locus-tag class description HKO16_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HKO16_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKO16_00030 ENOG4105DQR SNARE associated Golgi HKO16_00035 ENOG4105C5H ABC transporter HKO16_00040 ENOG4108821 RND type efflux pump HKO16_00045 ENOG4108821 RND type efflux pump HKO16_00050 ENOG4108821 RND type efflux pump HKO16_00060 ENOG4105D74 hydrolase HKO16_00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HKO16_00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HKO16_00110 ENOG4105C8J )-transporter HKO16_00120 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HKO16_00150 ENOG4105C2W permease HKO16_00160 ENOG4108IG5 Transcriptional regulator HKO16_00165 ENOG4105DJY efflux transporter, rnd family, mfp subunit HKO16_00200 ENOG4105F27 Major Facilitator HKO16_00205 ENOG4105CV8 reductase HKO16_00210 ENOG4105HEI LysR family (Transcriptional regulator HKO16_00230 ENOG4105DQ4 alcohol dehydrogenase HKO16_00235 ENOG4108R3E Dna-3-methyladenine glycosylase i HKO16_00250 ENOG4105CEN a g-specific adenine glycosylase HKO16_00270 ENOG4108ZZ3 UPF0260 protein HKO16_00280 ENOG4105D1H recombination factor protein RarA HKO16_00285 ENOG4105S64 Formate nitrite transporter HKO16_00305 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKO16_00310 ENOG4108RWI nicotinamidase HKO16_00315 ENOG4105C09 Bile acid HKO16_00320 ENOG4107QI1 Mate efflux family protein HKO16_00325 ENOG4105EWC Purine nucleoside phosphorylase HKO16_00345 ENOG4108RXX maleylacetoacetate isomerase HKO16_00355 ENOG4105C85 amino acid HKO16_00365 ENOG4105CKI cobalamin synthesis protein HKO16_00375 ENOG4105CZE histidine utilization repressor HKO16_00395 ENOG4105C85 amino acid HKO16_00405 ENOG41088SP formiminoglutamate hydrolase HKO16_00425 ENOG4108NIW Leucine export protein LeuE HKO16_00440 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HKO16_00450 ENOG4108ZAI phosphatidylglycerophosphatase a HKO16_00455 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HKO16_00470 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HKO16_00515 ENOG4105KHC sulfurtransferase HKO16_00530 ENOG4105BZU Histidine kinase HKO16_00535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKO16_00550 ENOG4107QJQ Mate efflux family protein HKO16_00555 ENOG4105CHM Aminotransferase HKO16_00560 ENOG4106BRA Membrane HKO16_00575 ENOG4105D9M gamma-glutamylcysteine synthetase HKO16_00610 ENOG4108A65 Transcriptional regulator HKO16_00615 ENOG4105CE1 Ferrous iron transport protein b HKO16_00710 ENOG4105KK6 nuclease HKO16_00830 ENOG4107QHF type ii secretion system protein e HKO16_00880 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HKO16_00885 ENOG4105FA0 parb-like partition protein HKO16_00895 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HKO16_00900 ENOG4105KT5 UmuD protein HKO16_00925 ENOG4105DR5 peptidase HKO16_01095 ENOG4108K0D peptidase, M48 HKO16_01160 ENOG4105CHH sulfate transporter HKO16_01170 ENOG4105C0P Mg chelatase subunit ChlI HKO16_01185 ENOG4105BZU Histidine kinase HKO16_01195 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HKO16_01235 ENOG4108K5H permease YjgP YjgQ family protein HKO16_01240 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HKO16_01245 ENOG4105CN1 protease HKO16_01250 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HKO16_01255 ENOG4107TUY Histidine kinase HKO16_01265 ENOG41061WM D-Alanyl-D-Alanine HKO16_01275 ENOG4105D6E homoserine dehydrogenase HKO16_01280 ENOG4105T95 Thiol disulfide interChange protein HKO16_01285 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HKO16_01295 ENOG4105CE1 Ferrous iron transport protein b HKO16_01310 ENOG4105CNI cell division protein FtsW HKO16_01315 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HKO16_01325 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HKO16_01350 ENOG4108RNG Permease of the drug metabolite transporter HKO16_01355 ENOG4105DFG type I secretion outer membrane protein HKO16_01360 ENOG4108UTW Plays a role in the regulation of phosphate uptake HKO16_01375 ENOG4108HRK Histidine kinase HKO16_01380 ENOG4108NEV two component transcriptional regulator, LytTR family HKO16_01385 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HKO16_01415 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HKO16_01430 ENOG4105GVR general secretion pathway protein D HKO16_01435 ENOG4105TV9 FHA Domain-Containing protein HKO16_01440 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HKO16_01480 ENOG4105PM1 preprotein translocase subunit SecE HKO16_01485 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HKO16_01535 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HKO16_01540 ENOG4105D3Y Na H antiporter HKO16_01555 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HKO16_01570 ENOG4107ZXU DSBA oxidoreductase HKO16_01635 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HKO16_01640 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HKO16_01670 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HKO16_01680 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HKO16_01695 ENOG4105C2N RNA methyltransferase TrmH family group 3 HKO16_01705 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HKO16_01720 ENOG4107QHF type ii secretion system protein e HKO16_01730 ENOG4107EJC Preprotein translocase subunit SecG HKO16_01750 ENOG4105CHV Transcription elongation factor NusA HKO16_01765 ENOG4105KJM monovalent cation h antiporter subunit g HKO16_01770 ENOG4105W4C monovalent cation H antiporter subunit F HKO16_01775 ENOG4105SC1 monovalent cation H antiporter subunit E HKO16_01780 ENOG4107R4Z monovalent cation h antiporter subunit d HKO16_01785 ENOG4108ZE9 Monovalent cation H antiporter subunit C HKO16_01790 ENOG4105D65 subunit l HKO16_01805 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HKO16_01825 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HKO16_01835 ENOG4105CSR polyphosphate kinase 2 HKO16_01845 ENOG4105DSY exodeoxyribonuclease V, gamma HKO16_01850 ENOG4107QKA exodeoxyribonuclease V beta HKO16_01855 ENOG4107QYX exodeoxyribonuclease v alpha HKO16_01875 ENOG4107QUT magnesium and cobalt transport protein CorA HKO16_01880 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) HKO16_01885 ENOG4105DVC DnaJ domain protein HKO16_01900 ENOG4105CKD glutathione-regulated potassium-efflux system protein HKO16_01905 ENOG4105C25 Primosomal protein n' HKO16_01910 ENOG4105D7Q type ii secretion system HKO16_01915 ENOG4108VAU general secretion pathway protein G HKO16_01925 ENOG4108Z7R Chaperone CsaA HKO16_01930 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HKO16_01935 ENOG4108JU5 Magnesium and cobalt efflux protein HKO16_01940 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HKO16_01950 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HKO16_01960 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HKO16_01975 ENOG4105C5X domain protein HKO16_01980 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HKO16_01990 ENOG4105BZ8 glutamate synthase HKO16_02020 ENOG4107T8P acyl-Coa dehydrogenase HKO16_02030 ENOG4107QI1 Mate efflux family protein HKO16_02040 ENOG4105CSA Coproporphyrinogen iii oxidase HKO16_02050 ENOG4105CBN LysR family transcriptional regulator HKO16_02065 ENOG4105J5T Amp-dependent synthetase and ligase HKO16_02070 ENOG4105C03 ribonuclease HKO16_02080 ENOG4105EI2 Pseudouridine synthase HKO16_02085 ENOG4107XGZ Hydrolase HKO16_02090 ENOG4105D29 Helix-turn-helix type 11 domain protein HKO16_02105 ENOG4108W5M transcriptional regulator HKO16_02120 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HKO16_02135 ENOG4105DUM transcriptional regulator, lysR family HKO16_02160 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HKO16_02215 ENOG4105CK2 sodium dicarboxylate symporter HKO16_02225 ENOG4105D1S lipid A biosynthesis HKO16_02230 ENOG4105N14 lysine exporter protein LysE YggA HKO16_02235 ENOG4105C5H ABC transporter HKO16_02250 ENOG4105KVH Transcriptional regulator HKO16_02260 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HKO16_02275 ENOG4105C4R Atp-dependent dna helicase HKO16_02280 ENOG4105VFU Rna-binding protein HKO16_02300 ENOG4105CKD glutathione-regulated potassium-efflux system protein HKO16_02315 ENOG4107RGH Aldehyde dehydrogenase HKO16_02325 ENOG4105CIY formyltetrahydrofolate deformylase HKO16_02425 ENOG4105DWV Homoserine O-trans-acetylase HKO16_02445 ENOG4108ESX Receptor HKO16_02455 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HKO16_02475 ENOG4107GFK fumarate HKO16_02480 ENOG4108DNC Involved in acetate metabolism (By similarity) HKO16_02485 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HKO16_02490 ENOG4105C01 Dihydroxy-acid dehydratase HKO16_02495 ENOG4108UHU Aldolase HKO16_02500 ENOG4105C6Z Gluconate HKO16_02505 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HKO16_02510 ENOG4105C26 Dehydrogenase HKO16_02520 ENOG4106HB6 Alpha beta hydrolase HKO16_02535 ENOG4105CN1 protease HKO16_02550 ENOG4105WVQ Fe-S assembly protein IscX HKO16_02570 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HKO16_02590 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HKO16_02610 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HKO16_02625 ENOG4105CEY Amp-dependent synthetase and ligase HKO16_02630 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HKO16_02640 ENOG4105C84 Histidine ammonia-lyase HKO16_02670 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HKO16_02680 ENOG4105C2D reductase HKO16_02685 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HKO16_02705 ENOG4105VW4 glutaredoxin 3 HKO16_02715 