locus-tag	class	description
AM457_00010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM457_00030	COG0463	Glycosyl transferase, family 2
AM457_00060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AM457_00065	COG1280	lysine exporter protein (LysE YggA)
AM457_00080	COG0019	diaminopimelate decarboxylase activity
AM457_00090	COG1113	amino acid transport
AM457_00105	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AM457_00115	COG3339	Conserved Protein
AM457_00120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AM457_00125	COG0243	molybdopterin cofactor binding
AM457_00130	COG1929	Belongs to the glycerate kinase type-1 family
AM457_00145	COG0778	Nitroreductase
AM457_00170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM457_00185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AM457_00210	COG0741	lytic transglycosylase activity
AM457_00230	COG0584	glycerophosphoryl diester phosphodiesterase
AM457_00235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM457_00260	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM457_00280	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AM457_00285	COG0477	Major facilitator Superfamily
AM457_00335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AM457_00340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM457_00365	COG0505	Belongs to the CarA family
AM457_00385	COG0589	response to stress
AM457_00400	COG2843	Capsule synthesis protein
AM457_00420	COG2321	neutral zinc metallopeptidase
AM457_00425	COG2354	Protein conserved in bacteria
AM457_00455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM457_00480	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AM457_00485	COG1053	succinate dehydrogenase
AM457_00490	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AM457_00495	COG2009	succinate dehydrogenase
AM457_00530	COG2921	Belongs to the UPF0250 family
AM457_00535	COG0321	lipoyl(octanoyl) transferase activity
AM457_00550	COG0531	amino acid
AM457_00560	COG1733	regulation of RNA biosynthetic process
AM457_00565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AM457_00570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AM457_00570	COG1648	precorrin-2 dehydrogenase activity
AM457_00585	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AM457_00615	COG0671	phosphoesterase, PA-phosphatase related
AM457_00620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM457_00630	COG1538	Outer membrane efflux protein
AM457_00635	COG0393	Putative heavy-metal-binding
AM457_00640	COG0393	Putative heavy-metal-binding
AM457_00650	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_00660	COG0525	valine-tRNA ligase activity
AM457_00680	COG0583	DNA-binding transcription factor activity
AM457_00690	COG0004	ammonium transporteR
AM457_00700	COG0642	Histidine kinase
AM457_00705	COG0745	RESPONSE REGULATOR receiver
AM457_00710	COG2194	sulfuric ester hydrolase activity
AM457_00730	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM457_00745	COG2315	Protein conserved in bacteria
AM457_00750	COG0142	geranyltranstransferase activity
AM457_00755	COG2828	Protein conserved in bacteria
AM457_00760	COG1113	amino acid transport
AM457_00780	COG2207	Transcriptional regulator
AM457_00805	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM457_00825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM457_00835	COG1530	ribonuclease E activity
AM457_00840	COG0424	maF-like protein
AM457_00845	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AM457_00850	COG1792	Involved in formation and maintenance of cell shape
AM457_00855	COG1077	Cell shape determining protein MreB Mrl
AM457_00860	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM457_00870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AM457_00895	COG3590	peptidase
AM457_00900	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AM457_00905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM457_00910	COG1752	Esterase of the alpha-beta hydrolase superfamily
AM457_00915	COG1115	amino acid carrier protein
AM457_00935	COG2814	Major facilitator Superfamily
AM457_00940	COG1289	transmembrane transporter activity
AM457_00990	COG1376	ErfK ybiS ycfS ynhG family protein
AM457_00995	COG2832	Protein of unknown function (DUF454)
AM457_01005	COG5510	response to toxic substance
AM457_01020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM457_01035	COG0840	transmembrane signaling receptor activity
AM457_01075	COG3422	double-strand break repair
AM457_01080	COG2824	Alkylphosphonate utilization operon protein PhnA
AM457_01085	COG3189	MarR family transcriptional regulator
AM457_01095	COG0354	folic acid binding
AM457_01100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM457_01110	COG0679	Auxin Efflux Carrier
AM457_01115	COG1902	pentaerythritol trinitrate reductase activity
AM457_01120	COG4772	TonB-dependent receptor
AM457_01165	COG2233	PERMEase
AM457_01175	COG0833	amino acid
AM457_01180	COG1690	Belongs to the RtcB family
AM457_01190	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM457_01190	COG2885	chlorophyll binding
AM457_01200	COG0183	Belongs to the thiolase family
AM457_01220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM457_01240	COG2207	Transcriptional regulator
AM457_01245	COG0183	Belongs to the thiolase family
AM457_01275	COG1272	protein, Hemolysin III
AM457_01280	COG0477	Major facilitator Superfamily
AM457_01295	COG0450	alkyl hydroperoxide reductase
AM457_01315	COG0285	dihydrofolate synthase activity
AM457_01350	COG0133	tryptophan synthase activity
AM457_01365	COG2096	Adenosyltransferase
AM457_01385	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AM457_01390	COG0745	RESPONSE REGULATOR receiver
AM457_01395	COG2205	protein histidine kinase activity
AM457_01405	COG1960	acyl-CoA dehydrogenase activity
AM457_01410	COG1960	acyl-CoA dehydrogenase activity
AM457_01485	COG0438	transferase activity, transferring glycosyl groups
AM457_01490	COG0463	Glycosyl transferase, family 2
AM457_01495	COG0726	polysaccharide deacetylase
AM457_01515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AM457_01520	COG2205	protein histidine kinase activity
AM457_01550	COG1862	Preprotein translocase
AM457_01560	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AM457_01565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AM457_01575	COG3781	membrane
AM457_01580	COG0613	PHP domain protein
AM457_01590	COG2350	Protein conserved in bacteria
AM457_01620	COG1607	acyl-coa hydrolase
AM457_01635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM457_01635	COG3453	Protein conserved in bacteria
AM457_01690	COG2199	diguanylate cyclase activity
AM457_01700	COG1408	metallophosphoesterase
AM457_01705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM457_01715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AM457_01735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AM457_01740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AM457_01755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AM457_01765	COG2969	positive regulation of protein catabolic process
AM457_01785	COG1960	acyl-CoA dehydrogenase activity
AM457_01790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM457_01805	COG1309	transcriptional regulator
AM457_01810	COG1960	acyl-CoA dehydrogenase activity
AM457_01855	COG1183	phosphatidylcholine synthase activity
AM457_01860	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AM457_01890	COG0739	heme binding
AM457_01890	COG0741	lytic transglycosylase activity
AM457_01890	COG1196	nuclear chromosome segregation
AM457_01900	COG1702	phosphate starvation-inducible protein PhoH
AM457_01935	COG1295	ribonuclease BN
AM457_01940	COG0697	spore germination
AM457_01945	COG2169	Transcriptional regulator
AM457_01950	COG0179	Fumarylacetoacetate (FAA) hydrolase
AM457_01995	COG0557	exoribonuclease II activity
AM457_02000	COG0339	signal peptide processing
AM457_02005	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AM457_02035	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AM457_02040	COG1960	acyl-CoA dehydrogenase activity
AM457_02065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AM457_02075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AM457_02195	COG0626	cystathionine gamma-synthase activity
AM457_02200	COG0433	COG0433 Predicted ATPase
AM457_02210	COG1017	nitric oxide dioxygenase activity
AM457_02210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM457_02215	COG1959	2 iron, 2 sulfur cluster binding
AM457_02230	COG1301	dicarboxylic acid transport
AM457_02235	COG1946	Acyl-CoA thioesterase
AM457_02255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AM457_02260	COG1040	competence protein
AM457_02265	COG0494	nUDIX hydrolase
AM457_02275	COG0598	Magnesium transport protein CorA
AM457_02285	COG2854	intermembrane phospholipid transfer
AM457_02295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AM457_02300	COG1127	ABC transporter
AM457_02305	COG0513	Belongs to the DEAD box helicase family
AM457_02325	COG0408	coproporphyrinogen oxidase activity
