locus-tag	class	description
A1S_0002	COG0592	DNA-directed DNA polymerase activity
A1S_0004	COG0187	DNA topoisomerase II activity
A1S_0006	COG0586	Pfam SNARE associated Golgi protein
A1S_0007	COG0488	(ABC) transporter
A1S_0012	COG0596	Alpha beta hydrolase
A1S_0013	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A1S_0014	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A1S_0016	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A1S_0018	COG1047	Peptidyl-prolyl cis-trans
A1S_0020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A1S_0024	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A1S_0025	COG1309	transcriptional regulator
A1S_0026	COG1116	anion transmembrane transporter activity
A1S_0027	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A1S_0028	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A1S_0029	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A1S_0030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A1S_0034	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_0035	COG0546	phosphoglycolate phosphatase activity
A1S_0045	COG3023	N-Acetylmuramoyl-L-alanine amidase
A1S_0046	COG0728	peptidoglycan biosynthetic process
A1S_0052	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A1S_0058	COG0438	transferase activity, transferring glycosyl groups
A1S_0061	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A1S_0062	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A1S_0065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A1S_0066	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1S_0068	COG2186	Transcriptional regulator
A1S_0070	COG0277	FAD linked oxidase domain protein
A1S_0071	COG1448	Aminotransferase
A1S_0072	COG1802	Transcriptional regulator
A1S_0076	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A1S_0089	COG0564	pseudouridine synthase activity
A1S_0094	COG1522	sequence-specific DNA binding
A1S_0097	COG0251	oxidation-reduction process
A1S_0098	COG1113	amino acid transport
A1S_0099	COG1113	amino acid transport
A1S_0104	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A1S_0105	COG1960	acyl-CoA dehydrogenase activity
A1S_0106	COG1024	Enoyl-CoA hydratase
A1S_0107	COG1024	Enoyl-CoA hydratase
A1S_0108	COG0477	Major facilitator Superfamily
A1S_0109	COG3916	Acyl-homoserine-lactone synthase
A1S_0111	COG2197	response regulator
A1S_0112	COG0318	PFAM AMP-dependent synthetase and ligase
A1S_0113	COG1960	acyl-CoA dehydrogenase activity
A1S_0114	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A1S_0114	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
A1S_0114	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1S_0114	COG3321	synthase
A1S_0122	COG0271	Belongs to the BolA IbaG family
A1S_0124	COG1192	Involved in chromosome partitioning
A1S_0127	COG0586	Pfam SNARE associated Golgi protein
A1S_0128	COG2259	Doxx family
A1S_0129	COG4399	Belongs to the UPF0754 family
A1S_0130	COG0519	Catalyzes the synthesis of GMP from XMP
A1S_0130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A1S_0140	COG0281	malic enzyme
A1S_0141	COG2837	iron assimilation
A1S_0143	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A1S_0144	COG1121	(ABC) transporter
A1S_0159	COG0386	Belongs to the glutathione peroxidase family
A1S_0162	COG1309	transcriptional regulator
A1S_0163	COG0697	spore germination
A1S_0166	COG0758	DNA mediated transformation
A1S_0173	COG1309	transcriptional regulator
A1S_0177	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A1S_0179	COG0655	NAD(P)H dehydrogenase (quinone) activity
A1S_0186	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A1S_0188	COG2814	Major facilitator Superfamily
A1S_0190	COG1253	flavin adenine dinucleotide binding
A1S_0191	COG3012	SEC-C Motif Domain Protein
A1S_0192	COG2860	membrane
A1S_0193	COG0477	Major facilitator Superfamily
A1S_0200	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A1S_0203	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A1S_0205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1S_0214	COG0589	response to stress
A1S_0215	COG0659	secondary active sulfate transmembrane transporter activity
A1S_0218	COG0347	Belongs to the P(II) protein family
A1S_0219	COG0004	ammonium transporteR
A1S_0221	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A1S_0221	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A1S_0229	COG0795	lipopolysaccharide-transporting ATPase activity
A1S_0230	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A1S_0231	COG0793	Belongs to the peptidase S41A family
A1S_0236	COG2197	response regulator
A1S_0238	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A1S_0240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A1S_0241	COG4974	Belongs to the 'phage' integrase family
A1S_0246	COG0772	Belongs to the SEDS family
A1S_0247	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A1S_0248	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A1S_0249	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A1S_0254	COG0697	spore germination
A1S_0255	COG1538	Outer membrane efflux protein
A1S_0260	COG3275	phosphorelay sensor kinase activity
A1S_0262	COG0181	hydroxymethylbilane synthase activity
A1S_0272	COG1716	ATPase activity
A1S_0273	COG0546	phosphoglycolate phosphatase activity
A1S_0290	COG0596	Alpha beta hydrolase
A1S_0291	COG2056	Na+-H+ antiporter family
A1S_0298	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A1S_0312	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A1S_0319	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A1S_0321	COG0497	DNA recombination
A1S_0324	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1S_0326	COG0237	dephospho-CoA kinase activity
A1S_0335	COG0195	Participates in both transcription termination and antitermination
A1S_0341	COG0651	ATP synthesis coupled electron transport
A1S_0342	COG1006	Multisubunit Na H antiporter MnhC subunit
A1S_0343	COG2111	Na H antiporter
A1S_0343	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A1S_0346	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A1S_0350	COG2226	methyltransferase
A1S_0354	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A1S_0357	COG1074	ATP-dependent DNA helicase activity
A1S_0358	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A1S_0362	COG0598	Magnesium transport protein CorA
A1S_0363	COG0789	Transcriptional regulator
A1S_0364	COG0484	heat shock protein binding
A1S_0367	COG0475	glutathione-regulated potassium exporter activity
A1S_0367	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A1S_0368	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A1S_0372	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1S_0375	COG4535	Mg2 and Co2 transporter CorC
A1S_0376	COG0425	Belongs to the sulfur carrier protein TusA family
A1S_0378	COG0644	oxidoreductase
A1S_0378	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
A1S_0380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A1S_0383	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1S_0385	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A1S_0392	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A1S_0395	COG0534	Mate efflux family protein
A1S_0397	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A1S_0398	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_0399	COG0583	DNA-binding transcription factor activity
A1S_0403	COG1530	ribonuclease E activity
A1S_0406	COG0546	phosphoglycolate phosphatase activity
A1S_0407	COG2378	regulation of single-species biofilm formation
A1S_0408	COG0625	glutathione transferase activity
A1S_0410	COG0583	DNA-binding transcription factor activity
A1S_0420	COG0473	3-isopropylmalate dehydrogenase activity
A1S_0429	COG1301	dicarboxylic acid transport
A1S_0431	COG1560	Kdo2-lipid A biosynthetic process
A1S_0432	COG1280	lysine exporter protein (LysE YggA)
A1S_0437	COG1733	regulation of RNA biosynthetic process
A1S_0442	COG0210	DNA helicase
A1S_0443	COG0724	RNA recognition motif
A1S_0446	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A1S_0446	COG4651	solute:proton antiporter activity
A1S_0447	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A1S_0448	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A1S_0451	COG0788	formyltetrahydrofolate deformylase activity
A1S_0470	COG2813	Specifically methylates the guanine in position
A1S_0470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A1S_0472	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A1S_0474	COG4774	siderophore transport
A1S_0476	COG0740	serine-type endopeptidase activity
A1S_0480	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A1S_0480	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A1S_0481	COG0280	phosphate acetyltransferase
A1S_0481	COG0857	belongs to the CobB CobQ family
A1S_0482	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A1S_0484	COG0800	Aldolase
A1S_0485	COG2610	gluconate transmembrane transporter activity
A1S_0486	COG3265	gluconokinase activity
