locus-tag class description HYI42_00060 ENOG4105X0I Fimbrial HYI42_00110 ENOG4107RZC phospholipase d HYI42_00115 ENOG4107RZC phospholipase d HYI42_00170 ENOG4107T31 5'-nucleotidase HYI42_00180 ENOG4105WQI isochorismatase HYI42_00185 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HYI42_00195 ENOG4105E0C molybdate abc transporter HYI42_00200 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HYI42_00205 ENOG4105F4R Transcriptional regulator mode HYI42_00210 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HYI42_00215 ENOG4108YS2 small subunit HYI42_00220 ENOG4105F57 Anthranilate dioxygenase reductase HYI42_00250 ENOG4105CHR reductase HYI42_00260 ENOG4105D2S major facilitator superfamily HYI42_00270 ENOG4105DTD Dehydrogenase HYI42_00275 ENOG4105CY2 Citrate transporter HYI42_00300 ENOG4105CRW Short chain fatty acid transporter HYI42_00305 ENOG4105CHU acetyl-coa acetyltransferase HYI42_00330 ENOG4108IJ0 Aspartate ammonia-lyase HYI42_00340 ENOG4105CSH Transporter HYI42_00360 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HYI42_00365 ENOG4106FTQ Taurine ABC transporter, periplasmic HYI42_00390 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HYI42_00395 ENOG4105KVH Transcriptional regulator HYI42_00400 ENOG4105UEI Transcriptional Regulator AraC Family HYI42_00415 ENOG4108VCT Sulfite exporter TauE/SafE HYI42_00425 ENOG4107S76 domain protein HYI42_00435 ENOG4105FFC UPF0187 protein HYI42_00445 ENOG4105CHR reductase HYI42_00460 ENOG4105CPP Dehydrogenase, E1 component HYI42_00465 ENOG4107R0V Pyruvate dehydrogenase HYI42_00470 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HYI42_00485 ENOG4105BZU Histidine kinase HYI42_00495 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HYI42_00500 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HYI42_00545 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HYI42_00560 ENOG4105C28 cystathionine HYI42_00570 ENOG4105F2W methyltransferase HYI42_00600 ENOG4105K59 histidine triad (HIT) protein HYI42_00625 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HYI42_00630 ENOG4105CNM Receptor HYI42_00650 ENOG4107TSN permease HYI42_00655 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HYI42_00670 ENOG4107TB6 phosphoglycerate mutase HYI42_00675 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HYI42_00680 ENOG4108YZT Adenosylcobinamide kinase HYI42_00690 ENOG4107VXZ Hydrolase HYI42_00720 ENOG4105JSC dimethylmenaquinone methyltransferase HYI42_00730 ENOG4105DJU Siderophore biosynthesis protein HYI42_00735 ENOG4105DUU IucA IucC family protein HYI42_00740 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYI42_00755 ENOG4108Z66 YbaK ebsC protein HYI42_00770 ENOG4105C1G acyl-Coa dehydrogenase HYI42_00775 ENOG4105C1G acyl-Coa dehydrogenase HYI42_00780 ENOG4105EEF Alkane 1-monooxygenase HYI42_00785 ENOG4105E7U AraC family transcriptional regulator HYI42_00790 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HYI42_00795 ENOG4105K70 DNA-binding protein HYI42_00810 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HYI42_00820 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HYI42_00825 ENOG4108Z4V iron-sulfur cluster assembly HYI42_00840 ENOG4108ZIT Ferredoxin, 2FE-2S HYI42_00845 ENOG4105F8J Adenylate Guanylate cyclase HYI42_00865 ENOG4108JA2 transcriptioN-repair coupling factor HYI42_00885 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HYI42_00905 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HYI42_00925 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HYI42_00935 ENOG4105DGW oligopeptidase A HYI42_00955 ENOG4108DNJ Pfam:TonB HYI42_00970 ENOG4105SG9 biopolymer transport protein, ExbD HYI42_00980 ENOG4107QP3 malate synthase g HYI42_00985 ENOG4105D6Z AFG1 family ATPase HYI42_00995 ENOG4107RN6 Monooxygenase HYI42_01015 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HYI42_01020 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HYI42_01035 ENOG4108Z6B deaminase HYI42_01055 ENOG4108RTD type II secretion system protein K HYI42_01080 ENOG4105F8V Hydrolase, tatD