locus-tag class description E5D09_00010 ENOG41061TZ Short-chain dehydrogenase reductase Sdr E5D09_00015 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr E5D09_00025 ENOG4105CSU acyl-Coa dehydrogenase E5D09_00040 ENOG4105CEY Amp-dependent synthetase and ligase E5D09_00100 ENOG4105FDP GntR family transcriptional regulator E5D09_00115 ENOG4106KR7 LysR family Transcriptional regulator E5D09_00140 ENOG4105CW7 secretion protein, HlyD family E5D09_00180 ENOG4105CJP fad dependent oxidoreductase E5D09_00200 ENOG4105CJP fad dependent oxidoreductase E5D09_00235 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) E5D09_00240 ENOG4105C2C drug resistance transporter, Bcr CflA E5D09_00250 ENOG4105ERH Fumarylacetoacetate hydrolase E5D09_00260 ENOG4105C26 Dehydrogenase E5D09_00265 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase E5D09_00280 ENOG4105CNV Aldolase E5D09_00285 ENOG4105C26 Dehydrogenase E5D09_00290 ENOG4105CSH Transporter E5D09_00305 ENOG4108V8F Transcriptional regulator, MarR family E5D09_00310 ENOG4105CZJ Aldehyde dehydrogenase E5D09_00315 ENOG4105C01 Dihydroxy-acid dehydratase E5D09_00325 ENOG4105DDW LysR family Transcriptional regulator E5D09_00330 ENOG4105EXW epimerase dehydratase E5D09_00340 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5D09_00345 ENOG4105CF7 AraC family transcriptional regulator E5D09_00350 ENOG4105DQ4 alcohol dehydrogenase E5D09_00360 ENOG4105EHG Permease protein E5D09_00365 ENOG4105E0A ABC, transporter E5D09_00385 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E5D09_00485 ENOG4108BAS reductase E5D09_00490 ENOG41076PI Short-chain dehydrogenase reductase Sdr E5D09_00500 ENOG4108R6W Transcriptional regulator, ARAC family E5D09_00505 ENOG4108821 RND type efflux pump E5D09_00510 ENOG4105E0F Histidine kinase E5D09_00515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5D09_00520 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5D09_00525 ENOG4105BZS acriflavin resistance protein E5D09_00590 ENOG4105X0I Fimbrial E5D09_00640 ENOG4107RZC phospholipase d E5D09_00670 ENOG4108IGT Dipeptidase E5D09_00705 ENOG4107T31 5'-nucleotidase E5D09_00715 ENOG4105WQI isochorismatase E5D09_00720 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase E5D09_00725 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) E5D09_00730 ENOG4105E0C molybdate abc transporter E5D09_00735 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E5D09_00740 ENOG4105F4R Transcriptional regulator mode E5D09_00745 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit E5D09_00750 ENOG4108YS2 small subunit E5D09_00755 ENOG4105F57 Anthranilate dioxygenase reductase E5D09_00780 ENOG4105CHR reductase E5D09_00790 ENOG4105D2S major facilitator superfamily E5D09_00795 ENOG4105CF7 AraC family transcriptional regulator E5D09_00800 ENOG4105DTD Dehydrogenase E5D09_00805 ENOG4105CY2 Citrate transporter E5D09_00810 ENOG4105C5X domain protein E5D09_00845 ENOG4108M0I Transcriptional regulator E5D09_00860 ENOG4105CRW Short chain fatty acid transporter E5D09_00865 ENOG4105CHU acetyl-coa acetyltransferase E5D09_00875 ENOG4107YNJ LysR family Transcriptional regulator E5D09_00890 ENOG4108IJ0 Aspartate ammonia-lyase E5D09_00900 ENOG4105CSH Transporter E5D09_00920 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E5D09_00925 ENOG4106FTQ Taurine ABC transporter, periplasmic E5D09_00940 ENOG4105FDP GntR family transcriptional regulator E5D09_00950 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) E5D09_00955 ENOG4105KVH Transcriptional regulator E5D09_00960 ENOG4105UEI Transcriptional Regulator AraC Family E5D09_00975 ENOG4108VCT Sulfite exporter TauE/SafE E5D09_00995 ENOG4105FFC UPF0187 protein E5D09_01005 ENOG4105CHR reductase E5D09_01020 ENOG4105CPP Dehydrogenase, E1 component E5D09_01025 ENOG4107R0V Pyruvate dehydrogenase E5D09_01030 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E5D09_01055 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) E5D09_01060 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) E5D09_01105 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) E5D09_01120 ENOG4105C28 cystathionine E5D09_01130 ENOG4105F2W methyltransferase E5D09_01160 ENOG4105K59 histidine triad (HIT) protein E5D09_01185 ENOG4107QWP ABC-2 type transporter E5D09_01190 ENOG4107QWP ABC-2 type transporter E5D09_01195 ENOG4105CJ1 ABC, transporter E5D09_01210 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E5D09_01215 ENOG4105CNM Receptor E5D09_01235 ENOG4107TSN permease E5D09_01240 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5D09_01255 ENOG4107TB6 phosphoglycerate mutase E5D09_01260 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) E5D09_01265 ENOG4108YZT Adenosylcobinamide kinase E5D09_01305 ENOG4105JSC dimethylmenaquinone methyltransferase E5D09_01315 ENOG4105DJU Siderophore biosynthesis protein E5D09_01320 ENOG4105DUU IucA IucC family protein E5D09_01325 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5D09_01340 ENOG4108Z66 YbaK ebsC protein E5D09_01355 ENOG4105C1G acyl-Coa dehydrogenase E5D09_01360 ENOG4105C1G acyl-Coa dehydrogenase E5D09_01365 ENOG4105EEF Alkane 1-monooxygenase E5D09_01370 ENOG4105E7U AraC family transcriptional regulator E5D09_01375 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) E5D09_01380 ENOG4105K70 DNA-binding protein E5D09_01395 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family E5D09_01405 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E5D09_01410 ENOG4108Z4V iron-sulfur cluster assembly E5D09_01425 ENOG4108ZIT Ferredoxin, 2FE-2S E5D09_01430 ENOG4105F8J Adenylate Guanylate cyclase E5D09_01440 ENOG4108JA2 transcriptioN-repair coupling factor E5D09_01460 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) E5D09_01465 ENOG4105K4T epimerase E5D09_01480 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E5D09_01500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component E5D09_01510 ENOG4105DGW oligopeptidase A E5D09_01545 ENOG4105SG9 biopolymer transport protein, ExbD E5D09_01555 ENOG4107QP3 malate synthase g E5D09_01560 ENOG4105D6Z AFG1 family ATPase E5D09_01570 ENOG4107RN6 Monooxygenase E5D09_01600 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E5D09_01605 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E5D09_01620 ENOG4108Z6B deaminase E5D09_01640 ENOG4108RTD type II secretion system protein K E5D09_01665 ENOG4105F8V Hydrolase, tatD family E5D09_01675 ENOG4107QRG dna polymerase iii E5D09_01685 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) E5D09_01690 ENOG4105BZ1 (ABC) transporter E5D09_01705 ENOG4105FA0 parb-like partition protein E5D09_01710 ENOG4107QJE Chromosome Partitioning Protein E5D09_01720 ENOG4108S0S Nucleotidyl transferase E5D09_01725 ENOG4105EHM Aminoglycoside phosphotransferase E5D09_01730 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E5D09_01735 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) E5D09_01740 ENOG4105D2N Aldolase E5D09_01760 ENOG4108UHJ MAF-like protein E5D09_01765 ENOG4105EZE Cupin 4 family protein E5D09_01775 ENOG41080HT Transcriptional regulator, arsr family E5D09_01785 ENOG4105XPP Protein of unknown function (DUF1275) E5D09_01790 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E5D09_01795 ENOG4105BZ1 (ABC) transporter E5D09_01805 ENOG4108ZX5 transcriptional regulator E5D09_01815 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E5D09_01820 ENOG4105CK7 Sodium proline symporter E5D09_01825 ENOG4105EW9 transcriptional regulator AsnC family E5D09_01830 ENOG4105C26 Dehydrogenase E5D09_01835 ENOG4105YGK Pfam:UPF0157 E5D09_01850 ENOG4108T58 Mg2 transport protein CorA E5D09_01860 ENOG4108YYC ycei family E5D09_01870 ENOG4105CV1 Transketolase (EC 2.2.1.1) E5D09_01900 ENOG4108HWY Beta-lactamase E5D09_01920 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E5D09_01925 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E5D09_01945 ENOG4105X0I Fimbrial E5D09_01950 ENOG4105GQR Chaperone E5D09_01980 ENOG4108IPJ Membrane E5D09_01990 ENOG4105ETS cytosine purines uracil thiamine allantoin E5D09_02000 ENOG4105CC0 LysR family Transcriptional regulator E5D09_02020 ENOG41067SE Tetr family transcriptional regulator E5D09_02035 ENOG4105EW9 transcriptional regulator AsnC family E5D09_02045 ENOG4105CDA abc transporter atp-binding protein E5D09_02050 ENOG4105DRP amino acid AbC transporter E5D09_02055 ENOG4105EAD ABC transporter E5D09_02095 ENOG4105D01 (LipO)protein E5D09_02100 ENOG4105D01 (LipO)protein E5D09_02105 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E5D09_02110 ENOG4108UMI ABC transporter, permease E5D09_02115 ENOG4105C3G gtp-binding protein E5D09_02140 ENOG4108UMN azlc family E5D09_02145 ENOG4105ZED uncharacterized protein ygaH E5D09_02180 ENOG4108V06 Glutathione peroxidase E5D09_02190 ENOG4105CHM Aminotransferase E5D09_02205 ENOG4105C0B DNA polymerase III (alpha subunit) E5D09_02230 ENOG4108JU3 Alkyl hydroperoxide reductase E5D09_02245 ENOG4108KB2 LysR family Transcriptional regulator E5D09_02250 ENOG4105D6J arsenicaL-resistance protein E5D09_02255 ENOG41082YX Transcriptional regulator, arsr family E5D09_02270 ENOG4105CPN adenine deaminase E5D09_02280 ENOG4105CBN LysR family transcriptional regulator E5D09_02290 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease E5D09_02300 ENOG4105E2B Taurine dioxygenase E5D09_02305 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component E5D09_02310 ENOG4108IY8 ABC, transporter E5D09_02315 ENOG4106FTQ Taurine ABC transporter, periplasmic E5D09_02325 ENOG4105C54 Major Facilitator superfamily E5D09_02350 