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HKO16_02720 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HKO16_02730 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HKO16_02735 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKO16_02740 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HKO16_02745 ENOG4105DJY efflux transporter, rnd family, mfp subunit HKO16_02770 ENOG4105C7K acetolactate synthase HKO16_02775 ENOG4108ZP8 Acetolactate synthase small subunit HKO16_02785 ENOG4105BZU Histidine kinase HKO16_02825 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HKO16_02840 ENOG4105F8V Hydrolase, tatD family HKO16_02845 ENOG4107QM5 aconitate hydratase HKO16_02850 ENOG4105CUZ uba thif-type nad fad binding protein HKO16_02860 ENOG4107RSM transcriptional regulator HKO16_02870 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HKO16_02885 ENOG4106UX7 integral membrane protein HKO16_02890 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HKO16_02895 ENOG4105W8H transhydrogenase (subunit alpha HKO16_02900 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HKO16_02915 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HKO16_02920 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HKO16_02925 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HKO16_02930 ENOG4105BZU Histidine kinase HKO16_02935 ENOG4105C6T cysteine synthase HKO16_02950 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HKO16_02960 ENOG4105DXN mazG family HKO16_02965 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HKO16_02970 ENOG4105DJ0 Poly(A) Polymerase HKO16_02975 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HKO16_02995 ENOG41080Z8 PHOSPHOCARRIER protein HKO16_03000 ENOG4105N42 UPF0307 protein HKO16_03005 ENOG4105CEY Amp-dependent synthetase and ligase HKO16_03020 ENOG4105CYM Glutathione S-transferase HKO16_03025 ENOG4105W39 Membrane HKO16_03065 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HKO16_03085 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HKO16_03095 ENOG4105C9X ppx gppa phosphatase HKO16_03105 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HKO16_03110 ENOG4105II7 pyrroline-5-carboxylate reductase HKO16_03115 ENOG4108VIA integral membrane protein HKO16_03120 ENOG4105C2M dna polymerase I HKO16_03140 ENOG4107QHF type ii secretion system protein e HKO16_03145 ENOG4108ZHJ Organic hydroperoxide resistance protein HKO16_03150 ENOG4105K56 Transcriptional regulator HKO16_03220 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HKO16_03225 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HKO16_03230 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HKO16_03240 ENOG4105CRQ synthase (Component I) HKO16_03285 ENOG4108Z0R Transferase HKO16_03290 ENOG41072GX Peptidase M22 Glycoprotease HKO16_03315 ENOG4105DJV ribulose-phosphate 3-epimerase HKO16_03320 ENOG4108HCJ Hydrolase HKO16_03330 ENOG4105E3B Multicopper oxidase HKO16_03350 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HKO16_03355 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HKO16_03360 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HKO16_03395 ENOG4105ETT transcriptional Regulator, LysR family HKO16_03400 ENOG4105C1G acyl-Coa dehydrogenase HKO16_03405 ENOG4107RGD Major Facilitator superfamily HKO16_03410 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HKO16_03420 ENOG4107EFR Flavocytochrome c HKO16_03425 ENOG4106P55 Transcriptional regulator HKO16_03440 ENOG4106P55 Transcriptional regulator HKO16_03450 ENOG4105CH2 amidohydrolase HKO16_03470 ENOG4105ETT transcriptional Regulator, LysR family HKO16_03485 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HKO16_03530 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKO16_03540 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HKO16_03545 ENOG4107EXC regulatoR HKO16_03550 ENOG4105E0F Histidine kinase HKO16_03560 ENOG4105BZU Histidine kinase HKO16_03580 ENOG4105GKE subunit e HKO16_03585 ENOG4107QIZ NADH dehydrogenase HKO16_03590 ENOG4108IEH NADH dehydrogenase subunit g HKO16_03605 ENOG4107UFS subunit j HKO16_03615 ENOG4105D65 subunit l HKO16_03620 ENOG4105C8S subunit m HKO16_03645 ENOG4105DUM transcriptional regulator, lysR family HKO16_03650 ENOG4105DP0 ferredoxin-NADP reductase HKO16_03675 ENOG4105CBX hi0933 family HKO16_03680 ENOG4105K6H D-cysteine desulfhydrase HKO16_03710 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HKO16_03720 ENOG4105D1F ATP-binding protein HKO16_03770 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HKO16_03780 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HKO16_03795 ENOG4105HF0 Membrane HKO16_03805 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HKO16_03825 ENOG4106UW1 Major Facilitator superfamily HKO16_03830 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HKO16_03835 ENOG4108K4C ec 3.1.3.12 HKO16_03840 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HKO16_03850 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HKO16_03855 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HKO16_03865 ENOG4105FE9 pseudouridine synthase HKO16_03870 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HKO16_03875 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HKO16_03880 ENOG4107RTD sua5 ycio yrdc ywlc family protein HKO16_03885 ENOG4108BPE -transporting atpase HKO16_03890 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HKO16_03900 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HKO16_03905 ENOG4105CHR reductase HKO16_03915 ENOG4109066 lysm domain bon superfamily protein HKO16_03920 ENOG4105DWF phosphomethylpyrimidine kinase HKO16_03930 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HKO16_03960 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HKO16_03990 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HKO16_04005 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HKO16_04010 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HKO16_04015 ENOG4105C34 Pseudouridine synthase HKO16_04020 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HKO16_04040 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HKO16_04060 ENOG4105EJC lysr family transcriptional regulator HKO16_04065 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HKO16_04070 ENOG4105C94 Transporter HKO16_04080 ENOG4105DVW rieske (2Fe-2S) HKO16_04085 ENOG4105C26 Dehydrogenase HKO16_04090 ENOG4105E3J oxidoreductase HKO16_04105 ENOG4105C4K Nad synthetase HKO16_04115 ENOG4105EUB pirin domain protein HKO16_04120 ENOG4108YXA Membrane HKO16_04165 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HKO16_04175 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HKO16_04180 ENOG4105C3M thioredoxin reductase HKO16_04185 ENOG4105CNU cell division protein FtsK HKO16_04190 ENOG4105CCF Lysine exporter protein (Lyse ygga) HKO16_04205 ENOG4107QMS site-determining protein HKO16_04220 ENOG4106HNH Acyl-transferase HKO16_04225 ENOG4108ZG0 Ompa motb domain protein HKO16_04230 ENOG4105C4R Atp-dependent dna helicase HKO16_04240 ENOG4107QKV phosphomannomutase HKO16_04255 ENOG4105E7A Glutamine amidotransferase HKO16_04270 ENOG4105VDB UPF0125 protein HKO16_04280 ENOG41090R7 Ferric uptake HKO16_04285 ENOG4105CZX twitching motility protein HKO16_04290 ENOG4105CZX twitching motility protein HKO16_04295 ENOG4105DFA alanine racemase domain protein HKO16_04300 ENOG4105EYH Exonuclease HKO16_04305 ENOG4107RH8 nuclease SbcCD subunit D HKO16_04325 ENOG4105ECP epimerase HKO16_04330 ENOG4105MWK D-amino acid dehydrogenase, small subunit HKO16_04335 ENOG4105D52 delta-aminolevulinic acid dehydratase HKO16_04340 ENOG4108VUY thioesterase Superfamily protein HKO16_04345 ENOG4105CW7 secretion protein, HlyD family HKO16_04350 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKO16_04355 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HKO16_04395 ENOG4105C54 Major Facilitator superfamily HKO16_04400 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKO16_04425 ENOG4105D5Q Arginine ornithine antiporter HKO16_04430 ENOG4107QK5 Homocysteine s-methyltransferase HKO16_04455 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HKO16_04460 ENOG4105C94 Transporter HKO16_04465 ENOG4105C94 Transporter HKO16_04475 ENOG4108S4H thioesterase Superfamily protein HKO16_04485 ENOG4105CKI cobalamin synthesis protein HKO16_04495 ENOG4108VWS Yaeq family HKO16_04505 ENOG4107BJW polysaccharide deacetylase HKO16_04510 ENOG4105CND Glycosyl transferase, family 2 HKO16_04520 ENOG4106YT9 Enoyl-CoA hydratase HKO16_04535 ENOG41069M3 Transcriptional regulator HKO16_04555 ENOG4105CHR reductase HKO16_04565 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HKO16_04570 ENOG4105DJB Major Facilitator Superfamily HKO16_04580 ENOG4108MXF Alpha Beta Hydrolase HKO16_04585 ENOG4105CHR reductase HKO16_04600 ENOG4105C7K acetolactate synthase HKO16_04610 ENOG4105CSH Transporter HKO16_04615 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HKO16_04620 ENOG4105CSV Glutaminase HKO16_04625 ENOG4108R6W Transcriptional regulator, ARAC family HKO16_04630 ENOG4105EU0 Major facilitator Superfamily HKO16_04640 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HKO16_04650 ENOG4108PZW LysR family Transcriptional regulator HKO16_04660 ENOG4105CSP Major Facilitator Superfamily HKO16_04675 ENOG4105C3R Methionine synthase HKO16_04680 ENOG4105CJ3 phosphate transporter HKO16_04700 ENOG4105E6M Sulphatase-modifying factor protein HKO16_04705 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HKO16_04720 ENOG4107RNH Outer membrane receptor FepA HKO16_04740 ENOG4108UJV acyl-CoA thioesterase i HKO16_04745 ENOG4108I0Y (ABC) transporter HKO16_04750 