Coa dehydrogenase DMO12_07515 ENOG4105CK2 sodium dicarboxylate symporter DMO12_07518 ENOG4107QYG anthranilate phosphoribosyltransferase DMO12_07521 ENOG4105VUT cytoplasmic protein DMO12_07524 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DMO12_07527 ENOG4105BZ4 penicillin-binding protein DMO12_07533 ENOG4105M6F mutator MutT protein DMO12_07539 ENOG4105DHQ Histidine kinase DMO12_07542 ENOG4105XJC Two component transcriptional regulator (Winged helix family DMO12_07548 ENOG4107QHF type ii secretion system protein e DMO12_07554 ENOG4108R96 Methyltransferase, YaeB family DMO12_07557 ENOG4105DP0 ferredoxin-NADP reductase DMO12_07560 ENOG4105JAB phenazine biosynthesis protein, phzf family DMO12_07563 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DMO12_07566 ENOG4105CFP Peptidase U32 DMO12_07569 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding DMO12_07575 ENOG4108JEH abc transporter atp-binding protein DMO12_07578 ENOG4106YG3 ABC transporter DMO12_07581 ENOG4105DSP amino acid AbC transporter DMO12_07584 ENOG4105E89 ABC transporter DMO12_07590 ENOG4105ENT Efflux transporter rnd family, mfp subunit DMO12_07596 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DMO12_07617 ENOG4105DA5 (ABC) transporter DMO12_07620 ENOG4105E3A (ABC) transporter DMO12_07629 ENOG4105CNI cell division protein FtsW DMO12_07632 ENOG4105CVE Lytic murein transglycosylase DMO12_07656 ENOG4105CE9 30S ribosomal protein S2 DMO12_07659 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DMO12_07665 ENOG4107RNU major facilitator superfamily MFS_1 DMO12_07674 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) DMO12_07677 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DMO12_07680 ENOG4107QPN acyl-Coa dehydrogenase DMO12_07689 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) DMO12_07692 ENOG4105SYT Methylenetetrahydrofolate reductase DMO12_07695 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DMO12_07698 ENOG4105BZU Histidine kinase DMO12_07701 ENOG4105C6K Malic enzyme DMO12_07707 ENOG4105C0H protease DMO12_07710 ENOG4107QNR UPF0135 protein DMO12_07713 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DMO12_07734 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) DMO12_07740 ENOG4105C5F glutamine synthetase DMO12_07743 ENOG4105DUX Transporter DMO12_07749 ENOG4105DDQ anthranilate synthase DMO12_07752 ENOG4105CD8 aminopeptidase N DMO12_07770 ENOG4105C7W Xanthine dehydrogenase DMO12_07776 ENOG4105EUJ GTP cyclohydrolase i DMO12_07779 ENOG4105F9F transposase DMO12_07791 ENOG4105NX3 Membrane DMO12_07800 ENOG4105E4F Isochorismate synthase DMO12_07812 ENOG4105BZ1 (ABC) transporter DMO12_07821 ENOG4105WQI isochorismatase DMO12_07824 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DMO12_07827 ENOG4105C0W non-ribosomal peptide synthetase DMO12_07839 ENOG4108IPW abc transporter atp-binding protein DMO12_07854 ENOG4105CEY Amp-dependent synthetase and ligase DMO12_07863 ENOG4105WWK YheO domain protein DMO12_07872 ENOG4105C2I pirin domain protein DMO12_07881 ENOG4105J7D transcriptional regulator DMO12_07887 ENOG4107WEA mandelate racemase muconate lactonizing DMO12_07890 ENOG4107QNK )-transporter DMO12_07893 ENOG41060M8 Pfam:PhdYeFM DMO12_07911 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) DMO12_07914 ENOG4107QZF nitrite reductase NADPH large subunit DMO12_07917 ENOG4105C26 Dehydrogenase DMO12_07923 ENOG4105C94 Transporter DMO12_07926 ENOG4105C94 Transporter DMO12_07929 ENOG4105ETT transcriptional Regulator, LysR family DMO12_07932 ENOG4105C85 amino acid DMO12_07935 ENOG4105C26 Dehydrogenase DMO12_07944 ENOG4108K8K Transcriptional regulator DMO12_07965 ENOG4105VCD