locus-tag	class	description
AM442_00015	COG3781	membrane
AM442_00020	COG0613	PHP domain protein
AM442_00030	COG2350	Protein conserved in bacteria
AM442_00060	COG1607	acyl-coa hydrolase
AM442_00075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM442_00075	COG3453	Protein conserved in bacteria
AM442_00120	COG2199	diguanylate cyclase activity
AM442_00130	COG1408	metallophosphoesterase
AM442_00135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM442_00145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AM442_00165	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AM442_00170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM442_00185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AM442_00195	COG2969	positive regulation of protein catabolic process
AM442_00215	COG1960	acyl-CoA dehydrogenase activity
AM442_00220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM442_00235	COG1309	transcriptional regulator
AM442_00240	COG1960	acyl-CoA dehydrogenase activity
AM442_00290	COG1183	phosphatidylcholine synthase activity
AM442_00295	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AM442_00325	COG1196	nuclear chromosome segregation
AM442_00325	COG0741	lytic transglycosylase activity
AM442_00325	COG0739	heme binding
AM442_00335	COG1702	phosphate starvation-inducible protein PhoH
AM442_00370	COG1295	ribonuclease BN
AM442_00375	COG0697	spore germination
AM442_00385	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM442_00430	COG0557	exoribonuclease II activity
AM442_00435	COG0339	signal peptide processing
AM442_00440	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AM442_00470	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AM442_00475	COG1960	acyl-CoA dehydrogenase activity
AM442_00500	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AM442_00510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AM442_00630	COG0626	cystathionine gamma-synthase activity
AM442_00635	COG0433	COG0433 Predicted ATPase
AM442_00645	COG1017	nitric oxide dioxygenase activity
AM442_00645	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM442_00650	COG1959	2 iron, 2 sulfur cluster binding
AM442_00665	COG1301	dicarboxylic acid transport
AM442_00670	COG1946	Acyl-CoA thioesterase
AM442_00690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM442_00695	COG1040	competence protein
AM442_00700	COG0494	nUDIX hydrolase
AM442_00710	COG0598	Magnesium transport protein CorA
AM442_00720	COG2854	intermembrane phospholipid transfer
AM442_00730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM442_00735	COG1127	ABC transporter
AM442_00740	COG0513	Belongs to the DEAD box helicase family
AM442_00760	COG0408	coproporphyrinogen oxidase activity
AM442_00775	COG1960	acyl-CoA dehydrogenase activity
AM442_00785	COG1983	PspC domain protein
AM442_00790	COG0517	IMP dehydrogenase activity
AM442_00825	COG1106	Psort location Cytoplasmic, score
AM442_00855	COG0583	DNA-binding transcription factor activity
AM442_00895	COG1012	belongs to the aldehyde dehydrogenase family
AM442_00905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM442_00910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM442_00915	COG0833	amino acid
AM442_00945	COG1192	Involved in chromosome partitioning
AM442_00950	COG0628	permease
AM442_00960	COG1289	transmembrane transporter activity
AM442_00975	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM442_00980	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AM442_01005	COG0277	FAD linked oxidase domain protein
AM442_01010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM442_01035	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AM442_01040	COG5380	lipid catabolic process
AM442_01060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AM442_01110	COG0194	GDP metabolic process
AM442_01125	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM442_01145	COG3307	-O-antigen
AM442_01160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AM442_01165	COG1704	LemA family
AM442_01175	COG0493	'glutamate synthase
AM442_01180	COG0067	glutamate synthase
AM442_01180	COG0070	glutamate synthase
AM442_01180	COG0069	glutamate synthase activity
AM442_01230	COG2226	methyltransferase
AM442_01245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM442_01250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM442_01295	COG0833	amino acid
AM442_01380	COG0488	(ABC) transporter
AM442_01390	COG4221	oxidoreductase activity
AM442_01395	COG0659	secondary active sulfate transmembrane transporter activity
AM442_01410	COG0745	RESPONSE REGULATOR receiver
AM442_01425	COG0427	acetyl-CoA hydrolase
AM442_01455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AM442_01485	COG2329	Antibiotic biosynthesis monooxygenase
AM442_01500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM442_01570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM442_01585	COG3316	Transposase and inactivated derivatives
AM442_01595	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM442_01605	COG1733	regulation of RNA biosynthetic process
AM442_01640	COG0667	Aldo Keto reductase
AM442_01660	COG0583	DNA-binding transcription factor activity
AM442_01665	COG2814	Major facilitator Superfamily
AM442_01675	COG1113	amino acid transport
AM442_01695	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AM442_01695	COG2508	Transcriptional regulator
AM442_01735	COG1335	isochorismatase
AM442_01745	COG1012	belongs to the aldehyde dehydrogenase family
AM442_01750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM442_01760	COG1113	amino acid transport
AM442_01770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AM442_01785	COG2814	Major facilitator Superfamily
AM442_01795	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM442_01795	COG0352	thiamine-phosphate diphosphorylase activity
AM442_01795	COG0351	phosphomethylpyrimidine kinase
AM442_01815	COG1309	transcriptional regulator
AM442_01820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AM442_01825	COG3706	GGDEF domain
AM442_01835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM442_01845	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM442_01850	COG3162	membrane
AM442_01855	COG0784	Response regulator, receiver
AM442_01855	COG2198	Histidine kinase
AM442_01855	COG2205	protein histidine kinase activity
AM442_01880	COG1522	sequence-specific DNA binding
AM442_01885	COG1335	isochorismatase
AM442_01890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM442_01900	COG0668	transmembrane transport
AM442_01905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM442_01910	COG1519	Transferase
AM442_01915	COG1902	pentaerythritol trinitrate reductase activity
AM442_01950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM442_01975	COG0426	domain, Protein
AM442_01975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM442_01980	COG4774	siderophore transport
AM442_01985	COG2119	membrane
AM442_01995	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM442_02005	COG4942	peptidase
AM442_02020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AM442_02030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AM442_02050	COG0189	ligase activity
AM442_02100	COG0708	Exodeoxyribonuclease III
AM442_02105	COG1393	Belongs to the ArsC family
AM442_02120	COG3706	GGDEF domain
AM442_02165	COG2351	hydroxyisourate hydrolase activity
AM442_02170	COG2233	PERMEase
AM442_02180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM442_02190	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AM442_02200	COG3150	esterase
AM442_02250	COG3501	Rhs element vgr protein
AM442_02260	COG2918	glutathione biosynthetic process
AM442_02275	COG2733	membrane
AM442_02280	COG0436	Aminotransferase
AM442_02285	COG0534	Mate efflux family protein
AM442_02375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AM442_02380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AM442_02390	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM442_02395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AM442_02410	COG0010	Belongs to the arginase family
AM442_02465	COG0523	cobalamin synthesis protein
AM442_02475	COG1113	amino acid transport
AM442_02485	COG0625	glutathione transferase activity
AM442_02505	COG1683	Conserved Protein
AM442_02510	COG0534	Mate efflux family protein
AM442_02515	COG0385	Bile acid
AM442_02520	COG1335	isochorismatase
AM442_02525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM442_02545	COG2116	formate transmembrane transporter activity
AM442_02550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AM442_02555	COG2133	pyrroloquinoline quinone binding
AM442_02560	COG2983	Belongs to the UPF0260 family
AM442_02580	COG1194	a g-specific adenine glycosylase
AM442_02595	COG2818	Glycosylase
AM442_02600	COG1064	alcohol dehydrogenase
AM442_02605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM442_02620	COG0583	DNA-binding transcription factor activity
AM442_02625	COG0656	L-ascorbic acid biosynthetic process
AM442_02630	COG2814	Major facilitator Superfamily