A1S_0490	COG2267	carboxylic ester hydrolase activity
A1S_0493	COG0793	Belongs to the peptidase S41A family
A1S_0494	COG0438	transferase activity, transferring glycosyl groups
A1S_0501	COG1426	Protein conserved in bacteria
A1S_0510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1S_0512	COG0318	PFAM AMP-dependent synthetase and ligase
A1S_0513	COG1216	Glycosyl transferase, family 2
A1S_0515	COG2986	histidine ammonia-lyase
A1S_0524	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_0525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1S_0529	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A1S_0531	COG1162	GTPase activity
A1S_0532	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A1S_0535	COG1538	Outer membrane efflux protein
A1S_0536	COG1136	(ABC) transporter
A1S_0536	COG0577	efflux transmembrane transporter activity
A1S_0538	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1S_0543	COG0028	Belongs to the TPP enzyme family
A1S_0544	COG0440	acetolactate synthase activity
A1S_0550	COG3501	Rhs element vgr protein
A1S_0554	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A1S_0557	COG0084	hydrolase, TatD family'
A1S_0559	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A1S_0560	COG0583	DNA-binding transcription factor activity
A1S_0562	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A1S_0563	COG2814	Major facilitator Superfamily
A1S_0565	COG0697	spore germination
A1S_0566	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A1S_0567	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A1S_0568	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A1S_0571	COG3622	Belongs to the hyi family
A1S_0572	COG2084	Dehydrogenase
A1S_0573	COG1024	Enoyl-CoA hydratase
A1S_0574	COG5002	protein histidine kinase activity
A1S_0574	COG2205	protein histidine kinase activity
A1S_0574	COG0784	Response regulator, receiver
A1S_0579	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1S_0581	COG3956	TIGRFAM MazG family protein
A1S_0582	COG1555	photosystem II stabilization
A1S_0583	COG0617	tRNA 3'-terminal CCA addition
A1S_0584	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A1S_0589	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1S_0590	COG3028	Belongs to the UPF0307 family
A1S_0591	COG0318	PFAM AMP-dependent synthetase and ligase
A1S_0594	COG0625	glutathione transferase activity
A1S_0595	COG1238	metal cluster binding
A1S_0597	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A1S_0602	COG0072	phenylalanine-tRNA ligase activity
A1S_0607	COG0248	Ppx GppA phosphatase
A1S_0609	COG0037	tRNA processing
A1S_0617	COG1764	response to oxidative stress
A1S_0618	COG1846	Transcriptional regulator
A1S_0619	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1S_0624	COG0501	Belongs to the peptidase M48B family
A1S_0634	COG0739	heme binding
A1S_0637	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A1S_0639	COG1192	Involved in chromosome partitioning
A1S_0643	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A1S_0648	COG1525	nuclease
A1S_0651	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A1S_0669	COG0798	PFAM Bile acid sodium symporter
A1S_0685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A1S_0686	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A1S_0687	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A1S_0689	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A1S_0699	COG1214	PFAM Peptidase M22, glycoprotease
A1S_0705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A1S_0706	COG0561	phosphatase activity
A1S_0707	COG2132	Multicopper oxidase
A1S_0711	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A1S_0712	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A1S_0713	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A1S_0719	COG1063	alcohol dehydrogenase
A1S_0720	COG0583	DNA-binding transcription factor activity
A1S_0721	COG1960	acyl-CoA dehydrogenase activity
A1S_0722	COG2814	Major facilitator Superfamily
A1S_0723	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A1S_0725	COG1053	succinate dehydrogenase
A1S_0726	COG0583	DNA-binding transcription factor activity
A1S_0729	COG0583	DNA-binding transcription factor activity
A1S_0731	COG1473	amidohydrolase
A1S_0735	COG0583	DNA-binding transcription factor activity
A1S_0737	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A1S_0738	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A1S_0746	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1S_0748	COG0745	RESPONSE REGULATOR receiver
A1S_0749	COG2205	protein histidine kinase activity
A1S_0756	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A1S_0762	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A1S_0763	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1S_0768	COG0583	DNA-binding transcription factor activity
A1S_0771	COG0668	transmembrane transport
A1S_0772	COG2081	HI0933 family
A1S_0773	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A1S_0778	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1S_0778	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1S_0780	COG0489	protein tyrosine kinase activity
A1S_0789	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A1S_0795	COG0730	response to heat
A1S_0797	COG1196	nuclear chromosome segregation
A1S_0801	COG2223	nitrite transmembrane transporter activity
A1S_0803	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A1S_0804	COG1877	trehalose-phosphatase activity
A1S_0805	COG0596	Alpha beta hydrolase
A1S_0805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A1S_0805	COG2226	methyltransferase
A1S_0808	COG4106	trans-aconitate 2-methyltransferase activity
A1S_0811	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A1S_0812	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A1S_0813	COG0009	L-threonylcarbamoyladenylate synthase
A1S_0814	COG3101	peptidyl-lysine hydroxylation
A1S_0815	COG1399	metal-binding, possibly nucleic acid-binding protein
A1S_0820	COG1652	LysM domain
A1S_0821	COG0352	thiamine-phosphate diphosphorylase activity
A1S_0821	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A1S_0821	COG0351	phosphomethylpyrimidine kinase
A1S_0823	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A1S_0829	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A1S_0835	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A1S_0838	COG0358	DNA primase activity
A1S_0839	COG0358	DNA primase activity
A1S_0841	COG0564	pseudouridine synthase activity
A1S_0848	COG0583	DNA-binding transcription factor activity
A1S_0849	COG0473	3-isopropylmalate dehydrogenase activity
A1S_0854	COG1012	belongs to the aldehyde dehydrogenase family
A1S_0858	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1S_0858	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A1S_0859	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A1S_0859	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A1S_0863	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1S_0872	COG0456	acetyltransferase
A1S_0874	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A1S_0875	COG0492	ferredoxin-NADP+ reductase activity
A1S_0876	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A1S_0876	COG1674	ftsk spoiiie
A1S_0877	COG1280	lysine exporter protein (LysE YggA)
A1S_0880	COG2894	cell division
A1S_0883	COG0204	Acyl-transferase
A1S_0884	COG2885	chlorophyll binding
A1S_0885	COG0210	DNA helicase
A1S_0887	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A1S_0890	COG0121	glutamine amidotransferase
A1S_0894	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1S_0895	COG0735	belongs to the Fur family
A1S_0900	COG0420	3'-5' exonuclease activity
A1S_0904	COG1090	epimerase
A1S_0907	COG2050	protein possibly involved in aromatic compounds catabolism
A1S_0909	COG2814	Major facilitator Superfamily
A1S_0910	COG0405	Gamma-glutamyltransferase
A1S_0915	COG0477	Major facilitator Superfamily
A1S_0916	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A1S_0921	COG0531	amino acid
A1S_0922	COG2040	homocysteine
A1S_0928	COG1309	transcriptional regulator
A1S_0929	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A1S_0930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A1S_0931	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A1S_0933	COG1607	acyl-coa hydrolase
A1S_0934	COG0523	cobalamin synthesis protein
A1S_0936	COG4681	YaeQ
A1S_0938	COG1649	PFAM Uncharacterised BCR, COG1649
A1S_0938	COG0726	polysaccharide deacetylase
A1S_0939	COG1215	transferase activity, transferring glycosyl groups
A1S_0941	COG1024	Enoyl-CoA hydratase
A1S_0944	COG1414	Transcriptional regulator
A1S_0948	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_0950	COG0446	pyridine nucleotide-disulphide oxidoreductase
A1S_0952	COG2271	Major facilitator Superfamily
A1S_0954	COG2267	carboxylic ester hydrolase activity
A1S_0955	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_0958	COG0028	Belongs to the TPP enzyme family
