locus-tag	class	description
E5D09_00010	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_00015	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_00025	COG1960	acyl-CoA dehydrogenase activity
E5D09_00040	COG0318	PFAM AMP-dependent synthetase and ligase
E5D09_00115	COG0583	DNA-binding transcription factor activity
E5D09_00140	COG1566	PFAM secretion protein HlyD family protein
E5D09_00180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5D09_00200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5D09_00235	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5D09_00240	COG2814	Major facilitator Superfamily
E5D09_00250	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5D09_00260	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_00265	COG3384	dioxygenase
E5D09_00275	COG3971	2-oxopent-4-enoate hydratase activity
E5D09_00290	COG0477	Major facilitator Superfamily
E5D09_00295	COG1960	acyl-CoA dehydrogenase activity
E5D09_00300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5D09_00305	COG1846	Transcriptional regulator
E5D09_00310	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_00315	COG0129	dihydroxy-acid dehydratase activity
E5D09_00325	COG0583	DNA-binding transcription factor activity
E5D09_00330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E5D09_00340	COG2084	Dehydrogenase
E5D09_00345	COG2207	Transcriptional regulator
E5D09_00350	COG1064	alcohol dehydrogenase
E5D09_00365	COG1120	ATPase activity
E5D09_00385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5D09_00455	COG4372	Transposase
E5D09_00485	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_00490	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_00500	COG2207	Transcriptional regulator
E5D09_00510	COG2205	protein histidine kinase activity
E5D09_00515	COG0745	RESPONSE REGULATOR receiver
E5D09_00520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5D09_00525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5D09_00590	COG3539	Fimbrial protein
E5D09_00615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E5D09_00625	COG0753	catalase activity
E5D09_00640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5D09_00650	COG3293	Transposase
E5D09_00715	COG1535	isochorismatase
E5D09_00715	COG3433	isochorismatase activity
E5D09_00720	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_00725	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E5D09_00730	COG4149	molybdate abc transporter
E5D09_00735	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5D09_00745	COG4638	Rieske (2fe-2S)
E5D09_00750	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5D09_00755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5D09_00755	COG0543	2 iron, 2 sulfur cluster binding
E5D09_00770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5D09_00780	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_00785	COG0412	Dienelactone hydrolase
E5D09_00795	COG2207	Transcriptional regulator
E5D09_00800	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_00805	COG2610	gluconate transmembrane transporter activity
E5D09_00810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5D09_00845	COG0583	DNA-binding transcription factor activity
E5D09_00860	COG2031	fatty acid transporter
E5D09_00865	COG0183	Belongs to the thiolase family
E5D09_00870	COG0583	DNA-binding transcription factor activity
E5D09_00875	COG0583	DNA-binding transcription factor activity
E5D09_00890	COG1027	Aspartate ammonia-lyase
E5D09_00900	COG0477	Major facilitator Superfamily
E5D09_00920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5D09_00925	COG4521	taurine ABC transporter
E5D09_00950	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
E5D09_00955	COG1733	regulation of RNA biosynthetic process
E5D09_00960	COG3708	Transcriptional regulator
E5D09_00960	COG2207	Transcriptional regulator
E5D09_00975	COG0730	response to heat
E5D09_00995	COG3781	membrane
E5D09_01000	COG1063	alcohol dehydrogenase
E5D09_01010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5D09_01015	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5D09_01020	COG0022	dehydrogenase e1 component
E5D09_01025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E5D09_01030	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5D09_01060	COG0133	tryptophan synthase activity
E5D09_01070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5D09_01105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5D09_01130	COG2226	methyltransferase
E5D09_01185	COG0842	Transport permease protein
E5D09_01190	COG0842	Transport permease protein
E5D09_01195	COG1131	(ABC) transporter
E5D09_01210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5D09_01215	COG4773	Receptor
E5D09_01235	COG0730	response to heat
E5D09_01240	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5D09_01255	COG0406	alpha-ribazole phosphatase activity
E5D09_01305	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5D09_01315	COG4264	IucA IucC family
E5D09_01320	COG4264	IucA IucC family
E5D09_01325	COG2814	Major facilitator Superfamily
E5D09_01340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5D09_01355	COG1960	acyl-CoA dehydrogenase activity
E5D09_01360	COG1960	acyl-CoA dehydrogenase activity
E5D09_01365	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5D09_01370	COG2207	Transcriptional regulator
E5D09_01375	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5D09_01380	COG0776	regulation of translation
E5D09_01405	COG0822	iron-sulfur transferase activity
E5D09_01410	COG0316	Belongs to the HesB IscA family
E5D09_01440	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5D09_01460	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5D09_01465	COG0702	epimerase
E5D09_01500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5D09_01510	COG0339	signal peptide processing
E5D09_01555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E5D09_01560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E5D09_01600	COG0776	regulation of translation
E5D09_01620	COG0590	tRNA wobble adenosine to inosine editing
E5D09_01650	COG2165	general secretion pathway protein
E5D09_01665	COG0084	hydrolase, TatD family'
E5D09_01685	COG1663	tetraacyldisaccharide 4'-kinase activity
E5D09_01690	COG1132	(ABC) transporter
E5D09_01700	COG0811	peptide transport
E5D09_01705	COG1475	DNA binding
E5D09_01710	COG1192	Involved in chromosome partitioning
E5D09_01720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E5D09_01735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E5D09_01740	COG0191	fructose-bisphosphate aldolase activity
E5D09_01760	COG0424	maF-like protein
E5D09_01765	COG2850	peptidyl-arginine hydroxylation
E5D09_01775	COG0640	Transcriptional regulator
E5D09_01785	COG3619	membrane
E5D09_01790	COG3122	Protein conserved in bacteria
E5D09_01795	COG1132	(ABC) transporter
E5D09_01815	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5D09_01820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5D09_01830	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5D09_01830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E5D09_01830	COG0506	proline dehydrogenase activity
E5D09_01835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
E5D09_01850	COG3698	Phosphodiester glycosidase
E5D09_01860	COG2353	YceI-like domain
E5D09_01870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5D09_01920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5D09_01920	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5D09_01945	COG3539	Fimbrial protein
E5D09_01950	COG3121	Chaperone
E5D09_01980	COG0697	spore germination
E5D09_01990	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E5D09_02000	COG0583	DNA-binding transcription factor activity
E5D09_02020	COG1309	transcriptional regulator
E5D09_02035	COG1522	sequence-specific DNA binding
E5D09_02045	COG1126	abc transporter atp-binding protein
E5D09_02050	COG0765	amino acid transport
E5D09_02055	COG0765	amino acid transport
E5D09_02095	COG1464	Belongs to the NlpA lipoprotein family
E5D09_02105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5D09_02110	COG2011	ABC-type metal ion transport system permease component
E5D09_02115	COG0012	GTP binding
E5D09_02140	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E5D09_02180	COG0386	Belongs to the glutathione peroxidase family
E5D09_02190	COG0436	Aminotransferase
E5D09_02230	COG3634	alkyl hydroperoxide reductase activity
E5D09_02245	COG0583	DNA-binding transcription factor activity
E5D09_02250	COG0798	PFAM Bile acid sodium symporter
E5D09_02255	COG0640	Transcriptional regulator
E5D09_02270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E5D09_02280	COG0583	DNA-binding transcription factor activity
E5D09_02290	COG1953	Uracil, thiamine, allantoin
E5D09_02300	COG2175	clavaminate synthase activity
E5D09_02305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5D09_02310	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E5D09_02315	COG4521	taurine ABC transporter