AM442_02665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM442_02680	COG2233	PERMEase
AM442_02685	COG0583	DNA-binding transcription factor activity
AM442_02720	COG0733	neurotransmitter:sodium symporter activity
AM442_02765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AM442_02770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AM442_02775	COG0596	Alpha beta hydrolase
AM442_02800	COG0488	(ABC) transporter
AM442_02805	COG0586	Pfam SNARE associated Golgi protein
AM442_02815	COG0187	DNA topoisomerase II activity
AM442_02825	COG0592	DNA-directed DNA polymerase activity
AM442_02835	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AM442_02850	COG0706	membrane insertase activity
AM442_02865	COG1230	cation diffusion facilitator family transporter
AM442_02885	COG0402	S-adenosylhomocysteine deaminase activity
AM442_02895	COG0754	glutathionylspermidine amidase activity
AM442_02905	COG0861	Integral membrane protein TerC family
AM442_02910	COG0671	phosphoesterase, PA-phosphatase related
AM442_02920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM442_02940	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM442_02945	COG2951	lytic endotransglycosylase activity
AM442_03000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM442_03040	COG1047	Peptidyl-prolyl cis-trans
AM442_03050	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AM442_03055	COG0196	riboflavin kinase activity
AM442_03065	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AM442_03070	COG1309	transcriptional regulator
AM442_03075	COG1116	anion transmembrane transporter activity
AM442_03080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM442_03085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM442_03090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM442_03095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM442_03115	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_03120	COG0546	phosphoglycolate phosphatase activity
AM442_03180	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM442_03185	COG0728	peptidoglycan biosynthetic process
AM442_03215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AM442_03275	COG1216	Glycosyl transferase, family 2
AM442_03280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM442_03285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AM442_03300	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM442_03330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM442_03340	COG2186	Transcriptional regulator
AM442_03350	COG0277	FAD linked oxidase domain protein
AM442_03355	COG1448	Aminotransferase
AM442_03365	COG1802	Transcriptional regulator
AM442_03380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM442_03400	COG1051	belongs to the nudix hydrolase family
AM442_03445	COG0564	pseudouridine synthase activity
AM442_03470	COG1522	sequence-specific DNA binding
AM442_03485	COG0251	oxidation-reduction process
AM442_03490	COG1113	amino acid transport
AM442_03495	COG1113	amino acid transport
AM442_03515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM442_03520	COG1960	acyl-CoA dehydrogenase activity
AM442_03525	COG1024	Enoyl-CoA hydratase
AM442_03530	COG1024	Enoyl-CoA hydratase
AM442_03535	COG0477	Major facilitator Superfamily
AM442_03540	COG3916	Acyl-homoserine-lactone synthase
AM442_03550	COG2197	response regulator
AM442_03565	COG1960	acyl-CoA dehydrogenase activity
AM442_03570	COG4221	oxidoreductase activity
AM442_03570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM442_03570	COG0300	oxidoreductase activity
AM442_03570	COG3321	synthase
AM442_03610	COG0271	Belongs to the BolA IbaG family
AM442_03620	COG1192	Involved in chromosome partitioning
AM442_03635	COG0586	Pfam SNARE associated Golgi protein
AM442_03640	COG2259	Doxx family
AM442_03645	COG4399	Belongs to the UPF0754 family
AM442_03650	COG0519	Catalyzes the synthesis of GMP from XMP
AM442_03650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM442_03695	COG0281	malic enzyme
AM442_03700	COG2837	iron assimilation
AM442_03705	COG1280	lysine exporter protein (LysE YggA)
AM442_03710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM442_03715	COG1121	(ABC) transporter
AM442_03780	COG0386	Belongs to the glutathione peroxidase family
AM442_03795	COG1309	transcriptional regulator
AM442_03800	COG0697	spore germination
AM442_03810	COG0758	DNA mediated transformation
AM442_03845	COG1309	transcriptional regulator
AM442_03880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AM442_03890	COG0655	NAD(P)H dehydrogenase (quinone) activity
AM442_03925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM442_03935	COG2814	Major facilitator Superfamily
AM442_03945	COG1253	flavin adenine dinucleotide binding
AM442_03950	COG3012	SEC-C Motif Domain Protein
AM442_03955	COG2860	membrane
AM442_03960	COG0477	Major facilitator Superfamily
AM442_03970	COG0318	PFAM AMP-dependent synthetase and ligase
AM442_03985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM442_04000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM442_04010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM442_04015	COG0606	chelatase, subunit chli
AM442_04065	COG2205	protein histidine kinase activity
AM442_04080	COG2132	Multicopper oxidase
AM442_04090	COG0789	Transcriptional regulator
AM442_04125	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM442_04150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AM442_04185	COG0606	chelatase, subunit chli
AM442_04195	COG0347	Belongs to the P(II) protein family
AM442_04200	COG0004	ammonium transporteR
AM442_04210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM442_04210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM442_04250	COG0795	lipopolysaccharide-transporting ATPase activity
AM442_04255	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AM442_04260	COG0793	Belongs to the peptidase S41A family
AM442_04275	COG2197	response regulator
AM442_04285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AM442_04295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM442_04300	COG4974	Belongs to the 'phage' integrase family
AM442_04325	COG0772	Belongs to the SEDS family
AM442_04330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM442_04335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM442_04340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM442_04365	COG0697	spore germination
AM442_04370	COG1538	Outer membrane efflux protein
AM442_04390	COG3275	phosphorelay sensor kinase activity
AM442_04400	COG0181	hydroxymethylbilane synthase activity
AM442_04445	COG1716	ATPase activity
AM442_04450	COG0546	phosphoglycolate phosphatase activity
AM442_04545	COG0596	Alpha beta hydrolase
AM442_04550	COG2056	Na+-H+ antiporter family
AM442_04565	COG0326	Molecular chaperone. Has ATPase activity
AM442_04580	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AM442_04650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM442_04655	COG2169	Transcriptional regulator
AM442_04655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM442_04685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AM442_04695	COG0497	DNA recombination
AM442_04710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM442_04720	COG0237	dephospho-CoA kinase activity
AM442_04770	COG0195	Participates in both transcription termination and antitermination
AM442_04790	COG2212	antiporter activity
AM442_04800	COG0651	ATP synthesis coupled electron transport
AM442_04805	COG1006	Multisubunit Na H antiporter MnhC subunit
AM442_04810	COG2111	Na H antiporter
AM442_04810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM442_04825	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AM442_04835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM442_04845	COG2226	methyltransferase
AM442_04865	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AM442_04870	COG1074	ATP-dependent DNA helicase activity
AM442_04875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM442_04895	COG0598	Magnesium transport protein CorA
AM442_04900	COG0789	Transcriptional regulator
AM442_04905	COG0484	heat shock protein binding
AM442_04920	COG0475	glutathione-regulated potassium exporter activity
AM442_04920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM442_04925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AM442_04950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM442_04960	COG4535	Mg2 and Co2 transporter CorC
AM442_04965	COG0425	Belongs to the sulfur carrier protein TusA family
AM442_04970	COG0644	oxidoreductase
AM442_04970	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AM442_04980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AM442_04995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM442_05000	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AM442_05040	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM442_05055	COG0534	Mate efflux family protein