A1S_0960	COG0477	Major facilitator Superfamily
A1S_0961	COG0242	peptide deformylase activity
A1S_0962	COG2066	Belongs to the glutaminase family
A1S_0963	COG2207	Transcriptional regulator
A1S_0964	COG2223	nitrite transmembrane transporter activity
A1S_0966	COG0583	DNA-binding transcription factor activity
A1S_0967	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_0968	COG2271	Major facilitator Superfamily
A1S_0969	COG3959	Transketolase, thiamine diphosphate binding domain
A1S_0970	COG3958	Transketolase
A1S_0972	COG0306	phosphate transporter
A1S_0976	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A1S_0986	COG4181	ATPase activity
A1S_0987	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A1S_0992	COG0583	DNA-binding transcription factor activity
A1S_0994	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A1S_0995	COG1773	rubredoxin
A1S_1004	COG2851	Citrate transporter
A1S_1005	COG1253	flavin adenine dinucleotide binding
A1S_1006	COG0583	DNA-binding transcription factor activity
A1S_1014	COG0804	urea catabolic process
A1S_1016	COG0830	nickel cation binding
A1S_1019	COG0742	ribosomal rna small subunit methyltransferase
A1S_1020	COG0768	penicillin binding
A1S_1024	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A1S_1025	COG2878	Part of a membrane complex involved in electron transport
A1S_1026	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A1S_1028	COG3384	dioxygenase
A1S_1034	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A1S_1039	COG0006	proline dipeptidase activity
A1S_1040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1S_1041	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1S_1046	COG1279	arginine transmembrane transporter activity
A1S_1047	COG0583	DNA-binding transcription factor activity
A1S_1054	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1S_1055	COG1388	LysM domain
A1S_1055	COG0741	lytic transglycosylase activity
A1S_1055	COG0741	lytic transglycosylase activity
A1S_1055	COG1388	LysM domain
A1S_1057	COG4174	ABC transporter (Permease)
A1S_1058	COG4239	(ABC) transporter, permease
A1S_1060	COG4172	Belongs to the ABC transporter superfamily
A1S_1061	COG4172	Belongs to the ABC transporter superfamily
A1S_1065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A1S_1067	COG5001	Diguanylate cyclase
A1S_1067	COG3706	GGDEF domain
A1S_1067	COG4251	negative regulation of phosphorylation
A1S_1067	COG2203	Gaf domain
A1S_1070	COG1902	pentaerythritol trinitrate reductase activity
A1S_1070	COG0446	pyridine nucleotide-disulphide oxidoreductase
A1S_1074	COG0251	oxidation-reduction process
A1S_1076	COG0583	DNA-binding transcription factor activity
A1S_1083	COG1113	amino acid transport
A1S_1085	COG0531	amino acid
A1S_1089	COG1012	belongs to the aldehyde dehydrogenase family
A1S_1092	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A1S_1094	COG1113	amino acid transport
A1S_1097	COG0697	spore germination
A1S_1098	COG2721	sulfolactate sulfo-lyase activity
A1S_1099	COG2271	Major facilitator Superfamily
A1S_1100	COG4948	Mandelate Racemase Muconate Lactonizing
A1S_1102	COG1012	belongs to the aldehyde dehydrogenase family
A1S_1103	COG2186	Transcriptional regulator
A1S_1108	COG1960	acyl-CoA dehydrogenase activity
A1S_1110	COG1012	belongs to the aldehyde dehydrogenase family
A1S_1111	COG1024	Enoyl-CoA hydratase
A1S_1112	COG2814	Major facilitator Superfamily
A1S_1115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1S_1125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A1S_1126	COG2072	flavoprotein involved in K transport
A1S_1127	COG0300	oxidoreductase activity
A1S_1129	COG1309	transcriptional regulator
A1S_1130	COG1741	Belongs to the pirin family
A1S_1133	COG2072	flavoprotein involved in K transport
A1S_1136	COG2252	PERMEase
A1S_1137	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A1S_1138	COG3038	cytochrome b561
A1S_1140	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A1S_1144	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A1S_1145	COG4197	protein conserved in bacteria, prophage-related
A1S_1152	COG5410	chromosome segregation
A1S_1153	COG3567	Phage-associated protein, HI1409 family
A1S_1155	COG3566	protein conserved in bacteria
A1S_1175	COG0582	viral genome integration into host DNA
A1S_1179	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A1S_1181	COG0667	Aldo Keto reductase
A1S_1183	COG1765	OsmC-like protein
A1S_1193	COG2885	chlorophyll binding
A1S_1195	COG0625	glutathione transferase activity
A1S_1196	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A1S_1200	COG3634	alkyl hydroperoxide reductase activity
A1S_1201	COG3634	alkyl hydroperoxide reductase activity
A1S_1203	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A1S_1205	COG0450	alkyl hydroperoxide reductase
A1S_1206	COG1643	Atp-dependent helicase
A1S_1210	COG2814	Major facilitator Superfamily
A1S_1211	COG3135	benzoate transporter
A1S_1212	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_1213	COG0543	2 iron, 2 sulfur cluster binding
A1S_1213	COG0633	Ferredoxin
A1S_1214	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
A1S_1215	COG4638	Rieske (2fe-2S)
A1S_1216	COG0583	DNA-binding transcription factor activity
A1S_1222	COG1570	exodeoxyribonuclease VII activity
A1S_1227	COG1280	lysine exporter protein (LysE YggA)
A1S_1228	COG1278	Cold shock
A1S_1231	COG2814	Major facilitator Superfamily
A1S_1232	COG1733	regulation of RNA biosynthetic process
A1S_1236	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A1S_1236	COG0517	IMP dehydrogenase activity
A1S_1237	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A1S_1239	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A1S_1240	COG1137	ATPase activity
A1S_1241	COG1538	Outer membrane efflux protein
A1S_1249	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A1S_1253	COG5006	permease, DMT superfamily
A1S_1255	COG1560	Kdo2-lipid A biosynthetic process
A1S_1257	COG2814	Major facilitator Superfamily
A1S_1261	COG1250	3-hydroxyacyl-CoA dehydrogenase
A1S_1263	COG1011	Hydrolase
A1S_1265	COG0583	DNA-binding transcription factor activity
A1S_1266	COG1914	H( )-stimulated, divalent metal cation uptake system
A1S_1270	COG4770	biotin carboxylase activity
A1S_1271	COG0038	chloride channel
A1S_1272	COG1309	transcriptional regulator
A1S_1274	COG1063	alcohol dehydrogenase
A1S_1277	COG0439	Biotin carboxylase
A1S_1278	COG0511	ligase activity, forming carbon-carbon bonds
A1S_1279	COG2249	NAD(P)H dehydrogenase (quinone) activity
A1S_1280	COG1733	regulation of RNA biosynthetic process
A1S_1282	COG0864	Transcriptional regulator
A1S_1284	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1S_1285	COG1116	anion transmembrane transporter activity
A1S_1291	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A1S_1305	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A1S_1305	COG2885	chlorophyll binding
A1S_1313	COG0583	DNA-binding transcription factor activity
A1S_1315	COG0590	tRNA wobble adenosine to inosine editing
A1S_1316	COG2807	transmembrane transport
A1S_1319	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A1S_1320	COG0789	Transcriptional regulator
A1S_1322	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A1S_1326	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A1S_1332	COG1012	belongs to the aldehyde dehydrogenase family
A1S_1333	COG0531	amino acid
A1S_1334	COG1760	l-serine dehydratase
A1S_1335	COG2030	dehydratase
A1S_1335	COG1012	belongs to the aldehyde dehydrogenase family
A1S_1336	COG3396	Phenylacetate-CoA oxygenase
A1S_1337	COG3460	Phenylacetate-CoA oxygenase
A1S_1338	COG3396	Phenylacetate-CoA oxygenase
A1S_1339	COG2151	metal-sulfur cluster biosynthetic enzyme
A1S_1340	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1S_1341	COG1024	Enoyl-CoA hydratase
A1S_1342	COG1024	Enoyl-CoA hydratase
A1S_1343	COG1250	3-hydroxyacyl-CoA dehydrogenase
A1S_1344	COG0183	Belongs to the thiolase family
A1S_1345	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A1S_1346	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A1S_1347	COG3327	negative regulation of DNA-templated transcription, initiation
A1S_1349	COG2050	protein possibly involved in aromatic compounds catabolism
A1S_1351	COG0753	catalase activity
A1S_1352	COG3038	cytochrome b561
A1S_1353	COG0583	DNA-binding transcription factor activity
A1S_1355	COG1414	Transcriptional regulator
A1S_1356	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1S_1359	COG1840	ABC-type Fe3 transport system, periplasmic component
A1S_1360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A1S_1361	COG3842	ATPase activity
A1S_1364	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A1S_1365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A1S_1366	COG1280	lysine exporter protein (LysE YggA)
A1S_1371	COG0583	DNA-binding transcription factor activity
A1S_1374	COG1024	Enoyl-CoA hydratase
A1S_1375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A1S_1376	COG1960	acyl-CoA dehydrogenase activity