E5D09_02325	COG0477	Major facilitator Superfamily
E5D09_02350	COG1271	oxidase subunit
E5D09_02355	COG1294	oxidase, subunit
E5D09_02365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5D09_02385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5D09_02405	COG3052	prosthetic group binding
E5D09_02410	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E5D09_02420	COG0583	DNA-binding transcription factor activity
E5D09_02430	COG2814	Major facilitator Superfamily
E5D09_02450	COG1346	cytolysis
E5D09_02460	COG0583	DNA-binding transcription factor activity
E5D09_02465	COG0625	glutathione transferase activity
E5D09_02470	COG0625	glutathione transferase activity
E5D09_02475	COG0583	DNA-binding transcription factor activity
E5D09_02490	COG1045	serine acetyltransferase
E5D09_02495	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5D09_02500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E5D09_02505	COG1280	lysine exporter protein (LysE YggA)
E5D09_02520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5D09_02525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5D09_02535	COG0765	amino acid transport
E5D09_02540	COG0765	amino acid transport
E5D09_02560	COG2205	protein histidine kinase activity
E5D09_02560	COG0784	Response regulator, receiver
E5D09_02580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5D09_02600	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_02645	COG0583	DNA-binding transcription factor activity
E5D09_02665	COG0318	PFAM AMP-dependent synthetase and ligase
E5D09_02670	COG1309	transcriptional regulator
E5D09_02675	COG1960	acyl-CoA dehydrogenase activity
E5D09_02680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5D09_02685	COG1024	Enoyl-CoA hydratase
E5D09_02700	COG0583	DNA-binding transcription factor activity
E5D09_02715	COG1960	acyl-CoA dehydrogenase activity
E5D09_02725	COG2814	Major facilitator Superfamily
E5D09_02735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5D09_02740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5D09_02745	COG2814	Major facilitator Superfamily
E5D09_02760	COG3316	Transposase and inactivated derivatives
E5D09_02790	COG3657	addiction module killer protein
E5D09_02795	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5D09_02805	COG2801	Transposase and inactivated derivatives
E5D09_02835	COG3316	Transposase and inactivated derivatives
E5D09_02875	COG3209	COG3209 Rhs family protein
E5D09_02880	COG3501	Rhs element vgr protein
E5D09_02915	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5D09_02935	COG2814	Major facilitator Superfamily
E5D09_02955	COG0598	Magnesium transport protein CorA
E5D09_02960	COG1560	Kdo2-lipid A biosynthetic process
E5D09_02970	COG5006	permease, DMT superfamily
E5D09_02975	COG1522	sequence-specific DNA binding
E5D09_02990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E5D09_03035	COG1137	ATPase activity
E5D09_03040	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E5D09_03050	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E5D09_03055	COG0517	IMP dehydrogenase activity
E5D09_03055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5D09_03095	COG1733	regulation of RNA biosynthetic process
E5D09_03100	COG2814	Major facilitator Superfamily
E5D09_03140	COG3293	Transposase
E5D09_03145	COG1278	Cold shock
E5D09_03150	COG1280	lysine exporter protein (LysE YggA)
E5D09_03180	COG1570	exodeoxyribonuclease VII activity
E5D09_03265	COG2871	sodium ion transport
E5D09_03275	COG0583	DNA-binding transcription factor activity
E5D09_03280	COG4638	Rieske (2fe-2S)
E5D09_03285	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E5D09_03290	COG0543	2 iron, 2 sulfur cluster binding
E5D09_03290	COG0633	Ferredoxin
E5D09_03295	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_03300	COG3135	benzoate transporter
E5D09_03305	COG2814	Major facilitator Superfamily
E5D09_03320	COG1643	Atp-dependent helicase
E5D09_03325	COG0450	alkyl hydroperoxide reductase
E5D09_03335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E5D09_03345	COG3634	alkyl hydroperoxide reductase activity
E5D09_03370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5D09_03375	COG0625	glutathione transferase activity
E5D09_03385	COG2885	chlorophyll binding
E5D09_03435	COG1765	OsmC-like protein
E5D09_03445	COG0667	Aldo Keto reductase
E5D09_03460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5D09_03475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E5D09_03495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5D09_03505	COG3038	cytochrome b561
E5D09_03510	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5D09_03515	COG2252	PERMEase
E5D09_03525	COG2072	flavoprotein involved in K transport
E5D09_03540	COG1741	Belongs to the pirin family
E5D09_03545	COG1309	transcriptional regulator
E5D09_03555	COG0300	oxidoreductase activity
E5D09_03560	COG2072	flavoprotein involved in K transport
E5D09_03565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E5D09_03610	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5D09_03625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5D09_03640	COG2814	Major facilitator Superfamily
E5D09_03645	COG1024	Enoyl-CoA hydratase
E5D09_03650	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_03660	COG1960	acyl-CoA dehydrogenase activity
E5D09_03685	COG2186	Transcriptional regulator
E5D09_03690	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_03700	COG4948	Mandelate Racemase Muconate Lactonizing
E5D09_03705	COG2271	Major facilitator Superfamily
E5D09_03710	COG2721	sulfolactate sulfo-lyase activity
E5D09_03715	COG0697	spore germination
E5D09_03750	COG1113	amino acid transport
E5D09_03770	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_03790	COG0531	amino acid
E5D09_03800	COG1113	amino acid transport
E5D09_03840	COG3209	COG3209 Rhs family protein
E5D09_03845	COG3501	Rhs element vgr protein
E5D09_03860	COG4269	membrane
E5D09_03875	COG1902	pentaerythritol trinitrate reductase activity
E5D09_03875	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5D09_03885	COG2203	Gaf domain
E5D09_03885	COG3706	GGDEF domain
E5D09_03885	COG4251	negative regulation of phosphorylation
E5D09_03885	COG5001	Diguanylate cyclase
E5D09_03895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5D09_03915	COG4172	Belongs to the ABC transporter superfamily
E5D09_03920	COG4239	(ABC) transporter, permease
E5D09_03925	COG4174	ABC transporter (Permease)
E5D09_03935	COG1388	LysM domain
E5D09_03935	COG0741	lytic transglycosylase activity
E5D09_03935	COG1388	LysM domain
E5D09_03935	COG0741	lytic transglycosylase activity
E5D09_03940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5D09_03980	COG0583	DNA-binding transcription factor activity
E5D09_03985	COG1279	arginine transmembrane transporter activity
E5D09_04005	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5D09_04010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5D09_04015	COG0006	proline dipeptidase activity
E5D09_04135	COG1196	nuclear chromosome segregation
E5D09_04135	COG0739	heme binding
E5D09_04135	COG0741	lytic transglycosylase activity
E5D09_04400	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E5D09_04420	COG3384	dioxygenase
E5D09_04430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5D09_04435	COG2878	Part of a membrane complex involved in electron transport
E5D09_04440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5D09_04465	COG0768	penicillin binding
E5D09_04470	COG0742	ribosomal rna small subunit methyltransferase
E5D09_04485	COG0830	nickel cation binding
E5D09_04495	COG0804	urea catabolic process
E5D09_04535	COG1253	flavin adenine dinucleotide binding
E5D09_04545	COG2851	Citrate transporter
E5D09_04595	COG1773	rubredoxin
E5D09_04600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5D09_04610	COG0583	DNA-binding transcription factor activity
E5D09_04640	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E5D09_04645	COG4181	ATPase activity
E5D09_04690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E5D09_04710	COG0306	phosphate transporter
E5D09_04720	COG3958	Transketolase
E5D09_04725	COG3959	Transketolase, thiamine diphosphate binding domain
E5D09_04730	COG2271	Major facilitator Superfamily
E5D09_04735	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_04740	COG0583	DNA-binding transcription factor activity
E5D09_04760	COG2223	nitrite transmembrane transporter activity
E5D09_04765	COG2207	Transcriptional regulator
E5D09_04770	COG2066	Belongs to the glutaminase family
E5D09_04775	COG0242	peptide deformylase activity
E5D09_04780	COG0477	Major facilitator Superfamily
E5D09_04790	COG0028	Belongs to the TPP enzyme family
E5D09_04795	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_04805	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_04810	COG2267	carboxylic ester hydrolase activity
E5D09_04820	COG2271	Major facilitator Superfamily
