locus-tag	class	description
I5593_00010	COG0592	DNA-directed DNA polymerase activity
I5593_00020	COG0187	DNA topoisomerase II activity
I5593_00030	COG0586	Pfam SNARE associated Golgi protein
I5593_00035	COG0488	(ABC) transporter
I5593_00060	COG0596	Alpha beta hydrolase
I5593_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
I5593_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5593_00100	COG0625	glutathione transferase activity
I5593_00110	COG0733	neurotransmitter:sodium symporter activity
I5593_00145	COG0583	DNA-binding transcription factor activity
I5593_00150	COG2233	PERMEase
I5593_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5593_00200	COG2814	Major facilitator Superfamily
I5593_00205	COG0656	L-ascorbic acid biosynthetic process
I5593_00210	COG0583	DNA-binding transcription factor activity
I5593_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5593_00230	COG1064	alcohol dehydrogenase
I5593_00235	COG2818	Glycosylase
I5593_00250	COG1194	a g-specific adenine glycosylase
I5593_00270	COG2983	Belongs to the UPF0260 family
I5593_00275	COG2133	pyrroloquinoline quinone binding
I5593_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5593_00285	COG2116	formate transmembrane transporter activity
I5593_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5593_00310	COG1335	isochorismatase
I5593_00315	COG0385	Bile acid
I5593_00325	COG1683	Conserved Protein
I5593_00345	COG0625	glutathione transferase activity
I5593_00355	COG1113	amino acid transport
I5593_00365	COG0523	cobalamin synthesis protein
I5593_00375	COG2188	Transcriptional regulator
I5593_00405	COG0010	Belongs to the arginase family
I5593_00415	COG0546	phosphoglycolate phosphatase activity
I5593_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5593_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5593_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5593_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I5593_00535	COG0534	Mate efflux family protein
I5593_00540	COG0436	Aminotransferase
I5593_00545	COG2733	membrane
I5593_00560	COG2918	glutathione biosynthetic process
I5593_00595	COG3150	esterase
I5593_00605	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_00610	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I5593_00620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5593_00630	COG2233	PERMEase
I5593_00635	COG2351	hydroxyisourate hydrolase activity
I5593_00670	COG3706	GGDEF domain
I5593_00685	COG1393	Belongs to the ArsC family
I5593_00690	COG0708	Exodeoxyribonuclease III
I5593_00710	COG0189	ligase activity
I5593_00730	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I5593_00740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5593_00755	COG4942	peptidase
I5593_00765	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5593_00775	COG2119	membrane
I5593_00780	COG4774	siderophore transport
I5593_00785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5593_00785	COG0426	domain, Protein
I5593_00810	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5593_00830	COG1902	pentaerythritol trinitrate reductase activity
I5593_00835	COG1519	Transferase
I5593_00840	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5593_00845	COG0668	transmembrane transport
I5593_00855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5593_00860	COG1335	isochorismatase
I5593_00865	COG1522	sequence-specific DNA binding
I5593_00890	COG2205	protein histidine kinase activity
I5593_00890	COG0784	Response regulator, receiver
I5593_00890	COG2198	Histidine kinase
I5593_00895	COG3162	membrane
I5593_00900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5593_00910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5593_00930	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5593_00935	COG1309	transcriptional regulator
I5593_00955	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5593_00955	COG0352	thiamine-phosphate diphosphorylase activity
I5593_00955	COG0351	phosphomethylpyrimidine kinase
I5593_00965	COG2814	Major facilitator Superfamily
I5593_00980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I5593_00990	COG1113	amino acid transport
I5593_01000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5593_01005	COG1012	belongs to the aldehyde dehydrogenase family
I5593_01015	COG1335	isochorismatase
I5593_01045	COG2814	Major facilitator Superfamily
I5593_01050	COG0583	DNA-binding transcription factor activity
I5593_01070	COG0667	Aldo Keto reductase
I5593_01095	COG1733	regulation of RNA biosynthetic process
I5593_01100	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5593_01165	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5593_01205	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5593_01235	COG0427	acetyl-CoA hydrolase
I5593_01260	COG0659	secondary active sulfate transmembrane transporter activity
I5593_01265	COG4221	oxidoreductase activity
I5593_01270	COG2873	o-acetylhomoserine
I5593_01275	COG0488	(ABC) transporter
I5593_01360	COG0833	amino acid
I5593_01405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I5593_01410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5593_01425	COG2226	methyltransferase
I5593_01475	COG0069	glutamate synthase activity
I5593_01475	COG0067	glutamate synthase
I5593_01475	COG0070	glutamate synthase
I5593_01480	COG0493	'glutamate synthase
I5593_01490	COG1704	LemA family
I5593_01495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I5593_01515	COG3307	-O-antigen
I5593_01535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5593_01550	COG0194	GDP metabolic process
I5593_01600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I5593_01620	COG5380	lipid catabolic process
I5593_01625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5593_01650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5593_01655	COG0277	FAD linked oxidase domain protein
I5593_01665	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I5593_01670	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5593_01685	COG1289	transmembrane transporter activity
I5593_01695	COG0628	permease
I5593_01700	COG1192	Involved in chromosome partitioning
I5593_01730	COG0833	amino acid
I5593_01735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5593_01740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5593_01750	COG1012	belongs to the aldehyde dehydrogenase family
I5593_01790	COG0583	DNA-binding transcription factor activity
I5593_01845	COG0517	IMP dehydrogenase activity
I5593_01850	COG1983	PspC domain protein
I5593_01860	COG1960	acyl-CoA dehydrogenase activity
I5593_01875	COG0408	coproporphyrinogen oxidase activity
I5593_01895	COG0513	Belongs to the DEAD box helicase family
I5593_01905	COG1127	ABC transporter
I5593_01910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I5593_01920	COG2854	intermembrane phospholipid transfer
I5593_01930	COG0598	Magnesium transport protein CorA
I5593_01940	COG0494	nUDIX hydrolase
I5593_01945	COG1040	competence protein
I5593_01950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5593_01970	COG1946	Acyl-CoA thioesterase
I5593_01975	COG1301	dicarboxylic acid transport
I5593_01990	COG1959	2 iron, 2 sulfur cluster binding
I5593_01995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5593_01995	COG1017	nitric oxide dioxygenase activity
I5593_02005	COG0433	COG0433 Predicted ATPase
I5593_02010	COG0626	cystathionine gamma-synthase activity
I5593_02165	COG1960	acyl-CoA dehydrogenase activity
I5593_02170	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I5593_02200	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I5593_02205	COG0339	signal peptide processing
I5593_02210	COG0557	exoribonuclease II activity
I5593_02255	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5593_02260	COG2169	Transcriptional regulator
I5593_02265	COG0697	spore germination
I5593_02270	COG1295	ribonuclease BN
I5593_02305	COG1702	phosphate starvation-inducible protein PhoH
I5593_02315	COG1196	nuclear chromosome segregation
I5593_02315	COG0741	lytic transglycosylase activity
I5593_02315	COG0739	heme binding
I5593_02345	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I5593_02350	COG1183	phosphatidylcholine synthase activity
I5593_02395	COG1960	acyl-CoA dehydrogenase activity
I5593_02400	COG1309	transcriptional regulator
I5593_02415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5593_02420	COG1960	acyl-CoA dehydrogenase activity
I5593_02460	COG2969	positive regulation of protein catabolic process
I5593_02470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I5593_02480	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I5593_02485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5593_02490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I5593_02510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5593_02520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5593_02525	COG1408	metallophosphoesterase
I5593_02535	COG2199	diguanylate cyclase activity
I5593_02595	COG1607	acyl-coa hydrolase
I5593_02625	COG2350	Protein conserved in bacteria
I5593_02635	COG0613	PHP domain protein
I5593_02640	COG3781	membrane