A1S_1377	COG1309	transcriptional regulator
A1S_1378	COG0318	PFAM AMP-dependent synthetase and ligase
A1S_1382	COG0583	DNA-binding transcription factor activity
A1S_1387	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_1393	COG2205	protein histidine kinase activity
A1S_1393	COG0784	Response regulator, receiver
A1S_1397	COG0765	amino acid transport
A1S_1399	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1S_1400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1S_1403	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A1S_1404	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A1S_1405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A1S_1406	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A1S_1407	COG1045	serine acetyltransferase
A1S_1410	COG0583	DNA-binding transcription factor activity
A1S_1411	COG0625	glutathione transferase activity
A1S_1412	COG0625	glutathione transferase activity
A1S_1413	COG0583	DNA-binding transcription factor activity
A1S_1414	COG1346	cytolysis
A1S_1415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1S_1418	COG2814	Major facilitator Superfamily
A1S_1420	COG0583	DNA-binding transcription factor activity
A1S_1422	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A1S_1423	COG3052	prosthetic group binding
A1S_1427	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A1S_1432	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1S_1433	COG1294	oxidase, subunit
A1S_1434	COG1271	oxidase subunit
A1S_1440	COG0477	Major facilitator Superfamily
A1S_1442	COG4521	taurine ABC transporter
A1S_1443	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A1S_1444	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A1S_1445	COG2175	clavaminate synthase activity
A1S_1447	COG1953	Uracil, thiamine, allantoin
A1S_1449	COG0583	DNA-binding transcription factor activity
A1S_1451	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A1S_1453	COG0640	Transcriptional regulator
A1S_1454	COG0798	PFAM Bile acid sodium symporter
A1S_1455	COG0583	DNA-binding transcription factor activity
A1S_1458	COG3634	alkyl hydroperoxide reductase activity
A1S_1459	COG3634	alkyl hydroperoxide reductase activity
A1S_1460	COG3634	alkyl hydroperoxide reductase activity
A1S_1468	COG0436	Aminotransferase
A1S_1470	COG0386	Belongs to the glutathione peroxidase family
A1S_1477	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A1S_1481	COG0012	GTP binding
A1S_1482	COG2011	ABC-type metal ion transport system permease component
A1S_1483	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A1S_1485	COG1464	Belongs to the NlpA lipoprotein family
A1S_1491	COG0765	amino acid transport
A1S_1492	COG0765	amino acid transport
A1S_1493	COG1126	abc transporter atp-binding protein
A1S_1495	COG1522	sequence-specific DNA binding
A1S_1498	COG1309	transcriptional regulator
A1S_1502	COG0583	DNA-binding transcription factor activity
A1S_1504	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A1S_1505	COG0697	spore germination
A1S_1509	COG3121	Chaperone
A1S_1510	COG3539	Fimbrial protein
A1S_1513	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A1S_1513	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A1S_1520	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A1S_1521	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A1S_1523	COG2353	YceI-like domain
A1S_1525	COG3698	Phosphodiester glycosidase
A1S_1528	COG0506	proline dehydrogenase activity
A1S_1528	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A1S_1528	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
A1S_1530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A1S_1531	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A1S_1535	COG1132	(ABC) transporter
A1S_1536	COG3122	Protein conserved in bacteria
A1S_1537	COG3619	membrane
A1S_1539	COG0640	Transcriptional regulator
A1S_1541	COG2850	peptidyl-arginine hydroxylation
A1S_1542	COG0424	maF-like protein
A1S_1544	COG0191	fructose-bisphosphate aldolase activity
A1S_1545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A1S_1549	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A1S_1551	COG1192	Involved in chromosome partitioning
A1S_1552	COG1475	DNA binding
A1S_1553	COG0811	peptide transport
A1S_1555	COG1132	(ABC) transporter
A1S_1556	COG1663	tetraacyldisaccharide 4'-kinase activity
A1S_1560	COG0084	hydrolase, TatD family'
A1S_1569	COG0590	tRNA wobble adenosine to inosine editing
A1S_1573	COG0776	regulation of translation
A1S_1579	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A1S_1585	COG0305	Participates in initiation and elongation during chromosome replication
A1S_1589	COG4695	Portal protein
A1S_1601	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A1S_1610	COG0339	signal peptide processing
A1S_1612	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A1S_1618	COG0702	epimerase
A1S_1619	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A1S_1623	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A1S_1630	COG0316	Belongs to the HesB IscA family
A1S_1631	COG0822	iron-sulfur transferase activity
A1S_1637	COG0776	regulation of translation
A1S_1638	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A1S_1640	COG2207	Transcriptional regulator
A1S_1641	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1S_1642	COG1960	acyl-CoA dehydrogenase activity
A1S_1643	COG1960	acyl-CoA dehydrogenase activity
A1S_1646	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A1S_1649	COG2814	Major facilitator Superfamily
A1S_1650	COG4264	IucA IucC family
A1S_1651	COG4264	IucA IucC family
A1S_1652	COG4264	IucA IucC family
A1S_1654	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A1S_1658	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A1S_1660	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A1S_1661	COG0406	alpha-ribazole phosphatase activity
A1S_1664	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A1S_1665	COG0730	response to heat
A1S_1667	COG4773	Receptor
A1S_1668	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A1S_1671	COG1131	(ABC) transporter
A1S_1672	COG0842	Transport permease protein
A1S_1673	COG0842	Transport permease protein
A1S_1681	COG2226	methyltransferase
A1S_1685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A1S_1686	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A1S_1690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A1S_1692	COG0133	tryptophan synthase activity
A1S_1695	COG3706	GGDEF domain
A1S_1698	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A1S_1699	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A1S_1700	COG0022	dehydrogenase e1 component
A1S_1701	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1S_1702	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1S_1703	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1S_1705	COG1063	alcohol dehydrogenase
A1S_1706	COG3781	membrane
A1S_1708	COG3453	Protein conserved in bacteria
A1S_1708	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1S_1710	COG0730	response to heat
A1S_1713	COG3708	Transcriptional regulator
A1S_1713	COG2207	Transcriptional regulator
A1S_1714	COG1733	regulation of RNA biosynthetic process
A1S_1715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A1S_1720	COG4521	taurine ABC transporter
A1S_1721	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A1S_1724	COG0477	Major facilitator Superfamily
A1S_1726	COG1027	Aspartate ammonia-lyase
A1S_1727	COG0583	DNA-binding transcription factor activity
A1S_1728	COG0583	DNA-binding transcription factor activity
A1S_1729	COG0183	Belongs to the thiolase family
A1S_1730	COG2031	fatty acid transporter
A1S_1733	COG0583	DNA-binding transcription factor activity
A1S_1736	COG2610	gluconate transmembrane transporter activity
A1S_1737	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_1738	COG2207	Transcriptional regulator
A1S_1739	COG2271	Major facilitator Superfamily
A1S_1740	COG2271	Major facilitator Superfamily
A1S_1741	COG0412	Dienelactone hydrolase
A1S_1742	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_1744	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A1S_1747	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1S_1747	COG0543	2 iron, 2 sulfur cluster binding
A1S_1750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1S_1751	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1S_1753	COG0745	RESPONSE REGULATOR receiver
A1S_1754	COG2205	protein histidine kinase activity
A1S_1756	COG2207	Transcriptional regulator
A1S_1762	COG2856	Zn peptidase
A1S_1767	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A1S_1785	COG1120	ATPase activity
A1S_1788	COG1064	alcohol dehydrogenase
A1S_1789	COG2207	Transcriptional regulator
A1S_1790	COG2084	Dehydrogenase
A1S_1792	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1S_1793	COG0583	DNA-binding transcription factor activity
A1S_1795	COG0129	dihydroxy-acid dehydratase activity
A1S_1796	COG1012	belongs to the aldehyde dehydrogenase family
A1S_1797	COG1012	belongs to the aldehyde dehydrogenase family
A1S_1800	COG1566	PFAM secretion protein HlyD family protein
A1S_1801	COG1566	PFAM secretion protein HlyD family protein
A1S_1804	COG0583	DNA-binding transcription factor activity
A1S_1815	COG0318	PFAM AMP-dependent synthetase and ligase
A1S_1817	COG1960	acyl-CoA dehydrogenase activity
A1S_1819	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_1820	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_1821	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_1822	COG0583	DNA-binding transcription factor activity
A1S_1823	COG1309	transcriptional regulator
A1S_1828	COG0789	Transcriptional regulator
A1S_1830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A1S_1832	COG0446	pyridine nucleotide-disulphide oxidoreductase
A1S_1832	COG1902	pentaerythritol trinitrate reductase activity
A1S_1835	COG1012	belongs to the aldehyde dehydrogenase family
A1S_1840	COG2186	Transcriptional regulator
A1S_1842	COG0583	DNA-binding transcription factor activity
A1S_1843	COG4948	Mandelate Racemase Muconate Lactonizing
A1S_1844	COG4829	muconolactone delta-isomerase
A1S_1846	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A1S_1847	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A1S_1848	COG0183	Belongs to the thiolase family
A1S_1849	COG0183	Belongs to the thiolase family
A1S_1850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A1S_1852	COG1012	belongs to the aldehyde dehydrogenase family
A1S_1854	COG3733	amine oxidase
A1S_1856	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A1S_1858	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_1861	COG4638	Rieske (2fe-2S)
A1S_1865	COG0154	amidase activity
A1S_1867	COG2814	Major facilitator Superfamily
A1S_1873	COG1960	acyl-CoA dehydrogenase activity
A1S_1874	COG0583	DNA-binding transcription factor activity
A1S_1875	COG1414	Transcriptional regulator
A1S_1878	COG2391	methyltransferase activity
A1S_1880	COG4993	Dehydrogenase
A1S_1881	COG3659	wide pore channel activity
A1S_1882	COG3420	alginic acid biosynthetic process
A1S_1883	COG0710	3-dehydroquinate dehydratase activity
A1S_1884	COG3485	protocatechuate 3,4-dioxygenase
A1S_1885	COG3485	protocatechuate 3,4-dioxygenase
A1S_1886	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A1S_1887	COG2271	Major facilitator Superfamily
A1S_1888	COG2271	Major facilitator Superfamily
A1S_1889	COG0596	Alpha beta hydrolase
A1S_1890	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A1S_1891	COG0183	Belongs to the thiolase family
A1S_1892	COG0183	Belongs to the thiolase family
A1S_1893	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A1S_1894	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A1S_1896	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A1S_1897	COG2323	membrane
A1S_1905	COG0446	pyridine nucleotide-disulphide oxidoreductase
A1S_1905	COG1902	pentaerythritol trinitrate reductase activity
A1S_1908	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A1S_1910	COG0542	response to heat
A1S_1911	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A1S_1916	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A1S_1917	COG0569	domain protein
A1S_1918	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A1S_1921	COG4774	siderophore transport
A1S_1922	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A1S_1923	COG1585	Membrane protein implicated in regulation of membrane protease activity
A1S_1925	COG1294	oxidase, subunit
A1S_1928	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
A1S_1930	COG0552	protein localization to endoplasmic reticulum
A1S_1935	COG0516	GMP reductase activity
A1S_1935	COG0517	IMP dehydrogenase activity
A1S_1936	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A1S_1937	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A1S_1939	COG0583	DNA-binding transcription factor activity
A1S_1940	COG0024	Methionine aminopeptidase
A1S_1945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A1S_1945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A1S_1946	COG1105	Belongs to the carbohydrate kinase PfkB family
A1S_1947	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A1S_1947	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1S_1947	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A1S_1949	COG3300	MHYT domain
A1S_1949	COG5001	Diguanylate cyclase
A1S_1952	COG2135	peptidase activity
A1S_1953	COG0659	secondary active sulfate transmembrane transporter activity
A1S_1956	COG1113	amino acid transport
A1S_1958	COG1522	sequence-specific DNA binding
A1S_1960	COG1011	Hydrolase
A1S_1961	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A1S_1963	COG2137	regulation of response to DNA damage stimulus
A1S_1965	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A1S_1969	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1S_1972	COG0575	Belongs to the CDS family
A1S_1973	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A1S_1977	COG3852	Histidine kinase
A1S_1978	COG2204	response regulator
A1S_1987	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A1S_1988	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
A1S_1992	COG0697	spore germination
A1S_1993	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1S_1995	COG0303	'Molybdopterin
A1S_1996	COG0315	cyclic pyranopterin monophosphate synthase activity
A1S_1996	COG0521	Mo-molybdopterin cofactor biosynthetic process
A1S_1999	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A1S_2000	COG0243	molybdopterin cofactor binding
A1S_2002	COG0243	molybdopterin cofactor binding
A1S_2003	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A1S_2004	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A1S_2005	COG2146	nitrite reductase [NAD(P)H] activity
A1S_2005	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A1S_2006	COG0745	RESPONSE REGULATOR receiver
A1S_2007	COG1116	anion transmembrane transporter activity
A1S_2007	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A1S_2010	COG0511	ligase activity, forming carbon-carbon bonds
A1S_2013	COG2814	Major facilitator Superfamily
A1S_2015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A1S_2019	COG1598	PFAM Uncharacterised protein family UPF0150
A1S_2030	COG5410	chromosome segregation
A1S_2034	COG3617	BRO family, N-terminal domain
A1S_2044	COG0069	glutamate synthase activity
A1S_2046	COG0069	glutamate synthase activity
A1S_2051	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A1S_2053	COG1454	alcohol dehydrogenase
A1S_2054	COG0824	Thioesterase
A1S_2056	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A1S_2062	COG0183	Belongs to the thiolase family
A1S_2064	COG0583	DNA-binding transcription factor activity
A1S_2067	COG1522	sequence-specific DNA binding
A1S_2068	COG3135	benzoate transporter
A1S_2070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A1S_2072	COG0589	response to stress
A1S_2073	COG0488	(ABC) transporter
A1S_2076	COG4773	Receptor
A1S_2077	COG4773	Receptor
A1S_2079	COG0668	transmembrane transport
A1S_2082	COG1309	transcriptional regulator
A1S_2084	COG1605	Chorismate mutase
A1S_2092	COG0308	aminopeptidase N
A1S_2097	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A1S_2098	COG1454	alcohol dehydrogenase
A1S_2103	COG0531	amino acid
A1S_2104	COG4303	Ethanolamine ammonia lyase large subunit
A1S_2105	COG4302	ethanolamine ammonia-lyase activity
A1S_2106	COG4302	ethanolamine ammonia-lyase activity
A1S_2107	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A1S_2107	COG0519	Catalyzes the synthesis of GMP from XMP
A1S_2112	COG0697	spore germination
A1S_2115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A1S_2116	COG0802	atpase or kinase
A1S_2120	COG1187	pseudouridine synthase activity
A1S_2122	COG0583	DNA-binding transcription factor activity
A1S_2124	COG2814	Major facilitator Superfamily
A1S_2125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A1S_2132	COG0729	surface antigen
A1S_2136	COG0174	glutamine synthetase
A1S_2137	COG0745	RESPONSE REGULATOR receiver
A1S_2138	COG2205	protein histidine kinase activity
A1S_2139	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A1S_2140	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A1S_2141	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A1S_2142	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A1S_2144	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A1S_2147	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A1S_2148	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A1S_2149	COG1960	acyl-CoA dehydrogenase activity
A1S_2156	COG0583	DNA-binding transcription factor activity
A1S_2158	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A1S_2160	COG1215	transferase activity, transferring glycosyl groups
A1S_2161	COG0726	polysaccharide deacetylase
A1S_2161	COG1649	PFAM Uncharacterised BCR, COG1649