E5D09_04835	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_04855	COG1414	Transcriptional regulator
E5D09_04870	COG1024	Enoyl-CoA hydratase
E5D09_04880	COG1215	transferase activity, transferring glycosyl groups
E5D09_04885	COG0726	polysaccharide deacetylase
E5D09_04885	COG1649	PFAM Uncharacterised BCR, COG1649
E5D09_04895	COG4681	YaeQ
E5D09_04905	COG0523	cobalamin synthesis protein
E5D09_04915	COG1607	acyl-coa hydrolase
E5D09_04925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5D09_04930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5D09_04935	COG1309	transcriptional regulator
E5D09_04960	COG2040	homocysteine
E5D09_04965	COG0531	amino acid
E5D09_04990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5D09_04995	COG0477	Major facilitator Superfamily
E5D09_05055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5D09_05125	COG0582	viral genome integration into host DNA
E5D09_05135	COG0405	Gamma-glutamyltransferase
E5D09_05140	COG2814	Major facilitator Superfamily
E5D09_05150	COG2050	protein possibly involved in aromatic compounds catabolism
E5D09_05165	COG1090	epimerase
E5D09_05185	COG0420	3'-5' exonuclease activity
E5D09_05210	COG0735	belongs to the Fur family
E5D09_05215	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5D09_05240	COG0121	glutamine amidotransferase
E5D09_05255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5D09_05265	COG0210	DNA helicase
E5D09_05270	COG2885	chlorophyll binding
E5D09_05275	COG0204	Acyl-transferase
E5D09_05290	COG2894	cell division
E5D09_05310	COG1280	lysine exporter protein (LysE YggA)
E5D09_05315	COG1674	ftsk spoiiie
E5D09_05320	COG0492	ferredoxin-NADP+ reductase activity
E5D09_05325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E5D09_05335	COG0456	acetyltransferase
E5D09_05400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5D09_05400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E5D09_05420	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_05440	COG0473	3-isopropylmalate dehydrogenase activity
E5D09_05445	COG0583	DNA-binding transcription factor activity
E5D09_05465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5D09_05490	COG0564	pseudouridine synthase activity
E5D09_05500	COG0358	DNA primase activity
E5D09_05515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E5D09_05540	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5D09_05570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E5D09_05580	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5D09_05580	COG0352	thiamine-phosphate diphosphorylase activity
E5D09_05580	COG0351	phosphomethylpyrimidine kinase
E5D09_05585	COG1652	LysM domain
E5D09_05610	COG1399	metal-binding, possibly nucleic acid-binding protein
E5D09_05615	COG3101	peptidyl-lysine hydroxylation
E5D09_05620	COG0009	L-threonylcarbamoyladenylate synthase
E5D09_05625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E5D09_05630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5D09_05645	COG4106	trans-aconitate 2-methyltransferase activity
E5D09_05660	COG0596	Alpha beta hydrolase
E5D09_05660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5D09_05660	COG2226	methyltransferase
E5D09_05665	COG1877	trehalose-phosphatase activity
E5D09_05670	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E5D09_05675	COG2223	nitrite transmembrane transporter activity
E5D09_05695	COG1196	nuclear chromosome segregation
E5D09_05705	COG0730	response to heat
E5D09_05720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5D09_05730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5D09_05790	COG0489	protein tyrosine kinase activity
E5D09_05800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5D09_05800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5D09_05830	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E5D09_05835	COG2081	HI0933 family
E5D09_05845	COG0668	transmembrane transport
E5D09_05865	COG0583	DNA-binding transcription factor activity
E5D09_05885	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5D09_05890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5D09_05920	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E5D09_05945	COG3706	GGDEF domain
E5D09_05955	COG2205	protein histidine kinase activity
E5D09_05960	COG0745	RESPONSE REGULATOR receiver
E5D09_05980	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5D09_06025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5D09_06030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E5D09_06040	COG0583	DNA-binding transcription factor activity
E5D09_06050	COG0583	DNA-binding transcription factor activity
E5D09_06070	COG0583	DNA-binding transcription factor activity
E5D09_06075	COG1053	succinate dehydrogenase
E5D09_06090	COG1309	transcriptional regulator
E5D09_06095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E5D09_06100	COG2814	Major facilitator Superfamily
E5D09_06105	COG1960	acyl-CoA dehydrogenase activity
E5D09_06110	COG0583	DNA-binding transcription factor activity
E5D09_06115	COG1063	alcohol dehydrogenase
E5D09_06150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5D09_06155	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5D09_06160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5D09_06180	COG2132	Multicopper oxidase
E5D09_06190	COG0561	phosphatase activity
E5D09_06195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5D09_06220	COG1214	PFAM Peptidase M22, glycoprotease
E5D09_06260	COG3293	Transposase
E5D09_06275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5D09_06285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5D09_06290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5D09_06295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5D09_06355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5D09_06365	COG1846	Transcriptional regulator
E5D09_06370	COG1764	response to oxidative stress
E5D09_06395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5D09_06395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5D09_06410	COG0037	tRNA processing
E5D09_06420	COG0248	Ppx GppA phosphatase
E5D09_06450	COG0072	phenylalanine-tRNA ligase activity
E5D09_06475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E5D09_06490	COG1238	metal cluster binding
E5D09_06495	COG0625	glutathione transferase activity
E5D09_06515	COG0318	PFAM AMP-dependent synthetase and ligase
E5D09_06520	COG3028	Belongs to the UPF0307 family
E5D09_06525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5D09_06545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5D09_06550	COG0617	tRNA 3'-terminal CCA addition
E5D09_06555	COG1555	photosystem II stabilization
E5D09_06560	COG3956	TIGRFAM MazG family protein
E5D09_06570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5D09_06590	COG2205	protein histidine kinase activity
E5D09_06590	COG0784	Response regulator, receiver
E5D09_06590	COG5002	protein histidine kinase activity
E5D09_06595	COG1024	Enoyl-CoA hydratase
E5D09_06600	COG2084	Dehydrogenase
E5D09_06605	COG3622	Belongs to the hyi family
E5D09_06620	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E5D09_06625	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E5D09_06630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E5D09_06635	COG0697	spore germination
E5D09_06645	COG2814	Major facilitator Superfamily
E5D09_06655	COG2072	flavoprotein involved in K transport
E5D09_06660	COG0492	ferredoxin-NADP+ reductase activity
E5D09_06665	COG0431	NADPH-dependent FMN reductase
E5D09_06670	COG0798	PFAM Bile acid sodium symporter
E5D09_06680	COG0640	Transcriptional regulator
E5D09_06725	COG2132	Multicopper oxidase
E5D09_06740	COG2205	protein histidine kinase activity
E5D09_06825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5D09_06835	COG0583	DNA-binding transcription factor activity
E5D09_06845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5D09_06855	COG0084	hydrolase, TatD family'
E5D09_06870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5D09_06905	COG0440	acetolactate synthase activity
E5D09_06910	COG0028	Belongs to the TPP enzyme family
E5D09_06935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5D09_06940	COG1136	(ABC) transporter
E5D09_06940	COG0577	efflux transmembrane transporter activity
E5D09_06945	COG1538	Outer membrane efflux protein
E5D09_06960	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E5D09_06965	COG1162	GTPase activity
E5D09_06975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E5D09_07015	COG1426	Protein conserved in bacteria
E5D09_07050	COG0793	Belongs to the peptidase S41A family
E5D09_07075	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_07080	COG3265	gluconokinase activity
E5D09_07090	COG0800	Aldolase
E5D09_07100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E5D09_07105	COG0280	phosphate acetyltransferase
E5D09_07105	COG0857	belongs to the CobB CobQ family