I5593_02650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5593_02655	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5593_02665	COG1862	Preprotein translocase
I5593_02695	COG2205	protein histidine kinase activity
I5593_02700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I5593_02715	COG0726	polysaccharide deacetylase
I5593_02720	COG0438	transferase activity, transferring glycosyl groups
I5593_02735	COG1091	dTDP-4-dehydrorhamnose reductase activity
I5593_02750	COG1215	transferase activity, transferring glycosyl groups
I5593_02800	COG1960	acyl-CoA dehydrogenase activity
I5593_02805	COG1960	acyl-CoA dehydrogenase activity
I5593_02815	COG2205	protein histidine kinase activity
I5593_02820	COG0745	RESPONSE REGULATOR receiver
I5593_02825	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I5593_02845	COG2096	Adenosyltransferase
I5593_02850	COG4206	TonB-dependent receptor
I5593_02895	COG0285	dihydrofolate synthase activity
I5593_02915	COG0450	alkyl hydroperoxide reductase
I5593_02930	COG0477	Major facilitator Superfamily
I5593_02935	COG1272	protein, Hemolysin III
I5593_02965	COG0183	Belongs to the thiolase family
I5593_02970	COG2207	Transcriptional regulator
I5593_02990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5593_03010	COG0183	Belongs to the thiolase family
I5593_03020	COG2885	chlorophyll binding
I5593_03020	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I5593_03030	COG1690	Belongs to the RtcB family
I5593_03035	COG0833	amino acid
I5593_03045	COG2233	PERMEase
I5593_03050	COG1217	gtp-binding protein TYPA
I5593_03075	COG2094	Belongs to the DNA glycosylase MPG family
I5593_03080	COG4772	TonB-dependent receptor
I5593_03085	COG1902	pentaerythritol trinitrate reductase activity
I5593_03090	COG0679	Auxin Efflux Carrier
I5593_03100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5593_03105	COG0354	folic acid binding
I5593_03115	COG3189	MarR family transcriptional regulator
I5593_03120	COG2824	Alkylphosphonate utilization operon protein PhnA
I5593_03125	COG3422	double-strand break repair
I5593_03165	COG0840	transmembrane signaling receptor activity
I5593_03180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5593_03195	COG5510	response to toxic substance
I5593_03205	COG2832	Protein of unknown function (DUF454)
I5593_03210	COG1376	ErfK ybiS ycfS ynhG family protein
I5593_03250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I5593_03260	COG1289	transmembrane transporter activity
I5593_03265	COG2814	Major facilitator Superfamily
I5593_03285	COG1115	amino acid carrier protein
I5593_03290	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5593_03295	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5593_03300	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I5593_03325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5593_03335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5593_03340	COG1077	Cell shape determining protein MreB Mrl
I5593_03345	COG1792	Involved in formation and maintenance of cell shape
I5593_03350	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5593_03355	COG0424	maF-like protein
I5593_03360	COG1530	ribonuclease E activity
I5593_03370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5593_03380	COG0560	Phosphoserine phosphatase
I5593_03390	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5593_03415	COG2207	Transcriptional regulator
I5593_03435	COG1113	amino acid transport
I5593_03440	COG2828	Protein conserved in bacteria
I5593_03445	COG0142	geranyltranstransferase activity
I5593_03450	COG2315	Protein conserved in bacteria
I5593_03465	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5593_03485	COG2194	sulfuric ester hydrolase activity
I5593_03490	COG0745	RESPONSE REGULATOR receiver
I5593_03495	COG0642	Histidine kinase
I5593_03510	COG0004	ammonium transporteR
I5593_03515	COG0583	DNA-binding transcription factor activity
I5593_03535	COG0525	valine-tRNA ligase activity
I5593_03545	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_03555	COG0393	Putative heavy-metal-binding
I5593_03560	COG0393	Putative heavy-metal-binding
I5593_03565	COG1538	Outer membrane efflux protein
I5593_03575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5593_03580	COG0671	phosphoesterase, PA-phosphatase related
I5593_03610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I5593_03625	COG1648	precorrin-2 dehydrogenase activity
I5593_03625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I5593_03630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5593_03645	COG0531	amino acid
I5593_03660	COG0321	lipoyl(octanoyl) transferase activity
I5593_03665	COG2921	Belongs to the UPF0250 family
I5593_03700	COG2009	succinate dehydrogenase
I5593_03705	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I5593_03710	COG1053	succinate dehydrogenase
I5593_03715	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5593_03740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5593_03760	COG2354	Protein conserved in bacteria
I5593_03765	COG2321	neutral zinc metallopeptidase
I5593_03790	COG2843	Capsule synthesis protein
I5593_03805	COG0589	response to stress
I5593_03825	COG0505	Belongs to the CarA family
I5593_03850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5593_03855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5593_03905	COG0477	Major facilitator Superfamily
I5593_03910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5593_03925	COG1597	lipid kinase activity
I5593_03930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5593_03955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5593_03960	COG0584	glycerophosphoryl diester phosphodiesterase
I5593_03980	COG0741	lytic transglycosylase activity
I5593_04000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5593_04015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5593_04040	COG0778	Nitroreductase
I5593_04055	COG1929	Belongs to the glycerate kinase type-1 family
I5593_04060	COG0243	molybdopterin cofactor binding
I5593_04065	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5593_04070	COG3339	Conserved Protein
I5593_04080	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
I5593_04095	COG1113	amino acid transport
I5593_04105	COG0019	diaminopimelate decarboxylase activity
I5593_04120	COG2267	carboxylic ester hydrolase activity
I5593_04125	COG1280	lysine exporter protein (LysE YggA)
I5593_04130	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I5593_04160	COG0463	Glycosyl transferase, family 2
I5593_04180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5593_04215	COG4591	ABC-type transport system involved in lipoprotein release permease component
I5593_04220	COG1136	(ABC) transporter
I5593_04225	COG0658	competence protein
I5593_04225	COG2333	competence protein COMEC
I5593_04235	COG0616	signal peptide processing
I5593_04235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I5593_04240	COG0596	Alpha beta hydrolase
I5593_04245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5593_04255	COG0628	permease
I5593_04290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5593_04310	COG0823	Involved in the tonB-independent uptake of proteins
I5593_04330	COG0824	Thioesterase
I5593_04335	COG1473	amidohydrolase
I5593_04355	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5593_04355	COG0047	phosphoribosylformylglycinamidine synthase activity
I5593_04360	COG2814	Major facilitator Superfamily
I5593_04370	COG1024	Enoyl-CoA hydratase
I5593_04375	COG1056	cytidyltransferase-related domain
I5593_04375	COG1051	belongs to the nudix hydrolase family
I5593_04385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5593_04400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I5593_04415	COG4625	pathogenesis
I5593_04420	COG0583	DNA-binding transcription factor activity
I5593_04425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I5593_04430	COG4208	sulfate ABC transporter
I5593_04435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I5593_04445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I5593_04450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5593_04455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5593_04475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5593_04490	COG0681	Belongs to the peptidase S26 family
I5593_04505	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I5593_04515	COG1381	Involved in DNA repair and RecF pathway recombination
I5593_04520	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I5593_04530	COG4221	oxidoreductase activity
I5593_04560	COG0443	Heat shock 70 kDa protein
I5593_04570	COG0436	Aminotransferase
I5593_04590	COG0556	nucleotide-excision repair
I5593_04645	COG2070	2-Nitropropane dioxygenase
I5593_04675	COG1215	transferase activity, transferring glycosyl groups
I5593_04690	COG0415	Belongs to the DNA photolyase family
I5593_04700	COG1252	NADH dehydrogenase
I5593_04705	COG1686	Belongs to the peptidase S11 family
I5593_04720	COG1187	pseudouridine synthase activity
I5593_04745	COG0477	Major facilitator Superfamily
I5593_04750	COG0583	DNA-binding transcription factor activity
I5593_04755	COG1823	symporter activity
I5593_04765	COG0612	Peptidase, M16