A1S_2166	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A1S_2167	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A1S_2169	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A1S_2175	COG0305	Participates in initiation and elongation during chromosome replication
A1S_2176	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A1S_2178	COG1305	Transglutaminase-like
A1S_2180	COG2308	Evidence 4 Homologs of previously reported genes of
A1S_2186	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
A1S_2187	COG0138	bifunctional purine biosynthesis protein purh
A1S_2188	COG0138	bifunctional purine biosynthesis protein purh
A1S_2189	COG0151	Belongs to the GarS family
A1S_2190	COG1464	Belongs to the NlpA lipoprotein family
A1S_2192	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A1S_2193	COG2011	ABC-type metal ion transport system permease component
A1S_2194	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1S_2196	COG1301	dicarboxylic acid transport
A1S_2202	COG1794	racemase activity, acting on amino acids and derivatives
A1S_2204	COG3008	intermembrane lipid transfer
A1S_2204	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A1S_2205	COG2995	paraquat-inducible protein a
A1S_2211	COG1051	belongs to the nudix hydrolase family
A1S_2212	COG0477	Major facilitator Superfamily
A1S_2219	COG2186	Transcriptional regulator
A1S_2221	COG0786	glutamate:sodium symporter activity
A1S_2222	COG3243	poly(R)-hydroxyalkanoic acid synthase
A1S_2240	COG2815	serine threonine protein kinase
A1S_2240	COG0515	serine threonine protein kinase
A1S_2245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A1S_2246	COG1610	YqeY-like protein
A1S_2247	COG4783	chaperone-mediated protein folding
A1S_2252	COG1286	toxin biosynthetic process
A1S_2258	COG0778	Nitroreductase
A1S_2260	COG0513	Belongs to the DEAD box helicase family
A1S_2263	COG2363	Small membrane protein
A1S_2269	COG4650	regulator
A1S_2270	COG1234	tRNA 3'-trailer cleavage
A1S_2271	COG1690	Belongs to the RtcB family
A1S_2274	COG2195	Cleaves the N-terminal amino acid of tripeptides
A1S_2276	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A1S_2278	COG2819	hydrolase of the alpha beta superfamily
A1S_2279	COG1960	acyl-CoA dehydrogenase activity
A1S_2280	COG1301	dicarboxylic acid transport
A1S_2281	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A1S_2282	COG3139	Protein of unknown function (DUF1315)
A1S_2283	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A1S_2284	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A1S_2286	COG0494	nUDIX hydrolase
A1S_2287	COG0642	Histidine kinase
A1S_2288	COG0745	RESPONSE REGULATOR receiver
A1S_2292	COG1720	tRNA m6t6A37 methyltransferase activity
A1S_2295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1S_2297	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A1S_2299	COG4598	ABC transporter
A1S_2300	COG4160	amino acid transport
A1S_2301	COG4215	(ABC) transporter
A1S_2304	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1S_2306	COG1538	Outer membrane efflux protein
A1S_2311	COG1131	(ABC) transporter
A1S_2312	COG0842	Transport permease protein
A1S_2315	COG0772	Belongs to the SEDS family
A1S_2316	COG2951	lytic endotransglycosylase activity
A1S_2320	COG2207	Transcriptional regulator
A1S_2323	COG0052	Belongs to the universal ribosomal protein uS2 family
A1S_2324	COG0024	Methionine aminopeptidase
A1S_2326	COG2223	nitrite transmembrane transporter activity
A1S_2328	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1S_2329	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A1S_2330	COG1960	acyl-CoA dehydrogenase activity
A1S_2331	COG1960	acyl-CoA dehydrogenase activity
A1S_2334	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A1S_2335	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A1S_2336	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A1S_2342	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A1S_2343	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A1S_2349	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A1S_2353	COG3104	oligopeptide transport
A1S_2355	COG0512	Glutamine amidotransferase of anthranilate synthase
A1S_2356	COG0308	aminopeptidase N
A1S_2364	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A1S_2369	COG3739	integral membrane protein
A1S_2374	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A1S_2377	COG1122	ATPase activity
A1S_2380	COG3433	isochorismatase activity
A1S_2380	COG1535	isochorismatase
A1S_2381	COG1021	2,3-dihydroxybenzoate-AMP ligase
A1S_2382	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1S_2383	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1S_2385	COG4774	siderophore transport
A1S_2386	COG4607	ABC-type enterochelin transport system periplasmic component
A1S_2387	COG4604	ABC transporter, ATP-binding protein
A1S_2388	COG4605	iron ion homeostasis
A1S_2389	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A1S_2390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1S_2393	COG2964	Protein conserved in bacteria
A1S_2395	COG1741	Belongs to the pirin family
A1S_2399	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1S_2402	COG0596	Alpha beta hydrolase
A1S_2405	COG0583	DNA-binding transcription factor activity
A1S_2406	COG1335	isochorismatase
A1S_2416	COG2879	small protein
A1S_2417	COG1966	Carbon starvation protein
A1S_2418	COG1966	Carbon starvation protein
A1S_2422	COG4943	cyclic-guanylate-specific phosphodiesterase activity
A1S_2430	COG1067	ATP-dependent peptidase activity
A1S_2431	COG0583	DNA-binding transcription factor activity
A1S_2435	COG1686	Belongs to the peptidase S11 family
A1S_2436	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A1S_2444	COG0616	signal peptide processing
A1S_2445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A1S_2447	COG0573	inorganic phosphate transmembrane transporter activity
A1S_2448	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A1S_2449	COG1113	amino acid transport
A1S_2450	COG3961	Belongs to the TPP enzyme family
A1S_2451	COG1522	sequence-specific DNA binding
A1S_2453	COG0076	glutamate decarboxylase activity
A1S_2454	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A1S_2457	COG2249	NAD(P)H dehydrogenase (quinone) activity
A1S_2459	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1S_2465	COG0352	thiamine-phosphate diphosphorylase activity
A1S_2470	COG0612	Peptidase, M16
A1S_2473	COG0583	DNA-binding transcription factor activity
A1S_2476	COG1187	pseudouridine synthase activity
A1S_2479	COG1686	Belongs to the peptidase S11 family
A1S_2480	COG1252	NADH dehydrogenase
A1S_2482	COG0415	Belongs to the DNA photolyase family
A1S_2485	COG1215	transferase activity, transferring glycosyl groups
A1S_2493	COG2070	2-Nitropropane dioxygenase
A1S_2504	COG0556	nucleotide-excision repair
A1S_2510	COG0443	Heat shock 70 kDa protein
A1S_2514	COG4221	oxidoreductase activity
A1S_2516	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A1S_2517	COG1381	Involved in DNA repair and RecF pathway recombination
A1S_2518	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A1S_2521	COG0681	Belongs to the peptidase S26 family
A1S_2523	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A1S_2525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1S_2529	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A1S_2531	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A1S_2532	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A1S_2534	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A1S_2535	COG4208	sulfate ABC transporter
A1S_2536	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A1S_2537	COG0583	DNA-binding transcription factor activity
A1S_2538	COG4625	pathogenesis
A1S_2540	COG0602	queuosine metabolic process
A1S_2542	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A1S_2545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A1S_2547	COG1056	cytidyltransferase-related domain
A1S_2547	COG1051	belongs to the nudix hydrolase family
A1S_2548	COG1024	Enoyl-CoA hydratase
A1S_2549	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A1S_2560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1S_2562	COG0534	Mate efflux family protein
A1S_2567	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A1S_2571	COG0019	diaminopimelate decarboxylase activity
A1S_2572	COG3486	L-lysine 6-monooxygenase (NADPH) activity
A1S_2574	COG1021	2,3-dihydroxybenzoate-AMP ligase
A1S_2575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1S_2578	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1S_2579	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_2580	COG1535	isochorismatase
A1S_2580	COG3433	isochorismatase activity
A1S_2581	COG1169	isochorismate synthase
A1S_2584	COG2814	Major facilitator Superfamily
A1S_2585	COG0047	phosphoribosylformylglycinamidine synthase activity
A1S_2585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A1S_2589	COG1473	amidohydrolase
A1S_2590	COG0824	Thioesterase
A1S_2594	COG0823	Involved in the tonB-independent uptake of proteins
A1S_2597	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1S_2604	COG0628	permease
A1S_2606	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A1S_2607	COG0596	Alpha beta hydrolase
A1S_2608	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A1S_2608	COG0616	signal peptide processing
A1S_2610	COG0658	competence protein
A1S_2610	COG2333	competence protein COMEC
A1S_2611	COG1136	(ABC) transporter
A1S_2612	COG4591	ABC-type transport system involved in lipoprotein release permease component
A1S_2620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1S_2624	COG0463	Glycosyl transferase, family 2
A1S_2629	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A1S_2630	COG1280	lysine exporter protein (LysE YggA)
A1S_2632	COG0019	diaminopimelate decarboxylase activity
A1S_2633	COG1113	amino acid transport
A1S_2636	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
A1S_2638	COG3339	Conserved Protein
A1S_2639	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A1S_2640	COG0243	molybdopterin cofactor binding
A1S_2641	COG1929	Belongs to the glycerate kinase type-1 family
A1S_2644	COG0778	Nitroreductase
A1S_2651	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1S_2653	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A1S_2657	COG0741	lytic transglycosylase activity
A1S_2661	COG0584	glycerophosphoryl diester phosphodiesterase
A1S_2662	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1S_2666	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A1S_2670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A1S_2671	COG0477	Major facilitator Superfamily
A1S_2680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A1S_2681	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A1S_2686	COG0505	Belongs to the CarA family
A1S_2689	COG1309	transcriptional regulator
A1S_2690	COG0251	oxidation-reduction process
A1S_2692	COG0589	response to stress
A1S_2694	COG2843	Capsule synthesis protein
A1S_2697	COG1648	precorrin-2 dehydrogenase activity
A1S_2697	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A1S_2698	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A1S_2699	COG1733	regulation of RNA biosynthetic process
A1S_2701	COG0531	amino acid
A1S_2704	COG0321	lipoyl(octanoyl) transferase activity
A1S_2705	COG2921	Belongs to the UPF0250 family
A1S_2711	COG2009	succinate dehydrogenase
A1S_2712	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
A1S_2713	COG1053	succinate dehydrogenase
A1S_2714	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A1S_2717	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1S_2721	COG2354	Protein conserved in bacteria
A1S_2722	COG2321	neutral zinc metallopeptidase
A1S_2725	COG1648	precorrin-2 dehydrogenase activity
A1S_2725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A1S_2729	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A1S_2734	COG0671	phosphoesterase, PA-phosphatase related
A1S_2735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1S_2737	COG1538	Outer membrane efflux protein
A1S_2738	COG0393	Putative heavy-metal-binding
A1S_2739	COG0393	Putative heavy-metal-binding
A1S_2740	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_2742	COG0525	valine-tRNA ligase activity
A1S_2743	COG0525	valine-tRNA ligase activity
A1S_2747	COG0583	DNA-binding transcription factor activity
A1S_2748	COG0004	ammonium transporteR
A1S_2750	COG0642	Histidine kinase
A1S_2751	COG0745	RESPONSE REGULATOR receiver
A1S_2752	COG2194	sulfuric ester hydrolase activity
A1S_2756	COG1752	Esterase of the alpha-beta hydrolase superfamily
A1S_2759	COG2315	Protein conserved in bacteria
A1S_2760	COG0142	geranyltranstransferase activity
A1S_2761	COG2828	Protein conserved in bacteria
A1S_2762	COG1113	amino acid transport
A1S_2763	COG1113	amino acid transport
A1S_2767	COG2207	Transcriptional regulator
A1S_2772	COG2249	NAD(P)H dehydrogenase (quinone) activity
A1S_2776	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A1S_2777	COG1530	ribonuclease E activity
A1S_2778	COG0424	maF-like protein
A1S_2779	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A1S_2780	COG1792	Involved in formation and maintenance of cell shape
A1S_2781	COG1077	Cell shape determining protein MreB Mrl
A1S_2782	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A1S_2784	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A1S_2789	COG3590	peptidase
A1S_2790	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A1S_2791	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A1S_2792	COG1752	Esterase of the alpha-beta hydrolase superfamily
A1S_2793	COG1115	amino acid carrier protein
A1S_2795	COG2814	Major facilitator Superfamily
A1S_2796	COG1289	transmembrane transporter activity
A1S_2806	COG1376	ErfK ybiS ycfS ynhG family protein
A1S_2807	COG2832	Protein of unknown function (DUF454)
A1S_2809	COG5510	response to toxic substance
A1S_2812	COG0840	transmembrane signaling receptor activity
A1S_2820	COG3422	double-strand break repair
A1S_2821	COG2824	Alkylphosphonate utilization operon protein PhnA
A1S_2822	COG3189	MarR family transcriptional regulator
A1S_2824	COG0354	folic acid binding
A1S_2825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A1S_2827	COG0679	Auxin Efflux Carrier
A1S_2828	COG1902	pentaerythritol trinitrate reductase activity
A1S_2829	COG4772	TonB-dependent receptor
A1S_2830	COG2094	Belongs to the DNA glycosylase MPG family
A1S_2836	COG2233	PERMEase
A1S_2838	COG0833	amino acid
A1S_2839	COG1690	Belongs to the RtcB family
A1S_2842	COG0183	Belongs to the thiolase family
A1S_2846	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A1S_2851	COG2207	Transcriptional regulator
A1S_2852	COG0183	Belongs to the thiolase family
A1S_2853	COG1024	Enoyl-CoA hydratase
A1S_2853	COG1250	3-hydroxyacyl-CoA dehydrogenase
A1S_2854	COG1024	Enoyl-CoA hydratase
A1S_2854	COG1250	3-hydroxyacyl-CoA dehydrogenase
A1S_2857	COG2153	protein acetylation
A1S_2859	COG1272	protein, Hemolysin III
A1S_2860	COG0477	Major facilitator Superfamily
A1S_2863	COG0450	alkyl hydroperoxide reductase
A1S_2868	COG0285	dihydrofolate synthase activity
A1S_2875	COG0133	tryptophan synthase activity
A1S_2877	COG4206	TonB-dependent receptor
A1S_2878	COG2096	Adenosyltransferase
A1S_2882	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A1S_2883	COG0745	RESPONSE REGULATOR receiver
A1S_2884	COG2205	protein histidine kinase activity
A1S_2886	COG1960	acyl-CoA dehydrogenase activity
A1S_2887	COG1960	acyl-CoA dehydrogenase activity
A1S_2897	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A1S_2899	COG0438	transferase activity, transferring glycosyl groups
A1S_2900	COG0463	Glycosyl transferase, family 2
A1S_2901	COG0726	polysaccharide deacetylase
A1S_2905	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A1S_2906	COG2205	protein histidine kinase activity
A1S_2907	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A1S_2908	COG0582	viral genome integration into host DNA
A1S_2913	COG1862	Preprotein translocase
A1S_2917	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A1S_2919	COG3781	membrane
A1S_2920	COG0613	PHP domain protein
A1S_2922	COG2350	Protein conserved in bacteria
A1S_2927	COG0582	viral genome integration into host DNA
A1S_2932	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1S_2936	COG2132	Multicopper oxidase
A1S_2938	COG2205	protein histidine kinase activity
A1S_2947	COG1607	acyl-coa hydrolase
A1S_2951	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A1S_2951	COG3453	Protein conserved in bacteria
A1S_2955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A1S_2958	COG0583	DNA-binding transcription factor activity
A1S_2962	COG2951	lytic endotransglycosylase activity
A1S_2963	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A1S_2966	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A1S_2968	COG0671	phosphoesterase, PA-phosphatase related
A1S_2969	COG0861	Integral membrane protein TerC family
A1S_2970	COG0754	glutathionylspermidine amidase activity
A1S_2972	COG0402	S-adenosylhomocysteine deaminase activity
A1S_2973	COG0402	S-adenosylhomocysteine deaminase activity
A1S_2976	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A1S_2977	COG1230	cation diffusion facilitator family transporter
A1S_2980	COG0706	membrane insertase activity
A1S_2981	COG0706	membrane insertase activity
A1S_2984	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A1S_2986	COG2199	diguanylate cyclase activity
A1S_2988	COG1408	metallophosphoesterase
A1S_2989	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A1S_2991	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A1S_2997	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A1S_2998	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A1S_2999	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A1S_3001	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A1S_3003	COG2969	positive regulation of protein catabolic process
A1S_3007	COG1960	acyl-CoA dehydrogenase activity
A1S_3008	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A1S_3011	COG1309	transcriptional regulator
A1S_3012	COG1960	acyl-CoA dehydrogenase activity
A1S_3017	COG1183	phosphatidylcholine synthase activity
A1S_3021	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A1S_3027	COG1196	nuclear chromosome segregation
A1S_3027	COG0741	lytic transglycosylase activity
A1S_3027	COG0739	heme binding
A1S_3030	COG1702	phosphate starvation-inducible protein PhoH
A1S_3037	COG1295	ribonuclease BN
A1S_3038	COG0697	spore germination
A1S_3039	COG2169	Transcriptional regulator
A1S_3040	COG0179	Fumarylacetoacetate (FAA) hydrolase
A1S_3045	COG0557	exoribonuclease II activity
A1S_3047	COG0339	signal peptide processing
A1S_3048	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
A1S_3052	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
A1S_3053	COG1960	acyl-CoA dehydrogenase activity
A1S_3058	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A1S_3060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A1S_3083	COG0626	cystathionine gamma-synthase activity
A1S_3084	COG0433	COG0433 Predicted ATPase
A1S_3085	COG1017	nitric oxide dioxygenase activity
A1S_3085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A1S_3086	COG1959	2 iron, 2 sulfur cluster binding
A1S_3089	COG1301	dicarboxylic acid transport
A1S_3090	COG1946	Acyl-CoA thioesterase
A1S_3095	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A1S_3096	COG1040	competence protein
A1S_3098	COG0598	Magnesium transport protein CorA
A1S_3100	COG2854	intermembrane phospholipid transfer
A1S_3102	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A1S_3103	COG1127	ABC transporter
A1S_3104	COG0513	Belongs to the DEAD box helicase family
A1S_3108	COG0408	coproporphyrinogen oxidase activity
A1S_3111	COG1960	acyl-CoA dehydrogenase activity
A1S_3113	COG1983	PspC domain protein
A1S_3114	COG0517	IMP dehydrogenase activity
A1S_3123	COG0583	DNA-binding transcription factor activity
A1S_3130	COG1012	belongs to the aldehyde dehydrogenase family
A1S_3132	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A1S_3134	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A1S_3135	COG0833	amino acid
A1S_3142	COG0628	permease
A1S_3144	COG1289	transmembrane transporter activity
A1S_3145	COG1289	transmembrane transporter activity
A1S_3148	COG2249	NAD(P)H dehydrogenase (quinone) activity
A1S_3149	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A1S_3151	COG0277	FAD linked oxidase domain protein
A1S_3152	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A1S_3158	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A1S_3159	COG5380	lipid catabolic process
A1S_3163	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A1S_3170	COG0194	GDP metabolic process
A1S_3172	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1S_3176	COG3307	-O-antigen
A1S_3179	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A1S_3180	COG1704	LemA family
A1S_3182	COG0493	'glutamate synthase
A1S_3185	COG0069	glutamate synthase activity
A1S_3185	COG0070	glutamate synthase
A1S_3185	COG0067	glutamate synthase
A1S_3198	COG2226	methyltransferase
A1S_3202	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A1S_3203	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A1S_3211	COG0833	amino acid
A1S_3221	COG0488	(ABC) transporter
A1S_3224	COG4221	oxidoreductase activity
A1S_3225	COG0659	secondary active sulfate transmembrane transporter activity
A1S_3227	COG2183	response to ionizing radiation
A1S_3229	COG0745	RESPONSE REGULATOR receiver
A1S_3231	COG0427	acetyl-CoA hydrolase
A1S_3235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A1S_3241	COG2329	Antibiotic biosynthesis monooxygenase
A1S_3244	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A1S_3255	COG2207	Transcriptional regulator
A1S_3256	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
A1S_3258	COG2249	NAD(P)H dehydrogenase (quinone) activity
A1S_3259	COG1733	regulation of RNA biosynthetic process
A1S_3262	COG1733	regulation of RNA biosynthetic process
A1S_3266	COG0667	Aldo Keto reductase
A1S_3271	COG0583	DNA-binding transcription factor activity
A1S_3272	COG2814	Major facilitator Superfamily
A1S_3278	COG1335	isochorismatase
A1S_3280	COG1012	belongs to the aldehyde dehydrogenase family
A1S_3281	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A1S_3283	COG1113	amino acid transport
A1S_3285	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A1S_3288	COG2814	Major facilitator Superfamily
A1S_3290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A1S_3290	COG0351	phosphomethylpyrimidine kinase
A1S_3290	COG0352	thiamine-phosphate diphosphorylase activity
A1S_3294	COG1309	transcriptional regulator
A1S_3295	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A1S_3296	COG3706	GGDEF domain
A1S_3298	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A1S_3300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A1S_3301	COG3162	membrane
A1S_3302	COG2205	protein histidine kinase activity
A1S_3302	COG0784	Response regulator, receiver
A1S_3302	COG2198	Histidine kinase
A1S_3307	COG1522	sequence-specific DNA binding
A1S_3308	COG1335	isochorismatase
A1S_3309	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A1S_3311	COG0668	transmembrane transport
A1S_3313	COG1519	Transferase
A1S_3314	COG1902	pentaerythritol trinitrate reductase activity
A1S_3318	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A1S_3323	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A1S_3323	COG0426	domain, Protein
A1S_3324	COG4774	siderophore transport
A1S_3326	COG2119	membrane
A1S_3327	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1S_3329	COG4942	peptidase
A1S_3331	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A1S_3333	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A1S_3337	COG0189	ligase activity
A1S_3341	COG0708	Exodeoxyribonuclease III
A1S_3342	COG1393	Belongs to the ArsC family
A1S_3345	COG3706	GGDEF domain
A1S_3353	COG2351	hydroxyisourate hydrolase activity
A1S_3354	COG2233	PERMEase
A1S_3356	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1S_3358	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A1S_3360	COG3150	esterase
A1S_3363	COG0791	NLP P60 protein
A1S_3363	COG1388	LysM domain
A1S_3364	COG3501	Rhs element vgr protein
A1S_3366	COG2918	glutathione biosynthetic process
A1S_3369	COG2733	membrane
A1S_3370	COG0436	Aminotransferase
A1S_3371	COG0534	Mate efflux family protein
A1S_3375	COG0745	RESPONSE REGULATOR receiver
A1S_3382	COG0753	catalase activity
A1S_3386	COG3830	Belongs to the UPF0237 family
A1S_3386	COG0560	Phosphoserine phosphatase
A1S_3391	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A1S_3392	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A1S_3395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A1S_3396	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A1S_3397	COG1280	lysine exporter protein (LysE YggA)
A1S_3402	COG0010	Belongs to the arginase family
A1S_3409	COG2188	Transcriptional regulator
A1S_3411	COG0523	cobalamin synthesis protein
A1S_3413	COG1113	amino acid transport
A1S_3415	COG0625	glutathione transferase activity
A1S_3419	COG1683	Conserved Protein
A1S_3420	COG0534	Mate efflux family protein
A1S_3421	COG0385	Bile acid
A1S_3422	COG1335	isochorismatase
A1S_3423	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A1S_3426	COG2116	formate transmembrane transporter activity
A1S_3427	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A1S_3428	COG2133	pyrroloquinoline quinone binding
A1S_3429	COG2983	Belongs to the UPF0260 family
A1S_3432	COG1194	a g-specific adenine glycosylase
A1S_3435	COG2818	Glycosylase
A1S_3436	COG1064	alcohol dehydrogenase
A1S_3437	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A1S_3438	COG0583	DNA-binding transcription factor activity
A1S_3439	COG0656	L-ascorbic acid biosynthetic process
A1S_3440	COG2814	Major facilitator Superfamily
A1S_3446	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1S_3447	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A1S_3450	COG2233	PERMEase
A1S_3451	COG2233	PERMEase
A1S_3458	COG0733	neurotransmitter:sodium symporter activity
A1S_3462	COG0583	DNA-binding transcription factor activity
A1S_3463	COG0019	diaminopimelate decarboxylase activity
A1S_3469	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
A1S_3474	COG1028	Short-chain dehydrogenase reductase Sdr
A1S_3589	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A1S_3665	COG0625	glutathione transferase activity
A1S_3721	COG1309	transcriptional regulator
A1S_3785	COG1923	regulation of RNA biosynthetic process
A1S_3792	COG3658	cytochrome
A1S_3805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A1S_3809	COG1113	amino acid transport
A1S_3858	COG3013	Belongs to the UPF0304 family
A1S_3868	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1S_3868	COG5549	protein import