locus-tag class description ACX60_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ACX60_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACX60_00030 ENOG4105DQR SNARE associated Golgi ACX60_00035 ENOG4105C5H ABC transporter ACX60_00040 ENOG4108821 RND type efflux pump ACX60_00045 ENOG4108821 RND type efflux pump ACX60_00050 ENOG4108821 RND type efflux pump ACX60_00060 ENOG4105D74 hydrolase ACX60_00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) ACX60_00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ACX60_00110 ENOG4105C8J )-transporter ACX60_00120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ACX60_00150 ENOG4105C2W permease ACX60_00160 ENOG4108IG5 Transcriptional regulator ACX60_00165 ENOG4105DJY efflux transporter, rnd family, mfp subunit ACX60_00200 ENOG4105F27 Major Facilitator ACX60_00205 ENOG4105CV8 reductase ACX60_00210 ENOG4105HEI LysR family (Transcriptional regulator ACX60_00225 ENOG4105DQ4 alcohol dehydrogenase ACX60_00230 ENOG4108R3E Dna-3-methyladenine glycosylase i ACX60_00245 ENOG4105CEN a g-specific adenine glycosylase ACX60_00265 ENOG4108ZZ3 UPF0260 protein ACX60_00275 ENOG4105D1H recombination factor protein RarA ACX60_00280 ENOG4105S64 Formate nitrite transporter ACX60_00300 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACX60_00305 ENOG4108RWI nicotinamidase ACX60_00310 ENOG4105C09 Bile acid ACX60_00315 ENOG4107QI1 Mate efflux family protein ACX60_00320 ENOG4105EWC Purine nucleoside phosphorylase ACX60_00340 ENOG4108RXX maleylacetoacetate isomerase ACX60_00350 ENOG4105C85 amino acid ACX60_00360 ENOG4105CKI cobalamin synthesis protein ACX60_00370 ENOG4105CZE histidine utilization repressor ACX60_00375 ENOG41090B9 response to stress ACX60_00390 ENOG4105C85 amino acid ACX60_00400 ENOG41088SP formiminoglutamate hydrolase ACX60_00420 ENOG4108NIW Leucine export protein LeuE ACX60_00440 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ACX60_00450 ENOG4108ZAI phosphatidylglycerophosphatase a ACX60_00455 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ACX60_00470 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ACX60_00515 ENOG4105KHC sulfurtransferase ACX60_00530 ENOG4105BZU Histidine kinase ACX60_00535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACX60_00550 ENOG4107QJQ Mate efflux family protein ACX60_00555 ENOG4105CHM Aminotransferase ACX60_00560 ENOG4106BRA Membrane ACX60_00575 ENOG4105D9M gamma-glutamylcysteine synthetase ACX60_00595 ENOG4105MP0 transposase ACX60_00645 ENOG4105IPS esterase ACX60_00650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACX60_00655 ENOG4108Z2U ureidoglycolate hydrolase ACX60_00665 ENOG41061H0 Monooxygenase ACX60_00680 ENOG41084YZ Hydrolase ACX60_00710 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ACX60_00715 ENOG4105BZU Histidine kinase ACX60_00730 ENOG4105KUZ arsenate reductase ACX60_00735 ENOG4105CGK Exodeoxyribonuclease III ACX60_00760 ENOG4105D7Z glutathione synthase ACX60_00780 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) ACX60_00785 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ACX60_00790 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ACX60_00805 ENOG41063SB peptidase ACX60_00810 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ACX60_00815 ENOG4107QSN dihydrolipoamide acetyltransferase ACX60_00830 ENOG4105E0K tonB-dependent siderophore receptor ACX60_00845 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ACX60_00860 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ACX60_00870 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ACX60_00880 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACX60_00885 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ACX60_00895 ENOG4105D64 Mechanosensitive ion channel ACX60_00905 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ACX60_00910 ENOG4108W2Y isochorismatase ACX60_00920 ENOG4105FBW Monooxygenase ACX60_00925 ENOG4108UZX fmn reductase ACX60_00940 ENOG4105BZU Histidine kinase ACX60_00945 ENOG41062QD Membrane ACX60_00950 ENOG4107QN1 sodium solute ACX60_00960 ENOG4105C94 Transporter ACX60_00970 ENOG4105BZU Histidine kinase ACX60_00975 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ACX60_00980 ENOG4108WUH Transcriptional regulator, TetR family ACX60_00985 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ACX60_00995 ENOG4105RA2 Membrane ACX60_01000 ENOG4105DWF phosphomethylpyrimidine kinase ACX60_01010 ENOG4107RDB Major Facilitator ACX60_01015 ENOG4108UUM single-stranded DNA-binding protein ACX60_01025 ENOG4108UMN azlc family ACX60_01035 ENOG4105C85 amino acid ACX60_01045 ENOG4108JPW Aminotransferase ACX60_01050 ENOG4105C26 Dehydrogenase ACX60_01060 ENOG4105CHJ isochorismatase hydrolase ACX60_01065 ENOG4105EUB pirin domain protein ACX60_01095 ENOG4105D94 Major Facilitator Superfamily ACX60_01100 ENOG4106NZI LysR family Transcriptional regulator ACX60_01125 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) ACX60_01145 ENOG4105KVH Transcriptional regulator ACX60_01175 ENOG4105KVH Transcriptional regulator ACX60_01180 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ACX60_01200 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain ACX60_01205 ENOG4108UQN AraC family transcriptional regulator ACX60_01260 ENOG4105CUV Homoserine Kinase ACX60_01275 ENOG41061CK Antibiotic biosynthesis monooxygenase ACX60_01305 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ACX60_01335 ENOG4105CYC Transferase ACX60_01340 ENOG4105E0F Histidine kinase ACX60_01345 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ACX60_01350 ENOG4105BZM domain protein ACX60_01355 ENOG4105CHH sulfate transporter ACX60_01360 ENOG4105PDP Short chain dehydrogenase ACX60_01385 ENOG4105C5H ABC transporter ACX60_01450 ENOG4108IQI permease ACX60_01475 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ACX60_01490 ENOG4105CJN penicillin-binding protein ACX60_01495 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ACX60_01500 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) ACX60_01515 ENOG4105DHI Methyltransferase ACX60_01520 ENOG4108JQC penicillin-binding protein 1A ACX60_01545 ENOG4105E4G Type IV pilus ACX60_01565 ENOG4105CBC glutamate synthase ACX60_01570 ENOG4105BZ8 glutamate synthase ACX60_01580 ENOG4108V0P LemA family ACX60_01585 ENOG4105HA9 of methanol dehydrogenase type ACX60_01600 ENOG4108YSG O-Antigen polymerase ACX60_01605 ENOG4108UQY Iron-storage protein ACX60_01615 ENOG4105KME endoribonuclease L-psp ACX60_01620 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACX60_01630 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ACX60_01680 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ACX60_01695 ENOG4107IFA Lipase (EC 3.1.1.3) ACX60_01700 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) ACX60_01705 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ACX60_01730 ENOG4108JQ1 Dehydrogenase ACX60_01735 ENOG4105CQB FAD linked oxidase domain protein ACX60_01745 ENOG4105VRH Antibiotic biosynthesis monooxygenase ACX60_01750 ENOG4105NF4 modulator of drug activity ACX60_01760 ENOG4107QF7 multi-drug ACX60_01765 ENOG4105EM2 membrane ACX60_01770 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ACX60_01775 ENOG4105IPI Membrane ACX60_01780 ENOG4107SKI cobyrinic Acid a,c-diamide synthase ACX60_01810 ENOG4108IQI permease ACX60_01815 ENOG4105D82 Glutamate dehydrogenase ACX60_01820 ENOG4105C8Y Acetylornithine aminotransferase ACX60_01830 ENOG4105C26 Dehydrogenase ACX60_01855 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ACX60_01920 ENOG4105W87 Cbs domain ACX60_01925 ENOG41067S9 phage shock protein C, PspC ACX60_01935 ENOG4105CSU acyl-Coa dehydrogenase ACX60_01950 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) ACX60_01965 ENOG4105ECY inositol monophosphatase ACX60_01970 ENOG4105C1J atp-dependent rna helicase ACX60_01980 ENOG4105DHJ ABC, transporter ACX60_01985 ENOG4105CY3 ABC transporter, permease ACX60_01995 ENOG4105E3I toluene tolerance ACX60_02005 ENOG4105D7N magnesium and cobalt transport protein CorA ACX60_02010 ENOG4108URH decarboxylase ACX60_02020 ENOG4105MJ2 Competence protein ACX60_02025 ENOG4105CB5 ATP-dependent DNA helicase recG ACX60_02045 ENOG4105C29 acyl-CoA thioesterase ACX60_02050 ENOG4105CK2 sodium dicarboxylate symporter ACX60_02065 ENOG4105KPV Transcriptional regulator ACX60_02075 ENOG4105D7A ATP-binding protein ACX60_02080 ENOG4105C28 cystathionine ACX60_02085 ENOG41089BK Glutamine amido-transferase ACX60_02195 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ACX60_02200 ENOG41067V7 50S ribosomal protein L36 ACX60_02210 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ACX60_02235 ENOG4105C1G acyl-Coa dehydrogenase ACX60_02270 ENOG4105VKU nucleicacid-binding protein ACX60_02275 ENOG4105DGW oligopeptidase A ACX60_02280 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ACX60_02325 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase ACX60_02330 ENOG4108K2B transcriptional regulator ACX60_02340 ENOG4107S2Z UPF0761 membrane protein ACX60_02345 ENOG4105CS1 NAD(P)H quinone oxidoreductase ACX60_02375 ENOG4105C9A Phoh family ACX60_02385 ENOG4105E4C Lytic transglycosylase catalytic ACX60_02415 ENOG4105D6S protein involved in catabolism of external DNA ACX60_02420 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase ACX60_02465 ENOG4105C1G acyl-Coa dehydrogenase ACX60_02470 ENOG4108RZE Tetr family transcriptional regulator ACX60_02485 ENOG4107QX3 carboxylase ACX60_02490 ENOG4105C1G acyl-Coa dehydrogenase ACX60_02510 ENOG4105KB2 stringent starvation protein b ACX60_02515 ENOG4107MKT Stringent starvation protein a ACX60_02520 ENOG4108UJD 30S ribosomal protein S9 ACX60_02530 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) ACX60_02535 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ACX60_02540 