I5593_04790	COG0352	thiamine-phosphate diphosphorylase activity
I5593_04825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5593_04835	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5593_04850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I5593_04855	COG0076	glutamate decarboxylase activity
I5593_04865	COG1522	sequence-specific DNA binding
I5593_04870	COG3961	Belongs to the TPP enzyme family
I5593_04875	COG1113	amino acid transport
I5593_04880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5593_04885	COG0573	inorganic phosphate transmembrane transporter activity
I5593_04895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5593_04900	COG0616	signal peptide processing
I5593_04935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5593_04940	COG1686	Belongs to the peptidase S11 family
I5593_04965	COG0583	DNA-binding transcription factor activity
I5593_04970	COG1067	ATP-dependent peptidase activity
I5593_04995	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I5593_05015	COG1966	Carbon starvation protein
I5593_05020	COG2879	small protein
I5593_05050	COG1741	Belongs to the pirin family
I5593_05060	COG2964	Protein conserved in bacteria
I5593_05075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5593_05080	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5593_05085	COG4605	iron ion homeostasis
I5593_05090	COG4604	ABC transporter, ATP-binding protein
I5593_05095	COG4607	ABC-type enterochelin transport system periplasmic component
I5593_05100	COG4774	siderophore transport
I5593_05110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I5593_05115	COG1021	2,3-dihydroxybenzoate-AMP ligase
I5593_05120	COG1535	isochorismatase
I5593_05120	COG3433	isochorismatase activity
I5593_05130	COG1132	(ABC) transporter
I5593_05135	COG1132	(ABC) transporter
I5593_05140	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I5593_05150	COG1169	isochorismate synthase
I5593_05165	COG3739	integral membrane protein
I5593_05185	COG0302	gtp cyclohydrolase
I5593_05195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I5593_05225	COG0308	aminopeptidase N
I5593_05230	COG0512	Glutamine amidotransferase of anthranilate synthase
I5593_05245	COG0174	glutamine synthetase
I5593_05255	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I5593_05290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5593_05295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I5593_05300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5593_05320	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5593_05325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5593_05330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I5593_05345	COG1960	acyl-CoA dehydrogenase activity
I5593_05350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I5593_05355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5593_05365	COG2223	nitrite transmembrane transporter activity
I5593_05375	COG0024	Methionine aminopeptidase
I5593_05380	COG0052	Belongs to the universal ribosomal protein uS2 family
I5593_05395	COG2207	Transcriptional regulator
I5593_05420	COG2951	lytic endotransglycosylase activity
I5593_05425	COG0772	Belongs to the SEDS family
I5593_05440	COG0842	Transport permease protein
I5593_05445	COG1131	(ABC) transporter
I5593_05450	COG0582	viral genome integration into host DNA
I5593_05455	COG3617	BRO family, N-terminal domain
I5593_05840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5593_05855	COG4215	(ABC) transporter
I5593_05860	COG4160	amino acid transport
I5593_05865	COG4598	ABC transporter
I5593_05875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5593_05880	COG0826	peptidase U32
I5593_05885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5593_05900	COG1720	tRNA m6t6A37 methyltransferase activity
I5593_05910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5593_05915	COG3111	PFAM Bacterial OB fold (BOF) protein
I5593_05925	COG0642	Histidine kinase
I5593_05935	COG0494	nUDIX hydrolase
I5593_05945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5593_05950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I5593_05955	COG3139	Protein of unknown function (DUF1315)
I5593_05960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5593_05965	COG1301	dicarboxylic acid transport
I5593_05970	COG1960	acyl-CoA dehydrogenase activity
I5593_05975	COG2819	hydrolase of the alpha beta superfamily
I5593_05985	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5593_05995	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5593_06000	COG1234	tRNA 3'-trailer cleavage
I5593_06030	COG2363	Small membrane protein
I5593_06050	COG0513	Belongs to the DEAD box helicase family
I5593_06060	COG0778	Nitroreductase
I5593_06090	COG1286	toxin biosynthetic process
I5593_06115	COG4783	chaperone-mediated protein folding
I5593_06120	COG1610	YqeY-like protein
I5593_06220	COG3111	PFAM Bacterial OB fold (BOF) protein
I5593_06245	COG3243	poly(R)-hydroxyalkanoic acid synthase
I5593_06250	COG0786	glutamate:sodium symporter activity
I5593_06260	COG2186	Transcriptional regulator
I5593_06310	COG0477	Major facilitator Superfamily
I5593_06315	COG1051	belongs to the nudix hydrolase family
I5593_06345	COG2995	paraquat-inducible protein a
I5593_06350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I5593_06350	COG3008	intermembrane lipid transfer
I5593_06360	COG2351	hydroxyisourate hydrolase activity
I5593_06400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5593_06410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I5593_06415	COG0642	Histidine kinase
I5593_06420	COG0745	RESPONSE REGULATOR receiver
I5593_06440	COG1794	racemase activity, acting on amino acids and derivatives
I5593_06470	COG1301	dicarboxylic acid transport
I5593_06480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5593_06485	COG2011	ABC-type metal ion transport system permease component
I5593_06490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5593_06495	COG1464	Belongs to the NlpA lipoprotein family
I5593_06500	COG0151	Belongs to the GarS family
I5593_06505	COG0138	bifunctional purine biosynthesis protein purh
I5593_06510	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I5593_06540	COG2308	Evidence 4 Homologs of previously reported genes of
I5593_06550	COG1305	Transglutaminase-like
I5593_06560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I5593_06565	COG0305	Participates in initiation and elongation during chromosome replication
I5593_06590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5593_06600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5593_06605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5593_06630	COG1649	PFAM Uncharacterised BCR, COG1649
I5593_06630	COG0726	polysaccharide deacetylase
I5593_06635	COG1215	transferase activity, transferring glycosyl groups
I5593_06640	COG3658	cytochrome
I5593_06650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5593_06665	COG0583	DNA-binding transcription factor activity
I5593_06695	COG1960	acyl-CoA dehydrogenase activity
I5593_06700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5593_06705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5593_06730	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I5593_06735	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I5593_06745	COG2205	protein histidine kinase activity
I5593_06750	COG0745	RESPONSE REGULATOR receiver
I5593_06755	COG0174	glutamine synthetase
I5593_06775	COG0729	surface antigen
I5593_06800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5593_06805	COG2814	Major facilitator Superfamily
I5593_06820	COG0583	DNA-binding transcription factor activity
I5593_06835	COG1187	pseudouridine synthase activity
I5593_06855	COG0802	atpase or kinase
I5593_06860	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5593_06870	COG1923	regulation of RNA biosynthetic process
I5593_06875	COG0697	spore germination
I5593_06890	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5593_06900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5593_06905	COG0519	Catalyzes the synthesis of GMP from XMP
I5593_06905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5593_06910	COG4302	ethanolamine ammonia-lyase activity
I5593_06915	COG4303	Ethanolamine ammonia lyase large subunit
I5593_06920	COG0531	amino acid
I5593_06940	COG1454	alcohol dehydrogenase
I5593_06945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5593_06970	COG0308	aminopeptidase N
I5593_07010	COG1605	Chorismate mutase
I5593_07025	COG1309	transcriptional regulator
I5593_07035	COG0668	transmembrane transport
I5593_07065	COG4773	Receptor
I5593_07085	COG0488	(ABC) transporter
I5593_07090	COG0589	response to stress
I5593_07115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I5593_07125	COG3135	benzoate transporter
I5593_07130	COG1522	sequence-specific DNA binding
I5593_07140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5593_07145	COG0583	DNA-binding transcription factor activity
I5593_07155	COG0183	Belongs to the thiolase family
I5593_07165	COG2030	dehydratase
I5593_07185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5593_07200	COG0824	Thioesterase
