locus-tag	class	description
HKO16_00010	COG0592	DNA-directed DNA polymerase activity
HKO16_00020	COG0187	DNA topoisomerase II activity
HKO16_00030	COG0586	Pfam SNARE associated Golgi protein
HKO16_00035	COG0488	(ABC) transporter
HKO16_00060	COG0596	Alpha beta hydrolase
HKO16_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HKO16_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HKO16_00110	COG0733	neurotransmitter:sodium symporter activity
HKO16_00150	COG2233	PERMEase
HKO16_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_00200	COG2814	Major facilitator Superfamily
HKO16_00205	COG0656	L-ascorbic acid biosynthetic process
HKO16_00210	COG0583	DNA-binding transcription factor activity
HKO16_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_00230	COG1064	alcohol dehydrogenase
HKO16_00235	COG2818	Glycosylase
HKO16_00250	COG1194	a g-specific adenine glycosylase
HKO16_00270	COG2983	Belongs to the UPF0260 family
HKO16_00275	COG2133	pyrroloquinoline quinone binding
HKO16_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HKO16_00285	COG2116	formate transmembrane transporter activity
HKO16_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKO16_00310	COG1335	isochorismatase
HKO16_00315	COG0385	Bile acid
HKO16_00320	COG0534	Mate efflux family protein
HKO16_00325	COG1683	Conserved Protein
HKO16_00345	COG0625	glutathione transferase activity
HKO16_00355	COG1113	amino acid transport
HKO16_00365	COG0523	cobalamin synthesis protein
HKO16_00375	COG2188	Transcriptional regulator
HKO16_00405	COG0010	Belongs to the arginase family
HKO16_00425	COG1280	lysine exporter protein (LysE YggA)
HKO16_00440	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HKO16_00450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HKO16_00455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HKO16_00500	COG0753	catalase activity
HKO16_00550	COG0534	Mate efflux family protein
HKO16_00555	COG0436	Aminotransferase
HKO16_00560	COG2733	membrane
HKO16_00575	COG2918	glutathione biosynthetic process
HKO16_00610	COG0640	Transcriptional regulator
HKO16_00635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HKO16_00710	COG1525	nuclease
HKO16_00830	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HKO16_00880	COG1192	Involved in chromosome partitioning
HKO16_00895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKO16_00925	COG0739	heme binding
HKO16_01095	COG0501	Belongs to the peptidase M48B family
HKO16_01155	COG0589	response to stress
HKO16_01160	COG0659	secondary active sulfate transmembrane transporter activity
HKO16_01170	COG0606	chelatase, subunit chli
HKO16_01180	COG0347	Belongs to the P(II) protein family
HKO16_01185	COG0004	ammonium transporteR
HKO16_01195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKO16_01195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HKO16_01235	COG0795	lipopolysaccharide-transporting ATPase activity
HKO16_01240	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HKO16_01245	COG0793	Belongs to the peptidase S41A family
HKO16_01260	COG2197	response regulator
HKO16_01270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HKO16_01280	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKO16_01285	COG4974	Belongs to the 'phage' integrase family
HKO16_01310	COG0772	Belongs to the SEDS family
HKO16_01315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKO16_01320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HKO16_01325	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HKO16_01350	COG0697	spore germination
HKO16_01355	COG1538	Outer membrane efflux protein
HKO16_01375	COG3275	phosphorelay sensor kinase activity
HKO16_01385	COG0181	hydroxymethylbilane synthase activity
HKO16_01435	COG1716	ATPase activity
HKO16_01440	COG0546	phosphoglycolate phosphatase activity
HKO16_01535	COG0596	Alpha beta hydrolase
HKO16_01540	COG2056	Na+-H+ antiporter family
HKO16_01555	COG0326	Molecular chaperone. Has ATPase activity
HKO16_01570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HKO16_01635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HKO16_01640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKO16_01640	COG2169	Transcriptional regulator
HKO16_01670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HKO16_01680	COG0497	DNA recombination
HKO16_01695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKO16_01705	COG0237	dephospho-CoA kinase activity
HKO16_01750	COG0195	Participates in both transcription termination and antitermination
HKO16_01770	COG2212	antiporter activity
HKO16_01780	COG0651	ATP synthesis coupled electron transport
HKO16_01785	COG1006	Multisubunit Na H antiporter MnhC subunit
HKO16_01790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKO16_01790	COG2111	Na H antiporter
HKO16_01805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HKO16_01825	COG2226	methyltransferase
HKO16_01845	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HKO16_01850	COG1074	ATP-dependent DNA helicase activity
HKO16_01855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKO16_01875	COG0598	Magnesium transport protein CorA
HKO16_01880	COG0789	Transcriptional regulator
HKO16_01885	COG0484	heat shock protein binding
HKO16_01900	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKO16_01900	COG0475	glutathione-regulated potassium exporter activity
HKO16_01905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HKO16_01925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKO16_01935	COG4535	Mg2 and Co2 transporter CorC
HKO16_01940	COG0425	Belongs to the sulfur carrier protein TusA family
HKO16_01950	COG0644	oxidoreductase
HKO16_01950	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HKO16_01960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HKO16_01975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKO16_01980	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HKO16_02015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HKO16_02030	COG0534	Mate efflux family protein
HKO16_02040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HKO16_02045	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_02050	COG0583	DNA-binding transcription factor activity
HKO16_02065	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_02070	COG1530	ribonuclease E activity
HKO16_02085	COG0546	phosphoglycolate phosphatase activity
HKO16_02090	COG2378	regulation of single-species biofilm formation
HKO16_02095	COG0625	glutathione transferase activity
HKO16_02105	COG0583	DNA-binding transcription factor activity
HKO16_02160	COG0473	3-isopropylmalate dehydrogenase activity
HKO16_02215	COG1301	dicarboxylic acid transport
HKO16_02225	COG1560	Kdo2-lipid A biosynthetic process
HKO16_02230	COG1280	lysine exporter protein (LysE YggA)
HKO16_02240	COG2900	Belongs to the SlyX family
HKO16_02250	COG1733	regulation of RNA biosynthetic process
HKO16_02275	COG0210	DNA helicase
HKO16_02280	COG0724	RNA recognition motif
HKO16_02300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HKO16_02300	COG4651	solute:proton antiporter activity
HKO16_02325	COG0788	formyltetrahydrofolate deformylase activity
HKO16_02425	COG2813	Specifically methylates the guanine in position
HKO16_02425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKO16_02445	COG4774	siderophore transport
HKO16_02455	COG0740	serine-type endopeptidase activity
HKO16_02475	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HKO16_02475	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HKO16_02480	COG0857	belongs to the CobB CobQ family
HKO16_02480	COG0280	phosphate acetyltransferase
HKO16_02485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HKO16_02495	COG0800	Aldolase
HKO16_02505	COG3265	gluconokinase activity
HKO16_02510	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_02520	COG2267	carboxylic ester hydrolase activity
HKO16_02535	COG0793	Belongs to the peptidase S41A family
HKO16_02570	COG1426	Protein conserved in bacteria
HKO16_02615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKO16_02625	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_02630	COG1216	Glycosyl transferase, family 2
HKO16_02640	COG2986	histidine ammonia-lyase
HKO16_02680	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_02685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HKO16_02705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HKO16_02715	COG1162	GTPase activity
HKO16_02720	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HKO16_02735	COG1538	Outer membrane efflux protein
HKO16_02740	COG0577	efflux transmembrane transporter activity
HKO16_02740	COG1136	(ABC) transporter
HKO16_02745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_02770	COG0028	Belongs to the TPP enzyme family
HKO16_02775	COG0440	acetolactate synthase activity
HKO16_02805	COG3501	Rhs element vgr protein
HKO16_02825	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HKO16_02840	COG0084	hydrolase, TatD family'
HKO16_02850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HKO16_02860	COG0583	DNA-binding transcription factor activity