ENOG4105C4M (Ubiquinol oxidase) subunit I E5D09_02355 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5D09_02365 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E5D09_02370 ENOG4108K70 Transcriptional regulator E5D09_02390 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase E5D09_02405 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) E5D09_02410 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E5D09_02420 ENOG4105ETT transcriptional Regulator, LysR family E5D09_02430 ENOG4105DXI Major Facilitator superfamily E5D09_02450 ENOG41067MG lrgb family E5D09_02455 ENOG4105VAW lrga family E5D09_02460 ENOG4105CMU LysR family (Transcriptional regulator E5D09_02465 ENOG4108SHQ Glutathione S-transferase E5D09_02470 ENOG4105CYM Glutathione S-transferase E5D09_02475 ENOG4105CBN LysR family transcriptional regulator E5D09_02480 ENOG4105CHR reductase E5D09_02490 ENOG4105D7W serine acetyltransferase E5D09_02495 ENOG4105ESN nucleotide-binding protein E5D09_02500 ENOG4105C9B Cysteine desulfurase E5D09_02510 ENOG4105EXG Transcriptional regulator E5D09_02520 ENOG4105CT1 (ABC) transporter E5D09_02525 ENOG4107RP9 extracellular solute-binding protein, family 3 E5D09_02535 ENOG4108HW4 amino acid AbC transporter E5D09_02540 ENOG4105EAD ABC transporter E5D09_02555 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase E5D09_02560 ENOG4105BZU Histidine kinase E5D09_02570 ENOG4105EW9 transcriptional regulator AsnC family E5D09_02580 ENOG4105KT5 UmuD protein E5D09_02600 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E5D09_02645 ENOG4105HEI LysR family (Transcriptional regulator E5D09_02665 ENOG4105CEY Amp-dependent synthetase and ligase E5D09_02670 ENOG4105R8C Transcriptional regulator E5D09_02675 ENOG4105C1G acyl-Coa dehydrogenase E5D09_02680 ENOG4107QX3 carboxylase E5D09_02685 ENOG4105E39 Enoyl-CoA hydratase E5D09_02700 ENOG4105CC0 LysR family Transcriptional regulator E5D09_02715 ENOG4105CSU acyl-Coa dehydrogenase E5D09_02725 ENOG4105EQ0 Major Facilitator superfamily E5D09_02735 ENOG4107QNJ CoA-transferase subunit B E5D09_02740 ENOG4107QP7 CoA-transferase subunit A E5D09_02745 ENOG4107RGD Major Facilitator superfamily E5D09_02790 ENOG4105VUH addiction module killer protein E5D09_02795 ENOG4105YES addiction module antidote protein E5D09_02875 ENOG4105CNA YD repeat protein E5D09_02895 ENOG4105U0R haloacid dehalogenase-like hydrolase E5D09_02915 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) E5D09_02935 ENOG4105D2S major facilitator superfamily E5D09_02955 ENOG4107QUT magnesium and cobalt transport protein CorA E5D09_02960 ENOG4105D1S lipid A biosynthesis E5D09_02965 ENOG4105BZU Histidine kinase E5D09_02970 ENOG4107AQZ Membrane E5D09_02990 ENOG4108Z4U Ferredoxin E5D09_03035 ENOG4108IUZ ABC transporter E5D09_03040 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E5D09_03050 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase E5D09_03055 ENOG4105C2X Arabinose 5-phosphate isomerase E5D09_03095 ENOG4107YPT transcriptional regulator E5D09_03130 ENOG4105II7 pyrroline-5-carboxylate reductase E5D09_03145 ENOG4105VEQ Cold shock protein E5D09_03150 ENOG410829K Lysine exporter protein (Lyse ygga) E5D09_03180 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E5D09_03245 ENOG4105EUV Phenol 2-monooxygenase E5D09_03265 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein E5D09_03275 ENOG4108KB2 LysR family Transcriptional regulator E5D09_03280 ENOG4105FUY alpha subunit E5D09_03285 ENOG4108UKV benzoate 1,2-dioxygenase E5D09_03290 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein E5D09_03295 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase E5D09_03300 ENOG4105DKK Benzoate E5D09_03305 ENOG4105D2S major facilitator superfamily E5D09_03320 ENOG4105CQ7 ATP-dependent helicase E5D09_03325 ENOG4105D3R alkyl hydroperoxide reductase E5D09_03335 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) E5D09_03345 ENOG4108JU3 Alkyl hydroperoxide reductase E5D09_03360 ENOG4108K3A Glutathione S-transferase E5D09_03370 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) E5D09_03375 ENOG4108TGY Glutathione S-transferase E5D09_03385 ENOG4108ZG0 Ompa motb domain protein E5D09_03390 ENOG4105CD3 dihydroorotase E5D09_03420 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5D09_03435 ENOG4108UKZ OsmC family E5D09_03440 ENOG4107RYR Transcriptional regulator, Crp Fnr family E5D09_03445 ENOG4105CPC Aldo Keto reductase E5D09_03460 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis E5D09_03475 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E5D09_03485 ENOG4105CFH Aspartokinase E5D09_03495 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) E5D09_03505 ENOG4105CPW cytochrome b561 E5D09_03510 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) E5D09_03515 ENOG4105C7N Xanthine uracil vitamin C permease E5D09_03525 ENOG4105F95 Monooxygenase E5D09_03560 ENOG4105F95 Monooxygenase E5D09_03565 ENOG4105JQZ Methyltransferase E5D09_03575 ENOG4107RN6 Monooxygenase E5D09_03595 ENOG4105EPF Outer membrane porin E5D09_03600 ENOG4105D2S major facilitator superfamily E5D09_03605 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E5D09_03610 ENOG4105E6M Sulphatase-modifying factor protein E5D09_03625 ENOG4105E3J oxidoreductase E5D09_03640 ENOG4108SC4 )-transporter E5D09_03645 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase E5D09_03660 ENOG4105C1G acyl-Coa dehydrogenase E5D09_03665 ENOG4105EPF Outer membrane porin E5D09_03670 ENOG4105NI3 Protein of unknown function (DUF3237) E5D09_03685 ENOG4105JXH GntR family transcriptional regulator E5D09_03690 ENOG4105CZJ Aldehyde dehydrogenase E5D09_03700 ENOG4105EQX glucarate dehydratase E5D09_03705 ENOG4105DJB Major Facilitator Superfamily E5D09_03710 ENOG4105CTX dehydratase E5D09_03715 ENOG4105DJP Membrane E5D09_03720 ENOG4108ZX5 transcriptional regulator E5D09_03725 ENOG4107RGH Aldehyde dehydrogenase E5D09_03750 ENOG4105C85 amino acid E5D09_03770 ENOG4105C26 Dehydrogenase E5D09_03790 ENOG4105CUB amino acid E5D09_03800 ENOG4105C85 amino acid E5D09_03840 ENOG4105CNA YD repeat protein E5D09_03855 ENOG4105D01 (LipO)protein E5D09_03860 ENOG4108M3P Membrane E5D09_03875 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5D09_03895 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) E5D09_03915 ENOG4108JQ5 ABC transporter E5D09_03920 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E5D09_03925 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E5D09_03935 ENOG4105E9H Lytic Murein transglycosylase E5D09_03935 ENOG4105E9H Lytic Murein transglycosylase E5D09_03940 ENOG4107RZZ dna polymerase iii epsilon subunit E5D09_03950 ENOG4105E09 nadh pyrophosphatase E5D09_03960 ENOG4105W4M Transport-associated protein E5D09_03970 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E5D09_03980 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) E5D09_03985 ENOG4108ZUB Lysine exporter protein (Lyse ygga) E5D09_04005 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E5D09_04010 ENOG4105D0A hydroxylase E5D09_04015 ENOG4107RAQ aminopeptidase E5D09_04135 ENOG4105E4C Lytic transglycosylase catalytic E5D09_04400 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E5D09_04420 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E5D09_04430 ENOG4105D82 Glutamate dehydrogenase E5D09_04435 ENOG4108R3D Electron transport complex E5D09_04440 ENOG4105CSM endonuclease III E5D09_04465 ENOG4105CJN penicillin-binding protein E5D09_04470 ENOG4106H78 methyltransferase E5D09_04485 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) E5D09_04495 ENOG4105CQM Urea amidohydrolase subunit alpha E5D09_04525 ENOG4107RET Isocitrate lyase E5D09_04535 ENOG4105C37 (CBS) domain E5D09_04545 ENOG4105D4T Citrate transporter E5D09_04560 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) E5D09_04575 ENOG4108MRJ E5D09_04595 ENOG4105VCQ rubredoxin E5D09_04600 ENOG4107QZF nitrite reductase NADPH large subunit E5D09_04610 ENOG4105C5Q Transcriptional regulator E5D09_04635 ENOG4107U91 Rhomboid family E5D09_04640 ENOG4105CV6 ABC transporter, permease E5D09_04645 ENOG4108I0Y (ABC) transporter E5D09_04650 ENOG4108UJV acyl-CoA thioesterase i E5D09_04670 ENOG4107RNH Outer membrane receptor FepA E5D09_04685 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E5D09_04690 ENOG4105E6M Sulphatase-modifying factor protein E5D09_04710 ENOG4105CJ3 phosphate transporter E5D09_04715 ENOG4105C3R Methionine synthase E5D09_04730 ENOG4105CSP Major Facilitator Superfamily E5D09_04740 ENOG4108PZW LysR family Transcriptional regulator E5D09_04755 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) E5D09_04760 ENOG4105EU0 Major facilitator Superfamily E5D09_04765 ENOG4108R6W Transcriptional regulator, ARAC family E5D09_04770 ENOG4105CSV Glutaminase E5D09_04775 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) E5D09_04780 ENOG4105CSH Transporter E5D09_04790 ENOG4105C7K acetolactate synthase E5D09_04795 ENOG4105C26 Dehydrogenase E5D09_04805 ENOG4105CHR reductase E5D09_04810 ENOG4108MXF Alpha Beta Hydrolase E5D09_04820 ENOG4105DJB Major Facilitator Superfamily E5D09_04835 ENOG4105CHR reductase E5D09_04855 ENOG41069M3 Transcriptional regulator E5D09_04870 ENOG4106YT9 Enoyl-CoA hydratase E5D09_04880 ENOG4105CND Glycosyl transferase, family 2 E5D09_04885 ENOG4107BJW polysaccharide deacetylase E5D09_04895 ENOG4108VWS Yaeq family E5D09_04905 ENOG4105CKI cobalamin synthesis protein E5D09_04925 ENOG4105C94 Transporter E5D09_04930 ENOG4105C94 Transporter E5D09_04935 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) E5D09_04960 