I5593_07215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5593_07235	COG0069	glutamate synthase activity
I5593_07300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5593_07395	COG1484	DNA-dependent DNA replication
I5593_07590	COG2026	Addiction module toxin, RelE StbE family
I5593_07630	COG0592	DNA-directed DNA polymerase activity
I5593_07735	COG2814	Major facilitator Superfamily
I5593_07750	COG0511	ligase activity, forming carbon-carbon bonds
I5593_07770	COG1116	anion transmembrane transporter activity
I5593_07770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5593_07775	COG0745	RESPONSE REGULATOR receiver
I5593_07785	COG2146	nitrite reductase [NAD(P)H] activity
I5593_07785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5593_07790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5593_07795	COG0243	molybdopterin cofactor binding
I5593_07810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I5593_07825	COG0315	cyclic pyranopterin monophosphate synthase activity
I5593_07825	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5593_07830	COG0303	'Molybdopterin
I5593_07840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5593_07845	COG0697	spore germination
I5593_07865	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I5593_07870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5593_07925	COG2204	response regulator
I5593_07930	COG3852	Histidine kinase
I5593_07955	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I5593_07960	COG0575	Belongs to the CDS family
I5593_07995	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5593_08010	COG2137	regulation of response to DNA damage stimulus
I5593_08020	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5593_08025	COG1011	Hydrolase
I5593_08050	COG1522	sequence-specific DNA binding
I5593_08060	COG1113	amino acid transport
I5593_08075	COG0659	secondary active sulfate transmembrane transporter activity
I5593_08080	COG2135	peptidase activity
I5593_08095	COG3300	MHYT domain
I5593_08095	COG5001	Diguanylate cyclase
I5593_08115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5593_08115	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I5593_08115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5593_08120	COG1105	Belongs to the carbohydrate kinase PfkB family
I5593_08125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5593_08125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5593_08155	COG0024	Methionine aminopeptidase
I5593_08160	COG0583	DNA-binding transcription factor activity
I5593_08170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I5593_08175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5593_08180	COG0516	GMP reductase activity
I5593_08180	COG0517	IMP dehydrogenase activity
I5593_08205	COG0552	protein localization to endoplasmic reticulum
I5593_08215	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
I5593_08225	COG4890	Cyd operon protein YbgT
I5593_08230	COG1294	oxidase, subunit
I5593_08245	COG1585	Membrane protein implicated in regulation of membrane protease activity
I5593_08255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5593_08260	COG4774	siderophore transport
I5593_08275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5593_08280	COG0569	domain protein
I5593_08285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5593_08315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I5593_08320	COG0542	response to heat
I5593_08345	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5593_08345	COG1902	pentaerythritol trinitrate reductase activity
I5593_08390	COG2323	membrane
I5593_08395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I5593_08405	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5593_08410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5593_08415	COG0183	Belongs to the thiolase family
I5593_08420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5593_08425	COG0596	Alpha beta hydrolase
I5593_08430	COG2271	Major facilitator Superfamily
I5593_08435	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5593_08440	COG3485	protocatechuate 3,4-dioxygenase
I5593_08445	COG3485	protocatechuate 3,4-dioxygenase
I5593_08450	COG0710	3-dehydroquinate dehydratase activity
I5593_08455	COG3420	alginic acid biosynthetic process
I5593_08460	COG3659	wide pore channel activity
I5593_08465	COG4993	Dehydrogenase
I5593_08475	COG2391	methyltransferase activity
I5593_08490	COG1414	Transcriptional regulator
I5593_08495	COG0583	DNA-binding transcription factor activity
I5593_08500	COG1960	acyl-CoA dehydrogenase activity
I5593_08525	COG2814	Major facilitator Superfamily
I5593_08535	COG0154	amidase activity
I5593_08555	COG4638	Rieske (2fe-2S)
I5593_08565	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_08575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5593_08585	COG3733	amine oxidase
I5593_08595	COG1012	belongs to the aldehyde dehydrogenase family
I5593_08605	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5593_08610	COG0183	Belongs to the thiolase family
I5593_08615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5593_08620	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5593_08630	COG4829	muconolactone delta-isomerase
I5593_08635	COG4948	Mandelate Racemase Muconate Lactonizing
I5593_08640	COG0583	DNA-binding transcription factor activity
I5593_08650	COG2186	Transcriptional regulator
I5593_08670	COG1012	belongs to the aldehyde dehydrogenase family
I5593_08685	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5593_08685	COG1902	pentaerythritol trinitrate reductase activity
I5593_08700	COG0789	Transcriptional regulator
I5593_08725	COG1309	transcriptional regulator
I5593_08730	COG0583	DNA-binding transcription factor activity
I5593_08735	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_08740	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_08745	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_08755	COG1960	acyl-CoA dehydrogenase activity
I5593_08765	COG0318	PFAM AMP-dependent synthetase and ligase
I5593_08785	COG2831	hemolysin activation secretion protein
I5593_08790	COG3210	domain, Protein
I5593_08825	COG2188	Transcriptional regulator
I5593_08840	COG0583	DNA-binding transcription factor activity
I5593_08855	COG1566	PFAM secretion protein HlyD family protein
I5593_08870	COG1012	belongs to the aldehyde dehydrogenase family
I5593_08875	COG0129	dihydroxy-acid dehydratase activity
I5593_08885	COG0583	DNA-binding transcription factor activity
I5593_08890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5593_08900	COG2084	Dehydrogenase
I5593_08905	COG2207	Transcriptional regulator
I5593_08920	COG1064	alcohol dehydrogenase
I5593_08930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5593_08935	COG1120	ATPase activity
I5593_08955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I5593_09000	COG1401	restriction endodeoxyribonuclease activity
I5593_09070	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
I5593_09120	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
I5593_09135	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_09150	COG2207	Transcriptional regulator
I5593_09160	COG2205	protein histidine kinase activity
I5593_09165	COG0745	RESPONSE REGULATOR receiver
I5593_09170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5593_09175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5593_09210	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I5593_09220	COG0753	catalase activity
I5593_09235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5593_09295	COG3433	isochorismatase activity
I5593_09295	COG1535	isochorismatase
I5593_09300	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_09305	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I5593_09310	COG4149	molybdate abc transporter
I5593_09315	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5593_09325	COG4638	Rieske (2fe-2S)
I5593_09330	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I5593_09335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5593_09335	COG0543	2 iron, 2 sulfur cluster binding
I5593_09350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5593_09360	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_09375	COG2207	Transcriptional regulator
I5593_09380	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_09385	COG2610	gluconate transmembrane transporter activity
I5593_09395	COG1309	transcriptional regulator
I5593_09415	COG0583	DNA-binding transcription factor activity
I5593_09430	COG2031	fatty acid transporter
I5593_09435	COG0183	Belongs to the thiolase family
I5593_09440	COG0583	DNA-binding transcription factor activity
I5593_09445	COG0583	DNA-binding transcription factor activity
I5593_09460	COG1027	Aspartate ammonia-lyase
I5593_09470	COG0477	Major facilitator Superfamily
I5593_09490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5593_09495	COG4521	taurine ABC transporter
I5593_09510	COG2188	Transcriptional regulator
I5593_09520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I5593_09525	COG1733	regulation of RNA biosynthetic process
I5593_09530	COG3708	Transcriptional regulator
I5593_09530	COG2207	Transcriptional regulator
