locus-tag	class	description
AM435_00025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AM435_00070	COG0419	ATPase involved in DNA repair
AM435_00100	COG3316	Transposase and inactivated derivatives
AM435_00110	COG3316	Transposase and inactivated derivatives
AM435_00115	COG3173	Aminoglycoside phosphotransferase
AM435_00125	COG3316	Transposase and inactivated derivatives
AM435_00135	COG3316	Transposase and inactivated derivatives
AM435_00150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM435_00175	COG0756	dUTP diphosphatase activity
AM435_00420	COG1475	DNA binding
AM435_00425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM435_00535	COG0791	NLP P60 protein
AM435_00585	COG0358	DNA primase activity
AM435_00625	COG0194	GDP metabolic process
AM435_00650	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AM435_00730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM435_00765	COG0741	lytic transglycosylase activity
AM435_00795	COG2826	transposase and inactivated derivatives, IS30 family
AM435_00865	COG0484	heat shock protein binding
AM435_00970	COG3853	Toxic anion resistance protein (TelA)
AM435_00990	COG1475	DNA binding
AM435_01070	COG1525	nuclease
AM435_01140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM435_01205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM435_01210	COG2814	Major facilitator Superfamily
AM435_01225	COG0583	DNA-binding transcription factor activity
AM435_01240	COG1187	pseudouridine synthase activity
AM435_01260	COG0802	atpase or kinase
AM435_01265	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM435_01275	COG1923	regulation of RNA biosynthetic process
AM435_01280	COG0697	spore germination
AM435_01295	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM435_01310	COG0519	Catalyzes the synthesis of GMP from XMP
AM435_01310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM435_01315	COG4302	ethanolamine ammonia-lyase activity
AM435_01320	COG4303	Ethanolamine ammonia lyase large subunit
AM435_01325	COG0531	amino acid
AM435_01345	COG1454	alcohol dehydrogenase
AM435_01350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM435_01360	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AM435_01380	COG0308	aminopeptidase N
AM435_01390	COG4221	oxidoreductase activity
AM435_01400	COG1605	Chorismate mutase
AM435_01420	COG1309	transcriptional regulator
AM435_01430	COG0668	transmembrane transport
AM435_01455	COG0488	(ABC) transporter
AM435_01460	COG0589	response to stress
AM435_01475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AM435_01485	COG3135	benzoate transporter
AM435_01490	COG1522	sequence-specific DNA binding
AM435_01505	COG0583	DNA-binding transcription factor activity
AM435_01515	COG0183	Belongs to the thiolase family
AM435_01545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AM435_01555	COG0824	Thioesterase
AM435_01560	COG1454	alcohol dehydrogenase
AM435_01570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AM435_01590	COG0069	glutamate synthase activity
AM435_01895	COG2026	Addiction module toxin, RelE StbE family
AM435_01935	COG0592	DNA-directed DNA polymerase activity
AM435_02010	COG2814	Major facilitator Superfamily
AM435_02025	COG0511	ligase activity, forming carbon-carbon bonds
AM435_02045	COG1116	anion transmembrane transporter activity
AM435_02045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM435_02050	COG0745	RESPONSE REGULATOR receiver
AM435_02060	COG2146	nitrite reductase [NAD(P)H] activity
AM435_02060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM435_02065	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM435_02070	COG0243	molybdopterin cofactor binding
AM435_02080	COG0243	molybdopterin cofactor binding
AM435_02085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AM435_02100	COG0315	cyclic pyranopterin monophosphate synthase activity
AM435_02100	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM435_02105	COG0303	'Molybdopterin
AM435_02115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM435_02120	COG0697	spore germination
AM435_02140	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AM435_02145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM435_02205	COG2204	response regulator
AM435_02210	COG3852	Histidine kinase
AM435_02230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM435_02235	COG0575	Belongs to the CDS family
AM435_02270	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM435_02285	COG2137	regulation of response to DNA damage stimulus
AM435_02295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AM435_02300	COG1011	Hydrolase
AM435_02325	COG1522	sequence-specific DNA binding
AM435_02335	COG1113	amino acid transport
AM435_02350	COG0659	secondary active sulfate transmembrane transporter activity
AM435_02355	COG2135	peptidase activity
AM435_02370	COG3300	MHYT domain
AM435_02370	COG5001	Diguanylate cyclase
AM435_02390	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AM435_02390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM435_02390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM435_02395	COG1105	Belongs to the carbohydrate kinase PfkB family
AM435_02400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM435_02400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM435_02430	COG0024	Methionine aminopeptidase
AM435_02435	COG0583	DNA-binding transcription factor activity
AM435_02445	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AM435_02450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM435_02455	COG0517	IMP dehydrogenase activity
AM435_02455	COG0516	GMP reductase activity
AM435_02480	COG0552	protein localization to endoplasmic reticulum
AM435_02490	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AM435_02505	COG4890	Cyd operon protein YbgT
AM435_02510	COG1294	oxidase, subunit
AM435_02530	COG1585	Membrane protein implicated in regulation of membrane protease activity
AM435_02540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM435_02545	COG4774	siderophore transport
AM435_02560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AM435_02565	COG0569	domain protein
AM435_02570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM435_02600	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AM435_02605	COG0542	response to heat
AM435_02615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM435_02630	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM435_02630	COG1902	pentaerythritol trinitrate reductase activity
AM435_02675	COG2323	membrane
AM435_02680	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AM435_02690	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM435_02695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM435_02700	COG0183	Belongs to the thiolase family
AM435_02705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM435_02710	COG0596	Alpha beta hydrolase
AM435_02715	COG2271	Major facilitator Superfamily
AM435_02720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM435_02725	COG3485	protocatechuate 3,4-dioxygenase
AM435_02730	COG3485	protocatechuate 3,4-dioxygenase
AM435_02735	COG0710	3-dehydroquinate dehydratase activity
AM435_02740	COG3420	alginic acid biosynthetic process
AM435_02745	COG3659	wide pore channel activity
AM435_02750	COG4993	Dehydrogenase
AM435_02760	COG2391	methyltransferase activity
AM435_02775	COG1414	Transcriptional regulator
AM435_02780	COG0583	DNA-binding transcription factor activity
AM435_02785	COG1960	acyl-CoA dehydrogenase activity
AM435_02810	COG2814	Major facilitator Superfamily
AM435_02820	COG0154	amidase activity
AM435_02840	COG4638	Rieske (2fe-2S)
AM435_02850	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_02860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM435_02870	COG3733	amine oxidase
AM435_02880	COG1012	belongs to the aldehyde dehydrogenase family
AM435_02890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM435_02895	COG0183	Belongs to the thiolase family
AM435_02900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM435_02905	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM435_02915	COG4829	muconolactone delta-isomerase
AM435_02920	COG4948	Mandelate Racemase Muconate Lactonizing
AM435_02925	COG0583	DNA-binding transcription factor activity
AM435_02955	COG1012	belongs to the aldehyde dehydrogenase family
AM435_02960	COG0129	dihydroxy-acid dehydratase activity
AM435_02970	COG0583	DNA-binding transcription factor activity
AM435_02975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM435_02985	COG2084	Dehydrogenase
AM435_02990	COG2207	Transcriptional regulator
AM435_03005	COG1064	alcohol dehydrogenase
AM435_03020	COG1120	ATPase activity
AM435_03040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM435_03160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AM435_03215	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_03230	COG2207	Transcriptional regulator
AM435_03240	COG2205	protein histidine kinase activity
AM435_03245	COG0745	RESPONSE REGULATOR receiver
AM435_03250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM435_03255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM435_03260	COG1538	Outer membrane efflux protein