ENOG4107QK5 Homocysteine s-methyltransferase E5D09_04965 ENOG4105D5Q Arginine ornithine antiporter E5D09_04990 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E5D09_04995 ENOG4105C54 Major Facilitator superfamily E5D09_05055 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) E5D09_05060 ENOG4105NI8 Cytosine-specific methyltransferase E5D09_05135 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E5D09_05140 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5D09_05145 ENOG4105CW7 secretion protein, HlyD family E5D09_05150 ENOG4108VUY thioesterase Superfamily protein E5D09_05155 ENOG4105D52 delta-aminolevulinic acid dehydratase E5D09_05160 ENOG4105MWK D-amino acid dehydrogenase, small subunit E5D09_05185 ENOG4107RH8 nuclease SbcCD subunit D E5D09_05190 ENOG4105EYH Exonuclease E5D09_05195 ENOG4105DFA alanine racemase domain protein E5D09_05200 ENOG4105CZX twitching motility protein E5D09_05205 ENOG4105CZX twitching motility protein E5D09_05210 ENOG41090R7 Ferric uptake E5D09_05240 ENOG4105E7A Glutamine amidotransferase E5D09_05255 ENOG4107QKV phosphomannomutase E5D09_05265 ENOG4105C4R Atp-dependent dna helicase E5D09_05270 ENOG4108ZG0 Ompa motb domain protein E5D09_05275 ENOG4106HNH Acyl-transferase E5D09_05290 ENOG4107QMS site-determining protein E5D09_05315 ENOG4105CNU cell division protein FtsK E5D09_05320 ENOG4105C3M thioredoxin reductase E5D09_05325 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) E5D09_05335 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E5D09_05385 ENOG4108YXA Membrane E5D09_05390 ENOG4105EUB pirin domain protein E5D09_05400 ENOG4105C4K Nad synthetase E5D09_05415 ENOG4105E3J oxidoreductase E5D09_05420 ENOG4105C26 Dehydrogenase E5D09_05425 ENOG4105DVW rieske (2Fe-2S) E5D09_05435 ENOG4105C94 Transporter E5D09_05440 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E5D09_05445 ENOG4105EJC lysr family transcriptional regulator E5D09_05465 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E5D09_05485 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E5D09_05490 ENOG4105C34 Pseudouridine synthase E5D09_05495 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E5D09_05500 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E5D09_05515 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) E5D09_05540 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E5D09_05570 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) E5D09_05580 ENOG4105DWF phosphomethylpyrimidine kinase E5D09_05585 ENOG4109066 lysm domain bon superfamily protein E5D09_05595 ENOG4105CHR reductase E5D09_05600 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E5D09_05610 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E5D09_05615 ENOG4108BPE -transporting atpase E5D09_05620 ENOG4107RTD sua5 ycio yrdc ywlc family protein E5D09_05625 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) E5D09_05630 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) E5D09_05635 ENOG4105FE9 pseudouridine synthase E5D09_05645 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E5D09_05650 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E5D09_05660 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E5D09_05665 ENOG4108K4C ec 3.1.3.12 E5D09_05670 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase E5D09_05675 ENOG4106UW1 Major Facilitator superfamily E5D09_05695 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) E5D09_05705 ENOG4105HF0 Membrane E5D09_05720 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E5D09_05730 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) E5D09_05790 ENOG4105D1F ATP-binding protein E5D09_05800 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) E5D09_05830 ENOG4105K6H D-cysteine desulfhydrase E5D09_05835 ENOG4105CBX hi0933 family E5D09_05860 ENOG4105DP0 ferredoxin-NADP reductase E5D09_05865 ENOG4105DUM transcriptional regulator, lysR family E5D09_05885 ENOG4105C8S subunit m E5D09_05890 ENOG4105D65 subunit l E5D09_05900 ENOG4107UFS subunit j E5D09_05915 ENOG4108IEH NADH dehydrogenase subunit g E5D09_05920 ENOG4107QIZ NADH dehydrogenase E5D09_05925 ENOG4105GKE subunit e E5D09_05945 ENOG4105BZU Histidine kinase E5D09_05955 ENOG4105E0F Histidine kinase E5D09_05960 ENOG4107EXC regulatoR E5D09_05970 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5D09_05980 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5D09_06025 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) E5D09_06030 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) E5D09_06040 ENOG4105ETT transcriptional Regulator, LysR family E5D09_06050 ENOG4106P55 Transcriptional regulator E5D09_06070 ENOG4106P55 Transcriptional regulator E5D09_06075 ENOG4107EFR Flavocytochrome c E5D09_06095 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F E5D09_06100 ENOG4107RGD Major Facilitator superfamily E5D09_06105 ENOG4105C1G acyl-Coa dehydrogenase E5D09_06110 ENOG4105ETT transcriptional Regulator, LysR family E5D09_06150 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) E5D09_06155 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) E5D09_06160 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E5D09_06180 ENOG4105E3B Multicopper oxidase E5D09_06190 ENOG4108HCJ Hydrolase E5D09_06195 ENOG4105DJV ribulose-phosphate 3-epimerase E5D09_06220 ENOG41072GX Peptidase M22 Glycoprotease E5D09_06225 ENOG4108Z0R Transferase E5D09_06275 ENOG4105CRQ synthase (Component I) E5D09_06285 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) E5D09_06290 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) E5D09_06295 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) E5D09_06365 ENOG4105K56 Transcriptional regulator E5D09_06370 ENOG4108ZHJ Organic hydroperoxide resistance protein E5D09_06375 ENOG4107QHF type ii secretion system protein e E5D09_06395 ENOG4105C2M dna polymerase I E5D09_06400 ENOG4108VIA integral membrane protein E5D09_06405 ENOG4105II7 pyrroline-5-carboxylate reductase E5D09_06410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E5D09_06420 ENOG4105C9X ppx gppa phosphatase E5D09_06430 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E5D09_06450 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E5D09_06475 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) E5D09_06490 ENOG4105W39 Membrane E5D09_06495 ENOG4105CYM Glutathione S-transferase E5D09_06515 ENOG4105CEY Amp-dependent synthetase and ligase E5D09_06520 ENOG4105N42 UPF0307 protein E5D09_06525 ENOG41080Z8 PHOSPHOCARRIER protein E5D09_06545 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E5D09_06550 ENOG4105DJ0 Poly(A) Polymerase E5D09_06555 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein E5D09_06560 ENOG4105DXN mazG family E5D09_06570 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E5D09_06585 ENOG4105C6T cysteine synthase E5D09_06590 ENOG4105BZU Histidine kinase E5D09_06595 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase E5D09_06600 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5D09_06605 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E5D09_06620 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E5D09_06625 ENOG4105W8H transhydrogenase (subunit alpha E5D09_06630 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E5D09_06635 ENOG4106UX7 integral membrane protein E5D09_06655 ENOG4105H3G oxidoreductase E5D09_06660 ENOG4105C3M thioredoxin reductase E5D09_06665 ENOG4105CAU Arsenical resistance protein, ArsH E5D09_06670 ENOG4105D6J arsenicaL-resistance protein E5D09_06680 ENOG4105KBH arsR family transcriptional regulator E5D09_06705 ENOG4105CE1 Ferrous iron transport protein b E5D09_06725 ENOG4105E3B Multicopper oxidase E5D09_06740 ENOG4105GR3 Histidine kinase E5D09_06825 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E5D09_06835 ENOG4107RSM transcriptional regulator E5D09_06845 ENOG4105CUZ uba thif-type nad fad binding protein E5D09_06850 ENOG4107QM5 aconitate hydratase E5D09_06855 ENOG4105F8V Hydrolase, tatD family E5D09_06870 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) E5D09_06895 ENOG4105BZU Histidine kinase E5D09_06905 ENOG4108ZP8 Acetolactate synthase small subunit E5D09_06910 ENOG4105C7K acetolactate synthase E5D09_06935 ENOG4105DJY efflux transporter, rnd family, mfp subunit E5D09_06940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E5D09_06945 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E5D09_06950 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E5D09_06960 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) E5D09_06965 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) E5D09_06975 ENOG4105VW4 glutaredoxin 3 E5D09_06995 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) E5D09_07015 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) E5D09_07035 ENOG4105WVQ Fe-S assembly protein IscX E5D09_07050 ENOG4105CN1 protease E5D09_07075 ENOG4105C26 Dehydrogenase E5D09_07080 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E5D09_07085 ENOG4105C6Z Gluconate E5D09_07090 ENOG4108UHU Aldolase E5D09_07095 ENOG4105C01 Dihydroxy-acid dehydratase E5D09_07100 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E5D09_07105 ENOG4108DNC Involved in acetate metabolism (By similarity) E5D09_07110 ENOG4107GFK fumarate E5D09_07130 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E5D09_07165 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) E5D09_07175 ENOG4105DWV Homoserine O-trans-acetylase E5D09_07275 ENOG4105CIY formyltetrahydrofolate deformylase E5D09_07285 ENOG4107RGH Aldehyde dehydrogenase E5D09_07290 ENOG4105KDC 