E5D09_07110	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E5D09_07110	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E5D09_07130	COG0740	serine-type endopeptidase activity
E5D09_07165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5D09_07175	COG2813	Specifically methylates the guanine in position
E5D09_07175	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5D09_07275	COG0788	formyltetrahydrofolate deformylase activity
E5D09_07290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5D09_07295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5D09_07300	COG4651	solute:proton antiporter activity
E5D09_07300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5D09_07320	COG0724	RNA recognition motif
E5D09_07325	COG0210	DNA helicase
E5D09_07350	COG1733	regulation of RNA biosynthetic process
E5D09_07370	COG1280	lysine exporter protein (LysE YggA)
E5D09_07375	COG1560	Kdo2-lipid A biosynthetic process
E5D09_07385	COG1301	dicarboxylic acid transport
E5D09_07410	COG0252	asparaginase activity
E5D09_07440	COG0473	3-isopropylmalate dehydrogenase activity
E5D09_07495	COG0583	DNA-binding transcription factor activity
E5D09_07515	COG0625	glutathione transferase activity
E5D09_07520	COG2378	regulation of single-species biofilm formation
E5D09_07525	COG0546	phosphoglycolate phosphatase activity
E5D09_07540	COG1530	ribonuclease E activity
E5D09_07560	COG0583	DNA-binding transcription factor activity
E5D09_07565	COG3316	Transposase and inactivated derivatives
E5D09_07570	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_07575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5D09_07585	COG0534	Mate efflux family protein
E5D09_07600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5D09_07640	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E5D09_07645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5D09_07660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5D09_07670	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
E5D09_07670	COG0644	oxidoreductase
E5D09_07680	COG0425	Belongs to the sulfur carrier protein TusA family
E5D09_07685	COG4535	Mg2 and Co2 transporter CorC
E5D09_07695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5D09_07715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5D09_07720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E5D09_07720	COG0475	glutathione-regulated potassium exporter activity
E5D09_07735	COG0484	heat shock protein binding
E5D09_07740	COG0789	Transcriptional regulator
E5D09_07745	COG0598	Magnesium transport protein CorA
E5D09_07765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5D09_07770	COG1074	ATP-dependent DNA helicase activity
E5D09_07775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E5D09_07795	COG2226	methyltransferase
E5D09_07805	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E5D09_07820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5D09_07835	COG2111	Na H antiporter
E5D09_07835	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E5D09_07840	COG1006	Multisubunit Na H antiporter MnhC subunit
E5D09_07845	COG0651	ATP synthesis coupled electron transport
E5D09_07855	COG2212	antiporter activity
E5D09_07875	COG0195	Participates in both transcription termination and antitermination
E5D09_07925	COG0237	dephospho-CoA kinase activity
E5D09_07935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5D09_07950	COG0497	DNA recombination
E5D09_07960	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E5D09_07990	COG2169	Transcriptional regulator
E5D09_07990	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5D09_07995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5D09_08055	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
E5D09_08070	COG0326	Molecular chaperone. Has ATPase activity
E5D09_08085	COG2056	Na+-H+ antiporter family
E5D09_08185	COG0546	phosphoglycolate phosphatase activity
E5D09_08190	COG1716	ATPase activity
E5D09_08235	COG0181	hydroxymethylbilane synthase activity
E5D09_08245	COG3275	phosphorelay sensor kinase activity
E5D09_08270	COG0697	spore germination
E5D09_08295	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5D09_08300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E5D09_08305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5D09_08310	COG0772	Belongs to the SEDS family
E5D09_08335	COG4974	Belongs to the 'phage' integrase family
E5D09_08340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5D09_08350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5D09_08360	COG2197	response regulator
E5D09_08375	COG0793	Belongs to the peptidase S41A family
E5D09_08380	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5D09_08385	COG0795	lipopolysaccharide-transporting ATPase activity
E5D09_08425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5D09_08425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E5D09_08435	COG0004	ammonium transporteR
E5D09_08440	COG0347	Belongs to the P(II) protein family
E5D09_08450	COG0606	chelatase, subunit chli
E5D09_08460	COG0659	secondary active sulfate transmembrane transporter activity
E5D09_08465	COG0589	response to stress
E5D09_08505	COG0606	chelatase, subunit chli
E5D09_08510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5D09_08520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5D09_08535	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E5D09_08550	COG0318	PFAM AMP-dependent synthetase and ligase
E5D09_08560	COG0477	Major facilitator Superfamily
E5D09_08565	COG2860	membrane
E5D09_08575	COG1253	flavin adenine dinucleotide binding
E5D09_08585	COG2814	Major facilitator Superfamily
E5D09_08595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5D09_08630	COG0655	NAD(P)H dehydrogenase (quinone) activity
E5D09_08640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5D09_08675	COG1309	transcriptional regulator
E5D09_08725	COG0758	DNA mediated transformation
E5D09_08735	COG0697	spore germination
E5D09_08740	COG1309	transcriptional regulator
E5D09_08755	COG0386	Belongs to the glutathione peroxidase family
E5D09_08820	COG1121	(ABC) transporter
E5D09_08825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E5D09_08830	COG1280	lysine exporter protein (LysE YggA)
E5D09_08835	COG2837	iron assimilation
E5D09_08840	COG0281	malic enzyme
E5D09_08885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5D09_08885	COG0519	Catalyzes the synthesis of GMP from XMP
E5D09_08890	COG4399	Belongs to the UPF0754 family
E5D09_08895	COG2259	Doxx family
E5D09_08900	COG0586	Pfam SNARE associated Golgi protein
E5D09_08915	COG1192	Involved in chromosome partitioning
E5D09_08925	COG0271	Belongs to the BolA IbaG family
E5D09_08965	COG3321	synthase
E5D09_08965	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
E5D09_08965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E5D09_08965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5D09_08970	COG1960	acyl-CoA dehydrogenase activity
E5D09_08980	COG2197	response regulator
E5D09_08990	COG3916	Acyl-homoserine-lactone synthase
E5D09_08995	COG0477	Major facilitator Superfamily
E5D09_09000	COG1024	Enoyl-CoA hydratase
E5D09_09005	COG1024	Enoyl-CoA hydratase
E5D09_09010	COG1960	acyl-CoA dehydrogenase activity
E5D09_09015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5D09_09035	COG1113	amino acid transport
E5D09_09040	COG1113	amino acid transport
E5D09_09045	COG0251	oxidation-reduction process
E5D09_09060	COG1522	sequence-specific DNA binding
E5D09_09085	COG0564	pseudouridine synthase activity
E5D09_09130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5D09_09145	COG1802	Transcriptional regulator
E5D09_09155	COG1448	Aminotransferase
E5D09_09160	COG0277	FAD linked oxidase domain protein
E5D09_09170	COG2186	Transcriptional regulator
E5D09_09180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5D09_09185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5D09_09200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E5D09_09205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5D09_09215	COG1215	transferase activity, transferring glycosyl groups
E5D09_09220	COG0438	transferase activity, transferring glycosyl groups
E5D09_09235	COG5039	Polysaccharide pyruvyl transferase
E5D09_09245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E5D09_09275	COG0728	peptidoglycan biosynthetic process
E5D09_09280	COG3023	N-Acetylmuramoyl-L-alanine amidase
E5D09_09335	COG0546	phosphoglycolate phosphatase activity
E5D09_09340	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_09360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5D09_09365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5D09_09370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5D09_09375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5D09_09380	COG1116	anion transmembrane transporter activity
E5D09_09385	COG1309	transcriptional regulator
E5D09_09390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5D09_09400	COG0196	riboflavin kinase activity