AM442_05065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM442_05070	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_05075	COG0583	DNA-binding transcription factor activity
AM442_05095	COG1530	ribonuclease E activity
AM442_05110	COG0546	phosphoglycolate phosphatase activity
AM442_05115	COG2378	regulation of single-species biofilm formation
AM442_05120	COG0625	glutathione transferase activity
AM442_05130	COG0583	DNA-binding transcription factor activity
AM442_05195	COG0473	3-isopropylmalate dehydrogenase activity
AM442_05250	COG1301	dicarboxylic acid transport
AM442_05260	COG1560	Kdo2-lipid A biosynthetic process
AM442_05265	COG1280	lysine exporter protein (LysE YggA)
AM442_05285	COG1733	regulation of RNA biosynthetic process
AM442_05310	COG0210	DNA helicase
AM442_05315	COG0724	RNA recognition motif
AM442_05335	COG4651	solute:proton antiporter activity
AM442_05335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM442_05340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AM442_05345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AM442_05360	COG0788	formyltetrahydrofolate deformylase activity
AM442_05460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM442_05460	COG2813	Specifically methylates the guanine in position
AM442_05470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM442_05480	COG4774	siderophore transport
AM442_05490	COG0740	serine-type endopeptidase activity
AM442_05510	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AM442_05510	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AM442_05515	COG0857	belongs to the CobB CobQ family
AM442_05515	COG0280	phosphate acetyltransferase
AM442_05520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AM442_05580	COG0384	phenazine biosynthesis protein PhzF
AM442_05605	COG0800	Aldolase
AM442_05615	COG3265	gluconokinase activity
AM442_05620	COG1012	belongs to the aldehyde dehydrogenase family
AM442_05630	COG2267	carboxylic ester hydrolase activity
AM442_05645	COG0793	Belongs to the peptidase S41A family
AM442_05680	COG1426	Protein conserved in bacteria
AM442_05720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM442_05730	COG1162	GTPase activity
AM442_05735	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AM442_05750	COG1538	Outer membrane efflux protein
AM442_05755	COG1136	(ABC) transporter
AM442_05755	COG0577	efflux transmembrane transporter activity
AM442_05760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM442_05790	COG0028	Belongs to the TPP enzyme family
AM442_05795	COG0440	acetolactate synthase activity
AM442_05835	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AM442_05850	COG0084	hydrolase, TatD family'
AM442_05865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AM442_05875	COG0583	DNA-binding transcription factor activity
AM442_05885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM442_05890	COG2814	Major facilitator Superfamily
AM442_05900	COG0697	spore germination
AM442_05905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM442_05910	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM442_05915	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AM442_05930	COG3622	Belongs to the hyi family
AM442_05935	COG2084	Dehydrogenase
AM442_05940	COG1024	Enoyl-CoA hydratase
AM442_05945	COG5002	protein histidine kinase activity
AM442_05945	COG2205	protein histidine kinase activity
AM442_05945	COG0784	Response regulator, receiver
AM442_05965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM442_05975	COG3956	TIGRFAM MazG family protein
AM442_05980	COG1555	photosystem II stabilization
AM442_05985	COG0617	tRNA 3'-terminal CCA addition
AM442_05990	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AM442_06010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM442_06015	COG3028	Belongs to the UPF0307 family
AM442_06020	COG0318	PFAM AMP-dependent synthetase and ligase
AM442_06040	COG0625	glutathione transferase activity
AM442_06045	COG1238	metal cluster binding
AM442_06060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AM442_06080	COG0072	phenylalanine-tRNA ligase activity
AM442_06110	COG0248	Ppx GppA phosphatase
AM442_06120	COG0037	tRNA processing
AM442_06160	COG1764	response to oxidative stress
AM442_06165	COG1846	Transcriptional regulator
AM442_06175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM442_06235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AM442_06240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AM442_06245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AM442_06305	COG1214	PFAM Peptidase M22, glycoprotease
AM442_06320	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AM442_06330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM442_06335	COG0561	phosphatase activity
AM442_06345	COG2132	Multicopper oxidase
AM442_06365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM442_06370	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AM442_06375	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AM442_06405	COG1063	alcohol dehydrogenase
AM442_06410	COG0583	DNA-binding transcription factor activity
AM442_06415	COG1960	acyl-CoA dehydrogenase activity
AM442_06420	COG2814	Major facilitator Superfamily
AM442_06425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM442_06435	COG1053	succinate dehydrogenase
AM442_06440	COG0583	DNA-binding transcription factor activity
AM442_06460	COG0583	DNA-binding transcription factor activity
AM442_06485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM442_06490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM442_06590	COG0384	phenazine biosynthesis protein PhzF
AM442_06605	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM442_06625	COG0745	RESPONSE REGULATOR receiver
AM442_06630	COG2205	protein histidine kinase activity
AM442_06665	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AM442_06695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM442_06700	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM442_06720	COG0583	DNA-binding transcription factor activity
AM442_06740	COG0668	transmembrane transport
AM442_06750	COG2081	HI0933 family
AM442_06755	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AM442_06785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM442_06785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM442_06795	COG0489	protein tyrosine kinase activity
AM442_06865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM442_06875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM442_06890	COG0730	response to heat
AM442_06900	COG1196	nuclear chromosome segregation
AM442_06920	COG2223	nitrite transmembrane transporter activity
AM442_06925	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AM442_06930	COG1877	trehalose-phosphatase activity
AM442_06935	COG0596	Alpha beta hydrolase
AM442_06935	COG2226	methyltransferase
AM442_06935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM442_06950	COG4106	trans-aconitate 2-methyltransferase activity
AM442_06965	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AM442_06970	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AM442_06975	COG0009	L-threonylcarbamoyladenylate synthase
AM442_06980	COG3101	peptidyl-lysine hydroxylation
AM442_06985	COG1399	metal-binding, possibly nucleic acid-binding protein
AM442_07010	COG1652	LysM domain
AM442_07015	COG0351	phosphomethylpyrimidine kinase
AM442_07015	COG0352	thiamine-phosphate diphosphorylase activity
AM442_07015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM442_07025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AM442_07055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM442_07080	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AM442_07095	COG0358	DNA primase activity
AM442_07105	COG0564	pseudouridine synthase activity
AM442_07300	COG5410	chromosome segregation
AM442_07460	COG0582	viral genome integration into host DNA
AM442_07470	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM442_07490	COG0583	DNA-binding transcription factor activity
AM442_07495	COG0473	3-isopropylmalate dehydrogenase activity
AM442_07515	COG1012	belongs to the aldehyde dehydrogenase family
AM442_07535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM442_07535	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AM442_07595	COG0456	acetyltransferase
AM442_07605	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AM442_07610	COG0492	ferredoxin-NADP+ reductase activity
AM442_07615	COG1674	ftsk spoiiie
AM442_07620	COG1280	lysine exporter protein (LysE YggA)
AM442_07635	COG2894	cell division
AM442_07650	COG0204	Acyl-transferase
AM442_07655	COG2885	chlorophyll binding
AM442_07660	COG0210	DNA helicase
AM442_07670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM442_07685	COG0121	glutamine amidotransferase
AM442_07710	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM442_07715	COG0735	belongs to the Fur family
AM442_07740	COG0420	3'-5' exonuclease activity
AM442_07760	COG1090	epimerase
AM442_07775	COG2050	protein possibly involved in aromatic compounds catabolism