50s ribosomal protein l28 E5D09_07295 ENOG4105W0E 50S ribosomal protein L33 E5D09_07300 ENOG4105CKD glutathione-regulated potassium-efflux system protein E5D09_07320 ENOG4105VFU Rna-binding protein E5D09_07325 ENOG4105C4R Atp-dependent dna helicase E5D09_07340 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E5D09_07350 ENOG4105KVH Transcriptional regulator E5D09_07360 ENOG41069P5 Protein slyX homolog E5D09_07365 ENOG4105C5H ABC transporter E5D09_07370 ENOG4105N14 lysine exporter protein LysE YggA E5D09_07375 ENOG4105D1S lipid A biosynthesis E5D09_07385 ENOG4105CK2 sodium dicarboxylate symporter E5D09_07410 ENOG4105HDK L-asparaginase E5D09_07440 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E5D09_07465 ENOG4105DUM transcriptional regulator, lysR family E5D09_07480 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E5D09_07495 ENOG4108W5M transcriptional regulator E5D09_07520 ENOG4105D29 Helix-turn-helix type 11 domain protein E5D09_07525 ENOG4107XGZ Hydrolase E5D09_07530 ENOG4105EI2 Pseudouridine synthase E5D09_07540 ENOG4105C03 ribonuclease E5D09_07560 ENOG4105CBN LysR family transcriptional regulator E5D09_07575 ENOG4105CSA Coproporphyrinogen iii oxidase E5D09_07585 ENOG4107QI1 Mate efflux family protein E5D09_07595 ENOG4107T8P acyl-Coa dehydrogenase E5D09_07630 ENOG4105BZ8 glutamate synthase E5D09_07640 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) E5D09_07645 ENOG4105C5X domain protein E5D09_07660 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) E5D09_07670 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E5D09_07680 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) E5D09_07685 ENOG4108JU5 Magnesium and cobalt efflux protein E5D09_07690 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) E5D09_07695 ENOG4108Z7R Chaperone CsaA E5D09_07705 ENOG4108VAU general secretion pathway protein G E5D09_07710 ENOG4105D7Q type ii secretion system E5D09_07715 ENOG4105C25 Primosomal protein n' E5D09_07720 ENOG4105CKD glutathione-regulated potassium-efflux system protein E5D09_07735 ENOG4105DVC DnaJ domain protein E5D09_07740 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) E5D09_07745 ENOG4107QUT magnesium and cobalt transport protein CorA E5D09_07765 ENOG4107QYX exodeoxyribonuclease v alpha E5D09_07770 ENOG4107QKA exodeoxyribonuclease V beta E5D09_07775 ENOG4105DSY exodeoxyribonuclease V, gamma E5D09_07785 ENOG4105CSR polyphosphate kinase 2 E5D09_07795 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) E5D09_07805 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) E5D09_07815 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase E5D09_07820 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase E5D09_07835 ENOG4105D65 subunit l E5D09_07840 ENOG4108ZE9 Monovalent cation H antiporter subunit C E5D09_07845 ENOG4107R4Z monovalent cation h antiporter subunit d E5D09_07850 ENOG4105SC1 monovalent cation H antiporter subunit E E5D09_07855 ENOG4105W4C monovalent cation H antiporter subunit F E5D09_07860 ENOG4105KJM monovalent cation h antiporter subunit g E5D09_07875 ENOG4105CHV Transcription elongation factor NusA E5D09_07900 ENOG4107EJC Preprotein translocase subunit SecG E5D09_07910 ENOG4107QHF type ii secretion system protein e E5D09_07925 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E5D09_07935 ENOG4105C2N RNA methyltransferase TrmH family group 3 E5D09_07950 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E5D09_07960 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) E5D09_07990 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E5D09_07995 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase E5D09_08055 ENOG4107ZXU DSBA oxidoreductase E5D09_08070 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) E5D09_08085 ENOG4105D3Y Na H antiporter E5D09_08140 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E5D09_08145 ENOG4105PM1 preprotein translocase subunit SecE E5D09_08185 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E5D09_08190 ENOG4105TV9 FHA Domain-Containing protein E5D09_08195 ENOG4105GVR general secretion pathway protein D E5D09_08210 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS E5D09_08235 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) E5D09_08240 ENOG4108NEV two component transcriptional regulator, LytTR family E5D09_08245 ENOG4108HRK Histidine kinase E5D09_08260 ENOG4108UTW Plays a role in the regulation of phosphate uptake E5D09_08270 ENOG4108RNG Permease of the drug metabolite transporter E5D09_08295 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E5D09_08300 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters E5D09_08305 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) E5D09_08310 ENOG4105CNI cell division protein FtsW E5D09_08325 ENOG4105CE1 Ferrous iron transport protein b E5D09_08335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5D09_08340 ENOG4105T95 Thiol disulfide interChange protein E5D09_08345 ENOG4105D6E homoserine dehydrogenase E5D09_08355 ENOG41061WM D-Alanyl-D-Alanine E5D09_08365 ENOG4107TUY Histidine kinase E5D09_08370 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5D09_08375 ENOG4105CN1 protease E5D09_08380 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) E5D09_08385 ENOG4108K5H permease YjgP YjgQ family protein E5D09_08425 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E5D09_08435 ENOG4105BZU Histidine kinase E5D09_08450 ENOG4105C0P Mg chelatase subunit ChlI E5D09_08460 ENOG4105CHH sulfate transporter E5D09_08505 ENOG4105C0P Mg chelatase subunit ChlI E5D09_08510 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E5D09_08520 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E5D09_08530 ENOG4105EPF Outer membrane porin E5D09_08535 ENOG4105F0N pyrophosphate phospho-hydrolase E5D09_08550 ENOG4105CEY Amp-dependent synthetase and ligase E5D09_08555 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5D09_08560 ENOG41079KZ Major Facilitator Superfamily E5D09_08565 ENOG4105EN6 Membrane E5D09_08575 ENOG4105EE5 Membrane protein terC E5D09_08580 ENOG4108URH decarboxylase E5D09_08585 ENOG4105C0R drug resistance transporter emrb qaca subfamily E5D09_08595 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E5D09_08610 ENOG4105CCT upf0313 protein E5D09_08630 ENOG4105CS1 NAD(P)H quinone oxidoreductase E5D09_08640 ENOG4105C6T cysteine synthase E5D09_08675 ENOG4105Y7M Transcriptional regulator, TetR family E5D09_08725 ENOG4105C79 DNA protecting protein DprA E5D09_08740 ENOG4108IND Tetr family transcriptional regulator E5D09_08745 ENOG4107RTG Major Facilitator superfamily E5D09_08755 ENOG4108V06 Glutathione peroxidase E5D09_08795 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) E5D09_08820 ENOG4105FDK ABC transporter E5D09_08825 ENOG4105FAV ABC, transporter E5D09_08835 ENOG4105EZR dyp-type peroxidase family protein E5D09_08840 ENOG4107R1I NAD-dependent malic enzyme E5D09_08865 ENOG4105EUB pirin domain protein E5D09_08880 ENOG4106JUT Streptomycin 3''-adenylyltransferase E5D09_08885 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E5D09_08890 ENOG4106MP8 UPF0754 membrane protein E5D09_08895 ENOG4108VBZ doxx family E5D09_08900 ENOG4105DQR SNARE associated Golgi E5D09_08915 ENOG4107QJE Chromosome Partitioning Protein E5D09_08925 ENOG4107PSF BolA-like protein E5D09_08970 ENOG4105C1G acyl-Coa dehydrogenase E5D09_08995 ENOG4105CSH Transporter E5D09_09000 ENOG4105E39 Enoyl-CoA hydratase E5D09_09005 ENOG4105E39 Enoyl-CoA hydratase E5D09_09010 ENOG4105C1G acyl-Coa dehydrogenase E5D09_09020 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E5D09_09025 ENOG4105C26 Dehydrogenase E5D09_09035 ENOG4105C85 amino acid E5D09_09040 ENOG4105C85 amino acid E5D09_09045 ENOG4105M4H endoribonuclease L-psp E5D09_09060 ENOG4105EW9 transcriptional regulator AsnC family E5D09_09085 ENOG4105D3G Pseudouridine synthase E5D09_09130 ENOG4108I0Z Aconitate hydratase E5D09_09135 ENOG4105BZN citrate synthase E5D09_09140 ENOG4105CR4 methylisocitrate lyase E5D09_09145 ENOG4105DRR Transcriptional regulator, GntR family E5D09_09155 ENOG4105CGF Aromatic amino acid aminotransferase E5D09_09160 ENOG4105CXG d-lactate dehydrogenase E5D09_09170 ENOG41073TP transcriptional regulator E5D09_09175 ENOG4105DAA L-lactate E5D09_09180 ENOG4107QKV phosphomannomutase E5D09_09185 ENOG4105CMR udp-glucose 4-epimerase E5D09_09195 ENOG4105C6Y Udp-glucose 6-dehydrogenase E5D09_09200 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E5D09_09205 ENOG4105D3Q Sugar transferase E5D09_09210 ENOG4105C6Y Udp-glucose 6-dehydrogenase E5D09_09220 ENOG4105CPK Glycosyl transferase (Group 1 E5D09_09230 ENOG4108RYC glycosyltransferase E5D09_09235 ENOG4108ZPC Polysaccharide pyruvyl transferase E5D09_09245 ENOG4107QQG Dehydrogenase E5D09_09250 ENOG4105DAY polysaccharide export protein E5D09_09260 ENOG4105D75 Capsular exopolysaccharide family E5D09_09265 ENOG4108V1T peptidylprolyl cis-trans isomerase E5D09_09270 ENOG4108V1T peptidylprolyl cis-trans isomerase E5D09_09275 ENOG4105CJR Integral membrane protein (MviN E5D09_09280 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E5D09_09285 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E5D09_09295 ENOG4105HSS phospholipase C E5D09_09320 ENOG41062JF Transcriptional regulator E5D09_09335 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E5D09_09340 ENOG4105UBK short-chain dehydrogenase reductase E5D09_09355 ENOG4107QZM n-acetylglutamate synthase E5D09_09360 ENOG4105GVF (ABC) transporter E5D09_09365 ENOG4105GVF (ABC) transporter E5D09_09370 