E5D09_09405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5D09_09415	COG1047	Peptidyl-prolyl cis-trans
E5D09_09455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5D09_09510	COG2951	lytic endotransglycosylase activity
E5D09_09515	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E5D09_09535	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5D09_09545	COG0671	phosphoesterase, PA-phosphatase related
E5D09_09550	COG0861	Integral membrane protein TerC family
E5D09_09560	COG0754	glutathionylspermidine amidase activity
E5D09_09570	COG0402	S-adenosylhomocysteine deaminase activity
E5D09_09585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5D09_09590	COG1230	cation diffusion facilitator family transporter
E5D09_09605	COG0706	membrane insertase activity
E5D09_09620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E5D09_09630	COG0592	DNA-directed DNA polymerase activity
E5D09_09640	COG0187	DNA topoisomerase II activity
E5D09_09650	COG0586	Pfam SNARE associated Golgi protein
E5D09_09655	COG0488	(ABC) transporter
E5D09_09685	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E5D09_09690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E5D09_09735	COG0733	neurotransmitter:sodium symporter activity
E5D09_09745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5D09_09770	COG0583	DNA-binding transcription factor activity
E5D09_09775	COG2233	PERMEase
E5D09_09790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5D09_09825	COG2814	Major facilitator Superfamily
E5D09_09830	COG0656	L-ascorbic acid biosynthetic process
E5D09_09835	COG0583	DNA-binding transcription factor activity
E5D09_09850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5D09_09855	COG1064	alcohol dehydrogenase
E5D09_09860	COG2818	Glycosylase
E5D09_09875	COG1194	a g-specific adenine glycosylase
E5D09_09895	COG2983	Belongs to the UPF0260 family
E5D09_09900	COG2133	pyrroloquinoline quinone binding
E5D09_09905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5D09_09910	COG2116	formate transmembrane transporter activity
E5D09_09930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5D09_09935	COG1335	isochorismatase
E5D09_09940	COG0385	Bile acid
E5D09_09945	COG0534	Mate efflux family protein
E5D09_09950	COG1683	Conserved Protein
E5D09_09970	COG0625	glutathione transferase activity
E5D09_09980	COG1113	amino acid transport
E5D09_09990	COG0523	cobalamin synthesis protein
E5D09_10000	COG2188	Transcriptional regulator
E5D09_10030	COG0010	Belongs to the arginase family
E5D09_10045	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5D09_10065	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
E5D09_10070	COG0732	type I restriction modification DNA specificity domain
E5D09_10100	COG4584	PFAM Integrase catalytic
E5D09_10130	COG2826	transposase and inactivated derivatives, IS30 family
E5D09_10150	COG0673	inositol 2-dehydrogenase activity
E5D09_10155	COG1324	tolerance protein
E5D09_10205	COG2826	transposase and inactivated derivatives, IS30 family
E5D09_10210	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E5D09_10270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5D09_10280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E5D09_10285	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E5D09_10390	COG0534	Mate efflux family protein
E5D09_10395	COG0436	Aminotransferase
E5D09_10400	COG2733	membrane
E5D09_10415	COG2918	glutathione biosynthetic process
E5D09_10425	COG3501	Rhs element vgr protein
E5D09_10430	COG3409	Peptidoglycan-binding domain 1 protein
E5D09_10430	COG1388	LysM domain
E5D09_10430	COG5632	N-Acetylmuramoyl-L-alanine amidase
E5D09_10460	COG3150	esterase
E5D09_10470	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E5D09_10480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E5D09_10490	COG2233	PERMEase
E5D09_10530	COG3706	GGDEF domain
E5D09_10545	COG1393	Belongs to the ArsC family
E5D09_10550	COG0708	Exodeoxyribonuclease III
E5D09_10570	COG0189	ligase activity
E5D09_10590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E5D09_10600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E5D09_10615	COG4942	peptidase
E5D09_10625	COG0508	dehydrogenase complex catalyzes the overall conversion of
E5D09_10635	COG2119	membrane
E5D09_10640	COG4774	siderophore transport
E5D09_10645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5D09_10645	COG0426	domain, Protein
E5D09_10670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5D09_10690	COG1902	pentaerythritol trinitrate reductase activity
E5D09_10695	COG1519	Transferase
E5D09_10700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5D09_10705	COG0668	transmembrane transport
E5D09_10715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5D09_10720	COG1335	isochorismatase
E5D09_10725	COG1522	sequence-specific DNA binding
E5D09_10750	COG2198	Histidine kinase
E5D09_10750	COG0784	Response regulator, receiver
E5D09_10750	COG2205	protein histidine kinase activity
E5D09_10755	COG3162	membrane
E5D09_10760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5D09_10770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5D09_10780	COG3706	GGDEF domain
E5D09_10785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5D09_10790	COG1309	transcriptional regulator
E5D09_10810	COG0352	thiamine-phosphate diphosphorylase activity
E5D09_10810	COG0351	phosphomethylpyrimidine kinase
E5D09_10810	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E5D09_10820	COG2814	Major facilitator Superfamily
E5D09_10835	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E5D09_10845	COG1113	amino acid transport
E5D09_10855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5D09_10860	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_10870	COG1335	isochorismatase
E5D09_10900	COG2814	Major facilitator Superfamily
E5D09_10905	COG0583	DNA-binding transcription factor activity
E5D09_10925	COG0667	Aldo Keto reductase
E5D09_10950	COG1733	regulation of RNA biosynthetic process
E5D09_10960	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5D09_10970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5D09_11030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E5D09_11045	COG2329	Antibiotic biosynthesis monooxygenase
E5D09_11075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5D09_11105	COG0427	acetyl-CoA hydrolase
E5D09_11120	COG0745	RESPONSE REGULATOR receiver
E5D09_11135	COG4221	oxidoreductase activity
E5D09_11145	COG0488	(ABC) transporter
E5D09_11345	COG0582	viral genome integration into host DNA
E5D09_11365	COG0833	amino acid
E5D09_11410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5D09_11415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5D09_11430	COG2226	methyltransferase
E5D09_11480	COG0070	glutamate synthase
E5D09_11480	COG0069	glutamate synthase activity
E5D09_11480	COG0067	glutamate synthase
E5D09_11485	COG0493	'glutamate synthase
E5D09_11495	COG1704	LemA family
E5D09_11500	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E5D09_11520	COG3307	-O-antigen
E5D09_11540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5D09_11555	COG0194	GDP metabolic process
E5D09_11605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5D09_11625	COG5380	lipid catabolic process
E5D09_11630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5D09_11655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5D09_11660	COG0277	FAD linked oxidase domain protein
E5D09_11670	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
E5D09_11675	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5D09_11690	COG1289	transmembrane transporter activity
E5D09_11700	COG0628	permease
E5D09_11705	COG1192	Involved in chromosome partitioning
E5D09_11735	COG0833	amino acid
E5D09_11740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5D09_11745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5D09_11755	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_11795	COG0583	DNA-binding transcription factor activity
E5D09_11840	COG0517	IMP dehydrogenase activity
E5D09_11845	COG1983	PspC domain protein
E5D09_11855	COG1960	acyl-CoA dehydrogenase activity
E5D09_11870	COG0408	coproporphyrinogen oxidase activity
E5D09_11890	COG0513	Belongs to the DEAD box helicase family
E5D09_11900	COG1127	ABC transporter
E5D09_11905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E5D09_11915	COG2854	intermembrane phospholipid transfer
E5D09_11925	COG0598	Magnesium transport protein CorA
E5D09_11935	COG0494	nUDIX hydrolase
E5D09_11940	COG1040	competence protein
E5D09_11945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5D09_11965	COG1946	Acyl-CoA thioesterase
E5D09_11970	COG1301	dicarboxylic acid transport
E5D09_11985	COG1959	2 iron, 2 sulfur cluster binding
E5D09_11990	COG1017	nitric oxide dioxygenase activity
E5D09_11990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5D09_12000	COG0433	COG0433 Predicted ATPase
E5D09_12005	COG0626	cystathionine gamma-synthase activity