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) ACX60_02560 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ACX60_02570 ENOG4107RZC phospholipase d ACX60_02580 ENOG4105UYK outer membrane protein a ACX60_02585 ENOG4108KHX Diguanylate cyclase ACX60_02630 ENOG4107QPB Beta-lactamase domain protein ACX60_02635 ENOG4107U2T alpha beta ACX60_02645 ENOG4105NAU thioesterase Superfamily protein ACX60_02680 ENOG4105XWI UPF0304 protein ACX60_02755 ENOG4105GR3 Histidine kinase ACX60_02770 ENOG4105E3B Multicopper oxidase ACX60_02795 ENOG4108IJF Heavy metal efflux pump, CzcA ACX60_02805 ENOG4105CE1 Ferrous iron transport protein b ACX60_02840 ENOG4105DFP Integrase ACX60_02865 ENOG4105K9H YciI-like protein ACX60_02875 ENOG4105DB7 PHP domain protein ACX60_02880 ENOG4105FFC UPF0187 protein ACX60_02890 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ACX60_02895 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ACX60_02900 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ACX60_02905 ENOG4105VIE preprotein translocase, subunit YajC ACX60_02975 ENOG4105BZU Histidine kinase ACX60_02980 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) ACX60_02985 ENOG4105CM2 brancheD-chain amino acid aminotransferase ACX60_03000 ENOG4107BJW polysaccharide deacetylase ACX60_03010 ENOG4108PQP glycosyl transferase group 1 ACX60_03025 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ACX60_03050 ENOG4105UGU tonB-dependent Receptor ACX60_03070 ENOG4108VY7 phosphate-starvation-inducible protein PsiE ACX60_03075 ENOG4105CSU acyl-Coa dehydrogenase ACX60_03080 ENOG4105CSU acyl-Coa dehydrogenase ACX60_03090 ENOG4105EB3 Histidine kinase ACX60_03095 ENOG4105E3W Two component transcriptional regulator (Winged helix family ACX60_03100 ENOG4105CNG UPF0061 protein ACX60_03120 ENOG4108WBT adenosyltransferase ACX60_03125 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) ACX60_03135 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ACX60_03170 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ACX60_03190 ENOG4105D3R alkyl hydroperoxide reductase ACX60_03205 ENOG4105CSH Transporter ACX60_03210 ENOG4108UT2 hemolysin iii ACX60_03220 ENOG41082BV acetyltransferase ACX60_03240 ENOG4105CHU acetyl-coa acetyltransferase ACX60_03245 ENOG4108R6W Transcriptional regulator, ARAC family ACX60_03255 ENOG4105TW1 Carbohydrate-selective porin OprB ACX60_03260 ENOG4105DZG Dehydrogenase ACX60_03265 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ACX60_03285 ENOG4105CHU acetyl-coa acetyltransferase ACX60_03305 ENOG4105E0Y RtcB Protein ACX60_03310 ENOG4108IQI permease ACX60_03320 ENOG4105C2W permease ACX60_03340 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) ACX60_03350 ENOG4108VX5 3-methyladenine DNA glycosylase ACX60_03355 ENOG4105CHB tonB-dependent Receptor ACX60_03360 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACX60_03365 ENOG4108N2Y auxin Efflux ACX60_03375 ENOG4105T95 Thiol disulfide interChange protein ACX60_03380 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) ACX60_03390 ENOG4105K78 MarR family Transcriptional regulator ACX60_03395 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ACX60_03400 ENOG4105KWI UPF0339 protein ACX60_03425 ENOG4108UNF response regulator ACX60_03430 ENOG4105M3Z response regulator ACX60_03435 ENOG4108ZGA chew protein ACX60_03440 ENOG4105C8Q Methyl-accepting chemotaxis ACX60_03445 ENOG4105CBS Chea signal transduction histidine kinase ACX60_03460 ENOG4106HKS Entericidin EcnA/B family ACX60_03470 ENOG4105WD1 Membrane ACX60_03475 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ACX60_03515 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ACX60_03525 ENOG4105EM2 membrane ACX60_03530 ENOG4105C2C drug resistance transporter, Bcr CflA ACX60_03545 ENOG4105BZG amino acid carrier protein ACX60_03550 ENOG4105D78 K07001 NTE family protein ACX60_03555 ENOG4105C7B Threonine dehydratase ACX60_03565 ENOG4105C9K Endothelin-converting enzyme 1 ACX60_03590 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ACX60_03600 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ACX60_03605 ENOG4105DFF Rod shape-determining protein mreb ACX60_03610 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ACX60_03615 ENOG4105VQ7 Rod shape-determining protein MreD ACX60_03620 ENOG4108Z03 MAF-like protein ACX60_03625 ENOG4105C03 ribonuclease ACX60_03635 ENOG4105D8T Acyltransferase ACX60_03645 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein ACX60_03655 ENOG4108X0B nad(p)h dehydrogenase (quinone) ACX60_03680 ENOG4105CF7 AraC family transcriptional regulator ACX60_03700 ENOG4105C85 amino acid ACX60_03705 ENOG4105C7F AcnD-accessory protein PrpF ACX60_03710 ENOG4105CTB Polyprenyl synthetase ACX60_03715 ENOG4105MSB protein, conserved in bacteria ACX60_03730 ENOG4105D78 K07001 NTE family protein ACX60_03750 ENOG4105DIJ Phosphoethanolamine transferase ACX60_03755 ENOG4105XJC Two component transcriptional regulator (Winged helix family ACX60_03760 ENOG4105DHQ Histidine kinase ACX60_03775 ENOG4108M0I Transcriptional regulator ACX60_03795 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ACX60_03815 ENOG4105K8R UPF0145 protein ACX60_03820 ENOG4105K8R UPF0145 protein ACX60_03825 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ACX60_03830 ENOG4105BZS acriflavin resistance protein ACX60_03835 ENOG4105C1P efflux transporter, rnd family, mfp subunit ACX60_03840 ENOG410841Q phosphoesterase PA-phosphatase related protein ACX60_03870 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) ACX60_03885 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ACX60_03890 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ACX60_03895 ENOG4105KVH Transcriptional regulator ACX60_03905 ENOG4105CUB amino acid ACX60_03920 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) ACX60_03925 ENOG41084BA UPF0250 protein ACX60_03930 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACX60_03965 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit ACX60_03970 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein ACX60_03980 ENOG4105E33 succinate dehydrogenase ACX60_03985 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ACX60_03990 ENOG4105C7S Dehydrogenase ACX60_03995 ENOG4107QN2 dihydrolipoyl dehydrogenase ACX60_04005 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ACX60_04015 ENOG4105CKW Inner membrane protein yedI ACX60_04020 ENOG4105CGZ zinc metallopeptidase ACX60_04025 ENOG4105EEQ Na H antiporter ACX60_04040 ENOG4105PNM synthesis protein ACX60_04055 ENOG41080TK Universal stress protein ACX60_04065 ENOG4108UQ8 endoribonuclease L-psp ACX60_04070 ENOG4108IG5 Transcriptional regulator ACX60_04080 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ACX60_04085 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ACX60_04100 ENOG4105HBR Rna-binding protein ACX60_04110 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACX60_04115 ENOG4105EEI dihydropteroate synthase ACX60_04165 ENOG4105CSH Transporter ACX60_04170 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ACX60_04175 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ACX60_04190 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ACX60_04205 ENOG41080IJ Diacylglycerol kinase ACX60_04215 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ACX60_04220 ENOG4105BZS acriflavin resistance protein ACX60_04235 ENOG4105E4C Lytic transglycosylase catalytic ACX60_04255 ENOG4108RRZ Transcription elongation factor GreB ACX60_04270 ENOG4105CEY Amp-dependent synthetase and ligase ACX60_04280 ENOG4105YCT UPF0386 protein ACX60_04350 ENOG4105BZW Glycerate kinase ACX60_04355 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit ACX60_04360 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ACX60_04375 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) ACX60_04385 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ACX60_04390 ENOG4105C85 amino acid ACX60_04400 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ACX60_04410 ENOG4105N14 lysine exporter protein LysE YggA ACX60_04415 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACX60_04420 ENOG4105BZJ Electron transfer flavoprotein ACX60_04425 ENOG4105C10 Electron transfer flavoprotein ACX60_04430 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACX60_04465 ENOG4107KET secretion protein, HlyD family ACX60_04495 ENOG4105D60 lipoprotein releasing system transmembrane protein ACX60_04500 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ACX60_04505 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 ACX60_04515 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ACX60_04520 ENOG4107R6F Alpha Beta Hydrolase Fold protein ACX60_04525 ENOG4108V3E phosphoribosylglycinamide formyltransferase ACX60_04535 ENOG4105C02 permease ACX60_04585 ENOG4105KCK Peptidoglycan-associated lipoprotein ACX60_04590 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) ACX60_04600 ENOG4105M8F Biopolymer transport protein exbD tolR ACX60_04605 ENOG4105E02 MotA TolQ exbB proton channel ACX60_04610 ENOG4107YD3 Thioesterase ACX60_04615 ENOG4105CH2 amidohydrolase ACX60_04635 ENOG4108ETH Formylglycinamide ribotide synthetase ACX60_04660 ENOG4105E4F Isochorismate synthase ACX60_04670 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ACX60_04675 ENOG4105C0W non-ribosomal peptide synthetase ACX60_04680 ENOG4105C0W non-ribosomal peptide synthetase ACX60_04685 ENOG4105CEY Amp-dependent synthetase and ligase ACX60_04690 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ACX60_04695 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) ACX60_04700 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ACX60_04745 ENOG4107QI1 Mate efflux family protein ACX60_04750 ENOG4108JJA ABC, transporter ACX60_04755 