family HYI42_01090 ENOG4107QRG dna polymerase iii HYI42_01100 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HYI42_01105 ENOG4105BZ1 (ABC) transporter HYI42_01120 ENOG4105FA0 parb-like partition protein HYI42_01125 ENOG4107QJE Chromosome Partitioning Protein HYI42_01135 ENOG4108S0S Nucleotidyl transferase HYI42_01140 ENOG4105EHM Aminoglycoside phosphotransferase HYI42_01145 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HYI42_01150 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HYI42_01155 ENOG4105D2N Aldolase HYI42_01175 ENOG4108UHJ MAF-like protein HYI42_01180 ENOG4105EZE Cupin 4 family protein HYI42_01190 ENOG41080HT Transcriptional regulator, arsr family HYI42_01200 ENOG4105XPP Protein of unknown function (DUF1275) HYI42_01205 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HYI42_01220 ENOG4108ZX5 transcriptional regulator HYI42_01230 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HYI42_01235 ENOG4105CK7 Sodium proline symporter HYI42_01240 ENOG4105EW9 transcriptional regulator AsnC family HYI42_01245 ENOG4105C26 Dehydrogenase HYI42_01275 ENOG4108YYC ycei family HYI42_01285 ENOG4105CV1 Transketolase (EC 2.2.1.1) HYI42_01310 ENOG4108HWY Beta-lactamase HYI42_01330 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HYI42_01335 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HYI42_01355 ENOG4105X0I Fimbrial HYI42_01385 ENOG4108IPJ Membrane HYI42_01395 ENOG4105ETS cytosine purines uracil thiamine allantoin HYI42_01405 ENOG4105CC0 LysR family Transcriptional regulator HYI42_01440 ENOG4105EW9 transcriptional regulator AsnC family HYI42_01450 ENOG4105CDA abc transporter atp-binding protein HYI42_01455 ENOG4105DRP amino acid AbC transporter HYI42_01460 ENOG4105EAD ABC transporter HYI42_01475 ENOG4107T8P acyl-Coa dehydrogenase HYI42_01490 ENOG4105D01 (LipO)protein HYI42_01500 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HYI42_01505 ENOG4108UMI ABC transporter, permease HYI42_01510 ENOG4105C3G gtp-binding protein HYI42_01535 ENOG4108UMN azlc family HYI42_01540 ENOG4105ZED uncharacterized protein ygaH HYI42_01570 ENOG4105E7U AraC family transcriptional regulator HYI42_01575 ENOG4108V06 Glutathione peroxidase HYI42_01585 ENOG4105CHM Aminotransferase HYI42_01590 ENOG4105CK2 sodium dicarboxylate symporter HYI42_01600 ENOG4105C0B DNA polymerase III (alpha subunit) HYI42_01625 ENOG4108JU3 Alkyl hydroperoxide reductase HYI42_01640 ENOG4108KB2 LysR family Transcriptional regulator HYI42_01645 ENOG4105D6J arsenicaL-resistance protein HYI42_01650 ENOG41082YX Transcriptional regulator, arsr family HYI42_01665 ENOG4105CPN adenine deaminase HYI42_01685 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HYI42_01700 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HYI42_01705 ENOG4108IY8 ABC, transporter HYI42_01710 ENOG4106FTQ Taurine ABC transporter, periplasmic HYI42_01720 ENOG4105C54 Major Facilitator superfamily HYI42_01740 ENOG4105C4M (Ubiquinol oxidase) subunit I HYI42_01745 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HYI42_01755 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYI42_01775 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HYI42_01795 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) HYI42_01800 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase HYI42_01810 ENOG4105DXI Major Facilitator superfamily HYI42_01825 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYI42_01830 ENOG41067MG lrgb family HYI42_01835 ENOG4105VAW lrga family HYI42_01840 ENOG4105CMU LysR family (Transcriptional regulator HYI42_01845 ENOG4108SHQ Glutathione S-transferase HYI42_01850 ENOG4105CYM Glutathione S-transferase HYI42_01855 ENOG4105CBN LysR family transcriptional regulator HYI42_01860 ENOG4105CHR reductase HYI42_01870 ENOG4105D7W serine acetyltransferase HYI42_01875 ENOG4105ESN nucleotide-binding protein HYI42_01880 ENOG4105C9B Cysteine desulfurase HYI42_01885 ENOG4105CCF Lysine exporter protein (Lyse ygga) HYI42_01890 ENOG4105EXG Transcriptional regulator HYI42_01900 ENOG4105CT1 (ABC) transporter