ENOG4105CV6 ABC transporter, permease HKO16_04755 ENOG4107U91 Rhomboid family HKO16_04780 ENOG4105C5Q Transcriptional regulator HKO16_04790 ENOG4107QZF nitrite reductase NADPH large subunit HKO16_04795 ENOG4105VCQ rubredoxin HKO16_04815 ENOG4108MRJ HKO16_04830 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HKO16_04845 ENOG4105D4T Citrate transporter HKO16_04850 ENOG4105C37 (CBS) domain HKO16_04860 ENOG4107RET Isocitrate lyase HKO16_04895 ENOG4105CQM Urea amidohydrolase subunit alpha HKO16_04905 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HKO16_04920 ENOG4106H78 methyltransferase HKO16_04925 ENOG4105CJN penicillin-binding protein HKO16_04950 ENOG4105CSM endonuclease III HKO16_04955 ENOG4108R3D Electron transport complex HKO16_04960 ENOG4105D82 Glutamate dehydrogenase HKO16_04970 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HKO16_04995 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HKO16_05035 ENOG4107RAQ aminopeptidase HKO16_05040 ENOG4105D0A hydroxylase HKO16_05045 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HKO16_05065 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HKO16_05070 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HKO16_05080 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HKO16_05090 ENOG4105W4M Transport-associated protein HKO16_05100 ENOG4105E09 nadh pyrophosphatase HKO16_05110 ENOG4107RZZ dna polymerase iii epsilon subunit HKO16_05115 ENOG4105E9H Lytic Murein transglycosylase HKO16_05115 ENOG4105E9H Lytic Murein transglycosylase HKO16_05125 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HKO16_05130 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HKO16_05135 ENOG4108JQ5 ABC transporter HKO16_05155 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HKO16_05180 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKO16_05215 ENOG4105M4H endoribonuclease L-psp HKO16_05220 ENOG4105MWK D-amino acid dehydrogenase, small subunit HKO16_05225 ENOG4105CR8 Transcriptional regulator HKO16_05245 ENOG4105D01 (LipO)protein HKO16_05270 ENOG4105C85 amino acid HKO16_05280 ENOG4105CUB amino acid HKO16_05300 ENOG4105C26 Dehydrogenase HKO16_05320 ENOG4105C85 amino acid HKO16_05340 ENOG4107RGH Aldehyde dehydrogenase HKO16_05345 ENOG4108ZX5 transcriptional regulator HKO16_05350 ENOG4105DJP Membrane HKO16_05355 ENOG4105CTX dehydratase HKO16_05360 ENOG4105DJB Major Facilitator Superfamily HKO16_05365 ENOG4105EQX glucarate dehydratase HKO16_05375 ENOG4105CZJ Aldehyde dehydrogenase HKO16_05380 ENOG4105JXH GntR family transcriptional regulator HKO16_05395 ENOG4105NI3 Protein of unknown function (DUF3237) HKO16_05400 ENOG4105EPF Outer membrane porin HKO16_05405 ENOG4105C1G acyl-Coa dehydrogenase HKO16_05420 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HKO16_05425 ENOG4108SC4 )-transporter HKO16_05440 ENOG4105E3J oxidoreductase HKO16_05450 ENOG4105D2S major facilitator superfamily HKO16_05455 ENOG4105EPF Outer membrane porin HKO16_05475 ENOG4107RN6 Monooxygenase HKO16_05485 ENOG4105JQZ Methyltransferase HKO16_05490 ENOG4105F95 Monooxygenase HKO16_05525 ENOG4105F95 Monooxygenase HKO16_05535 ENOG4105C7N Xanthine uracil vitamin C permease HKO16_05540 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HKO16_05545 ENOG4105CPW cytochrome b561 HKO16_05555 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HKO16_05565 ENOG4105CFH Aspartokinase HKO16_05615 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HKO16_05620 ENOG4105W7J DNA binding HKO16_05705 ENOG4107ZQ5 Phage-associated protein, HI1409 family HKO16_05725 ENOG41090AG Bacteriophage protein HKO16_05860 ENOG4105DFP Integrase HKO16_05870 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HKO16_05880 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HKO16_05895 ENOG4105CPC Aldo Keto reductase HKO16_05900 ENOG4107RYR Transcriptional regulator, Crp Fnr family HKO16_05905 ENOG4108UKZ OsmC family HKO16_05920 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKO16_05950 ENOG4105CD3 dihydroorotase HKO16_05955 ENOG4108ZG0 Ompa motb domain protein HKO16_05965 ENOG4108TGY Glutathione S-transferase HKO16_05970 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HKO16_05980 ENOG4108K3A Glutathione S-transferase HKO16_05990 ENOG4108JU3 Alkyl hydroperoxide reductase HKO16_06000 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HKO16_06010 ENOG4105D3R alkyl hydroperoxide reductase HKO16_06015 ENOG4105CQ7 ATP-dependent helicase HKO16_06030 ENOG4105D2S major facilitator superfamily HKO16_06035 ENOG4105DKK Benzoate HKO16_06040 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase HKO16_06045 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HKO16_06050 ENOG4108UKV benzoate 1,2-dioxygenase HKO16_06055 ENOG4105FUY alpha subunit HKO16_06060 ENOG4108KB2 LysR family Transcriptional regulator HKO16_06110 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HKO16_06145 ENOG410829K Lysine exporter protein (Lyse ygga) HKO16_06150 ENOG4105VEQ Cold shock protein HKO16_06160 ENOG4105II7 pyrroline-5-carboxylate reductase HKO16_06225 ENOG4105C2X Arabinose 5-phosphate isomerase HKO16_06240 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HKO16_06245 ENOG4108IUZ ABC transporter HKO16_06255 ENOG4105DFG type I secretion outer membrane protein HKO16_06295 ENOG4108Z4U Ferredoxin HKO16_06320 ENOG4105BZU Histidine kinase HKO16_06325 ENOG4105D1S lipid A biosynthesis HKO16_06330 ENOG4105D7N magnesium and cobalt transport protein CorA HKO16_06345 ENOG4105D2S major facilitator superfamily HKO16_06365 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HKO16_06400 ENOG4108WAV Transcriptional regulator HKO16_06405 ENOG4105C5A transporter HKO16_06425 ENOG4108JIK carboxylase HKO16_06430 ENOG4107R4J Chloride channel HKO16_06440 ENOG4105R8C Transcriptional regulator HKO16_06450 ENOG4105E2A Dehydrogenase HKO16_06465 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HKO16_06470 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HKO16_06490 ENOG4105MRR Transcriptional regulator (By similarity) HKO16_06500 ENOG4108HW3 (ABC) transporter HKO16_06530 ENOG4105E6M Sulphatase-modifying factor protein HKO16_06595 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKO16_06625 ENOG4105EMY transcriptional regulator HKO16_06635 ENOG4107Y2X deaminase HKO16_06640 ENOG4105DJ2 Major Facilitator Superfamily HKO16_06655 ENOG4105WPN DNA integration recombination invertion protein HKO16_06665 ENOG4108Z4X TRANSCRIPTIONal HKO16_06675 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKO16_06695 ENOG4105MWK D-amino acid dehydrogenase, small subunit HKO16_06720 ENOG4105CZJ Aldehyde dehydrogenase HKO16_06725 ENOG4107QTZ amino acid HKO16_06730 ENOG4105EJQ L-serine dehydratase HKO16_06735 ENOG4105DXM phenylacetic acid degradation protein HKO16_06740 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HKO16_06745 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HKO16_06750 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HKO16_06755 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HKO16_06760 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HKO16_06765 ENOG4105E39 Enoyl-CoA hydratase HKO16_06770 ENOG4108UKI Enoyl-CoA hydratase HKO16_06775 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HKO16_06780 ENOG4105CHU acetyl-coa acetyltransferase HKO16_06785 ENOG4105DZS Phenylacetate-CoA ligase HKO16_06790 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HKO16_06795 ENOG4108Z0R Transferase HKO16_06800 ENOG4107YAU phenylacetic acid degradation protein HKO16_06830 ENOG4107VGR Catalase HKO16_06835 ENOG4105CPW cytochrome b561 HKO16_06840 ENOG4105HEI LysR family (Transcriptional regulator HKO16_06850 ENOG4107HP6 Transcriptional regulator HKO16_06855 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HKO16_06870 ENOG4105C4Y ABC transporter HKO16_06875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HKO16_06880 ENOG4107RCV ABC transporter, permease HKO16_06890 ENOG4107STF Involved in phosphonate degradation (By similarity) HKO16_06895 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HKO16_06915 ENOG4105CC0 LysR family Transcriptional regulator HKO16_06930 ENOG4105E39 Enoyl-CoA hydratase HKO16_06935 ENOG4107QX3 carboxylase HKO16_06940 ENOG4105C1G acyl-Coa dehydrogenase HKO16_06945 ENOG4105R8C Transcriptional regulator HKO16_06950 ENOG4105CEY Amp-dependent synthetase and ligase HKO16_06970 ENOG4105HEI LysR family (Transcriptional regulator HKO16_07020 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HKO16_07050 ENOG4105EW9 transcriptional regulator AsnC family HKO16_07060 ENOG4105BZU Histidine kinase HKO16_07065 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HKO16_07080 ENOG4105EAD ABC transporter HKO16_07085 ENOG4108HW4 amino acid AbC transporter HKO16_07095 ENOG4107RP9 extracellular solute-binding protein, family 3 HKO16_07100 ENOG4105CT1 (ABC) transporter HKO16_07110 ENOG4105EXG Transcriptional regulator HKO16_07125 ENOG4105C9B Cysteine desulfurase HKO16_07130 ENOG4105ESN nucleotide-binding protein HKO16_07135 ENOG4105D7W serine acetyltransferase HKO16_07145 ENOG4105CHR reductase HKO16_07150 ENOG4105CBN LysR family transcriptional regulator HKO16_07155 ENOG4105CYM Glutathione S-transferase HKO16_07160 ENOG4108SHQ Glutathione S-transferase HKO16_07165 ENOG4105CMU LysR family (Transcriptional regulator HKO16_07170 ENOG4105VAW lrga family HKO16_07175 ENOG41067MG lrgb family HKO16_07180 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKO16_07195 ENOG4105DXI Major Facilitator superfamily HKO16_07205 ENOG4105ETT transcriptional Regulator, LysR family