cytoplasmic protein DMO12_07968 ENOG4105D22 carbon starvation protein DMO12_07974 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DMO12_07989 ENOG4105DHU Bile acid DMO12_07998 ENOG4105DAN ATP-dependent protease DMO12_08001 ENOG4105EJC lysr family transcriptional regulator DMO12_08004 ENOG4108K5P (LipO)protein DMO12_08016 ENOG4105DZ1 carboxypeptidase DMO12_08019 ENOG4108Z0R Transferase DMO12_08031 ENOG4107QTF adenylosuccinate lyase DMO12_08040 ENOG4105ERU peptidase DMO12_08043 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DMO12_08049 ENOG4105C8U phosphate abc transporter DMO12_08052 ENOG4105CVA phosphate DMO12_08055 ENOG4105C85 amino acid DMO12_08058 ENOG4107RA9 decarboxylase DMO12_08061 ENOG4105F7P transcriptional regulator AsnC family DMO12_08067 ENOG4105DY8 decarboxylase DMO12_08070 ENOG4108JPW Aminotransferase DMO12_08085 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DMO12_08094 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) DMO12_08097 ENOG4105D3G Pseudouridine synthase DMO12_08106 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DMO12_08124 ENOG4105JAB phenazine biosynthesis protein, phzf family DMO12_08127 ENOG4108ETY sodium dicarboxylate symporter DMO12_08130 ENOG4105EGI Transcriptional regulator DMO12_08133 ENOG4105CBP Major Facilitator DMO12_08145 ENOG4108R99 pseudouridine synthase DMO12_08148 ENOG4105E9K Isocitrate dehydrogenase DMO12_08154 ENOG4105DZ1 carboxypeptidase DMO12_08157 ENOG4105CEP NADH dehydrogenase DMO12_08160 ENOG4108YZY peptidylprolyl cis-trans isomerase DMO12_08163 ENOG4105CVP deoxyribo-dipyrimidine photolyase DMO12_08172 ENOG4107R8N Glycosyl transferase, family 2 DMO12_08190 ENOG4105EA8 2-Nitropropane dioxygenase DMO12_08193 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DMO12_08403 ENOG4107QS8 (LipO)protein DMO12_08424 ENOG4105DTR rard protein DMO12_08430 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DMO12_08436 ENOG4105BZU Histidine kinase DMO12_08457 ENOG4105EMU Dehydrogenase DMO12_08460 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase DMO12_08463 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) DMO12_08466 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) DMO12_08472 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DMO12_08481 ENOG4105C3F Signal peptidase i DMO12_08490 ENOG4105C0H protease DMO12_08493 ENOG4108IYU L-aspartate oxidase DMO12_08502 ENOG4105HHA aminodeoxychorismate lyase DMO12_08505 ENOG4105YAZ 4-amino-4-deoxychorismate lyase DMO12_08508 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DMO12_08514 ENOG4108I5D sulfate abc transporter DMO12_08520 ENOG4108IJ6 ABC transporter DMO12_08523 ENOG4107R11 Transcriptional regulator DMO12_08532 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DMO12_08535 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DMO12_08544 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DMO12_08553 ENOG4108UKI Enoyl-CoA hydratase DMO12_08556 ENOG4105EGD dinuclear metal center protein, YbgI family DMO12_08562 ENOG4105C2C drug resistance transporter, Bcr CflA DMO12_08565 ENOG4108ETH Formylglycinamide ribotide synthetase DMO12_08577 ENOG4105CH2 amidohydrolase DMO12_08580 ENOG4107YD3 Thioesterase DMO12_08583 ENOG4105E02 MotA TolQ exbB proton channel DMO12_08586 ENOG4105M8F Biopolymer transport protein exbD tolR DMO12_08592 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) DMO12_08595 ENOG4105KCK Peptidoglycan-associated lipoprotein DMO12_08625 ENOG4105C02 permease DMO12_08631 ENOG4108V3E phosphoribosylglycinamide formyltransferase DMO12_08634 ENOG4107R6F Alpha Beta Hydrolase Fold protein DMO12_08637 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) DMO12_08643 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DMO12_08646 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) DMO12_08649 ENOG4105D60 lipoprotein releasing system transmembrane protein DMO12_08670 ENOG4107KET secretion protein, HlyD family DMO12_08691 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DMO12_08694 ENOG4105C10 Electron transfer flavoprotein DMO12_08697 ENOG4105BZJ Electron transfer flavoprotein DMO12_08700 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DMO12_08703 ENOG4105N14 lysine exporter protein LysE YggA DMO12_08709 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DMO12_08715 ENOG4105C85 amino acid DMO12_08718 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DMO12_08724 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) DMO12_08733 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DMO12_08736 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit DMO12_08739 ENOG4105BZW Glycerate kinase DMO12_08763 ENOG4105CEY Amp-dependent synthetase and ligase DMO12_08772 ENOG4108RRZ Transcription elongation factor GreB DMO12_08784 ENOG4105E4C Lytic transglycosylase catalytic DMO12_08793 ENOG4105BZS acriflavin resistance protein DMO12_08796 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase DMO12_08802 ENOG41080IJ Diacylglycerol kinase DMO12_08814 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) DMO12_08823 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DMO12_08826 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DMO12_08829 ENOG4105CSH Transporter DMO12_08859 ENOG4105EEI dihydropteroate synthase DMO12_08862 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DMO12_08868 ENOG4105HBR Rna-binding protein DMO12_08877 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DMO12_08880 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DMO12_08889 ENOG41080TK Universal stress protein DMO12_08898 ENOG4105PNM synthesis protein DMO12_08907 ENOG4105EEQ Na H antiporter DMO12_08910 ENOG4105CGZ zinc metallopeptidase DMO12_08913 ENOG4105CKW Inner membrane protein yedI DMO12_08919 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DMO12_08925 ENOG4107QN2 dihydrolipoyl dehydrogenase DMO12_08928 ENOG4105C7S Dehydrogenase DMO12_08931 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 DMO12_08934 ENOG4105E33 succinate dehydrogenase DMO12_08940 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein DMO12_08943 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit DMO12_08958 ENOG4105F9F transposase DMO12_08970 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DMO12_08973 ENOG41084BA UPF0250 protein DMO12_08976 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) DMO12_08985 ENOG4105CUB amino acid DMO12_08991 ENOG4105KVH Transcriptional regulator DMO12_08994 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DMO12_08997 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DMO12_09006 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) DMO12_09021 ENOG410841Q phosphoesterase PA-phosphatase related protein DMO12_09024 ENOG4105C1P efflux transporter, rnd family, mfp subunit DMO12_09027 ENOG4105BZS acriflavin resistance protein DMO12_09030 ENOG4105ENJ RND efflux system, outer membrane lipoprotein DMO12_09033 ENOG4105K8R UPF0145 protein DMO12_09036 ENOG4105K8R UPF0145 protein DMO12_09048 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DMO12_09060 ENOG4108M0I Transcriptional regulator DMO12_09069 ENOG4105DHQ Histidine kinase DMO12_09072 ENOG4105XJC Two component transcriptional regulator (Winged helix family DMO12_09075 ENOG4105DIJ Phosphoethanolamine transferase DMO12_09087 ENOG4105D78 K07001 NTE family protein DMO12_09096 ENOG4105MSB protein, conserved in bacteria DMO12_09099 ENOG4105CTB Polyprenyl synthetase DMO12_09102 ENOG4105C7F AcnD-accessory protein PrpF DMO12_09105 ENOG4105C85 amino acid DMO12_09117 ENOG4105CF7 AraC family transcriptional regulator DMO12_09132 ENOG4108X0B nad(p)h dehydrogenase (quinone) DMO12_09138 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein DMO12_09144 ENOG4105D8T Acyltransferase DMO12_09150 ENOG4105C03 ribonuclease DMO12_09153 ENOG4108Z03 MAF-like protein DMO12_09156 ENOG4105VQ7 Rod shape-determining protein MreD DMO12_09159 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) DMO12_09162 ENOG4105DFF Rod shape-determining protein mreb DMO12_09165 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DMO12_09171 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DMO12_09192 ENOG4105C7B Threonine dehydratase DMO12_09195 ENOG4105D78 K07001 NTE family protein DMO12_09198 ENOG4105BZG amino acid carrier protein DMO12_09207 ENOG4105C2C drug resistance transporter, Bcr CflA DMO12_09210 ENOG4105EM2 membrane DMO12_09216 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DMO12_09240 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein DMO12_09243 ENOG4105WD1 Membrane DMO12_09249 ENOG4106HKS Entericidin EcnA/B family DMO12_09258 ENOG4105CBS Chea signal transduction histidine kinase DMO12_09261 ENOG4105C8Q Methyl-accepting chemotaxis DMO12_09264 ENOG4108ZGA chew protein DMO12_09267 ENOG4105M3Z response regulator DMO12_09270 ENOG4108UNF response regulator DMO12_09285 ENOG4105KWI UPF0339 protein DMO12_09288 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA DMO12_09291 ENOG4105K78 MarR family Transcriptional regulator DMO12_09297 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) DMO12_09300 ENOG4105T95 Thiol disulfide interChange protein DMO12_09306 ENOG4108N2Y auxin Efflux DMO12_09309 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DMO12_09312 ENOG4105CHB tonB-dependent Receptor DMO12_09315 ENOG4108VX5 3-methyladenine DNA glycosylase DMO12_09321 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DMO12_09333 ENOG4105C2W permease DMO12_09339 ENOG4108IQI permease DMO12_09342 ENOG4105E0Y RtcB Protein DMO12_09348 ENOG4108WHA ompa motb domain protein DMO12_09354 ENOG4105CHU acetyl-coa acetyltransferase DMO12_09366 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DMO12_09369 ENOG4105DZG Dehydrogenase DMO12_09372 ENOG4105TW1 Carbohydrate-selective porin OprB DMO12_09378 ENOG4108R6W Transcriptional regulator, ARAC family DMO12_09381 ENOG4105CHU acetyl-coa acetyltransferase DMO12_09402 ENOG4108UT2 hemolysin iii DMO12_09405 ENOG4105CSH Transporter DMO12_09414 ENOG4105D3R alkyl hydroperoxide reductase DMO12_09426 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DMO12_09447 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DMO12_09456 ENOG4108WBT adenosyltransferase DMO12_09468 ENOG4105CNG UPF0061 protein DMO12_09471 ENOG4105E3W Two component transcriptional regulator (Winged helix family DMO12_09474 ENOG4105EB3 Histidine kinase DMO12_09480 ENOG4105CSU acyl-Coa dehydrogenase DMO12_09483 ENOG4105CSU acyl-Coa dehydrogenase DMO12_09486 ENOG4108R4R Iron-regulated virulence regulatory protein DMO12_09489 ENOG4108K3A Glutathione S-transferase DMO12_09492 ENOG4108VY7 phosphate-starvation-inducible protein PsiE DMO12_09504 ENOG4105UGU tonB-dependent Receptor DMO12_09528 ENOG4108PQP glycosyl transferase group 1 DMO12_09534 ENOG4107BJW polysaccharide deacetylase DMO12_09543 ENOG4105CM2 brancheD-chain amino acid aminotransferase DMO12_09546 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) DMO12_09549 ENOG4105BZU Histidine kinase DMO12_09576 ENOG4105VIE preprotein translocase, subunit YajC DMO12_09579 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DMO12_09582 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DMO12_09585 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DMO12_09591 ENOG4105FFC UPF0187 protein DMO12_09594 ENOG4105DB7 PHP domain protein DMO12_09600 ENOG4105K9H YciI-like protein DMO12_09618 ENOG4105NAU thioesterase Superfamily protein DMO12_09624 ENOG4107U2T alpha beta DMO12_09627 ENOG4107QPB Beta-lactamase domain protein DMO12_09633 ENOG4107QN2 dihydrolipoyl dehydrogenase DMO12_09654 ENOG4108KHX Diguanylate cyclase DMO12_09657 ENOG4105UYK outer membrane protein a DMO12_09663 ENOG4107RZC phospholipase d DMO12_09669 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DMO12_09681 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) DMO12_09684 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DMO12_09687 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) DMO12_09693 ENOG4108UJD 30S ribosomal protein S9 DMO12_09696 ENOG4107MKT Stringent starvation protein a DMO12_09699 ENOG4105KB2 stringent starvation protein b DMO12_09711 ENOG4105F9F transposase DMO12_09717 ENOG4105C1G acyl-Coa dehydrogenase DMO12_09720 ENOG4107QX3 carboxylase DMO12_09729 ENOG4108RZE Tetr family transcriptional regulator DMO12_09732 ENOG4105C1G acyl-Coa dehydrogenase DMO12_09759 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DMO12_09762 ENOG4105D6S protein involved in catabolism of external DNA DMO12_09780 ENOG4105E4C Lytic transglycosylase catalytic DMO12_09786 ENOG4105C9A Phoh family DMO12_09804 ENOG4105CS1 NAD(P)H quinone oxidoreductase DMO12_09807 ENOG4107S2Z UPF0761 membrane protein DMO12_09813 ENOG4108K2B transcriptional regulator DMO12_09816 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase DMO12_09843 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DMO12_09846 ENOG4105DGW oligopeptidase A DMO12_09849 ENOG4105VKU nucleicacid-binding protein DMO12_09873 ENOG4105C1G acyl-Coa dehydrogenase DMO12_09888 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DMO12_09894 ENOG41067V7 50S ribosomal protein L36 DMO12_09897 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DMO12_09963 ENOG41089BK Glutamine amido-transferase DMO12_09966 ENOG4105C28 cystathionine DMO12_09969 ENOG4105D7A ATP-binding protein DMO12_09975 ENOG4105KPV Transcriptional regulator DMO12_09984 ENOG4105CK2 sodium dicarboxylate symporter DMO12_09987 ENOG4105C29 acyl-CoA thioesterase DMO12_09999 ENOG4105CB5 ATP-dependent DNA helicase recG DMO12_10002 ENOG4105MJ2 Competence protein DMO12_10008 ENOG4108URH decarboxylase DMO12_10011 ENOG4105D7N magnesium and cobalt transport protein CorA DMO12_10017 ENOG4105E3I toluene tolerance DMO12_10023 ENOG4105CY3 ABC transporter, permease DMO12_10026 ENOG4105DHJ ABC, transporter DMO12_10029 ENOG4105C1J atp-dependent rna helicase DMO12_10032 ENOG4105ECY inositol monophosphatase DMO12_10041 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) DMO12_10050 ENOG4105CSU acyl-Coa dehydrogenase DMO12_10056 ENOG41067S9 phage shock protein C, PspC DMO12_10059 ENOG4105W87 Cbs domain DMO12_10095 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DMO12_10110 ENOG4105C26 Dehydrogenase DMO12_10116 ENOG4105C8Y Acetylornithine aminotransferase DMO12_10119 ENOG4105D82 Glutamate dehydrogenase DMO12_10122 ENOG4108IQI permease DMO12_10143 ENOG4105IPI Membrane DMO12_10146 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DMO12_10149 ENOG4105EM2 membrane DMO12_10152 ENOG4107QF7 multi-drug DMO12_10158 ENOG4105NF4 modulator of drug activity DMO12_10161 ENOG4105VRH Antibiotic