HKO16_02870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKO16_02875	COG2814	Major facilitator Superfamily
HKO16_02885	COG0697	spore germination
HKO16_02915	COG3622	Belongs to the hyi family
HKO16_02920	COG2084	Dehydrogenase
HKO16_02925	COG1024	Enoyl-CoA hydratase
HKO16_02930	COG2205	protein histidine kinase activity
HKO16_02930	COG0784	Response regulator, receiver
HKO16_02930	COG5002	protein histidine kinase activity
HKO16_02950	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKO16_02960	COG3956	TIGRFAM MazG family protein
HKO16_02965	COG1555	photosystem II stabilization
HKO16_02970	COG0617	tRNA 3'-terminal CCA addition
HKO16_02975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HKO16_02995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKO16_03000	COG3028	Belongs to the UPF0307 family
HKO16_03005	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_03020	COG0625	glutathione transferase activity
HKO16_03025	COG1238	metal cluster binding
HKO16_03065	COG0072	phenylalanine-tRNA ligase activity
HKO16_03095	COG0248	Ppx GppA phosphatase
HKO16_03105	COG0037	tRNA processing
HKO16_03145	COG1764	response to oxidative stress
HKO16_03150	COG1846	Transcriptional regulator
HKO16_03160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKO16_03220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HKO16_03225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HKO16_03230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HKO16_03240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HKO16_03290	COG1214	PFAM Peptidase M22, glycoprotease
HKO16_03315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HKO16_03320	COG0561	phosphatase activity
HKO16_03330	COG2132	Multicopper oxidase
HKO16_03350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HKO16_03355	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HKO16_03360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HKO16_03390	COG1063	alcohol dehydrogenase
HKO16_03395	COG0583	DNA-binding transcription factor activity
HKO16_03400	COG1960	acyl-CoA dehydrogenase activity
HKO16_03405	COG2814	Major facilitator Superfamily
HKO16_03410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HKO16_03420	COG1053	succinate dehydrogenase
HKO16_03425	COG0583	DNA-binding transcription factor activity
HKO16_03440	COG0583	DNA-binding transcription factor activity
HKO16_03450	COG1473	amidohydrolase
HKO16_03470	COG0583	DNA-binding transcription factor activity
HKO16_03485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_03530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HKO16_03545	COG0745	RESPONSE REGULATOR receiver
HKO16_03550	COG2205	protein histidine kinase activity
HKO16_03585	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HKO16_03615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HKO16_03620	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HKO16_03645	COG0583	DNA-binding transcription factor activity
HKO16_03665	COG0668	transmembrane transport
HKO16_03675	COG2081	HI0933 family
HKO16_03680	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HKO16_03710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKO16_03710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HKO16_03720	COG0489	protein tyrosine kinase activity
HKO16_03770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HKO16_03780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HKO16_03795	COG0730	response to heat
HKO16_03805	COG1196	nuclear chromosome segregation
HKO16_03825	COG2223	nitrite transmembrane transporter activity
HKO16_03830	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HKO16_03835	COG1877	trehalose-phosphatase activity
HKO16_03840	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKO16_03840	COG2226	methyltransferase
HKO16_03840	COG0596	Alpha beta hydrolase
HKO16_03855	COG4106	trans-aconitate 2-methyltransferase activity
HKO16_03870	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HKO16_03875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HKO16_03880	COG0009	L-threonylcarbamoyladenylate synthase
HKO16_03885	COG3101	peptidyl-lysine hydroxylation
HKO16_03890	COG1399	metal-binding, possibly nucleic acid-binding protein
HKO16_03915	COG1652	LysM domain
HKO16_03920	COG0352	thiamine-phosphate diphosphorylase activity
HKO16_03920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKO16_03920	COG0351	phosphomethylpyrimidine kinase
HKO16_03930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HKO16_03960	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HKO16_03990	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HKO16_04005	COG0358	DNA primase activity
HKO16_04015	COG0564	pseudouridine synthase activity
HKO16_04040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKO16_04060	COG0583	DNA-binding transcription factor activity
HKO16_04065	COG0473	3-isopropylmalate dehydrogenase activity
HKO16_04085	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_04105	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HKO16_04105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HKO16_04165	COG0456	acetyltransferase
HKO16_04175	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HKO16_04180	COG0492	ferredoxin-NADP+ reductase activity
HKO16_04185	COG1674	ftsk spoiiie
HKO16_04185	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HKO16_04190	COG1280	lysine exporter protein (LysE YggA)
HKO16_04205	COG2894	cell division
HKO16_04220	COG0204	Acyl-transferase
HKO16_04225	COG2885	chlorophyll binding
HKO16_04230	COG0210	DNA helicase
HKO16_04240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKO16_04255	COG0121	glutamine amidotransferase
HKO16_04275	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKO16_04280	COG0735	belongs to the Fur family
HKO16_04305	COG0420	3'-5' exonuclease activity
HKO16_04325	COG1090	epimerase
HKO16_04340	COG2050	protein possibly involved in aromatic compounds catabolism
HKO16_04350	COG2814	Major facilitator Superfamily
HKO16_04355	COG0405	Gamma-glutamyltransferase
HKO16_04395	COG0477	Major facilitator Superfamily
HKO16_04400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKO16_04425	COG0531	amino acid
HKO16_04430	COG2040	homocysteine
HKO16_04455	COG1309	transcriptional regulator
HKO16_04460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKO16_04465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKO16_04475	COG1607	acyl-coa hydrolase
HKO16_04485	COG0523	cobalamin synthesis protein
HKO16_04495	COG4681	YaeQ
HKO16_04505	COG1649	PFAM Uncharacterised BCR, COG1649
HKO16_04505	COG0726	polysaccharide deacetylase
HKO16_04510	COG1215	transferase activity, transferring glycosyl groups
HKO16_04520	COG1024	Enoyl-CoA hydratase
HKO16_04535	COG1414	Transcriptional regulator
HKO16_04555	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_04565	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKO16_04570	COG2271	Major facilitator Superfamily
HKO16_04580	COG2267	carboxylic ester hydrolase activity
HKO16_04585	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_04600	COG0028	Belongs to the TPP enzyme family
HKO16_04610	COG0477	Major facilitator Superfamily
HKO16_04615	COG0242	peptide deformylase activity
HKO16_04620	COG2066	Belongs to the glutaminase family
HKO16_04625	COG2207	Transcriptional regulator
HKO16_04630	COG2223	nitrite transmembrane transporter activity
HKO16_04650	COG0583	DNA-binding transcription factor activity
HKO16_04655	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_04660	COG2271	Major facilitator Superfamily
HKO16_04665	COG3959	Transketolase, thiamine diphosphate binding domain
HKO16_04670	COG3958	Transketolase
HKO16_04680	COG0306	phosphate transporter
HKO16_04700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HKO16_04745	COG4181	ATPase activity
HKO16_04750	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HKO16_04780	COG0583	DNA-binding transcription factor activity
HKO16_04790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKO16_04795	COG1773	rubredoxin
HKO16_04845	COG2851	Citrate transporter
HKO16_04850	COG1253	flavin adenine dinucleotide binding
HKO16_04895	COG0804	urea catabolic process
HKO16_04905	COG0830	nickel cation binding
HKO16_04920	COG0742	ribosomal rna small subunit methyltransferase
HKO16_04925	COG0768	penicillin binding
HKO16_04950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HKO16_04955	COG2878	Part of a membrane complex involved in electron transport
HKO16_04960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKO16_04970	COG3384	dioxygenase
HKO16_04995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HKO16_05035	COG0006	proline dipeptidase activity
HKO16_05040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKO16_05045	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKO16_05065	COG1279	arginine transmembrane transporter activity
HKO16_05070	COG0583	DNA-binding transcription factor activity
HKO16_05110	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKO16_05115	COG1388	LysM domain
HKO16_05115	COG0741	lytic transglycosylase activity
HKO16_05115	COG1388	LysM domain
HKO16_05115	COG0741	lytic transglycosylase activity
HKO16_05125	COG4174	ABC transporter (Permease)
HKO16_05130	COG4239	(ABC) transporter, permease
HKO16_05135	COG4172	Belongs to the ABC transporter superfamily
HKO16_05155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HKO16_05165	COG3706	GGDEF domain
HKO16_05165	COG2203	Gaf domain
HKO16_05165	COG4251	negative regulation of phosphorylation
HKO16_05165	COG5001	Diguanylate cyclase
HKO16_05180	COG1902	pentaerythritol trinitrate reductase activity
HKO16_05180	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKO16_05215	COG0251	oxidation-reduction process
HKO16_05225	COG0583	DNA-binding transcription factor activity
HKO16_05270	COG1113	amino acid transport
HKO16_05280	COG0531	amino acid
HKO16_05300	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_05320	COG1113	amino acid transport
HKO16_05350	COG0697	spore germination
HKO16_05355	COG2721	sulfolactate sulfo-lyase activity
HKO16_05360	COG2271	Major facilitator Superfamily
HKO16_05365	COG4948	Mandelate Racemase Muconate Lactonizing
HKO16_05375	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_05380	COG2186	Transcriptional regulator
HKO16_05405	COG1960	acyl-CoA dehydrogenase activity
HKO16_05415	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_05420	COG1024	Enoyl-CoA hydratase
HKO16_05425	COG2814	Major facilitator Superfamily
HKO16_05440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKO16_05485	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HKO16_05490	COG2072	flavoprotein involved in K transport
HKO16_05495	COG0300	oxidoreductase activity
HKO16_05505	COG1309	transcriptional regulator
HKO16_05510	COG1741	Belongs to the pirin family
HKO16_05525	COG2072	flavoprotein involved in K transport
HKO16_05535	COG2252	PERMEase
HKO16_05540	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HKO16_05545	COG3038	cytochrome b561
HKO16_05555	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HKO16_05565	COG0527	aspartate kinase activity
HKO16_05615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HKO16_05620	COG4197	protein conserved in bacteria, prophage-related
HKO16_05700	COG5410	chromosome segregation
HKO16_05705	COG3567	Phage-associated protein, HI1409 family
HKO16_05725	COG3566	protein conserved in bacteria
HKO16_05860	COG0582	viral genome integration into host DNA
HKO16_05880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HKO16_05895	COG0667	Aldo Keto reductase
HKO16_05905	COG1765	OsmC-like protein
HKO16_05920	COG0542	response to heat
HKO16_05955	COG2885	chlorophyll binding
HKO16_05965	COG0625	glutathione transferase activity
HKO16_05970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HKO16_05990	COG3634	alkyl hydroperoxide reductase activity
HKO16_06000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HKO16_06010	COG0450	alkyl hydroperoxide reductase
HKO16_06015	COG1643	Atp-dependent helicase
HKO16_06030	COG2814	Major facilitator Superfamily
HKO16_06035	COG3135	benzoate transporter
HKO16_06040	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_06045	COG0543	2 iron, 2 sulfur cluster binding
HKO16_06045	COG0633	Ferredoxin
HKO16_06050	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HKO16_06055	COG4638	Rieske (2fe-2S)
HKO16_06060	COG0583	DNA-binding transcription factor activity
HKO16_06110	COG1570	exodeoxyribonuclease VII activity
HKO16_06145	COG1280	lysine exporter protein (LysE YggA)
HKO16_06150	COG1278	Cold shock
HKO16_06185	COG2814	Major facilitator Superfamily
HKO16_06225	COG0517	IMP dehydrogenase activity
HKO16_06225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HKO16_06230	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HKO16_06240	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HKO16_06245	COG1137	ATPase activity
HKO16_06255	COG1538	Outer membrane efflux protein
HKO16_06285	COG4122	O-methyltransferase activity
HKO16_06295	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HKO16_06310	COG1522	sequence-specific DNA binding
HKO16_06325	COG1560	Kdo2-lipid A biosynthetic process
HKO16_06330	COG0598	Magnesium transport protein CorA
HKO16_06345	COG2814	Major facilitator Superfamily
HKO16_06365	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKO16_06400	COG0583	DNA-binding transcription factor activity
HKO16_06405	COG1914	H( )-stimulated, divalent metal cation uptake system
HKO16_06425	COG4770	biotin carboxylase activity
HKO16_06430	COG0038	chloride channel
HKO16_06440	COG1309	transcriptional regulator
HKO16_06450	COG1063	alcohol dehydrogenase
HKO16_06465	COG0439	Biotin carboxylase
HKO16_06470	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_06475	COG1733	regulation of RNA biosynthetic process
HKO16_06490	COG0864	Transcriptional regulator
HKO16_06500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKO16_06505	COG1116	anion transmembrane transporter activity
HKO16_06530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HKO16_06635	COG0590	tRNA wobble adenosine to inosine editing
HKO16_06640	COG2807	transmembrane transport
HKO16_06655	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HKO16_06665	COG0789	Transcriptional regulator
HKO16_06675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKO16_06695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HKO16_06720	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_06725	COG0531	amino acid
HKO16_06730	COG1760	l-serine dehydratase
HKO16_06735	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_06735	COG2030	dehydratase
HKO16_06740	COG3396	Phenylacetate-CoA oxygenase
HKO16_06745	COG3460	Phenylacetate-CoA oxygenase
HKO16_06750	COG3396	Phenylacetate-CoA oxygenase
HKO16_06755	COG2151	metal-sulfur cluster biosynthetic enzyme
HKO16_06760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKO16_06765	COG1024	Enoyl-CoA hydratase
HKO16_06770	COG1024	Enoyl-CoA hydratase
HKO16_06775	COG1250	3-hydroxyacyl-CoA dehydrogenase
HKO16_06780	COG0183	Belongs to the thiolase family
HKO16_06785	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HKO16_06790	COG3327	negative regulation of DNA-templated transcription, initiation
HKO16_06800	COG2050	protein possibly involved in aromatic compounds catabolism
HKO16_06830	COG0753	catalase activity
HKO16_06835	COG3038	cytochrome b561
HKO16_06840	COG0583	DNA-binding transcription factor activity
HKO16_06850	COG1414	Transcriptional regulator
HKO16_06855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKO16_06870	COG1840	ABC-type Fe3 transport system, periplasmic component
HKO16_06875	COG3842	ATPase activity
HKO16_06890	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HKO16_06895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HKO16_06915	COG0583	DNA-binding transcription factor activity
HKO16_06925	COG4770	biotin carboxylase activity
HKO16_06930	COG1024	Enoyl-CoA hydratase
HKO16_06935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKO16_06940	COG1960	acyl-CoA dehydrogenase activity
HKO16_06945	COG1309	transcriptional regulator
HKO16_06950	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_06970	COG0583	DNA-binding transcription factor activity
HKO16_07020	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_07060	COG0784	Response regulator, receiver
HKO16_07060	COG2205	protein histidine kinase activity
HKO16_07080	COG0765	amino acid transport
HKO16_07085	COG0765	amino acid transport
HKO16_07095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKO16_07100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HKO16_07125	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HKO16_07130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKO16_07135	COG1045	serine acetyltransferase
HKO16_07150	COG0583	DNA-binding transcription factor activity
HKO16_07155	COG0625	glutathione transferase activity
HKO16_07160	COG0625	glutathione transferase activity
HKO16_07165	COG0583	DNA-binding transcription factor activity
HKO16_07175	COG1346	cytolysis
HKO16_07180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_07195	COG2814	Major facilitator Superfamily
HKO16_07205	COG0583	DNA-binding transcription factor activity
HKO16_07215	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HKO16_07220	COG3052	prosthetic group binding
HKO16_07240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HKO16_07260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_07270	COG1294	oxidase, subunit
HKO16_07275	COG1271	oxidase subunit
HKO16_07295	COG0477	Major facilitator Superfamily
HKO16_07305	COG4521	taurine ABC transporter
HKO16_07310	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HKO16_07315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKO16_07320	COG2175	clavaminate synthase activity
HKO16_07330	COG1953	Uracil, thiamine, allantoin
HKO16_07340	COG0583	DNA-binding transcription factor activity
HKO16_07350	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HKO16_07365	COG0640	Transcriptional regulator
HKO16_07370	COG0798	PFAM Bile acid sodium symporter
HKO16_07375	COG0583	DNA-binding transcription factor activity
HKO16_07390	COG3634	alkyl hydroperoxide reductase activity
HKO16_07425	COG1301	dicarboxylic acid transport
HKO16_07430	COG0436	Aminotransferase
HKO16_07440	COG0386	Belongs to the glutathione peroxidase family
HKO16_07480	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HKO16_07505	COG0012	GTP binding
HKO16_07510	COG2011	ABC-type metal ion transport system permease component
HKO16_07515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKO16_07525	COG1464	Belongs to the NlpA lipoprotein family
HKO16_07555	COG0765	amino acid transport
HKO16_07560	COG0765	amino acid transport
HKO16_07565	COG1126	abc transporter atp-binding protein
HKO16_07575	COG1522	sequence-specific DNA binding
HKO16_07590	COG1309	transcriptional regulator
HKO16_07610	COG0583	DNA-binding transcription factor activity
HKO16_07620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HKO16_07630	COG0697	spore germination
HKO16_07655	COG3121	Chaperone
HKO16_07660	COG3539	Fimbrial protein
HKO16_07685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HKO16_07685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HKO16_07730	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HKO16_07740	COG2353	YceI-like domain
HKO16_07750	COG3698	Phosphodiester glycosidase
HKO16_07765	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HKO16_07770	COG0506	proline dehydrogenase activity
HKO16_07770	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKO16_07770	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HKO16_07780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKO16_07785	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HKO16_07805	COG1132	(ABC) transporter
HKO16_07810	COG3122	Protein conserved in bacteria
HKO16_07815	COG3619	membrane
HKO16_07825	COG0640	Transcriptional regulator
HKO16_07835	COG2850	peptidyl-arginine hydroxylation
HKO16_07840	COG0424	maF-like protein
HKO16_07860	COG0191	fructose-bisphosphate aldolase activity
HKO16_07865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HKO16_07880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HKO16_07890	COG1192	Involved in chromosome partitioning
HKO16_07895	COG1475	DNA binding
HKO16_07900	COG0811	peptide transport
HKO16_07910	COG1132	(ABC) transporter
HKO16_07915	COG1663	tetraacyldisaccharide 4'-kinase activity
HKO16_07935	COG0084	hydrolase, TatD family'
HKO16_08000	COG0776	regulation of translation
HKO16_08030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HKO16_08100	COG0305	Participates in initiation and elongation during chromosome replication
HKO16_08190	COG4695	Portal protein
HKO16_08300	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HKO16_08350	COG0339	signal peptide processing
HKO16_08360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HKO16_08395	COG0702	epimerase
HKO16_08400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKO16_08420	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HKO16_08450	COG0316	Belongs to the HesB IscA family
HKO16_08455	COG0822	iron-sulfur transferase activity
HKO16_08480	COG0776	regulation of translation
HKO16_08490	COG2207	Transcriptional regulator
HKO16_08495	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKO16_08500	COG1960	acyl-CoA dehydrogenase activity
HKO16_08505	COG1960	acyl-CoA dehydrogenase activity
HKO16_08520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HKO16_08535	COG2814	Major facilitator Superfamily
HKO16_08540	COG4264	IucA IucC family
HKO16_08545	COG4264	IucA IucC family
HKO16_08555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HKO16_08600	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HKO16_08605	COG0406	alpha-ribazole phosphatase activity
HKO16_08620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HKO16_08625	COG0730	response to heat
HKO16_08645	COG4773	Receptor
HKO16_08650	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKO16_08665	COG1131	(ABC) transporter
HKO16_08670	COG0842	Transport permease protein
HKO16_08675	COG0842	Transport permease protein
HKO16_08730	COG2226	methyltransferase
HKO16_08755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HKO16_08760	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HKO16_08790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKO16_08800	COG0133	tryptophan synthase activity
HKO16_08815	COG3706	GGDEF domain
HKO16_08830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HKO16_08835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HKO16_08840	COG0022	dehydrogenase e1 component
HKO16_08845	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKO16_08850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKO16_08860	COG1063	alcohol dehydrogenase
HKO16_08865	COG3781	membrane
HKO16_08875	COG3453	Protein conserved in bacteria
HKO16_08875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKO16_08885	COG0730	response to heat
HKO16_08900	COG2207	Transcriptional regulator
HKO16_08900	COG3708	Transcriptional regulator
HKO16_08905	COG1733	regulation of RNA biosynthetic process
HKO16_08910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HKO16_08920	COG2188	Transcriptional regulator
HKO16_08935	COG4521	taurine ABC transporter
HKO16_08940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKO16_08960	COG0477	Major facilitator Superfamily
HKO16_08970	COG1027	Aspartate ammonia-lyase
HKO16_08985	COG0583	DNA-binding transcription factor activity
HKO16_08990	COG0583	DNA-binding transcription factor activity
HKO16_08995	COG0183	Belongs to the thiolase family
HKO16_09000	COG2031	fatty acid transporter
HKO16_09015	COG0583	DNA-binding transcription factor activity
HKO16_09035	COG1309	transcriptional regulator
HKO16_09045	COG2610	gluconate transmembrane transporter activity
HKO16_09050	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_09055	COG2207	Transcriptional regulator
HKO16_09070	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_09080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_09115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKO16_09120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_09125	COG0745	RESPONSE REGULATOR receiver
HKO16_09130	COG2205	protein histidine kinase activity
HKO16_09145	COG2207	Transcriptional regulator
HKO16_09195	COG2856	Zn peptidase
HKO16_09230	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HKO16_09325	COG1120	ATPase activity
HKO16_09340	COG1064	alcohol dehydrogenase
HKO16_09345	COG2207	Transcriptional regulator
HKO16_09350	COG2084	Dehydrogenase
HKO16_09360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKO16_09365	COG0583	DNA-binding transcription factor activity
HKO16_09375	COG0129	dihydroxy-acid dehydratase activity
HKO16_09380	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_09395	COG1566	PFAM secretion protein HlyD family protein
HKO16_09410	COG0583	DNA-binding transcription factor activity
HKO16_09425	COG2188	Transcriptional regulator
HKO16_09500	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_09510	COG1960	acyl-CoA dehydrogenase activity
HKO16_09520	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_09525	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_09530	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_09535	COG0583	DNA-binding transcription factor activity
HKO16_09540	COG1309	transcriptional regulator
HKO16_09565	COG0789	Transcriptional regulator
HKO16_09575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HKO16_09585	COG1902	pentaerythritol trinitrate reductase activity
HKO16_09585	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKO16_09600	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_09620	COG2186	Transcriptional regulator
HKO16_09630	COG0583	DNA-binding transcription factor activity
HKO16_09635	COG4948	Mandelate Racemase Muconate Lactonizing
HKO16_09640	COG4829	muconolactone delta-isomerase
HKO16_09650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HKO16_09655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HKO16_09660	COG0183	Belongs to the thiolase family
HKO16_09665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HKO16_09675	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_09685	COG3733	amine oxidase
HKO16_09695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_09705	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_09715	COG4638	Rieske (2fe-2S)
HKO16_09735	COG0154	amidase activity
HKO16_09745	COG2814	Major facilitator Superfamily
HKO16_09770	COG1960	acyl-CoA dehydrogenase activity
HKO16_09775	COG0583	DNA-binding transcription factor activity
HKO16_09780	COG1414	Transcriptional regulator
HKO16_09795	COG2391	methyltransferase activity
HKO16_09805	COG4993	Dehydrogenase
HKO16_09810	COG3659	wide pore channel activity
HKO16_09815	COG3420	alginic acid biosynthetic process
HKO16_09820	COG0710	3-dehydroquinate dehydratase activity
HKO16_09825	COG3485	protocatechuate 3,4-dioxygenase
HKO16_09830	COG3485	protocatechuate 3,4-dioxygenase
HKO16_09835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HKO16_09840	COG2271	Major facilitator Superfamily
HKO16_09845	COG0596	Alpha beta hydrolase
HKO16_09850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HKO16_09855	COG0183	Belongs to the thiolase family
HKO16_09860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HKO16_09865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HKO16_09875	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HKO16_09880	COG2323	membrane
HKO16_09925	COG1902	pentaerythritol trinitrate reductase activity
HKO16_09925	COG0446	pyridine nucleotide-disulphide oxidoreductase
HKO16_09950	COG0542	response to heat
HKO16_09955	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HKO16_09985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKO16_09990	COG0569	domain protein
HKO16_09995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HKO16_10010	COG4774	siderophore transport
HKO16_10015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HKO16_10025	COG1585	Membrane protein implicated in regulation of membrane protease activity
HKO16_10040	COG1294	oxidase, subunit
HKO16_10045	COG4890	Cyd operon protein YbgT
HKO16_10060	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HKO16_10070	COG0552	protein localization to endoplasmic reticulum
HKO16_10095	COG0516	GMP reductase activity
HKO16_10095	COG0517	IMP dehydrogenase activity
HKO16_10100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKO16_10105	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HKO16_10115	COG0583	DNA-binding transcription factor activity
HKO16_10120	COG0024	Methionine aminopeptidase
HKO16_10150	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HKO16_10150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HKO16_10155	COG1105	Belongs to the carbohydrate kinase PfkB family
HKO16_10160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKO16_10160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HKO16_10160	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HKO16_10175	COG3300	MHYT domain
HKO16_10175	COG5001	Diguanylate cyclase
HKO16_10190	COG2135	peptidase activity
HKO16_10195	COG0659	secondary active sulfate transmembrane transporter activity
HKO16_10210	COG1113	amino acid transport
HKO16_10220	COG1522	sequence-specific DNA binding
HKO16_10245	COG1011	Hydrolase
HKO16_10250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HKO16_10260	COG2137	regulation of response to DNA damage stimulus
HKO16_10275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HKO16_10295	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HKO16_10310	COG0575	Belongs to the CDS family
HKO16_10315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HKO16_10340	COG3852	Histidine kinase
HKO16_10345	COG2204	response regulator
HKO16_10400	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKO16_10405	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HKO16_10425	COG0697	spore germination
HKO16_10430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_10440	COG0303	'Molybdopterin
HKO16_10445	COG0315	cyclic pyranopterin monophosphate synthase activity
HKO16_10445	COG0521	Mo-molybdopterin cofactor biosynthetic process
HKO16_10460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HKO16_10465	COG0243	molybdopterin cofactor binding
HKO16_10475	COG0243	molybdopterin cofactor binding
HKO16_10480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKO16_10485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKO16_10485	COG2146	nitrite reductase [NAD(P)H] activity
HKO16_10495	COG0745	RESPONSE REGULATOR receiver
HKO16_10500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKO16_10500	COG1116	anion transmembrane transporter activity
HKO16_10520	COG0511	ligase activity, forming carbon-carbon bonds
HKO16_10535	COG2814	Major facilitator Superfamily
HKO16_10550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKO16_10620	COG1598	PFAM Uncharacterised protein family UPF0150
HKO16_10725	COG5410	chromosome segregation
HKO16_10765	COG3617	BRO family, N-terminal domain
HKO16_10910	COG0069	glutamate synthase activity
HKO16_10930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HKO16_10940	COG1454	alcohol dehydrogenase
HKO16_10945	COG0824	Thioesterase
HKO16_10955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HKO16_10975	COG2030	dehydratase
HKO16_10985	COG0183	Belongs to the thiolase family
HKO16_10995	COG0583	DNA-binding transcription factor activity
HKO16_11000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HKO16_11010	COG1522	sequence-specific DNA binding
HKO16_11015	COG3135	benzoate transporter
HKO16_11025	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HKO16_11050	COG0589	response to stress
HKO16_11055	COG0488	(ABC) transporter
HKO16_11075	COG4773	Receptor
HKO16_11105	COG0668	transmembrane transport
HKO16_11115	COG1309	transcriptional regulator
HKO16_11130	COG1605	Chorismate mutase
HKO16_11170	COG0308	aminopeptidase N
HKO16_11195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HKO16_11200	COG1454	alcohol dehydrogenase
HKO16_11220	COG0531	amino acid
HKO16_11225	COG4303	Ethanolamine ammonia lyase large subunit
HKO16_11230	COG4302	ethanolamine ammonia-lyase activity
HKO16_11235	COG0519	Catalyzes the synthesis of GMP from XMP
HKO16_11235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKO16_11240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HKO16_11265	COG0697	spore germination
HKO16_11270	COG1923	regulation of RNA biosynthetic process
HKO16_11280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HKO16_11285	COG0802	atpase or kinase
HKO16_11305	COG1187	pseudouridine synthase activity
HKO16_11320	COG0583	DNA-binding transcription factor activity
HKO16_11335	COG2814	Major facilitator Superfamily
HKO16_11340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HKO16_11365	COG0729	surface antigen
HKO16_11385	COG0174	glutamine synthetase
HKO16_11390	COG0745	RESPONSE REGULATOR receiver
HKO16_11395	COG2205	protein histidine kinase activity
HKO16_11400	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HKO16_11405	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HKO16_11410	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HKO16_11420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HKO16_11435	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_11440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKO16_11445	COG1960	acyl-CoA dehydrogenase activity
HKO16_11475	COG0583	DNA-binding transcription factor activity
HKO16_11490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKO16_11500	COG3658	cytochrome
HKO16_11505	COG1215	transferase activity, transferring glycosyl groups
HKO16_11510	COG1649	PFAM Uncharacterised BCR, COG1649
HKO16_11510	COG0726	polysaccharide deacetylase
HKO16_11535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HKO16_11540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HKO16_11550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HKO16_11575	COG0305	Participates in initiation and elongation during chromosome replication
HKO16_11580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HKO16_11590	COG1305	Transglutaminase-like
HKO16_11600	COG2308	Evidence 4 Homologs of previously reported genes of
HKO16_11630	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HKO16_11635	COG0138	bifunctional purine biosynthesis protein purh
HKO16_11640	COG0151	Belongs to the GarS family
HKO16_11645	COG1464	Belongs to the NlpA lipoprotein family
HKO16_11650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HKO16_11655	COG2011	ABC-type metal ion transport system permease component
HKO16_11660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKO16_11670	COG1301	dicarboxylic acid transport
HKO16_11700	COG1794	racemase activity, acting on amino acids and derivatives
HKO16_11715	COG3008	intermembrane lipid transfer
HKO16_11715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HKO16_11720	COG2995	paraquat-inducible protein a
HKO16_11750	COG1051	belongs to the nudix hydrolase family
HKO16_11755	COG0477	Major facilitator Superfamily
HKO16_11805	COG2186	Transcriptional regulator
HKO16_11815	COG0786	glutamate:sodium symporter activity
HKO16_11820	COG3243	poly(R)-hydroxyalkanoic acid synthase
HKO16_11845	COG3111	PFAM Bacterial OB fold (BOF) protein
HKO16_11915	COG0515	serine threonine protein kinase
HKO16_11915	COG2815	serine threonine protein kinase
HKO16_11945	COG1610	YqeY-like protein
HKO16_11950	COG4783	chaperone-mediated protein folding
HKO16_11975	COG1286	toxin biosynthetic process
HKO16_12005	COG0778	Nitroreductase
HKO16_12015	COG0513	Belongs to the DEAD box helicase family
HKO16_12035	COG2363	Small membrane protein
HKO16_12065	COG4650	regulator
HKO16_12070	COG1234	tRNA 3'-trailer cleavage
HKO16_12075	COG1690	Belongs to the RtcB family
HKO16_12095	COG2195	Cleaves the N-terminal amino acid of tripeptides
HKO16_12105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HKO16_12115	COG2819	hydrolase of the alpha beta superfamily
HKO16_12120	COG1960	acyl-CoA dehydrogenase activity
HKO16_12125	COG1301	dicarboxylic acid transport
HKO16_12130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HKO16_12135	COG3139	Protein of unknown function (DUF1315)
HKO16_12140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HKO16_12145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HKO16_12155	COG0494	nUDIX hydrolase
HKO16_12165	COG0642	Histidine kinase
HKO16_12170	COG0745	RESPONSE REGULATOR receiver
HKO16_12190	COG1720	tRNA m6t6A37 methyltransferase activity
HKO16_12205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_12215	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HKO16_12225	COG4598	ABC transporter
HKO16_12230	COG4160	amino acid transport
HKO16_12235	COG4215	(ABC) transporter
HKO16_12250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_12295	COG1131	(ABC) transporter
HKO16_12300	COG0842	Transport permease protein
HKO16_12315	COG0772	Belongs to the SEDS family
HKO16_12320	COG2951	lytic endotransglycosylase activity
HKO16_12345	COG2207	Transcriptional regulator
HKO16_12360	COG0052	Belongs to the universal ribosomal protein uS2 family
HKO16_12365	COG0024	Methionine aminopeptidase
HKO16_12375	COG2223	nitrite transmembrane transporter activity
HKO16_12385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKO16_12390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HKO16_12395	COG1960	acyl-CoA dehydrogenase activity
HKO16_12410	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HKO16_12415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HKO16_12420	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HKO16_12440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKO16_12445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HKO16_12450	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HKO16_12485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HKO16_12495	COG0174	glutamine synthetase
HKO16_12500	COG3104	oligopeptide transport
HKO16_12510	COG0512	Glutamine amidotransferase of anthranilate synthase
HKO16_12515	COG0308	aminopeptidase N
HKO16_12545	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HKO16_12575	COG3739	integral membrane protein
HKO16_12600	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HKO16_12610	COG1132	(ABC) transporter
HKO16_12625	COG1535	isochorismatase
HKO16_12625	COG3433	isochorismatase activity
HKO16_12630	COG1021	2,3-dihydroxybenzoate-AMP ligase
HKO16_12635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_12645	COG4774	siderophore transport
HKO16_12650	COG4607	ABC-type enterochelin transport system periplasmic component
HKO16_12655	COG4604	ABC transporter, ATP-binding protein
HKO16_12660	COG4605	iron ion homeostasis
HKO16_12665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HKO16_12670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_12685	COG2964	Protein conserved in bacteria
HKO16_12695	COG1741	Belongs to the pirin family
HKO16_12735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HKO16_12745	COG0596	Alpha beta hydrolase
HKO16_12760	COG0583	DNA-binding transcription factor activity
HKO16_12765	COG1335	isochorismatase
HKO16_12805	COG2879	small protein
HKO16_12810	COG1966	Carbon starvation protein
HKO16_12830	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HKO16_12855	COG1067	ATP-dependent peptidase activity
HKO16_12860	COG0583	DNA-binding transcription factor activity
HKO16_12885	COG1686	Belongs to the peptidase S11 family
HKO16_12890	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HKO16_12925	COG0616	signal peptide processing
HKO16_12930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HKO16_12940	COG0573	inorganic phosphate transmembrane transporter activity
HKO16_12945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HKO16_12950	COG1113	amino acid transport
HKO16_12955	COG3961	Belongs to the TPP enzyme family
HKO16_12960	COG1522	sequence-specific DNA binding
HKO16_12970	COG0076	glutamate decarboxylase activity
HKO16_12975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKO16_12990	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_13000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKO16_13035	COG0352	thiamine-phosphate diphosphorylase activity
HKO16_13060	COG0612	Peptidase, M16
HKO16_13075	COG0583	DNA-binding transcription factor activity
HKO16_13080	COG0477	Major facilitator Superfamily
HKO16_13105	COG1187	pseudouridine synthase activity
HKO16_13120	COG1686	Belongs to the peptidase S11 family
HKO16_13125	COG1252	NADH dehydrogenase
HKO16_13135	COG0415	Belongs to the DNA photolyase family
HKO16_13150	COG1215	transferase activity, transferring glycosyl groups
HKO16_13180	COG2070	2-Nitropropane dioxygenase
HKO16_13235	COG0556	nucleotide-excision repair
HKO16_13255	COG0436	Aminotransferase
HKO16_13265	COG0443	Heat shock 70 kDa protein
HKO16_13295	COG4221	oxidoreductase activity
HKO16_13305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HKO16_13310	COG1381	Involved in DNA repair and RecF pathway recombination
HKO16_13320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HKO16_13335	COG0681	Belongs to the peptidase S26 family
HKO16_13345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HKO16_13355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HKO16_13375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HKO16_13380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HKO16_13385	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HKO16_13395	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HKO16_13400	COG4208	sulfate ABC transporter
HKO16_13405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HKO16_13410	COG0583	DNA-binding transcription factor activity
HKO16_13415	COG4625	pathogenesis
HKO16_13430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HKO16_13445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HKO16_13455	COG1056	cytidyltransferase-related domain
HKO16_13455	COG1051	belongs to the nudix hydrolase family
HKO16_13460	COG1024	Enoyl-CoA hydratase
HKO16_13530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_13540	COG0534	Mate efflux family protein
HKO16_13555	COG4774	siderophore transport
HKO16_13560	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HKO16_13580	COG0019	diaminopimelate decarboxylase activity
HKO16_13585	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HKO16_13590	COG1021	2,3-dihydroxybenzoate-AMP ligase
HKO16_13595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_13600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_13600	COG3433	isochorismatase activity
HKO16_13600	COG2226	methyltransferase
HKO16_13605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_13610	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_13615	COG1535	isochorismatase
HKO16_13615	COG3433	isochorismatase activity
HKO16_13620	COG1169	isochorismate synthase
HKO16_13645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HKO16_13645	COG0047	phosphoribosylformylglycinamidine synthase activity
HKO16_13665	COG1473	amidohydrolase
HKO16_13670	COG0824	Thioesterase
HKO16_13690	COG0823	Involved in the tonB-independent uptake of proteins
HKO16_13710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HKO16_13745	COG0628	permease
HKO16_13755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HKO16_13760	COG0596	Alpha beta hydrolase
HKO16_13765	COG0616	signal peptide processing
HKO16_13765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HKO16_13775	COG0658	competence protein
HKO16_13775	COG2333	competence protein COMEC
HKO16_13780	COG1136	(ABC) transporter
HKO16_13785	COG4591	ABC-type transport system involved in lipoprotein release permease component
HKO16_13820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_13840	COG0463	Glycosyl transferase, family 2
HKO16_13870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKO16_13875	COG1280	lysine exporter protein (LysE YggA)
HKO16_13885	COG0019	diaminopimelate decarboxylase activity
HKO16_13895	COG1113	amino acid transport
HKO16_13910	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HKO16_13920	COG3339	Conserved Protein
HKO16_13925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HKO16_13930	COG0243	molybdopterin cofactor binding
HKO16_13935	COG1929	Belongs to the glycerate kinase type-1 family
HKO16_13950	COG0778	Nitroreductase
HKO16_14005	COG3811	Belongs to the UPF0386 family
HKO16_14015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_14030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKO16_14050	COG0741	lytic transglycosylase activity
HKO16_14070	COG0584	glycerophosphoryl diester phosphodiesterase
HKO16_14075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HKO16_14095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HKO16_14100	COG1597	lipid kinase activity
HKO16_14115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HKO16_14120	COG0477	Major facilitator Superfamily
HKO16_14170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HKO16_14175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HKO16_14200	COG0505	Belongs to the CarA family
HKO16_14215	COG1309	transcriptional regulator
HKO16_14220	COG0251	oxidation-reduction process
HKO16_14230	COG0589	response to stress
HKO16_14245	COG2843	Capsule synthesis protein
HKO16_14265	COG2321	neutral zinc metallopeptidase
HKO16_14270	COG2354	Protein conserved in bacteria
HKO16_14290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HKO16_14315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HKO16_14320	COG1053	succinate dehydrogenase
HKO16_14325	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HKO16_14330	COG2009	succinate dehydrogenase
HKO16_14370	COG2921	Belongs to the UPF0250 family
HKO16_14375	COG0321	lipoyl(octanoyl) transferase activity
HKO16_14390	COG0531	amino acid
HKO16_14400	COG1733	regulation of RNA biosynthetic process
HKO16_14405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HKO16_14410	COG1648	precorrin-2 dehydrogenase activity
HKO16_14410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HKO16_14425	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HKO16_14455	COG0671	phosphoesterase, PA-phosphatase related
HKO16_14460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HKO16_14470	COG1538	Outer membrane efflux protein
HKO16_14475	COG0393	Putative heavy-metal-binding
HKO16_14480	COG0393	Putative heavy-metal-binding
HKO16_14490	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_14500	COG0525	valine-tRNA ligase activity
HKO16_14520	COG0583	DNA-binding transcription factor activity
HKO16_14525	COG0004	ammonium transporteR
HKO16_14535	COG0642	Histidine kinase
HKO16_14540	COG0745	RESPONSE REGULATOR receiver
HKO16_14545	COG2194	sulfuric ester hydrolase activity
HKO16_14565	COG1752	Esterase of the alpha-beta hydrolase superfamily
HKO16_14580	COG2315	Protein conserved in bacteria
HKO16_14585	COG0142	geranyltranstransferase activity
HKO16_14590	COG2828	Protein conserved in bacteria
HKO16_14595	COG1113	amino acid transport
HKO16_14615	COG2207	Transcriptional regulator
HKO16_14640	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_14650	COG0560	Phosphoserine phosphatase
HKO16_14660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HKO16_14670	COG1530	ribonuclease E activity
HKO16_14675	COG0424	maF-like protein
HKO16_14680	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HKO16_14685	COG1792	Involved in formation and maintenance of cell shape
HKO16_14690	COG1077	Cell shape determining protein MreB Mrl
HKO16_14695	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKO16_14705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HKO16_14730	COG3590	peptidase
HKO16_14735	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HKO16_14740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HKO16_14745	COG1752	Esterase of the alpha-beta hydrolase superfamily
HKO16_14750	COG1115	amino acid carrier protein
HKO16_14770	COG2814	Major facilitator Superfamily
HKO16_14775	COG1289	transmembrane transporter activity
HKO16_14785	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HKO16_14825	COG1376	ErfK ybiS ycfS ynhG family protein
HKO16_14830	COG2832	Protein of unknown function (DUF454)
HKO16_14840	COG5510	response to toxic substance
HKO16_14860	COG0840	transmembrane signaling receptor activity
HKO16_14900	COG3422	double-strand break repair
HKO16_14905	COG2824	Alkylphosphonate utilization operon protein PhnA
HKO16_14910	COG3189	MarR family transcriptional regulator
HKO16_14920	COG0354	folic acid binding
HKO16_14925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKO16_14935	COG0679	Auxin Efflux Carrier
HKO16_14940	COG1902	pentaerythritol trinitrate reductase activity
HKO16_14945	COG4772	TonB-dependent receptor
HKO16_14950	COG2094	Belongs to the DNA glycosylase MPG family
HKO16_14980	COG2233	PERMEase
HKO16_14990	COG0833	amino acid
HKO16_14995	COG1690	Belongs to the RtcB family
HKO16_15015	COG0183	Belongs to the thiolase family
HKO16_15035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HKO16_15055	COG2207	Transcriptional regulator
HKO16_15060	COG0183	Belongs to the thiolase family
HKO16_15080	COG2153	protein acetylation
HKO16_15090	COG1272	protein, Hemolysin III
HKO16_15095	COG0477	Major facilitator Superfamily
HKO16_15110	COG0450	alkyl hydroperoxide reductase
HKO16_15130	COG0285	dihydrofolate synthase activity
HKO16_15175	COG4206	TonB-dependent receptor
HKO16_15180	COG2096	Adenosyltransferase
HKO16_15200	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HKO16_15205	COG0745	RESPONSE REGULATOR receiver
HKO16_15210	COG2205	protein histidine kinase activity
HKO16_15220	COG1960	acyl-CoA dehydrogenase activity
HKO16_15225	COG1960	acyl-CoA dehydrogenase activity
HKO16_15275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HKO16_15290	COG0438	transferase activity, transferring glycosyl groups
HKO16_15295	COG0463	Glycosyl transferase, family 2
HKO16_15300	COG0726	polysaccharide deacetylase
HKO16_15320	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HKO16_15325	COG2205	protein histidine kinase activity
HKO16_15340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HKO16_15365	COG0582	viral genome integration into host DNA
HKO16_15395	COG1862	Preprotein translocase
HKO16_15405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HKO16_15410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HKO16_15420	COG3781	membrane
HKO16_15425	COG0613	PHP domain protein
HKO16_15435	COG2350	Protein conserved in bacteria
HKO16_15460	COG0582	viral genome integration into host DNA
HKO16_15510	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HKO16_15535	COG2132	Multicopper oxidase
HKO16_15550	COG2205	protein histidine kinase activity
HKO16_15635	COG3013	Belongs to the UPF0304 family
HKO16_15670	COG1607	acyl-coa hydrolase
HKO16_15730	COG2199	diguanylate cyclase activity
HKO16_15740	COG1408	metallophosphoesterase
HKO16_15745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HKO16_15755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HKO16_15775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HKO16_15780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HKO16_15785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HKO16_15795	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HKO16_15805	COG2969	positive regulation of protein catabolic process
HKO16_15825	COG1960	acyl-CoA dehydrogenase activity
HKO16_15830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HKO16_15845	COG1309	transcriptional regulator
HKO16_15850	COG1960	acyl-CoA dehydrogenase activity
HKO16_15895	COG1183	phosphatidylcholine synthase activity
HKO16_15900	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HKO16_15930	COG0741	lytic transglycosylase activity
HKO16_15930	COG1196	nuclear chromosome segregation
HKO16_15930	COG0739	heme binding
HKO16_15940	COG1702	phosphate starvation-inducible protein PhoH
HKO16_15975	COG1295	ribonuclease BN
HKO16_15980	COG0697	spore germination
HKO16_15985	COG2169	Transcriptional regulator
HKO16_15990	COG0179	Fumarylacetoacetate (FAA) hydrolase
HKO16_16035	COG0557	exoribonuclease II activity
HKO16_16040	COG0339	signal peptide processing
HKO16_16045	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HKO16_16075	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HKO16_16080	COG1960	acyl-CoA dehydrogenase activity
HKO16_16235	COG0626	cystathionine gamma-synthase activity
HKO16_16240	COG0433	COG0433 Predicted ATPase
HKO16_16250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HKO16_16250	COG1017	nitric oxide dioxygenase activity
HKO16_16255	COG1959	2 iron, 2 sulfur cluster binding
HKO16_16270	COG1301	dicarboxylic acid transport
HKO16_16275	COG1946	Acyl-CoA thioesterase
HKO16_16295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HKO16_16300	COG1040	competence protein
HKO16_16305	COG0494	nUDIX hydrolase
HKO16_16315	COG0598	Magnesium transport protein CorA
HKO16_16325	COG2854	intermembrane phospholipid transfer
HKO16_16335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HKO16_16340	COG1127	ABC transporter
HKO16_16350	COG0513	Belongs to the DEAD box helicase family
HKO16_16370	COG0408	coproporphyrinogen oxidase activity
HKO16_16385	COG1960	acyl-CoA dehydrogenase activity
HKO16_16395	COG1983	PspC domain protein
HKO16_16400	COG0517	IMP dehydrogenase activity
HKO16_16450	COG0583	DNA-binding transcription factor activity
HKO16_16490	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_16500	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HKO16_16505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HKO16_16510	COG0833	amino acid
HKO16_16540	COG1192	Involved in chromosome partitioning
HKO16_16545	COG0628	permease
HKO16_16555	COG1289	transmembrane transporter activity
HKO16_16570	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_16575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HKO16_16585	COG0277	FAD linked oxidase domain protein
HKO16_16590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HKO16_16615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HKO16_16620	COG5380	lipid catabolic process