HKO16_07215 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HKO16_07220 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) HKO16_07235 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase HKO16_07240 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HKO16_07255 ENOG4108K70 Transcriptional regulator HKO16_07260 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKO16_07270 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HKO16_07275 ENOG4105C4M (Ubiquinol oxidase) subunit I HKO16_07295 ENOG4105C54 Major Facilitator superfamily HKO16_07305 ENOG4106FTQ Taurine ABC transporter, periplasmic HKO16_07310 ENOG4108IY8 ABC, transporter HKO16_07315 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HKO16_07330 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HKO16_07340 ENOG4105CBN LysR family transcriptional regulator HKO16_07350 ENOG4105CPN adenine deaminase HKO16_07365 ENOG41082YX Transcriptional regulator, arsr family HKO16_07370 ENOG4105D6J arsenicaL-resistance protein HKO16_07375 ENOG4108KB2 LysR family Transcriptional regulator HKO16_07390 ENOG4108JU3 Alkyl hydroperoxide reductase HKO16_07415 ENOG4105C0B DNA polymerase III (alpha subunit) HKO16_07425 ENOG4105CK2 sodium dicarboxylate symporter HKO16_07430 ENOG4105CHM Aminotransferase HKO16_07440 ENOG4108V06 Glutathione peroxidase HKO16_07445 ENOG4105E7U AraC family transcriptional regulator HKO16_07475 ENOG4105ZED uncharacterized protein ygaH HKO16_07480 ENOG4108UMN azlc family HKO16_07505 ENOG4105C3G gtp-binding protein HKO16_07510 ENOG4108UMI ABC transporter, permease HKO16_07515 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HKO16_07520 ENOG4105D01 (LipO)protein HKO16_07525 ENOG4105D01 (LipO)protein HKO16_07540 ENOG4107T8P acyl-Coa dehydrogenase HKO16_07555 ENOG4105EAD ABC transporter HKO16_07560 ENOG4105DRP amino acid AbC transporter HKO16_07565 ENOG4105CDA abc transporter atp-binding protein HKO16_07575 ENOG4105EW9 transcriptional regulator AsnC family HKO16_07590 ENOG41067SE Tetr family transcriptional regulator HKO16_07610 ENOG4105CC0 LysR family Transcriptional regulator HKO16_07620 ENOG4105ETS cytosine purines uracil thiamine allantoin HKO16_07630 ENOG4108IPJ Membrane HKO16_07655 ENOG4105GQR Chaperone HKO16_07660 ENOG4105X0I Fimbrial HKO16_07680 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HKO16_07685 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HKO16_07705 ENOG4108HWY Beta-lactamase HKO16_07730 ENOG4105CV1 Transketolase (EC 2.2.1.1) HKO16_07740 ENOG4108YYC ycei family HKO16_07750 ENOG4108T58 Mg2 transport protein CorA HKO16_07765 ENOG4105YGK Pfam:UPF0157 HKO16_07770 ENOG4105C26 Dehydrogenase HKO16_07775 ENOG4105EW9 transcriptional regulator AsnC family HKO16_07780 ENOG4105CK7 Sodium proline symporter HKO16_07785 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HKO16_07795 ENOG4108ZX5 transcriptional regulator HKO16_07805 ENOG4105BZ1 (ABC) transporter HKO16_07810 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HKO16_07815 ENOG4105XPP Protein of unknown function (DUF1275) HKO16_07825 ENOG41080HT Transcriptional regulator, arsr family HKO16_07835 ENOG4105EZE Cupin 4 family protein HKO16_07840 ENOG4108UHJ MAF-like protein HKO16_07860 ENOG4105D2N Aldolase HKO16_07865 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HKO16_07870 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HKO16_07875 ENOG4105EHM Aminoglycoside phosphotransferase HKO16_07880 ENOG4108S0S Nucleotidyl transferase HKO16_07890 ENOG4107QJE Chromosome Partitioning Protein HKO16_07895 ENOG4105FA0 parb-like partition protein HKO16_07910 ENOG4105BZ1 (ABC) transporter HKO16_07915 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HKO16_07925 ENOG4107QRG dna polymerase iii HKO16_07935 ENOG4105F8V Hydrolase, tatD family HKO16_07960 ENOG4108RTD type II secretion system protein K HKO16_07980 ENOG4108Z6B deaminase HKO16_07995 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HKO16_08000 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HKO16_08020 ENOG4107RN6 Monooxygenase HKO16_08030 ENOG4105D6Z AFG1 family ATPase HKO16_08100 ENOG4105CDU Replicative dna helicase HKO16_08190 ENOG4105EFC phage portal protein HK97 family HKO16_08300 ENOG4107QP3 malate synthase g HKO16_08310 ENOG4105SG9 biopolymer transport protein, ExbD HKO16_08350 ENOG4105DGW oligopeptidase A HKO16_08360 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HKO16_08380 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HKO16_08395 ENOG4105K4T epimerase HKO16_08400 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HKO16_08420 ENOG4108JA2 transcriptioN-repair coupling factor HKO16_08430 ENOG4105F8J Adenylate Guanylate cyclase HKO16_08435 ENOG4108ZIT Ferredoxin, 2FE-2S HKO16_08450 ENOG4108Z4V iron-sulfur cluster assembly HKO16_08455 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HKO16_08465 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HKO16_08480 ENOG4105K70 DNA-binding protein HKO16_08490 ENOG4105E7U AraC family transcriptional regulator HKO16_08495 ENOG4105EEF Alkane 1-monooxygenase HKO16_08500 ENOG4105C1G acyl-Coa dehydrogenase HKO16_08505 ENOG4105C1G acyl-Coa dehydrogenase HKO16_08520 ENOG4108Z66 YbaK ebsC protein HKO16_08535 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKO16_08540 ENOG4105DUU IucA IucC family protein HKO16_08545 ENOG4105DJU Siderophore biosynthesis protein HKO16_08555 ENOG4105JSC dimethylmenaquinone methyltransferase HKO16_08595 ENOG4108YZT Adenosylcobinamide kinase HKO16_08600 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HKO16_08605 ENOG4107TB6 phosphoglycerate mutase HKO16_08620 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HKO16_08625 ENOG4107TSN permease HKO16_08645 ENOG4105CNM Receptor HKO16_08650 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HKO16_08665 ENOG4105CJ1 ABC, transporter HKO16_08670 ENOG4107QWP ABC-2 type transporter HKO16_08675 ENOG4107QWP ABC-2 type transporter HKO16_08700 ENOG4105K59 histidine triad (HIT) protein HKO16_08730 ENOG4105F2W methyltransferase HKO16_08740 ENOG4105C28 cystathionine HKO16_08755 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HKO16_08760 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HKO16_08790 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HKO16_08800 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HKO16_08805 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HKO16_08815 ENOG4105BZU Histidine kinase HKO16_08830 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HKO16_08835 ENOG4107R0V Pyruvate dehydrogenase HKO16_08840 ENOG4105CPP Dehydrogenase, E1 component HKO16_08855 ENOG4105CHR reductase HKO16_08865 ENOG4105FFC UPF0187 protein HKO16_08875 ENOG4107S76 domain protein HKO16_08885 ENOG4108VCT Sulfite exporter TauE/SafE HKO16_08900 ENOG4105UEI Transcriptional Regulator AraC Family HKO16_08905 ENOG4105KVH Transcriptional regulator HKO16_08910 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HKO16_08935 ENOG4106FTQ Taurine ABC transporter, periplasmic HKO16_08940 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HKO16_08960 ENOG4105CSH Transporter HKO16_08970 ENOG4108IJ0 Aspartate ammonia-lyase HKO16_08985 ENOG4107YNJ LysR family Transcriptional regulator HKO16_08995 ENOG4105CHU acetyl-coa acetyltransferase HKO16_09000 ENOG4105CRW Short chain fatty acid transporter HKO16_09015 ENOG4108M0I Transcriptional regulator HKO16_09035 ENOG4108IND Tetr family transcriptional regulator HKO16_09045 ENOG4105CY2 Citrate transporter HKO16_09050 ENOG4105DTD Dehydrogenase HKO16_09055 ENOG4105CF7 AraC family transcriptional regulator HKO16_09060 ENOG4105D2S major facilitator superfamily HKO16_09070 ENOG4105CHR reductase HKO16_09115 ENOG4105BZS acriflavin resistance protein HKO16_09120 ENOG4105C1P efflux transporter, rnd family, mfp subunit HKO16_09125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKO16_09130 ENOG4105E0F Histidine kinase HKO16_09140 ENOG4108821 RND type efflux pump HKO16_09145 ENOG4108R6W Transcriptional regulator, ARAC family HKO16_09195 ENOG4105M03 Domain of unknown function (DUF955) HKO16_09230 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HKO16_09305 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HKO16_09325 ENOG4105E0A ABC, transporter HKO16_09330 ENOG4105EHG Permease protein HKO16_09340 ENOG4105DQ4 alcohol dehydrogenase HKO16_09345 ENOG4105CF7 AraC family transcriptional regulator HKO16_09350 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HKO16_09360 ENOG4105EXW epimerase dehydratase HKO16_09365 ENOG4105DDW LysR family Transcriptional regulator HKO16_09380 ENOG4105CZJ Aldehyde dehydrogenase HKO16_09395 ENOG4105CW7 secretion protein, HlyD family HKO16_09410 ENOG4106P55 Transcriptional regulator HKO16_09500 ENOG4105CEY Amp-dependent synthetase and ligase HKO16_09510 ENOG4105CSU acyl-Coa dehydrogenase HKO16_09520 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr HKO16_09525 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HKO16_09530 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HKO16_09535 ENOG4108PTX LysR family Transcriptional regulator HKO16_09540 ENOG4107Z3H Transcriptional regulator, TetR family HKO16_09565 ENOG4108Z6Z Transcriptional regulator HKO16_09575 ENOG4105NAE bifunctional deaminase-reductase domain protein HKO16_09585 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKO16_09600 ENOG4105CZJ Aldehyde dehydrogenase HKO16_09620 ENOG4107EJG GntR family transcriptional regulator HKO16_09630 ENOG4108KB2 LysR family Transcriptional regulator HKO16_09635 ENOG4105DTQ mandelate racemase muconate lactonizing HKO16_09640 