AM435_03270	COG2072	flavoprotein involved in K transport
AM435_03290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM435_03310	COG3539	Fimbrial protein
AM435_03335	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AM435_03345	COG0753	catalase activity
AM435_03360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM435_03425	COG3433	isochorismatase activity
AM435_03425	COG1535	isochorismatase
AM435_03430	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_03435	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AM435_03440	COG4149	molybdate abc transporter
AM435_03445	COG0725	ABC transporter, periplasmic molybdate-binding protein
AM435_03455	COG4638	Rieske (2fe-2S)
AM435_03460	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AM435_03465	COG0543	2 iron, 2 sulfur cluster binding
AM435_03465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM435_03480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM435_03490	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_03495	COG0412	Dienelactone hydrolase
AM435_03505	COG2207	Transcriptional regulator
AM435_03510	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_03515	COG2610	gluconate transmembrane transporter activity
AM435_03525	COG0583	DNA-binding transcription factor activity
AM435_03535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM435_03540	COG2031	fatty acid transporter
AM435_03545	COG0183	Belongs to the thiolase family
AM435_03550	COG0583	DNA-binding transcription factor activity
AM435_03555	COG0583	DNA-binding transcription factor activity
AM435_03570	COG1027	Aspartate ammonia-lyase
AM435_03580	COG0477	Major facilitator Superfamily
AM435_03600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM435_03605	COG4521	taurine ABC transporter
AM435_03630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AM435_03635	COG1733	regulation of RNA biosynthetic process
AM435_03640	COG2207	Transcriptional regulator
AM435_03640	COG3708	Transcriptional regulator
AM435_03655	COG0730	response to heat
AM435_03665	COG3453	Protein conserved in bacteria
AM435_03665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM435_03675	COG3781	membrane
AM435_03680	COG1063	alcohol dehydrogenase
AM435_03705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM435_03710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM435_03715	COG0022	dehydrogenase e1 component
AM435_03720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM435_03725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM435_03745	COG3706	GGDEF domain
AM435_03760	COG0133	tryptophan synthase activity
AM435_03770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM435_03805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AM435_03830	COG2226	methyltransferase
AM435_03885	COG0842	Transport permease protein
AM435_03890	COG0842	Transport permease protein
AM435_03895	COG1131	(ABC) transporter
AM435_03910	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM435_03935	COG0730	response to heat
AM435_03940	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM435_03960	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AM435_04020	COG4264	IucA IucC family
AM435_04025	COG4264	IucA IucC family
AM435_04045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM435_04060	COG1960	acyl-CoA dehydrogenase activity
AM435_04065	COG1960	acyl-CoA dehydrogenase activity
AM435_04070	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM435_04075	COG2207	Transcriptional regulator
AM435_04080	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM435_04085	COG0776	regulation of translation
AM435_04110	COG0822	iron-sulfur transferase activity
AM435_04115	COG0316	Belongs to the HesB IscA family
AM435_04145	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AM435_04165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM435_04170	COG0702	epimerase
AM435_04215	COG0339	signal peptide processing
AM435_04275	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AM435_04280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM435_04310	COG0776	regulation of translation
AM435_04330	COG0590	tRNA wobble adenosine to inosine editing
AM435_04360	COG2165	general secretion pathway protein
AM435_04375	COG0084	hydrolase, TatD family'
AM435_04395	COG1663	tetraacyldisaccharide 4'-kinase activity
AM435_04400	COG1132	(ABC) transporter
AM435_04410	COG0811	peptide transport
AM435_04415	COG1475	DNA binding
AM435_04420	COG1192	Involved in chromosome partitioning
AM435_04430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AM435_04445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM435_04450	COG0191	fructose-bisphosphate aldolase activity
AM435_04470	COG0424	maF-like protein
AM435_04475	COG2850	peptidyl-arginine hydroxylation
AM435_04485	COG0640	Transcriptional regulator
AM435_04495	COG3619	membrane
AM435_04500	COG3122	Protein conserved in bacteria
AM435_04505	COG1132	(ABC) transporter
AM435_04530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM435_04535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM435_04545	COG0506	proline dehydrogenase activity
AM435_04545	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM435_04545	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM435_04550	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AM435_04565	COG3698	Phosphodiester glycosidase
AM435_04575	COG2353	YceI-like domain
AM435_04585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM435_04630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM435_04630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM435_04655	COG3539	Fimbrial protein
AM435_04660	COG3121	Chaperone
AM435_04700	COG0697	spore germination
AM435_04710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM435_04720	COG0583	DNA-binding transcription factor activity
AM435_04745	COG1309	transcriptional regulator
AM435_04760	COG1522	sequence-specific DNA binding
AM435_04770	COG1126	abc transporter atp-binding protein
AM435_04775	COG0765	amino acid transport
AM435_04780	COG0765	amino acid transport
AM435_04810	COG1464	Belongs to the NlpA lipoprotein family
AM435_04820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM435_04825	COG2011	ABC-type metal ion transport system permease component
AM435_04830	COG0012	GTP binding
AM435_04860	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AM435_04900	COG0386	Belongs to the glutathione peroxidase family
AM435_04910	COG0436	Aminotransferase
AM435_04950	COG3634	alkyl hydroperoxide reductase activity
AM435_04965	COG0583	DNA-binding transcription factor activity
AM435_04970	COG0798	PFAM Bile acid sodium symporter
AM435_04975	COG0640	Transcriptional regulator
AM435_04990	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AM435_05000	COG0583	DNA-binding transcription factor activity
AM435_05010	COG1953	Uracil, thiamine, allantoin
AM435_05020	COG2175	clavaminate synthase activity
AM435_05025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM435_05030	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AM435_05035	COG4521	taurine ABC transporter
AM435_05055	COG0477	Major facilitator Superfamily
AM435_05080	COG1271	oxidase subunit
AM435_05085	COG1294	oxidase, subunit
AM435_05095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM435_05115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM435_05135	COG3052	prosthetic group binding
AM435_05140	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AM435_05150	COG2814	Major facilitator Superfamily
AM435_05170	COG1346	cytolysis
AM435_05180	COG0583	DNA-binding transcription factor activity
AM435_05185	COG0625	glutathione transferase activity
AM435_05190	COG0625	glutathione transferase activity
AM435_05195	COG0583	DNA-binding transcription factor activity
AM435_05210	COG1045	serine acetyltransferase
AM435_05215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM435_05220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM435_05230	COG1280	lysine exporter protein (LysE YggA)
AM435_05245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM435_05250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM435_05255	COG1126	abc transporter atp-binding protein
AM435_05260	COG0765	amino acid transport
AM435_05265	COG0765	amino acid transport
AM435_05285	COG2205	protein histidine kinase activity
AM435_05285	COG0784	Response regulator, receiver
AM435_05305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM435_05325	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_05370	COG0583	DNA-binding transcription factor activity
AM435_05390	COG0318	PFAM AMP-dependent synthetase and ligase
AM435_05395	COG1309	transcriptional regulator
AM435_05400	COG1960	acyl-CoA dehydrogenase activity
AM435_05405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM435_05410	COG1024	Enoyl-CoA hydratase
AM435_05425	COG0583	DNA-binding transcription factor activity
AM435_05440	COG1960	acyl-CoA dehydrogenase activity
AM435_05450	COG2814	Major facilitator Superfamily
AM435_05460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM435_05465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM435_05470	COG2814	Major facilitator Superfamily
AM435_05475	COG1960	acyl-CoA dehydrogenase activity
AM435_05480	COG1024	Enoyl-CoA hydratase