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) E5D09_09375 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E5D09_09380 ENOG4108VM9 ABC, transporter E5D09_09385 ENOG4108R86 Transcriptional regulator E5D09_09390 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) E5D09_09400 ENOG4105DTN riboflavin biosynthesis protein ribF E5D09_09405 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) E5D09_09415 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E5D09_09455 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E5D09_09510 ENOG4105CVE Lytic murein transglycosylase E5D09_09515 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E5D09_09520 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E5D09_09535 ENOG4105DFU Cell wall formation (By similarity) E5D09_09545 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E5D09_09550 ENOG4105DU1 integral membrane protein, terc E5D09_09560 ENOG4106032 Glutathionylspermidine synthase E5D09_09570 ENOG4107QUY Guanine deaminase E5D09_09575 ENOG4108UGV hypoxanthine phosphoribosyltransferase E5D09_09585 ENOG4105T95 Thiol disulfide interChange protein E5D09_09590 ENOG4105PGM cation diffusion facilitator family transporter E5D09_09605 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins E5D09_09620 ENOG4105VG0 50S ribosomal protein l34 E5D09_09630 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E5D09_09640 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5D09_09650 ENOG4105DQR SNARE associated Golgi E5D09_09655 ENOG4105C5H ABC transporter E5D09_09660 ENOG4108821 RND type efflux pump E5D09_09665 ENOG4108821 RND type efflux pump E5D09_09670 ENOG4108821 RND type efflux pump E5D09_09685 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) E5D09_09690 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) E5D09_09735 ENOG4105C8J )-transporter E5D09_09745 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E5D09_09770 ENOG4108W5M transcriptional regulator E5D09_09775 ENOG4105C2W permease E5D09_09785 ENOG4108IG5 Transcriptional regulator E5D09_09790 ENOG4105DJY efflux transporter, rnd family, mfp subunit E5D09_09825 ENOG4105F27 Major Facilitator E5D09_09830 ENOG4105CV8 reductase E5D09_09835 ENOG4105HEI LysR family (Transcriptional regulator E5D09_09855 ENOG4105DQ4 alcohol dehydrogenase E5D09_09860 ENOG4108R3E Dna-3-methyladenine glycosylase i E5D09_09875 ENOG4105CEN a g-specific adenine glycosylase E5D09_09895 ENOG4108ZZ3 UPF0260 protein E5D09_09905 ENOG4105D1H recombination factor protein RarA E5D09_09910 ENOG4105S64 Formate nitrite transporter E5D09_09930 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E5D09_09935 ENOG4108RWI nicotinamidase E5D09_09940 ENOG4105C09 Bile acid E5D09_09945 ENOG4107QI1 Mate efflux family protein E5D09_09950 ENOG4105EWC Purine nucleoside phosphorylase E5D09_09970 ENOG4108RXX maleylacetoacetate isomerase E5D09_09980 ENOG4105C85 amino acid E5D09_09990 ENOG4105CKI cobalamin synthesis protein E5D09_10000 ENOG4105CZE histidine utilization repressor E5D09_10005 ENOG41090B9 response to stress E5D09_10020 ENOG4105C85 amino acid E5D09_10030 ENOG41088SP formiminoglutamate hydrolase E5D09_10045 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) E5D09_10065 ENOG4107SCJ type I restriction enzyme EcoKI subunit R E5D09_10070 ENOG41082EK Restriction modification system DNA (Specificity E5D09_10100 ENOG4105D70 Integrase catalytic subunit E5D09_10130 ENOG4105F9F transposase E5D09_10145 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase E5D09_10150 ENOG4105EPC oxidoreductase E5D09_10155 ENOG4105VF7 tolerance protein E5D09_10205 ENOG4105F9F transposase E5D09_10210 ENOG4105EUZ Beta-lactamase domain protein E5D09_10270 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E5D09_10280 ENOG4108ZAI phosphatidylglycerophosphatase a E5D09_10285 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E5D09_10300 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) E5D09_10340 ENOG4105KHC sulfurtransferase E5D09_10370 ENOG4105BZU Histidine kinase E5D09_10375 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5D09_10390 ENOG4107QJQ Mate efflux family protein E5D09_10395 ENOG4105CHM Aminotransferase E5D09_10400 ENOG4106BRA Membrane E5D09_10415 ENOG4105D9M gamma-glutamylcysteine synthetase E5D09_10425 ENOG4105CS6 Rhs element vgr protein E5D09_10430 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase E5D09_10460 ENOG4105IPS esterase E5D09_10465 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5D09_10470 ENOG4108Z2U ureidoglycolate hydrolase E5D09_10480 ENOG41061H0 Monooxygenase E5D09_10525 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E5D09_10530 ENOG4105BZU Histidine kinase E5D09_10545 ENOG4105KUZ arsenate reductase E5D09_10550 ENOG4105CGK Exodeoxyribonuclease III E5D09_10570 ENOG4105D7Z glutathione synthase E5D09_10590 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E5D09_10595 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E5D09_10600 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E5D09_10615 ENOG41063SB peptidase E5D09_10620 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E5D09_10625 ENOG4107QSN dihydrolipoamide acetyltransferase E5D09_10640 ENOG4105E0K tonB-dependent siderophore receptor E5D09_10655 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E5D09_10670 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E5D09_10690 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5D09_10695 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E5D09_10705 ENOG4105D64 Mechanosensitive ion channel E5D09_10715 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E5D09_10720 ENOG4108W2Y isochorismatase E5D09_10730 ENOG4105FBW Monooxygenase E5D09_10735 ENOG4108UZX fmn reductase E5D09_10750 ENOG4105BZU Histidine kinase E5D09_10755 ENOG41062QD Membrane E5D09_10760 ENOG4107QN1 sodium solute E5D09_10770 ENOG4105C94 Transporter E5D09_10780 ENOG4105BZU Histidine kinase E5D09_10785 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E5D09_10790 ENOG4108WUH Transcriptional regulator, TetR family E5D09_10795 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E5D09_10805 ENOG4105RA2 Membrane E5D09_10810 ENOG4105DWF phosphomethylpyrimidine kinase E5D09_10820 ENOG4107RDB Major Facilitator E5D09_10825 ENOG4108UUM single-stranded DNA-binding protein E5D09_10835 ENOG4108UMN azlc family E5D09_10845 ENOG4105C85 amino acid E5D09_10855 ENOG4108JPW Aminotransferase E5D09_10860 ENOG4105C26 Dehydrogenase E5D09_10870 ENOG4105CHJ isochorismatase hydrolase E5D09_10875 ENOG4105EUB pirin domain protein E5D09_10900 ENOG4105D94 Major Facilitator Superfamily E5D09_10905 ENOG4106NZI LysR family Transcriptional regulator E5D09_10925 ENOG4105CPC Aldo Keto reductase E5D09_10930 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) E5D09_10950 ENOG4105KVH Transcriptional regulator E5D09_10960 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein E5D09_10970 ENOG4108Z9I -acetyltransferase E5D09_11030 ENOG4105CUV Homoserine Kinase E5D09_11045 ENOG41061CK Antibiotic biosynthesis monooxygenase E5D09_11075 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) E5D09_11105 ENOG4105CYC Transferase E5D09_11115 ENOG4105E0F Histidine kinase E5D09_11120 ENOG4105DPZ Two component transcriptional regulator (Winged helix family E5D09_11135 ENOG4105PDP Short chain dehydrogenase E5D09_11145 ENOG4105C5H ABC transporter E5D09_11345 ENOG4105DFP Integrase E5D09_11365 ENOG4108IQI permease E5D09_11390 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E5D09_11405 ENOG4105CJN penicillin-binding protein E5D09_11410 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E5D09_11415 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E5D09_11430 ENOG4105DHI Methyltransferase E5D09_11435 ENOG4108JQC penicillin-binding protein 1A E5D09_11460 ENOG4105E4G Type IV pilus E5D09_11480 ENOG4105CBC glutamate synthase E5D09_11485 ENOG4105BZ8 glutamate synthase E5D09_11495 ENOG4108V0P LemA family E5D09_11500 ENOG4105HA9 of methanol dehydrogenase type E5D09_11510 ENOG4105X0D Fimbrial protein E5D09_11520 ENOG4108YSG O-Antigen polymerase E5D09_11525 ENOG4108UQY Iron-storage protein E5D09_11535 ENOG4105KME endoribonuclease L-psp E5D09_11540 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E5D09_11555 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E5D09_11590 ENOG4108VAU general secretion pathway protein G E5D09_11605 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) E5D09_11620 ENOG4107IFA Lipase (EC 3.1.1.3) E5D09_11625 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) E5D09_11630 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) E5D09_11655 ENOG4108JQ1 Dehydrogenase E5D09_11660 ENOG4105CQB FAD linked oxidase domain protein E5D09_11670 ENOG4105VRH Antibiotic biosynthesis monooxygenase E5D09_11675 ENOG4105NF4 modulator of drug activity E5D09_11685 ENOG4107QF7 multi-drug E5D09_11690 ENOG4105EM2 membrane E5D09_11695 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5D09_11700 ENOG4105IPI Membrane E5D09_11705 ENOG4107SKI cobyrinic Acid a,c-diamide synthase E5D09_11735 ENOG4108IQI permease E5D09_11740 ENOG4105D82 Glutamate dehydrogenase E5D09_11745 ENOG4105C8Y Acetylornithine aminotransferase E5D09_11755 ENOG4105C26 Dehydrogenase E5D09_11780 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin E5D09_11840 ENOG4105W87 Cbs domain E5D09_11845 ENOG41067S9 phage shock protein C, PspC E5D09_11855 ENOG4105CSU acyl-Coa dehydrogenase E5D09_11870 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) E5D09_11885 ENOG4105ECY inositol monophosphatase E5D09_11890 ENOG4105C1J atp-dependent rna helicase E5D09_11900 ENOG4105DHJ ABC, transporter E5D09_11905 ENOG4105CY3 ABC transporter, permease E5D09_11915 ENOG4105E3I toluene tolerance E5D09_11925 ENOG4105D7N magnesium and cobalt transport protein CorA E5D09_11930 ENOG4108URH decarboxylase E5D09_11940 ENOG4105MJ2 Competence protein E5D09_11945 ENOG4105CB5 ATP-dependent DNA helicase recG E5D09_11965 ENOG4105C29 acyl-CoA thioesterase E5D09_11970 ENOG4105CK2 sodium dicarboxylate symporter E5D09_11985 ENOG4105KPV Transcriptional regulator E5D09_12000 ENOG4105D7A ATP-binding protein E5D09_12005 ENOG4105C28 cystathionine E5D09_12010 ENOG41089BK Glutamine amido-transferase E5D09_12120 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E5D09_12125 ENOG41067V7 50S ribosomal protein L36 E5D09_12135 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) E5D09_12160 ENOG4105C1G acyl-Coa dehydrogenase E5D09_12195 ENOG4105VKU nucleicacid-binding protein E5D09_12200 ENOG4105DGW oligopeptidase A E5D09_12205 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E5D09_12255 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E5D09_12270 ENOG4107S2Z UPF0761 membrane protein E5D09_12275 ENOG4105CS1 NAD(P)H quinone oxidoreductase E5D09_12305 ENOG4105C9A Phoh family E5D09_12315 ENOG4105E4C Lytic transglycosylase catalytic E5D09_12345 ENOG4105D6S protein involved in catabolism of external DNA E5D09_12350 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase E5D09_12395 ENOG4105C1G acyl-Coa dehydrogenase E5D09_12400 ENOG4108RZE Tetr family transcriptional regulator E5D09_12415 ENOG4107QX3 carboxylase E5D09_12420 ENOG4105C1G acyl-Coa dehydrogenase E5D09_12460 ENOG4105KB2 stringent starvation protein b E5D09_12465 ENOG4107MKT Stringent starvation protein a E5D09_12470 ENOG4108UJD 30S ribosomal protein S9 E5D09_12480 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E5D09_12485 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) E5D09_12490 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) E5D09_12510 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E5D09_12520 ENOG4107RZC phospholipase d E5D09_12530 ENOG4105UYK outer membrane protein a E5D09_12535 ENOG4108KHX Diguanylate cyclase E5D09_12570 ENOG4107QN2 dihydrolipoyl dehydrogenase E5D09_12580 ENOG4107QPB Beta-lactamase domain protein E5D09_12585 ENOG4107U2T alpha beta E5D09_12595 ENOG4105NAU thioesterase Superfamily protein E5D09_12625 ENOG4105K9H YciI-like protein E5D09_12635 ENOG4105DB7 PHP domain protein E5D09_12640 ENOG4105FFC UPF0187 protein E5D09_12650 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E5D09_12655 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E5D09_12660 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E5D09_12665 ENOG4105VIE preprotein translocase, subunit YajC E5D09_12700 ENOG4105BZU Histidine kinase E5D09_12705 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) E5D09_12710 ENOG4105CM2 brancheD-chain amino acid aminotransferase E5D09_12720 ENOG4107BJW polysaccharide deacetylase E5D09_12725 ENOG4105CPK Glycosyl transferase (Group 1 E5D09_12735 ENOG4107T8Q Glycosyl transferase (Group 1 E5D09_12745 ENOG4108SEH involved in lipopolysaccharide biosynthesis E5D09_12750 ENOG4105X1N Glycosyl transferase family 8 E5D09_12775 ENOG4105UGU tonB-dependent Receptor E5D09_12795 ENOG4108VY7 phosphate-starvation-inducible protein PsiE E5D09_12800 ENOG4105CSU acyl-Coa dehydrogenase E5D09_12805 ENOG4105CSU acyl-Coa dehydrogenase E5D09_12815 ENOG4105EB3 Histidine kinase E5D09_12820 ENOG4105E3W Two component transcriptional regulator (Winged helix family E5D09_12825 ENOG4105CNG UPF0061 protein E5D09_12845 ENOG4108WBT adenosyltransferase E5D09_12850 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) E5D09_12860 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) E5D09_12895 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E5D09_12915 ENOG4105D3R alkyl hydroperoxide reductase E5D09_12930 ENOG4105CSH Transporter E5D09_12935 ENOG4108UT2 hemolysin iii E5D09_12965 ENOG4105CHU acetyl-coa acetyltransferase E5D09_12970 ENOG4108R6W Transcriptional regulator, ARAC family E5D09_12980 ENOG4105TW1 Carbohydrate-selective porin OprB E5D09_12985 ENOG4105DZG Dehydrogenase E5D09_12990 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) E5D09_13000 ENOG410814C multidrug resistance protein E5D09_13010 ENOG4105CHU acetyl-coa acetyltransferase E5D09_13020 ENOG4108WHA ompa motb domain protein E5D09_13025 ENOG4105E0Y RtcB Protein E5D09_13030 ENOG4108IQI permease E5D09_13040 ENOG4105C2W permease E5D09_13060 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) E5D09_13070 ENOG4108VX5 3-methyladenine DNA glycosylase E5D09_13075 ENOG4105CHB tonB-dependent Receptor E5D09_13080 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5D09_13095 ENOG4105T95 Thiol disulfide interChange protein E5D09_13100 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) E5D09_13110 ENOG4105K78 MarR family Transcriptional regulator E5D09_13115 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E5D09_13120 ENOG4105KWI UPF0339 protein E5D09_13145 ENOG4108UNF response regulator E5D09_13150 ENOG4105M3Z response regulator E5D09_13155 ENOG4108ZGA chew protein E5D09_13160 ENOG4105C8Q Methyl-accepting chemotaxis E5D09_13165 ENOG4105CBS Chea signal transduction histidine kinase E5D09_13175 ENOG4105D4P Coproporphyrinogen iii oxidase E5D09_13190 ENOG4106HKS Entericidin EcnA/B family E5D09_13200 ENOG4105WD1 Membrane E5D09_13205 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E5D09_13245 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E5D09_13255 ENOG4105EM2 membrane E5D09_13260 ENOG4105C2C drug resistance transporter, Bcr CflA E5D09_13280 ENOG4105BZG amino acid carrier protein E5D09_13285 ENOG4105D78 K07001 NTE family protein E5D09_13290 ENOG4105C7B Threonine dehydratase E5D09_13300 ENOG4105C9K Endothelin-converting enzyme 1 E5D09_13325 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E5D09_13335 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E5D09_13340 ENOG4105DFF Rod shape-determining protein mreb E5D09_13345 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E5D09_13350 ENOG4105VQ7 Rod shape-determining protein MreD E5D09_13355 ENOG4108Z03 MAF-like protein E5D09_13360 ENOG4105C03 ribonuclease E5D09_13370 ENOG4105D8T Acyltransferase E5D09_13380 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein E5D09_13390 ENOG4108X0B nad(p)h dehydrogenase (quinone) E5D09_13415 ENOG4105CF7 AraC family transcriptional regulator E5D09_13435 ENOG4105C85 amino acid E5D09_13440 ENOG4105C7F AcnD-accessory protein PrpF E5D09_13445 ENOG4105CTB Polyprenyl synthetase E5D09_13450 ENOG4105MSB protein, conserved in bacteria E5D09_13465 ENOG4105D78 K07001 NTE family protein E5D09_13485 ENOG4105DIJ Phosphoethanolamine transferase E5D09_13490 ENOG4105XJC Two component transcriptional regulator (Winged helix family E5D09_13495 ENOG4105DHQ Histidine kinase E5D09_13515 ENOG4108M0I Transcriptional regulator E5D09_13535 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E5D09_13555 ENOG4105K8R UPF0145 protein E5D09_13560 ENOG4105K8R UPF0145 protein E5D09_13565 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E5D09_13570 ENOG4105BZS acriflavin resistance protein E5D09_13575 ENOG4105C1P efflux transporter, rnd family, mfp subunit E5D09_13580 ENOG410841Q phosphoesterase PA-phosphatase related protein E5D09_13610 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) E5D09_13625 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E5D09_13630 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E5D09_13635 ENOG4105KVH Transcriptional regulator E5D09_13645 ENOG4105CUB amino acid E5D09_13660 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) E5D09_13665 ENOG41084BA UPF0250 protein E5D09_13670 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5D09_13700 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E5D09_13705 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E5D09_13715 ENOG4105E33 succinate dehydrogenase E5D09_13730 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E5D09_13735 ENOG4105C7S Dehydrogenase E5D09_13740 ENOG4107QN2 dihydrolipoyl dehydrogenase E5D09_13750 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E5D09_13760 ENOG4105CKW Inner membrane protein yedI E5D09_13765 ENOG4105CGZ zinc metallopeptidase E5D09_13770 ENOG4105EEQ Na H antiporter E5D09_13785 ENOG4105PNM synthesis protein E5D09_13800 ENOG41080TK Universal stress protein E5D09_13810 ENOG4108UQ8 endoribonuclease L-psp E5D09_13815 ENOG4108IG5 Transcriptional regulator E5D09_13825 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E5D09_13830 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E5D09_13845 ENOG4105HBR Rna-binding protein E5D09_13855 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E5D09_13860 ENOG4105EEI dihydropteroate synthase E5D09_13920 ENOG4105CSH Transporter E5D09_13925 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) E5D09_13930 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E5D09_13945 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E5D09_13965 ENOG41080IJ Diacylglycerol kinase E5D09_13975 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase E5D09_13980 ENOG4105BZS acriflavin resistance protein E5D09_13995 ENOG4105E4C Lytic transglycosylase catalytic E5D09_14020 ENOG4108RRZ Transcription elongation factor GreB E5D09_14035 ENOG4105CEY Amp-dependent synthetase and ligase E5D09_14060 ENOG4105YCT UPF0386 protein E5D09_14100 ENOG4105BZW Glycerate kinase E5D09_14105 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit E5D09_14110 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) E5D09_14125 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) E5D09_14135 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E5D09_14140 ENOG4105C85 amino acid E5D09_14150 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E5D09_14160 ENOG4105N14 lysine exporter protein LysE YggA E5D09_14165 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5D09_14170 ENOG4105BZJ Electron transfer flavoprotein E5D09_14175 ENOG4105C10 Electron transfer flavoprotein E5D09_14180 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E5D09_14215 ENOG4107KET secretion protein, HlyD family E5D09_14245 ENOG4105D60 lipoprotein releasing system transmembrane protein E5D09_14250 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E5D09_14255 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 E5D09_14265 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E5D09_14270 ENOG4107R6F Alpha Beta Hydrolase Fold protein E5D09_14275 ENOG4108V3E phosphoribosylglycinamide formyltransferase E5D09_14285 ENOG4105C02 permease E5D09_14335 ENOG4105KCK Peptidoglycan-associated lipoprotein E5D09_14340 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) E5D09_14350 ENOG4105M8F Biopolymer transport protein exbD tolR E5D09_14355 ENOG4105E02 MotA TolQ exbB proton channel E5D09_14360 ENOG4107YD3 Thioesterase E5D09_14365 ENOG4105CH2 amidohydrolase E5D09_14385 ENOG4108ETH Formylglycinamide ribotide synthetase E5D09_14390 ENOG4105C2C drug resistance transporter, Bcr CflA E5D09_14395 ENOG4105EGD dinuclear metal center protein, YbgI family E5D09_14400 ENOG4108UKI Enoyl-CoA hydratase E5D09_14415 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E5D09_14430 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) E5D09_14435 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E5D09_14450 ENOG4107R11 Transcriptional regulator E5D09_14455 ENOG4108IJ6 ABC transporter E5D09_14465 ENOG4108I5D sulfate abc transporter E5D09_14475 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E5D09_14480 ENOG4105YAZ 4-amino-4-deoxychorismate lyase E5D09_14485 ENOG4105HHA aminodeoxychorismate lyase E5D09_14500 ENOG4108IYU L-aspartate oxidase E5D09_14505 ENOG4105C0H protease E5D09_14520 ENOG4105C3F Signal peptidase i E5D09_14535 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) E5D09_14545 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) E5D09_14550 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) E5D09_14555 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase E5D09_14560 ENOG4105EMU Dehydrogenase E5D09_14590 ENOG4105F7F Chaperone E5D09_14610 ENOG4105BZU Histidine kinase E5D09_14620 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) E5D09_14630 ENOG4105DTR rard protein E5D09_14665 ENOG4107QS8 (LipO)protein E5D09_14670 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E5D09_14675 ENOG4105EA8 2-Nitropropane dioxygenase E5D09_14705 ENOG4107R8N Glycosyl transferase, family 2 E5D09_14720 ENOG4105CVP deoxyribo-dipyrimidine photolyase E5D09_14725 ENOG4108YZY peptidylprolyl cis-trans isomerase E5D09_14730 ENOG4105CEP NADH dehydrogenase E5D09_14735 ENOG4105DZ1 carboxypeptidase E5D09_14745 ENOG4105E9K Isocitrate dehydrogenase E5D09_14750 ENOG4108R99 pseudouridine synthase E5D09_14775 ENOG4105CBP Major Facilitator E5D09_14780 ENOG4105EGI Transcriptional regulator E5D09_14785 ENOG4108ETY sodium dicarboxylate symporter E5D09_14790 ENOG4105JAB phenazine biosynthesis protein, phzf family E5D09_14820 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) E5D09_14835 ENOG4105D3G Pseudouridine synthase E5D09_14840 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E5D09_14855 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E5D09_14865 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein E5D09_14880 ENOG4108JPW Aminotransferase E5D09_14885 ENOG4105DY8 decarboxylase E5D09_14895 ENOG4105F7P transcriptional regulator AsnC family E5D09_14900 ENOG4107RA9 decarboxylase E5D09_14905 ENOG4105C85 amino acid E5D09_14910 ENOG4105CVA phosphate E5D09_14915 ENOG4105C8U phosphate abc transporter E5D09_14925 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E5D09_14930 ENOG4105ERU peptidase E5D09_14945 ENOG4107QTF adenylosuccinate lyase E5D09_14965 ENOG4108Z0R Transferase E5D09_14970 ENOG4105DZ1 carboxypeptidase E5D09_14990 ENOG4108K5P (LipO)protein E5D09_14995 ENOG4105EJC lysr family transcriptional regulator E5D09_15000 ENOG4105DAN ATP-dependent protease E5D09_15015 ENOG4105DHU Bile acid E5D09_15025 ENOG41066DG (EAL) domain protein E5D09_15035 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E5D09_15045 ENOG4105D22 carbon starvation protein E5D09_15050 ENOG4105VCD cytoplasmic protein E5D09_15060 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E5D09_15090 ENOG4105C2I pirin domain protein E5D09_15100 ENOG4105WWK YheO domain protein E5D09_15115 ENOG4105CEY Amp-dependent synthetase and ligase E5D09_15130 ENOG4108IPW abc transporter atp-binding protein E5D09_15150 ENOG4105C0W non-ribosomal peptide synthetase E5D09_15155 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E5D09_15160 ENOG4105WQI isochorismatase E5D09_15175 ENOG4105BZ1 (ABC) transporter E5D09_15180 ENOG4108JJ7 ABC transporter E5D09_15195 ENOG4105E4F Isochorismate synthase E5D09_15210 ENOG4105NX3 Membrane E5D09_15230 ENOG4105EUJ GTP cyclohydrolase i E5D09_15240 ENOG4105C7W Xanthine dehydrogenase E5D09_15270 ENOG4105CD8 aminopeptidase N E5D09_15275 ENOG4105DDQ anthranilate synthase E5D09_15285 ENOG4105DUX Transporter E5D09_15290 ENOG4105C5F glutamine synthetase E5D09_15300 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) E5D09_15335 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E5D09_15340 ENOG4107QNR UPF0135 protein E5D09_15345 ENOG4105C0H protease E5D09_15355 ENOG4105C6K Malic enzyme E5D09_15360 ENOG4105BZU Histidine kinase E5D09_15365 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E5D09_15370 ENOG4105SYT Methylenetetrahydrofolate reductase E5D09_15375 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) E5D09_15390 ENOG4107QPN acyl-Coa dehydrogenase E5D09_15395 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E5D09_15400 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) E5D09_15410 ENOG4107RNU major facilitator superfamily MFS_1 E5D09_15440 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E5D09_15445 ENOG4105CE9 30S ribosomal protein S2 E5D09_15485 ENOG4105CVE Lytic murein transglycosylase E5D09_15490 ENOG4105CNI cell division protein FtsW E5D09_15505 ENOG4105E3A (ABC) transporter E5D09_15510 ENOG4105DA5 (ABC) transporter E5D09_15540 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E5D09_15550 ENOG4105ENT Efflux transporter rnd family, mfp subunit E5D09_15560 ENOG4105E89 ABC transporter E5D09_15565 ENOG4105DSP amino acid AbC transporter E5D09_15570 ENOG4106YG3 ABC transporter E5D09_15575 ENOG4108JEH abc transporter atp-binding protein E5D09_15585 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E5D09_15590 ENOG4105CFP Peptidase U32 E5D09_15595 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E5D09_15600 ENOG4105JAB phenazine biosynthesis protein, phzf family E5D09_15605 ENOG4105DP0 ferredoxin-NADP reductase E5D09_15610 ENOG4108R96 Methyltransferase, YaeB family E5D09_15620 ENOG4107QHF type ii secretion system protein e E5D09_15630 ENOG4105XJC Two component transcriptional regulator (Winged helix family E5D09_15635 ENOG4105DHQ Histidine kinase E5D09_15645 ENOG4105M6F mutator MutT protein E5D09_15655 ENOG4105BZ4 penicillin-binding protein E5D09_15660 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) E5D09_15665 ENOG4105VUT cytoplasmic protein E5D09_15670 ENOG4107QYG anthranilate phosphoribosyltransferase E5D09_15680 ENOG4105CK2 sodium dicarboxylate symporter E5D09_15685 ENOG4105C1G acyl-Coa dehydrogenase E5D09_15690 ENOG4105NIV Esterase E5D09_15695 ENOG4105CQC Prephenate dehydratase E5D09_15700 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase E5D09_15710 ENOG4105CIN aminoacyl-histidine dipeptidase E5D09_15715 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) E5D09_15745 ENOG4105M08 Membrane E5D09_15750 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E5D09_15760 ENOG4105VEQ Cold shock protein E5D09_15765 ENOG4105C1J atp-dependent rna helicase E5D09_15775 ENOG41069NU Nitroreductase E5D09_15810 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E5D09_15825 ENOG4105C5I Dehydrogenase E5D09_15830 ENOG4105ERG peptidase m48, ste24p E5D09_15835 ENOG4105KTH gatB Yqey E5D09_15840 ENOG4105VCC 30S ribosomal protein S21 E5D09_15865 ENOG4105D9P serine threonine protein kinase E5D09_15955 ENOG4105EVZ LysR family transcriptional regulator E5D09_15960 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E5D09_15965 ENOG4105C26 Dehydrogenase E5D09_16000 ENOG4105H4F exported protein E5D09_16030 ENOG4105D6U Sodium Glutamate Symporter E5D09_16040 ENOG4105JXH GntR family transcriptional regulator E5D09_16095 ENOG4105CSH Transporter E5D09_16120 ENOG4105CEB Aspartate aminotransferase E5D09_16140 ENOG4105F1S paraquat-inducible protein a E5D09_16145 ENOG4105DY2 Paraquat-inducible protein b E5D09_16155 ENOG4105VT2 5-hydroxyisourate hydrolase E5D09_16195 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E5D09_16205 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E5D09_16210 ENOG4105DHQ Histidine kinase E5D09_16215 ENOG4105ETX regulatoR E5D09_16265 ENOG4105CK2 sodium dicarboxylate symporter E5D09_16275 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E5D09_16280 