ENOG4105NN7 muconolactone delta-isomerase HKO16_09650 ENOG4107QP7 CoA-transferase subunit A HKO16_09655 ENOG4107QNJ CoA-transferase subunit B HKO16_09660 ENOG4105CHU acetyl-coa acetyltransferase HKO16_09665 ENOG4105F2Z 3-oxoadipate enol-lactonase HKO16_09675 ENOG4105C26 Dehydrogenase HKO16_09685 ENOG4105F11 amine oxidase HKO16_09705 ENOG4105CHR reductase HKO16_09715 ENOG4105FUY alpha subunit HKO16_09735 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HKO16_09745 ENOG4105DNH Major Facilitator HKO16_09770 ENOG4105C1G acyl-Coa dehydrogenase HKO16_09775 ENOG4108PTX LysR family Transcriptional regulator HKO16_09780 ENOG4107HP6 Transcriptional regulator HKO16_09795 ENOG4105MD1 YeeE YedE family protein HKO16_09805 ENOG4105DZG Dehydrogenase HKO16_09810 ENOG4105TW1 Carbohydrate-selective porin OprB HKO16_09815 ENOG4106JPM 3-dehydroshikimate dehydratase HKO16_09820 ENOG4105FF2 Type I DHQase HKO16_09825 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HKO16_09830 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HKO16_09835 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HKO16_09840 ENOG4105D2S major facilitator superfamily HKO16_09845 ENOG4105F2Z 3-oxoadipate enol-lactonase HKO16_09850 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HKO16_09855 ENOG4105CHU acetyl-coa acetyltransferase HKO16_09860 ENOG4107QNJ CoA-transferase subunit B HKO16_09865 ENOG4107QP7 CoA-transferase subunit A HKO16_09875 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HKO16_09880 ENOG4107VMU Membrane HKO16_09925 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKO16_09940 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HKO16_09950 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HKO16_09955 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HKO16_09985 ENOG4105C7B Threonine dehydratase HKO16_09995 ENOG4105CZN Potassium uptake protein HKO16_10000 ENOG4105HDD phospholipase HKO16_10010 ENOG4105E0K tonB-dependent siderophore receptor HKO16_10025 ENOG4105PV3 Inner membrane protein yqiJ HKO16_10035 ENOG4105C4M (Ubiquinol oxidase) subunit I HKO16_10040 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HKO16_10060 ENOG41068P6 UPF0319 protein HKO16_10070 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HKO16_10095 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HKO16_10100 ENOG4105C8Y Acetylornithine aminotransferase HKO16_10105 ENOG4105M2J Glutaredoxin HKO16_10115 ENOG4105CC0 LysR family Transcriptional regulator HKO16_10120 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HKO16_10125 ENOG4105CWM branched-chain amino acid transport system II carrier protein HKO16_10150 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HKO16_10155 ENOG4105DE4 1-phosphofructokinase HKO16_10160 ENOG4105DM4 PTS System HKO16_10175 ENOG4105BZU Histidine kinase HKO16_10185 ENOG4105D8V Glucose sorbosone dehydrogenase HKO16_10190 ENOG4108RAV Conserved protein HKO16_10195 ENOG4105CHH sulfate transporter HKO16_10210 ENOG4105C85 amino acid HKO16_10220 ENOG4105F7P transcriptional regulator AsnC family HKO16_10245 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HKO16_10250 ENOG4105VEJ Heat shock protein HKO16_10260 ENOG4105Y3E Modulates RecA activity (By similarity) HKO16_10275 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HKO16_10295 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HKO16_10300 ENOG4105DZP Membrane-associated zinc metalloprotease HKO16_10310 ENOG4105KNE Phosphatidate cytidylyltransferase HKO16_10315 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HKO16_10340 ENOG4105CUX Signal transduction histidine kinase HKO16_10345 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HKO16_10400 ENOG4105CMR udp-glucose 4-epimerase HKO16_10405 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HKO16_10425 ENOG4105T38 integral membrane protein HKO16_10430 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKO16_10440 ENOG4105CVM Molybdenum cofactor synthesis domain protein HKO16_10445 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HKO16_10480 ENOG4108IFG nitrite reductase, (NAD(P)H) HKO16_10485 ENOG4107QZF nitrite reductase NADPH large subunit HKO16_10495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HKO16_10520 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HKO16_10525 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HKO16_10535 ENOG4105D8G Major Facilitator superfamily HKO16_10550 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HKO16_10615 ENOG4105UPP uncharacterized protein ydcA HKO16_10765 ENOG4105WXW Antirepressor HKO16_10910 ENOG4105CBC glutamate synthase HKO16_10940 ENOG4105C0A alcohol dehydrogenase HKO16_10950 ENOG4105HSS phospholipase C HKO16_10955 ENOG4107QMP dna polymerase iii subunits gamma and tau HKO16_10980 ENOG4105CHR reductase HKO16_10985 ENOG4105CHU acetyl-coa acetyltransferase HKO16_10995 ENOG4105C5Q Transcriptional regulator HKO16_11005 ENOG4108NIW Leucine export protein LeuE HKO16_11010 ENOG4105EW9 transcriptional regulator AsnC family HKO16_11015 ENOG4105DKK Benzoate HKO16_11025 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HKO16_11050 ENOG41081QV Universal stress protein HKO16_11055 ENOG4105C5H ABC transporter HKO16_11075 ENOG4105CNM Receptor HKO16_11105 ENOG4105CUY Mechanosensitive ion channel HKO16_11115 ENOG4105R8C Transcriptional regulator HKO16_11125 ENOG4105EW9 transcriptional regulator AsnC family HKO16_11130 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HKO16_11155 ENOG4108D1K outer membrane usher protein HKO16_11170 ENOG4105CD8 aminopeptidase N HKO16_11195 ENOG4107QUV Domain protein HKO16_11200 ENOG4105C0A alcohol dehydrogenase HKO16_11210 ENOG4107RR1 TRANSCRIPTIONal HKO16_11220 ENOG4107R55 ethanolamine transporter HKO16_11225 ENOG4105CPD ethanolamine ammonia-lyase HKO16_11230 ENOG4107FQ9 ethanolamine ammonia-lyase HKO16_11235 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HKO16_11240 ENOG4105CX6 glutaminyL-tRNA synthetase HKO16_11260 ENOG4108RCM Nitroreductase HKO16_11265 ENOG4108TZV Membrane HKO16_11270 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HKO16_11280 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HKO16_11285 ENOG4105K8N protein family UPF0079, ATPase HKO16_11320 ENOG4105DZ2 Transcriptional regulator HKO16_11335 ENOG4105F27 Major Facilitator HKO16_11340 ENOG4105EYW Ion transport protein HKO16_11350 ENOG4107QIJ Aconitate hydratase 2 HKO16_11365 ENOG4105CFU surface antigen HKO16_11370 ENOG4107S74 Lysophospholipid transporter LplT HKO16_11385 ENOG4105CFQ glutamine synthetase HKO16_11390 ENOG4105EEX Two component transcriptional regulator (Winged helix family HKO16_11395 ENOG4105C08 Histidine kinase HKO16_11400 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HKO16_11405 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HKO16_11410 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HKO16_11420 ENOG4105KRF dihydroneopterin aldolase HKO16_11430 ENOG4105D06 uba thif-type nad fad binding protein HKO16_11435 ENOG4108MEJ flavin reductase domain protein HKO16_11445 ENOG4105C1G acyl-Coa dehydrogenase HKO16_11460 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HKO16_11475 ENOG4105CC0 LysR family Transcriptional regulator HKO16_11490 ENOG4105DEN Luciferase family HKO16_11505 ENOG4105CND Glycosyl transferase, family 2 HKO16_11510 ENOG4107BJW polysaccharide deacetylase HKO16_11535 ENOG4105E2S oxidase) subunit II HKO16_11540 ENOG4105BZ9 Cytochrome C oxidase, subunit I HKO16_11545 ENOG4105CCU oxidase (Subunit III) HKO16_11550 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HKO16_11575 ENOG4105CDU Replicative dna helicase HKO16_11580 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HKO16_11630 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HKO16_11635 ENOG4105DC1 bifunctional purine biosynthesis protein purh HKO16_11640 ENOG4105C12 Phosphoribosylglycinamide synthetase HKO16_11650 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HKO16_11655 ENOG4108UMI ABC transporter, permease HKO16_11660 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HKO16_11670 ENOG4105CK2 sodium dicarboxylate symporter HKO16_11715 ENOG4105DY2 Paraquat-inducible protein b HKO16_11720 ENOG4105F1S paraquat-inducible protein a HKO16_11755 ENOG4105CSH Transporter HKO16_11805 ENOG4105JXH GntR family transcriptional regulator HKO16_11815 ENOG4105D6U Sodium Glutamate Symporter HKO16_11845 ENOG4105H4F exported protein HKO16_11880 ENOG4105C26 Dehydrogenase HKO16_11885 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HKO16_11890 ENOG4105EVZ LysR family transcriptional regulator HKO16_11915 ENOG4105D9P serine threonine protein kinase HKO16_11945 ENOG4105KTH gatB Yqey HKO16_11950 ENOG4105ERG peptidase m48, ste24p HKO16_11955 ENOG4105C5I Dehydrogenase HKO16_11970 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HKO16_12005 ENOG41069NU Nitroreductase HKO16_12015 ENOG4105C1J atp-dependent rna helicase HKO16_12020 ENOG4105VEQ Cold shock protein HKO16_12030 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKO16_12035 ENOG4105M08 Membrane HKO16_12065 ENOG4105CYB regulatoR HKO16_12070 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HKO16_12075 ENOG4105E0Y RtcB Protein HKO16_12095 ENOG4105CIN aminoacyl-histidine dipeptidase HKO16_12105 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HKO16_12110 ENOG4105CQC Prephenate dehydratase HKO16_12115 ENOG4105NIV Esterase HKO16_12120 ENOG4105C1G acyl-Coa dehydrogenase HKO16_12125 ENOG4105CK2 sodium dicarboxylate symporter HKO16_12130 ENOG4108I0Q anthranilate phosphoribosyltransferase HKO16_12135 ENOG4105VUT