AM442_07785	COG2814	Major facilitator Superfamily
AM442_07790	COG0405	Gamma-glutamyltransferase
AM442_07845	COG0477	Major facilitator Superfamily
AM442_07850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM442_07860	COG1595	DNA-templated transcription, initiation
AM442_07915	COG0531	amino acid
AM442_07950	COG1309	transcriptional regulator
AM442_07955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM442_07960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM442_07970	COG1607	acyl-coa hydrolase
AM442_07980	COG0523	cobalamin synthesis protein
AM442_07990	COG4681	YaeQ
AM442_08000	COG0726	polysaccharide deacetylase
AM442_08000	COG1649	PFAM Uncharacterised BCR, COG1649
AM442_08005	COG1215	transferase activity, transferring glycosyl groups
AM442_08015	COG1024	Enoyl-CoA hydratase
AM442_08030	COG1414	Transcriptional regulator
AM442_08050	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_08065	COG2271	Major facilitator Superfamily
AM442_08075	COG2267	carboxylic ester hydrolase activity
AM442_08080	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_08090	COG1012	belongs to the aldehyde dehydrogenase family
AM442_08095	COG0028	Belongs to the TPP enzyme family
AM442_08105	COG0477	Major facilitator Superfamily
AM442_08110	COG0242	peptide deformylase activity
AM442_08115	COG2066	Belongs to the glutaminase family
AM442_08120	COG2207	Transcriptional regulator
AM442_08125	COG2223	nitrite transmembrane transporter activity
AM442_08145	COG0583	DNA-binding transcription factor activity
AM442_08150	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_08155	COG2271	Major facilitator Superfamily
AM442_08160	COG3959	Transketolase, thiamine diphosphate binding domain
AM442_08165	COG3958	Transketolase
AM442_08175	COG0306	phosphate transporter
AM442_08195	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM442_08240	COG4181	ATPase activity
AM442_08275	COG0583	DNA-binding transcription factor activity
AM442_08285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM442_08290	COG1773	rubredoxin
AM442_08340	COG2851	Citrate transporter
AM442_08350	COG1253	flavin adenine dinucleotide binding
AM442_08400	COG0804	urea catabolic process
AM442_08410	COG0830	nickel cation binding
AM442_08425	COG0742	ribosomal rna small subunit methyltransferase
AM442_08430	COG0768	penicillin binding
AM442_08455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AM442_08460	COG2878	Part of a membrane complex involved in electron transport
AM442_08465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM442_08480	COG3384	dioxygenase
AM442_08510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM442_08550	COG0006	proline dipeptidase activity
AM442_08555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM442_08560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM442_08580	COG1279	arginine transmembrane transporter activity
AM442_08585	COG0583	DNA-binding transcription factor activity
AM442_08625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM442_08630	COG0741	lytic transglycosylase activity
AM442_08630	COG1388	LysM domain
AM442_08630	COG0741	lytic transglycosylase activity
AM442_08630	COG1388	LysM domain
AM442_08640	COG4174	ABC transporter (Permease)
AM442_08645	COG4239	(ABC) transporter, permease
AM442_08650	COG4172	Belongs to the ABC transporter superfamily
AM442_08670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM442_08680	COG4251	negative regulation of phosphorylation
AM442_08680	COG5001	Diguanylate cyclase
AM442_08680	COG3706	GGDEF domain
AM442_08680	COG2203	Gaf domain
AM442_08690	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM442_08690	COG1902	pentaerythritol trinitrate reductase activity
AM442_08745	COG3501	Rhs element vgr protein
AM442_08750	COG3209	COG3209 Rhs family protein
AM442_08790	COG1113	amino acid transport
AM442_08800	COG0531	amino acid
AM442_08820	COG1012	belongs to the aldehyde dehydrogenase family
AM442_08840	COG1113	amino acid transport
AM442_08860	COG0697	spore germination
AM442_08865	COG2721	sulfolactate sulfo-lyase activity
AM442_08870	COG2271	Major facilitator Superfamily
AM442_08875	COG4948	Mandelate Racemase Muconate Lactonizing
AM442_08885	COG1012	belongs to the aldehyde dehydrogenase family
AM442_08890	COG2186	Transcriptional regulator
AM442_08900	COG3316	Transposase and inactivated derivatives
AM442_08925	COG1960	acyl-CoA dehydrogenase activity
AM442_08935	COG1012	belongs to the aldehyde dehydrogenase family
AM442_08940	COG1024	Enoyl-CoA hydratase
AM442_08945	COG2814	Major facilitator Superfamily
AM442_08960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM442_08975	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM442_09020	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AM442_09025	COG2072	flavoprotein involved in K transport
AM442_09030	COG0300	oxidoreductase activity
AM442_09045	COG1309	transcriptional regulator
AM442_09050	COG1741	Belongs to the pirin family
AM442_09065	COG2072	flavoprotein involved in K transport
AM442_09075	COG2252	PERMEase
AM442_09080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AM442_09085	COG3038	cytochrome b561
AM442_09095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AM442_09115	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM442_09125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AM442_09140	COG0667	Aldo Keto reductase
AM442_09150	COG1765	OsmC-like protein
AM442_09200	COG2885	chlorophyll binding
AM442_09210	COG0625	glutathione transferase activity
AM442_09215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AM442_09235	COG3634	alkyl hydroperoxide reductase activity
AM442_09245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AM442_09255	COG0450	alkyl hydroperoxide reductase
AM442_09260	COG1643	Atp-dependent helicase
AM442_09275	COG2814	Major facilitator Superfamily
AM442_09280	COG3135	benzoate transporter
AM442_09285	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_09290	COG0633	Ferredoxin
AM442_09290	COG0543	2 iron, 2 sulfur cluster binding
AM442_09295	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AM442_09300	COG4638	Rieske (2fe-2S)
AM442_09305	COG0583	DNA-binding transcription factor activity
AM442_09315	COG2871	sodium ion transport
AM442_09400	COG1570	exodeoxyribonuclease VII activity
AM442_09435	COG1280	lysine exporter protein (LysE YggA)
AM442_09440	COG1278	Cold shock
AM442_09480	COG2814	Major facilitator Superfamily
AM442_09485	COG1733	regulation of RNA biosynthetic process
AM442_09535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AM442_09545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AM442_09550	COG1137	ATPase activity
AM442_09555	COG1538	Outer membrane efflux protein
AM442_09595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AM442_09610	COG1522	sequence-specific DNA binding
AM442_09615	COG5006	permease, DMT superfamily
AM442_09625	COG1560	Kdo2-lipid A biosynthetic process
AM442_09640	COG2814	Major facilitator Superfamily
AM442_09670	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AM442_09695	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM442_09725	COG3501	Rhs element vgr protein
AM442_09730	COG3209	COG3209 Rhs family protein
AM442_09765	COG0583	DNA-binding transcription factor activity
AM442_09770	COG1914	H( )-stimulated, divalent metal cation uptake system
AM442_09790	COG4770	biotin carboxylase activity
AM442_09795	COG0038	chloride channel
AM442_09820	COG1063	alcohol dehydrogenase
AM442_09835	COG0439	Biotin carboxylase
AM442_09840	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM442_09845	COG1733	regulation of RNA biosynthetic process
AM442_09855	COG0864	Transcriptional regulator
AM442_09865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM442_09870	COG1116	anion transmembrane transporter activity
AM442_09940	COG2885	chlorophyll binding
AM442_09940	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM442_09980	COG0583	DNA-binding transcription factor activity
AM442_09990	COG0590	tRNA wobble adenosine to inosine editing
AM442_09995	COG2807	transmembrane transport
AM442_10010	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AM442_10025	COG0789	Transcriptional regulator
AM442_10040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM442_10060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM442_10085	COG1012	belongs to the aldehyde dehydrogenase family
AM442_10090	COG0531	amino acid
AM442_10095	COG1760	l-serine dehydratase
AM442_10100	COG1012	belongs to the aldehyde dehydrogenase family
AM442_10100	COG2030	dehydratase
AM442_10105	COG3396	Phenylacetate-CoA oxygenase
AM442_10110	COG3460	Phenylacetate-CoA oxygenase
AM442_10115	COG3396	Phenylacetate-CoA oxygenase
AM442_10120	COG2151	metal-sulfur cluster biosynthetic enzyme
AM442_10125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM442_10130	COG1024	Enoyl-CoA hydratase
AM442_10135	COG1024	Enoyl-CoA hydratase
AM442_10140	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM442_10145	COG0183	Belongs to the thiolase family