I5593_09545	COG0730	response to heat
I5593_09555	COG3453	Protein conserved in bacteria
I5593_09555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5593_09565	COG3781	membrane
I5593_09570	COG1063	alcohol dehydrogenase
I5593_09580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5593_09585	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5593_09590	COG0022	dehydrogenase e1 component
I5593_09595	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5593_09600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I5593_09615	COG3706	GGDEF domain
I5593_09630	COG0133	tryptophan synthase activity
I5593_09640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5593_09675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I5593_09700	COG2226	methyltransferase
I5593_09755	COG0842	Transport permease protein
I5593_09760	COG0842	Transport permease protein
I5593_09765	COG1131	(ABC) transporter
I5593_09780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I5593_09785	COG4773	Receptor
I5593_09805	COG0730	response to heat
I5593_09810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I5593_09825	COG0406	alpha-ribazole phosphatase activity
I5593_09845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5593_09875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5593_09885	COG4264	IucA IucC family
I5593_09890	COG4264	IucA IucC family
I5593_09910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5593_09925	COG1960	acyl-CoA dehydrogenase activity
I5593_09930	COG1960	acyl-CoA dehydrogenase activity
I5593_09935	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5593_09940	COG2207	Transcriptional regulator
I5593_09945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5593_09950	COG0776	regulation of translation
I5593_09975	COG0822	iron-sulfur transferase activity
I5593_09980	COG0316	Belongs to the HesB IscA family
I5593_10010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5593_10030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I5593_10035	COG0702	epimerase
I5593_10070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5593_10080	COG0339	signal peptide processing
I5593_10100	COG4206	TonB-dependent receptor
I5593_10130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5593_10135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I5593_10165	COG0776	regulation of translation
I5593_10230	COG0084	hydrolase, TatD family'
I5593_10250	COG1663	tetraacyldisaccharide 4'-kinase activity
I5593_10255	COG1132	(ABC) transporter
I5593_10265	COG0811	peptide transport
I5593_10270	COG1475	DNA binding
I5593_10275	COG1192	Involved in chromosome partitioning
I5593_10285	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I5593_10300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5593_10305	COG0191	fructose-bisphosphate aldolase activity
I5593_10325	COG0424	maF-like protein
I5593_10330	COG2850	peptidyl-arginine hydroxylation
I5593_10340	COG0640	Transcriptional regulator
I5593_10350	COG3619	membrane
I5593_10355	COG3122	Protein conserved in bacteria
I5593_10360	COG1132	(ABC) transporter
I5593_10380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I5593_10385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5593_10395	COG0506	proline dehydrogenase activity
I5593_10395	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5593_10395	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I5593_10400	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5593_10415	COG3698	Phosphodiester glycosidase
I5593_10425	COG2353	YceI-like domain
I5593_10435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I5593_10480	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I5593_10480	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I5593_10505	COG3539	Fimbrial protein
I5593_10510	COG3121	Chaperone
I5593_10535	COG0697	spore germination
I5593_10545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5593_10555	COG0583	DNA-binding transcription factor activity
I5593_10575	COG1309	transcriptional regulator
I5593_10590	COG1522	sequence-specific DNA binding
I5593_10600	COG1126	abc transporter atp-binding protein
I5593_10605	COG0765	amino acid transport
I5593_10610	COG0765	amino acid transport
I5593_10640	COG1464	Belongs to the NlpA lipoprotein family
I5593_10650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5593_10655	COG2011	ABC-type metal ion transport system permease component
I5593_10660	COG0012	GTP binding
I5593_10685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I5593_10725	COG0386	Belongs to the glutathione peroxidase family
I5593_10735	COG0436	Aminotransferase
I5593_10775	COG3634	alkyl hydroperoxide reductase activity
I5593_10790	COG0583	DNA-binding transcription factor activity
I5593_10800	COG0640	Transcriptional regulator
I5593_10815	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I5593_10825	COG0583	DNA-binding transcription factor activity
I5593_10835	COG1953	Uracil, thiamine, allantoin
I5593_10845	COG2175	clavaminate synthase activity
I5593_10850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5593_10855	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
I5593_10860	COG4521	taurine ABC transporter
I5593_10870	COG0477	Major facilitator Superfamily
I5593_10890	COG1271	oxidase subunit
I5593_10895	COG1294	oxidase, subunit
I5593_10905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5593_10945	COG3052	prosthetic group binding
I5593_10950	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I5593_10960	COG0583	DNA-binding transcription factor activity
I5593_10970	COG2814	Major facilitator Superfamily
I5593_10990	COG1346	cytolysis
I5593_11000	COG0583	DNA-binding transcription factor activity
I5593_11005	COG0625	glutathione transferase activity
I5593_11010	COG0625	glutathione transferase activity
I5593_11015	COG0583	DNA-binding transcription factor activity
I5593_11030	COG1045	serine acetyltransferase
I5593_11035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5593_11040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5593_11045	COG1280	lysine exporter protein (LysE YggA)
I5593_11060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5593_11065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5593_11070	COG1126	abc transporter atp-binding protein
I5593_11075	COG0765	amino acid transport
I5593_11080	COG0765	amino acid transport
I5593_11100	COG0784	Response regulator, receiver
I5593_11100	COG2205	protein histidine kinase activity
I5593_11120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5593_11140	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_11190	COG0583	DNA-binding transcription factor activity
I5593_11210	COG0318	PFAM AMP-dependent synthetase and ligase
I5593_11215	COG1309	transcriptional regulator
I5593_11220	COG1960	acyl-CoA dehydrogenase activity
I5593_11225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5593_11230	COG1024	Enoyl-CoA hydratase
I5593_11235	COG4770	biotin carboxylase activity
I5593_11245	COG0583	DNA-binding transcription factor activity
I5593_11260	COG1960	acyl-CoA dehydrogenase activity
I5593_11270	COG2814	Major facilitator Superfamily
I5593_11280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5593_11285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5593_11290	COG2814	Major facilitator Superfamily
I5593_11295	COG1960	acyl-CoA dehydrogenase activity
I5593_11300	COG1024	Enoyl-CoA hydratase
I5593_11305	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_11310	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5593_11315	COG0183	Belongs to the thiolase family
I5593_11325	COG2814	Major facilitator Superfamily
I5593_11335	COG1024	Enoyl-CoA hydratase
I5593_11350	COG1960	acyl-CoA dehydrogenase activity
I5593_11355	COG2814	Major facilitator Superfamily
I5593_11360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5593_11365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5593_11380	COG3842	ATPase activity
I5593_11385	COG1840	ABC-type Fe3 transport system, periplasmic component
I5593_11395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5593_11400	COG1414	Transcriptional regulator
I5593_11410	COG0583	DNA-binding transcription factor activity
I5593_11415	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5593_11420	COG1012	belongs to the aldehyde dehydrogenase family
I5593_11430	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5593_11440	COG1012	belongs to the aldehyde dehydrogenase family
I5593_11445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5593_11450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5593_11455	COG2267	carboxylic ester hydrolase activity
I5593_11475	COG3038	cytochrome b561
I5593_11480	COG0753	catalase activity
I5593_11485	COG2271	Major facilitator Superfamily
I5593_11490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5593_11495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5593_11510	COG2207	Transcriptional regulator
I5593_11550	COG2050	protein possibly involved in aromatic compounds catabolism
I5593_11560	COG3327	negative regulation of DNA-templated transcription, initiation
I5593_11565	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I5593_11570	COG0183	Belongs to the thiolase family