AM435_05485	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_05490	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM435_05495	COG0183	Belongs to the thiolase family
AM435_05505	COG2814	Major facilitator Superfamily
AM435_05515	COG1024	Enoyl-CoA hydratase
AM435_05530	COG1960	acyl-CoA dehydrogenase activity
AM435_05535	COG2814	Major facilitator Superfamily
AM435_05540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM435_05545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AM435_05560	COG3842	ATPase activity
AM435_05565	COG1840	ABC-type Fe3 transport system, periplasmic component
AM435_05575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM435_05580	COG1414	Transcriptional regulator
AM435_05590	COG0583	DNA-binding transcription factor activity
AM435_05595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM435_05600	COG1012	belongs to the aldehyde dehydrogenase family
AM435_05610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM435_05620	COG1012	belongs to the aldehyde dehydrogenase family
AM435_05625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM435_05630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM435_05635	COG2267	carboxylic ester hydrolase activity
AM435_05655	COG3038	cytochrome b561
AM435_05660	COG0753	catalase activity
AM435_05700	COG2050	protein possibly involved in aromatic compounds catabolism
AM435_05710	COG3327	negative regulation of DNA-templated transcription, initiation
AM435_05715	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AM435_05720	COG0183	Belongs to the thiolase family
AM435_05725	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM435_05730	COG1024	Enoyl-CoA hydratase
AM435_05735	COG1024	Enoyl-CoA hydratase
AM435_05740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM435_05745	COG2151	metal-sulfur cluster biosynthetic enzyme
AM435_05750	COG3396	Phenylacetate-CoA oxygenase
AM435_05755	COG3460	Phenylacetate-CoA oxygenase
AM435_05760	COG3396	Phenylacetate-CoA oxygenase
AM435_05765	COG1012	belongs to the aldehyde dehydrogenase family
AM435_05765	COG2030	dehydratase
AM435_05770	COG1760	l-serine dehydratase
AM435_05775	COG0531	amino acid
AM435_05780	COG1012	belongs to the aldehyde dehydrogenase family
AM435_05805	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM435_05815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM435_05835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM435_05855	COG0789	Transcriptional regulator
AM435_05865	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AM435_05880	COG2807	transmembrane transport
AM435_05885	COG0590	tRNA wobble adenosine to inosine editing
AM435_05895	COG0583	DNA-binding transcription factor activity
AM435_05935	COG2885	chlorophyll binding
AM435_05935	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM435_06005	COG1116	anion transmembrane transporter activity
AM435_06010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM435_06020	COG0864	Transcriptional regulator
AM435_06040	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM435_06045	COG0439	Biotin carboxylase
AM435_06060	COG1063	alcohol dehydrogenase
AM435_06070	COG1309	transcriptional regulator
AM435_06095	COG0038	chloride channel
AM435_06100	COG4770	biotin carboxylase activity
AM435_06120	COG1914	H( )-stimulated, divalent metal cation uptake system
AM435_06125	COG0583	DNA-binding transcription factor activity
AM435_06140	COG3209	COG3209 Rhs family protein
AM435_06145	COG3501	Rhs element vgr protein
AM435_06180	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM435_06200	COG2814	Major facilitator Superfamily
AM435_06210	COG1560	Kdo2-lipid A biosynthetic process
AM435_06220	COG5006	permease, DMT superfamily
AM435_06225	COG1522	sequence-specific DNA binding
AM435_06240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AM435_06285	COG1137	ATPase activity
AM435_06290	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AM435_06300	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AM435_06305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AM435_06305	COG0517	IMP dehydrogenase activity
AM435_06340	COG1733	regulation of RNA biosynthetic process
AM435_06345	COG2814	Major facilitator Superfamily
AM435_06395	COG1278	Cold shock
AM435_06400	COG1280	lysine exporter protein (LysE YggA)
AM435_06435	COG1570	exodeoxyribonuclease VII activity
AM435_06490	COG0583	DNA-binding transcription factor activity
AM435_06495	COG4638	Rieske (2fe-2S)
AM435_06500	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AM435_06505	COG0633	Ferredoxin
AM435_06505	COG0543	2 iron, 2 sulfur cluster binding
AM435_06510	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_06515	COG3135	benzoate transporter
AM435_06520	COG2814	Major facilitator Superfamily
AM435_06535	COG1643	Atp-dependent helicase
AM435_06540	COG0450	alkyl hydroperoxide reductase
AM435_06550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AM435_06560	COG3634	alkyl hydroperoxide reductase activity
AM435_06580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AM435_06585	COG0625	glutathione transferase activity
AM435_06595	COG2885	chlorophyll binding
AM435_06645	COG1765	OsmC-like protein
AM435_06655	COG0667	Aldo Keto reductase
AM435_06670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AM435_06680	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM435_06700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AM435_06710	COG3038	cytochrome b561
AM435_06715	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AM435_06720	COG2252	PERMEase
AM435_06735	COG3316	Transposase and inactivated derivatives
AM435_06740	COG1660	Displays ATPase and GTPase activities
AM435_06745	COG2746	aminoglycoside 3-N-acetyltransferase activity
AM435_06780	COG3316	Transposase and inactivated derivatives
AM435_06800	COG3316	Transposase and inactivated derivatives
AM435_06810	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AM435_06815	COG0583	DNA-binding transcription factor activity
AM435_06825	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AM435_06875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM435_06890	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM435_06905	COG2814	Major facilitator Superfamily
AM435_06910	COG1024	Enoyl-CoA hydratase
AM435_06915	COG1012	belongs to the aldehyde dehydrogenase family
AM435_06925	COG1960	acyl-CoA dehydrogenase activity
AM435_06950	COG2186	Transcriptional regulator
AM435_06955	COG1012	belongs to the aldehyde dehydrogenase family
AM435_06965	COG4948	Mandelate Racemase Muconate Lactonizing
AM435_06970	COG2271	Major facilitator Superfamily
AM435_06975	COG2721	sulfolactate sulfo-lyase activity
AM435_06980	COG0697	spore germination
AM435_06995	COG1113	amino acid transport
AM435_07005	COG1113	amino acid transport
AM435_07025	COG1012	belongs to the aldehyde dehydrogenase family
AM435_07045	COG0531	amino acid
AM435_07080	COG3209	COG3209 Rhs family protein
AM435_07085	COG3501	Rhs element vgr protein
AM435_07105	COG4269	membrane
AM435_07120	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM435_07120	COG1902	pentaerythritol trinitrate reductase activity
AM435_07130	COG3706	GGDEF domain
AM435_07130	COG4251	negative regulation of phosphorylation
AM435_07130	COG5001	Diguanylate cyclase
AM435_07130	COG2203	Gaf domain
AM435_07140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM435_07160	COG4172	Belongs to the ABC transporter superfamily
AM435_07165	COG4239	(ABC) transporter, permease
AM435_07170	COG4174	ABC transporter (Permease)
AM435_07180	COG0741	lytic transglycosylase activity
AM435_07180	COG1388	LysM domain
AM435_07180	COG0741	lytic transglycosylase activity
AM435_07180	COG1388	LysM domain
AM435_07185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM435_07225	COG0583	DNA-binding transcription factor activity
AM435_07230	COG1279	arginine transmembrane transporter activity
AM435_07250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM435_07255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM435_07260	COG0006	proline dipeptidase activity
AM435_07295	COG2194	sulfuric ester hydrolase activity
AM435_07345	COG0739	heme binding
AM435_07670	COG0512	Glutamine amidotransferase of anthranilate synthase
AM435_07675	COG0308	aminopeptidase N
AM435_07705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM435_07740	COG3739	integral membrane protein
AM435_07755	COG1169	isochorismate synthase
AM435_07765	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AM435_07775	COG1132	(ABC) transporter
AM435_07790	COG1535	isochorismatase
AM435_07790	COG3433	isochorismatase activity
AM435_07795	COG1021	2,3-dihydroxybenzoate-AMP ligase
AM435_07800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM435_07810	COG4774	siderophore transport
AM435_07815	COG4607	ABC-type enterochelin transport system periplasmic component
AM435_07820	COG4604	ABC transporter, ATP-binding protein
AM435_07825	COG4605	iron ion homeostasis
AM435_07830	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM435_07835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM435_07850	COG2964	Protein conserved in bacteria
AM435_07860	COG1741	Belongs to the pirin family