E5D09_12125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5D09_12135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5D09_12160	COG1960	acyl-CoA dehydrogenase activity
E5D09_12165	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E5D09_12195	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
E5D09_12200	COG0339	signal peptide processing
E5D09_12205	COG0557	exoribonuclease II activity
E5D09_12255	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5D09_12265	COG0697	spore germination
E5D09_12270	COG1295	ribonuclease BN
E5D09_12305	COG1702	phosphate starvation-inducible protein PhoH
E5D09_12315	COG1196	nuclear chromosome segregation
E5D09_12315	COG0741	lytic transglycosylase activity
E5D09_12315	COG0739	heme binding
E5D09_12345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E5D09_12350	COG1183	phosphatidylcholine synthase activity
E5D09_12395	COG1960	acyl-CoA dehydrogenase activity
E5D09_12400	COG1309	transcriptional regulator
E5D09_12415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5D09_12420	COG1960	acyl-CoA dehydrogenase activity
E5D09_12460	COG2969	positive regulation of protein catabolic process
E5D09_12470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E5D09_12485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5D09_12490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E5D09_12510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5D09_12520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5D09_12525	COG1408	metallophosphoesterase
E5D09_12535	COG2199	diguanylate cyclase activity
E5D09_12580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5D09_12580	COG3453	Protein conserved in bacteria
E5D09_12595	COG1607	acyl-coa hydrolase
E5D09_12625	COG2350	Protein conserved in bacteria
E5D09_12635	COG0613	PHP domain protein
E5D09_12640	COG3781	membrane
E5D09_12650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5D09_12655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5D09_12665	COG1862	Preprotein translocase
E5D09_12700	COG2205	protein histidine kinase activity
E5D09_12705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E5D09_12720	COG0726	polysaccharide deacetylase
E5D09_12725	COG0438	transferase activity, transferring glycosyl groups
E5D09_12735	COG0438	transferase activity, transferring glycosyl groups
E5D09_12750	COG1442	glycosyl transferase family 8
E5D09_12800	COG1960	acyl-CoA dehydrogenase activity
E5D09_12805	COG1960	acyl-CoA dehydrogenase activity
E5D09_12815	COG2205	protein histidine kinase activity
E5D09_12820	COG0745	RESPONSE REGULATOR receiver
E5D09_12825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E5D09_12845	COG2096	Adenosyltransferase
E5D09_12860	COG0133	tryptophan synthase activity
E5D09_12895	COG0285	dihydrofolate synthase activity
E5D09_12915	COG0450	alkyl hydroperoxide reductase
E5D09_12930	COG0477	Major facilitator Superfamily
E5D09_12935	COG1272	protein, Hemolysin III
E5D09_12965	COG0183	Belongs to the thiolase family
E5D09_12970	COG2207	Transcriptional regulator
E5D09_12990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5D09_13010	COG0183	Belongs to the thiolase family
E5D09_13020	COG2885	chlorophyll binding
E5D09_13020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E5D09_13025	COG1690	Belongs to the RtcB family
E5D09_13030	COG0833	amino acid
E5D09_13040	COG2233	PERMEase
E5D09_13070	COG2094	Belongs to the DNA glycosylase MPG family
E5D09_13075	COG4772	TonB-dependent receptor
E5D09_13080	COG1902	pentaerythritol trinitrate reductase activity
E5D09_13095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E5D09_13100	COG0354	folic acid binding
E5D09_13110	COG3189	MarR family transcriptional regulator
E5D09_13115	COG2824	Alkylphosphonate utilization operon protein PhnA
E5D09_13120	COG3422	double-strand break repair
E5D09_13160	COG0840	transmembrane signaling receptor activity
E5D09_13175	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5D09_13190	COG5510	response to toxic substance
E5D09_13200	COG2832	Protein of unknown function (DUF454)
E5D09_13205	COG1376	ErfK ybiS ycfS ynhG family protein
E5D09_13255	COG1289	transmembrane transporter activity
E5D09_13260	COG2814	Major facilitator Superfamily
E5D09_13280	COG1115	amino acid carrier protein
E5D09_13285	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5D09_13290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5D09_13295	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E5D09_13300	COG3590	peptidase
E5D09_13325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5D09_13335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5D09_13340	COG1077	Cell shape determining protein MreB Mrl
E5D09_13345	COG1792	Involved in formation and maintenance of cell shape
E5D09_13350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E5D09_13355	COG0424	maF-like protein
E5D09_13360	COG1530	ribonuclease E activity
E5D09_13370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5D09_13390	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5D09_13415	COG2207	Transcriptional regulator
E5D09_13435	COG1113	amino acid transport
E5D09_13440	COG2828	Protein conserved in bacteria
E5D09_13445	COG0142	geranyltranstransferase activity
E5D09_13450	COG2315	Protein conserved in bacteria
E5D09_13465	COG1752	Esterase of the alpha-beta hydrolase superfamily
E5D09_13485	COG2194	sulfuric ester hydrolase activity
E5D09_13490	COG0745	RESPONSE REGULATOR receiver
E5D09_13495	COG0642	Histidine kinase
E5D09_13505	COG0004	ammonium transporteR
E5D09_13515	COG0583	DNA-binding transcription factor activity
E5D09_13535	COG0525	valine-tRNA ligase activity
E5D09_13545	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_13555	COG0393	Putative heavy-metal-binding
E5D09_13560	COG0393	Putative heavy-metal-binding
E5D09_13565	COG1538	Outer membrane efflux protein
E5D09_13575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5D09_13580	COG0671	phosphoesterase, PA-phosphatase related
E5D09_13610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E5D09_13625	COG1648	precorrin-2 dehydrogenase activity
E5D09_13625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5D09_13630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E5D09_13635	COG1733	regulation of RNA biosynthetic process
E5D09_13645	COG0531	amino acid
E5D09_13660	COG0321	lipoyl(octanoyl) transferase activity
E5D09_13665	COG2921	Belongs to the UPF0250 family
E5D09_13700	COG2009	succinate dehydrogenase
E5D09_13705	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E5D09_13710	COG1053	succinate dehydrogenase
E5D09_13715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E5D09_13740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5D09_13760	COG2354	Protein conserved in bacteria
E5D09_13765	COG2321	neutral zinc metallopeptidase
E5D09_13785	COG2843	Capsule synthesis protein
E5D09_13800	COG0589	response to stress
E5D09_13810	COG0251	oxidation-reduction process
E5D09_13815	COG1309	transcriptional regulator
E5D09_13830	COG0505	Belongs to the CarA family
E5D09_13855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5D09_13860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5D09_13920	COG0477	Major facilitator Superfamily
E5D09_13925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5D09_13945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5D09_13970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5D09_13975	COG0584	glycerophosphoryl diester phosphodiesterase
E5D09_13995	COG0741	lytic transglycosylase activity
E5D09_14020	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5D09_14035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5D09_14060	COG3811	Belongs to the UPF0386 family
E5D09_14085	COG0778	Nitroreductase
E5D09_14100	COG1929	Belongs to the glycerate kinase type-1 family
E5D09_14105	COG0243	molybdopterin cofactor binding
E5D09_14110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E5D09_14115	COG3339	Conserved Protein
E5D09_14125	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
E5D09_14140	COG1113	amino acid transport
E5D09_14150	COG0019	diaminopimelate decarboxylase activity
E5D09_14160	COG1280	lysine exporter protein (LysE YggA)
E5D09_14165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5D09_14195	COG0463	Glycosyl transferase, family 2
E5D09_14215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5D09_14245	COG4591	ABC-type transport system involved in lipoprotein release permease component
E5D09_14250	COG1136	(ABC) transporter
E5D09_14255	COG0658	competence protein
E5D09_14255	COG2333	competence protein COMEC
E5D09_14265	COG0616	signal peptide processing
E5D09_14265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E5D09_14270	COG0596	Alpha beta hydrolase
E5D09_14275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5D09_14285	COG0628	permease
E5D09_14320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5D09_14340	COG0823	Involved in the tonB-independent uptake of proteins