I5593_11575	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5593_11580	COG1024	Enoyl-CoA hydratase
I5593_11585	COG1024	Enoyl-CoA hydratase
I5593_11590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5593_11595	COG2151	metal-sulfur cluster biosynthetic enzyme
I5593_11600	COG3396	Phenylacetate-CoA oxygenase
I5593_11605	COG3460	Phenylacetate-CoA oxygenase
I5593_11610	COG3396	Phenylacetate-CoA oxygenase
I5593_11615	COG2030	dehydratase
I5593_11615	COG1012	belongs to the aldehyde dehydrogenase family
I5593_11620	COG1760	l-serine dehydratase
I5593_11625	COG0531	amino acid
I5593_11630	COG1012	belongs to the aldehyde dehydrogenase family
I5593_11675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5593_11685	COG0789	Transcriptional regulator
I5593_11695	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5593_11710	COG2807	transmembrane transport
I5593_11715	COG0590	tRNA wobble adenosine to inosine editing
I5593_11830	COG1116	anion transmembrane transporter activity
I5593_11835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5593_11845	COG0864	Transcriptional regulator
I5593_11860	COG1733	regulation of RNA biosynthetic process
I5593_11865	COG2249	NAD(P)H dehydrogenase (quinone) activity
I5593_11870	COG0439	Biotin carboxylase
I5593_11885	COG1063	alcohol dehydrogenase
I5593_11895	COG1309	transcriptional regulator
I5593_11910	COG3210	domain, Protein
I5593_11915	COG2831	hemolysin activation secretion protein
I5593_11920	COG0038	chloride channel
I5593_11925	COG4770	biotin carboxylase activity
I5593_11945	COG1914	H( )-stimulated, divalent metal cation uptake system
I5593_11950	COG0583	DNA-binding transcription factor activity
I5593_11985	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5593_12005	COG2814	Major facilitator Superfamily
I5593_12015	COG1560	Kdo2-lipid A biosynthetic process
I5593_12030	COG1522	sequence-specific DNA binding
I5593_12045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I5593_12055	COG4122	O-methyltransferase activity
I5593_12085	COG1538	Outer membrane efflux protein
I5593_12090	COG1137	ATPase activity
I5593_12095	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I5593_12105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5593_12110	COG0517	IMP dehydrogenase activity
I5593_12110	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I5593_12205	COG1278	Cold shock
I5593_12210	COG1280	lysine exporter protein (LysE YggA)
I5593_12240	COG1570	exodeoxyribonuclease VII activity
I5593_12290	COG0583	DNA-binding transcription factor activity
I5593_12295	COG4638	Rieske (2fe-2S)
I5593_12300	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I5593_12305	COG0633	Ferredoxin
I5593_12305	COG0543	2 iron, 2 sulfur cluster binding
I5593_12310	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_12315	COG3135	benzoate transporter
I5593_12320	COG2814	Major facilitator Superfamily
I5593_12335	COG1643	Atp-dependent helicase
I5593_12340	COG0450	alkyl hydroperoxide reductase
I5593_12350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I5593_12360	COG3634	alkyl hydroperoxide reductase activity
I5593_12380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5593_12400	COG0625	glutathione transferase activity
I5593_12410	COG2885	chlorophyll binding
I5593_12445	COG0542	response to heat
I5593_12460	COG1765	OsmC-like protein
I5593_12475	COG0667	Aldo Keto reductase
I5593_12490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I5593_12500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5593_12510	COG0527	aspartate kinase activity
I5593_12520	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I5593_12530	COG3038	cytochrome b561
I5593_12535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I5593_12540	COG2252	PERMEase
I5593_12550	COG2072	flavoprotein involved in K transport
I5593_12565	COG1741	Belongs to the pirin family
I5593_12570	COG1309	transcriptional regulator
I5593_12580	COG0300	oxidoreductase activity
I5593_12585	COG2072	flavoprotein involved in K transport
I5593_12590	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I5593_12635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5593_12650	COG2814	Major facilitator Superfamily
I5593_12655	COG1024	Enoyl-CoA hydratase
I5593_12660	COG1012	belongs to the aldehyde dehydrogenase family
I5593_12670	COG1960	acyl-CoA dehydrogenase activity
I5593_12695	COG2186	Transcriptional regulator
I5593_12700	COG1012	belongs to the aldehyde dehydrogenase family
I5593_12710	COG4948	Mandelate Racemase Muconate Lactonizing
I5593_13060	COG3617	BRO family, N-terminal domain
I5593_13065	COG0582	viral genome integration into host DNA
I5593_13075	COG2721	sulfolactate sulfo-lyase activity
I5593_13080	COG0697	spore germination
I5593_13120	COG1113	amino acid transport
I5593_13140	COG1012	belongs to the aldehyde dehydrogenase family
I5593_13160	COG0531	amino acid
I5593_13170	COG1113	amino acid transport
I5593_13210	COG4269	membrane
I5593_13225	COG1902	pentaerythritol trinitrate reductase activity
I5593_13225	COG0446	pyridine nucleotide-disulphide oxidoreductase
I5593_13235	COG5001	Diguanylate cyclase
I5593_13235	COG2203	Gaf domain
I5593_13235	COG3706	GGDEF domain
I5593_13235	COG4251	negative regulation of phosphorylation
I5593_13245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5593_13265	COG4172	Belongs to the ABC transporter superfamily
I5593_13270	COG4239	(ABC) transporter, permease
I5593_13275	COG4174	ABC transporter (Permease)
I5593_13285	COG0741	lytic transglycosylase activity
I5593_13285	COG1388	LysM domain
I5593_13285	COG1388	LysM domain
I5593_13285	COG0741	lytic transglycosylase activity
I5593_13290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5593_13330	COG0583	DNA-binding transcription factor activity
I5593_13335	COG1279	arginine transmembrane transporter activity
I5593_13355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5593_13360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5593_13365	COG0006	proline dipeptidase activity
I5593_13405	COG2194	sulfuric ester hydrolase activity
I5593_13450	COG0739	heme binding
I5593_13775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5593_13800	COG3384	dioxygenase
I5593_13810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5593_13815	COG2878	Part of a membrane complex involved in electron transport
I5593_13820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5593_13845	COG0768	penicillin binding
I5593_13850	COG0742	ribosomal rna small subunit methyltransferase
I5593_13865	COG0830	nickel cation binding
I5593_13875	COG0804	urea catabolic process
I5593_13915	COG1253	flavin adenine dinucleotide binding
I5593_13920	COG2851	Citrate transporter
I5593_13970	COG1773	rubredoxin
I5593_13975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I5593_13985	COG0583	DNA-binding transcription factor activity
I5593_14015	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I5593_14020	COG4181	ATPase activity
I5593_14065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I5593_14085	COG0306	phosphate transporter
I5593_14095	COG3958	Transketolase
I5593_14100	COG3959	Transketolase, thiamine diphosphate binding domain
I5593_14105	COG2271	Major facilitator Superfamily
I5593_14110	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_14115	COG0583	DNA-binding transcription factor activity
I5593_14130	COG2223	nitrite transmembrane transporter activity
I5593_14135	COG2207	Transcriptional regulator
I5593_14140	COG2066	Belongs to the glutaminase family
I5593_14145	COG0242	peptide deformylase activity
I5593_14150	COG0477	Major facilitator Superfamily
I5593_14160	COG0028	Belongs to the TPP enzyme family
I5593_14175	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_14180	COG2267	carboxylic ester hydrolase activity
I5593_14190	COG2271	Major facilitator Superfamily
I5593_14205	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_14225	COG1414	Transcriptional regulator
I5593_14240	COG1024	Enoyl-CoA hydratase
I5593_14250	COG1215	transferase activity, transferring glycosyl groups
I5593_14255	COG1649	PFAM Uncharacterised BCR, COG1649
I5593_14255	COG0726	polysaccharide deacetylase
I5593_14265	COG4681	YaeQ
I5593_14275	COG0523	cobalamin synthesis protein
I5593_14285	COG1607	acyl-coa hydrolase
I5593_14295	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5593_14300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5593_14305	COG1309	transcriptional regulator
I5593_14330	COG2040	homocysteine
I5593_14335	COG0531	amino acid
I5593_14380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5593_14385	COG0477	Major facilitator Superfamily
I5593_14560	COG0582	viral genome integration into host DNA
I5593_14570	COG0405	Gamma-glutamyltransferase
I5593_14575	COG2814	Major facilitator Superfamily
I5593_14585	COG2050	protein possibly involved in aromatic compounds catabolism
I5593_14600	COG1090	epimerase
I5593_14620	COG0420	3'-5' exonuclease activity
I5593_14645	COG0735	belongs to the Fur family
I5593_14650	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I5593_14670	COG0121	glutamine amidotransferase
I5593_14685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5593_14695	COG0210	DNA helicase
I5593_14700	COG2885	chlorophyll binding
I5593_14705	COG0204	Acyl-transferase
I5593_14720	COG2894	cell division
I5593_14735	COG1280	lysine exporter protein (LysE YggA)
I5593_14740	COG1674	ftsk spoiiie
I5593_14740	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I5593_14745	COG0492	ferredoxin-NADP+ reductase activity
I5593_14750	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
I5593_14760	COG0456	acetyltransferase
I5593_14805	COG1981	membrane
I5593_14820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I5593_14820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5593_14840	COG1012	belongs to the aldehyde dehydrogenase family
I5593_14850	COG0657	acetylesterase activity
I5593_14860	COG0473	3-isopropylmalate dehydrogenase activity
I5593_14865	COG0583	DNA-binding transcription factor activity
I5593_14885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5593_14910	COG0564	pseudouridine synthase activity
I5593_14920	COG0358	DNA primase activity
I5593_14935	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I5593_14965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I5593_14995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5593_15005	COG0351	phosphomethylpyrimidine kinase
I5593_15005	COG0352	thiamine-phosphate diphosphorylase activity
I5593_15005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5593_15010	COG1652	LysM domain
I5593_15035	COG1399	metal-binding, possibly nucleic acid-binding protein
I5593_15040	COG3101	peptidyl-lysine hydroxylation
I5593_15045	COG0009	L-threonylcarbamoyladenylate synthase
I5593_15050	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I5593_15055	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I5593_15070	COG4106	trans-aconitate 2-methyltransferase activity
I5593_15085	COG2226	methyltransferase
I5593_15085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5593_15085	COG0596	Alpha beta hydrolase
I5593_15090	COG1877	trehalose-phosphatase activity
I5593_15095	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I5593_15100	COG2223	nitrite transmembrane transporter activity
I5593_15120	COG1196	nuclear chromosome segregation
I5593_15130	COG0730	response to heat
I5593_15145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5593_15155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5593_15200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5593_15205	COG0489	protein tyrosine kinase activity
I5593_15215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5593_15215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5593_15245	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I5593_15250	COG2081	HI0933 family
I5593_15260	COG0668	transmembrane transport
I5593_15280	COG0583	DNA-binding transcription factor activity
I5593_15300	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I5593_15305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5593_15335	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I5593_15375	COG0745	RESPONSE REGULATOR receiver
I5593_15395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5593_15450	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5593_15465	COG0583	DNA-binding transcription factor activity
I5593_15475	COG0583	DNA-binding transcription factor activity
I5593_15490	COG0583	DNA-binding transcription factor activity
I5593_15495	COG1053	succinate dehydrogenase
I5593_15510	COG1309	transcriptional regulator
I5593_15515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5593_15520	COG2814	Major facilitator Superfamily
I5593_15525	COG1960	acyl-CoA dehydrogenase activity
I5593_15530	COG0583	DNA-binding transcription factor activity
I5593_15535	COG1063	alcohol dehydrogenase
I5593_15565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I5593_15570	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I5593_15575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5593_15595	COG2132	Multicopper oxidase
I5593_15605	COG0561	phosphatase activity
I5593_15610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5593_15620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I5593_15635	COG1214	PFAM Peptidase M22, glycoprotease
I5593_15685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5593_15695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I5593_15700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I5593_15705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5593_15765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5593_15775	COG1846	Transcriptional regulator
I5593_15780	COG1764	response to oxidative stress
I5593_15805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5593_15805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5593_15820	COG0037	tRNA processing
I5593_15830	COG0248	Ppx GppA phosphatase
I5593_15860	COG0072	phenylalanine-tRNA ligase activity
I5593_15900	COG1238	metal cluster binding
I5593_15905	COG0625	glutathione transferase activity
I5593_15920	COG0318	PFAM AMP-dependent synthetase and ligase
I5593_15925	COG3028	Belongs to the UPF0307 family
I5593_15930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5593_15950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5593_15955	COG0617	tRNA 3'-terminal CCA addition
I5593_15960	COG1555	photosystem II stabilization
I5593_15965	COG3956	TIGRFAM MazG family protein
I5593_15975	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5593_15995	COG0784	Response regulator, receiver
I5593_15995	COG2205	protein histidine kinase activity
I5593_15995	COG5002	protein histidine kinase activity
I5593_16000	COG1024	Enoyl-CoA hydratase
I5593_16005	COG2084	Dehydrogenase
I5593_16010	COG3622	Belongs to the hyi family
I5593_16040	COG0697	spore germination
I5593_16050	COG2814	Major facilitator Superfamily
I5593_16075	COG2072	flavoprotein involved in K transport
I5593_16080	COG0492	ferredoxin-NADP+ reductase activity
I5593_16085	COG0431	NADPH-dependent FMN reductase
I5593_16090	COG0798	PFAM Bile acid sodium symporter
I5593_16100	COG0640	Transcriptional regulator
I5593_16135	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5593_16160	COG2132	Multicopper oxidase
I5593_16175	COG2205	protein histidine kinase activity
I5593_16260	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5593_16270	COG0583	DNA-binding transcription factor activity
I5593_16280	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5593_16295	COG0084	hydrolase, TatD family'
I5593_16310	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I5593_16340	COG0440	acetolactate synthase activity
I5593_16345	COG0028	Belongs to the TPP enzyme family
I5593_16370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5593_16375	COG1136	(ABC) transporter
I5593_16375	COG0577	efflux transmembrane transporter activity
I5593_16380	COG1538	Outer membrane efflux protein
I5593_16395	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I5593_16400	COG1162	GTPase activity
I5593_16410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5593_16450	COG1426	Protein conserved in bacteria
I5593_16485	COG0793	Belongs to the peptidase S41A family
I5593_16500	COG2267	carboxylic ester hydrolase activity
I5593_16510	COG1012	belongs to the aldehyde dehydrogenase family
I5593_16515	COG3265	gluconokinase activity
I5593_16525	COG0800	Aldolase
I5593_16535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I5593_16540	COG0280	phosphate acetyltransferase
I5593_16540	COG0857	belongs to the CobB CobQ family
I5593_16545	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I5593_16545	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I5593_16565	COG0740	serine-type endopeptidase activity
I5593_16575	COG4774	siderophore transport
I5593_16585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5593_16595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5593_16595	COG2813	Specifically methylates the guanine in position
I5593_16745	COG0788	formyltetrahydrofolate deformylase activity
I5593_16770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5593_16770	COG4651	solute:proton antiporter activity
I5593_16790	COG0724	RNA recognition motif
I5593_16795	COG0210	DNA helicase
I5593_16820	COG1733	regulation of RNA biosynthetic process
I5593_16830	COG2900	Belongs to the SlyX family
I5593_16835	COG0488	(ABC) transporter
I5593_16840	COG1280	lysine exporter protein (LysE YggA)
I5593_16845	COG1560	Kdo2-lipid A biosynthetic process
I5593_16855	COG1301	dicarboxylic acid transport
I5593_16910	COG0473	3-isopropylmalate dehydrogenase activity
I5593_16975	COG0583	DNA-binding transcription factor activity
I5593_16985	COG0625	glutathione transferase activity
I5593_16990	COG2378	regulation of single-species biofilm formation
I5593_16995	COG0546	phosphoglycolate phosphatase activity
I5593_17005	COG1530	ribonuclease E activity
I5593_17010	COG0318	PFAM AMP-dependent synthetase and ligase
I5593_17025	COG0583	DNA-binding transcription factor activity
I5593_17030	COG4221	oxidoreductase activity
I5593_17035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5593_17045	COG0534	Mate efflux family protein
I5593_17060	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I5593_17085	COG0493	'glutamate synthase