biosynthesis monooxygenase DMO12_10167 ENOG4105CQB FAD linked oxidase domain protein DMO12_10170 ENOG4108JQ1 Dehydrogenase DMO12_10185 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DMO12_10188 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) DMO12_10191 ENOG4107IFA Lipase (EC 3.1.1.3) DMO12_10200 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DMO12_10230 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DMO12_10236 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DMO12_10239 ENOG4105KME endoribonuclease L-psp DMO12_10245 ENOG4108UQY Iron-storage protein DMO12_10248 ENOG4108YSG O-Antigen polymerase DMO12_10254 ENOG4105X0D Fimbrial protein DMO12_10260 ENOG4105HA9 of methanol dehydrogenase type DMO12_10263 ENOG4108V0P LemA family DMO12_10269 ENOG4105BZ8 glutamate synthase DMO12_10272 ENOG4105CBC glutamate synthase DMO12_10284 ENOG4105E4G Type IV pilus DMO12_10299 ENOG4108JQC penicillin-binding protein 1A DMO12_10302 ENOG4105DHI Methyltransferase DMO12_10311 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) DMO12_10314 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DMO12_10317 ENOG4105CJN penicillin-binding protein DMO12_10326 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein DMO12_10341 ENOG4108IQI permease DMO12_10380 ENOG4105C5H ABC transporter DMO12_10386 ENOG4105PDP Short chain dehydrogenase DMO12_10389 ENOG4105CHH sulfate transporter DMO12_10395 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DMO12_10398 ENOG4105E0F Histidine kinase DMO12_10401 ENOG4105CYC Transferase DMO12_10419 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DMO12_10443 ENOG4105CUV Homoserine Kinase DMO12_10476 ENOG4108UQN AraC family transcriptional regulator DMO12_10479 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain DMO12_10488 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DMO12_10491 ENOG4105KVH Transcriptional regulator DMO12_10503 ENOG4105KVH Transcriptional regulator DMO12_10512 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) DMO12_10515 ENOG4105CPC Aldo Keto reductase DMO12_10530 ENOG4106NZI LysR family Transcriptional regulator DMO12_10533 ENOG4105D94 Major Facilitator Superfamily DMO12_10551 ENOG4105EUB pirin domain protein DMO12_10554 ENOG4105CHJ isochorismatase hydrolase DMO12_10560 ENOG4105C26 Dehydrogenase DMO12_10563 ENOG4108JPW Aminotransferase DMO12_10569 ENOG4105C85 amino acid DMO12_10575 ENOG4108UMN azlc family DMO12_10581 ENOG4108UUM single-stranded DNA-binding protein DMO12_10584 ENOG4107RDB Major Facilitator DMO12_10590 ENOG4105DWF phosphomethylpyrimidine kinase DMO12_10593 ENOG4105RA2 Membrane DMO12_10599 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein DMO12_10602 ENOG4108WUH Transcriptional regulator, TetR family DMO12_10605 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DMO12_10608 ENOG4105BZU Histidine kinase DMO12_10614 ENOG4105C94 Transporter DMO12_10620 ENOG4107QN1 sodium solute DMO12_10623 ENOG41062QD Membrane DMO12_10626 ENOG4105BZU Histidine kinase DMO12_10635 ENOG4108UZX fmn reductase DMO12_10638 ENOG4105FBW Monooxygenase DMO12_10644 ENOG4108W2Y isochorismatase DMO12_10647 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DMO12_10653 ENOG4105D64 Mechanosensitive ion channel DMO12_10659 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase DMO12_10662 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DMO12_10671 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) DMO12_10677 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DMO12_10686 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DMO12_10695 ENOG4105E0K tonB-dependent siderophore receptor DMO12_10704 ENOG4107QSN dihydrolipoamide acetyltransferase DMO12_10707 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) DMO12_10710 ENOG41063SB peptidase DMO12_10719 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DMO12_10722 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DMO12_10725 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) DMO12_10737 ENOG4105D7Z glutathione synthase DMO12_10749 ENOG4105CGK Exodeoxyribonuclease III DMO12_10752 ENOG4105KUZ arsenate reductase DMO12_10764 ENOG4105BZU Histidine kinase DMO12_10767 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) DMO12_10794 ENOG41061H0 Monooxygenase DMO12_10800 ENOG4108Z2U ureidoglycolate hydrolase DMO12_10803 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DMO12_10806 ENOG4105IPS esterase DMO12_10821 ENOG4105NVB glycoside hydrolase, family 19 DMO12_10824 ENOG4105CS6 Rhs element vgr protein DMO12_10830 ENOG4105D9M gamma-glutamylcysteine synthetase DMO12_10839 ENOG4106BRA Membrane DMO12_10842 ENOG4105CHM Aminotransferase DMO12_10845 ENOG4107QJQ Mate efflux family protein DMO12_10854 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DMO12_10857 ENOG4105BZU Histidine kinase DMO12_10866 ENOG4107SCA Formamidase (EC 3.5.1.49) DMO12_10872 ENOG4105KHC sulfurtransferase DMO12_10899 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DMO12_10908 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DMO12_10911 ENOG4108ZAI phosphatidylglycerophosphatase a DMO12_10917 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DMO12_10920 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DMO12_10923 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 DMO12_10929 ENOG41088SP formiminoglutamate hydrolase DMO12_10935 ENOG4105C85 amino acid DMO12_10944 ENOG41090B9 response to stress DMO12_10947 ENOG4105CZE histidine utilization repressor DMO12_10953 ENOG4105CKI cobalamin synthesis protein DMO12_10959 ENOG4105C85 amino acid DMO12_10965 ENOG4108RXX maleylacetoacetate isomerase DMO12_10977 ENOG4105EWC Purine nucleoside phosphorylase DMO12_10980 ENOG4107QI1 Mate efflux family protein DMO12_10983 ENOG4105C09 Bile acid DMO12_10986 ENOG4108RWI nicotinamidase DMO12_10989 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DMO12_11001 ENOG4105S64 Formate nitrite transporter DMO12_11004 ENOG4105D1H recombination factor protein RarA DMO12_11010 ENOG4108ZZ3 UPF0260 protein DMO12_11022 ENOG4105CEN a g-specific adenine glycosylase DMO12_11031 ENOG4108R3E Dna-3-methyladenine glycosylase i DMO12_11034 ENOG4105DQ4 alcohol dehydrogenase DMO12_11043 ENOG4105HEI LysR family (Transcriptional regulator DMO12_11046 ENOG4105CV8 reductase DMO12_11049 ENOG4105F27 Major Facilitator DMO12_11070 ENOG4105DJY efflux transporter, rnd family, mfp subunit DMO12_11073 ENOG4108IG5 Transcriptional regulator DMO12_11079 ENOG4105C2W permease DMO12_11097 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DMO12_11103 ENOG4105C8J )-transporter DMO12_20018 ENOG4105DZR Type I site-specific deoxyribonuclease DMO12_20024 ENOG4107SKI cobyrinic Acid a,c-diamide synthase DMO12_20036 ENOG4105K4U addiction module toxin, RelE StbE family DMO12_20060 ENOG4108HWY Beta-lactamase DMO12_30036 ENOG4105KK6 nuclease DMO12_30039 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS DMO12_30075 ENOG4105FA0 parb-like partition protein DMO12_30087 ENOG4105CDW Resistance protein DMO12_30141 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) DMO12_30189 ENOG4105F9F transposase DMO12_30195 ENOG4105F9F transposase DMO12_30213 ENOG4105K5T PilT protein DMO12_30231 ENOG4105T95 Thiol disulfide interChange protein DMO12_30279 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)