E5D09_14360	COG0824	Thioesterase
E5D09_14365	COG1473	amidohydrolase
E5D09_14385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5D09_14385	COG0047	phosphoribosylformylglycinamidine synthase activity
E5D09_14390	COG2814	Major facilitator Superfamily
E5D09_14395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5D09_14400	COG1024	Enoyl-CoA hydratase
E5D09_14405	COG1051	belongs to the nudix hydrolase family
E5D09_14405	COG1056	cytidyltransferase-related domain
E5D09_14415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5D09_14430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E5D09_14445	COG4625	pathogenesis
E5D09_14450	COG0583	DNA-binding transcription factor activity
E5D09_14455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E5D09_14460	COG4208	sulfate ABC transporter
E5D09_14465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E5D09_14475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E5D09_14480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5D09_14485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E5D09_14505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5D09_14520	COG0681	Belongs to the peptidase S26 family
E5D09_14535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5D09_14545	COG1381	Involved in DNA repair and RecF pathway recombination
E5D09_14550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E5D09_14560	COG4221	oxidoreductase activity
E5D09_14590	COG0443	Heat shock 70 kDa protein
E5D09_14620	COG0556	nucleotide-excision repair
E5D09_14675	COG2070	2-Nitropropane dioxygenase
E5D09_14705	COG1215	transferase activity, transferring glycosyl groups
E5D09_14720	COG0415	Belongs to the DNA photolyase family
E5D09_14730	COG1252	NADH dehydrogenase
E5D09_14735	COG1686	Belongs to the peptidase S11 family
E5D09_14750	COG1187	pseudouridine synthase activity
E5D09_14775	COG0477	Major facilitator Superfamily
E5D09_14780	COG0583	DNA-binding transcription factor activity
E5D09_14795	COG0612	Peptidase, M16
E5D09_14820	COG0352	thiamine-phosphate diphosphorylase activity
E5D09_14855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E5D09_14865	COG2249	NAD(P)H dehydrogenase (quinone) activity
E5D09_14880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E5D09_14885	COG0076	glutamate decarboxylase activity
E5D09_14895	COG1522	sequence-specific DNA binding
E5D09_14900	COG3961	Belongs to the TPP enzyme family
E5D09_14905	COG1113	amino acid transport
E5D09_14910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E5D09_14915	COG0573	inorganic phosphate transmembrane transporter activity
E5D09_14925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5D09_14930	COG0616	signal peptide processing
E5D09_14965	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E5D09_14970	COG1686	Belongs to the peptidase S11 family
E5D09_14995	COG0583	DNA-binding transcription factor activity
E5D09_15000	COG1067	ATP-dependent peptidase activity
E5D09_15025	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E5D09_15045	COG1966	Carbon starvation protein
E5D09_15050	COG2879	small protein
E5D09_15060	COG2130	NADP-dependent
E5D09_15090	COG1741	Belongs to the pirin family
E5D09_15100	COG2964	Protein conserved in bacteria
E5D09_15115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5D09_15120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5D09_15125	COG4605	iron ion homeostasis
E5D09_15130	COG4604	ABC transporter, ATP-binding protein
E5D09_15135	COG4607	ABC-type enterochelin transport system periplasmic component
E5D09_15150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5D09_15155	COG1021	2,3-dihydroxybenzoate-AMP ligase
E5D09_15160	COG3433	isochorismatase activity
E5D09_15160	COG1535	isochorismatase
E5D09_15175	COG1132	(ABC) transporter
E5D09_15180	COG5265	(ABC) transporter
E5D09_15185	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
E5D09_15195	COG1169	isochorismate synthase
E5D09_15210	COG3739	integral membrane protein
E5D09_15240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5D09_15270	COG0308	aminopeptidase N
E5D09_15275	COG0512	Glutamine amidotransferase of anthranilate synthase
E5D09_15285	COG3104	oligopeptide transport
E5D09_15300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E5D09_15335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E5D09_15340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E5D09_15345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5D09_15365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5D09_15370	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5D09_15375	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E5D09_15390	COG1960	acyl-CoA dehydrogenase activity
E5D09_15395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E5D09_15400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5D09_15410	COG2223	nitrite transmembrane transporter activity
E5D09_15440	COG0024	Methionine aminopeptidase
E5D09_15445	COG0052	Belongs to the universal ribosomal protein uS2 family
E5D09_15460	COG2207	Transcriptional regulator
E5D09_15485	COG2951	lytic endotransglycosylase activity
E5D09_15490	COG0772	Belongs to the SEDS family
E5D09_15505	COG0842	Transport permease protein
E5D09_15510	COG1131	(ABC) transporter
E5D09_15540	COG1538	Outer membrane efflux protein
E5D09_15550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E5D09_15565	COG4215	(ABC) transporter
E5D09_15570	COG4160	amino acid transport
E5D09_15575	COG4598	ABC transporter
E5D09_15585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5D09_15595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5D09_15610	COG1720	tRNA m6t6A37 methyltransferase activity
E5D09_15630	COG0745	RESPONSE REGULATOR receiver
E5D09_15635	COG0642	Histidine kinase
E5D09_15645	COG0494	nUDIX hydrolase
E5D09_15655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E5D09_15660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5D09_15665	COG3139	Protein of unknown function (DUF1315)
E5D09_15670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5D09_15680	COG1301	dicarboxylic acid transport
E5D09_15685	COG1960	acyl-CoA dehydrogenase activity
E5D09_15690	COG2819	hydrolase of the alpha beta superfamily
E5D09_15700	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5D09_15710	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5D09_15715	COG1234	tRNA 3'-trailer cleavage
E5D09_15745	COG2363	Small membrane protein
E5D09_15765	COG0513	Belongs to the DEAD box helicase family
E5D09_15775	COG0778	Nitroreductase
E5D09_15805	COG1286	toxin biosynthetic process
E5D09_15830	COG4783	chaperone-mediated protein folding
E5D09_15835	COG1610	YqeY-like protein
E5D09_15840	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5D09_16000	COG3111	PFAM Bacterial OB fold (BOF) protein
E5D09_16025	COG3243	poly(R)-hydroxyalkanoic acid synthase
E5D09_16030	COG0786	glutamate:sodium symporter activity
E5D09_16040	COG2186	Transcriptional regulator
E5D09_16095	COG0477	Major facilitator Superfamily
E5D09_16125	COG2985	domain, Protein
E5D09_16140	COG2995	paraquat-inducible protein a
E5D09_16145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E5D09_16145	COG3008	intermembrane lipid transfer
E5D09_16155	COG2351	hydroxyisourate hydrolase activity
E5D09_16195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5D09_16205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5D09_16210	COG0642	Histidine kinase
E5D09_16215	COG0745	RESPONSE REGULATOR receiver
E5D09_16235	COG1794	racemase activity, acting on amino acids and derivatives
E5D09_16265	COG1301	dicarboxylic acid transport
E5D09_16275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5D09_16280	COG2011	ABC-type metal ion transport system permease component
E5D09_16285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5D09_16290	COG1464	Belongs to the NlpA lipoprotein family
E5D09_16295	COG0151	Belongs to the GarS family
E5D09_16300	COG0138	bifunctional purine biosynthesis protein purh
E5D09_16305	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E5D09_16345	COG1305	Transglutaminase-like
E5D09_16355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5D09_16360	COG0305	Participates in initiation and elongation during chromosome replication
E5D09_16385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E5D09_16395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E5D09_16400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E5D09_16425	COG0726	polysaccharide deacetylase
E5D09_16425	COG1649	PFAM Uncharacterised BCR, COG1649
E5D09_16430	COG1215	transferase activity, transferring glycosyl groups
E5D09_16435	COG3658	cytochrome
E5D09_16445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E5D09_16495	COG1960	acyl-CoA dehydrogenase activity
E5D09_16500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E5D09_16505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5D09_16530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E5D09_16535	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E5D09_16545	COG2205	protein histidine kinase activity