AM442_10150	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AM442_10155	COG3327	negative regulation of DNA-templated transcription, initiation
AM442_10165	COG2050	protein possibly involved in aromatic compounds catabolism
AM442_10195	COG0753	catalase activity
AM442_10200	COG3038	cytochrome b561
AM442_10220	COG2267	carboxylic ester hydrolase activity
AM442_10225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM442_10230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM442_10235	COG1012	belongs to the aldehyde dehydrogenase family
AM442_10245	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM442_10255	COG1012	belongs to the aldehyde dehydrogenase family
AM442_10260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM442_10265	COG0583	DNA-binding transcription factor activity
AM442_10275	COG1414	Transcriptional regulator
AM442_10280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM442_10290	COG1840	ABC-type Fe3 transport system, periplasmic component
AM442_10295	COG3842	ATPase activity
AM442_10310	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AM442_10315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM442_10320	COG2814	Major facilitator Superfamily
AM442_10325	COG1960	acyl-CoA dehydrogenase activity
AM442_10350	COG1024	Enoyl-CoA hydratase
AM442_10365	COG2192	nodulation
AM442_10370	COG1280	lysine exporter protein (LysE YggA)
AM442_10385	COG0183	Belongs to the thiolase family
AM442_10390	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM442_10395	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_10400	COG1024	Enoyl-CoA hydratase
AM442_10405	COG1960	acyl-CoA dehydrogenase activity
AM442_10410	COG2814	Major facilitator Superfamily
AM442_10415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM442_10420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM442_10430	COG2814	Major facilitator Superfamily
AM442_10440	COG1960	acyl-CoA dehydrogenase activity
AM442_10455	COG0583	DNA-binding transcription factor activity
AM442_10470	COG1024	Enoyl-CoA hydratase
AM442_10475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM442_10480	COG1960	acyl-CoA dehydrogenase activity
AM442_10485	COG1309	transcriptional regulator
AM442_10490	COG0318	PFAM AMP-dependent synthetase and ligase
AM442_10510	COG0583	DNA-binding transcription factor activity
AM442_10560	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_10580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM442_10600	COG2205	protein histidine kinase activity
AM442_10600	COG0784	Response regulator, receiver
AM442_10620	COG0765	amino acid transport
AM442_10625	COG0765	amino acid transport
AM442_10630	COG1126	abc transporter atp-binding protein
AM442_10635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM442_10640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM442_10655	COG1280	lysine exporter protein (LysE YggA)
AM442_10665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM442_10670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM442_10675	COG1045	serine acetyltransferase
AM442_10690	COG0583	DNA-binding transcription factor activity
AM442_10695	COG0625	glutathione transferase activity
AM442_10700	COG0625	glutathione transferase activity
AM442_10705	COG0583	DNA-binding transcription factor activity
AM442_10715	COG1346	cytolysis
AM442_10735	COG2814	Major facilitator Superfamily
AM442_10745	COG0583	DNA-binding transcription factor activity
AM442_10755	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AM442_10760	COG3052	prosthetic group binding
AM442_10780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM442_10800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM442_10810	COG1294	oxidase, subunit
AM442_10815	COG1271	oxidase subunit
AM442_10840	COG0477	Major facilitator Superfamily
AM442_10850	COG3316	Transposase and inactivated derivatives
AM442_10870	COG3316	Transposase and inactivated derivatives
AM442_10885	COG0583	DNA-binding transcription factor activity
AM442_10895	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AM442_10910	COG0640	Transcriptional regulator
AM442_10915	COG0798	PFAM Bile acid sodium symporter
AM442_10920	COG0583	DNA-binding transcription factor activity
AM442_10935	COG3634	alkyl hydroperoxide reductase activity
AM442_10980	COG1301	dicarboxylic acid transport
AM442_10985	COG0436	Aminotransferase
AM442_10995	COG0386	Belongs to the glutathione peroxidase family
AM442_11010	COG0436	Aminotransferase
AM442_11035	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AM442_11060	COG0012	GTP binding
AM442_11065	COG2011	ABC-type metal ion transport system permease component
AM442_11070	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM442_11080	COG1464	Belongs to the NlpA lipoprotein family
AM442_11110	COG0765	amino acid transport
AM442_11115	COG0765	amino acid transport
AM442_11120	COG1126	abc transporter atp-binding protein
AM442_11130	COG1522	sequence-specific DNA binding
AM442_11145	COG1309	transcriptional regulator
AM442_11180	COG0583	DNA-binding transcription factor activity
AM442_11190	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM442_11200	COG0697	spore germination
AM442_11230	COG3121	Chaperone
AM442_11235	COG3539	Fimbrial protein
AM442_11260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM442_11260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM442_11305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM442_11315	COG2353	YceI-like domain
AM442_11325	COG3698	Phosphodiester glycosidase
AM442_11340	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AM442_11345	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM442_11345	COG0506	proline dehydrogenase activity
AM442_11345	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM442_11355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM442_11360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM442_11380	COG1132	(ABC) transporter
AM442_11385	COG3122	Protein conserved in bacteria
AM442_11390	COG3619	membrane
AM442_11400	COG0640	Transcriptional regulator
AM442_11410	COG2850	peptidyl-arginine hydroxylation
AM442_11415	COG0424	maF-like protein
AM442_11435	COG0191	fructose-bisphosphate aldolase activity
AM442_11440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM442_11455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AM442_11465	COG1192	Involved in chromosome partitioning
AM442_11470	COG1475	DNA binding
AM442_11475	COG0811	peptide transport
AM442_11485	COG1132	(ABC) transporter
AM442_11490	COG1663	tetraacyldisaccharide 4'-kinase activity
AM442_11510	COG0084	hydrolase, TatD family'
AM442_11525	COG2165	general secretion pathway protein
AM442_11555	COG0590	tRNA wobble adenosine to inosine editing
AM442_11575	COG0776	regulation of translation
AM442_11605	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM442_11610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AM442_11660	COG0339	signal peptide processing
AM442_11670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM442_11705	COG0702	epimerase
AM442_11710	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM442_11730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AM442_11760	COG0316	Belongs to the HesB IscA family
AM442_11765	COG0822	iron-sulfur transferase activity
AM442_11790	COG0776	regulation of translation
AM442_11795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM442_11800	COG2207	Transcriptional regulator
AM442_11805	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM442_11810	COG1960	acyl-CoA dehydrogenase activity
AM442_11815	COG1960	acyl-CoA dehydrogenase activity
AM442_11830	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM442_11850	COG4264	IucA IucC family
AM442_11855	COG4264	IucA IucC family
AM442_11915	COG0406	alpha-ribazole phosphatase activity
AM442_11930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM442_11935	COG0730	response to heat
AM442_11955	COG4773	Receptor
AM442_11960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM442_11975	COG1131	(ABC) transporter
AM442_11980	COG0842	Transport permease protein
AM442_11985	COG0842	Transport permease protein
AM442_12070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AM442_12130	COG1073	alpha beta
AM442_12140	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_12150	COG2207	Transcriptional regulator
AM442_12160	COG2205	protein histidine kinase activity
AM442_12165	COG0745	RESPONSE REGULATOR receiver
AM442_12170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM442_12175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM442_12190	COG2072	flavoprotein involved in K transport
AM442_12210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM442_12230	COG3938	Belongs to the proline racemase family
AM442_12245	COG2267	carboxylic ester hydrolase activity
AM442_12255	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_12275	COG2223	nitrite transmembrane transporter activity
AM442_12285	COG0697	spore germination
AM442_12290	COG0412	Dienelactone hydrolase
AM442_12295	COG1609	Transcriptional regulator
AM442_12300	COG1346	cytolysis
AM442_12315	COG0028	Belongs to the TPP enzyme family
AM442_12330	COG0483	inositol monophosphate 1-phosphatase activity
AM442_12355	COG0028	Belongs to the TPP enzyme family
AM442_12365	COG1609	Transcriptional regulator
AM442_12390	COG0494	nUDIX hydrolase
AM442_12395	COG0656	L-ascorbic acid biosynthetic process
AM442_12410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM442_12475	COG0732	type I restriction modification DNA specificity domain
AM442_12485	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AM442_12500	COG1535	isochorismatase
AM442_12500	COG3433	isochorismatase activity
AM442_12505	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_12510	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AM442_12515	COG4149	molybdate abc transporter
AM442_12520	COG0725	ABC transporter, periplasmic molybdate-binding protein
AM442_12530	COG4638	Rieske (2fe-2S)
AM442_12535	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AM442_12540	COG0543	2 iron, 2 sulfur cluster binding
AM442_12540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM442_12555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM442_12565	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_12570	COG0412	Dienelactone hydrolase
AM442_12580	COG2207	Transcriptional regulator
AM442_12585	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_12590	COG2610	gluconate transmembrane transporter activity
AM442_12600	COG1309	transcriptional regulator
AM442_12620	COG0583	DNA-binding transcription factor activity
AM442_12635	COG2031	fatty acid transporter
AM442_12640	COG0183	Belongs to the thiolase family
AM442_12645	COG0583	DNA-binding transcription factor activity
AM442_12650	COG0583	DNA-binding transcription factor activity
AM442_12665	COG1027	Aspartate ammonia-lyase
AM442_12675	COG0477	Major facilitator Superfamily
AM442_12695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM442_12700	COG4521	taurine ABC transporter
AM442_12725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AM442_12730	COG1733	regulation of RNA biosynthetic process
AM442_12735	COG2207	Transcriptional regulator
AM442_12735	COG3708	Transcriptional regulator
AM442_12750	COG0730	response to heat
AM442_12760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM442_12760	COG3453	Protein conserved in bacteria
AM442_12770	COG3781	membrane
AM442_12775	COG1063	alcohol dehydrogenase
AM442_12785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM442_12790	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM442_12795	COG0022	dehydrogenase e1 component
AM442_12800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM442_12810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM442_12825	COG3706	GGDEF domain
AM442_12840	COG0133	tryptophan synthase activity
AM442_12850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM442_12905	COG0753	catalase activity
AM442_12920	COG1012	belongs to the aldehyde dehydrogenase family
AM442_12935	COG3162	membrane
AM442_12950	COG3829	transcription factor binding
AM442_12955	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_12960	COG1960	acyl-CoA dehydrogenase activity
AM442_12975	COG3231	kanamycin kinase activity
AM442_12980	COG1012	belongs to the aldehyde dehydrogenase family
AM442_13000	COG2186	Transcriptional regulator
AM442_13010	COG0583	DNA-binding transcription factor activity
AM442_13015	COG4948	Mandelate Racemase Muconate Lactonizing
AM442_13020	COG4829	muconolactone delta-isomerase
AM442_13030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM442_13035	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM442_13040	COG0183	Belongs to the thiolase family
AM442_13045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM442_13050	COG1012	belongs to the aldehyde dehydrogenase family
AM442_13060	COG3733	amine oxidase
AM442_13070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM442_13080	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_13090	COG4638	Rieske (2fe-2S)
AM442_13110	COG0154	amidase activity
AM442_13120	COG2814	Major facilitator Superfamily
AM442_13145	COG1960	acyl-CoA dehydrogenase activity
AM442_13150	COG0583	DNA-binding transcription factor activity
AM442_13155	COG1414	Transcriptional regulator
AM442_13170	COG2391	methyltransferase activity
AM442_13180	COG4993	Dehydrogenase
AM442_13185	COG3659	wide pore channel activity
AM442_13190	COG3420	alginic acid biosynthetic process
AM442_13195	COG0710	3-dehydroquinate dehydratase activity
AM442_13200	COG3485	protocatechuate 3,4-dioxygenase
AM442_13205	COG3485	protocatechuate 3,4-dioxygenase
AM442_13210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM442_13215	COG2271	Major facilitator Superfamily
AM442_13220	COG0596	Alpha beta hydrolase
AM442_13225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM442_13230	COG0183	Belongs to the thiolase family
AM442_13235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM442_13240	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM442_13250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AM442_13255	COG2323	membrane
AM442_13300	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM442_13300	COG1902	pentaerythritol trinitrate reductase activity
AM442_13315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM442_13325	COG0542	response to heat
AM442_13330	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AM442_13360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM442_13365	COG0569	domain protein
AM442_13370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AM442_13385	COG4774	siderophore transport
AM442_13390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM442_13400	COG1585	Membrane protein implicated in regulation of membrane protease activity
AM442_13425	COG1294	oxidase, subunit
AM442_13430	COG4890	Cyd operon protein YbgT
AM442_13445	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AM442_13455	COG0552	protein localization to endoplasmic reticulum
AM442_13480	COG0517	IMP dehydrogenase activity
AM442_13480	COG0516	GMP reductase activity
AM442_13485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM442_13490	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AM442_13500	COG0583	DNA-binding transcription factor activity
AM442_13505	COG0024	Methionine aminopeptidase
AM442_13535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM442_13535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM442_13540	COG1105	Belongs to the carbohydrate kinase PfkB family
AM442_13545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM442_13545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM442_13545	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AM442_13610	COG0776	regulation of translation
AM442_13665	COG4373	Mu-like prophage FluMu protein gp28
AM442_13690	COG4383	Mu-like prophage protein gp29
AM442_13695	COG2369	cell adhesion
AM442_13795	COG3299	homolog of phage Mu protein gp47
AM442_13825	COG5001	Diguanylate cyclase
AM442_13825	COG3300	MHYT domain
AM442_13840	COG2135	peptidase activity
AM442_13845	COG0659	secondary active sulfate transmembrane transporter activity
AM442_13860	COG1113	amino acid transport
AM442_13870	COG1522	sequence-specific DNA binding
AM442_13905	COG1011	Hydrolase
AM442_13910	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AM442_13920	COG2137	regulation of response to DNA damage stimulus
AM442_13935	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM442_13970	COG0575	Belongs to the CDS family
AM442_13975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM442_14000	COG3852	Histidine kinase
AM442_14005	COG2204	response regulator
AM442_14065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM442_14070	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AM442_14090	COG0697	spore germination
AM442_14095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM442_14105	COG0303	'Molybdopterin
AM442_14110	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM442_14110	COG0315	cyclic pyranopterin monophosphate synthase activity
AM442_14125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AM442_14130	COG0243	molybdopterin cofactor binding
AM442_14140	COG0243	molybdopterin cofactor binding
AM442_14145	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM442_14150	COG2146	nitrite reductase [NAD(P)H] activity
AM442_14150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM442_14160	COG0745	RESPONSE REGULATOR receiver
AM442_14165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM442_14165	COG1116	anion transmembrane transporter activity
AM442_14180	COG0511	ligase activity, forming carbon-carbon bonds
AM442_14200	COG2814	Major facilitator Superfamily
AM442_14230	COG0069	glutamate synthase activity
AM442_14250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AM442_14260	COG1454	alcohol dehydrogenase
AM442_14265	COG0824	Thioesterase