I5593_17085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I5593_17095	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I5593_17100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5593_17115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5593_17125	COG0644	oxidoreductase
I5593_17125	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I5593_17130	COG0425	Belongs to the sulfur carrier protein TusA family
I5593_17135	COG4535	Mg2 and Co2 transporter CorC
I5593_17145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5593_17165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5593_17170	COG0475	glutathione-regulated potassium exporter activity
I5593_17170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5593_17185	COG0484	heat shock protein binding
I5593_17190	COG0789	Transcriptional regulator
I5593_17195	COG0598	Magnesium transport protein CorA
I5593_17210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5593_17215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5593_17220	COG1074	ATP-dependent DNA helicase activity
I5593_17225	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I5593_17245	COG2226	methyltransferase
I5593_17260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I5593_17265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I5593_17280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5593_17280	COG2111	Na H antiporter
I5593_17285	COG1006	Multisubunit Na H antiporter MnhC subunit
I5593_17290	COG0651	ATP synthesis coupled electron transport
I5593_17295	COG1863	multisubunit Na H antiporter MnhE subunit
I5593_17300	COG2212	antiporter activity
I5593_17305	COG1320	monovalent cation:proton antiporter activity
I5593_17320	COG0195	Participates in both transcription termination and antitermination
I5593_17370	COG0237	dephospho-CoA kinase activity
I5593_17380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5593_17395	COG0497	DNA recombination
I5593_17405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I5593_17435	COG2169	Transcriptional regulator
I5593_17435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5593_17440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5593_17500	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I5593_17515	COG0326	Molecular chaperone. Has ATPase activity
I5593_17530	COG2056	Na+-H+ antiporter family
I5593_17630	COG0546	phosphoglycolate phosphatase activity
I5593_17635	COG1716	ATPase activity
I5593_17680	COG0181	hydroxymethylbilane synthase activity
I5593_17690	COG3275	phosphorelay sensor kinase activity
I5593_17710	COG1538	Outer membrane efflux protein
I5593_17715	COG0697	spore germination
I5593_17740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I5593_17745	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5593_17750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5593_17755	COG0772	Belongs to the SEDS family
I5593_17780	COG4974	Belongs to the 'phage' integrase family
I5593_17785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5593_17795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5593_17805	COG2197	response regulator
I5593_17820	COG0793	Belongs to the peptidase S41A family
I5593_17825	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I5593_17830	COG0795	lipopolysaccharide-transporting ATPase activity
I5593_17870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5593_17870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5593_17880	COG0004	ammonium transporteR
I5593_17885	COG0347	Belongs to the P(II) protein family
I5593_17895	COG0606	chelatase, subunit chli
I5593_17925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5593_17950	COG0789	Transcriptional regulator
I5593_17960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I5593_17965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5593_17970	COG1538	Outer membrane efflux protein
I5593_17980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5593_18015	COG0798	PFAM Bile acid sodium symporter
I5593_18050	COG4691	Plasmid stability protein
I5593_18075	COG0431	NADPH-dependent FMN reductase
I5593_18080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5593_18130	COG0606	chelatase, subunit chli
I5593_18135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5593_18145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5593_18160	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I5593_18175	COG0318	PFAM AMP-dependent synthetase and ligase
I5593_18185	COG0477	Major facilitator Superfamily
I5593_18190	COG2860	membrane
I5593_18200	COG1253	flavin adenine dinucleotide binding
I5593_18210	COG2814	Major facilitator Superfamily
I5593_18220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5593_18255	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5593_18265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5593_18300	COG1309	transcriptional regulator
I5593_18335	COG0758	DNA mediated transformation
I5593_18345	COG0697	spore germination
I5593_18350	COG1309	transcriptional regulator
I5593_18365	COG0386	Belongs to the glutathione peroxidase family
I5593_18430	COG1121	(ABC) transporter
I5593_18435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5593_18440	COG1280	lysine exporter protein (LysE YggA)
I5593_18445	COG2837	iron assimilation
I5593_18450	COG0281	malic enzyme
I5593_18495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5593_18495	COG0519	Catalyzes the synthesis of GMP from XMP
I5593_18500	COG4399	Belongs to the UPF0754 family
I5593_18505	COG2259	Doxx family
I5593_18510	COG0586	Pfam SNARE associated Golgi protein
I5593_18525	COG1192	Involved in chromosome partitioning
I5593_18535	COG0271	Belongs to the BolA IbaG family
I5593_18555	COG2267	carboxylic ester hydrolase activity
I5593_18575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I5593_18575	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I5593_18575	COG3321	synthase
I5593_18575	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5593_18580	COG1960	acyl-CoA dehydrogenase activity
I5593_18590	COG2197	response regulator
I5593_18600	COG3916	Acyl-homoserine-lactone synthase
I5593_18605	COG0477	Major facilitator Superfamily
I5593_18610	COG1024	Enoyl-CoA hydratase
I5593_18615	COG1024	Enoyl-CoA hydratase
I5593_18620	COG1960	acyl-CoA dehydrogenase activity
I5593_18625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5593_18645	COG1113	amino acid transport
I5593_18650	COG1113	amino acid transport
I5593_18655	COG0251	oxidation-reduction process
I5593_18695	COG0564	pseudouridine synthase activity
I5593_18780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5593_18795	COG1802	Transcriptional regulator
I5593_18800	COG1448	Aminotransferase
I5593_18805	COG0277	FAD linked oxidase domain protein
I5593_18815	COG2186	Transcriptional regulator
I5593_18825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5593_18830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5593_18845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5593_18850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5593_18875	COG0438	transferase activity, transferring glycosyl groups
I5593_18905	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5593_18910	COG1596	polysaccharide export
I5593_18935	COG0728	peptidoglycan biosynthetic process
I5593_18940	COG3023	N-Acetylmuramoyl-L-alanine amidase
I5593_18995	COG0546	phosphoglycolate phosphatase activity
I5593_19000	COG1028	Short-chain dehydrogenase reductase Sdr
I5593_19020	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5593_19025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5593_19030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5593_19035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5593_19040	COG1116	anion transmembrane transporter activity
I5593_19045	COG1309	transcriptional regulator
I5593_19050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5593_19060	COG0196	riboflavin kinase activity
I5593_19065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I5593_19075	COG1047	Peptidyl-prolyl cis-trans
I5593_19115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5593_19120	COG0657	acetylesterase activity
I5593_19170	COG2951	lytic endotransglycosylase activity
I5593_19175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5593_19190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5593_19200	COG0671	phosphoesterase, PA-phosphatase related
I5593_19205	COG0861	Integral membrane protein TerC family
I5593_19215	COG0754	glutathionylspermidine amidase activity
I5593_19225	COG0402	S-adenosylhomocysteine deaminase activity
I5593_19240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5593_19245	COG1230	cation diffusion facilitator family transporter
I5593_19260	COG0706	membrane insertase activity
I5593_19290	COG1846	Transcriptional regulator
I5593_19295	COG1764	response to oxidative stress
I5593_19320	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I5593_19325	COG1764	response to oxidative stress
I5593_19330	COG1846	Transcriptional regulator
I5593_19355	COG1846	Transcriptional regulator
I5593_19360	COG1764	response to oxidative stress