E5D09_16550	COG0745	RESPONSE REGULATOR receiver
E5D09_16555	COG3293	Transposase
E5D09_16560	COG0174	glutamine synthetase
E5D09_16580	COG0729	surface antigen
E5D09_16610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5D09_16615	COG2814	Major facilitator Superfamily
E5D09_16630	COG0583	DNA-binding transcription factor activity
E5D09_16645	COG1187	pseudouridine synthase activity
E5D09_16665	COG0802	atpase or kinase
E5D09_16670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E5D09_16680	COG1923	regulation of RNA biosynthetic process
E5D09_16685	COG0697	spore germination
E5D09_16715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E5D09_16715	COG0519	Catalyzes the synthesis of GMP from XMP
E5D09_16720	COG4302	ethanolamine ammonia-lyase activity
E5D09_16725	COG4303	Ethanolamine ammonia lyase large subunit
E5D09_16730	COG0531	amino acid
E5D09_16750	COG1454	alcohol dehydrogenase
E5D09_16755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5D09_16780	COG0308	aminopeptidase N
E5D09_16820	COG1605	Chorismate mutase
E5D09_16840	COG1309	transcriptional regulator
E5D09_16850	COG0668	transmembrane transport
E5D09_16885	COG4773	Receptor
E5D09_16905	COG0488	(ABC) transporter
E5D09_16910	COG0589	response to stress
E5D09_16925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5D09_16935	COG3135	benzoate transporter
E5D09_16940	COG1522	sequence-specific DNA binding
E5D09_16950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E5D09_16955	COG0583	DNA-binding transcription factor activity
E5D09_16965	COG0183	Belongs to the thiolase family
E5D09_17005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5D09_17015	COG0824	Thioesterase
E5D09_17020	COG1454	alcohol dehydrogenase
E5D09_17030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5D09_17060	COG0069	glutamate synthase activity
E5D09_17260	COG5410	chromosome segregation
E5D09_17355	COG1598	PFAM Uncharacterised protein family UPF0150
E5D09_17370	COG0741	lytic transglycosylase activity
E5D09_17370	COG0739	heme binding
E5D09_17370	COG1196	nuclear chromosome segregation
E5D09_17440	COG2814	Major facilitator Superfamily
E5D09_17455	COG0511	ligase activity, forming carbon-carbon bonds
E5D09_17475	COG1116	anion transmembrane transporter activity
E5D09_17475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5D09_17480	COG0745	RESPONSE REGULATOR receiver
E5D09_17500	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5D09_17500	COG2146	nitrite reductase [NAD(P)H] activity
E5D09_17505	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5D09_17510	COG0243	molybdopterin cofactor binding
E5D09_17520	COG0243	molybdopterin cofactor binding
E5D09_17525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5D09_17540	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5D09_17540	COG0315	cyclic pyranopterin monophosphate synthase activity
E5D09_17545	COG0303	'Molybdopterin
E5D09_17555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5D09_17560	COG0697	spore germination
E5D09_17580	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
E5D09_17585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5D09_17645	COG2204	response regulator
E5D09_17650	COG3852	Histidine kinase
E5D09_17675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5D09_17680	COG0575	Belongs to the CDS family
E5D09_17695	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E5D09_17715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E5D09_17730	COG2137	regulation of response to DNA damage stimulus
E5D09_17740	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5D09_17745	COG1011	Hydrolase
E5D09_17770	COG1522	sequence-specific DNA binding
E5D09_17780	COG1113	amino acid transport
E5D09_17795	COG0659	secondary active sulfate transmembrane transporter activity
E5D09_17800	COG2135	peptidase activity
E5D09_17835	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
E5D09_17835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5D09_17835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5D09_17840	COG1105	Belongs to the carbohydrate kinase PfkB family
E5D09_17845	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5D09_17845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5D09_17875	COG0024	Methionine aminopeptidase
E5D09_17880	COG0583	DNA-binding transcription factor activity
E5D09_17890	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E5D09_17895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5D09_17900	COG0516	GMP reductase activity
E5D09_17900	COG0517	IMP dehydrogenase activity
E5D09_17925	COG0552	protein localization to endoplasmic reticulum
E5D09_17935	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
E5D09_17945	COG4890	Cyd operon protein YbgT
E5D09_17950	COG1294	oxidase, subunit
E5D09_17965	COG1585	Membrane protein implicated in regulation of membrane protease activity
E5D09_17975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5D09_17980	COG4774	siderophore transport
E5D09_17995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5D09_18000	COG0569	domain protein
E5D09_18005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5D09_18035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E5D09_18040	COG0542	response to heat
E5D09_18050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5D09_18065	COG1902	pentaerythritol trinitrate reductase activity
E5D09_18065	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5D09_18110	COG2323	membrane
E5D09_18115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E5D09_18125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5D09_18130	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5D09_18135	COG0183	Belongs to the thiolase family
E5D09_18140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E5D09_18145	COG0596	Alpha beta hydrolase
E5D09_18150	COG2271	Major facilitator Superfamily
E5D09_18155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E5D09_18160	COG3485	protocatechuate 3,4-dioxygenase
E5D09_18165	COG3485	protocatechuate 3,4-dioxygenase
E5D09_18170	COG0710	3-dehydroquinate dehydratase activity
E5D09_18175	COG3420	alginic acid biosynthetic process
E5D09_18180	COG3659	wide pore channel activity
E5D09_18185	COG4993	Dehydrogenase
E5D09_18195	COG2391	methyltransferase activity
E5D09_18210	COG1414	Transcriptional regulator
E5D09_18215	COG0583	DNA-binding transcription factor activity
E5D09_18220	COG1960	acyl-CoA dehydrogenase activity
E5D09_18245	COG2814	Major facilitator Superfamily
E5D09_18255	COG0154	amidase activity
E5D09_18275	COG4638	Rieske (2fe-2S)
E5D09_18285	COG1028	Short-chain dehydrogenase reductase Sdr
E5D09_18295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5D09_18305	COG3733	amine oxidase
E5D09_18315	COG1012	belongs to the aldehyde dehydrogenase family
E5D09_18320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E5D09_18325	COG0183	Belongs to the thiolase family
E5D09_18330	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E5D09_18335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E5D09_18345	COG4829	muconolactone delta-isomerase
E5D09_18350	COG4948	Mandelate Racemase Muconate Lactonizing
E5D09_18355	COG0583	DNA-binding transcription factor activity
E5D09_18365	COG2186	Transcriptional regulator
E5D09_18425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E5D09_18445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5D09_18460	COG1388	LysM domain
E5D09_18530	COG1063	alcohol dehydrogenase
E5D09_18555	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E5D09_18570	COG1979	alcohol dehydrogenase
E5D09_18580	COG1902	pentaerythritol trinitrate reductase activity
E5D09_18590	COG1309	transcriptional regulator
E5D09_18600	COG2130	NADP-dependent
E5D09_18645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5D09_18670	COG2194	sulfuric ester hydrolase activity
E5D09_18680	COG3316	Transposase and inactivated derivatives
E5D09_18720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5D09_18725	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5D09_18725	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5D09_18780	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5D09_18780	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5D09_18795	COG0587	DNA-directed DNA polymerase activity
E5D09_18850	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E5D09_18875	COG0194	GDP metabolic process
E5D09_18905	COG0358	DNA primase activity
E5D09_19045	COG3173	Aminoglycoside phosphotransferase
E5D09_19065	COG0482	sulfurtransferase activity
E5D09_19120	COG2184	nucleotidyltransferase activity
E5D09_19150	COG1475	DNA binding
E5D09_19155	COG1192	Involved in chromosome partitioning
E5D09_19190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5D09_19205	COG1570	exodeoxyribonuclease VII activity
E5D09_19340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs