locus-tag	class	description
GO593_00025	COG3111	PFAM Bacterial OB fold (BOF) protein
GO593_00120	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GO593_00125	COG1610	YqeY-like protein
GO593_00130	COG4783	chaperone-mediated protein folding
GO593_00155	COG1286	toxin biosynthetic process
GO593_00185	COG0778	Nitroreductase
GO593_00195	COG0513	Belongs to the DEAD box helicase family
GO593_00215	COG2363	Small membrane protein
GO593_00245	COG1234	tRNA 3'-trailer cleavage
GO593_00250	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO593_00260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO593_00270	COG2819	hydrolase of the alpha beta superfamily
GO593_00275	COG1960	acyl-CoA dehydrogenase activity
GO593_00280	COG1301	dicarboxylic acid transport
GO593_00285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO593_00290	COG3139	Protein of unknown function (DUF1315)
GO593_00295	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO593_00300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO593_00310	COG0494	nUDIX hydrolase
GO593_00320	COG0642	Histidine kinase
GO593_00325	COG0745	RESPONSE REGULATOR receiver
GO593_00330	COG3111	PFAM Bacterial OB fold (BOF) protein
GO593_00345	COG1720	tRNA m6t6A37 methyltransferase activity
GO593_00360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO593_00370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO593_00380	COG4598	ABC transporter
GO593_00385	COG4160	amino acid transport
GO593_00390	COG4215	(ABC) transporter
GO593_00405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO593_00415	COG1538	Outer membrane efflux protein
GO593_00765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO593_00795	COG3617	BRO family, N-terminal domain
GO593_00800	COG0582	viral genome integration into host DNA
GO593_00805	COG1131	(ABC) transporter
GO593_00810	COG0842	Transport permease protein
GO593_00825	COG0772	Belongs to the SEDS family
GO593_00830	COG2951	lytic endotransglycosylase activity
GO593_00855	COG2207	Transcriptional regulator
GO593_00870	COG0052	Belongs to the universal ribosomal protein uS2 family
GO593_00875	COG0024	Methionine aminopeptidase
GO593_00885	COG2223	nitrite transmembrane transporter activity
GO593_00895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO593_00900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO593_00905	COG1960	acyl-CoA dehydrogenase activity
GO593_00920	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GO593_00925	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GO593_00930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO593_00950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO593_00955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO593_00960	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO593_00995	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
GO593_01020	COG0512	Glutamine amidotransferase of anthranilate synthase
GO593_01025	COG0308	aminopeptidase N
GO593_01055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GO593_01085	COG3739	integral membrane protein
GO593_01100	COG1169	isochorismate synthase
GO593_01110	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GO593_01115	COG5265	(ABC) transporter
GO593_01120	COG1132	(ABC) transporter
GO593_01135	COG3433	isochorismatase activity
GO593_01135	COG1535	isochorismatase
GO593_01140	COG1021	2,3-dihydroxybenzoate-AMP ligase
GO593_01145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO593_01155	COG4774	siderophore transport
GO593_01160	COG4607	ABC-type enterochelin transport system periplasmic component
GO593_01165	COG4604	ABC transporter, ATP-binding protein
GO593_01170	COG4605	iron ion homeostasis
GO593_01175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO593_01180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO593_01195	COG2964	Protein conserved in bacteria
GO593_01205	COG1741	Belongs to the pirin family
GO593_01235	COG2879	small protein
GO593_01240	COG1966	Carbon starvation protein
GO593_01260	COG4943	cyclic-guanylate-specific phosphodiesterase activity
GO593_01285	COG1067	ATP-dependent peptidase activity
GO593_01290	COG0583	DNA-binding transcription factor activity
GO593_01315	COG1686	Belongs to the peptidase S11 family
GO593_01320	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GO593_01355	COG0616	signal peptide processing
GO593_01360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO593_01370	COG0573	inorganic phosphate transmembrane transporter activity
GO593_01375	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO593_01380	COG1113	amino acid transport
GO593_01385	COG3961	Belongs to the TPP enzyme family
GO593_01390	COG1522	sequence-specific DNA binding
GO593_01400	COG0076	glutamate decarboxylase activity
GO593_01405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO593_01420	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO593_01430	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO593_01465	COG0352	thiamine-phosphate diphosphorylase activity
GO593_01490	COG0612	Peptidase, M16
GO593_01505	COG0583	DNA-binding transcription factor activity
GO593_01510	COG0477	Major facilitator Superfamily
GO593_01535	COG1187	pseudouridine synthase activity
GO593_01550	COG1686	Belongs to the peptidase S11 family
GO593_01555	COG1252	NADH dehydrogenase
GO593_01565	COG0415	Belongs to the DNA photolyase family
GO593_01580	COG1215	transferase activity, transferring glycosyl groups
GO593_01610	COG2070	2-Nitropropane dioxygenase
GO593_01665	COG0556	nucleotide-excision repair
GO593_01695	COG0443	Heat shock 70 kDa protein
GO593_01725	COG4221	oxidoreductase activity
GO593_01735	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GO593_01740	COG1381	Involved in DNA repair and RecF pathway recombination
GO593_01750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GO593_01765	COG0681	Belongs to the peptidase S26 family
GO593_01780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO593_01800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO593_01805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO593_01810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
GO593_01820	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
GO593_01825	COG4208	sulfate ABC transporter
GO593_01830	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GO593_01835	COG0583	DNA-binding transcription factor activity
GO593_01840	COG4625	pathogenesis
GO593_01855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GO593_01870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO593_01880	COG1056	cytidyltransferase-related domain
GO593_01880	COG1051	belongs to the nudix hydrolase family
GO593_01885	COG1024	Enoyl-CoA hydratase
GO593_01890	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO593_01895	COG2814	Major facilitator Superfamily
GO593_01900	COG0047	phosphoribosylformylglycinamidine synthase activity
GO593_01900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO593_01920	COG1473	amidohydrolase
GO593_01925	COG0824	Thioesterase
GO593_01945	COG0823	Involved in the tonB-independent uptake of proteins
GO593_01965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO593_02000	COG0628	permease
GO593_02010	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO593_02015	COG0596	Alpha beta hydrolase
GO593_02020	COG0616	signal peptide processing
GO593_02020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GO593_02030	COG2333	competence protein COMEC
GO593_02030	COG0658	competence protein
GO593_02035	COG1136	(ABC) transporter
GO593_02040	COG4591	ABC-type transport system involved in lipoprotein release permease component
GO593_02070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO593_02090	COG0463	Glycosyl transferase, family 2
GO593_02120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
GO593_02125	COG1280	lysine exporter protein (LysE YggA)
GO593_02130	COG2267	carboxylic ester hydrolase activity
GO593_02145	COG0019	diaminopimelate decarboxylase activity
GO593_02155	COG1113	amino acid transport
GO593_02170	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GO593_02180	COG3339	Conserved Protein
GO593_02185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO593_02190	COG0243	molybdopterin cofactor binding
GO593_02195	COG1929	Belongs to the glycerate kinase type-1 family
GO593_02210	COG0778	Nitroreductase
GO593_02235	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO593_02250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO593_02270	COG0741	lytic transglycosylase activity
GO593_02290	COG0584	glycerophosphoryl diester phosphodiesterase
GO593_02295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO593_02320	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GO593_02340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO593_02345	COG0477	Major facilitator Superfamily
GO593_02395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO593_02400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO593_02425	COG0505	Belongs to the CarA family
GO593_02445	COG0589	response to stress
GO593_02460	COG2843	Capsule synthesis protein
GO593_02480	COG2321	neutral zinc metallopeptidase
GO593_02485	COG2354	Protein conserved in bacteria
GO593_02505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO593_02530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GO593_02535	COG1053	succinate dehydrogenase
GO593_02540	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
GO593_02545	COG2009	succinate dehydrogenase
GO593_02585	COG2921	Belongs to the UPF0250 family
GO593_02590	COG0321	lipoyl(octanoyl) transferase activity
GO593_02605	COG0531	amino acid
GO593_02620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO593_02625	COG1648	precorrin-2 dehydrogenase activity
GO593_02625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO593_02640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GO593_02670	COG0671	phosphoesterase, PA-phosphatase related
GO593_02675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO593_02685	COG1538	Outer membrane efflux protein
GO593_02690	COG0393	Putative heavy-metal-binding
GO593_02695	COG0393	Putative heavy-metal-binding
GO593_02705	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_02715	COG0525	valine-tRNA ligase activity
GO593_02735	COG0583	DNA-binding transcription factor activity
GO593_02740	COG0004	ammonium transporteR
GO593_02755	COG0642	Histidine kinase
GO593_02760	COG0745	RESPONSE REGULATOR receiver
GO593_02765	COG2194	sulfuric ester hydrolase activity
GO593_02785	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO593_02800	COG2315	Protein conserved in bacteria
GO593_02805	COG0142	geranyltranstransferase activity
GO593_02810	COG2828	Protein conserved in bacteria
GO593_02815	COG1113	amino acid transport
GO593_02835	COG2207	Transcriptional regulator
GO593_02860	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO593_02880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO593_02890	COG1530	ribonuclease E activity
GO593_02895	COG0424	maF-like protein
GO593_02900	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GO593_02905	COG1792	Involved in formation and maintenance of cell shape
GO593_02910	COG1077	Cell shape determining protein MreB Mrl
GO593_02915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GO593_02925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GO593_02950	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
GO593_02955	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GO593_02960	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO593_02965	COG1115	amino acid carrier protein
GO593_02985	COG2814	Major facilitator Superfamily
GO593_02990	COG1289	transmembrane transporter activity
GO593_03040	COG1376	ErfK ybiS ycfS ynhG family protein
GO593_03045	COG2832	Protein of unknown function (DUF454)
GO593_03055	COG5510	response to toxic substance
GO593_03075	COG0840	transmembrane signaling receptor activity
GO593_03115	COG3422	double-strand break repair
GO593_03120	COG2824	Alkylphosphonate utilization operon protein PhnA
GO593_03125	COG3189	MarR family transcriptional regulator
GO593_03135	COG0354	folic acid binding
GO593_03140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO593_03150	COG0679	Auxin Efflux Carrier
GO593_03155	COG1902	pentaerythritol trinitrate reductase activity
GO593_03160	COG4772	TonB-dependent receptor
GO593_03165	COG2094	Belongs to the DNA glycosylase MPG family
GO593_03195	COG2233	PERMEase
GO593_03205	COG0833	amino acid
GO593_03210	COG1690	Belongs to the RtcB family
GO593_03215	COG2885	chlorophyll binding
GO593_03215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GO593_03225	COG0183	Belongs to the thiolase family
GO593_03245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO593_03265	COG2207	Transcriptional regulator
GO593_03270	COG0183	Belongs to the thiolase family
GO593_03300	COG1272	protein, Hemolysin III
GO593_03305	COG0477	Major facilitator Superfamily
GO593_03320	COG0450	alkyl hydroperoxide reductase
GO593_03340	COG0285	dihydrofolate synthase activity
GO593_03375	COG0133	tryptophan synthase activity
GO593_03385	COG4206	TonB-dependent receptor
GO593_03390	COG2096	Adenosyltransferase
GO593_03410	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
GO593_03415	COG0745	RESPONSE REGULATOR receiver
GO593_03420	COG2205	protein histidine kinase activity
GO593_03430	COG1960	acyl-CoA dehydrogenase activity
GO593_03435	COG1960	acyl-CoA dehydrogenase activity
GO593_03440	COG0583	DNA-binding transcription factor activity
GO593_03445	COG0625	glutathione transferase activity
GO593_03510	COG0438	transferase activity, transferring glycosyl groups
GO593_03515	COG0463	Glycosyl transferase, family 2
GO593_03520	COG0726	polysaccharide deacetylase
GO593_03540	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GO593_03545	COG2205	protein histidine kinase activity
GO593_03580	COG1862	Preprotein translocase
GO593_03590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO593_03595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO593_03605	COG3781	membrane
GO593_03610	COG0613	PHP domain protein
GO593_03620	COG2350	Protein conserved in bacteria
GO593_03650	COG1607	acyl-coa hydrolase
GO593_03665	COG3453	Protein conserved in bacteria
GO593_03665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO593_03710	COG2199	diguanylate cyclase activity
GO593_03720	COG1408	metallophosphoesterase
GO593_03725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO593_03735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO593_03755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO593_03760	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GO593_03775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO593_03785	COG2969	positive regulation of protein catabolic process
GO593_03805	COG1960	acyl-CoA dehydrogenase activity
GO593_03810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO593_03825	COG1309	transcriptional regulator
GO593_03830	COG1960	acyl-CoA dehydrogenase activity
GO593_03875	COG1183	phosphatidylcholine synthase activity
GO593_03880	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GO593_03910	COG0741	lytic transglycosylase activity
GO593_03910	COG1196	nuclear chromosome segregation
GO593_03910	COG0739	heme binding
GO593_03920	COG1702	phosphate starvation-inducible protein PhoH
GO593_03955	COG1295	ribonuclease BN
GO593_03960	COG0697	spore germination
GO593_03965	COG2169	Transcriptional regulator
GO593_03970	COG0179	Fumarylacetoacetate (FAA) hydrolase
GO593_04015	COG0557	exoribonuclease II activity
GO593_04020	COG0339	signal peptide processing
GO593_04025	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
GO593_04055	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GO593_04060	COG1960	acyl-CoA dehydrogenase activity
GO593_04085	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GO593_04095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO593_04215	COG0626	cystathionine gamma-synthase activity
GO593_04220	COG0433	COG0433 Predicted ATPase
GO593_04225	COG1017	nitric oxide dioxygenase activity
GO593_04225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO593_04230	COG1959	2 iron, 2 sulfur cluster binding
GO593_04245	COG1301	dicarboxylic acid transport
GO593_04250	COG1946	Acyl-CoA thioesterase
GO593_04270	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GO593_04275	COG1040	competence protein
GO593_04280	COG0494	nUDIX hydrolase
GO593_04290	COG0598	Magnesium transport protein CorA
GO593_04300	COG2854	intermembrane phospholipid transfer
GO593_04310	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GO593_04315	COG1127	ABC transporter
GO593_04325	COG0513	Belongs to the DEAD box helicase family
GO593_04345	COG0408	coproporphyrinogen oxidase activity
GO593_04360	COG1960	acyl-CoA dehydrogenase activity
GO593_04370	COG1983	PspC domain protein
GO593_04375	COG0517	IMP dehydrogenase activity
GO593_04415	COG0583	DNA-binding transcription factor activity
GO593_04455	COG1012	belongs to the aldehyde dehydrogenase family
GO593_04465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO593_04470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO593_04475	COG0833	amino acid
GO593_04505	COG1192	Involved in chromosome partitioning
GO593_04510	COG0628	permease
GO593_04520	COG1289	transmembrane transporter activity
GO593_04535	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO593_04540	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO593_04550	COG0277	FAD linked oxidase domain protein
GO593_04555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO593_04580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO593_04585	COG5380	lipid catabolic process
GO593_04605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GO593_04655	COG0194	GDP metabolic process
GO593_04670	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO593_04690	COG3307	-O-antigen
GO593_04710	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GO593_04715	COG1704	LemA family
GO593_04725	COG0493	'glutamate synthase
GO593_04730	COG0069	glutamate synthase activity
GO593_04730	COG0070	glutamate synthase
GO593_04730	COG0067	glutamate synthase
GO593_04780	COG2226	methyltransferase
GO593_04795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO593_04800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GO593_04845	COG0833	amino acid
GO593_04910	COG0488	(ABC) transporter
GO593_04920	COG4221	oxidoreductase activity
GO593_04925	COG0659	secondary active sulfate transmembrane transporter activity
GO593_04935	COG0745	RESPONSE REGULATOR receiver
GO593_04950	COG0427	acetyl-CoA hydrolase
GO593_04980	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO593_05020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO593_05090	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO593_05095	COG1733	regulation of RNA biosynthetic process
GO593_05125	COG0667	Aldo Keto reductase
GO593_05145	COG0583	DNA-binding transcription factor activity
GO593_05150	COG2814	Major facilitator Superfamily
GO593_05180	COG1335	isochorismatase
GO593_05190	COG1012	belongs to the aldehyde dehydrogenase family
GO593_05195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO593_05205	COG1113	amino acid transport
GO593_05215	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GO593_05265	COG2814	Major facilitator Superfamily
GO593_05275	COG0351	phosphomethylpyrimidine kinase
GO593_05275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GO593_05275	COG0352	thiamine-phosphate diphosphorylase activity
GO593_05295	COG1309	transcriptional regulator
GO593_05300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GO593_05305	COG3706	GGDEF domain
GO593_05315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO593_05325	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO593_05330	COG3162	membrane
GO593_05335	COG2205	protein histidine kinase activity
GO593_05335	COG2198	Histidine kinase
GO593_05335	COG0784	Response regulator, receiver
GO593_05360	COG1522	sequence-specific DNA binding
GO593_05365	COG1335	isochorismatase
GO593_05370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO593_05380	COG0668	transmembrane transport
GO593_05385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO593_05390	COG1519	Transferase
GO593_05395	COG1902	pentaerythritol trinitrate reductase activity
GO593_05415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO593_05440	COG0426	domain, Protein
GO593_05440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO593_05445	COG4774	siderophore transport
GO593_05450	COG2119	membrane
GO593_05460	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO593_05470	COG4942	peptidase
GO593_05485	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GO593_05495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO593_05515	COG0189	ligase activity
GO593_05535	COG0708	Exodeoxyribonuclease III
GO593_05540	COG1393	Belongs to the ArsC family
GO593_05555	COG3706	GGDEF domain
GO593_05590	COG2351	hydroxyisourate hydrolase activity
GO593_05595	COG2233	PERMEase
GO593_05605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO593_05615	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GO593_05620	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_05630	COG3150	esterase
GO593_05645	COG3179	chitinase
GO593_05660	COG2918	glutathione biosynthetic process
GO593_05675	COG2733	membrane
GO593_05680	COG0436	Aminotransferase
GO593_05685	COG0534	Mate efflux family protein
GO593_05735	COG0753	catalase activity
GO593_05780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GO593_05785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO593_05795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO593_05800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO593_05805	COG0546	phosphoglycolate phosphatase activity
GO593_05815	COG0010	Belongs to the arginase family
GO593_05845	COG2188	Transcriptional regulator
GO593_05855	COG0523	cobalamin synthesis protein
GO593_05865	COG1113	amino acid transport
GO593_05875	COG0625	glutathione transferase activity
GO593_05895	COG1683	Conserved Protein
GO593_05905	COG0385	Bile acid
GO593_05910	COG1335	isochorismatase
GO593_05915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO593_05935	COG2116	formate transmembrane transporter activity
GO593_05940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO593_05945	COG2133	pyrroloquinoline quinone binding
GO593_05950	COG2983	Belongs to the UPF0260 family
GO593_05970	COG1194	a g-specific adenine glycosylase
GO593_05985	COG2818	Glycosylase
GO593_05990	COG1064	alcohol dehydrogenase
GO593_05995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO593_06010	COG0583	DNA-binding transcription factor activity
GO593_06015	COG0656	L-ascorbic acid biosynthetic process
GO593_06020	COG2814	Major facilitator Superfamily
GO593_06055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO593_06070	COG2233	PERMEase
GO593_06075	COG0583	DNA-binding transcription factor activity
GO593_06110	COG0733	neurotransmitter:sodium symporter activity
GO593_06120	COG0625	glutathione transferase activity
GO593_06155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO593_06160	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GO593_06165	COG0596	Alpha beta hydrolase
GO593_06190	COG0488	(ABC) transporter
GO593_06195	COG0586	Pfam SNARE associated Golgi protein
GO593_06205	COG0187	DNA topoisomerase II activity
GO593_06215	COG0592	DNA-directed DNA polymerase activity
GO593_06225	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GO593_06240	COG0706	membrane insertase activity
GO593_06255	COG1230	cation diffusion facilitator family transporter
GO593_06260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO593_06275	COG0402	S-adenosylhomocysteine deaminase activity
GO593_06285	COG0754	glutathionylspermidine amidase activity
GO593_06295	COG0861	Integral membrane protein TerC family
GO593_06300	COG0671	phosphoesterase, PA-phosphatase related
GO593_06310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO593_06325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO593_06330	COG2951	lytic endotransglycosylase activity
GO593_06385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO593_06425	COG1047	Peptidyl-prolyl cis-trans
GO593_06435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO593_06440	COG0196	riboflavin kinase activity
GO593_06450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO593_06455	COG1309	transcriptional regulator
GO593_06460	COG1116	anion transmembrane transporter activity
GO593_06465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO593_06470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO593_06475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO593_06480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO593_06500	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_06505	COG0546	phosphoglycolate phosphatase activity
GO593_06600	COG4691	Plasmid stability protein
GO593_06635	COG0798	PFAM Bile acid sodium symporter
GO593_06675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO593_06700	COG2184	nucleotidyltransferase activity
GO593_06810	COG3023	N-Acetylmuramoyl-L-alanine amidase
GO593_06815	COG0728	peptidoglycan biosynthetic process
GO593_06840	COG1596	polysaccharide export
GO593_06845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GO593_06875	COG0438	transferase activity, transferring glycosyl groups
GO593_06900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO593_06905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO593_06920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO593_06925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO593_06945	COG0277	FAD linked oxidase domain protein
GO593_06950	COG1448	Aminotransferase
GO593_06955	COG1802	Transcriptional regulator
GO593_06970	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GO593_07055	COG0564	pseudouridine synthase activity
GO593_07080	COG1522	sequence-specific DNA binding
GO593_07095	COG0251	oxidation-reduction process
GO593_07100	COG1113	amino acid transport
GO593_07105	COG1113	amino acid transport
GO593_07125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO593_07130	COG1960	acyl-CoA dehydrogenase activity
GO593_07135	COG1024	Enoyl-CoA hydratase
GO593_07140	COG1024	Enoyl-CoA hydratase
GO593_07145	COG0477	Major facilitator Superfamily
GO593_07150	COG3916	Acyl-homoserine-lactone synthase
GO593_07160	COG2197	response regulator
GO593_07170	COG1960	acyl-CoA dehydrogenase activity
GO593_07175	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GO593_07175	COG3321	synthase
GO593_07175	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO593_07175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO593_07195	COG2267	carboxylic ester hydrolase activity
GO593_07215	COG0271	Belongs to the BolA IbaG family
GO593_07225	COG1192	Involved in chromosome partitioning
GO593_07240	COG0586	Pfam SNARE associated Golgi protein
GO593_07245	COG2259	Doxx family
GO593_07250	COG4399	Belongs to the UPF0754 family
GO593_07255	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO593_07255	COG0519	Catalyzes the synthesis of GMP from XMP
GO593_07300	COG0281	malic enzyme
GO593_07305	COG2837	iron assimilation
GO593_07310	COG1280	lysine exporter protein (LysE YggA)
GO593_07315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO593_07320	COG1121	(ABC) transporter
GO593_07385	COG0386	Belongs to the glutathione peroxidase family
GO593_07400	COG1309	transcriptional regulator
GO593_07405	COG0697	spore germination
GO593_07415	COG0758	DNA mediated transformation
GO593_07450	COG1309	transcriptional regulator
GO593_07485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO593_07495	COG0655	NAD(P)H dehydrogenase (quinone) activity
GO593_07530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO593_07540	COG2814	Major facilitator Superfamily
GO593_07550	COG1253	flavin adenine dinucleotide binding
GO593_07560	COG2860	membrane
GO593_07565	COG0477	Major facilitator Superfamily
GO593_07575	COG0318	PFAM AMP-dependent synthetase and ligase
GO593_07590	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GO593_07605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO593_07615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO593_07620	COG0606	chelatase, subunit chli
GO593_07630	COG0347	Belongs to the P(II) protein family
GO593_07635	COG0004	ammonium transporteR
GO593_07645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO593_07645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO593_07685	COG0795	lipopolysaccharide-transporting ATPase activity
GO593_07690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GO593_07695	COG0793	Belongs to the peptidase S41A family
GO593_07710	COG2197	response regulator
GO593_07720	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GO593_07730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO593_07735	COG4974	Belongs to the 'phage' integrase family
GO593_07760	COG0772	Belongs to the SEDS family
GO593_07765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO593_07770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO593_07775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GO593_07800	COG0697	spore germination
GO593_07805	COG1538	Outer membrane efflux protein
GO593_07825	COG3275	phosphorelay sensor kinase activity
GO593_07835	COG0181	hydroxymethylbilane synthase activity
GO593_07880	COG1716	ATPase activity
GO593_07885	COG0546	phosphoglycolate phosphatase activity
GO593_07985	COG2056	Na+-H+ antiporter family
GO593_08000	COG0326	Molecular chaperone. Has ATPase activity
GO593_08015	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GO593_08075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO593_08080	COG2169	Transcriptional regulator
GO593_08080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO593_08110	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GO593_08120	COG0497	DNA recombination
GO593_08135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO593_08145	COG0237	dephospho-CoA kinase activity
GO593_08190	COG0195	Participates in both transcription termination and antitermination
GO593_08210	COG2212	antiporter activity
GO593_08220	COG0651	ATP synthesis coupled electron transport
GO593_08225	COG1006	Multisubunit Na H antiporter MnhC subunit
GO593_08230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO593_08230	COG2111	Na H antiporter
GO593_08245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO593_08250	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO593_08265	COG2226	methyltransferase
GO593_08285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
GO593_08290	COG1074	ATP-dependent DNA helicase activity
GO593_08295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO593_08315	COG0598	Magnesium transport protein CorA
GO593_08320	COG0789	Transcriptional regulator
GO593_08325	COG0484	heat shock protein binding
GO593_08340	COG0475	glutathione-regulated potassium exporter activity
GO593_08340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO593_08345	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO593_08365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO593_08375	COG4535	Mg2 and Co2 transporter CorC
GO593_08380	COG0425	Belongs to the sulfur carrier protein TusA family
GO593_08385	COG0644	oxidoreductase
GO593_08385	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
GO593_08395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO593_08410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO593_08415	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GO593_08450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GO593_08465	COG0534	Mate efflux family protein
GO593_08475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO593_08480	COG4221	oxidoreductase activity
GO593_08485	COG0583	DNA-binding transcription factor activity
GO593_08505	COG1530	ribonuclease E activity
GO593_08515	COG0546	phosphoglycolate phosphatase activity
GO593_08520	COG2378	regulation of single-species biofilm formation
GO593_08525	COG0625	glutathione transferase activity
GO593_08535	COG0583	DNA-binding transcription factor activity
GO593_08600	COG0473	3-isopropylmalate dehydrogenase activity
GO593_08655	COG1301	dicarboxylic acid transport
GO593_08665	COG1560	Kdo2-lipid A biosynthetic process
GO593_08670	COG1280	lysine exporter protein (LysE YggA)
GO593_08690	COG1733	regulation of RNA biosynthetic process
GO593_08715	COG0210	DNA helicase
GO593_08720	COG0724	RNA recognition motif
GO593_08740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO593_08740	COG4651	solute:proton antiporter activity
GO593_08745	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GO593_08750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GO593_08765	COG0788	formyltetrahydrofolate deformylase activity
GO593_08910	COG2813	Specifically methylates the guanine in position
GO593_08910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GO593_08920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO593_08930	COG4774	siderophore transport
GO593_08940	COG0740	serine-type endopeptidase activity
GO593_08960	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GO593_08960	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GO593_08965	COG0280	phosphate acetyltransferase
GO593_08965	COG0857	belongs to the CobB CobQ family
GO593_08970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO593_08980	COG0800	Aldolase
GO593_08990	COG3265	gluconokinase activity
GO593_08995	COG1012	belongs to the aldehyde dehydrogenase family
GO593_09005	COG2267	carboxylic ester hydrolase activity
GO593_09020	COG0793	Belongs to the peptidase S41A family
GO593_09055	COG1426	Protein conserved in bacteria
GO593_09095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO593_09105	COG1162	GTPase activity
GO593_09110	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
GO593_09125	COG1538	Outer membrane efflux protein
GO593_09130	COG0577	efflux transmembrane transporter activity
GO593_09130	COG1136	(ABC) transporter
GO593_09135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO593_09160	COG0028	Belongs to the TPP enzyme family
GO593_09165	COG0440	acetolactate synthase activity
GO593_09195	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GO593_09210	COG0084	hydrolase, TatD family'
GO593_09225	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GO593_09235	COG0583	DNA-binding transcription factor activity
GO593_09245	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO593_09250	COG2814	Major facilitator Superfamily
GO593_09260	COG0697	spore germination
GO593_09265	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GO593_09270	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GO593_09275	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GO593_09290	COG3622	Belongs to the hyi family
GO593_09295	COG2084	Dehydrogenase
GO593_09300	COG1024	Enoyl-CoA hydratase
GO593_09305	COG2205	protein histidine kinase activity
GO593_09305	COG0784	Response regulator, receiver
GO593_09305	COG5002	protein histidine kinase activity
GO593_09325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO593_09335	COG3956	TIGRFAM MazG family protein
GO593_09340	COG1555	photosystem II stabilization
GO593_09345	COG0617	tRNA 3'-terminal CCA addition
GO593_09350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO593_09370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO593_09375	COG3028	Belongs to the UPF0307 family
GO593_09380	COG0318	PFAM AMP-dependent synthetase and ligase
GO593_09395	COG0625	glutathione transferase activity
GO593_09400	COG1238	metal cluster binding
GO593_09415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GO593_09440	COG0072	phenylalanine-tRNA ligase activity
GO593_09470	COG0248	Ppx GppA phosphatase
GO593_09480	COG0037	tRNA processing
GO593_09495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO593_09495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO593_09520	COG1764	response to oxidative stress
GO593_09525	COG1846	Transcriptional regulator
GO593_09535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO593_09595	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO593_09600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO593_09605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO593_09665	COG1214	PFAM Peptidase M22, glycoprotease
GO593_09680	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GO593_09690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GO593_09695	COG0561	phosphatase activity
GO593_09705	COG2132	Multicopper oxidase
GO593_09725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO593_09730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GO593_09735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GO593_09765	COG1063	alcohol dehydrogenase
GO593_09770	COG0583	DNA-binding transcription factor activity
GO593_09775	COG1960	acyl-CoA dehydrogenase activity
GO593_09780	COG2814	Major facilitator Superfamily
GO593_09785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GO593_09790	COG1309	transcriptional regulator
GO593_09805	COG1053	succinate dehydrogenase
GO593_09810	COG0583	DNA-binding transcription factor activity
GO593_09825	COG0583	DNA-binding transcription factor activity
GO593_09835	COG0583	DNA-binding transcription factor activity
GO593_09845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO593_09850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO593_09905	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO593_09925	COG0745	RESPONSE REGULATOR receiver
GO593_09930	COG2205	protein histidine kinase activity
GO593_09965	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GO593_09995	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO593_10000	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GO593_10020	COG0583	DNA-binding transcription factor activity
GO593_10040	COG0668	transmembrane transport
GO593_10050	COG2081	HI0933 family
GO593_10055	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GO593_10085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO593_10085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO593_10095	COG0489	protein tyrosine kinase activity
GO593_10100	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO593_10145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO593_10155	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO593_10170	COG0730	response to heat
GO593_10180	COG1196	nuclear chromosome segregation
GO593_10200	COG2223	nitrite transmembrane transporter activity
GO593_10205	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GO593_10210	COG1877	trehalose-phosphatase activity
GO593_10215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GO593_10215	COG0596	Alpha beta hydrolase
GO593_10215	COG2226	methyltransferase
GO593_10230	COG4106	trans-aconitate 2-methyltransferase activity
GO593_10245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GO593_10250	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GO593_10255	COG0009	L-threonylcarbamoyladenylate synthase
GO593_10260	COG3101	peptidyl-lysine hydroxylation
GO593_10265	COG1399	metal-binding, possibly nucleic acid-binding protein
GO593_10290	COG1652	LysM domain
GO593_10295	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GO593_10295	COG0352	thiamine-phosphate diphosphorylase activity
GO593_10295	COG0351	phosphomethylpyrimidine kinase
GO593_10305	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO593_10335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO593_10365	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
GO593_10380	COG0358	DNA primase activity
GO593_10390	COG0564	pseudouridine synthase activity
GO593_10415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
GO593_10435	COG0583	DNA-binding transcription factor activity
GO593_10440	COG0473	3-isopropylmalate dehydrogenase activity
GO593_10460	COG1012	belongs to the aldehyde dehydrogenase family
GO593_10480	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GO593_10480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO593_10540	COG0456	acetyltransferase
GO593_10550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GO593_10555	COG0492	ferredoxin-NADP+ reductase activity
GO593_10560	COG1674	ftsk spoiiie
GO593_10565	COG1280	lysine exporter protein (LysE YggA)
GO593_10580	COG2894	cell division
GO593_10595	COG0204	Acyl-transferase
GO593_10600	COG2885	chlorophyll binding
GO593_10605	COG0210	DNA helicase
GO593_10615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO593_10630	COG0121	glutamine amidotransferase
GO593_10650	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO593_10655	COG0735	belongs to the Fur family
GO593_10680	COG0420	3'-5' exonuclease activity
GO593_10700	COG1090	epimerase
GO593_10715	COG2050	protein possibly involved in aromatic compounds catabolism
GO593_10725	COG2814	Major facilitator Superfamily
GO593_10730	COG0405	Gamma-glutamyltransferase
GO593_10740	COG0582	viral genome integration into host DNA
GO593_10785	COG0629	single-stranded DNA binding
GO593_10915	COG0477	Major facilitator Superfamily
GO593_10920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO593_10965	COG0531	amino acid
GO593_10970	COG2040	homocysteine
GO593_10995	COG1309	transcriptional regulator
GO593_11000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO593_11005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO593_11015	COG1607	acyl-coa hydrolase
GO593_11025	COG0523	cobalamin synthesis protein
GO593_11035	COG4681	YaeQ
GO593_11045	COG0726	polysaccharide deacetylase
GO593_11045	COG1649	PFAM Uncharacterised BCR, COG1649
GO593_11050	COG1215	transferase activity, transferring glycosyl groups
GO593_11060	COG1024	Enoyl-CoA hydratase
GO593_11075	COG1414	Transcriptional regulator
GO593_11095	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_11110	COG2271	Major facilitator Superfamily
GO593_11120	COG2267	carboxylic ester hydrolase activity
GO593_11125	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_11140	COG0028	Belongs to the TPP enzyme family
GO593_11150	COG0477	Major facilitator Superfamily
GO593_11155	COG0242	peptide deformylase activity
GO593_11160	COG2066	Belongs to the glutaminase family
GO593_11165	COG2207	Transcriptional regulator
GO593_11170	COG2223	nitrite transmembrane transporter activity
GO593_11185	COG0583	DNA-binding transcription factor activity
GO593_11190	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_11195	COG2271	Major facilitator Superfamily
GO593_11200	COG3959	Transketolase, thiamine diphosphate binding domain
GO593_11205	COG3958	Transketolase
GO593_11215	COG0306	phosphate transporter
GO593_11235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GO593_11280	COG4181	ATPase activity
GO593_11285	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
GO593_11315	COG0583	DNA-binding transcription factor activity
GO593_11325	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO593_11330	COG1773	rubredoxin
GO593_11380	COG2851	Citrate transporter
GO593_11385	COG1253	flavin adenine dinucleotide binding
GO593_11425	COG0804	urea catabolic process
GO593_11435	COG0830	nickel cation binding
GO593_11450	COG0742	ribosomal rna small subunit methyltransferase
GO593_11455	COG0768	penicillin binding
GO593_11480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO593_11485	COG2878	Part of a membrane complex involved in electron transport
GO593_11490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO593_11500	COG3384	dioxygenase
GO593_11525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GO593_11845	COG0739	heme binding
GO593_11890	COG2194	sulfuric ester hydrolase activity
GO593_11925	COG0006	proline dipeptidase activity
GO593_11930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO593_11935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO593_11955	COG1279	arginine transmembrane transporter activity
GO593_11960	COG0583	DNA-binding transcription factor activity
GO593_12000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO593_12005	COG1388	LysM domain
GO593_12005	COG0741	lytic transglycosylase activity
GO593_12005	COG0741	lytic transglycosylase activity
GO593_12005	COG1388	LysM domain
GO593_12015	COG4174	ABC transporter (Permease)
GO593_12020	COG4239	(ABC) transporter, permease
GO593_12025	COG4172	Belongs to the ABC transporter superfamily
GO593_12045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO593_12055	COG5001	Diguanylate cyclase
GO593_12055	COG3706	GGDEF domain
GO593_12055	COG2203	Gaf domain
GO593_12055	COG4251	negative regulation of phosphorylation
GO593_12065	COG1902	pentaerythritol trinitrate reductase activity
GO593_12065	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO593_12075	COG0582	viral genome integration into host DNA
GO593_12150	COG0789	Transcriptional regulator
GO593_12210	COG2184	nucleotidyltransferase activity
GO593_12220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GO593_12245	COG1309	transcriptional regulator
GO593_12260	COG4269	membrane
GO593_12300	COG1113	amino acid transport
GO593_12310	COG0531	amino acid
GO593_12330	COG1012	belongs to the aldehyde dehydrogenase family
GO593_12350	COG1113	amino acid transport
GO593_12385	COG0697	spore germination
GO593_12390	COG2721	sulfolactate sulfo-lyase activity
GO593_12395	COG2271	Major facilitator Superfamily
GO593_12400	COG4948	Mandelate Racemase Muconate Lactonizing
GO593_12410	COG1012	belongs to the aldehyde dehydrogenase family
GO593_12415	COG2186	Transcriptional regulator
GO593_12440	COG1960	acyl-CoA dehydrogenase activity
GO593_12450	COG1012	belongs to the aldehyde dehydrogenase family
GO593_12455	COG1024	Enoyl-CoA hydratase
GO593_12460	COG2814	Major facilitator Superfamily
GO593_12475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO593_12520	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GO593_12525	COG2072	flavoprotein involved in K transport
GO593_12530	COG0300	oxidoreductase activity
GO593_12540	COG1309	transcriptional regulator
GO593_12545	COG1741	Belongs to the pirin family
GO593_12560	COG2072	flavoprotein involved in K transport
GO593_12570	COG2252	PERMEase
GO593_12575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GO593_12580	COG3038	cytochrome b561
GO593_12590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO593_12655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO593_12660	COG4197	protein conserved in bacteria, prophage-related
GO593_12740	COG5410	chromosome segregation
GO593_12745	COG3567	Phage-associated protein, HI1409 family
GO593_12765	COG3566	protein conserved in bacteria
GO593_12890	COG0582	viral genome integration into host DNA
GO593_12900	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO593_12910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GO593_12925	COG0667	Aldo Keto reductase
GO593_12935	COG1765	OsmC-like protein
GO593_12985	COG2885	chlorophyll binding
GO593_12995	COG0625	glutathione transferase activity
GO593_13015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GO593_13035	COG3634	alkyl hydroperoxide reductase activity
GO593_13045	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GO593_13055	COG0450	alkyl hydroperoxide reductase
GO593_13060	COG1643	Atp-dependent helicase
GO593_13075	COG2814	Major facilitator Superfamily
GO593_13080	COG3135	benzoate transporter
GO593_13085	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_13090	COG0633	Ferredoxin
GO593_13090	COG0543	2 iron, 2 sulfur cluster binding
GO593_13095	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GO593_13100	COG4638	Rieske (2fe-2S)
GO593_13105	COG0583	DNA-binding transcription factor activity
GO593_13155	COG1570	exodeoxyribonuclease VII activity
GO593_13190	COG1280	lysine exporter protein (LysE YggA)
GO593_13195	COG1278	Cold shock
GO593_13230	COG2814	Major facilitator Superfamily
GO593_13235	COG1733	regulation of RNA biosynthetic process
GO593_13315	COG0210	DNA helicase
GO593_13325	COG5377	YqaJ viral recombinase family
GO593_13530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO593_13530	COG0517	IMP dehydrogenase activity
GO593_13535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
GO593_13545	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
GO593_13550	COG1137	ATPase activity
GO593_13635	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
GO593_13650	COG1522	sequence-specific DNA binding
GO593_13655	COG5006	permease, DMT superfamily
GO593_13665	COG1560	Kdo2-lipid A biosynthetic process
GO593_13675	COG2814	Major facilitator Superfamily
GO593_13695	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO593_13730	COG0583	DNA-binding transcription factor activity
GO593_13735	COG1914	H( )-stimulated, divalent metal cation uptake system
GO593_13755	COG4770	biotin carboxylase activity
GO593_13760	COG0038	chloride channel
GO593_13765	COG2831	hemolysin activation secretion protein
GO593_13770	COG3210	domain, Protein
GO593_13785	COG1309	transcriptional regulator
GO593_13795	COG1063	alcohol dehydrogenase
GO593_13810	COG0439	Biotin carboxylase
GO593_13815	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO593_13820	COG1733	regulation of RNA biosynthetic process
GO593_13835	COG0864	Transcriptional regulator
GO593_13845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO593_13850	COG1116	anion transmembrane transporter activity
GO593_13915	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GO593_13915	COG2885	chlorophyll binding
GO593_13955	COG0583	DNA-binding transcription factor activity
GO593_13965	COG0590	tRNA wobble adenosine to inosine editing
GO593_13970	COG2807	transmembrane transport
GO593_13985	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GO593_14005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO593_14050	COG1012	belongs to the aldehyde dehydrogenase family
GO593_14055	COG0531	amino acid
GO593_14060	COG1760	l-serine dehydratase
GO593_14065	COG2030	dehydratase
GO593_14065	COG1012	belongs to the aldehyde dehydrogenase family
GO593_14070	COG3396	Phenylacetate-CoA oxygenase
GO593_14075	COG3460	Phenylacetate-CoA oxygenase
GO593_14080	COG3396	Phenylacetate-CoA oxygenase
GO593_14085	COG2151	metal-sulfur cluster biosynthetic enzyme
GO593_14090	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO593_14095	COG1024	Enoyl-CoA hydratase
GO593_14100	COG1024	Enoyl-CoA hydratase
GO593_14105	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO593_14110	COG0183	Belongs to the thiolase family
GO593_14115	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GO593_14120	COG3327	negative regulation of DNA-templated transcription, initiation
GO593_14130	COG2050	protein possibly involved in aromatic compounds catabolism
GO593_14170	COG2207	Transcriptional regulator
GO593_14185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GO593_14190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO593_14195	COG2271	Major facilitator Superfamily
GO593_14200	COG0753	catalase activity
GO593_14205	COG3038	cytochrome b561
GO593_14225	COG2267	carboxylic ester hydrolase activity
GO593_14230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO593_14235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO593_14240	COG1012	belongs to the aldehyde dehydrogenase family
GO593_14250	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GO593_14260	COG1012	belongs to the aldehyde dehydrogenase family
GO593_14265	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO593_14270	COG0583	DNA-binding transcription factor activity
GO593_14280	COG1414	Transcriptional regulator
GO593_14285	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO593_14295	COG1840	ABC-type Fe3 transport system, periplasmic component
GO593_14300	COG3842	ATPase activity
GO593_14315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO593_14320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO593_14325	COG2814	Major facilitator Superfamily
GO593_14330	COG1960	acyl-CoA dehydrogenase activity
GO593_14345	COG1024	Enoyl-CoA hydratase
GO593_14355	COG2814	Major facilitator Superfamily
GO593_14365	COG0183	Belongs to the thiolase family
GO593_14370	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO593_14375	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_14380	COG1024	Enoyl-CoA hydratase
GO593_14385	COG1960	acyl-CoA dehydrogenase activity
GO593_14390	COG2814	Major facilitator Superfamily
GO593_14395	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GO593_14400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO593_14410	COG2814	Major facilitator Superfamily
GO593_14420	COG1960	acyl-CoA dehydrogenase activity
GO593_14435	COG0583	DNA-binding transcription factor activity
GO593_14450	COG1024	Enoyl-CoA hydratase
GO593_14455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO593_14460	COG1960	acyl-CoA dehydrogenase activity
GO593_14465	COG1309	transcriptional regulator
GO593_14470	COG0318	PFAM AMP-dependent synthetase and ligase
GO593_14490	COG0583	DNA-binding transcription factor activity
GO593_14535	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_14555	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO593_14575	COG0784	Response regulator, receiver
GO593_14575	COG2205	protein histidine kinase activity
GO593_14595	COG0765	amino acid transport
GO593_14600	COG0765	amino acid transport
GO593_14605	COG1126	abc transporter atp-binding protein
GO593_14610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO593_14615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO593_14630	COG1280	lysine exporter protein (LysE YggA)
GO593_14635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO593_14640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO593_14645	COG1045	serine acetyltransferase
GO593_14660	COG0583	DNA-binding transcription factor activity
GO593_14665	COG0625	glutathione transferase activity
GO593_14670	COG0625	glutathione transferase activity
GO593_14675	COG0583	DNA-binding transcription factor activity
GO593_14685	COG1346	cytolysis
GO593_14705	COG2814	Major facilitator Superfamily
GO593_14715	COG0583	DNA-binding transcription factor activity
GO593_14725	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
GO593_14730	COG3052	prosthetic group binding
GO593_14770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO593_14780	COG1294	oxidase, subunit
GO593_14785	COG1271	oxidase subunit
GO593_14805	COG0477	Major facilitator Superfamily
GO593_14815	COG4521	taurine ABC transporter
GO593_14820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
GO593_14825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO593_14830	COG2175	clavaminate synthase activity
GO593_14840	COG1953	Uracil, thiamine, allantoin
GO593_14850	COG0583	DNA-binding transcription factor activity
GO593_14860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GO593_14875	COG0640	Transcriptional regulator
GO593_14880	COG0798	PFAM Bile acid sodium symporter
GO593_14885	COG0583	DNA-binding transcription factor activity
GO593_14900	COG3634	alkyl hydroperoxide reductase activity
GO593_14940	COG0436	Aminotransferase
GO593_14950	COG0386	Belongs to the glutathione peroxidase family
GO593_14990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GO593_15015	COG0012	GTP binding
GO593_15020	COG2011	ABC-type metal ion transport system permease component
GO593_15025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO593_15035	COG1464	Belongs to the NlpA lipoprotein family
GO593_15065	COG0765	amino acid transport
GO593_15070	COG0765	amino acid transport
GO593_15075	COG1126	abc transporter atp-binding protein
GO593_15085	COG1522	sequence-specific DNA binding
GO593_15100	COG1309	transcriptional regulator
GO593_15110	COG1484	DNA-dependent DNA replication
GO593_15115	COG4584	PFAM Integrase catalytic
GO593_15130	COG1002	Type II restriction enzyme, methylase subunits
GO593_15135	COG1061	Type III restriction enzyme res subunit
GO593_15145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO593_15175	COG0583	DNA-binding transcription factor activity
GO593_15185	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GO593_15195	COG0697	spore germination
GO593_15220	COG3121	Chaperone
GO593_15225	COG3539	Fimbrial protein
GO593_15250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GO593_15250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GO593_15295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO593_15305	COG2353	YceI-like domain
GO593_15315	COG3698	Phosphodiester glycosidase
GO593_15330	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GO593_15335	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GO593_15335	COG0506	proline dehydrogenase activity
GO593_15335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GO593_15345	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO593_15350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GO593_15370	COG1132	(ABC) transporter
GO593_15375	COG3122	Protein conserved in bacteria
GO593_15380	COG3619	membrane
GO593_15390	COG0640	Transcriptional regulator
GO593_15400	COG2850	peptidyl-arginine hydroxylation
GO593_15405	COG0424	maF-like protein
GO593_15425	COG0191	fructose-bisphosphate aldolase activity
GO593_15430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO593_15445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GO593_15455	COG1192	Involved in chromosome partitioning
GO593_15460	COG1475	DNA binding
GO593_15465	COG0811	peptide transport
GO593_15475	COG1132	(ABC) transporter
GO593_15480	COG1663	tetraacyldisaccharide 4'-kinase activity
GO593_15500	COG0084	hydrolase, TatD family'
GO593_15515	COG2165	general secretion pathway protein
GO593_15545	COG0590	tRNA wobble adenosine to inosine editing
GO593_15565	COG0776	regulation of translation
GO593_15595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GO593_15600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GO593_15650	COG0339	signal peptide processing
GO593_15660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO593_15695	COG0702	epimerase
GO593_15700	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO593_15720	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GO593_15750	COG0316	Belongs to the HesB IscA family
GO593_15755	COG0822	iron-sulfur transferase activity
GO593_15780	COG0776	regulation of translation
GO593_15785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO593_15790	COG2207	Transcriptional regulator
GO593_15795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO593_15800	COG1960	acyl-CoA dehydrogenase activity
GO593_15805	COG1960	acyl-CoA dehydrogenase activity
GO593_15820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GO593_15840	COG4264	IucA IucC family
GO593_15845	COG4264	IucA IucC family
GO593_15855	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
GO593_15905	COG0406	alpha-ribazole phosphatase activity
GO593_15920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO593_15925	COG0730	response to heat
GO593_15945	COG4773	Receptor
GO593_15950	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO593_15965	COG1131	(ABC) transporter
GO593_15970	COG0842	Transport permease protein
GO593_15975	COG0842	Transport permease protein
GO593_16030	COG2226	methyltransferase
GO593_16055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO593_16075	COG3706	GGDEF domain
GO593_16090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO593_16095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO593_16100	COG0022	dehydrogenase e1 component
GO593_16105	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO593_16110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO593_16120	COG1063	alcohol dehydrogenase
GO593_16125	COG3781	membrane
GO593_16135	COG3453	Protein conserved in bacteria
GO593_16135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO593_16145	COG0730	response to heat
GO593_16160	COG2207	Transcriptional regulator
GO593_16160	COG3708	Transcriptional regulator
GO593_16165	COG1733	regulation of RNA biosynthetic process
GO593_16170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO593_16195	COG4521	taurine ABC transporter
GO593_16200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO593_16220	COG0477	Major facilitator Superfamily
GO593_16230	COG1027	Aspartate ammonia-lyase
GO593_16245	COG0583	DNA-binding transcription factor activity
GO593_16250	COG0583	DNA-binding transcription factor activity
GO593_16255	COG0183	Belongs to the thiolase family
GO593_16260	COG2031	fatty acid transporter
GO593_16275	COG0583	DNA-binding transcription factor activity
GO593_16295	COG1309	transcriptional regulator
GO593_16305	COG2610	gluconate transmembrane transporter activity
GO593_16310	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_16315	COG2207	Transcriptional regulator
GO593_16325	COG0412	Dienelactone hydrolase
GO593_16330	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_16340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO593_16355	COG0543	2 iron, 2 sulfur cluster binding
GO593_16355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO593_16360	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
GO593_16365	COG4638	Rieske (2fe-2S)
GO593_16375	COG0725	ABC transporter, periplasmic molybdate-binding protein
GO593_16380	COG4149	molybdate abc transporter
GO593_16385	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GO593_16390	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_16395	COG1535	isochorismatase
GO593_16395	COG3433	isochorismatase activity
GO593_16460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO593_16475	COG0753	catalase activity
GO593_16485	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GO593_16525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO593_16530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO593_16535	COG0745	RESPONSE REGULATOR receiver
GO593_16540	COG2205	protein histidine kinase activity
GO593_16550	COG2207	Transcriptional regulator
GO593_16565	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_16580	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
GO593_16625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
GO593_16695	COG1401	restriction endodeoxyribonuclease activity
GO593_16740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO593_16760	COG1120	ATPase activity
GO593_16775	COG1064	alcohol dehydrogenase
GO593_16790	COG2207	Transcriptional regulator
GO593_16795	COG2084	Dehydrogenase
GO593_16805	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO593_16810	COG0583	DNA-binding transcription factor activity
GO593_16820	COG0129	dihydroxy-acid dehydratase activity
GO593_16825	COG1012	belongs to the aldehyde dehydrogenase family
GO593_16840	COG1566	PFAM secretion protein HlyD family protein
GO593_16855	COG0583	DNA-binding transcription factor activity
GO593_16905	COG3210	domain, Protein
GO593_16910	COG2831	hemolysin activation secretion protein
GO593_16925	COG0318	PFAM AMP-dependent synthetase and ligase
GO593_16935	COG1960	acyl-CoA dehydrogenase activity
GO593_16945	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_16950	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_16955	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_16960	COG0583	DNA-binding transcription factor activity
GO593_16965	COG1309	transcriptional regulator
GO593_16990	COG0789	Transcriptional regulator
GO593_17005	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO593_17005	COG1902	pentaerythritol trinitrate reductase activity
GO593_17020	COG1012	belongs to the aldehyde dehydrogenase family
GO593_17040	COG2186	Transcriptional regulator
GO593_17050	COG0583	DNA-binding transcription factor activity
GO593_17055	COG4948	Mandelate Racemase Muconate Lactonizing
GO593_17060	COG4829	muconolactone delta-isomerase
GO593_17070	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GO593_17075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO593_17080	COG0183	Belongs to the thiolase family
GO593_17085	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GO593_17095	COG1012	belongs to the aldehyde dehydrogenase family
GO593_17105	COG3733	amine oxidase
GO593_17115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO593_17125	COG1028	Short-chain dehydrogenase reductase Sdr
GO593_17135	COG4638	Rieske (2fe-2S)
GO593_17155	COG0154	amidase activity
GO593_17165	COG2814	Major facilitator Superfamily
GO593_17190	COG1960	acyl-CoA dehydrogenase activity
GO593_17195	COG0583	DNA-binding transcription factor activity
GO593_17200	COG1414	Transcriptional regulator
GO593_17215	COG2391	methyltransferase activity
GO593_17225	COG4993	Dehydrogenase
GO593_17230	COG3659	wide pore channel activity
GO593_17235	COG3420	alginic acid biosynthetic process
GO593_17240	COG0710	3-dehydroquinate dehydratase activity
GO593_17245	COG3485	protocatechuate 3,4-dioxygenase
GO593_17250	COG3485	protocatechuate 3,4-dioxygenase
GO593_17255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO593_17260	COG2271	Major facilitator Superfamily
GO593_17265	COG0596	Alpha beta hydrolase
GO593_17270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO593_17275	COG0183	Belongs to the thiolase family
GO593_17280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO593_17285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GO593_17295	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GO593_17300	COG2323	membrane
GO593_17345	COG1902	pentaerythritol trinitrate reductase activity
GO593_17345	COG0446	pyridine nucleotide-disulphide oxidoreductase
GO593_17360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GO593_17370	COG0542	response to heat
GO593_17375	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GO593_17405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GO593_17410	COG0569	domain protein
GO593_17415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO593_17430	COG4774	siderophore transport
GO593_17435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO593_17445	COG1585	Membrane protein implicated in regulation of membrane protease activity
GO593_17460	COG1294	oxidase, subunit
GO593_17465	COG4890	Cyd operon protein YbgT
GO593_17475	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
GO593_17485	COG0552	protein localization to endoplasmic reticulum
GO593_17510	COG0517	IMP dehydrogenase activity
GO593_17510	COG0516	GMP reductase activity
GO593_17515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO593_17520	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GO593_17530	COG0583	DNA-binding transcription factor activity
GO593_17535	COG0024	Methionine aminopeptidase
GO593_17565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO593_17565	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO593_17570	COG1105	Belongs to the carbohydrate kinase PfkB family
GO593_17575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO593_17575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO593_17575	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
GO593_17595	COG3300	MHYT domain
GO593_17595	COG5001	Diguanylate cyclase
GO593_17610	COG2135	peptidase activity
GO593_17615	COG0659	secondary active sulfate transmembrane transporter activity
GO593_17630	COG1113	amino acid transport
GO593_17640	COG1522	sequence-specific DNA binding
GO593_17665	COG1011	Hydrolase
GO593_17670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GO593_17680	COG2137	regulation of response to DNA damage stimulus
GO593_17695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO593_17730	COG0575	Belongs to the CDS family
GO593_17735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO593_17760	COG3852	Histidine kinase
GO593_17765	COG2204	response regulator
GO593_17820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO593_17825	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
GO593_17845	COG0697	spore germination
GO593_17850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO593_17860	COG0303	'Molybdopterin
GO593_17865	COG0315	cyclic pyranopterin monophosphate synthase activity
GO593_17865	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO593_17880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GO593_17895	COG0243	molybdopterin cofactor binding
GO593_17900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO593_17905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO593_17905	COG2146	nitrite reductase [NAD(P)H] activity
GO593_17915	COG0745	RESPONSE REGULATOR receiver
GO593_17920	COG1116	anion transmembrane transporter activity
GO593_17920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO593_17940	COG0511	ligase activity, forming carbon-carbon bonds
GO593_17955	COG2814	Major facilitator Superfamily
GO593_17975	COG0069	glutamate synthase activity
GO593_17995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO593_18005	COG1454	alcohol dehydrogenase
GO593_18010	COG0824	Thioesterase
GO593_18020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GO593_18050	COG0183	Belongs to the thiolase family
GO593_18060	COG0583	DNA-binding transcription factor activity
GO593_18075	COG1522	sequence-specific DNA binding
GO593_18080	COG3135	benzoate transporter
GO593_18090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GO593_18105	COG0589	response to stress
GO593_18110	COG0488	(ABC) transporter
GO593_18130	COG4773	Receptor
GO593_18160	COG0668	transmembrane transport
GO593_18170	COG1309	transcriptional regulator
GO593_18185	COG1605	Chorismate mutase
GO593_18225	COG0308	aminopeptidase N
GO593_18250	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO593_18255	COG1454	alcohol dehydrogenase
GO593_18275	COG0531	amino acid
GO593_18280	COG4303	Ethanolamine ammonia lyase large subunit
GO593_18285	COG4302	ethanolamine ammonia-lyase activity
GO593_18290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO593_18290	COG0519	Catalyzes the synthesis of GMP from XMP
GO593_18305	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GO593_18320	COG0697	spore germination
GO593_18325	COG1923	regulation of RNA biosynthetic process
GO593_18335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GO593_18340	COG0802	atpase or kinase
GO593_18360	COG1187	pseudouridine synthase activity
GO593_18375	COG0583	DNA-binding transcription factor activity
GO593_18390	COG2814	Major facilitator Superfamily
GO593_18395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO593_18420	COG0729	surface antigen
GO593_18440	COG0174	glutamine synthetase
GO593_18445	COG0745	RESPONSE REGULATOR receiver
GO593_18450	COG2205	protein histidine kinase activity
GO593_18460	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GO593_18465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GO593_18490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO593_18495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO593_18530	COG0583	DNA-binding transcription factor activity
GO593_18545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO593_18555	COG3658	cytochrome
GO593_18560	COG1215	transferase activity, transferring glycosyl groups
GO593_18565	COG1649	PFAM Uncharacterised BCR, COG1649
GO593_18565	COG0726	polysaccharide deacetylase
GO593_18590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO593_18595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO593_18605	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO593_18630	COG0305	Participates in initiation and elongation during chromosome replication
GO593_18635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO593_18645	COG1305	Transglutaminase-like
GO593_18655	COG2308	Evidence 4 Homologs of previously reported genes of
GO593_18685	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
GO593_18690	COG0138	bifunctional purine biosynthesis protein purh
GO593_18695	COG0151	Belongs to the GarS family
GO593_18700	COG1464	Belongs to the NlpA lipoprotein family
GO593_18705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO593_18710	COG2011	ABC-type metal ion transport system permease component
GO593_18715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO593_18725	COG1301	dicarboxylic acid transport
GO593_18755	COG1794	racemase activity, acting on amino acids and derivatives
GO593_18775	COG0745	RESPONSE REGULATOR receiver
GO593_18780	COG0642	Histidine kinase
GO593_18785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GO593_18795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GO593_18835	COG2351	hydroxyisourate hydrolase activity
GO593_18845	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GO593_18845	COG3008	intermembrane lipid transfer
GO593_18850	COG2995	paraquat-inducible protein a
GO593_18880	COG1051	belongs to the nudix hydrolase family
GO593_18885	COG0477	Major facilitator Superfamily
GO593_18940	COG2186	Transcriptional regulator
GO593_18980	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
GO593_19005	COG1764	response to oxidative stress
GO593_19010	COG1846	Transcriptional regulator