AM457_02340	COG1960	acyl-CoA dehydrogenase activity
AM457_02350	COG1983	PspC domain protein
AM457_02355	COG0517	IMP dehydrogenase activity
AM457_02400	COG0583	DNA-binding transcription factor activity
AM457_02445	COG1012	belongs to the aldehyde dehydrogenase family
AM457_02455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM457_02460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM457_02465	COG0833	amino acid
AM457_02495	COG1192	Involved in chromosome partitioning
AM457_02500	COG0628	permease
AM457_02510	COG1289	transmembrane transporter activity
AM457_02525	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM457_02530	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AM457_02540	COG0277	FAD linked oxidase domain protein
AM457_02545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM457_02570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AM457_02575	COG5380	lipid catabolic process
AM457_02595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AM457_02645	COG0194	GDP metabolic process
AM457_02660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM457_02680	COG3307	-O-antigen
AM457_02695	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AM457_02700	COG1704	LemA family
AM457_02710	COG0493	'glutamate synthase
AM457_02715	COG0069	glutamate synthase activity
AM457_02715	COG0070	glutamate synthase
AM457_02715	COG0067	glutamate synthase
AM457_02765	COG2226	methyltransferase
AM457_02780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AM457_02785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AM457_02830	COG0833	amino acid
AM457_02895	COG0488	(ABC) transporter
AM457_02905	COG4221	oxidoreductase activity
AM457_02910	COG0659	secondary active sulfate transmembrane transporter activity
AM457_02920	COG0745	RESPONSE REGULATOR receiver
AM457_02935	COG0427	acetyl-CoA hydrolase
AM457_02965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AM457_03005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AM457_03060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM457_03070	COG2249	NAD(P)H dehydrogenase (quinone) activity
AM457_03075	COG1733	regulation of RNA biosynthetic process
AM457_03110	COG0667	Aldo Keto reductase
AM457_03130	COG0583	DNA-binding transcription factor activity
AM457_03135	COG2814	Major facilitator Superfamily
AM457_03165	COG1335	isochorismatase
AM457_03175	COG1012	belongs to the aldehyde dehydrogenase family
AM457_03180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM457_03190	COG1113	amino acid transport
AM457_03200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AM457_03215	COG2814	Major facilitator Superfamily
AM457_03225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM457_03225	COG0351	phosphomethylpyrimidine kinase
AM457_03225	COG0352	thiamine-phosphate diphosphorylase activity
AM457_03245	COG1309	transcriptional regulator
AM457_03250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AM457_03255	COG3706	GGDEF domain
AM457_03265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM457_03275	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM457_03280	COG3162	membrane
AM457_03285	COG2205	protein histidine kinase activity
AM457_03285	COG2198	Histidine kinase
AM457_03285	COG0784	Response regulator, receiver
AM457_03310	COG1522	sequence-specific DNA binding
AM457_03315	COG1335	isochorismatase
AM457_03320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM457_03330	COG0668	transmembrane transport
AM457_03335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM457_03340	COG1519	Transferase
AM457_03345	COG1902	pentaerythritol trinitrate reductase activity
AM457_03365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AM457_03390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM457_03390	COG0426	domain, Protein
AM457_03395	COG4774	siderophore transport
AM457_03400	COG2119	membrane
AM457_03410	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM457_03420	COG4942	peptidase
AM457_03435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AM457_03445	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AM457_03465	COG0189	ligase activity
AM457_03495	COG0708	Exodeoxyribonuclease III
AM457_03500	COG1393	Belongs to the ArsC family
AM457_03515	COG3706	GGDEF domain
AM457_03550	COG2351	hydroxyisourate hydrolase activity
AM457_03555	COG2233	PERMEase
AM457_03565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM457_03575	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AM457_03580	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_03610	COG3409	Peptidoglycan-binding domain 1 protein
AM457_03610	COG5632	N-Acetylmuramoyl-L-alanine amidase
AM457_03610	COG1388	LysM domain
AM457_03615	COG3501	Rhs element vgr protein
AM457_03625	COG2918	glutathione biosynthetic process
AM457_03640	COG2733	membrane
AM457_03645	COG0436	Aminotransferase
AM457_03650	COG0534	Mate efflux family protein
AM457_03740	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AM457_03745	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AM457_03755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AM457_03810	COG1280	lysine exporter protein (LysE YggA)
AM457_03820	COG0546	phosphoglycolate phosphatase activity
AM457_03830	COG0010	Belongs to the arginase family
AM457_03860	COG2188	Transcriptional regulator
AM457_03870	COG0523	cobalamin synthesis protein
AM457_03880	COG1113	amino acid transport
AM457_03890	COG0625	glutathione transferase activity
AM457_03910	COG1683	Conserved Protein
AM457_03915	COG0534	Mate efflux family protein
AM457_03920	COG0385	Bile acid
AM457_03925	COG1335	isochorismatase
AM457_03930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM457_03950	COG2116	formate transmembrane transporter activity
AM457_03955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AM457_03960	COG2133	pyrroloquinoline quinone binding
AM457_03965	COG2983	Belongs to the UPF0260 family
AM457_03985	COG1194	a g-specific adenine glycosylase
AM457_04000	COG2818	Glycosylase
AM457_04005	COG1064	alcohol dehydrogenase
AM457_04010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM457_04025	COG0583	DNA-binding transcription factor activity
AM457_04030	COG0656	L-ascorbic acid biosynthetic process
AM457_04035	COG2814	Major facilitator Superfamily
AM457_04070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM457_04085	COG2233	PERMEase
AM457_04090	COG0583	DNA-binding transcription factor activity
AM457_04125	COG0733	neurotransmitter:sodium symporter activity
AM457_04165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AM457_04225	COG2951	lytic endotransglycosylase activity
AM457_04230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AM457_04250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AM457_04260	COG0671	phosphoesterase, PA-phosphatase related
AM457_04265	COG0861	Integral membrane protein TerC family
AM457_04275	COG0754	glutathionylspermidine amidase activity
AM457_04285	COG0402	S-adenosylhomocysteine deaminase activity
AM457_04300	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM457_04305	COG1230	cation diffusion facilitator family transporter
AM457_04320	COG0706	membrane insertase activity
AM457_04335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AM457_04345	COG0592	DNA-directed DNA polymerase activity
AM457_04355	COG0187	DNA topoisomerase II activity
AM457_04365	COG0586	Pfam SNARE associated Golgi protein
AM457_04370	COG0488	(ABC) transporter
AM457_04395	COG0596	Alpha beta hydrolase
AM457_04400	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AM457_04405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AM457_04450	COG1047	Peptidyl-prolyl cis-trans
AM457_04460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AM457_04465	COG0196	riboflavin kinase activity
AM457_04475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AM457_04480	COG1309	transcriptional regulator
AM457_04485	COG1116	anion transmembrane transporter activity
AM457_04490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM457_04495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM457_04500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM457_04505	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM457_04525	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_04530	COG0546	phosphoglycolate phosphatase activity
AM457_04590	COG3023	N-Acetylmuramoyl-L-alanine amidase
AM457_04595	COG0728	peptidoglycan biosynthetic process
AM457_04625	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AM457_04645	COG0438	transferase activity, transferring glycosyl groups
AM457_04655	COG0438	transferase activity, transferring glycosyl groups
AM457_04660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AM457_04670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AM457_04680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AM457_04695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM457_04705	COG2186	Transcriptional regulator
AM457_04715	COG0277	FAD linked oxidase domain protein
AM457_04720	COG1448	Aminotransferase
AM457_04730	COG1802	Transcriptional regulator
AM457_04745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AM457_04795	COG0564	pseudouridine synthase activity
AM457_04820	COG1522	sequence-specific DNA binding
AM457_04835	COG0251	oxidation-reduction process
AM457_04840	COG1113	amino acid transport
AM457_04845	COG1113	amino acid transport
AM457_04865	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM457_04870	COG1960	acyl-CoA dehydrogenase activity
AM457_04875	COG1024	Enoyl-CoA hydratase
AM457_04880	COG1024	Enoyl-CoA hydratase
AM457_04885	COG0477	Major facilitator Superfamily
AM457_04890	COG3916	Acyl-homoserine-lactone synthase
AM457_04905	COG2197	response regulator
AM457_04915	COG1960	acyl-CoA dehydrogenase activity
AM457_04920	COG3321	synthase
AM457_04920	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AM457_04920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AM457_04920	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AM457_04940	COG2267	carboxylic ester hydrolase activity
AM457_04960	COG0271	Belongs to the BolA IbaG family
AM457_04970	COG1192	Involved in chromosome partitioning
AM457_04985	COG0586	Pfam SNARE associated Golgi protein
AM457_04990	COG2259	Doxx family
AM457_04995	COG4399	Belongs to the UPF0754 family
AM457_05000	COG0519	Catalyzes the synthesis of GMP from XMP
AM457_05000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM457_05045	COG0281	malic enzyme
AM457_05050	COG2837	iron assimilation
AM457_05055	COG1280	lysine exporter protein (LysE YggA)
AM457_05060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AM457_05065	COG1121	(ABC) transporter
AM457_05130	COG0386	Belongs to the glutathione peroxidase family
AM457_05145	COG1309	transcriptional regulator
AM457_05150	COG0697	spore germination
AM457_05160	COG0758	DNA mediated transformation
AM457_05180	COG4771	TonB-dependent receptor
AM457_05195	COG1309	transcriptional regulator
AM457_05230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AM457_05240	COG0655	NAD(P)H dehydrogenase (quinone) activity
AM457_05275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AM457_05285	COG0477	Major facilitator Superfamily
AM457_05295	COG1253	flavin adenine dinucleotide binding
AM457_05305	COG2860	membrane
AM457_05310	COG0477	Major facilitator Superfamily
AM457_05320	COG0318	PFAM AMP-dependent synthetase and ligase
AM457_05335	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AM457_05350	COG3539	Fimbrial protein
AM457_05375	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM457_05375	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM457_05410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM457_05420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM457_05425	COG0606	chelatase, subunit chli
AM457_05460	COG0589	response to stress
AM457_05465	COG0659	secondary active sulfate transmembrane transporter activity
AM457_05475	COG0606	chelatase, subunit chli
AM457_05485	COG0347	Belongs to the P(II) protein family
AM457_05490	COG0004	ammonium transporteR
AM457_05500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM457_05500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AM457_05540	COG0795	lipopolysaccharide-transporting ATPase activity
AM457_05545	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AM457_05550	COG0793	Belongs to the peptidase S41A family
AM457_05565	COG2197	response regulator
AM457_05575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AM457_05585	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AM457_05590	COG4974	Belongs to the 'phage' integrase family
AM457_05615	COG0772	Belongs to the SEDS family
AM457_05620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AM457_05625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AM457_05630	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AM457_05655	COG0697	spore germination
AM457_05660	COG1538	Outer membrane efflux protein
AM457_05680	COG3275	phosphorelay sensor kinase activity
AM457_05690	COG0181	hydroxymethylbilane synthase activity
AM457_05735	COG1716	ATPase activity
AM457_05740	COG0546	phosphoglycolate phosphatase activity
AM457_05835	COG0596	Alpha beta hydrolase
AM457_05840	COG2056	Na+-H+ antiporter family
AM457_05855	COG0326	Molecular chaperone. Has ATPase activity
AM457_05870	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AM457_05935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AM457_05940	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM457_05940	COG2169	Transcriptional regulator
AM457_05970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AM457_05980	COG0497	DNA recombination
AM457_05995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM457_06005	COG0237	dephospho-CoA kinase activity
AM457_06055	COG0195	Participates in both transcription termination and antitermination
AM457_06075	COG2212	antiporter activity
AM457_06085	COG0651	ATP synthesis coupled electron transport
AM457_06090	COG1006	Multisubunit Na H antiporter MnhC subunit
AM457_06095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM457_06095	COG2111	Na H antiporter
AM457_06110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AM457_06130	COG2226	methyltransferase
AM457_06150	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AM457_06155	COG1074	ATP-dependent DNA helicase activity
AM457_06160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM457_06180	COG0598	Magnesium transport protein CorA
AM457_06185	COG0789	Transcriptional regulator
AM457_06190	COG0484	heat shock protein binding
AM457_06205	COG0475	glutathione-regulated potassium exporter activity
AM457_06205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM457_06210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AM457_06230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM457_06240	COG4535	Mg2 and Co2 transporter CorC
AM457_06245	COG0425	Belongs to the sulfur carrier protein TusA family
AM457_06250	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AM457_06250	COG0644	oxidoreductase
AM457_06260	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AM457_06275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM457_06280	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AM457_06315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AM457_06330	COG0534	Mate efflux family protein
AM457_06340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AM457_06345	COG4221	oxidoreductase activity
AM457_06350	COG0583	DNA-binding transcription factor activity
AM457_06370	COG1530	ribonuclease E activity
AM457_06385	COG0546	phosphoglycolate phosphatase activity
AM457_06390	COG2378	regulation of single-species biofilm formation
AM457_06395	COG0625	glutathione transferase activity
AM457_06405	COG0583	DNA-binding transcription factor activity
AM457_06435	COG0583	DNA-binding transcription factor activity
AM457_06460	COG0473	3-isopropylmalate dehydrogenase activity
AM457_06515	COG1301	dicarboxylic acid transport
AM457_06525	COG1560	Kdo2-lipid A biosynthetic process
AM457_06530	COG1280	lysine exporter protein (LysE YggA)
AM457_06575	COG0210	DNA helicase
AM457_06580	COG0724	RNA recognition motif
AM457_06600	COG4651	solute:proton antiporter activity
AM457_06600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM457_06605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AM457_06610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AM457_06625	COG0788	formyltetrahydrofolate deformylase activity
AM457_06730	COG2813	Specifically methylates the guanine in position
AM457_06730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM457_06740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AM457_06750	COG4774	siderophore transport
AM457_06760	COG0740	serine-type endopeptidase activity
AM457_06780	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AM457_06780	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AM457_06785	COG0857	belongs to the CobB CobQ family
AM457_06785	COG0280	phosphate acetyltransferase
AM457_06790	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AM457_06800	COG0800	Aldolase
AM457_06810	COG3265	gluconokinase activity
AM457_06815	COG1012	belongs to the aldehyde dehydrogenase family
AM457_06825	COG2267	carboxylic ester hydrolase activity
AM457_06840	COG0793	Belongs to the peptidase S41A family
AM457_06875	COG1426	Protein conserved in bacteria
AM457_06915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AM457_06925	COG1162	GTPase activity
AM457_06930	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AM457_06945	COG1538	Outer membrane efflux protein
AM457_06950	COG1136	(ABC) transporter
AM457_06950	COG0577	efflux transmembrane transporter activity
AM457_06955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM457_06980	COG0028	Belongs to the TPP enzyme family
AM457_06985	COG0440	acetolactate synthase activity
AM457_07025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AM457_07040	COG0084	hydrolase, TatD family'
AM457_07050	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AM457_07060	COG0583	DNA-binding transcription factor activity