ENOG4105C42 Type I secretion membrane fusion protein (HlyD ACX60_04825 ENOG4105EGD dinuclear metal center protein, YbgI family ACX60_04830 ENOG4108UKI Enoyl-CoA hydratase ACX60_04845 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ACX60_04860 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) ACX60_04865 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ACX60_04880 ENOG4107R11 Transcriptional regulator ACX60_04885 ENOG4108IJ6 ABC transporter ACX60_04895 ENOG4108I5D sulfate abc transporter ACX60_04905 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ACX60_04910 ENOG4105YAZ 4-amino-4-deoxychorismate lyase ACX60_04915 ENOG4105HHA aminodeoxychorismate lyase ACX60_04930 ENOG4108IYU L-aspartate oxidase ACX60_04935 ENOG4105C0H protease ACX60_04945 ENOG41068WN ACX60_04955 ENOG4105C3F Signal peptidase i ACX60_04970 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ACX60_04980 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) ACX60_04985 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) ACX60_04990 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase ACX60_04995 ENOG4105EMU Dehydrogenase ACX60_05020 ENOG4105F7F Chaperone ACX60_05040 ENOG4105BZU Histidine kinase ACX60_05050 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ACX60_05060 ENOG4105DTR rard protein ACX60_05095 ENOG4107QS8 (LipO)protein ACX60_05100 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ACX60_05105 ENOG4105EA8 2-Nitropropane dioxygenase ACX60_05135 ENOG4107R8N Glycosyl transferase, family 2 ACX60_05150 ENOG4105CVP deoxyribo-dipyrimidine photolyase ACX60_05155 ENOG4108YZY peptidylprolyl cis-trans isomerase ACX60_05160 ENOG4105CEP NADH dehydrogenase ACX60_05165 ENOG4105DZ1 carboxypeptidase ACX60_05175 ENOG4105E9K Isocitrate dehydrogenase ACX60_05180 ENOG4108R99 pseudouridine synthase ACX60_05200 ENOG4105CBP Major Facilitator ACX60_05205 ENOG4105EGI Transcriptional regulator ACX60_05210 ENOG4108ETY sodium dicarboxylate symporter ACX60_05215 ENOG4105JAB phenazine biosynthesis protein, phzf family ACX60_05245 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) ACX60_05260 ENOG4105D3G Pseudouridine synthase ACX60_05265 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) ACX60_05280 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ACX60_05290 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ACX60_05305 ENOG4108JPW Aminotransferase ACX60_05310 ENOG4105DY8 decarboxylase ACX60_05320 ENOG4105F7P transcriptional regulator AsnC family ACX60_05325 ENOG4107RA9 decarboxylase ACX60_05330 ENOG4105C85 amino acid ACX60_05335 ENOG4105CVA phosphate ACX60_05340 ENOG4105C8U phosphate abc transporter ACX60_05350 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ACX60_05355 ENOG4105ERU peptidase ACX60_05370 ENOG4107QTF adenylosuccinate lyase ACX60_05390 ENOG4108Z0R Transferase ACX60_05395 ENOG4105DZ1 carboxypeptidase ACX60_05415 ENOG4108K5P (LipO)protein ACX60_05420 ENOG4105EJC lysr family transcriptional regulator ACX60_05425 ENOG4105DAN ATP-dependent protease ACX60_05440 ENOG4105DHU Bile acid ACX60_05450 ENOG41066DG (EAL) domain protein ACX60_05460 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ACX60_05470 ENOG4105D22 carbon starvation protein ACX60_05475 ENOG4105VCD cytoplasmic protein ACX60_05515 ENOG4105CHJ isochorismatase hydrolase ACX60_05520 ENOG4105CR8 Transcriptional regulator ACX60_05530 ENOG4107RN6 Monooxygenase ACX60_05535 ENOG4105D74 hydrolase ACX60_05575 ENOG4105C2I pirin domain protein ACX60_05585 ENOG4105WWK YheO domain protein ACX60_05600 ENOG4105CEY Amp-dependent synthetase and ligase ACX60_05615 ENOG4108IPW abc transporter atp-binding protein ACX60_05635 ENOG4105C0W non-ribosomal peptide synthetase ACX60_05640 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ACX60_05645 ENOG4105WQI isochorismatase ACX60_05660 ENOG4105BZ1 (ABC) transporter ACX60_05695 ENOG4105NX3 Membrane ACX60_05715 ENOG4105EUJ GTP cyclohydrolase i ACX60_05725 ENOG4105C7W Xanthine dehydrogenase ACX60_05755 ENOG4105CD8 aminopeptidase N ACX60_05760 ENOG4105DDQ anthranilate synthase ACX60_05770 ENOG4105DUX Transporter ACX60_05775 ENOG4105C5F glutamine synthetase ACX60_05785 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) ACX60_05820 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ACX60_05825 ENOG4107QNR UPF0135 protein ACX60_05830 ENOG4105C0H protease ACX60_05840 ENOG4105C6K Malic enzyme ACX60_05845 ENOG4105BZU Histidine kinase ACX60_05850 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ACX60_05855 ENOG4105SYT Methylenetetrahydrofolate reductase ACX60_05860 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) ACX60_05875 ENOG4107QPN acyl-Coa dehydrogenase ACX60_05880 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ACX60_05885 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) ACX60_05900 ENOG4107RNU major facilitator superfamily MFS_1 ACX60_05910 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ACX60_05915 ENOG4105CE9 30S ribosomal protein S2 ACX60_05955 ENOG4105CVE Lytic murein transglycosylase ACX60_05960 ENOG4105CNI cell division protein FtsW ACX60_05975 ENOG4105E3A (ABC) transporter ACX60_05980 ENOG4105DA5 (ABC) transporter ACX60_06010 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ACX60_06020 ENOG4105ENT Efflux transporter rnd family, mfp subunit ACX60_06030 ENOG4105E89 ABC transporter ACX60_06035 ENOG4105DSP amino acid AbC transporter ACX60_06040 ENOG4106YG3 ABC transporter ACX60_06045 ENOG4108JEH abc transporter atp-binding protein ACX60_06055 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ACX60_06060 ENOG4105CFP Peptidase U32 ACX60_06065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACX60_06070 ENOG4105JAB phenazine biosynthesis protein, phzf family ACX60_06075 ENOG4105DP0 ferredoxin-NADP reductase ACX60_06080 ENOG4108R96 Methyltransferase, YaeB family ACX60_06090 ENOG4107QHF type ii secretion system protein e ACX60_06100 ENOG4105XJC Two component transcriptional regulator (Winged helix family ACX60_06105 ENOG4105DHQ Histidine kinase ACX60_06115 ENOG4105M6F mutator MutT protein ACX60_06125 ENOG4105BZ4 penicillin-binding protein ACX60_06130 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ACX60_06135 ENOG4105VUT cytoplasmic protein ACX60_06140 ENOG4108I0Q anthranilate phosphoribosyltransferase ACX60_06145 ENOG4105CK2 sodium dicarboxylate symporter ACX60_06150 ENOG4105C1G acyl-Coa dehydrogenase ACX60_06155 ENOG4105NIV Esterase ACX60_06160 ENOG4105CQC Prephenate dehydratase ACX60_06165 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ACX60_06175 ENOG4105CIN aminoacyl-histidine dipeptidase ACX60_06195 ENOG4105E0Y RtcB Protein ACX60_06200 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) ACX60_06205 ENOG4105CYB regulatoR ACX60_06235 ENOG4105M08 Membrane ACX60_06240 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ACX60_06250 ENOG4105VEQ Cold shock protein ACX60_06255 ENOG4105C1J atp-dependent rna helicase ACX60_06265 ENOG41069NU Nitroreductase ACX60_06300 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ACX60_06315 ENOG4105C5I Dehydrogenase ACX60_06320 ENOG4105ERG peptidase m48, ste24p ACX60_06325 ENOG4105KTH gatB Yqey ACX60_06330 ENOG4105VCC 30S ribosomal protein S21 ACX60_06355 ENOG4105D9P serine threonine protein kinase ACX60_06380 ENOG4105EVZ LysR family transcriptional regulator ACX60_06385 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ACX60_06390 ENOG4105C26 Dehydrogenase ACX60_06425 ENOG4105H4F exported protein ACX60_06455 ENOG4105D6U Sodium Glutamate Symporter ACX60_06465 ENOG4105JXH GntR family transcriptional regulator ACX60_06515 ENOG4105CSH Transporter ACX60_06550 ENOG4105F1S paraquat-inducible protein a ACX60_06555 ENOG4105DY2 Paraquat-inducible protein b ACX60_06600 ENOG4105CK2 sodium dicarboxylate symporter ACX60_06610 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ACX60_06615 ENOG4108UMI ABC transporter, permease ACX60_06620 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ACX60_06630 ENOG4105C12 Phosphoribosylglycinamide synthetase ACX60_06635 ENOG4105DC1 bifunctional purine biosynthesis protein purh ACX60_06640 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ACX60_06690 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ACX60_06695 ENOG4105CDU Replicative dna helicase ACX60_06720 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) ACX60_06725 ENOG4105CCU oxidase (Subunit III) ACX60_06730 ENOG4105BZ9 Cytochrome C oxidase, subunit I ACX60_06735 ENOG4105E2S oxidase) subunit II ACX60_06760 ENOG4107BJW polysaccharide deacetylase ACX60_06765 ENOG4105CND Glycosyl transferase, family 2 ACX60_06770 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD ACX60_06780 ENOG4105DEN Luciferase family ACX60_06795 ENOG4105CC0 LysR family Transcriptional regulator ACX60_06810 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ACX60_06825 ENOG4105C1G acyl-Coa dehydrogenase ACX60_06835 ENOG4108MEJ flavin reductase domain protein ACX60_06840 ENOG4105D06 uba thif-type nad fad binding protein ACX60_06850 ENOG4105KRF dihydroneopterin aldolase ACX60_06860 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ACX60_06865 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) ACX60_06870 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) ACX60_06875 ENOG4105C08 Histidine kinase ACX60_06880 ENOG4105EEX Two component transcriptional regulator (Winged helix family ACX60_06885 ENOG4105CFQ glutamine synthetase ACX60_06900 ENOG4107S74 Lysophospholipid transporter LplT ACX60_06905 ENOG4105CFU surface antigen ACX60_06920 ENOG4107QIJ Aconitate hydratase 2 ACX60_06930 ENOG4105EYW Ion transport protein ACX60_06935 ENOG4105F27 Major Facilitator ACX60_06950 ENOG4105DZ2 Transcriptional regulator ACX60_06985 ENOG4105K8N protein family UPF0079, ATPase ACX60_06990 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ACX60_07000 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ACX60_07005 ENOG4108TZV Membrane ACX60_07010 ENOG4108RCM Nitroreductase ACX60_07035 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ACX60_07040 ENOG4107FQ9 ethanolamine ammonia-lyase ACX60_07045 ENOG4105CPD ethanolamine ammonia-lyase ACX60_07050 ENOG4107R55 ethanolamine transporter ACX60_07060 ENOG4107RR1 TRANSCRIPTIONal ACX60_07070 ENOG4105C0A alcohol dehydrogenase ACX60_07075 ENOG4107QUV Domain protein ACX60_07100 ENOG4105CD8 aminopeptidase N ACX60_07115 ENOG4108D1K outer membrane usher protein ACX60_07140 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) ACX60_07145 ENOG4105EW9 transcriptional regulator AsnC family ACX60_07155 ENOG4105R8C Transcriptional regulator ACX60_07165 ENOG4105CUY Mechanosensitive ion channel ACX60_07195 ENOG4105CNM Receptor ACX60_07215 ENOG4105C5H ABC transporter ACX60_07220 ENOG41081QV Universal stress protein ACX60_07240 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic ACX60_07250 ENOG4105DKK Benzoate ACX60_07255 ENOG4105EW9 transcriptional regulator AsnC family ACX60_07260 ENOG4108NIW Leucine export protein LeuE ACX60_07265 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ACX60_07270 ENOG4105C5Q Transcriptional regulator ACX60_07280 ENOG4105CHU acetyl-coa acetyltransferase ACX60_07285 ENOG4105CHR reductase ACX60_07310 ENOG4107QMP dna polymerase iii subunits gamma and tau ACX60_07315 ENOG4105HSS phospholipase C ACX60_07325 ENOG4105C0A alcohol dehydrogenase ACX60_07355 ENOG4105CBC glutamate synthase ACX60_07500 ENOG4105WXW Antirepressor ACX60_07700 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ACX60_07715 ENOG4105D8G Major Facilitator superfamily ACX60_07725 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ACX60_07730 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ACX60_07750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACX60_07760 ENOG4107QZF nitrite reductase NADPH large subunit ACX60_07765 ENOG4108IFG nitrite reductase, (NAD(P)H) ACX60_07800 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ACX60_07805 ENOG4105CVM Molybdenum cofactor synthesis domain protein ACX60_07815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACX60_07820 ENOG4105T38 integral membrane protein ACX60_07840 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) ACX60_07845 ENOG4105CMR udp-glucose 4-epimerase ACX60_07900 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ACX60_07905 ENOG4105CUX Signal transduction histidine kinase ACX60_07925 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ACX60_07930 ENOG4105KNE Phosphatidate cytidylyltransferase ACX60_07940 ENOG4105DZP Membrane-associated zinc metalloprotease ACX60_07945 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ACX60_07965 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ACX60_07975 ENOG4105Y3E Modulates RecA activity (By similarity) ACX60_07985 ENOG4105VEJ Heat shock protein ACX60_07990 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 ACX60_08015 ENOG4105F7P transcriptional regulator AsnC family ACX60_08025 ENOG4105C85 amino acid ACX60_08040 ENOG4105CHH sulfate transporter ACX60_08045 ENOG4108RAV Conserved protein ACX60_08050 ENOG4105D8V Glucose sorbosone dehydrogenase ACX60_08060 ENOG4105BZU Histidine kinase ACX60_08075 ENOG4105DM4 PTS System ACX60_08080 ENOG4105DE4 1-phosphofructokinase ACX60_08085 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ACX60_08110 ENOG4105CWM branched-chain amino acid transport system II carrier protein ACX60_08115 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ACX60_08120 ENOG4105CC0 LysR family Transcriptional regulator ACX60_08130 ENOG4105M2J Glutaredoxin ACX60_08135 ENOG4105C8Y Acetylornithine aminotransferase ACX60_08140 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ACX60_08165 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ACX60_08175 ENOG41068P6 UPF0319 protein ACX60_08195 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ACX60_08200 ENOG4105C4M (Ubiquinol oxidase) subunit I ACX60_08210 ENOG4105PV3 Inner membrane protein yqiJ ACX60_08225 ENOG4105E0K tonB-dependent siderophore receptor ACX60_08235 ENOG4105HDD phospholipase ACX60_08240 ENOG4105CZN Potassium uptake protein ACX60_08250 ENOG4105C7B Threonine dehydratase ACX60_08280 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) ACX60_08285 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACX60_08295 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ACX60_08310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACX60_08355 ENOG4107VMU Membrane ACX60_08360 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ACX60_08370 ENOG4107QP7 CoA-transferase subunit A ACX60_08375 ENOG4107QNJ CoA-transferase subunit B ACX60_08380 ENOG4105CHU acetyl-coa acetyltransferase ACX60_08385 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase ACX60_08390 ENOG4105F2Z 3-oxoadipate enol-lactonase ACX60_08395 ENOG4105D2S major facilitator superfamily ACX60_08400 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase ACX60_08405 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta ACX60_08410 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha ACX60_08415 ENOG4105FF2 Type I DHQase ACX60_08420 ENOG4106JPM 3-dehydroshikimate dehydratase ACX60_08425 ENOG4105TW1 Carbohydrate-selective porin OprB ACX60_08430 ENOG4105DZG Dehydrogenase ACX60_08440 ENOG4105MD1 YeeE YedE family protein ACX60_08455 ENOG4107HP6 Transcriptional regulator ACX60_08460 ENOG4108PTX LysR family Transcriptional regulator ACX60_08465 ENOG4105C1G acyl-Coa dehydrogenase ACX60_08490 ENOG4105DNH Major Facilitator ACX60_08500 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ACX60_08520 ENOG4105FUY alpha subunit ACX60_08530 ENOG4105CHR reductase ACX60_08550 ENOG4105F11 amine oxidase ACX60_08560 ENOG4105C26 Dehydrogenase ACX60_08570 ENOG4105F2Z 3-oxoadipate enol-lactonase ACX60_08575 ENOG4105CHU acetyl-coa acetyltransferase ACX60_08580 ENOG4107QNJ CoA-transferase subunit B ACX60_08585 ENOG4107QP7 CoA-transferase subunit A ACX60_08595 ENOG4105NN7 muconolactone delta-isomerase ACX60_08600 ENOG4105DTQ mandelate racemase muconate lactonizing ACX60_08605 ENOG4108KB2 LysR family Transcriptional regulator ACX60_08615 ENOG4107EJG GntR family transcriptional regulator ACX60_08635 ENOG4105CZJ Aldehyde dehydrogenase ACX60_08650 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACX60_08660 ENOG4105NAE bifunctional deaminase-reductase domain protein ACX60_08670 ENOG4108Z6Z Transcriptional regulator ACX60_08695 ENOG4107Z3H Transcriptional regulator, TetR family ACX60_08700 ENOG4108PTX LysR family Transcriptional regulator ACX60_08705 ENOG41061TZ Short-chain dehydrogenase reductase Sdr ACX60_08710 ENOG41061TZ Short-chain dehydrogenase reductase Sdr ACX60_08715 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr ACX60_08725 ENOG4105CSU acyl-Coa dehydrogenase ACX60_08735 ENOG4105CEY Amp-dependent synthetase and ligase ACX60_08820 ENOG4105FDP GntR family transcriptional regulator ACX60_08835 ENOG4106KR7 LysR family Transcriptional regulator ACX60_08850 ENOG4105CW7 secretion protein, HlyD family ACX60_08865 ENOG4105CZJ Aldehyde dehydrogenase ACX60_08870 ENOG4105C01 Dihydroxy-acid dehydratase ACX60_08880 ENOG4105DDW LysR family Transcriptional regulator ACX60_08885 ENOG4105EXW epimerase dehydratase ACX60_08895 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ACX60_08900 ENOG4105CF7 AraC family transcriptional regulator ACX60_08905 ENOG4105DQ4 alcohol dehydrogenase ACX60_08915 ENOG4105EHG Permease protein ACX60_08920 ENOG4105E0A ABC, transporter ACX60_08940 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ACX60_09015 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) ACX60_09050 ENOG4105M03 Domain of unknown function (DUF955) ACX60_09100 ENOG4108R6W Transcriptional regulator, ARAC family ACX60_09105 ENOG4108821 RND type efflux pump ACX60_09115 ENOG4105E0F Histidine kinase ACX60_09120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ACX60_09125 ENOG4105C1P efflux transporter, rnd family, mfp subunit ACX60_09130 ENOG4105BZS acriflavin resistance protein ACX60_09175 ENOG4105CHR reductase ACX60_09185 ENOG4105D2S major facilitator superfamily ACX60_09190 ENOG4105CF7 AraC family transcriptional regulator ACX60_09195 ENOG4105DTD Dehydrogenase ACX60_09200 ENOG4105CY2 Citrate transporter ACX60_09210 ENOG4108IND Tetr family transcriptional regulator ACX60_09230 ENOG4108M0I Transcriptional regulator ACX60_09245 ENOG4105CRW Short chain fatty acid transporter ACX60_09250 ENOG4105CHU acetyl-coa acetyltransferase ACX60_09260 ENOG4107YNJ LysR family Transcriptional regulator ACX60_09275 ENOG4108IJ0 Aspartate ammonia-lyase ACX60_09285 ENOG4105CSH Transporter ACX60_09305 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ACX60_09310 ENOG4106FTQ Taurine ABC transporter, periplasmic ACX60_09325 ENOG4105FDP GntR family transcriptional regulator ACX60_09335 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ACX60_09340 ENOG4105KVH Transcriptional regulator ACX60_09345 ENOG4105UEI Transcriptional Regulator AraC Family ACX60_09360 ENOG4108VCT Sulfite exporter TauE/SafE ACX60_09370 ENOG4107S76 domain protein ACX60_09380 ENOG4105FFC UPF0187 protein ACX60_09390 ENOG4105CHR reductase ACX60_09405 ENOG4105CPP Dehydrogenase, E1 component ACX60_09410 ENOG4107R0V Pyruvate dehydrogenase ACX60_09415 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ACX60_09430 ENOG4105BZU Histidine kinase ACX60_09440 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ACX60_09445 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ACX60_09455 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ACX60_09485 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) ACX60_09490 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ACX60_09505 ENOG4105C28 cystathionine ACX60_09515 ENOG4105F2W methyltransferase ACX60_09545 ENOG4105K59 histidine triad (HIT) protein ACX60_09570 ENOG4107QWP ABC-2 type transporter ACX60_09575 ENOG4107QWP ABC-2 type transporter ACX60_09580 ENOG4105CJ1 ABC, transporter ACX60_09595 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ACX60_09600 ENOG4105CNM Receptor ACX60_09620 ENOG4107TSN permease ACX60_09625 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ACX60_09640 ENOG4107TB6 phosphoglycerate mutase ACX60_09645 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) ACX60_09650 ENOG4108YZT Adenosylcobinamide kinase ACX60_09660 ENOG4107VXZ Hydrolase ACX60_09690 ENOG4105JSC dimethylmenaquinone methyltransferase ACX60_09700 ENOG4105DJU Siderophore biosynthesis protein ACX60_09705 ENOG4105DUU IucA IucC family protein ACX60_09710 ENOG4105C0R drug resistance transporter emrb qaca subfamily ACX60_09725 ENOG4108Z66 YbaK ebsC protein ACX60_09740 ENOG4105C1G acyl-Coa dehydrogenase ACX60_09745 ENOG4105C1G acyl-Coa dehydrogenase ACX60_09750 ENOG4105EEF Alkane 1-monooxygenase ACX60_09755 ENOG4105E7U AraC family transcriptional regulator ACX60_09765 ENOG4105K70 DNA-binding protein ACX60_09780 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family ACX60_09790 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ACX60_09795 ENOG4108Z4V iron-sulfur cluster assembly ACX60_09810 ENOG4108ZIT Ferredoxin, 2FE-2S ACX60_09815 ENOG4105F8J Adenylate Guanylate cyclase ACX60_09825 ENOG4108JA2 transcriptioN-repair coupling factor ACX60_09845 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) ACX60_09850 ENOG4105K4T epimerase ACX60_09865 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase ACX60_09885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ACX60_09895 ENOG4105DGW oligopeptidase A ACX60_09930 ENOG4105SG9 biopolymer transport protein, ExbD ACX60_09940 ENOG4107QP3 malate synthase g ACX60_10050 ENOG4105EFC phage portal protein HK97 family ACX60_10130 ENOG4105CDU Replicative dna helicase ACX60_10205 ENOG4105D6Z AFG1 family ATPase ACX60_10215 ENOG4107RN6 Monooxygenase ACX60_10235 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) ACX60_10240 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ACX60_10255 ENOG4108Z6B deaminase ACX60_10275 ENOG4108RTD type II secretion system protein K ACX60_10300 ENOG4105F8V Hydrolase, tatD family ACX60_10310 ENOG4107QRG dna polymerase iii ACX60_10320 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) ACX60_10325 ENOG4105BZ1 (ABC) transporter ACX60_10340 ENOG4105FA0 parb-like partition protein ACX60_10345 ENOG4107QJE Chromosome Partitioning Protein ACX60_10355 ENOG4108S0S Nucleotidyl transferase ACX60_10360 ENOG4105EHM Aminoglycoside phosphotransferase ACX60_10365 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) ACX60_10370 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) ACX60_10375 ENOG4105D2N Aldolase ACX60_10395 ENOG4108UHJ MAF-like protein ACX60_10400 ENOG4105EZE Cupin 4 family protein ACX60_10410 ENOG41080HT Transcriptional regulator, arsr family ACX60_10420 ENOG4105XPP Protein of unknown function (DUF1275) ACX60_10425 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme ACX60_10430 ENOG4105BZ1 (ABC) transporter ACX60_10440 ENOG4108ZX5 transcriptional regulator ACX60_10450 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ACX60_10455 ENOG4105CK7 Sodium proline symporter ACX60_10460 ENOG4105EW9 transcriptional regulator AsnC family ACX60_10465 ENOG4105C26 Dehydrogenase ACX60_10470 ENOG4105YGK Pfam:UPF0157 ACX60_10485 ENOG4108T58 Mg2 transport protein CorA ACX60_10495 ENOG4108YYC ycei family ACX60_10505 ENOG4105CV1 Transketolase (EC 2.2.1.1) ACX60_10530 ENOG4108HWY Beta-lactamase ACX60_10550 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ACX60_10555 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ACX60_10575 ENOG4105X0I Fimbrial ACX60_10580 ENOG4105GQR Chaperone ACX60_10605 ENOG4108IPJ Membrane ACX60_10615 ENOG4105ETS cytosine purines uracil thiamine allantoin ACX60_10625 ENOG4105CC0 LysR family Transcriptional regulator ACX60_10645 ENOG41067SE Tetr family transcriptional regulator ACX60_10660 ENOG4105EW9 transcriptional regulator AsnC family ACX60_10670 ENOG4105CDA abc transporter atp-binding protein ACX60_10675 ENOG4105DRP amino acid AbC transporter ACX60_10680 ENOG4105EAD ABC transporter ACX60_10695 ENOG4107T8P acyl-Coa dehydrogenase ACX60_10710 ENOG4105D01 (LipO)protein ACX60_10715 ENOG4105D01 (LipO)protein ACX60_10720 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ACX60_10725 ENOG4108UMI ABC transporter, permease ACX60_10730 ENOG4105C3G gtp-binding protein ACX60_10755 ENOG4108UMN azlc family ACX60_10760 ENOG4105ZED uncharacterized protein ygaH ACX60_10790 ENOG4105E7U AraC family transcriptional regulator ACX60_10795 ENOG4108V06 Glutathione peroxidase ACX60_10805 ENOG4105CHM Aminotransferase ACX60_10810 ENOG4105CK2 sodium dicarboxylate symporter ACX60_10820 ENOG4105C0B DNA polymerase III (alpha subunit) ACX60_10845 ENOG4108JU3 Alkyl hydroperoxide reductase ACX60_10860 ENOG4108KB2 LysR family Transcriptional regulator ACX60_10865 ENOG4105D6J arsenicaL-resistance protein ACX60_10870 ENOG41082YX Transcriptional regulator, arsr family ACX60_10885 ENOG4105CPN adenine deaminase ACX60_10895 ENOG4105CBN LysR family transcriptional regulator ACX60_10905 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease ACX60_10915 ENOG4105E2B Taurine dioxygenase ACX60_10920 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ACX60_10925 ENOG4108IY8 ABC, transporter ACX60_10930 ENOG4106FTQ Taurine ABC transporter, periplasmic ACX60_10940 ENOG4105C54 Major Facilitator superfamily ACX60_10960 ENOG4105C4M (Ubiquinol oxidase) subunit I ACX60_10965 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ACX60_10975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACX60_10980 ENOG4108K70 Transcriptional regulator ACX60_10995 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ACX60_11000 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase ACX60_11015 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) ACX60_11020 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase ACX60_11030 ENOG4105ETT transcriptional Regulator, LysR family ACX60_11040 ENOG4105DXI Major Facilitator superfamily ACX60_11055 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACX60_11060 ENOG41067MG lrgb family ACX60_11065 ENOG4105VAW lrga family ACX60_11070 ENOG4105CMU LysR family (Transcriptional regulator ACX60_11075 ENOG4108SHQ Glutathione S-transferase ACX60_11080 ENOG4105CYM Glutathione S-transferase ACX60_11085 ENOG4105CBN LysR family transcriptional regulator ACX60_11090 ENOG4105CHR reductase ACX60_11100 ENOG4105D7W serine acetyltransferase ACX60_11105 ENOG4105ESN nucleotide-binding protein ACX60_11110 ENOG4105C9B Cysteine desulfurase ACX60_11120 ENOG4105EXG Transcriptional regulator ACX60_11125 ENOG4105CT1 (ABC) transporter ACX60_11130 ENOG4107RP9 extracellular solute-binding protein, family 3 ACX60_11140 ENOG4108HW4 amino acid AbC transporter ACX60_11145 ENOG4105EAD ABC transporter ACX60_11155 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase ACX60_11160 ENOG4105BZU Histidine kinase ACX60_11170 ENOG4105EW9 transcriptional regulator AsnC family ACX60_11200 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ACX60_11250 ENOG4105HEI LysR family (Transcriptional regulator ACX60_11270 ENOG4105CEY Amp-dependent synthetase and ligase ACX60_11275 ENOG4105R8C Transcriptional regulator ACX60_11280 ENOG4105C1G acyl-Coa dehydrogenase ACX60_11285 ENOG4107QX3 carboxylase ACX60_11290 ENOG4105E39 Enoyl-CoA hydratase ACX60_11305 ENOG4105CC0 LysR family Transcriptional regulator ACX60_11320 ENOG4108NIW Leucine export protein LeuE ACX60_11325 ENOG4108KAZ Involved in phosphonate degradation (By similarity) ACX60_11330 ENOG4107STF Involved in phosphonate degradation (By similarity) ACX60_11340 ENOG4107RCV ABC transporter, permease ACX60_11345 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ACX60_11350 ENOG4105C4Y ABC transporter ACX60_11365 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase ACX60_11370 ENOG4107HP6 Transcriptional regulator ACX60_11380 ENOG4105HEI LysR family (Transcriptional regulator ACX60_11385 ENOG4105CPW cytochrome b561 ACX60_11390 ENOG4107VGR Catalase ACX60_11420 ENOG4107YAU phenylacetic acid degradation protein ACX60_11425 ENOG4108Z0R Transferase ACX60_11430 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein ACX60_11435 ENOG4105DZS Phenylacetate-CoA ligase ACX60_11440 ENOG4105CHU acetyl-coa acetyltransferase ACX60_11445 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ACX60_11450 ENOG4108UKI Enoyl-CoA hydratase ACX60_11455 ENOG4105E39 Enoyl-CoA hydratase ACX60_11460 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ACX60_11465 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit ACX60_11470 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit ACX60_11475 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit ACX60_11480 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit ACX60_11485 ENOG4105DXM phenylacetic acid degradation protein ACX60_11490 ENOG4105EJQ L-serine dehydratase ACX60_11495 ENOG4107QTZ amino acid ACX60_11500 ENOG4105CZJ Aldehyde dehydrogenase ACX60_11525 ENOG4105MWK D-amino acid dehydrogenase, small subunit ACX60_11545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACX60_11555 ENOG4108Z4X TRANSCRIPTIONal ACX60_11565 ENOG4105WPN DNA integration recombination invertion protein ACX60_11580 ENOG4105DJ2 Major Facilitator Superfamily ACX60_11585 ENOG4107Y2X deaminase ACX60_11595 ENOG4105EMY transcriptional regulator ACX60_11625 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACX60_11635 ENOG4105UYK outer membrane protein a ACX60_11690 ENOG4105E6M Sulphatase-modifying factor protein ACX60_11720 ENOG4108HW3 (ABC) transporter ACX60_11730 ENOG4105MRR Transcriptional regulator (By similarity) ACX60_11750 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF ACX60_11755 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ACX60_11770 ENOG4105E2A Dehydrogenase ACX60_11780 ENOG4105R8C Transcriptional regulator ACX60_11790 ENOG4107R4J Chloride channel ACX60_11795 ENOG4108JIK carboxylase ACX60_11815 ENOG4105C5A transporter ACX60_11820 ENOG4108WAV Transcriptional regulator ACX60_11850 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) ACX60_11870 ENOG4105D2S major facilitator superfamily ACX60_11885 ENOG4107QUT magnesium and cobalt transport protein CorA ACX60_11890 ENOG4105D1S lipid A biosynthesis ACX60_11895 ENOG4105BZU Histidine kinase ACX60_11900 ENOG4107AQZ Membrane ACX60_11920 ENOG4108Z4U Ferredoxin ACX60_11960 ENOG4105DFG type I secretion outer membrane protein ACX60_11965 ENOG4108IUZ ABC transporter ACX60_11970 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA ACX60_11980 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ACX60_11985 ENOG4105C2X Arabinose 5-phosphate isomerase ACX60_12020 ENOG4107YPT transcriptional regulator ACX60_12045 ENOG4105II7 pyrroline-5-carboxylate reductase ACX60_12055 ENOG4105VEQ Cold shock protein ACX60_12060 ENOG410829K Lysine exporter protein (Lyse ygga) ACX60_12095 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ACX60_12150 ENOG4108KB2 LysR family Transcriptional regulator ACX60_12155 ENOG4105FUY alpha subunit ACX60_12160 ENOG4108UKV benzoate 1,2-dioxygenase ACX60_12165 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein ACX60_12170 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase ACX60_12175 ENOG4105DKK Benzoate ACX60_12180 ENOG4105D2S major facilitator superfamily ACX60_12195 ENOG4105CQ7 ATP-dependent helicase ACX60_12200 ENOG4105D3R alkyl hydroperoxide reductase ACX60_12210 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) ACX60_12220 ENOG4108JU3 Alkyl hydroperoxide reductase ACX60_12230 ENOG4108K3A Glutathione S-transferase ACX60_12240 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ACX60_12245 ENOG4108TGY Glutathione S-transferase ACX60_12255 ENOG4108ZG0 Ompa motb domain protein ACX60_12260 ENOG4105CD3 dihydroorotase ACX60_12290 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ACX60_12305 ENOG4108UKZ OsmC family ACX60_12310 ENOG4107RYR Transcriptional regulator, Crp Fnr family ACX60_12315 ENOG4105CPC Aldo Keto reductase ACX60_12330 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ACX60_12340 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ACX60_12350 ENOG4105DFP Integrase ACX60_12485 ENOG41090AG Bacteriophage protein ACX60_12510 ENOG4107ZQ5 Phage-associated protein, HI1409 family ACX60_12595 ENOG4105W7J DNA binding ACX60_12600 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ACX60_12650 ENOG4105CFH Aspartokinase ACX60_12660 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ACX60_12670 ENOG4105CPW cytochrome b561 ACX60_12675 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) ACX60_12680 ENOG4105C7N Xanthine uracil vitamin C permease ACX60_12690 ENOG4105F95 Monooxygenase ACX60_12725 ENOG4105F95 Monooxygenase ACX60_12730 ENOG4105JQZ Methyltransferase ACX60_12740 ENOG4107RN6 Monooxygenase ACX60_12760 ENOG4105EPF Outer membrane porin ACX60_12765 ENOG4105D2S major facilitator superfamily ACX60_12775 ENOG4105E3J oxidoreductase ACX60_12790 ENOG4108SC4 )-transporter ACX60_12795 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase ACX60_12810 ENOG4105C1G acyl-Coa dehydrogenase ACX60_12815 ENOG4105EPF Outer membrane porin ACX60_12820 ENOG4105NI3 Protein of unknown function (DUF3237) ACX60_12835 ENOG4105JXH GntR family transcriptional regulator ACX60_12840 ENOG4105CZJ Aldehyde dehydrogenase ACX60_12850 ENOG4105EQX glucarate dehydratase ACX60_12855 ENOG4105DJB Major Facilitator Superfamily ACX60_12860 ENOG4105CTX dehydratase ACX60_12865 ENOG4105DJP Membrane ACX60_12870 ENOG4108ZX5 transcriptional regulator ACX60_12875 ENOG4107RGH Aldehyde dehydrogenase ACX60_12895 ENOG4105C85 amino acid ACX60_12915 ENOG4105C26 Dehydrogenase ACX60_12935 ENOG4105CUB amino acid ACX60_12945 ENOG4105C85 amino acid ACX60_12970 ENOG4105D01 (LipO)protein ACX60_12990 ENOG4105CR8 Transcriptional regulator ACX60_12995 ENOG4105MWK D-amino acid dehydrogenase, small subunit ACX60_13000 ENOG4105M4H endoribonuclease L-psp ACX60_13040 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ACX60_13065 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) ACX60_13085 ENOG4108JQ5 ABC transporter ACX60_13090 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component ACX60_13095 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component ACX60_13105 ENOG4105E9H Lytic Murein transglycosylase ACX60_13105 ENOG4105E9H Lytic Murein transglycosylase ACX60_13110 ENOG4107RZZ dna polymerase iii epsilon subunit ACX60_13120 ENOG4105E09 nadh pyrophosphatase ACX60_13130 ENOG4105W4M Transport-associated protein ACX60_13140 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ACX60_13150 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) ACX60_13155 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ACX60_13175 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ACX60_13180 ENOG4105D0A hydroxylase ACX60_13185 ENOG4107RAQ aminopeptidase ACX60_13215 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ACX60_13240 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b ACX60_13250 ENOG4105D82 Glutamate dehydrogenase ACX60_13255 ENOG4108R3D Electron transport complex ACX60_13260 ENOG4105CSM endonuclease III ACX60_13280 ENOG4105CJN penicillin-binding protein ACX60_13285 ENOG4106H78 methyltransferase ACX60_13300 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) ACX60_13310 ENOG4105CQM Urea amidohydrolase subunit alpha ACX60_13345 ENOG4107RET Isocitrate lyase ACX60_13355 ENOG4105C37 (CBS) domain ACX60_13360 ENOG4105D4T Citrate transporter ACX60_13375 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) ACX60_13385 ENOG4108MRJ ACX60_13405 ENOG4105VCQ rubredoxin ACX60_13410 ENOG4107QZF nitrite reductase NADPH large subunit ACX60_13420 ENOG4105C5Q Transcriptional regulator ACX60_13440 ENOG4107U91 Rhomboid family ACX60_13445 ENOG4105CV6 ABC transporter, permease ACX60_13450 ENOG4108I0Y (ABC) transporter ACX60_13455 ENOG4108UJV acyl-CoA thioesterase i ACX60_13475 ENOG4107RNH Outer membrane receptor FepA ACX60_13490 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) ACX60_13495 ENOG4105E6M Sulphatase-modifying factor protein ACX60_13515 ENOG4105CJ3 phosphate transporter ACX60_13520 ENOG4105C3R Methionine synthase ACX60_13535 ENOG4105CSP Major Facilitator Superfamily ACX60_13545 ENOG4108PZW LysR family Transcriptional regulator ACX60_13555 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ACX60_13565 ENOG4105EU0 Major facilitator Superfamily ACX60_13570 ENOG4108R6W Transcriptional regulator, ARAC family ACX60_13575 ENOG4105CSV Glutaminase ACX60_13580 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ACX60_13585 ENOG4105CSH Transporter ACX60_13595 ENOG4105C7K acetolactate synthase ACX60_13610 ENOG4105CHR reductase ACX60_13615 ENOG4108MXF Alpha Beta Hydrolase ACX60_13625 ENOG4105DJB Major Facilitator Superfamily ACX60_13630 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase ACX60_13640 ENOG4105CHR reductase ACX60_13660 ENOG41069M3 Transcriptional regulator ACX60_13675 ENOG4106YT9 Enoyl-CoA hydratase ACX60_13685 ENOG4105CND Glycosyl transferase, family 2 ACX60_13690 ENOG4107BJW polysaccharide deacetylase ACX60_13700 ENOG4108VWS Yaeq family ACX60_13710 ENOG4105CKI cobalamin synthesis protein ACX60_13730 ENOG4105C94 Transporter ACX60_13735 ENOG4105C94 Transporter ACX60_13740 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) ACX60_13765 ENOG4107QK5 Homocysteine s-methyltransferase ACX60_13770 ENOG4105D5Q Arginine ornithine antiporter ACX60_13795 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACX60_13800 ENOG4105C54 Major Facilitator superfamily ACX60_13835 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ACX60_13840 ENOG4105C0R drug resistance transporter emrb qaca subfamily ACX60_13845 ENOG4105CW7 secretion protein, HlyD family ACX60_13850 ENOG4108VUY thioesterase Superfamily protein ACX60_13855 ENOG4105D52 delta-aminolevulinic acid dehydratase ACX60_13860 ENOG4105MWK D-amino acid dehydrogenase, small subunit ACX60_13865 ENOG4105ECP epimerase ACX60_13885 ENOG4107RH8 nuclease SbcCD subunit D ACX60_13890 ENOG4105EYH Exonuclease ACX60_13895 ENOG4105DFA alanine racemase domain protein ACX60_13900 ENOG4105CZX twitching motility protein ACX60_13905 ENOG4105CZX twitching motility protein ACX60_13910 ENOG41090R7 Ferric uptake ACX60_13920 ENOG4105VDB UPF0125 protein ACX60_13935 ENOG4105E7A Glutamine amidotransferase ACX60_13950 ENOG4107QKV phosphomannomutase ACX60_13960 ENOG4105C4R Atp-dependent dna helicase ACX60_13965 ENOG4108ZG0 Ompa motb domain protein ACX60_13970 ENOG4106HNH Acyl-transferase ACX60_13985 ENOG4107QMS site-determining protein ACX60_14005 ENOG4105CNU cell division protein FtsK ACX60_14010 ENOG4105C3M thioredoxin reductase ACX60_14015 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) ACX60_14025 ENOG4105KEG ribosomal-protein-alanine acetyltransferase ACX60_14070 ENOG4108YXA Membrane ACX60_14075 ENOG4105EUB pirin domain protein ACX60_14085 ENOG4105C4K Nad synthetase ACX60_14100 ENOG4105E3J oxidoreductase ACX60_14105 ENOG4105C26 Dehydrogenase ACX60_14110 ENOG4105DVW rieske (2Fe-2S) ACX60_14120 ENOG4105C94 Transporter ACX60_14125 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ACX60_14130 ENOG4105EJC lysr family transcriptional regulator ACX60_14145 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ACX60_14165 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ACX60_14170 ENOG4105C34 Pseudouridine synthase ACX60_14175 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ACX60_14180 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ACX60_14195 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) ACX60_14225 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ACX60_14255 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ACX60_14265 ENOG4105DWF phosphomethylpyrimidine kinase ACX60_14270 ENOG4109066 lysm domain bon superfamily protein ACX60_14280 ENOG4105CHR reductase ACX60_14285 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ACX60_14295 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ACX60_14300 ENOG4108BPE -transporting atpase ACX60_14305 ENOG4107RTD sua5 ycio yrdc ywlc family protein ACX60_14310 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) ACX60_14315 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) ACX60_14320 ENOG4105FE9 pseudouridine synthase ACX60_14330 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ACX60_14335 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ACX60_14345 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ACX60_14350 ENOG4108K4C ec 3.1.3.12 ACX60_14355 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase ACX60_14360 ENOG4106UW1 Major Facilitator superfamily ACX60_14380 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) ACX60_14390 ENOG4105HF0 Membrane ACX60_14405 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ACX60_14415 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) ACX60_14465 ENOG4105D1F ATP-binding protein ACX60_14475 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ACX60_14505 ENOG4105K6H D-cysteine desulfhydrase ACX60_14510 ENOG4105CBX hi0933 family ACX60_14535 ENOG4105DP0 ferredoxin-NADP reductase ACX60_14540 ENOG4105DUM transcriptional regulator, lysR family ACX60_14565 ENOG4105C8S subunit m ACX60_14570 ENOG4105D65 subunit l ACX60_14580 ENOG4107UFS subunit j ACX60_14595 ENOG4108IEH NADH dehydrogenase subunit g ACX60_14600 ENOG4107QIZ NADH dehydrogenase ACX60_14605 ENOG4105GKE subunit e ACX60_14625 ENOG4105BZU Histidine kinase ACX60_14635 ENOG4105E0F Histidine kinase ACX60_14640 ENOG4107EXC regulatoR ACX60_14645 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACX60_14655 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ACX60_14700 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) ACX60_14705 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ACX60_14715 ENOG4105ETT transcriptional Regulator, LysR family ACX60_14735 ENOG4105CH2 amidohydrolase ACX60_14745 ENOG4106P55 Transcriptional regulator ACX60_14760 ENOG4106P55 Transcriptional regulator ACX60_14765 ENOG4107EFR Flavocytochrome c ACX60_14775 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ACX60_14780 ENOG4107RGD Major Facilitator superfamily ACX60_14785 ENOG4105C1G acyl-Coa dehydrogenase ACX60_14790 ENOG4105ETT transcriptional Regulator, LysR family ACX60_14825 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ACX60_14830 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) ACX60_14835 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ACX60_14855 ENOG4105E3B Multicopper oxidase ACX60_14865 ENOG4108HCJ Hydrolase ACX60_14870 ENOG4105DJV ribulose-phosphate 3-epimerase ACX60_14895 ENOG41072GX Peptidase M22 Glycoprotease ACX60_14900 ENOG4108Z0R Transferase ACX60_14945 ENOG4105CRQ synthase (Component I) ACX60_14955 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ACX60_14960 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ACX60_14965 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ACX60_15035 ENOG4105K56 Transcriptional regulator ACX60_15040 ENOG4108ZHJ Organic hydroperoxide resistance protein ACX60_15045 ENOG4107QHF type ii secretion system protein e ACX60_15065 ENOG4105C2M dna polymerase I ACX60_15070 ENOG4108VIA integral membrane protein ACX60_15075 ENOG4105II7 pyrroline-5-carboxylate reductase ACX60_15080 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ACX60_15090 ENOG4105C9X ppx gppa phosphatase ACX60_15100 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ACX60_15115 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ACX60_15140 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ACX60_15155 ENOG4105W39 Membrane ACX60_15160 ENOG4105CYM Glutathione S-transferase ACX60_15175 ENOG4105CEY Amp-dependent synthetase and ligase ACX60_15180 ENOG4105N42 UPF0307 protein ACX60_15185 ENOG41080Z8 PHOSPHOCARRIER protein ACX60_15205 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ACX60_15210 ENOG4105DJ0 Poly(A) Polymerase ACX60_15215 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein ACX60_15220 ENOG4105DXN mazG family ACX60_15230 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ACX60_15245 ENOG4105C6T cysteine synthase ACX60_15250 ENOG4105BZU Histidine kinase ACX60_15255 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase ACX60_15260 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ACX60_15265 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) ACX60_15280 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ACX60_15285 ENOG4105W8H transhydrogenase (subunit alpha ACX60_15290 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ACX60_15295 ENOG4106UX7 integral membrane protein ACX60_15310 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ACX60_15320 ENOG4107RSM transcriptional regulator ACX60_15325 ENOG4105CUZ uba thif-type nad fad binding protein ACX60_15330 ENOG4107QM5 aconitate hydratase ACX60_15335 ENOG4105F8V Hydrolase, tatD family ACX60_15350 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) ACX60_15390 ENOG4105BZU Histidine kinase ACX60_15400 ENOG4108ZP8 Acetolactate synthase small subunit ACX60_15405 ENOG4105C7K acetolactate synthase ACX60_15430 ENOG4105DJY efflux transporter, rnd family, mfp subunit ACX60_15435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ACX60_15440 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ACX60_15445 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH ACX60_15455 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) ACX60_15460 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ACX60_15470 ENOG4105VW4 glutaredoxin 3 ACX60_15490 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ACX60_15495 ENOG4105C2D reductase ACX60_15505 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ACX60_15535 ENOG4105C84 Histidine ammonia-lyase ACX60_15545 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) ACX60_15550 ENOG4105CEY Amp-dependent synthetase and ligase ACX60_15565 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ACX60_15585 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ACX60_15605 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) ACX60_15625 ENOG4105WVQ Fe-S assembly protein IscX ACX60_15640 ENOG4105CN1 protease ACX60_15655 ENOG4106HB6 Alpha beta hydrolase ACX60_15665 ENOG4105C26 Dehydrogenase ACX60_15670 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ACX60_15675 ENOG4105C6Z Gluconate ACX60_15680 ENOG4108UHU Aldolase ACX60_15685 ENOG4105C01 Dihydroxy-acid dehydratase ACX60_15690 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ACX60_15695 ENOG4108DNC Involved in acetate metabolism (By similarity) ACX60_15700 ENOG4107GFK fumarate ACX60_15720 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ACX60_15730 ENOG4108ESX Receptor ACX60_15740 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ACX60_15750 ENOG4105DWV Homoserine O-trans-acetylase ACX60_15850 ENOG4105CIY formyltetrahydrofolate deformylase ACX60_15860 ENOG4107RGH Aldehyde dehydrogenase ACX60_15865 ENOG4105KDC 50s ribosomal protein l28 ACX60_15870 ENOG4105W0E 50S ribosomal protein L33 ACX60_15875 ENOG4105CKD glutathione-regulated potassium-efflux system protein ACX60_15895 ENOG4105VFU Rna-binding protein ACX60_15900 ENOG4105C4R Atp-dependent dna helicase ACX60_15915 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ACX60_15925 ENOG4105KVH Transcriptional regulator ACX60_15935 ENOG41069P5 Protein slyX homolog ACX60_15940 ENOG4105C5H ABC transporter ACX60_15945 ENOG4105N14 lysine exporter protein LysE YggA ACX60_15950 ENOG4105D1S lipid A biosynthesis ACX60_15960 ENOG4105CK2 sodium dicarboxylate symporter ACX60_16015 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ACX60_16040 ENOG4105DUM transcriptional regulator, lysR family ACX60_16055 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase ACX60_16070 ENOG4108W5M transcriptional regulator ACX60_16085 ENOG4105D29 Helix-turn-helix type 11 domain protein ACX60_16090 ENOG4107XGZ Hydrolase ACX60_16095 ENOG4105EI2 Pseudouridine synthase ACX60_16100 ENOG4105C03 ribonuclease ACX60_16120 ENOG4105CBN LysR family transcriptional regulator ACX60_16130 ENOG4105CSA Coproporphyrinogen iii oxidase ACX60_16140 ENOG4107QI1 Mate efflux family protein ACX60_16150 ENOG4107T8P acyl-Coa dehydrogenase ACX60_16180 ENOG4105BZ8 glutamate synthase ACX60_16190 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) ACX60_16195 ENOG4105C5X domain protein ACX60_16210 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ACX60_16220 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase ACX60_16230 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) ACX60_16235 ENOG4108JU5 Magnesium and cobalt efflux protein ACX60_16240 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ACX60_16245 ENOG4108Z7R Chaperone CsaA ACX60_16255 ENOG4108VAU general secretion pathway protein G ACX60_16260 ENOG4105D7Q type ii secretion system ACX60_16265 ENOG4105C25 Primosomal protein