AM435_07880	COG1309	transcriptional regulator
AM435_07890	COG4948	Mandelate Racemase Muconate Lactonizing
AM435_07895	COG2814	Major facilitator Superfamily
AM435_07930	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AM435_07930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM435_07935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM435_07950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM435_07965	COG0583	DNA-binding transcription factor activity
AM435_07970	COG1113	amino acid transport
AM435_07990	COG2508	Transcriptional regulator
AM435_07990	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AM435_08030	COG2879	small protein
AM435_08035	COG1966	Carbon starvation protein
AM435_08080	COG1067	ATP-dependent peptidase activity
AM435_08085	COG0583	DNA-binding transcription factor activity
AM435_08110	COG1686	Belongs to the peptidase S11 family
AM435_08115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM435_08150	COG0616	signal peptide processing
AM435_08155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AM435_08165	COG0573	inorganic phosphate transmembrane transporter activity
AM435_08170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM435_08175	COG1113	amino acid transport
AM435_08180	COG3961	Belongs to the TPP enzyme family
AM435_08185	COG1522	sequence-specific DNA binding
AM435_08195	COG0076	glutamate decarboxylase activity
AM435_08200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM435_08210	COG1309	transcriptional regulator
AM435_08225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM435_08260	COG0352	thiamine-phosphate diphosphorylase activity
AM435_08285	COG0612	Peptidase, M16
AM435_08300	COG0583	DNA-binding transcription factor activity
AM435_08305	COG0477	Major facilitator Superfamily
AM435_08330	COG1187	pseudouridine synthase activity
AM435_08345	COG1686	Belongs to the peptidase S11 family
AM435_08350	COG1252	NADH dehydrogenase
AM435_08360	COG0415	Belongs to the DNA photolyase family
AM435_08375	COG1215	transferase activity, transferring glycosyl groups
AM435_08405	COG2070	2-Nitropropane dioxygenase
AM435_08460	COG0556	nucleotide-excision repair
AM435_08530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AM435_08535	COG1381	Involved in DNA repair and RecF pathway recombination
AM435_08545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AM435_08560	COG0681	Belongs to the peptidase S26 family
AM435_08575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM435_08595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AM435_08600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM435_08605	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AM435_08615	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AM435_08620	COG4208	sulfate ABC transporter
AM435_08625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AM435_08630	COG0583	DNA-binding transcription factor activity
AM435_08635	COG4625	pathogenesis
AM435_08650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AM435_08665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM435_08675	COG1051	belongs to the nudix hydrolase family
AM435_08675	COG1056	cytidyltransferase-related domain
AM435_08680	COG1024	Enoyl-CoA hydratase
AM435_08685	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AM435_08690	COG2814	Major facilitator Superfamily
AM435_08695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM435_08695	COG0047	phosphoribosylformylglycinamidine synthase activity
AM435_08715	COG1473	amidohydrolase
AM435_08720	COG0824	Thioesterase
AM435_08740	COG0823	Involved in the tonB-independent uptake of proteins
AM435_08760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM435_08805	COG0628	permease
AM435_08815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM435_08820	COG0596	Alpha beta hydrolase
AM435_08825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM435_08825	COG0616	signal peptide processing
AM435_08835	COG2333	competence protein COMEC
AM435_08835	COG0658	competence protein
AM435_08840	COG1136	(ABC) transporter
AM435_08845	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM435_08875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM435_08895	COG0463	Glycosyl transferase, family 2
AM435_08925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AM435_08930	COG1280	lysine exporter protein (LysE YggA)
AM435_08940	COG0019	diaminopimelate decarboxylase activity
AM435_08950	COG1113	amino acid transport
AM435_08965	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AM435_08975	COG3339	Conserved Protein
AM435_08980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AM435_08985	COG0243	molybdopterin cofactor binding
AM435_08990	COG1929	Belongs to the glycerate kinase type-1 family
AM435_09005	COG0778	Nitroreductase
AM435_09030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM435_09045	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM435_09070	COG0741	lytic transglycosylase activity
AM435_09090	COG0584	glycerophosphoryl diester phosphodiesterase
AM435_09095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM435_09120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM435_09140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM435_09145	COG0477	Major facilitator Superfamily
AM435_09195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AM435_09200	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM435_09225	COG0505	Belongs to the CarA family
AM435_09245	COG0589	response to stress
AM435_09260	COG2843	Capsule synthesis protein
AM435_09280	COG2321	neutral zinc metallopeptidase
AM435_09285	COG2354	Protein conserved in bacteria
AM435_09305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM435_09330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM435_09335	COG1053	succinate dehydrogenase
AM435_09340	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AM435_09345	COG2009	succinate dehydrogenase
AM435_09385	COG2921	Belongs to the UPF0250 family
AM435_09390	COG0321	lipoyl(octanoyl) transferase activity
AM435_09405	COG0531	amino acid
AM435_09415	COG1733	regulation of RNA biosynthetic process
AM435_09420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AM435_09425	COG1648	precorrin-2 dehydrogenase activity
AM435_09425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AM435_09440	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AM435_09470	COG0671	phosphoesterase, PA-phosphatase related
AM435_09475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM435_09485	COG1538	Outer membrane efflux protein
AM435_09490	COG0393	Putative heavy-metal-binding
AM435_09495	COG0393	Putative heavy-metal-binding
AM435_09505	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_09515	COG0525	valine-tRNA ligase activity
AM435_09535	COG0583	DNA-binding transcription factor activity
AM435_09545	COG0004	ammonium transporteR
AM435_09555	COG0642	Histidine kinase
AM435_09560	COG0745	RESPONSE REGULATOR receiver
AM435_09565	COG2194	sulfuric ester hydrolase activity
AM435_09585	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM435_09600	COG2315	Protein conserved in bacteria
AM435_09605	COG0142	geranyltranstransferase activity
AM435_09610	COG2828	Protein conserved in bacteria
AM435_09615	COG1113	amino acid transport
AM435_09625	COG0582	viral genome integration into host DNA
AM435_09835	COG5410	chromosome segregation
AM435_10030	COG2207	Transcriptional regulator
AM435_10055	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM435_10075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM435_10085	COG1530	ribonuclease E activity
AM435_10090	COG0424	maF-like protein
AM435_10095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AM435_10100	COG1792	Involved in formation and maintenance of cell shape
AM435_10105	COG1077	Cell shape determining protein MreB Mrl
AM435_10110	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM435_10120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM435_10150	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AM435_10155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM435_10160	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM435_10165	COG1115	amino acid carrier protein
AM435_10185	COG2814	Major facilitator Superfamily
AM435_10190	COG1289	transmembrane transporter activity
AM435_10240	COG1376	ErfK ybiS ycfS ynhG family protein
AM435_10245	COG2832	Protein of unknown function (DUF454)
AM435_10255	COG5510	response to toxic substance
AM435_10275	COG0840	transmembrane signaling receptor activity
AM435_10315	COG3422	double-strand break repair
AM435_10320	COG2824	Alkylphosphonate utilization operon protein PhnA
AM435_10325	COG3189	MarR family transcriptional regulator
AM435_10335	COG0354	folic acid binding
AM435_10340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM435_10350	COG0679	Auxin Efflux Carrier
AM435_10355	COG1902	pentaerythritol trinitrate reductase activity
AM435_10360	COG4772	TonB-dependent receptor
AM435_10365	COG2094	Belongs to the DNA glycosylase MPG family
AM435_10395	COG2233	PERMEase
AM435_10405	COG0833	amino acid
AM435_10410	COG1690	Belongs to the RtcB family
AM435_10420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM435_10420	COG2885	chlorophyll binding
AM435_10430	COG0183	Belongs to the thiolase family
AM435_10450	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM435_10470	COG2207	Transcriptional regulator
AM435_10475	COG0183	Belongs to the thiolase family
AM435_10505	COG1272	protein, Hemolysin III
AM435_10510	COG0477	Major facilitator Superfamily
AM435_10525	COG0450	alkyl hydroperoxide reductase
AM435_10545	COG0285	dihydrofolate synthase activity
AM435_10580	COG0133	tryptophan synthase activity
AM435_10595	COG2096	Adenosyltransferase
AM435_10615	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AM435_10620	COG0745	RESPONSE REGULATOR receiver
AM435_10625	COG2205	protein histidine kinase activity
AM435_10635	COG1960	acyl-CoA dehydrogenase activity
AM435_10640	COG1960	acyl-CoA dehydrogenase activity
AM435_10645	COG0583	DNA-binding transcription factor activity
AM435_10650	COG0625	glutathione transferase activity
AM435_10735	COG0438	transferase activity, transferring glycosyl groups
AM435_10740	COG0463	Glycosyl transferase, family 2
AM435_10745	COG0726	polysaccharide deacetylase
AM435_10765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AM435_10770	COG2205	protein histidine kinase activity
AM435_10815	COG1862	Preprotein translocase
AM435_10825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM435_10830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AM435_10840	COG3781	membrane
AM435_10845	COG0613	PHP domain protein
AM435_10855	COG2350	Protein conserved in bacteria
AM435_10885	COG1607	acyl-coa hydrolase
AM435_10900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM435_10900	COG3453	Protein conserved in bacteria
AM435_10965	COG1408	metallophosphoesterase
AM435_10970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM435_11000	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AM435_11005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM435_11020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AM435_11030	COG2969	positive regulation of protein catabolic process
AM435_11050	COG1960	acyl-CoA dehydrogenase activity
AM435_11055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM435_11070	COG1309	transcriptional regulator
AM435_11075	COG1960	acyl-CoA dehydrogenase activity
AM435_11120	COG1183	phosphatidylcholine synthase activity
AM435_11125	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AM435_11155	COG0741	lytic transglycosylase activity
AM435_11155	COG1196	nuclear chromosome segregation
AM435_11155	COG0739	heme binding
AM435_11165	COG1702	phosphate starvation-inducible protein PhoH
AM435_11200	COG1295	ribonuclease BN
AM435_11205	COG0697	spore germination
AM435_11210	COG2169	Transcriptional regulator
AM435_11215	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM435_11260	COG0557	exoribonuclease II activity
AM435_11265	COG0339	signal peptide processing
AM435_11270	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AM435_11300	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AM435_11305	COG1960	acyl-CoA dehydrogenase activity
AM435_11330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AM435_11340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AM435_11460	COG0626	cystathionine gamma-synthase activity
AM435_11465	COG0433	COG0433 Predicted ATPase
AM435_11470	COG1017	nitric oxide dioxygenase activity
AM435_11470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM435_11475	COG1959	2 iron, 2 sulfur cluster binding
AM435_11490	COG1301	dicarboxylic acid transport
AM435_11495	COG1946	Acyl-CoA thioesterase
AM435_11515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM435_11520	COG1040	competence protein
AM435_11525	COG0494	nUDIX hydrolase
AM435_11535	COG0598	Magnesium transport protein CorA
AM435_11545	COG2854	intermembrane phospholipid transfer
AM435_11555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM435_11560	COG1127	ABC transporter
AM435_11570	COG0513	Belongs to the DEAD box helicase family
AM435_11590	COG0408	coproporphyrinogen oxidase activity
AM435_11605	COG1960	acyl-CoA dehydrogenase activity
AM435_11615	COG1983	PspC domain protein
AM435_11620	COG0517	IMP dehydrogenase activity
AM435_11665	COG0583	DNA-binding transcription factor activity
AM435_11705	COG1012	belongs to the aldehyde dehydrogenase family
AM435_11715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM435_11720	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM435_11725	COG0833	amino acid
AM435_11755	COG1192	Involved in chromosome partitioning
AM435_11760	COG0628	permease
AM435_11770	COG1289	transmembrane transporter activity
AM435_11785	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM435_11790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AM435_11800	COG0277	FAD linked oxidase domain protein
AM435_11805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM435_11830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AM435_11835	COG5380	lipid catabolic process
AM435_11855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AM435_11905	COG0194	GDP metabolic process
AM435_11920	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM435_11945	COG3307	-O-antigen
AM435_11965	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AM435_11970	COG1704	LemA family
AM435_11980	COG0493	'glutamate synthase
AM435_11985	COG0070	glutamate synthase
AM435_11985	COG0067	glutamate synthase
AM435_11985	COG0069	glutamate synthase activity
AM435_12035	COG2226	methyltransferase
AM435_12050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM435_12055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM435_12100	COG0833	amino acid
AM435_12160	COG0488	(ABC) transporter
AM435_12170	COG4221	oxidoreductase activity
AM435_12175	COG0659	secondary active sulfate transmembrane transporter activity
AM435_12185	COG0745	RESPONSE REGULATOR receiver
AM435_12200	COG0427	acetyl-CoA hydrolase
AM435_12230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AM435_12270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM435_12325	COG2207	Transcriptional regulator
AM435_12330	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AM435_12345	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM435_12355	COG1733	regulation of RNA biosynthetic process
AM435_12370	COG1733	regulation of RNA biosynthetic process
AM435_12400	COG0667	Aldo Keto reductase
AM435_12425	COG0583	DNA-binding transcription factor activity
AM435_12430	COG2814	Major facilitator Superfamily
AM435_12460	COG1335	isochorismatase
AM435_12470	COG1012	belongs to the aldehyde dehydrogenase family
AM435_12475	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM435_12485	COG1113	amino acid transport
AM435_12495	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AM435_12510	COG2814	Major facilitator Superfamily
AM435_12520	COG0352	thiamine-phosphate diphosphorylase activity
AM435_12520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM435_12520	COG0351	phosphomethylpyrimidine kinase
AM435_12540	COG1309	transcriptional regulator
AM435_12545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AM435_12560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM435_12570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM435_12575	COG3162	membrane
AM435_12580	COG0784	Response regulator, receiver
AM435_12580	COG2198	Histidine kinase
AM435_12580	COG2205	protein histidine kinase activity
AM435_12605	COG1522	sequence-specific DNA binding
AM435_12610	COG1335	isochorismatase
AM435_12615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM435_12625	COG0668	transmembrane transport
AM435_12630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM435_12635	COG1519	Transferase
AM435_12640	COG1902	pentaerythritol trinitrate reductase activity
AM435_12660	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM435_12685	COG0426	domain, Protein
AM435_12685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM435_12690	COG4774	siderophore transport
AM435_12695	COG2119	membrane
AM435_12705	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM435_12715	COG4942	peptidase
AM435_12730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AM435_12740	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AM435_12760	COG0189	ligase activity
AM435_12790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM435_12830	COG0708	Exodeoxyribonuclease III
AM435_12835	COG1393	Belongs to the ArsC family
AM435_12890	COG2233	PERMEase
AM435_12900	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM435_12910	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AM435_12920	COG3150	esterase
AM435_12945	COG3179	chitinase
AM435_12950	COG3501	Rhs element vgr protein
AM435_12960	COG2918	glutathione biosynthetic process
AM435_12975	COG2733	membrane
AM435_12980	COG0436	Aminotransferase
AM435_12985	COG0534	Mate efflux family protein
AM435_13045	COG0753	catalase activity
AM435_13095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AM435_13100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AM435_13110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM435_13115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AM435_13120	COG0546	phosphoglycolate phosphatase activity
AM435_13130	COG0010	Belongs to the arginase family
AM435_13160	COG2188	Transcriptional regulator
AM435_13170	COG0523	cobalamin synthesis protein
AM435_13180	COG1113	amino acid transport
AM435_13190	COG0625	glutathione transferase activity
AM435_13210	COG1683	Conserved Protein
AM435_13215	COG0534	Mate efflux family protein
AM435_13220	COG0385	Bile acid
AM435_13225	COG1335	isochorismatase
AM435_13230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM435_13255	COG2116	formate transmembrane transporter activity
AM435_13260	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AM435_13265	COG2133	pyrroloquinoline quinone binding
AM435_13270	COG2983	Belongs to the UPF0260 family
AM435_13290	COG1194	a g-specific adenine glycosylase
AM435_13305	COG2818	Glycosylase
AM435_13310	COG1064	alcohol dehydrogenase
AM435_13315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM435_13330	COG0583	DNA-binding transcription factor activity
AM435_13335	COG0656	L-ascorbic acid biosynthetic process
AM435_13340	COG2814	Major facilitator Superfamily
AM435_13375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM435_13390	COG2233	PERMEase
AM435_13430	COG0733	neurotransmitter:sodium symporter activity
AM435_13475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AM435_13480	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AM435_13485	COG0596	Alpha beta hydrolase
AM435_13510	COG0488	(ABC) transporter
AM435_13515	COG0586	Pfam SNARE associated Golgi protein
AM435_13525	COG0187	DNA topoisomerase II activity
AM435_13535	COG0592	DNA-directed DNA polymerase activity
AM435_13545	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AM435_13560	COG0706	membrane insertase activity
AM435_13575	COG1230	cation diffusion facilitator family transporter
AM435_13580	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM435_13595	COG0402	S-adenosylhomocysteine deaminase activity
AM435_13605	COG0754	glutathionylspermidine amidase activity
AM435_13620	COG0861	Integral membrane protein TerC family
AM435_13625	COG0671	phosphoesterase, PA-phosphatase related
AM435_13635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM435_13655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM435_13660	COG2951	lytic endotransglycosylase activity
AM435_13715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM435_13755	COG1047	Peptidyl-prolyl cis-trans
AM435_13765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AM435_13770	COG0196	riboflavin kinase activity
AM435_13780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AM435_13785	COG1309	transcriptional regulator
AM435_13790	COG1116	anion transmembrane transporter activity
AM435_13795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM435_13800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM435_13805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM435_13810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM435_13830	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_13835	COG0546	phosphoglycolate phosphatase activity
AM435_13895	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM435_13900	COG0728	peptidoglycan biosynthetic process
AM435_13925	COG1596	polysaccharide export
AM435_13930	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AM435_13970	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AM435_13985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AM435_13990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM435_13995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AM435_14010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM435_14015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM435_14025	COG2186	Transcriptional regulator
AM435_14035	COG0277	FAD linked oxidase domain protein
AM435_14040	COG1448	Aminotransferase
AM435_14050	COG1802	Transcriptional regulator
AM435_14065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM435_14085	COG1051	belongs to the nudix hydrolase family
AM435_14115	COG0564	pseudouridine synthase activity
AM435_14140	COG1522	sequence-specific DNA binding
AM435_14155	COG0251	oxidation-reduction process
AM435_14160	COG1113	amino acid transport
AM435_14165	COG1113	amino acid transport
AM435_14185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM435_14190	COG1960	acyl-CoA dehydrogenase activity
AM435_14195	COG1024	Enoyl-CoA hydratase
AM435_14200	COG1024	Enoyl-CoA hydratase
AM435_14205	COG0477	Major facilitator Superfamily
AM435_14210	COG3916	Acyl-homoserine-lactone synthase
AM435_14220	COG2197	response regulator
AM435_14235	COG1960	acyl-CoA dehydrogenase activity
AM435_14240	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AM435_14240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM435_14240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM435_14240	COG3321	synthase
AM435_14260	COG2267	carboxylic ester hydrolase activity
AM435_14280	COG0271	Belongs to the BolA IbaG family
AM435_14290	COG1192	Involved in chromosome partitioning
AM435_14305	COG0586	Pfam SNARE associated Golgi protein
AM435_14310	COG2259	Doxx family
AM435_14315	COG4399	Belongs to the UPF0754 family
AM435_14320	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM435_14320	COG0519	Catalyzes the synthesis of GMP from XMP
AM435_14365	COG0281	malic enzyme
AM435_14375	COG2837	iron assimilation
AM435_14380	COG1280	lysine exporter protein (LysE YggA)
AM435_14385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM435_14390	COG1121	(ABC) transporter
AM435_14455	COG0386	Belongs to the glutathione peroxidase family
AM435_14470	COG1309	transcriptional regulator
AM435_14475	COG0697	spore germination
AM435_14485	COG0758	DNA mediated transformation
AM435_14520	COG1309	transcriptional regulator
AM435_14555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AM435_14565	COG0655	NAD(P)H dehydrogenase (quinone) activity
AM435_14600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM435_14610	COG2814	Major facilitator Superfamily
AM435_14620	COG1253	flavin adenine dinucleotide binding
AM435_14630	COG2860	membrane
AM435_14635	COG0477	Major facilitator Superfamily
AM435_14645	COG0318	PFAM AMP-dependent synthetase and ligase
AM435_14660	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM435_14675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM435_14685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM435_14690	COG0606	chelatase, subunit chli
AM435_14720	COG0589	response to stress
AM435_14725	COG0659	secondary active sulfate transmembrane transporter activity
AM435_14795	COG0606	chelatase, subunit chli
AM435_14805	COG0347	Belongs to the P(II) protein family
AM435_14810	COG0004	ammonium transporteR
AM435_14820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM435_14820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM435_14860	COG0795	lipopolysaccharide-transporting ATPase activity
AM435_14865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AM435_14870	COG0793	Belongs to the peptidase S41A family
AM435_14885	COG2197	response regulator
AM435_14895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AM435_14905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM435_14910	COG4974	Belongs to the 'phage' integrase family
AM435_14935	COG0772	Belongs to the SEDS family
AM435_14940	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM435_14945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM435_14950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM435_14975	COG0697	spore germination
AM435_14980	COG1538	Outer membrane efflux protein
AM435_15000	COG3275	phosphorelay sensor kinase activity
AM435_15010	COG0181	hydroxymethylbilane synthase activity
AM435_15055	COG1716	ATPase activity
AM435_15060	COG0546	phosphoglycolate phosphatase activity
AM435_15155	COG0596	Alpha beta hydrolase
AM435_15160	COG2056	Na+-H+ antiporter family
AM435_15175	COG0326	Molecular chaperone. Has ATPase activity
AM435_15190	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AM435_15250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM435_15300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM435_15305	COG2169	Transcriptional regulator
AM435_15305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM435_15335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AM435_15345	COG0497	DNA recombination
AM435_15360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM435_15370	COG0237	dephospho-CoA kinase activity
AM435_15420	COG0195	Participates in both transcription termination and antitermination
AM435_15440	COG2212	antiporter activity
AM435_15450	COG0651	ATP synthesis coupled electron transport
AM435_15455	COG1006	Multisubunit Na H antiporter MnhC subunit
AM435_15460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM435_15460	COG2111	Na H antiporter
AM435_15475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AM435_15480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM435_15495	COG2226	methyltransferase
AM435_15515	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AM435_15520	COG1074	ATP-dependent DNA helicase activity
AM435_15525	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM435_15545	COG0598	Magnesium transport protein CorA
AM435_15550	COG0789	Transcriptional regulator
AM435_15555	COG0484	heat shock protein binding
AM435_15565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AM435_15570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM435_15570	COG0475	glutathione-regulated potassium exporter activity
AM435_15575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AM435_15595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM435_15605	COG4535	Mg2 and Co2 transporter CorC
AM435_15610	COG0425	Belongs to the sulfur carrier protein TusA family
AM435_15615	COG0644	oxidoreductase
AM435_15615	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AM435_15625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AM435_15640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM435_15645	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AM435_15685	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM435_15700	COG0534	Mate efflux family protein
AM435_15710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM435_15715	COG4221	oxidoreductase activity
AM435_15720	COG0583	DNA-binding transcription factor activity
AM435_15740	COG1530	ribonuclease E activity
AM435_15755	COG0546	phosphoglycolate phosphatase activity
AM435_15760	COG2378	regulation of single-species biofilm formation
AM435_15765	COG0625	glutathione transferase activity
AM435_15775	COG0583	DNA-binding transcription factor activity
AM435_15840	COG0473	3-isopropylmalate dehydrogenase activity
AM435_15900	COG1301	dicarboxylic acid transport
AM435_15910	COG1560	Kdo2-lipid A biosynthetic process
AM435_15915	COG1280	lysine exporter protein (LysE YggA)
AM435_15935	COG1733	regulation of RNA biosynthetic process
AM435_15960	COG0210	DNA helicase
AM435_15965	COG0724	RNA recognition motif
AM435_15985	COG4651	solute:proton antiporter activity
AM435_15985	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM435_15990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AM435_15995	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AM435_16010	COG0788	formyltetrahydrofolate deformylase activity
AM435_16110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM435_16110	COG2813	Specifically methylates the guanine in position
AM435_16120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM435_16130	COG4774	siderophore transport
AM435_16140	COG0740	serine-type endopeptidase activity
AM435_16160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AM435_16160	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AM435_16165	COG0857	belongs to the CobB CobQ family
AM435_16165	COG0280	phosphate acetyltransferase
AM435_16170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AM435_16180	COG0800	Aldolase
AM435_16190	COG3265	gluconokinase activity
AM435_16195	COG1012	belongs to the aldehyde dehydrogenase family
AM435_16205	COG2267	carboxylic ester hydrolase activity
AM435_16220	COG0793	Belongs to the peptidase S41A family
AM435_16255	COG1426	Protein conserved in bacteria
AM435_16295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM435_16300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM435_16310	COG0318	PFAM AMP-dependent synthetase and ligase
AM435_16325	COG2986	histidine ammonia-lyase
AM435_16365	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_16370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AM435_16390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM435_16400	COG1162	GTPase activity
AM435_16405	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AM435_16420	COG1538	Outer membrane efflux protein
AM435_16425	COG1136	(ABC) transporter
AM435_16425	COG0577	efflux transmembrane transporter activity
AM435_16465	COG0028	Belongs to the TPP enzyme family
AM435_16470	COG0440	acetolactate synthase activity
AM435_16505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AM435_16520	COG0084	hydrolase, TatD family'
AM435_16535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AM435_16545	COG0583	DNA-binding transcription factor activity
AM435_16555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM435_16560	COG2814	Major facilitator Superfamily
AM435_16570	COG0697	spore germination
AM435_16575	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM435_16580	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM435_16585	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AM435_16600	COG3622	Belongs to the hyi family
AM435_16605	COG2084	Dehydrogenase
AM435_16610	COG1024	Enoyl-CoA hydratase
AM435_16615	COG5002	protein histidine kinase activity
AM435_16615	COG2205	protein histidine kinase activity
AM435_16615	COG0784	Response regulator, receiver
AM435_16635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM435_16645	COG3956	TIGRFAM MazG family protein
AM435_16650	COG1555	photosystem II stabilization
AM435_16655	COG0617	tRNA 3'-terminal CCA addition
AM435_16660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AM435_16680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM435_16685	COG3028	Belongs to the UPF0307 family
AM435_16690	COG0318	PFAM AMP-dependent synthetase and ligase
AM435_16710	COG0625	glutathione transferase activity
AM435_16715	COG1238	metal cluster binding
AM435_16730	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AM435_16755	COG0072	phenylalanine-tRNA ligase activity
AM435_16785	COG0248	Ppx GppA phosphatase
AM435_16795	COG0037	tRNA processing
AM435_16835	COG1764	response to oxidative stress
AM435_16840	COG1846	Transcriptional regulator
AM435_16850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM435_16910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AM435_16915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AM435_16920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AM435_16930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AM435_16975	COG1214	PFAM Peptidase M22, glycoprotease
AM435_17000	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM435_17005	COG0561	phosphatase activity
AM435_17015	COG2132	Multicopper oxidase
AM435_17020	COG3667	copper resistance
AM435_17035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM435_17040	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AM435_17045	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AM435_17075	COG1063	alcohol dehydrogenase
AM435_17080	COG0583	DNA-binding transcription factor activity
AM435_17085	COG1960	acyl-CoA dehydrogenase activity
AM435_17090	COG2814	Major facilitator Superfamily
AM435_17095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM435_17105	COG1053	succinate dehydrogenase
AM435_17110	COG0583	DNA-binding transcription factor activity
AM435_17130	COG0583	DNA-binding transcription factor activity
AM435_17140	COG1473	amidohydrolase
AM435_17160	COG0583	DNA-binding transcription factor activity
AM435_17170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM435_17175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM435_17205	COG0384	phenazine biosynthesis protein PhzF
AM435_17225	COG4993	Dehydrogenase
AM435_17295	COG2826	transposase and inactivated derivatives, IS30 family
AM435_17305	COG2826	transposase and inactivated derivatives, IS30 family
AM435_17315	COG2205	protein histidine kinase activity
AM435_17325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM435_17345	COG0745	RESPONSE REGULATOR receiver
AM435_17350	COG2205	protein histidine kinase activity
AM435_17385	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AM435_17415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM435_17420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM435_17440	COG0583	DNA-binding transcription factor activity
AM435_17460	COG0668	transmembrane transport
AM435_17470	COG2081	HI0933 family
AM435_17475	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AM435_17505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM435_17505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM435_17515	COG0489	protein tyrosine kinase activity
AM435_17575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM435_17585	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM435_17600	COG0730	response to heat
AM435_17610	COG1196	nuclear chromosome segregation
AM435_17630	COG2223	nitrite transmembrane transporter activity
AM435_17635	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AM435_17655	COG2226	methyltransferase
AM435_17655	COG0596	Alpha beta hydrolase
AM435_17655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM435_17670	COG4106	trans-aconitate 2-methyltransferase activity
AM435_17685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AM435_17690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AM435_17695	COG0009	L-threonylcarbamoyladenylate synthase
AM435_17700	COG3101	peptidyl-lysine hydroxylation
AM435_17705	COG1399	metal-binding, possibly nucleic acid-binding protein
AM435_17730	COG1652	LysM domain
AM435_17735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM435_17735	COG0352	thiamine-phosphate diphosphorylase activity
AM435_17735	COG0351	phosphomethylpyrimidine kinase
AM435_17745	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AM435_17775	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM435_17805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AM435_17820	COG0358	DNA primase activity
AM435_17830	COG0564	pseudouridine synthase activity
AM435_17855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM435_17875	COG0583	DNA-binding transcription factor activity
AM435_17880	COG0473	3-isopropylmalate dehydrogenase activity
AM435_17900	COG1012	belongs to the aldehyde dehydrogenase family
AM435_17920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AM435_17920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM435_17980	COG0456	acetyltransferase
AM435_17990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AM435_18000	COG0492	ferredoxin-NADP+ reductase activity
AM435_18005	COG1674	ftsk spoiiie
AM435_18005	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM435_18010	COG1280	lysine exporter protein (LysE YggA)
AM435_18030	COG2894	cell division
AM435_18045	COG0204	Acyl-transferase
AM435_18050	COG2885	chlorophyll binding
AM435_18055	COG0210	DNA helicase
AM435_18065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM435_18080	COG0121	glutamine amidotransferase
AM435_18105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM435_18110	COG0735	belongs to the Fur family
AM435_18135	COG0420	3'-5' exonuclease activity
AM435_18155	COG1090	epimerase
AM435_18170	COG2050	protein possibly involved in aromatic compounds catabolism
AM435_18180	COG2814	Major facilitator Superfamily
AM435_18185	COG0405	Gamma-glutamyltransferase
AM435_18335	COG5410	chromosome segregation
AM435_18455	COG1598	PFAM Uncharacterised protein family UPF0150
AM435_18470	COG0741	lytic transglycosylase activity
AM435_18470	COG0739	heme binding
AM435_18470	COG1196	nuclear chromosome segregation
AM435_18535	COG0477	Major facilitator Superfamily
AM435_18540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM435_18550	COG1595	DNA-templated transcription, initiation
AM435_18605	COG0531	amino acid
AM435_18610	COG2040	homocysteine
AM435_18635	COG1309	transcriptional regulator
AM435_18640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM435_18645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM435_18655	COG1607	acyl-coa hydrolase
AM435_18665	COG0523	cobalamin synthesis protein
AM435_18675	COG4681	YaeQ
AM435_18685	COG0726	polysaccharide deacetylase
AM435_18685	COG1649	PFAM Uncharacterised BCR, COG1649
AM435_18690	COG1215	transferase activity, transferring glycosyl groups
AM435_18700	COG1024	Enoyl-CoA hydratase
AM435_18715	COG1414	Transcriptional regulator
AM435_18735	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_18745	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM435_18750	COG2271	Major facilitator Superfamily
AM435_18760	COG2267	carboxylic ester hydrolase activity
AM435_18765	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_18780	COG0028	Belongs to the TPP enzyme family
AM435_18790	COG0477	Major facilitator Superfamily
AM435_18795	COG0242	peptide deformylase activity
AM435_18800	COG2066	Belongs to the glutaminase family
AM435_18805	COG2207	Transcriptional regulator
AM435_18810	COG2223	nitrite transmembrane transporter activity
AM435_18830	COG0583	DNA-binding transcription factor activity
AM435_18835	COG1028	Short-chain dehydrogenase reductase Sdr
AM435_18840	COG2271	Major facilitator Superfamily
AM435_18845	COG3959	Transketolase, thiamine diphosphate binding domain
AM435_18850	COG3958	Transketolase
AM435_18860	COG0306	phosphate transporter
AM435_18880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM435_18925	COG4181	ATPase activity
AM435_18930	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AM435_18955	COG0583	DNA-binding transcription factor activity
AM435_18965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM435_18970	COG1773	rubredoxin
AM435_19065	COG0804	urea catabolic process
AM435_19075	COG0830	nickel cation binding
AM435_19090	COG0742	ribosomal rna small subunit methyltransferase
AM435_19095	COG0768	penicillin binding
AM435_19120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AM435_19125	COG2878	Part of a membrane complex involved in electron transport
AM435_19130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM435_19140	COG3384	dioxygenase
AM435_19165	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM435_19545	COG3104	oligopeptide transport
AM435_19560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AM435_19595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM435_19600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AM435_19605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM435_19625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM435_19630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AM435_19635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AM435_19650	COG1960	acyl-CoA dehydrogenase activity
AM435_19655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM435_19660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM435_19670	COG2223	nitrite transmembrane transporter activity
AM435_19680	COG0024	Methionine aminopeptidase
AM435_19685	COG0052	Belongs to the universal ribosomal protein uS2 family
AM435_19700	COG2207	Transcriptional regulator
AM435_19725	COG2951	lytic endotransglycosylase activity
AM435_19730	COG0772	Belongs to the SEDS family
AM435_19745	COG0842	Transport permease protein
AM435_19750	COG1131	(ABC) transporter
AM435_19785	COG1538	Outer membrane efflux protein
AM435_19795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM435_19810	COG4215	(ABC) transporter
AM435_19815	COG4160	amino acid transport
AM435_19820	COG4598	ABC transporter
AM435_19830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM435_19840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM435_19855	COG1720	tRNA m6t6A37 methyltransferase activity
AM435_19875	COG0745	RESPONSE REGULATOR receiver
AM435_19880	COG0642	Histidine kinase
AM435_19890	COG0494	nUDIX hydrolase
AM435_19900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM435_19905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM435_19910	COG3139	Protein of unknown function (DUF1315)
AM435_19915	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM435_19925	COG1301	dicarboxylic acid transport
AM435_19930	COG1960	acyl-CoA dehydrogenase activity
AM435_19935	COG2819	hydrolase of the alpha beta superfamily
AM435_19945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AM435_19955	COG2195	Cleaves the N-terminal amino acid of tripeptides
AM435_19960	COG1234	tRNA 3'-trailer cleavage
AM435_19990	COG2363	Small membrane protein
AM435_20010	COG0513	Belongs to the DEAD box helicase family
AM435_20020	COG0778	Nitroreductase
AM435_20050	COG1286	toxin biosynthetic process
AM435_20075	COG4783	chaperone-mediated protein folding
AM435_20080	COG1610	YqeY-like protein
AM435_20085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AM435_20180	COG3111	PFAM Bacterial OB fold (BOF) protein
AM435_20205	COG3243	poly(R)-hydroxyalkanoic acid synthase
AM435_20210	COG0786	glutamate:sodium symporter activity
AM435_20220	COG2186	Transcriptional regulator
AM435_20275	COG0477	Major facilitator Superfamily
AM435_20305	COG2985	domain, Protein
AM435_20320	COG2995	paraquat-inducible protein a
AM435_20325	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AM435_20325	COG3008	intermembrane lipid transfer
AM435_20345	COG1794	racemase activity, acting on amino acids and derivatives
AM435_20375	COG1301	dicarboxylic acid transport
AM435_20390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM435_20395	COG2011	ABC-type metal ion transport system permease component
AM435_20400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM435_20405	COG1464	Belongs to the NlpA lipoprotein family
AM435_20410	COG0151	Belongs to the GarS family
AM435_20415	COG0138	bifunctional purine biosynthesis protein purh
AM435_20420	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AM435_20450	COG2308	Evidence 4 Homologs of previously reported genes of
AM435_20460	COG1305	Transglutaminase-like
AM435_20470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM435_20475	COG0305	Participates in initiation and elongation during chromosome replication
AM435_20500	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AM435_20510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM435_20515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM435_20550	COG1649	PFAM Uncharacterised BCR, COG1649
AM435_20550	COG0726	polysaccharide deacetylase
AM435_20555	COG1215	transferase activity, transferring glycosyl groups
AM435_20560	COG3658	cytochrome
AM435_20570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM435_20590	COG0583	DNA-binding transcription factor activity
AM435_20610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM435_20615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM435_20630	COG1960	acyl-CoA dehydrogenase activity
AM435_20635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM435_20640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM435_20665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AM435_20670	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AM435_20680	COG2205	protein histidine kinase activity
AM435_20685	COG0745	RESPONSE REGULATOR receiver
AM435_20690	COG0174	glutamine synthetase
AM435_20710	COG0729	surface antigen