cytoplasmic protein HKO16_12140 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HKO16_12145 ENOG4105BZ4 penicillin-binding protein HKO16_12155 ENOG4105M6F mutator MutT protein HKO16_12165 ENOG4105DHQ Histidine kinase HKO16_12170 ENOG4105XJC Two component transcriptional regulator (Winged helix family HKO16_12180 ENOG4107QHF type ii secretion system protein e HKO16_12190 ENOG4108R96 Methyltransferase, YaeB family HKO16_12195 ENOG4105DP0 ferredoxin-NADP reductase HKO16_12200 ENOG4105JAB phenazine biosynthesis protein, phzf family HKO16_12205 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKO16_12210 ENOG4105CFP Peptidase U32 HKO16_12215 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HKO16_12225 ENOG4108JEH abc transporter atp-binding protein HKO16_12230 ENOG4106YG3 ABC transporter HKO16_12235 ENOG4105DSP amino acid AbC transporter HKO16_12240 ENOG4105E89 ABC transporter HKO16_12250 ENOG4105ENT Efflux transporter rnd family, mfp subunit HKO16_12260 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKO16_12295 ENOG4105DA5 (ABC) transporter HKO16_12300 ENOG4105E3A (ABC) transporter HKO16_12315 ENOG4105CNI cell division protein FtsW HKO16_12320 ENOG4105CVE Lytic murein transglycosylase HKO16_12360 ENOG4105CE9 30S ribosomal protein S2 HKO16_12365 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HKO16_12375 ENOG4107RNU major facilitator superfamily MFS_1 HKO16_12385 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HKO16_12390 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HKO16_12395 ENOG4107QPN acyl-Coa dehydrogenase HKO16_12410 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HKO16_12415 ENOG4105SYT Methylenetetrahydrofolate reductase HKO16_12420 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HKO16_12425 ENOG4105BZU Histidine kinase HKO16_12430 ENOG4105C6K Malic enzyme HKO16_12440 ENOG4105C0H protease HKO16_12445 ENOG4107QNR UPF0135 protein HKO16_12450 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKO16_12485 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HKO16_12500 ENOG4105DUX Transporter HKO16_12510 ENOG4105DDQ anthranilate synthase HKO16_12515 ENOG4105CD8 aminopeptidase N HKO16_12545 ENOG4105C7W Xanthine dehydrogenase HKO16_12555 ENOG4105EUJ GTP cyclohydrolase i HKO16_12575 ENOG4105NX3 Membrane HKO16_12610 ENOG4105BZ1 (ABC) transporter HKO16_12625 ENOG4105WQI isochorismatase HKO16_12630 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HKO16_12635 ENOG4105C0W non-ribosomal peptide synthetase HKO16_12655 ENOG4108IPW abc transporter atp-binding protein HKO16_12670 ENOG4105CEY Amp-dependent synthetase and ligase HKO16_12685 ENOG4105WWK YheO domain protein HKO16_12695 ENOG4105C2I pirin domain protein HKO16_12745 ENOG4105D74 hydrolase HKO16_12750 ENOG4107RN6 Monooxygenase HKO16_12760 ENOG4105CR8 Transcriptional regulator HKO16_12765 ENOG4105CHJ isochorismatase hydrolase HKO16_12805 ENOG4105VCD cytoplasmic protein HKO16_12810 ENOG4105D22 carbon starvation protein HKO16_12820 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HKO16_12830 ENOG41066DG (EAL) domain protein HKO16_12840 ENOG4105DHU Bile acid HKO16_12855 ENOG4105DAN ATP-dependent protease HKO16_12860 ENOG4105EJC lysr family transcriptional regulator HKO16_12865 ENOG4108K5P (LipO)protein HKO16_12885 ENOG4105DZ1 carboxypeptidase HKO16_12890 ENOG4108Z0R Transferase HKO16_12910 ENOG4107QTF adenylosuccinate lyase HKO16_12925 ENOG4105ERU peptidase HKO16_12930 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HKO16_12940 ENOG4105C8U phosphate abc transporter HKO16_12945 ENOG4105CVA phosphate HKO16_12950 ENOG4105C85 amino acid HKO16_12955 ENOG4107RA9 decarboxylase HKO16_12960 ENOG4105F7P transcriptional regulator AsnC family HKO16_12970 ENOG4105DY8 decarboxylase HKO16_12975 ENOG4108JPW Aminotransferase HKO16_12990 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HKO16_13000 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HKO16_13015 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HKO16_13020 ENOG4105D3G Pseudouridine synthase HKO16_13035 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HKO16_13065 ENOG4105JAB phenazine biosynthesis protein, phzf family HKO16_13070 ENOG4108ETY sodium dicarboxylate symporter HKO16_13075 ENOG4105EGI Transcriptional regulator HKO16_13080 ENOG4105CBP Major Facilitator HKO16_13105 ENOG4108R99 pseudouridine synthase HKO16_13110 ENOG4105E9K Isocitrate dehydrogenase HKO16_13120 ENOG4105DZ1 carboxypeptidase HKO16_13125 ENOG4105CEP NADH dehydrogenase HKO16_13130 ENOG4108YZY peptidylprolyl cis-trans isomerase HKO16_13135 ENOG4105CVP deoxyribo-dipyrimidine photolyase HKO16_13150 ENOG4107R8N Glycosyl transferase, family 2 HKO16_13180 ENOG4105EA8 2-Nitropropane dioxygenase HKO16_13185 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HKO16_13190 ENOG4107QS8 (LipO)protein HKO16_13225 ENOG4105DTR rard protein HKO16_13235 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HKO16_13245 ENOG4105BZU Histidine kinase HKO16_13265 ENOG4105F7F Chaperone HKO16_13295 ENOG4105EMU Dehydrogenase HKO16_13300 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HKO16_13305 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HKO16_13310 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HKO16_13320 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HKO16_13335 ENOG4105C3F Signal peptidase i HKO16_13345 ENOG41068WN HKO16_13355 ENOG4105C0H protease HKO16_13360 ENOG4108IYU L-aspartate oxidase HKO16_13375 ENOG4105HHA aminodeoxychorismate lyase HKO16_13380 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HKO16_13385 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HKO16_13395 ENOG4108I5D sulfate abc transporter HKO16_13405 ENOG4108IJ6 ABC transporter HKO16_13410 ENOG4107R11 Transcriptional regulator HKO16_13425 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HKO16_13430 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HKO16_13445 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HKO16_13460 ENOG4108UKI Enoyl-CoA hydratase HKO16_13530 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HKO16_13535 ENOG4108JJA ABC, transporter HKO16_13540 ENOG4107QI1 Mate efflux family protein HKO16_13580 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HKO16_13585 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HKO16_13590 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HKO16_13595 ENOG4105CEY Amp-dependent synthetase and ligase HKO16_13600 ENOG4105C0W non-ribosomal peptide synthetase HKO16_13605 ENOG4105C0W non-ribosomal peptide synthetase HKO16_13610 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HKO16_13615 ENOG4105WQI isochorismatase HKO16_13620 ENOG4105E4F Isochorismate synthase HKO16_13645 ENOG4108ETH Formylglycinamide ribotide synthetase HKO16_13665 ENOG4105CH2 amidohydrolase HKO16_13670 ENOG4107YD3 Thioesterase HKO16_13675 ENOG4105E02 MotA TolQ exbB proton channel HKO16_13680 ENOG4105M8F Biopolymer transport protein exbD tolR HKO16_13690 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HKO16_13695 ENOG4105KCK Peptidoglycan-associated lipoprotein HKO16_13745 ENOG4105C02 permease HKO16_13755 ENOG4108V3E phosphoribosylglycinamide formyltransferase HKO16_13760 ENOG4107R6F Alpha Beta Hydrolase Fold protein HKO16_13765 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HKO16_13775 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HKO16_13780 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HKO16_13785 ENOG4105D60 lipoprotein releasing system transmembrane protein HKO16_13820 ENOG4107KET secretion protein, HlyD family HKO16_13855 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKO16_13860 ENOG4105C10 Electron transfer flavoprotein HKO16_13865 ENOG4105BZJ Electron transfer flavoprotein HKO16_13870 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HKO16_13875 ENOG4105N14 lysine exporter protein LysE YggA HKO16_13885 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HKO16_13895 ENOG4105C85 amino acid HKO16_13900 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HKO16_13910 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HKO16_13925 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HKO16_13930 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HKO16_13935 ENOG4105BZW Glycerate kinase HKO16_14005 ENOG4105YCT UPF0386 protein HKO16_14015 ENOG4105CEY Amp-dependent synthetase and ligase HKO16_14030 ENOG4108RRZ Transcription elongation factor GreB HKO16_14050 ENOG4105E4C Lytic transglycosylase catalytic HKO16_14065 ENOG4105BZS acriflavin resistance protein HKO16_14070 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HKO16_14080 ENOG41080IJ Diacylglycerol kinase HKO16_14095 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HKO16_14110 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HKO16_14115 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HKO16_14120 ENOG4105CSH Transporter HKO16_14170 ENOG4105EEI dihydropteroate synthase HKO16_14175 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HKO16_14185 ENOG4105HBR Rna-binding protein HKO16_14200 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HKO16_14205 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HKO16_14215 ENOG4108IG5 Transcriptional regulator HKO16_14220 ENOG4108UQ8 endoribonuclease L-psp HKO16_14230 ENOG41080TK Universal stress protein HKO16_14245 ENOG4105PNM synthesis protein HKO16_14260 ENOG4105EEQ Na H antiporter HKO16_14265 ENOG4105CGZ zinc metallopeptidase HKO16_14270 ENOG4105CKW Inner membrane protein yedI HKO16_14280 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HKO16_14290 