ENOG4108UMI ABC transporter, permease E5D09_16285 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E5D09_16295 ENOG4105C12 Phosphoribosylglycinamide synthetase E5D09_16300 ENOG4105DC1 bifunctional purine biosynthesis protein purh E5D09_16305 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) E5D09_16355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E5D09_16360 ENOG4105CDU Replicative dna helicase E5D09_16385 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E5D09_16390 ENOG4105CCU oxidase (Subunit III) E5D09_16395 ENOG4105BZ9 Cytochrome C oxidase, subunit I E5D09_16400 ENOG4105E2S oxidase) subunit II E5D09_16425 ENOG4107BJW polysaccharide deacetylase E5D09_16430 ENOG4105CND Glycosyl transferase, family 2 E5D09_16435 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD E5D09_16445 ENOG4105DEN Luciferase family E5D09_16480 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E5D09_16495 ENOG4105C1G acyl-Coa dehydrogenase E5D09_16505 ENOG4108MEJ flavin reductase domain protein E5D09_16510 ENOG4105D06 uba thif-type nad fad binding protein E5D09_16530 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E5D09_16535 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E5D09_16545 ENOG4105C08 Histidine kinase E5D09_16550 ENOG4105EEX Two component transcriptional regulator (Winged helix family E5D09_16560 ENOG4105CFQ glutamine synthetase E5D09_16575 ENOG4107S74 Lysophospholipid transporter LplT E5D09_16580 ENOG4105CFU surface antigen E5D09_16600 ENOG4107QIJ Aconitate hydratase 2 E5D09_16610 ENOG4105EYW Ion transport protein E5D09_16615 ENOG4105F27 Major Facilitator E5D09_16630 ENOG4105DZ2 Transcriptional regulator E5D09_16665 ENOG4105K8N protein family UPF0079, ATPase E5D09_16670 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) E5D09_16680 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) E5D09_16685 ENOG4108TZV Membrane E5D09_16690 ENOG4108RCM Nitroreductase E5D09_16715 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E5D09_16720 ENOG4107FQ9 ethanolamine ammonia-lyase E5D09_16725 ENOG4105CPD ethanolamine ammonia-lyase E5D09_16730 ENOG4107R55 ethanolamine transporter E5D09_16740 ENOG4107RR1 TRANSCRIPTIONal E5D09_16750 ENOG4105C0A alcohol dehydrogenase E5D09_16755 ENOG4107QUV Domain protein E5D09_16780 ENOG4105CD8 aminopeptidase N E5D09_16795 ENOG4108D1K outer membrane usher protein E5D09_16820 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) E5D09_16825 ENOG4105EW9 transcriptional regulator AsnC family E5D09_16840 ENOG4105R8C Transcriptional regulator E5D09_16850 ENOG4105CUY Mechanosensitive ion channel E5D09_16885 ENOG4105CNM Receptor E5D09_16905 ENOG4105C5H ABC transporter E5D09_16910 ENOG41081QV Universal stress protein E5D09_16925 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic E5D09_16935 ENOG4105DKK Benzoate E5D09_16940 ENOG4105EW9 transcriptional regulator AsnC family E5D09_16945 ENOG4108NIW Leucine export protein LeuE E5D09_16950 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E5D09_16955 ENOG4105C5Q Transcriptional regulator E5D09_16965 ENOG4105CHU acetyl-coa acetyltransferase E5D09_16970 ENOG4105CHR reductase E5D09_17005 ENOG4107QMP dna polymerase iii subunits gamma and tau E5D09_17010 ENOG4105HSS phospholipase C E5D09_17020 ENOG4105C0A alcohol dehydrogenase E5D09_17060 ENOG4105CBC glutamate synthase E5D09_17370 ENOG4105E4C Lytic transglycosylase catalytic E5D09_17425 ENOG4105KT5 UmuD protein E5D09_17440 ENOG4105D8G Major Facilitator superfamily E5D09_17450 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E5D09_17455 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E5D09_17480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E5D09_17500 ENOG4107QZF nitrite reductase NADPH large subunit E5D09_17505 ENOG4108IFG nitrite reductase, (NAD(P)H) E5D09_17540 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) E5D09_17545 ENOG4105CVM Molybdenum cofactor synthesis domain protein E5D09_17555 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E5D09_17560 ENOG4105T38 integral membrane protein E5D09_17580 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) E5D09_17585 ENOG4105CMR udp-glucose 4-epimerase E5D09_17645 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E5D09_17650 ENOG4105CUX Signal transduction histidine kinase E5D09_17675 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) E5D09_17680 ENOG4105KNE Phosphatidate cytidylyltransferase E5D09_17690 ENOG4105DZP Membrane-associated zinc metalloprotease E5D09_17695 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E5D09_17715 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E5D09_17730 ENOG4105Y3E Modulates RecA activity (By similarity) E5D09_17740 ENOG4105VEJ Heat shock protein E5D09_17745 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E5D09_17770 ENOG4105F7P transcriptional regulator AsnC family E5D09_17780 ENOG4105C85 amino acid E5D09_17795 ENOG4105CHH sulfate transporter E5D09_17800 ENOG4108RAV Conserved protein E5D09_17805 ENOG4105D8V Glucose sorbosone dehydrogenase E5D09_17835 ENOG4105DM4 PTS System E5D09_17840 ENOG4105DE4 1-phosphofructokinase E5D09_17845 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E5D09_17870 ENOG4105CWM branched-chain amino acid transport system II carrier protein E5D09_17875 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E5D09_17880 ENOG4105CC0 LysR family Transcriptional regulator E5D09_17890 ENOG4105M2J Glutaredoxin E5D09_17895 ENOG4105C8Y Acetylornithine aminotransferase E5D09_17900 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E5D09_17925 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E5D09_17935 ENOG41068P6 UPF0319 protein E5D09_17950 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E5D09_17955 ENOG4105C4M (Ubiquinol oxidase) subunit I E5D09_17965 ENOG4105PV3 Inner membrane protein yqiJ E5D09_17980 ENOG4105E0K tonB-dependent siderophore receptor E5D09_17990 ENOG4105HDD phospholipase E5D09_17995 ENOG4105CZN Potassium uptake protein E5D09_18005 ENOG4105C7B Threonine dehydratase E5D09_18035 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) E5D09_18040 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E5D09_18050 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E5D09_18065 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5D09_18110 ENOG4107VMU Membrane E5D09_18115 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E5D09_18125 ENOG4107QP7 CoA-transferase subunit A E5D09_18130 ENOG4107QNJ CoA-transferase subunit B E5D09_18135 ENOG4105CHU acetyl-coa acetyltransferase E5D09_18140 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase E5D09_18145 ENOG4105F2Z 3-oxoadipate enol-lactonase E5D09_18150 ENOG4105D2S major facilitator superfamily E5D09_18155 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase E5D09_18160 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta E5D09_18165 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha E5D09_18170 ENOG4105FF2 Type I DHQase E5D09_18175 ENOG4106JPM 3-dehydroshikimate dehydratase E5D09_18180 ENOG4105TW1 Carbohydrate-selective porin OprB E5D09_18185 ENOG4105DZG Dehydrogenase E5D09_18195 ENOG4105MD1 YeeE YedE family protein E5D09_18210 ENOG4107HP6 Transcriptional regulator E5D09_18215 ENOG4108PTX LysR family Transcriptional regulator E5D09_18220 ENOG4105C1G acyl-Coa dehydrogenase E5D09_18245 ENOG4105DNH Major Facilitator E5D09_18255 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) E5D09_18275 ENOG4105FUY alpha subunit E5D09_18285 ENOG4105CHR reductase E5D09_18305 ENOG4105F11 amine oxidase E5D09_18315 ENOG4105C26 Dehydrogenase E5D09_18320 ENOG4105F2Z 3-oxoadipate enol-lactonase E5D09_18325 ENOG4105CHU acetyl-coa acetyltransferase E5D09_18330 ENOG4107QNJ CoA-transferase subunit B E5D09_18335 ENOG4107QP7 CoA-transferase subunit A E5D09_18345 ENOG4105NN7 muconolactone delta-isomerase E5D09_18350 ENOG4105DTQ mandelate racemase muconate lactonizing E5D09_18355 ENOG4108KB2 LysR family Transcriptional regulator E5D09_18365 ENOG4107EJG GntR family transcriptional regulator E5D09_18425 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E5D09_18445 ENOG4108JA2 transcriptioN-repair coupling factor E5D09_18460 ENOG4106I9N Immunoglobulin G binding protein A E5D09_18530 ENOG4105E2A Dehydrogenase E5D09_18555 ENOG4105C4W S-formylglutathione hydrolase E5D09_18570 ENOG4108I6A alcohol dehydrogenase E5D09_18580 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E5D09_18590 ENOG4108WUH Transcriptional regulator, TetR family E5D09_18600 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E5D09_18645 ENOG4107RZZ dna polymerase iii epsilon subunit E5D09_18670 ENOG4105DIJ Phosphoethanolamine transferase E5D09_18720 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5D09_18725 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E5D09_18795 ENOG4105C0B DNA polymerase III (alpha subunit) E5D09_18805 ENOG4106J5W DNA polymerase III (alpha subunit) E5D09_18850 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E5D09_18875 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E5D09_18905 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E5D09_19065 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) E5D09_19150 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) E5D09_19155 ENOG4107QJE Chromosome Partitioning Protein E5D09_19170 ENOG4108NE4 E5D09_19190 ENOG4105KT5 UmuD protein E5D09_19205 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E5D09_19300 ENOG4108HWY Beta-lactamase E5D09_19310 ENOG4107RRE RNA-directed DNA polymerase