n' ACX60_16270 ENOG4105CKD glutathione-regulated potassium-efflux system protein ACX60_16285 ENOG4105DVC DnaJ domain protein ACX60_16290 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) ACX60_16295 ENOG4107QUT magnesium and cobalt transport protein CorA ACX60_16315 ENOG4107QYX exodeoxyribonuclease v alpha ACX60_16320 ENOG4107QKA exodeoxyribonuclease V beta ACX60_16325 ENOG4105DSY exodeoxyribonuclease V, gamma ACX60_16335 ENOG4105CSR polyphosphate kinase 2 ACX60_16345 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ACX60_16365 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ACX60_16380 ENOG4105D65 subunit l ACX60_16385 ENOG4108ZE9 Monovalent cation H antiporter subunit C ACX60_16390 ENOG4107R4Z monovalent cation h antiporter subunit d ACX60_16395 ENOG4105SC1 monovalent cation H antiporter subunit E ACX60_16400 ENOG4105W4C monovalent cation H antiporter subunit F ACX60_16405 ENOG4105KJM monovalent cation h antiporter subunit g ACX60_16420 ENOG4105CHV Transcription elongation factor NusA ACX60_16440 ENOG4107EJC Preprotein translocase subunit SecG ACX60_16450 ENOG4107QHF type ii secretion system protein e ACX60_16465 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ACX60_16475 ENOG4105C2N RNA methyltransferase TrmH family group 3 ACX60_16490 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ACX60_16500 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ACX60_16530 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ACX60_16535 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase ACX60_16600 ENOG4107ZXU DSBA oxidoreductase ACX60_16615 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ACX60_16630 ENOG4105D3Y Na H antiporter ACX60_16635 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) ACX60_16685 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ACX60_16690 ENOG4105PM1 preprotein translocase subunit SecE ACX60_16730 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ACX60_16735 ENOG4105TV9 FHA Domain-Containing protein ACX60_16740 ENOG4105GVR general secretion pathway protein D ACX60_16755 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS ACX60_16780 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ACX60_16785 ENOG4108NEV two component transcriptional regulator, LytTR family ACX60_16790 ENOG4108HRK Histidine kinase ACX60_16805 ENOG4108UTW Plays a role in the regulation of phosphate uptake ACX60_16810 ENOG4105DFG type I secretion outer membrane protein ACX60_16815 ENOG4108RNG Permease of the drug metabolite transporter ACX60_16840 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ACX60_16845 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ACX60_16850 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) ACX60_16855 ENOG4105CNI cell division protein FtsW ACX60_16870 ENOG4105CE1 Ferrous iron transport protein b ACX60_16880 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACX60_16885 ENOG4105T95 Thiol disulfide interChange protein ACX60_16890 ENOG4105D6E homoserine dehydrogenase ACX60_16900 ENOG41061WM D-Alanyl-D-Alanine ACX60_16910 ENOG4107TUY Histidine kinase ACX60_16915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ACX60_16920 ENOG4105CN1 protease ACX60_16925 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ACX60_16930 ENOG4108K5H permease YjgP YjgQ family protein ACX60_16970 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ACX60_16980 ENOG4105BZU Histidine kinase ACX60_17005 ENOG4105CHH sulfate transporter ACX60_17060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ACX60_17070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ACX60_17080 ENOG41090KI Outer membrane porin ACX60_17085 ENOG4105F0N pyrophosphate phospho-hydrolase ACX60_17100 ENOG4105CEY Amp-dependent synthetase and ligase ACX60_17105 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ACX60_17110 ENOG41079KZ Major Facilitator Superfamily ACX60_17115 ENOG4105EN6 Membrane ACX60_17120 ENOG4105K5B UPF0225 protein ACX60_17125 ENOG4105EE5 Membrane protein terC ACX60_17130 ENOG4108URH decarboxylase ACX60_17135 ENOG4105C0R drug resistance transporter emrb qaca subfamily ACX60_17145 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ACX60_17160 ENOG4105CCT upf0313 protein ACX60_17180 ENOG4105CS1 NAD(P)H quinone oxidoreductase ACX60_17190 ENOG4105C6T cysteine synthase ACX60_17225 ENOG4105Y7M Transcriptional regulator, TetR family ACX60_17260 ENOG4105C79 DNA protecting protein DprA ACX60_17275 ENOG4108IND Tetr family transcriptional regulator ACX60_17280 ENOG4107RTG Major Facilitator superfamily ACX60_17290 ENOG4108V06 Glutathione peroxidase ACX60_17300 ENOG41090VV Protein of unknown function (DUF2846) ACX60_17335 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ACX60_17360 ENOG4105FDK ABC transporter ACX60_17365 ENOG4105FAV ABC, transporter ACX60_17375 ENOG4105EZR dyp-type peroxidase family protein ACX60_17380 ENOG4107R1I NAD-dependent malic enzyme ACX60_17405 ENOG4105EUB pirin domain protein ACX60_17425 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ACX60_17430 ENOG4106MP8 UPF0754 membrane protein ACX60_17435 ENOG4108VBZ doxx family ACX60_17440 ENOG4105DQR SNARE associated Golgi ACX60_17455 ENOG4107QJE Chromosome Partitioning Protein ACX60_17465 ENOG4107PSF BolA-like protein ACX60_17510 ENOG4105C1G acyl-Coa dehydrogenase ACX60_17515 ENOG4107RCI amp-dependent synthetase and ligase ACX60_17535 ENOG4105CSH Transporter ACX60_17540 ENOG4105E39 Enoyl-CoA hydratase ACX60_17545 ENOG4105E39 Enoyl-CoA hydratase ACX60_17550 ENOG4105C1G acyl-Coa dehydrogenase ACX60_17560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ACX60_17565 ENOG4105C26 Dehydrogenase ACX60_17575 ENOG4105C85 amino acid ACX60_17580 ENOG4105C85 amino acid ACX60_17585 ENOG4105M4H endoribonuclease L-psp ACX60_17600 ENOG4105EW9 transcriptional regulator AsnC family ACX60_17625 ENOG4105D3G Pseudouridine synthase ACX60_17695 ENOG4108I0Z Aconitate hydratase ACX60_17700 ENOG4105BZN citrate synthase ACX60_17705 ENOG4105CR4 methylisocitrate lyase ACX60_17710 ENOG4105DRR Transcriptional regulator, GntR family ACX60_17715 ENOG4105CGF Aromatic amino acid aminotransferase ACX60_17720 ENOG4105CXG d-lactate dehydrogenase ACX60_17730 ENOG41073TP transcriptional regulator ACX60_17735 ENOG4105DAA L-lactate ACX60_17740 ENOG4107QKV phosphomannomutase ACX60_17745 ENOG4105CMR udp-glucose 4-epimerase ACX60_17755 ENOG4105C6Y Udp-glucose 6-dehydrogenase ACX60_17760 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ACX60_17765 ENOG4105D3Q Sugar transferase ACX60_17770 ENOG4108RYC glycosyltransferase ACX60_17775 ENOG4105CG5 Glycosyl transferase (Group 1 ACX60_17790 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) ACX60_17805 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ACX60_17810 ENOG4105J5G Transferase hexapeptide repeat containing protein ACX60_17815 ENOG4107R5Z Oxidoreductase domain protein ACX60_17820 ENOG4107QQG Dehydrogenase ACX60_17825 ENOG4105DAY polysaccharide export protein ACX60_17835 ENOG4105D75 Capsular exopolysaccharide family ACX60_17840 ENOG4108V1T peptidylprolyl cis-trans isomerase ACX60_17845 ENOG4108V1T peptidylprolyl cis-trans isomerase ACX60_17850 ENOG4105CJR Integral membrane protein (MviN ACX60_17855 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase ACX60_17860 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ACX60_17870 ENOG4105HSS phospholipase C ACX60_17895 ENOG41062JF Transcriptional regulator ACX60_17910 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ACX60_17915 ENOG4105UBK short-chain dehydrogenase reductase ACX60_17930 ENOG4107QZM n-acetylglutamate synthase ACX60_17935 ENOG4105GVF (ABC) transporter ACX60_17940 ENOG4105GVF (ABC) transporter ACX60_17945 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) ACX60_17950 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ACX60_17955 ENOG4108VM9 ABC, transporter ACX60_17960 ENOG4108R86 Transcriptional regulator ACX60_17965 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ACX60_17975 ENOG4105DTN riboflavin biosynthesis protein ribF ACX60_17980 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ACX60_17990 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase ACX60_18030 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ACX60_18085 ENOG4105CVE Lytic murein transglycosylase ACX60_18090 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ACX60_18095 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ACX60_18105 ENOG4105DFU Cell wall formation (By similarity) ACX60_18115 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase ACX60_18120 ENOG4105DU1 integral membrane protein, terc ACX60_18130 ENOG4106032 Glutathionylspermidine synthase ACX60_18140 ENOG4107QUY Guanine deaminase ACX60_18150 ENOG4108UGV hypoxanthine phosphoribosyltransferase ACX60_18160 ENOG4105T95 Thiol disulfide interChange protein ACX60_18165 ENOG4105PGM cation diffusion facilitator family transporter ACX60_18180 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ACX60_18195 ENOG4105VG0 50S ribosomal protein l34 ACX60_18265 ENOG4105DR5 peptidase ACX60_18290 ENOG4105KT5 UmuD protein ACX60_18295 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ACX60_18305 ENOG4105FA0 parb-like partition protein ACX60_18310 ENOG4107SKI cobyrinic Acid a,c-diamide synthase ACX60_18360 ENOG4107QHF type ii secretion system protein e ACX60_18495 ENOG4105KK6 nuclease ACX60_18600 ENOG4105CE1 Ferrous iron transport protein b ACX60_18605 ENOG4108A65 Transcriptional regulator ACX60_18620 ENOG4105MP0 transposase ACX60_18695 ENOG4105D6J arsenicaL-resistance protein ACX60_18730 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ACX60_18780 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ACX60_18810 ENOG4105CHH sulfate transporter ACX60_18870 ENOG4108K0D peptidase, M48