AM442_14275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AM442_14290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AM442_14310	COG0183	Belongs to the thiolase family
AM442_14320	COG0583	DNA-binding transcription factor activity
AM442_14335	COG1522	sequence-specific DNA binding
AM442_14340	COG3135	benzoate transporter
AM442_14350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AM442_14370	COG0589	response to stress
AM442_14375	COG0488	(ABC) transporter
AM442_14400	COG4773	Receptor
AM442_14435	COG0668	transmembrane transport
AM442_14445	COG1309	transcriptional regulator
AM442_14465	COG1605	Chorismate mutase
AM442_14485	COG0308	aminopeptidase N
AM442_14510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM442_14515	COG1454	alcohol dehydrogenase
AM442_14535	COG0531	amino acid
AM442_14540	COG4303	Ethanolamine ammonia lyase large subunit
AM442_14545	COG4302	ethanolamine ammonia-lyase activity
AM442_14550	COG0519	Catalyzes the synthesis of GMP from XMP
AM442_14550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM442_14585	COG1923	regulation of RNA biosynthetic process
AM442_14595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM442_14600	COG0802	atpase or kinase
AM442_14620	COG1187	pseudouridine synthase activity
AM442_14635	COG0583	DNA-binding transcription factor activity
AM442_14650	COG2814	Major facilitator Superfamily
AM442_14655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM442_14690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM442_14795	COG0592	DNA-directed DNA polymerase activity
AM442_14835	COG2026	Addiction module toxin, RelE StbE family
AM442_15030	COG1484	DNA-dependent DNA replication
AM442_15125	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM442_15165	COG0729	surface antigen
AM442_15185	COG0174	glutamine synthetase
AM442_15190	COG0745	RESPONSE REGULATOR receiver
AM442_15195	COG2205	protein histidine kinase activity
AM442_15205	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AM442_15210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AM442_15235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM442_15240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM442_15245	COG1960	acyl-CoA dehydrogenase activity
AM442_15275	COG0583	DNA-binding transcription factor activity
AM442_15295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM442_15305	COG3658	cytochrome
AM442_15310	COG1215	transferase activity, transferring glycosyl groups
AM442_15315	COG0726	polysaccharide deacetylase
AM442_15315	COG1649	PFAM Uncharacterised BCR, COG1649
AM442_15345	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM442_15350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM442_15360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AM442_15385	COG0305	Participates in initiation and elongation during chromosome replication
AM442_15390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM442_15400	COG1305	Transglutaminase-like
AM442_15410	COG2308	Evidence 4 Homologs of previously reported genes of
AM442_15445	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AM442_15450	COG0138	bifunctional purine biosynthesis protein purh
AM442_15455	COG0151	Belongs to the GarS family
AM442_15460	COG1464	Belongs to the NlpA lipoprotein family
AM442_15465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM442_15470	COG2011	ABC-type metal ion transport system permease component
AM442_15475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM442_15485	COG1301	dicarboxylic acid transport
AM442_15515	COG1794	racemase activity, acting on amino acids and derivatives
AM442_15525	COG3008	intermembrane lipid transfer
AM442_15525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AM442_15530	COG2995	paraquat-inducible protein a
AM442_15540	COG2985	domain, Protein
AM442_15575	COG0477	Major facilitator Superfamily
AM442_15630	COG2186	Transcriptional regulator
AM442_15640	COG0786	glutamate:sodium symporter activity
AM442_15645	COG3243	poly(R)-hydroxyalkanoic acid synthase
AM442_15670	COG3111	PFAM Bacterial OB fold (BOF) protein
AM442_15760	COG2831	hemolysin activation secretion protein
AM442_15810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AM442_15815	COG1610	YqeY-like protein
AM442_15820	COG4783	chaperone-mediated protein folding
AM442_15845	COG1286	toxin biosynthetic process
AM442_15875	COG0778	Nitroreductase
AM442_15885	COG0513	Belongs to the DEAD box helicase family
AM442_15905	COG2363	Small membrane protein
AM442_15935	COG1234	tRNA 3'-trailer cleavage
AM442_15940	COG2195	Cleaves the N-terminal amino acid of tripeptides
AM442_15950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AM442_15960	COG2819	hydrolase of the alpha beta superfamily
AM442_15965	COG1960	acyl-CoA dehydrogenase activity
AM442_15970	COG1301	dicarboxylic acid transport
AM442_15980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AM442_15985	COG3139	Protein of unknown function (DUF1315)
AM442_15990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM442_15995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM442_16005	COG0494	nUDIX hydrolase
AM442_16015	COG0642	Histidine kinase
AM442_16020	COG0745	RESPONSE REGULATOR receiver
AM442_16040	COG1720	tRNA m6t6A37 methyltransferase activity
AM442_16055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM442_16065	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM442_16075	COG4598	ABC transporter
AM442_16080	COG4160	amino acid transport
AM442_16085	COG4215	(ABC) transporter
AM442_16100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM442_16190	COG1724	mRNA binding
AM442_16195	COG1598	PFAM Uncharacterised protein family UPF0150
AM442_16260	COG0740	serine-type endopeptidase activity
AM442_16270	COG4695	Portal protein
AM442_16485	COG1131	(ABC) transporter
AM442_16490	COG0842	Transport permease protein
AM442_16505	COG0772	Belongs to the SEDS family
AM442_16510	COG2951	lytic endotransglycosylase activity
AM442_16535	COG2207	Transcriptional regulator
AM442_16550	COG0052	Belongs to the universal ribosomal protein uS2 family
AM442_16555	COG0024	Methionine aminopeptidase
AM442_16565	COG2223	nitrite transmembrane transporter activity
AM442_16575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM442_16580	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM442_16585	COG1960	acyl-CoA dehydrogenase activity
AM442_16600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AM442_16605	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AM442_16610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM442_16640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM442_16645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AM442_16650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM442_16685	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AM442_16700	COG3104	oligopeptide transport
AM442_16710	COG0512	Glutamine amidotransferase of anthranilate synthase
AM442_16745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM442_16780	COG3739	integral membrane protein
AM442_16795	COG1169	isochorismate synthase
AM442_16805	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AM442_16810	COG5265	(ABC) transporter
AM442_16815	COG1132	(ABC) transporter
AM442_16830	COG1535	isochorismatase
AM442_16830	COG3433	isochorismatase activity
AM442_16835	COG1021	2,3-dihydroxybenzoate-AMP ligase
AM442_16840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM442_16850	COG4774	siderophore transport
AM442_16855	COG4607	ABC-type enterochelin transport system periplasmic component
AM442_16860	COG4604	ABC transporter, ATP-binding protein
AM442_16865	COG4605	iron ion homeostasis
AM442_16870	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM442_16875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM442_16890	COG2964	Protein conserved in bacteria
AM442_16900	COG1741	Belongs to the pirin family
AM442_16925	COG2879	small protein
AM442_16930	COG1966	Carbon starvation protein
AM442_16950	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AM442_16970	COG2211	Major facilitator Superfamily
AM442_16975	COG1067	ATP-dependent peptidase activity
AM442_16980	COG0583	DNA-binding transcription factor activity
AM442_17005	COG1686	Belongs to the peptidase S11 family
AM442_17010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM442_17050	COG0616	signal peptide processing
AM442_17055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AM442_17065	COG0573	inorganic phosphate transmembrane transporter activity
AM442_17070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM442_17075	COG1113	amino acid transport
AM442_17080	COG3961	Belongs to the TPP enzyme family
AM442_17085	COG1522	sequence-specific DNA binding
AM442_17095	COG0076	glutamate decarboxylase activity
AM442_17100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM442_17110	COG1309	transcriptional regulator
AM442_17125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM442_17160	COG0352	thiamine-phosphate diphosphorylase activity
AM442_17185	COG0612	Peptidase, M16
AM442_17200	COG0583	DNA-binding transcription factor activity