HKO16_16640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HKO16_16690	COG0194	GDP metabolic process
HKO16_16705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HKO16_16725	COG3307	-O-antigen
HKO16_16730	COG4969	Belongs to the N-Me-Phe pilin family
HKO16_16740	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HKO16_16745	COG1704	LemA family
HKO16_16755	COG0493	'glutamate synthase
HKO16_16760	COG0067	glutamate synthase
HKO16_16760	COG0070	glutamate synthase
HKO16_16760	COG0069	glutamate synthase activity
HKO16_16810	COG2226	methyltransferase
HKO16_16825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HKO16_16830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HKO16_16875	COG0833	amino acid
HKO16_16940	COG0488	(ABC) transporter
HKO16_16965	COG4221	oxidoreductase activity
HKO16_16970	COG0659	secondary active sulfate transmembrane transporter activity
HKO16_16980	COG0745	RESPONSE REGULATOR receiver
HKO16_16995	COG0427	acetyl-CoA hydrolase
HKO16_17025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HKO16_17055	COG2329	Antibiotic biosynthesis monooxygenase
HKO16_17070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HKO16_17125	COG2207	Transcriptional regulator
HKO16_17130	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HKO16_17150	COG2249	NAD(P)H dehydrogenase (quinone) activity
HKO16_17155	COG1733	regulation of RNA biosynthetic process
HKO16_17185	COG1733	regulation of RNA biosynthetic process
HKO16_17230	COG0583	DNA-binding transcription factor activity
HKO16_17235	COG2814	Major facilitator Superfamily
HKO16_17275	COG1335	isochorismatase
HKO16_17285	COG1012	belongs to the aldehyde dehydrogenase family
HKO16_17290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HKO16_17300	COG1113	amino acid transport
HKO16_17310	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HKO16_17325	COG2814	Major facilitator Superfamily
HKO16_17335	COG0352	thiamine-phosphate diphosphorylase activity
HKO16_17335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HKO16_17335	COG0351	phosphomethylpyrimidine kinase
HKO16_17355	COG1309	transcriptional regulator
HKO16_17360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HKO16_17365	COG3706	GGDEF domain
HKO16_17375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HKO16_17385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HKO16_17390	COG3162	membrane
HKO16_17395	COG0784	Response regulator, receiver
HKO16_17395	COG2205	protein histidine kinase activity
HKO16_17395	COG2198	Histidine kinase
HKO16_17420	COG1522	sequence-specific DNA binding
HKO16_17425	COG1335	isochorismatase
HKO16_17430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKO16_17440	COG0668	transmembrane transport
HKO16_17450	COG1519	Transferase
HKO16_17455	COG1902	pentaerythritol trinitrate reductase activity
HKO16_17475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HKO16_17500	COG0426	domain, Protein
HKO16_17500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HKO16_17505	COG4774	siderophore transport
HKO16_17510	COG2119	membrane
HKO16_17520	COG0508	dehydrogenase complex catalyzes the overall conversion of
HKO16_17530	COG4942	peptidase
HKO16_17545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HKO16_17555	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HKO16_17575	COG0189	ligase activity
HKO16_17600	COG0708	Exodeoxyribonuclease III
HKO16_17605	COG1393	Belongs to the ArsC family
HKO16_17620	COG3706	GGDEF domain
HKO16_17655	COG2351	hydroxyisourate hydrolase activity
HKO16_17660	COG2233	PERMEase
HKO16_17670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HKO16_17680	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HKO16_17690	COG3150	esterase
HKO16_17725	COG1388	LysM domain
HKO16_17725	COG1705	Flagellar rod assembly protein muramidase FlgJ
HKO16_17770	COG4691	Plasmid stability protein
HKO16_17805	COG0798	PFAM Bile acid sodium symporter
HKO16_17845	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKO16_17895	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HKO16_17925	COG0659	secondary active sulfate transmembrane transporter activity
HKO16_17930	COG0589	response to stress
HKO16_17980	COG0606	chelatase, subunit chli
HKO16_17985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HKO16_17995	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HKO16_18010	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HKO16_18025	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_18035	COG0477	Major facilitator Superfamily
HKO16_18040	COG2860	membrane
HKO16_18045	COG3012	SEC-C Motif Domain Protein
HKO16_18050	COG1253	flavin adenine dinucleotide binding
HKO16_18060	COG0477	Major facilitator Superfamily
HKO16_18070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HKO16_18105	COG0655	NAD(P)H dehydrogenase (quinone) activity
HKO16_18115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HKO16_18150	COG1309	transcriptional regulator
HKO16_18185	COG0758	DNA mediated transformation
HKO16_18195	COG0697	spore germination
HKO16_18200	COG1309	transcriptional regulator
HKO16_18215	COG0386	Belongs to the glutathione peroxidase family
HKO16_18285	COG1121	(ABC) transporter
HKO16_18290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HKO16_18295	COG1280	lysine exporter protein (LysE YggA)
HKO16_18300	COG2837	iron assimilation
HKO16_18305	COG0281	malic enzyme
HKO16_18350	COG0519	Catalyzes the synthesis of GMP from XMP
HKO16_18350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HKO16_18355	COG4399	Belongs to the UPF0754 family
HKO16_18360	COG2259	Doxx family
HKO16_18365	COG0586	Pfam SNARE associated Golgi protein
HKO16_18380	COG1192	Involved in chromosome partitioning
HKO16_18390	COG0271	Belongs to the BolA IbaG family
HKO16_18430	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HKO16_18430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HKO16_18430	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HKO16_18430	COG3321	synthase
HKO16_18435	COG1960	acyl-CoA dehydrogenase activity
HKO16_18440	COG0318	PFAM AMP-dependent synthetase and ligase
HKO16_18445	COG2197	response regulator
HKO16_18455	COG3916	Acyl-homoserine-lactone synthase
HKO16_18460	COG0477	Major facilitator Superfamily
HKO16_18465	COG1024	Enoyl-CoA hydratase
HKO16_18470	COG1024	Enoyl-CoA hydratase
HKO16_18475	COG1960	acyl-CoA dehydrogenase activity
HKO16_18480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HKO16_18500	COG1113	amino acid transport
HKO16_18505	COG1113	amino acid transport
HKO16_18510	COG0251	oxidation-reduction process
HKO16_18550	COG0564	pseudouridine synthase activity
HKO16_18630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HKO16_18645	COG1802	Transcriptional regulator
HKO16_18655	COG1448	Aminotransferase
HKO16_18660	COG0277	FAD linked oxidase domain protein
HKO16_18670	COG2186	Transcriptional regulator
HKO16_18680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HKO16_18685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HKO16_18700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HKO16_18705	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HKO16_18730	COG0438	transferase activity, transferring glycosyl groups
HKO16_18760	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HKO16_18790	COG0728	peptidoglycan biosynthetic process
HKO16_18795	COG3023	N-Acetylmuramoyl-L-alanine amidase
HKO16_18855	COG0546	phosphoglycolate phosphatase activity
HKO16_18860	COG1028	Short-chain dehydrogenase reductase Sdr
HKO16_18880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKO16_18885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HKO16_18890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HKO16_18895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HKO16_18900	COG1116	anion transmembrane transporter activity
HKO16_18905	COG1309	transcriptional regulator
HKO16_18910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HKO16_18920	COG0196	riboflavin kinase activity
HKO16_18925	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HKO16_18935	COG1047	Peptidyl-prolyl cis-trans
HKO16_18975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HKO16_19030	COG2951	lytic endotransglycosylase activity
HKO16_19035	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HKO16_19050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HKO16_19060	COG0671	phosphoesterase, PA-phosphatase related
HKO16_19065	COG0861	Integral membrane protein TerC family
HKO16_19075	COG0754	glutathionylspermidine amidase activity
HKO16_19085	COG0402	S-adenosylhomocysteine deaminase activity
HKO16_19100	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HKO16_19105	COG1230	cation diffusion facilitator family transporter
HKO16_19120	COG0706	membrane insertase activity
HKO16_19150	COG0583	DNA-binding transcription factor activity
HKO16_19185	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HKO16_19245	COG3077	Addiction module antitoxin, RelB DinJ family
HKO16_19260	COG1028	Short-chain dehydrogenase reductase Sdr