ENOG4107QN2 dihydrolipoyl dehydrogenase HKO16_14295 ENOG4105C7S Dehydrogenase HKO16_14300 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HKO16_14315 ENOG4105E33 succinate dehydrogenase HKO16_14325 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HKO16_14330 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HKO16_14365 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HKO16_14370 ENOG41084BA UPF0250 protein HKO16_14375 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HKO16_14390 ENOG4105CUB amino acid HKO16_14400 ENOG4105KVH Transcriptional regulator HKO16_14405 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HKO16_14410 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HKO16_14425 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HKO16_14455 ENOG410841Q phosphoesterase PA-phosphatase related protein HKO16_14460 ENOG4105C1P efflux transporter, rnd family, mfp subunit HKO16_14465 ENOG4105BZS acriflavin resistance protein HKO16_14470 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HKO16_14475 ENOG4105K8R UPF0145 protein HKO16_14480 ENOG4105K8R UPF0145 protein HKO16_14500 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HKO16_14520 ENOG4108M0I Transcriptional regulator HKO16_14535 ENOG4105DHQ Histidine kinase HKO16_14540 ENOG4105XJC Two component transcriptional regulator (Winged helix family HKO16_14545 ENOG4105DIJ Phosphoethanolamine transferase HKO16_14565 ENOG4105D78 K07001 NTE family protein HKO16_14580 ENOG4105MSB protein, conserved in bacteria HKO16_14585 ENOG4105CTB Polyprenyl synthetase HKO16_14590 ENOG4105C7F AcnD-accessory protein PrpF HKO16_14595 ENOG4105C85 amino acid HKO16_14615 ENOG4105CF7 AraC family transcriptional regulator HKO16_14640 ENOG4108X0B nad(p)h dehydrogenase (quinone) HKO16_14650 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein HKO16_14660 ENOG4105D8T Acyltransferase HKO16_14670 ENOG4105C03 ribonuclease HKO16_14675 ENOG4108Z03 MAF-like protein HKO16_14680 ENOG4105VQ7 Rod shape-determining protein MreD HKO16_14685 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HKO16_14695 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HKO16_14705 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HKO16_14730 ENOG4105C9K Endothelin-converting enzyme 1 HKO16_14740 ENOG4105C7B Threonine dehydratase HKO16_14745 ENOG4105D78 K07001 NTE family protein HKO16_14750 ENOG4105BZG amino acid carrier protein HKO16_14770 ENOG4105C2C drug resistance transporter, Bcr CflA HKO16_14775 ENOG4105EM2 membrane HKO16_14825 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HKO16_14830 ENOG4105WD1 Membrane HKO16_14840 ENOG4107PEH Entericidin EcnA/B family HKO16_14855 ENOG4105CBS Chea signal transduction histidine kinase HKO16_14860 ENOG4105C8Q Methyl-accepting chemotaxis HKO16_14865 ENOG4108ZGA chew protein HKO16_14870 ENOG4105M3Z response regulator HKO16_14875 ENOG4108UNF response regulator HKO16_14900 ENOG4105KWI UPF0339 protein HKO16_14905 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HKO16_14910 ENOG4105K78 MarR family Transcriptional regulator HKO16_14920 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HKO16_14925 ENOG4105T95 Thiol disulfide interChange protein HKO16_14935 ENOG4108N2Y auxin Efflux HKO16_14940 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKO16_14945 ENOG4105CHB tonB-dependent Receptor HKO16_14950 ENOG4108VX5 3-methyladenine DNA glycosylase HKO16_14960 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HKO16_14975 ENOG4105CI3 gtp-binding protein typa HKO16_14980 ENOG4105C2W permease HKO16_14990 ENOG4108IQI permease HKO16_14995 ENOG4105E0Y RtcB Protein HKO16_15015 ENOG4105CHU acetyl-coa acetyltransferase HKO16_15035 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HKO16_15040 ENOG4105DZG Dehydrogenase HKO16_15045 ENOG4105TW1 Carbohydrate-selective porin OprB HKO16_15055 ENOG4108R6W Transcriptional regulator, ARAC family HKO16_15060 ENOG4105CHU acetyl-coa acetyltransferase HKO16_15080 ENOG41082BV acetyltransferase HKO16_15090 ENOG4108UT2 hemolysin iii HKO16_15095 ENOG4105CSH Transporter HKO16_15110 ENOG4105D3R alkyl hydroperoxide reductase HKO16_15130 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HKO16_15175 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HKO16_15180 ENOG4108WBT adenosyltransferase HKO16_15200 ENOG4105CNG UPF0061 protein HKO16_15205 ENOG4105E3W Two component transcriptional regulator (Winged helix family HKO16_15210 ENOG4105EB3 Histidine kinase HKO16_15220 ENOG4105CSU acyl-Coa dehydrogenase HKO16_15225 ENOG4105CSU acyl-Coa dehydrogenase HKO16_15230 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HKO16_15250 ENOG4105UGU tonB-dependent Receptor HKO16_15275 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HKO16_15290 ENOG4108PQP glycosyl transferase group 1 HKO16_15300 ENOG4107BJW polysaccharide deacetylase HKO16_15315 ENOG4105CM2 brancheD-chain amino acid aminotransferase HKO16_15320 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HKO16_15325 ENOG4105BZU Histidine kinase HKO16_15340 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HKO16_15395 ENOG4105VIE preprotein translocase, subunit YajC HKO16_15400 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HKO16_15405 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HKO16_15410 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HKO16_15420 ENOG4105FFC UPF0187 protein HKO16_15425 ENOG4105DB7 PHP domain protein HKO16_15435 ENOG4105K9H YciI-like protein HKO16_15460 ENOG4105DFP Integrase HKO16_15500 ENOG4105CE1 Ferrous iron transport protein b HKO16_15510 ENOG4108IJF Heavy metal efflux pump, CzcA HKO16_15535 ENOG4105E3B Multicopper oxidase HKO16_15550 ENOG4105GR3 Histidine kinase HKO16_15635 ENOG4105XWI UPF0304 protein HKO16_15670 ENOG4105NAU thioesterase Superfamily protein HKO16_15680 ENOG4107U2T alpha beta HKO16_15730 ENOG4108KHX Diguanylate cyclase HKO16_15735 ENOG4105UYK outer membrane protein a HKO16_15745 ENOG4107RZC phospholipase d HKO16_15755 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HKO16_15775 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HKO16_15780 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HKO16_15785 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HKO16_15795 ENOG4108UJD 30S ribosomal protein S9 HKO16_15800 ENOG4107MKT Stringent starvation protein a HKO16_15805 ENOG4105KB2 stringent starvation protein b HKO16_15825 ENOG4105C1G acyl-Coa dehydrogenase HKO16_15830 ENOG4107QX3 carboxylase HKO16_15845 ENOG4108RZE Tetr family transcriptional regulator HKO16_15850 ENOG4105C1G acyl-Coa dehydrogenase HKO16_15895 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HKO16_15900 ENOG4105D6S protein involved in catabolism of external DNA HKO16_15930 ENOG4105E4C Lytic transglycosylase catalytic HKO16_15940 ENOG4105C9A Phoh family HKO16_15970 ENOG4105CS1 NAD(P)H quinone oxidoreductase HKO16_15975 ENOG4107S2Z UPF0761 membrane protein HKO16_15985 ENOG4108K2B transcriptional regulator HKO16_15990 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HKO16_16035 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HKO16_16040 ENOG4105DGW oligopeptidase A HKO16_16045 ENOG4105VKU nucleicacid-binding protein HKO16_16080 ENOG4105C1G acyl-Coa dehydrogenase HKO16_16120 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HKO16_16230 ENOG41089BK Glutamine amido-transferase HKO16_16240 ENOG4105D7A ATP-binding protein HKO16_16255 ENOG4105KPV Transcriptional regulator HKO16_16270 ENOG4105CK2 sodium dicarboxylate symporter HKO16_16275 ENOG4105C29 acyl-CoA thioesterase HKO16_16295 ENOG4105CB5 ATP-dependent DNA helicase recG HKO16_16300 ENOG4105MJ2 Competence protein HKO16_16310 ENOG4108URH decarboxylase HKO16_16315 ENOG4105D7N magnesium and cobalt transport protein CorA HKO16_16325 ENOG4105E3I toluene tolerance HKO16_16335 ENOG4105CY3 ABC transporter, permease HKO16_16340 ENOG4105DHJ ABC, transporter HKO16_16350 ENOG4105C1J atp-dependent rna helicase HKO16_16355 ENOG4105ECY inositol monophosphatase HKO16_16370 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HKO16_16385 ENOG4105CSU acyl-Coa dehydrogenase HKO16_16395 ENOG41067S9 phage shock protein C, PspC HKO16_16400 ENOG4105W87 Cbs domain HKO16_16490 ENOG4105C26 Dehydrogenase HKO16_16500 ENOG4105C8Y Acetylornithine aminotransferase HKO16_16505 ENOG4105D82 Glutamate dehydrogenase HKO16_16510 ENOG4108IQI permease HKO16_16540 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HKO16_16545 ENOG4105IPI Membrane HKO16_16550 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HKO16_16555 ENOG4105EM2 membrane HKO16_16560 ENOG4107QF7 multi-drug HKO16_16570 ENOG4105NF4 modulator of drug activity HKO16_16575 ENOG4105VRH Antibiotic biosynthesis monooxygenase HKO16_16585 ENOG4105CQB FAD linked oxidase domain protein HKO16_16590 ENOG4108JQ1 Dehydrogenase HKO16_16615 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HKO16_16620 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) HKO16_16625 ENOG4107IFA Lipase (EC 3.1.1.3) HKO16_16640 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HKO16_16690 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HKO16_16705 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HKO16_16710 ENOG4105KME endoribonuclease L-psp HKO16_16720 ENOG4108UQY Iron-storage protein HKO16_16725 ENOG4108YSG O-Antigen polymerase HKO16_16740 ENOG4105HA9 of methanol dehydrogenase type HKO16_16745 ENOG4108V0P LemA family HKO16_16755 ENOG4105BZ8 glutamate synthase HKO16_16760 ENOG4105CBC glutamate synthase HKO16_16780 ENOG4105E4G Type IV pilus HKO16_16805 ENOG4108JQC penicillin-binding