AM442_17205	COG0477	Major facilitator Superfamily
AM442_17230	COG1187	pseudouridine synthase activity
AM442_17260	COG1252	NADH dehydrogenase
AM442_17270	COG0415	Belongs to the DNA photolyase family
AM442_17285	COG1215	transferase activity, transferring glycosyl groups
AM442_17315	COG2070	2-Nitropropane dioxygenase
AM442_17370	COG0556	nucleotide-excision repair
AM442_17420	COG4221	oxidoreductase activity
AM442_17430	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AM442_17435	COG1381	Involved in DNA repair and RecF pathway recombination
AM442_17445	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AM442_17460	COG0681	Belongs to the peptidase S26 family
AM442_17475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM442_17495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AM442_17500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM442_17505	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AM442_17515	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AM442_17520	COG4208	sulfate ABC transporter
AM442_17525	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AM442_17530	COG0583	DNA-binding transcription factor activity
AM442_17535	COG4625	pathogenesis
AM442_17550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AM442_17565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM442_17575	COG1051	belongs to the nudix hydrolase family
AM442_17575	COG1056	cytidyltransferase-related domain
AM442_17580	COG1024	Enoyl-CoA hydratase
AM442_17590	COG2814	Major facilitator Superfamily
AM442_17595	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM442_17595	COG0047	phosphoribosylformylglycinamidine synthase activity
AM442_17615	COG1473	amidohydrolase
AM442_17620	COG0824	Thioesterase
AM442_17640	COG0823	Involved in the tonB-independent uptake of proteins
AM442_17660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM442_17695	COG0628	permease
AM442_17705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM442_17710	COG0596	Alpha beta hydrolase
AM442_17715	COG0616	signal peptide processing
AM442_17715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM442_17725	COG0658	competence protein
AM442_17725	COG2333	competence protein COMEC
AM442_17730	COG1136	(ABC) transporter
AM442_17735	COG4591	ABC-type transport system involved in lipoprotein release permease component
AM442_17765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM442_17825	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AM442_17830	COG1280	lysine exporter protein (LysE YggA)
AM442_17840	COG0019	diaminopimelate decarboxylase activity
AM442_17850	COG1113	amino acid transport
AM442_17865	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AM442_17875	COG3339	Conserved Protein
AM442_17880	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AM442_17885	COG0243	molybdopterin cofactor binding
AM442_17890	COG1929	Belongs to the glycerate kinase type-1 family
AM442_17905	COG0778	Nitroreductase
AM442_17955	COG3811	Belongs to the UPF0386 family
AM442_17965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM442_17985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM442_18010	COG0741	lytic transglycosylase activity
AM442_18030	COG0584	glycerophosphoryl diester phosphodiesterase
AM442_18065	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM442_18085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM442_18090	COG0477	Major facilitator Superfamily
AM442_18140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AM442_18145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM442_18155	COG1534	Rna-binding protein
AM442_18175	COG0505	Belongs to the CarA family
AM442_18195	COG0589	response to stress
AM442_18210	COG2843	Capsule synthesis protein
AM442_18230	COG2321	neutral zinc metallopeptidase
AM442_18235	COG2354	Protein conserved in bacteria
AM442_18255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM442_18280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM442_18285	COG1053	succinate dehydrogenase
AM442_18290	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AM442_18295	COG2009	succinate dehydrogenase
AM442_18330	COG2921	Belongs to the UPF0250 family
AM442_18335	COG0321	lipoyl(octanoyl) transferase activity
AM442_18370	COG1733	regulation of RNA biosynthetic process
AM442_18375	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AM442_18380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AM442_18380	COG1648	precorrin-2 dehydrogenase activity
AM442_18395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AM442_18420	COG0215	cysteine-tRNA ligase activity
AM442_18425	COG0671	phosphoesterase, PA-phosphatase related
AM442_18430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM442_18440	COG1538	Outer membrane efflux protein
AM442_18445	COG0393	Putative heavy-metal-binding
AM442_18450	COG0393	Putative heavy-metal-binding
AM442_18460	COG1028	Short-chain dehydrogenase reductase Sdr
AM442_18470	COG0525	valine-tRNA ligase activity
AM442_18490	COG0583	DNA-binding transcription factor activity
AM442_18500	COG0004	ammonium transporteR
AM442_18515	COG0642	Histidine kinase
AM442_18520	COG0745	RESPONSE REGULATOR receiver
AM442_18525	COG2194	sulfuric ester hydrolase activity
AM442_18560	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM442_18575	COG2315	Protein conserved in bacteria
AM442_18580	COG0142	geranyltranstransferase activity
AM442_18585	COG2828	Protein conserved in bacteria
AM442_18590	COG1113	amino acid transport
AM442_18610	COG2207	Transcriptional regulator
AM442_18635	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM442_18655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM442_18665	COG1530	ribonuclease E activity
AM442_18670	COG0424	maF-like protein
AM442_18675	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AM442_18680	COG1792	Involved in formation and maintenance of cell shape
AM442_18685	COG1077	Cell shape determining protein MreB Mrl
AM442_18690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM442_18700	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM442_18725	COG3590	peptidase
AM442_18730	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AM442_18735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM442_18740	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM442_18745	COG1115	amino acid carrier protein
AM442_18765	COG2814	Major facilitator Superfamily
AM442_18770	COG1289	transmembrane transporter activity
AM442_18820	COG1376	ErfK ybiS ycfS ynhG family protein
AM442_18825	COG2832	Protein of unknown function (DUF454)
AM442_18835	COG5510	response to toxic substance
AM442_18855	COG0840	transmembrane signaling receptor activity
AM442_18895	COG3422	double-strand break repair
AM442_18900	COG2824	Alkylphosphonate utilization operon protein PhnA
AM442_18905	COG3189	MarR family transcriptional regulator
AM442_18915	COG0354	folic acid binding
AM442_18920	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM442_18935	COG1902	pentaerythritol trinitrate reductase activity
AM442_18940	COG4772	TonB-dependent receptor
AM442_18945	COG2094	Belongs to the DNA glycosylase MPG family
AM442_18975	COG2233	PERMEase
AM442_18985	COG0833	amino acid
AM442_18990	COG1690	Belongs to the RtcB family
AM442_18995	COG2885	chlorophyll binding
AM442_18995	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM442_19005	COG0183	Belongs to the thiolase family
AM442_19025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM442_19045	COG2207	Transcriptional regulator
AM442_19050	COG0183	Belongs to the thiolase family
AM442_19080	COG1272	protein, Hemolysin III
AM442_19085	COG0477	Major facilitator Superfamily
AM442_19100	COG0450	alkyl hydroperoxide reductase
AM442_19120	COG0285	dihydrofolate synthase activity
AM442_19155	COG0133	tryptophan synthase activity
AM442_19165	COG4206	TonB-dependent receptor
AM442_19170	COG2096	Adenosyltransferase
AM442_19175	COG0584	glycerophosphoryl diester phosphodiesterase
AM442_19190	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AM442_19195	COG0745	RESPONSE REGULATOR receiver
AM442_19200	COG2205	protein histidine kinase activity
AM442_19210	COG1960	acyl-CoA dehydrogenase activity
AM442_19215	COG1960	acyl-CoA dehydrogenase activity
AM442_19300	COG0438	transferase activity, transferring glycosyl groups
AM442_19305	COG0463	Glycosyl transferase, family 2
AM442_19310	COG0726	polysaccharide deacetylase
AM442_19330	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AM442_19395	COG1862	Preprotein translocase
AM442_19405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM442_19505	COG3853	Toxic anion resistance protein (TelA)
AM442_19525	COG1475	DNA binding
AM442_19605	COG1525	nuclease
AM442_19675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM442_19755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM442_19790	COG0741	lytic transglycosylase activity
AM442_19825	COG2826	transposase and inactivated derivatives, IS30 family
AM442_19895	COG0484	heat shock protein binding