AM457_07070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM457_07155	COG2205	protein histidine kinase activity
AM457_07170	COG2132	Multicopper oxidase
AM457_07195	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM457_07230	COG0640	Transcriptional regulator
AM457_07240	COG0798	PFAM Bile acid sodium symporter
AM457_07245	COG0431	NADPH-dependent FMN reductase
AM457_07250	COG0492	ferredoxin-NADP+ reductase activity
AM457_07255	COG2072	flavoprotein involved in K transport
AM457_07280	COG2814	Major facilitator Superfamily
AM457_07290	COG0697	spore germination
AM457_07295	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM457_07300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AM457_07305	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AM457_07320	COG3622	Belongs to the hyi family
AM457_07325	COG2084	Dehydrogenase
AM457_07330	COG1024	Enoyl-CoA hydratase
AM457_07335	COG5002	protein histidine kinase activity
AM457_07335	COG2205	protein histidine kinase activity
AM457_07335	COG0784	Response regulator, receiver
AM457_07355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AM457_07365	COG3956	TIGRFAM MazG family protein
AM457_07370	COG1555	photosystem II stabilization
AM457_07375	COG0617	tRNA 3'-terminal CCA addition
AM457_07380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AM457_07400	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM457_07405	COG3028	Belongs to the UPF0307 family
AM457_07410	COG0318	PFAM AMP-dependent synthetase and ligase
AM457_07425	COG0625	glutathione transferase activity
AM457_07430	COG1238	metal cluster binding
AM457_07445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AM457_07470	COG0072	phenylalanine-tRNA ligase activity
AM457_07500	COG0248	Ppx GppA phosphatase
AM457_07510	COG0037	tRNA processing
AM457_07550	COG1764	response to oxidative stress
AM457_07555	COG1846	Transcriptional regulator
AM457_07565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM457_07625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AM457_07630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AM457_07635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AM457_07645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AM457_07695	COG1214	PFAM Peptidase M22, glycoprotease
AM457_07710	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AM457_07720	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AM457_07725	COG0561	phosphatase activity
AM457_07750	COG3667	copper resistance
AM457_07765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AM457_07770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AM457_07775	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AM457_07805	COG1063	alcohol dehydrogenase
AM457_07810	COG0583	DNA-binding transcription factor activity
AM457_07815	COG1960	acyl-CoA dehydrogenase activity
AM457_07820	COG2814	Major facilitator Superfamily
AM457_07825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM457_07835	COG1053	succinate dehydrogenase
AM457_07840	COG0583	DNA-binding transcription factor activity
AM457_07860	COG0583	DNA-binding transcription factor activity
AM457_07870	COG1473	amidohydrolase
AM457_07890	COG0583	DNA-binding transcription factor activity
AM457_07900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AM457_07905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM457_07945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AM457_07960	COG0745	RESPONSE REGULATOR receiver
AM457_07965	COG2205	protein histidine kinase activity
AM457_08000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AM457_08030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AM457_08035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AM457_08055	COG0583	DNA-binding transcription factor activity
AM457_08075	COG0668	transmembrane transport
AM457_08085	COG2081	HI0933 family
AM457_08090	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AM457_08120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM457_08120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AM457_08130	COG0489	protein tyrosine kinase activity
AM457_08190	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AM457_08200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AM457_08215	COG0730	response to heat
AM457_08225	COG1196	nuclear chromosome segregation
AM457_08245	COG2223	nitrite transmembrane transporter activity
AM457_08250	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AM457_08255	COG1877	trehalose-phosphatase activity
AM457_08260	COG0596	Alpha beta hydrolase
AM457_08260	COG2226	methyltransferase
AM457_08260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM457_08275	COG4106	trans-aconitate 2-methyltransferase activity
AM457_08290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AM457_08295	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AM457_08300	COG0009	L-threonylcarbamoyladenylate synthase
AM457_08305	COG3101	peptidyl-lysine hydroxylation
AM457_08310	COG1399	metal-binding, possibly nucleic acid-binding protein
AM457_08335	COG1652	LysM domain
AM457_08340	COG0352	thiamine-phosphate diphosphorylase activity
AM457_08340	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AM457_08340	COG0351	phosphomethylpyrimidine kinase
AM457_08350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AM457_08380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM457_08410	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AM457_08425	COG0358	DNA primase activity
AM457_08435	COG0564	pseudouridine synthase activity
AM457_08460	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM457_08480	COG0583	DNA-binding transcription factor activity
AM457_08485	COG0473	3-isopropylmalate dehydrogenase activity
AM457_08505	COG1012	belongs to the aldehyde dehydrogenase family
AM457_08525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AM457_08525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AM457_08585	COG0456	acetyltransferase
AM457_08595	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AM457_08600	COG0492	ferredoxin-NADP+ reductase activity
AM457_08605	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AM457_08605	COG1674	ftsk spoiiie
AM457_08610	COG1280	lysine exporter protein (LysE YggA)
AM457_08625	COG2894	cell division
AM457_08640	COG0204	Acyl-transferase
AM457_08645	COG2885	chlorophyll binding
AM457_08650	COG0210	DNA helicase
AM457_08660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AM457_08675	COG0121	glutamine amidotransferase
AM457_08700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AM457_08705	COG0735	belongs to the Fur family
AM457_08730	COG0420	3'-5' exonuclease activity
AM457_08750	COG1090	epimerase
AM457_08765	COG2050	protein possibly involved in aromatic compounds catabolism
AM457_08775	COG2814	Major facilitator Superfamily
AM457_08780	COG0405	Gamma-glutamyltransferase
AM457_08790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AM457_08805	COG1401	restriction endodeoxyribonuclease activity
AM457_08835	COG0477	Major facilitator Superfamily
AM457_08840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM457_08850	COG1595	DNA-templated transcription, initiation
AM457_08905	COG0531	amino acid
AM457_08910	COG2040	homocysteine
AM457_08935	COG1309	transcriptional regulator
AM457_08940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM457_08945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AM457_08955	COG1607	acyl-coa hydrolase
AM457_08965	COG0523	cobalamin synthesis protein
AM457_08975	COG4681	YaeQ
AM457_08985	COG1649	PFAM Uncharacterised BCR, COG1649
AM457_08985	COG0726	polysaccharide deacetylase
AM457_08990	COG1215	transferase activity, transferring glycosyl groups
AM457_09000	COG1024	Enoyl-CoA hydratase
AM457_09015	COG1414	Transcriptional regulator
AM457_09035	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_09045	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM457_09050	COG2271	Major facilitator Superfamily
AM457_09060	COG2267	carboxylic ester hydrolase activity
AM457_09065	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_09080	COG0028	Belongs to the TPP enzyme family
AM457_09090	COG0477	Major facilitator Superfamily
AM457_09095	COG0242	peptide deformylase activity
AM457_09100	COG2066	Belongs to the glutaminase family
AM457_09105	COG2207	Transcriptional regulator
AM457_09110	COG2223	nitrite transmembrane transporter activity
AM457_09130	COG0583	DNA-binding transcription factor activity
AM457_09135	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_09140	COG2271	Major facilitator Superfamily
AM457_09145	COG3959	Transketolase, thiamine diphosphate binding domain
AM457_09150	COG3958	Transketolase
AM457_09165	COG0306	phosphate transporter
AM457_09190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AM457_09235	COG4181	ATPase activity
AM457_09240	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AM457_09270	COG0583	DNA-binding transcription factor activity
AM457_09280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM457_09285	COG1773	rubredoxin
AM457_09335	COG2851	Citrate transporter
AM457_09345	COG1253	flavin adenine dinucleotide binding
AM457_09385	COG0804	urea catabolic process
AM457_09395	COG0830	nickel cation binding
AM457_09410	COG0742	ribosomal rna small subunit methyltransferase
AM457_09415	COG0768	penicillin binding
AM457_09440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AM457_09445	COG2878	Part of a membrane complex involved in electron transport
AM457_09450	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AM457_09460	COG3384	dioxygenase
AM457_09485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AM457_09760	COG1598	PFAM Uncharacterised protein family UPF0150
AM457_09795	COG0739	heme binding
AM457_09850	COG2194	sulfuric ester hydrolase activity
AM457_09885	COG0006	proline dipeptidase activity
AM457_09890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM457_09895	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM457_09915	COG1279	arginine transmembrane transporter activity
AM457_09920	COG0583	DNA-binding transcription factor activity
AM457_09960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM457_09965	COG1388	LysM domain
AM457_09965	COG1388	LysM domain
AM457_09965	COG0741	lytic transglycosylase activity
AM457_09965	COG0741	lytic transglycosylase activity
AM457_09975	COG4174	ABC transporter (Permease)
AM457_09980	COG4239	(ABC) transporter, permease
AM457_09985	COG4172	Belongs to the ABC transporter superfamily
AM457_10040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AM457_10050	COG2203	Gaf domain
AM457_10050	COG3706	GGDEF domain
AM457_10050	COG4251	negative regulation of phosphorylation
AM457_10050	COG5001	Diguanylate cyclase
AM457_10060	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM457_10060	COG1902	pentaerythritol trinitrate reductase activity
AM457_10080	COG3501	Rhs element vgr protein
AM457_10085	COG3209	COG3209 Rhs family protein
AM457_10125	COG1113	amino acid transport
AM457_10135	COG0531	amino acid
AM457_10155	COG1012	belongs to the aldehyde dehydrogenase family
AM457_10175	COG3316	Transposase and inactivated derivatives
AM457_10190	COG1660	Displays ATPase and GTPase activities
AM457_10195	COG2746	aminoglycoside 3-N-acetyltransferase activity
AM457_10230	COG3316	Transposase and inactivated derivatives
AM457_10235	COG1741	Belongs to the pirin family
AM457_10250	COG2072	flavoprotein involved in K transport
AM457_10260	COG2252	PERMEase
AM457_10265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AM457_10270	COG3038	cytochrome b561
AM457_10280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AM457_10300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AM457_10315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AM457_10330	COG0667	Aldo Keto reductase
AM457_10350	COG1765	OsmC-like protein
AM457_10400	COG2885	chlorophyll binding
AM457_10410	COG0625	glutathione transferase activity
AM457_10415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AM457_10435	COG3634	alkyl hydroperoxide reductase activity
AM457_10445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AM457_10455	COG0450	alkyl hydroperoxide reductase
AM457_10460	COG1643	Atp-dependent helicase
AM457_10475	COG2814	Major facilitator Superfamily
AM457_10480	COG3135	benzoate transporter
AM457_10485	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_10490	COG0633	Ferredoxin
AM457_10490	COG0543	2 iron, 2 sulfur cluster binding
AM457_10495	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AM457_10500	COG4638	Rieske (2fe-2S)
AM457_10505	COG0583	DNA-binding transcription factor activity
AM457_10560	COG1570	exodeoxyribonuclease VII activity
AM457_10595	COG1280	lysine exporter protein (LysE YggA)
AM457_10600	COG1278	Cold shock
AM457_10640	COG2814	Major facilitator Superfamily
AM457_10645	COG1733	regulation of RNA biosynthetic process
AM457_10720	COG5410	chromosome segregation
AM457_10725	COG3567	Phage-associated protein, HI1409 family
AM457_10745	COG3566	protein conserved in bacteria
AM457_10765	COG5434	Belongs to the glycosyl hydrolase 28 family
AM457_10815	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AM457_10815	COG0517	IMP dehydrogenase activity
AM457_10820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AM457_10830	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AM457_10835	COG1137	ATPase activity
AM457_10880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AM457_10895	COG1522	sequence-specific DNA binding
AM457_10915	COG3316	Transposase and inactivated derivatives
AM457_10995	COG3316	Transposase and inactivated derivatives
AM457_11005	COG0235	Class ii aldolase
AM457_11010	COG3395	kinase activity
AM457_11015	COG2084	Dehydrogenase
AM457_11020	COG1349	DNA-binding transcription factor activity
AM457_11035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AM457_11040	COG3316	Transposase and inactivated derivatives
AM457_11055	COG2885	chlorophyll binding
AM457_11055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AM457_11100	COG0583	DNA-binding transcription factor activity
AM457_11110	COG0590	tRNA wobble adenosine to inosine editing
AM457_11115	COG2807	transmembrane transport
AM457_11130	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AM457_11140	COG0789	Transcriptional regulator
AM457_11155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AM457_11175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM457_11200	COG1012	belongs to the aldehyde dehydrogenase family
AM457_11205	COG0531	amino acid
AM457_11210	COG1760	l-serine dehydratase
AM457_11215	COG2030	dehydratase
AM457_11215	COG1012	belongs to the aldehyde dehydrogenase family
AM457_11220	COG3396	Phenylacetate-CoA oxygenase
AM457_11225	COG3460	Phenylacetate-CoA oxygenase
AM457_11230	COG3396	Phenylacetate-CoA oxygenase
AM457_11235	COG2151	metal-sulfur cluster biosynthetic enzyme
AM457_11240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM457_11245	COG1024	Enoyl-CoA hydratase
AM457_11250	COG1024	Enoyl-CoA hydratase
AM457_11255	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM457_11260	COG0183	Belongs to the thiolase family
AM457_11265	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AM457_11270	COG3327	negative regulation of DNA-templated transcription, initiation
AM457_11280	COG2050	protein possibly involved in aromatic compounds catabolism
AM457_11290	COG0556	nucleotide-excision repair
AM457_11330	COG1278	Cold shock
AM457_11340	COG2207	Transcriptional regulator
AM457_11350	COG3316	Transposase and inactivated derivatives
AM457_11370	COG3316	Transposase and inactivated derivatives
AM457_11380	COG3173	Aminoglycoside phosphotransferase
AM457_11385	COG3316	Transposase and inactivated derivatives
AM457_11420	COG2814	Major facilitator Superfamily
AM457_11435	COG0511	ligase activity, forming carbon-carbon bonds
AM457_11455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM457_11455	COG1116	anion transmembrane transporter activity
AM457_11460	COG0745	RESPONSE REGULATOR receiver
AM457_11470	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM457_11470	COG2146	nitrite reductase [NAD(P)H] activity
AM457_11475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AM457_11480	COG0243	molybdopterin cofactor binding
AM457_11490	COG0243	molybdopterin cofactor binding
AM457_11495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AM457_11510	COG0521	Mo-molybdopterin cofactor biosynthetic process
AM457_11510	COG0315	cyclic pyranopterin monophosphate synthase activity
AM457_11515	COG0303	'Molybdopterin
AM457_11525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM457_11530	COG0697	spore germination
AM457_11550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AM457_11555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AM457_11615	COG2204	response regulator
AM457_11620	COG3852	Histidine kinase
AM457_11645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AM457_11650	COG0575	Belongs to the CDS family
AM457_11685	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM457_11700	COG2137	regulation of response to DNA damage stimulus
AM457_11710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AM457_11715	COG1011	Hydrolase
AM457_11740	COG1522	sequence-specific DNA binding
AM457_11750	COG1113	amino acid transport
AM457_11765	COG0659	secondary active sulfate transmembrane transporter activity
AM457_11770	COG2135	peptidase activity
AM457_11785	COG3300	MHYT domain
AM457_11785	COG5001	Diguanylate cyclase
AM457_11800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM457_11800	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AM457_11800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AM457_11805	COG1105	Belongs to the carbohydrate kinase PfkB family
AM457_11810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AM457_11810	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AM457_11840	COG0024	Methionine aminopeptidase
AM457_11845	COG0583	DNA-binding transcription factor activity
AM457_11855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AM457_11860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AM457_11865	COG0516	GMP reductase activity
AM457_11865	COG0517	IMP dehydrogenase activity
AM457_11890	COG0552	protein localization to endoplasmic reticulum
AM457_11900	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AM457_11910	COG4890	Cyd operon protein YbgT
AM457_11915	COG1294	oxidase, subunit
AM457_11930	COG2826	transposase and inactivated derivatives, IS30 family
AM457_11935	COG1585	Membrane protein implicated in regulation of membrane protease activity
AM457_11945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AM457_11950	COG4774	siderophore transport
AM457_11965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AM457_11970	COG0569	domain protein
AM457_11975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AM457_12005	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AM457_12010	COG0542	response to heat
AM457_12020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM457_12035	COG1902	pentaerythritol trinitrate reductase activity
AM457_12035	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM457_12080	COG2323	membrane
AM457_12085	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AM457_12095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM457_12100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM457_12105	COG0183	Belongs to the thiolase family
AM457_12110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AM457_12115	COG0596	Alpha beta hydrolase
AM457_12120	COG2271	Major facilitator Superfamily
AM457_12125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AM457_12130	COG3485	protocatechuate 3,4-dioxygenase
AM457_12135	COG3485	protocatechuate 3,4-dioxygenase
AM457_12140	COG0710	3-dehydroquinate dehydratase activity
AM457_12145	COG3420	alginic acid biosynthetic process
AM457_12150	COG3659	wide pore channel activity
AM457_12155	COG4993	Dehydrogenase
AM457_12165	COG2391	methyltransferase activity
AM457_12180	COG1414	Transcriptional regulator
AM457_12185	COG0583	DNA-binding transcription factor activity
AM457_12190	COG1960	acyl-CoA dehydrogenase activity
AM457_12215	COG2814	Major facilitator Superfamily
AM457_12225	COG0154	amidase activity
AM457_12245	COG4638	Rieske (2fe-2S)
AM457_12255	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_12265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM457_12275	COG3733	amine oxidase
AM457_12285	COG1012	belongs to the aldehyde dehydrogenase family
AM457_12295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AM457_12300	COG0183	Belongs to the thiolase family
AM457_12305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM457_12310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM457_12320	COG4829	muconolactone delta-isomerase
AM457_12325	COG4948	Mandelate Racemase Muconate Lactonizing
AM457_12330	COG0583	DNA-binding transcription factor activity
AM457_12340	COG2186	Transcriptional regulator
AM457_12360	COG1012	belongs to the aldehyde dehydrogenase family
AM457_12375	COG0446	pyridine nucleotide-disulphide oxidoreductase
AM457_12375	COG1902	pentaerythritol trinitrate reductase activity
AM457_12415	COG1309	transcriptional regulator
AM457_12425	COG1335	isochorismatase
AM457_12430	COG0583	DNA-binding transcription factor activity
AM457_12440	COG0475	glutathione-regulated potassium exporter activity
AM457_12440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AM457_12450	COG1473	amidohydrolase
AM457_12545	COG0583	DNA-binding transcription factor activity
AM457_12570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AM457_12575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM457_12595	COG1566	PFAM secretion protein HlyD family protein
AM457_12610	COG1012	belongs to the aldehyde dehydrogenase family
AM457_12615	COG0129	dihydroxy-acid dehydratase activity
AM457_12625	COG0583	DNA-binding transcription factor activity
AM457_12630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AM457_12640	COG2084	Dehydrogenase
AM457_12645	COG2207	Transcriptional regulator
AM457_12650	COG1064	alcohol dehydrogenase
AM457_12660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM457_12665	COG1120	ATPase activity
AM457_12685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AM457_12750	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AM457_12850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM457_12865	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AM457_12880	COG2205	protein histidine kinase activity
AM457_12885	COG0745	RESPONSE REGULATOR receiver
AM457_12895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM457_12900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM457_12905	COG1538	Outer membrane efflux protein
AM457_12915	COG2072	flavoprotein involved in K transport
AM457_12935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AM457_12955	COG3539	Fimbrial protein
AM457_12980	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AM457_12990	COG0753	catalase activity
AM457_13005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AM457_13070	COG3433	isochorismatase activity
AM457_13070	COG1535	isochorismatase
AM457_13075	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_13080	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AM457_13085	COG4149	molybdate abc transporter
AM457_13090	COG0725	ABC transporter, periplasmic molybdate-binding protein
AM457_13100	COG4638	Rieske (2fe-2S)
AM457_13105	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AM457_13110	COG0543	2 iron, 2 sulfur cluster binding
AM457_13110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM457_13125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM457_13135	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_13140	COG0412	Dienelactone hydrolase
AM457_13150	COG2207	Transcriptional regulator
AM457_13155	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_13160	COG2610	gluconate transmembrane transporter activity
AM457_13180	COG0583	DNA-binding transcription factor activity
AM457_13195	COG2031	fatty acid transporter
AM457_13200	COG0183	Belongs to the thiolase family
AM457_13205	COG0583	DNA-binding transcription factor activity
AM457_13210	COG0583	DNA-binding transcription factor activity
AM457_13225	COG1027	Aspartate ammonia-lyase
AM457_13235	COG0477	Major facilitator Superfamily
AM457_13255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM457_13260	COG4521	taurine ABC transporter
AM457_13285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AM457_13290	COG1733	regulation of RNA biosynthetic process
AM457_13295	COG2207	Transcriptional regulator
AM457_13295	COG3708	Transcriptional regulator
AM457_13310	COG0730	response to heat
AM457_13320	COG3453	Protein conserved in bacteria
AM457_13320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM457_13330	COG3781	membrane
AM457_13335	COG1063	alcohol dehydrogenase
AM457_13345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM457_13350	COG0508	dehydrogenase complex catalyzes the overall conversion of
AM457_13355	COG0022	dehydrogenase e1 component
AM457_13360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AM457_13365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM457_13380	COG3706	GGDEF domain
AM457_13395	COG0133	tryptophan synthase activity
AM457_13405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AM457_13440	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AM457_13465	COG2226	methyltransferase
AM457_13520	COG0842	Transport permease protein
AM457_13525	COG0842	Transport permease protein
AM457_13530	COG1131	(ABC) transporter
AM457_13545	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM457_13550	COG4773	Receptor
AM457_13570	COG0730	response to heat
AM457_13575	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AM457_13590	COG0406	alpha-ribazole phosphatase activity
AM457_13645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM457_13655	COG4264	IucA IucC family
AM457_13660	COG4264	IucA IucC family
AM457_13665	COG2814	Major facilitator Superfamily
AM457_13680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AM457_13695	COG1960	acyl-CoA dehydrogenase activity
AM457_13700	COG1960	acyl-CoA dehydrogenase activity
AM457_13705	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AM457_13710	COG2207	Transcriptional regulator
AM457_13715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM457_13720	COG0776	regulation of translation
AM457_13745	COG0822	iron-sulfur transferase activity
AM457_13750	COG0316	Belongs to the HesB IscA family
AM457_13780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AM457_13800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AM457_13805	COG0702	epimerase
AM457_13840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AM457_13850	COG0339	signal peptide processing
AM457_13875	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
AM457_13900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AM457_13905	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AM457_13935	COG0776	regulation of translation
AM457_13955	COG0590	tRNA wobble adenosine to inosine editing
AM457_13985	COG2165	general secretion pathway protein
AM457_14000	COG0084	hydrolase, TatD family'
AM457_14020	COG1663	tetraacyldisaccharide 4'-kinase activity
AM457_14025	COG1132	(ABC) transporter
AM457_14035	COG0811	peptide transport
AM457_14040	COG1475	DNA binding
AM457_14045	COG1192	Involved in chromosome partitioning
AM457_14055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AM457_14070	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AM457_14075	COG0191	fructose-bisphosphate aldolase activity
AM457_14095	COG0424	maF-like protein
AM457_14100	COG2850	peptidyl-arginine hydroxylation
AM457_14110	COG0640	Transcriptional regulator
AM457_14120	COG3619	membrane
AM457_14125	COG3122	Protein conserved in bacteria
AM457_14130	COG1132	(ABC) transporter
AM457_14150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AM457_14155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AM457_14165	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM457_14165	COG0506	proline dehydrogenase activity
AM457_14165	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AM457_14170	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AM457_14185	COG3698	Phosphodiester glycosidase
AM457_14195	COG2353	YceI-like domain
AM457_14205	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AM457_14255	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AM457_14255	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AM457_14280	COG3539	Fimbrial protein
AM457_14290	COG3121	Chaperone
AM457_14320	COG0697	spore germination
AM457_14330	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AM457_14340	COG0583	DNA-binding transcription factor activity
AM457_14365	COG1309	transcriptional regulator
AM457_14380	COG1522	sequence-specific DNA binding
AM457_14390	COG1126	abc transporter atp-binding protein
AM457_14395	COG0765	amino acid transport
AM457_14400	COG0765	amino acid transport
AM457_14430	COG1464	Belongs to the NlpA lipoprotein family
AM457_14440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM457_14445	COG2011	ABC-type metal ion transport system permease component
AM457_14450	COG0012	GTP binding
AM457_14475	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AM457_14515	COG0386	Belongs to the glutathione peroxidase family
AM457_14525	COG0436	Aminotransferase
AM457_14530	COG1301	dicarboxylic acid transport
AM457_14565	COG3634	alkyl hydroperoxide reductase activity
AM457_14580	COG0583	DNA-binding transcription factor activity
AM457_14585	COG0798	PFAM Bile acid sodium symporter
AM457_14590	COG0640	Transcriptional regulator
AM457_14605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AM457_14615	COG0583	DNA-binding transcription factor activity
AM457_14625	COG1953	Uracil, thiamine, allantoin
AM457_14635	COG2175	clavaminate synthase activity
AM457_14640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM457_14645	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AM457_14650	COG4521	taurine ABC transporter
AM457_14660	COG0477	Major facilitator Superfamily
AM457_14685	COG1271	oxidase subunit
AM457_14690	COG1294	oxidase, subunit
AM457_14700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM457_14720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AM457_14740	COG3052	prosthetic group binding
AM457_14745	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AM457_14755	COG0583	DNA-binding transcription factor activity
AM457_14765	COG2814	Major facilitator Superfamily
AM457_14785	COG1346	cytolysis
AM457_14795	COG0583	DNA-binding transcription factor activity
AM457_14800	COG0625	glutathione transferase activity
AM457_14805	COG0625	glutathione transferase activity
AM457_14810	COG0583	DNA-binding transcription factor activity
AM457_14825	COG1045	serine acetyltransferase
AM457_14830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM457_14835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AM457_14840	COG1280	lysine exporter protein (LysE YggA)
AM457_14850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM457_14855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AM457_14860	COG1126	abc transporter atp-binding protein
AM457_14870	COG0765	amino acid transport
AM457_14890	COG0784	Response regulator, receiver
AM457_14890	COG2205	protein histidine kinase activity
AM457_14910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AM457_14935	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_14980	COG0583	DNA-binding transcription factor activity
AM457_15000	COG0318	PFAM AMP-dependent synthetase and ligase
AM457_15005	COG1309	transcriptional regulator
AM457_15010	COG1960	acyl-CoA dehydrogenase activity
AM457_15015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AM457_15020	COG1024	Enoyl-CoA hydratase
AM457_15035	COG0583	DNA-binding transcription factor activity
AM457_15050	COG1960	acyl-CoA dehydrogenase activity
AM457_15060	COG2814	Major facilitator Superfamily
AM457_15070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AM457_15075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AM457_15080	COG2814	Major facilitator Superfamily
AM457_15085	COG1960	acyl-CoA dehydrogenase activity
AM457_15090	COG1024	Enoyl-CoA hydratase
AM457_15095	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_15100	COG1250	3-hydroxyacyl-CoA dehydrogenase
AM457_15105	COG0183	Belongs to the thiolase family
AM457_15115	COG2814	Major facilitator Superfamily
AM457_15125	COG1024	Enoyl-CoA hydratase
AM457_15135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AM457_15140	COG1960	acyl-CoA dehydrogenase activity
AM457_15145	COG2814	Major facilitator Superfamily
AM457_15150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AM457_15155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AM457_15170	COG3842	ATPase activity
AM457_15175	COG1840	ABC-type Fe3 transport system, periplasmic component
AM457_15185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AM457_15190	COG1414	Transcriptional regulator
AM457_15200	COG0583	DNA-binding transcription factor activity
AM457_15210	COG3316	Transposase and inactivated derivatives
AM457_15245	COG0592	DNA-directed DNA polymerase activity
AM457_15285	COG2026	Addiction module toxin, RelE StbE family
AM457_15490	COG1484	DNA-dependent DNA replication
AM457_15615	COG0069	glutamate synthase activity
AM457_15635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AM457_15645	COG1454	alcohol dehydrogenase
AM457_15650	COG0824	Thioesterase
AM457_15660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AM457_15685	COG1028	Short-chain dehydrogenase reductase Sdr
AM457_15690	COG0183	Belongs to the thiolase family
AM457_15700	COG0583	DNA-binding transcription factor activity
AM457_15715	COG1522	sequence-specific DNA binding
AM457_15720	COG3135	benzoate transporter
AM457_15745	COG0589	response to stress
AM457_15750	COG0488	(ABC) transporter
AM457_15775	COG4773	Receptor
AM457_15805	COG0668	transmembrane transport
AM457_15815	COG1309	transcriptional regulator
AM457_15850	COG1605	Chorismate mutase
AM457_15890	COG0308	aminopeptidase N
AM457_15915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AM457_15920	COG1454	alcohol dehydrogenase
AM457_15940	COG0531	amino acid
AM457_15945	COG4303	Ethanolamine ammonia lyase large subunit
AM457_15950	COG4302	ethanolamine ammonia-lyase activity
AM457_15955	COG0519	Catalyzes the synthesis of GMP from XMP
AM457_15955	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AM457_15970	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AM457_15985	COG0697	spore germination
AM457_15990	COG1923	regulation of RNA biosynthetic process
AM457_16000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AM457_16005	COG0802	atpase or kinase
AM457_16025	COG1187	pseudouridine synthase activity
AM457_16040	COG0583	DNA-binding transcription factor activity
AM457_16130	COG4397	Mu-like prophage major head subunit gpT
AM457_16145	COG5005	Phage virion morphogenesis
AM457_16150	COG2369	cell adhesion
AM457_16155	COG4383	Mu-like prophage protein gp29
AM457_16165	COG4373	Mu-like prophage FluMu protein gp28
AM457_16230	COG3409	Peptidoglycan-binding domain 1 protein
AM457_16230	COG3267	Type II secretory pathway component ExeA
AM457_16255	COG0776	regulation of translation
AM457_16305	COG2814	Major facilitator Superfamily
AM457_16310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AM457_16340	COG0729	surface antigen
AM457_16360	COG0174	glutamine synthetase
AM457_16365	COG0745	RESPONSE REGULATOR receiver
AM457_16370	COG2205	protein histidine kinase activity
AM457_16380	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AM457_16385	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AM457_16410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AM457_16415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AM457_16420	COG1960	acyl-CoA dehydrogenase activity
AM457_16435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AM457_16440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AM457_16460	COG0583	DNA-binding transcription factor activity
AM457_16480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AM457_16490	COG3658	cytochrome
AM457_16495	COG1215	transferase activity, transferring glycosyl groups
AM457_16500	COG0726	polysaccharide deacetylase
AM457_16500	COG1649	PFAM Uncharacterised BCR, COG1649
AM457_16525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AM457_16530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AM457_16540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AM457_16565	COG0305	Participates in initiation and elongation during chromosome replication
AM457_16570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AM457_16580	COG1305	Transglutaminase-like
AM457_16590	COG2308	Evidence 4 Homologs of previously reported genes of
AM457_16625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AM457_16630	COG0138	bifunctional purine biosynthesis protein purh
AM457_16635	COG0151	Belongs to the GarS family
AM457_16640	COG1464	Belongs to the NlpA lipoprotein family
AM457_16645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AM457_16650	COG2011	ABC-type metal ion transport system permease component
AM457_16655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AM457_16665	COG1301	dicarboxylic acid transport
AM457_16695	COG1794	racemase activity, acting on amino acids and derivatives
AM457_16700	COG3118	belongs to the thioredoxin family
AM457_16700	COG0492	ferredoxin-NADP+ reductase activity
AM457_16715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AM457_16715	COG3008	intermembrane lipid transfer
AM457_16720	COG2995	paraquat-inducible protein a
AM457_16745	COG0477	Major facilitator Superfamily
AM457_16805	COG2186	Transcriptional regulator
AM457_16815	COG0786	glutamate:sodium symporter activity
AM457_16820	COG3243	poly(R)-hydroxyalkanoic acid synthase
AM457_16845	COG3111	PFAM Bacterial OB fold (BOF) protein
AM457_16905	COG2815	serine threonine protein kinase
AM457_16905	COG0515	serine threonine protein kinase
AM457_16930	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AM457_16935	COG1610	YqeY-like protein
AM457_16940	COG4783	chaperone-mediated protein folding
AM457_16965	COG1286	toxin biosynthetic process
AM457_16995	COG0778	Nitroreductase
AM457_17005	COG0513	Belongs to the DEAD box helicase family
AM457_17025	COG2363	Small membrane protein
AM457_17050	COG1234	tRNA 3'-trailer cleavage
AM457_17055	COG2195	Cleaves the N-terminal amino acid of tripeptides
AM457_17065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AM457_17075	COG2819	hydrolase of the alpha beta superfamily
AM457_17080	COG1960	acyl-CoA dehydrogenase activity
AM457_17085	COG1301	dicarboxylic acid transport
AM457_17100	COG3139	Protein of unknown function (DUF1315)
AM457_17105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AM457_17110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AM457_17120	COG0494	nUDIX hydrolase
AM457_17130	COG0642	Histidine kinase
AM457_17135	COG0745	RESPONSE REGULATOR receiver
AM457_17155	COG1720	tRNA m6t6A37 methyltransferase activity
AM457_17170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AM457_17180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AM457_17190	COG4598	ABC transporter
AM457_17195	COG4160	amino acid transport
AM457_17200	COG4215	(ABC) transporter
AM457_17220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AM457_17230	COG1538	Outer membrane efflux protein
AM457_17265	COG1131	(ABC) transporter
AM457_17270	COG0842	Transport permease protein
AM457_17285	COG0772	Belongs to the SEDS family
AM457_17290	COG2951	lytic endotransglycosylase activity
AM457_17315	COG2207	Transcriptional regulator
AM457_17330	COG0052	Belongs to the universal ribosomal protein uS2 family
AM457_17335	COG0024	Methionine aminopeptidase
AM457_17345	COG2223	nitrite transmembrane transporter activity
AM457_17355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AM457_17360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AM457_17365	COG1960	acyl-CoA dehydrogenase activity
AM457_17380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AM457_17385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AM457_17390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AM457_17410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM457_17415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AM457_17420	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AM457_17455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AM457_17470	COG3104	oligopeptide transport
AM457_17480	COG0512	Glutamine amidotransferase of anthranilate synthase
AM457_17485	COG0308	aminopeptidase N
AM457_17515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AM457_17550	COG3739	integral membrane protein
AM457_17565	COG1169	isochorismate synthase
AM457_17575	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AM457_17585	COG1132	(ABC) transporter
AM457_17600	COG1535	isochorismatase
AM457_17600	COG3433	isochorismatase activity
AM457_17605	COG1021	2,3-dihydroxybenzoate-AMP ligase
AM457_17610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM457_17620	COG4774	siderophore transport
AM457_17625	COG4607	ABC-type enterochelin transport system periplasmic component
AM457_17630	COG4604	ABC transporter, ATP-binding protein
AM457_17635	COG4605	iron ion homeostasis
AM457_17640	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AM457_17645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AM457_17660	COG2964	Protein conserved in bacteria
AM457_17670	COG1741	Belongs to the pirin family
AM457_17690	COG2879	small protein
AM457_17695	COG1966	Carbon starvation protein
AM457_17740	COG1067	ATP-dependent peptidase activity
AM457_17745	COG0583	DNA-binding transcription factor activity
AM457_17770	COG1686	Belongs to the peptidase S11 family
AM457_17775	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AM457_17810	COG0616	signal peptide processing
AM457_17815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AM457_17825	COG0573	inorganic phosphate transmembrane transporter activity
AM457_17830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AM457_17835	COG1113	amino acid transport
AM457_17840	COG3961	Belongs to the TPP enzyme family
AM457_17845	COG1522	sequence-specific DNA binding
AM457_17855	COG0076	glutamate decarboxylase activity
AM457_17860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AM457_17870	COG1309	transcriptional regulator
AM457_17885	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AM457_17920	COG0352	thiamine-phosphate diphosphorylase activity
AM457_17945	COG0612	Peptidase, M16
AM457_17960	COG0583	DNA-binding transcription factor activity
AM457_17965	COG0477	Major facilitator Superfamily
AM457_17990	COG1187	pseudouridine synthase activity
AM457_18005	COG1686	Belongs to the peptidase S11 family
AM457_18010	COG1252	NADH dehydrogenase
AM457_18020	COG0415	Belongs to the DNA photolyase family
AM457_18035	COG1215	transferase activity, transferring glycosyl groups
AM457_18065	COG2070	2-Nitropropane dioxygenase
AM457_18120	COG0556	nucleotide-excision repair
AM457_18170	COG4221	oxidoreductase activity
AM457_18180	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AM457_18185	COG1381	Involved in DNA repair and RecF pathway recombination
AM457_18195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AM457_18210	COG0681	Belongs to the peptidase S26 family
AM457_18220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AM457_18230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AM457_18250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AM457_18255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AM457_18260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AM457_18270	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AM457_18275	COG4208	sulfate ABC transporter
AM457_18280	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AM457_18285	COG0583	DNA-binding transcription factor activity
AM457_18290	COG4625	pathogenesis
AM457_18305	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AM457_18320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AM457_18330	COG1051	belongs to the nudix hydrolase family
AM457_18330	COG1056	cytidyltransferase-related domain
AM457_18335	COG1024	Enoyl-CoA hydratase
AM457_18340	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AM457_18360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AM457_18360	COG0047	phosphoribosylformylglycinamidine synthase activity
AM457_18380	COG1473	amidohydrolase
AM457_18385	COG0824	Thioesterase
AM457_18405	COG0823	Involved in the tonB-independent uptake of proteins
AM457_18425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AM457_18460	COG0628	permease
AM457_18470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AM457_18475	COG0596	Alpha beta hydrolase
AM457_18480	COG0616	signal peptide processing
AM457_18480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AM457_18490	COG0658	competence protein
AM457_18490	COG2333	competence protein COMEC
AM457_18495	COG1136	(ABC) transporter
AM457_18500	COG4591	ABC-type transport system involved in lipoprotein release permease component