protein 1A HKO16_16810 ENOG4105DHI Methyltransferase HKO16_16825 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HKO16_16830 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HKO16_16835 ENOG4105CJN penicillin-binding protein HKO16_16850 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HKO16_16875 ENOG4108IQI permease HKO16_16940 ENOG4105C5H ABC transporter HKO16_16965 ENOG4105PDP Short chain dehydrogenase HKO16_16970 ENOG4105CHH sulfate transporter HKO16_16975 ENOG4105BZM domain protein HKO16_16985 ENOG4105E0F Histidine kinase HKO16_16995 ENOG4105CYC Transferase HKO16_17000 ENOG4108R6G acetyltransferase HKO16_17025 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HKO16_17055 ENOG41061CK Antibiotic biosynthesis monooxygenase HKO16_17070 ENOG4105CUV Homoserine Kinase HKO16_17125 ENOG4108UQN AraC family transcriptional regulator HKO16_17130 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HKO16_17150 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HKO16_17155 ENOG4105KVH Transcriptional regulator HKO16_17185 ENOG4105KVH Transcriptional regulator HKO16_17205 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HKO16_17230 ENOG4106NZI LysR family Transcriptional regulator HKO16_17235 ENOG4105D94 Major Facilitator Superfamily HKO16_17270 ENOG4105EUB pirin domain protein HKO16_17275 ENOG4105CHJ isochorismatase hydrolase HKO16_17285 ENOG4105C26 Dehydrogenase HKO16_17290 ENOG4108JPW Aminotransferase HKO16_17300 ENOG4105C85 amino acid HKO16_17310 ENOG4108UMN azlc family HKO16_17320 ENOG4108UUM single-stranded DNA-binding protein HKO16_17325 ENOG4107RDB Major Facilitator HKO16_17335 ENOG4105DWF phosphomethylpyrimidine kinase HKO16_17340 ENOG4105RA2 Membrane HKO16_17350 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HKO16_17355 ENOG4108WUH Transcriptional regulator, TetR family HKO16_17360 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HKO16_17365 ENOG4105BZU Histidine kinase HKO16_17375 ENOG4105C94 Transporter HKO16_17385 ENOG4107QN1 sodium solute HKO16_17390 ENOG41062QD Membrane HKO16_17395 ENOG4105BZU Histidine kinase HKO16_17410 ENOG4108UZX fmn reductase HKO16_17415 ENOG4105FBW Monooxygenase HKO16_17425 ENOG4108W2Y isochorismatase HKO16_17430 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HKO16_17440 ENOG4105D64 Mechanosensitive ion channel HKO16_17450 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HKO16_17455 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HKO16_17475 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HKO16_17490 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HKO16_17505 ENOG4105E0K tonB-dependent siderophore receptor HKO16_17520 ENOG4107QSN dihydrolipoamide acetyltransferase HKO16_17525 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HKO16_17530 ENOG41063SB peptidase HKO16_17545 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HKO16_17550 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HKO16_17555 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HKO16_17575 ENOG4105D7Z glutathione synthase HKO16_17600 ENOG4105CGK Exodeoxyribonuclease III HKO16_17605 ENOG4105KUZ arsenate reductase HKO16_17620 ENOG4105BZU Histidine kinase HKO16_17625 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HKO16_17655 ENOG41084YZ Hydrolase HKO16_17670 ENOG41061H0 Monooxygenase HKO16_17680 ENOG4108Z2U ureidoglycolate hydrolase HKO16_17685 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKO16_17690 ENOG4105IPS esterase HKO16_17805 ENOG4105D6J arsenicaL-resistance protein HKO16_17845 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HKO16_17895 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HKO16_17925 ENOG4105CHH sulfate transporter HKO16_17980 ENOG4105C0P Mg chelatase subunit ChlI HKO16_17985 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HKO16_17995 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HKO16_18005 ENOG41090KI Outer membrane porin HKO16_18010 ENOG4105F0N pyrophosphate phospho-hydrolase HKO16_18025 ENOG4105CEY Amp-dependent synthetase and ligase HKO16_18030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HKO16_18035 ENOG41079KZ Major Facilitator Superfamily HKO16_18040 ENOG4105EN6 Membrane HKO16_18045 ENOG4105K5B UPF0225 protein HKO16_18050 ENOG4105EE5 Membrane protein terC HKO16_18055 ENOG4108URH decarboxylase HKO16_18060 ENOG4105C0R drug resistance transporter emrb qaca subfamily HKO16_18070 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HKO16_18085 ENOG4105CCT upf0313 protein HKO16_18105 ENOG4105CS1 NAD(P)H quinone oxidoreductase HKO16_18115 ENOG4105C6T cysteine synthase HKO16_18150 ENOG4105Y7M Transcriptional regulator, TetR family HKO16_18185 ENOG4105C79 DNA protecting protein DprA HKO16_18200 ENOG4108IND Tetr family transcriptional regulator HKO16_18205 ENOG4107RTG Major Facilitator superfamily HKO16_18215 ENOG4108V06 Glutathione peroxidase HKO16_18225 ENOG41090VV Protein of unknown function (DUF2846) HKO16_18285 ENOG4105FDK ABC transporter HKO16_18290 ENOG4105FAV ABC, transporter HKO16_18295 ENOG410829K Lysine exporter protein (Lyse ygga) HKO16_18300 ENOG4105EZR dyp-type peroxidase family protein HKO16_18305 ENOG4107R1I NAD-dependent malic enzyme HKO16_18330 ENOG4105EUB pirin domain protein HKO16_18350 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HKO16_18355 ENOG4106MP8 UPF0754 membrane protein HKO16_18360 ENOG4108VBZ doxx family HKO16_18365 ENOG4105DQR SNARE associated Golgi HKO16_18380 ENOG4107QJE Chromosome Partitioning Protein HKO16_18390 ENOG4107PSF BolA-like protein HKO16_18435 ENOG4105C1G acyl-Coa dehydrogenase HKO16_18440 ENOG4107RCI amp-dependent synthetase and ligase HKO16_18460 ENOG4105CSH Transporter HKO16_18465 ENOG4105E39 Enoyl-CoA hydratase HKO16_18470 ENOG4105E39 Enoyl-CoA hydratase HKO16_18475 ENOG4105C1G acyl-Coa dehydrogenase HKO16_18485 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HKO16_18490 ENOG4105C26 Dehydrogenase HKO16_18500 ENOG4105C85 amino acid HKO16_18505 ENOG4105C85 amino acid HKO16_18510 ENOG4105M4H endoribonuclease L-psp HKO16_18525 ENOG4105EW9 transcriptional regulator AsnC family HKO16_18550 ENOG4105D3G Pseudouridine synthase HKO16_18630 ENOG4108I0Z Aconitate hydratase HKO16_18635 ENOG4105BZN citrate synthase HKO16_18640 ENOG4105CR4 methylisocitrate lyase HKO16_18645 ENOG4105DRR Transcriptional regulator, GntR family HKO16_18655 ENOG4105CGF Aromatic amino acid aminotransferase HKO16_18660 ENOG4105CXG d-lactate dehydrogenase HKO16_18670 ENOG41073TP transcriptional regulator HKO16_18675 ENOG4105DAA L-lactate HKO16_18680 ENOG4107QKV phosphomannomutase HKO16_18685 ENOG4105CMR udp-glucose 4-epimerase HKO16_18695 ENOG4105C6Y Udp-glucose 6-dehydrogenase HKO16_18700 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HKO16_18705 ENOG4105D3Q Sugar transferase HKO16_18710 ENOG4108RYC glycosyltransferase HKO16_18715 ENOG4105CG5 Glycosyl transferase (Group 1 HKO16_18730 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HKO16_18735 ENOG4108UW5 maltose o-acetyltransferase HKO16_18745 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HKO16_18750 ENOG4105J5G Transferase hexapeptide repeat containing protein HKO16_18755 ENOG4107R5Z Oxidoreductase domain protein HKO16_18760 ENOG4107QQG Dehydrogenase HKO16_18765 ENOG4105DAY polysaccharide export protein HKO16_18775 ENOG4105D75 Capsular exopolysaccharide family HKO16_18780 ENOG4108V1T peptidylprolyl cis-trans isomerase HKO16_18785 ENOG4108V1T peptidylprolyl cis-trans isomerase HKO16_18790 ENOG4105CJR Integral membrane protein (MviN HKO16_18795 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HKO16_18800 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HKO16_18810 ENOG4105HSS phospholipase C HKO16_18840 ENOG41062JF Transcriptional regulator HKO16_18845 ENOG4108Z33 Thiol disulfide Interchange Protein HKO16_18855 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HKO16_18860 ENOG4105UBK short-chain dehydrogenase reductase HKO16_18875 ENOG4107QZM n-acetylglutamate synthase HKO16_18880 ENOG4105GVF (ABC) transporter HKO16_18885 ENOG4105GVF (ABC) transporter HKO16_18890 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HKO16_18895 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HKO16_18900 ENOG4108VM9 ABC, transporter HKO16_18905 ENOG4108R86 Transcriptional regulator HKO16_18910 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HKO16_18920 ENOG4105DTN riboflavin biosynthesis protein ribF HKO16_18925 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HKO16_18935 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HKO16_18975 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HKO16_19030 ENOG4105CVE Lytic murein transglycosylase HKO16_19035 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HKO16_19040 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HKO16_19050 ENOG4105DFU Cell wall formation (By similarity) HKO16_19060 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HKO16_19065 ENOG4105DU1 integral membrane protein, terc HKO16_19075 ENOG4106032 Glutathionylspermidine synthase HKO16_19085 ENOG4107QUY Guanine deaminase HKO16_19090 ENOG4108UGV hypoxanthine phosphoribosyltransferase HKO16_19100 ENOG4105T95 Thiol disulfide interChange protein HKO16_19105 ENOG4105PGM cation diffusion facilitator family transporter HKO16_19120 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HKO16_19150 ENOG4105RQF LysR family Transcriptional regulator HKO16_19185 ENOG4105XUP Phage derived protein Gp49-like (DUF891) HKO16_19260 ENOG4107ZQV short-chain dehydrogenase reductase HKO16_19275 ENOG4105UGU tonB-dependent Receptor