HYI42_01905 ENOG4107RP9 extracellular solute-binding protein, family 3 HYI42_01910 ENOG4105CDA abc transporter atp-binding protein HYI42_01915 ENOG4108HW4 amino acid AbC transporter HYI42_01920 ENOG4105EAD ABC transporter HYI42_01935 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HYI42_01940 ENOG4105BZU Histidine kinase HYI42_01950 ENOG4105EW9 transcriptional regulator AsnC family HYI42_02030 ENOG4105HEI LysR family (Transcriptional regulator HYI42_02050 ENOG4105CEY Amp-dependent synthetase and ligase HYI42_02055 ENOG4105R8C Transcriptional regulator HYI42_02060 ENOG4105C1G acyl-Coa dehydrogenase HYI42_02065 ENOG4107QX3 carboxylase HYI42_02070 ENOG4105E39 Enoyl-CoA hydratase HYI42_02085 ENOG4105CC0 LysR family Transcriptional regulator HYI42_02100 ENOG4105CSU acyl-Coa dehydrogenase HYI42_02120 ENOG4107QNJ CoA-transferase subunit B HYI42_02125 ENOG4107QP7 CoA-transferase subunit A HYI42_02130 ENOG4107RGD Major Facilitator superfamily HYI42_02135 ENOG4105C1G acyl-Coa dehydrogenase HYI42_02140 ENOG4105E39 Enoyl-CoA hydratase HYI42_02145 ENOG4105CHR reductase HYI42_02150 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HYI42_02155 ENOG4105CHU acetyl-coa acetyltransferase HYI42_02165 ENOG4105EQ0 Major Facilitator superfamily HYI42_02170 ENOG4105EA8 2-Nitropropane dioxygenase HYI42_02175 ENOG4108UKI Enoyl-CoA hydratase HYI42_02185 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HYI42_02190 ENOG4105C1G acyl-Coa dehydrogenase HYI42_02195 ENOG4107RGD Major Facilitator superfamily HYI42_02200 ENOG4108KAZ Involved in phosphonate degradation (By similarity) HYI42_02205 ENOG4107STF Involved in phosphonate degradation (By similarity) HYI42_02215 ENOG4107RCV ABC transporter, permease HYI42_02220 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HYI42_02225 ENOG4105C4Y ABC transporter HYI42_02235 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HYI42_02240 ENOG4107HP6 Transcriptional regulator HYI42_02250 ENOG4105HEI LysR family (Transcriptional regulator HYI42_02255 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HYI42_02260 ENOG4105C26 Dehydrogenase HYI42_02270 ENOG4105ETS cytosine purines uracil thiamine allantoin HYI42_02280 ENOG4105C26 Dehydrogenase HYI42_02285 ENOG4108M8W Monooxygenase HYI42_02290 ENOG4105MXW flavin reductase domain protein, FMN-binding HYI42_02295 ENOG4108MXF Alpha Beta Hydrolase HYI42_02315 ENOG4105CPW cytochrome b561 HYI42_02320 ENOG4107VGR Catalase HYI42_02330 ENOG4105CSP Major Facilitator Superfamily HYI42_02335 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HYI42_02340 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HYI42_02410 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HYI42_02415 ENOG4107YAU phenylacetic acid degradation protein HYI42_02420 ENOG4108Z0R Transferase HYI42_02425 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HYI42_02430 ENOG4105DZS Phenylacetate-CoA ligase HYI42_02435 ENOG4105CHU acetyl-coa acetyltransferase HYI42_02440 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HYI42_02445 ENOG4108UKI Enoyl-CoA hydratase HYI42_02450 ENOG4105E39 Enoyl-CoA hydratase HYI42_02455 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HYI42_02460 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HYI42_02465 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HYI42_02470 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HYI42_02475 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HYI42_02480 ENOG4105DXM phenylacetic acid degradation protein HYI42_02485 ENOG4105EJQ L-serine dehydratase HYI42_02490 ENOG4107QTZ amino acid HYI42_02495 ENOG4105CZJ Aldehyde dehydrogenase HYI42_02520 ENOG4105MWK D-amino acid dehydrogenase, small subunit HYI42_02540 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYI42_02550 ENOG4108Z4X TRANSCRIPTIONal HYI42_02560 ENOG4105WPN DNA integration recombination invertion protein HYI42_02575 ENOG4105DJ2 Major Facilitator Superfamily HYI42_02580 ENOG4107Y2X deaminase HYI42_02590 ENOG4105EMY transcriptional regulator HYI42_02700 ENOG4108HW3 (ABC) transporter HYI42_02710 ENOG4105MRR Transcriptional regulator (By similarity) HYI42_02725 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF HYI42_02730 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HYI42_02745 ENOG4105E2A Dehydrogenase HYI42_02755 ENOG4105R8C Transcriptional regulator HYI42_02780 ENOG4107R4J Chloride channel HYI42_02785 ENOG4108JIK carboxylase HYI42_02805 ENOG4105C5A transporter HYI42_02810 ENOG4108WAV Transcriptional regulator HYI42_02840 ENOG4105CNA YD repeat protein HYI42_02870 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) HYI42_02900 ENOG4105D1S lipid A biosynthesis HYI42_02910 ENOG4107AQZ Membrane HYI42_02930 ENOG4108Z4U Ferredoxin HYI42_02970 ENOG4105DFG type I secretion outer membrane protein HYI42_02975 ENOG4108IUZ ABC transporter HYI42_02980 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HYI42_02995 ENOG4105C2X Arabinose 5-phosphate isomerase HYI42_03065 ENOG41090AG Bacteriophage protein HYI42_03085 ENOG4107ZQ5 Phage-associated protein, HI1409 family HYI42_03185 ENOG4105II7 pyrroline-5-carboxylate reductase HYI42_03195 ENOG4105VEQ Cold shock protein HYI42_03230 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HYI42_03280 ENOG4108KB2 LysR family Transcriptional regulator HYI42_03285 ENOG4105FUY alpha subunit HYI42_03290 ENOG4108UKV benzoate 1,2-dioxygenase HYI42_03295 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein HYI42_03300 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase HYI42_03305 ENOG4105DKK Benzoate HYI42_03310 ENOG4105D2S major facilitator superfamily HYI42_03325 ENOG4105CQ7 ATP-dependent helicase HYI42_03330 ENOG4105D3R alkyl hydroperoxide reductase HYI42_03340 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HYI42_03350 ENOG4108JU3 Alkyl hydroperoxide reductase HYI42_03360 ENOG4108K3A Glutathione S-transferase HYI42_03370 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HYI42_03375 ENOG4108TGY Glutathione S-transferase HYI42_03385 ENOG4108ZG0 Ompa motb domain protein HYI42_03390 ENOG4105CD3 dihydroorotase HYI42_03420 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HYI42_03435 ENOG4108UKZ OsmC family HYI42_03440 ENOG4107RYR Transcriptional regulator, Crp Fnr family HYI42_03445 ENOG4105CPC Aldo Keto reductase HYI42_03460 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HYI42_03470 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HYI42_03575 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HYI42_03865 ENOG41083X2 DNA polymerase III, epsilon subunit HYI42_03905 ENOG4105CFH Aspartokinase HYI42_03915 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HYI42_03925 ENOG4105CPW cytochrome b561 HYI42_03930 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HYI42_03935 ENOG4105C7N Xanthine uracil vitamin C permease HYI42_03945 ENOG4105F95 Monooxygenase HYI42_03980 ENOG4105F95 Monooxygenase HYI42_03985 ENOG4105JQZ Methyltransferase HYI42_03995 ENOG4107RN6 Monooxygenase HYI42_04015 ENOG4105EPF Outer membrane porin HYI42_04020 ENOG4105D2S major facilitator superfamily HYI42_04030 ENOG4105E3J oxidoreductase HYI42_04045 ENOG4108SC4 )-transporter HYI42_04050 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HYI42_04065 ENOG4105C1G acyl-Coa dehydrogenase HYI42_04070 ENOG4105EPF Outer membrane porin HYI42_04075 ENOG4105NI3 Protein of unknown function (DUF3237) HYI42_04090 ENOG4105JXH GntR family transcriptional regulator HYI42_04095 ENOG4105CZJ Aldehyde dehydrogenase HYI42_04105 ENOG4105EQX glucarate dehydratase HYI42_04110 ENOG4105DJB Major Facilitator Superfamily HYI42_04115 ENOG4105CTX dehydratase HYI42_04120 ENOG4105DJP Membrane HYI42_04125 ENOG4108ZX5 transcriptional regulator HYI42_04150 ENOG4105C85 amino acid HYI42_04170 ENOG4105C26 Dehydrogenase HYI42_04190 ENOG4105CUB amino acid HYI42_04200 ENOG4105C85 amino acid HYI42_04235 ENOG4105CNA YD repeat protein HYI42_04255 ENOG4105D01 (LipO)protein HYI42_04265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYI42_04285 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HYI42_04345 ENOG4108JQ5 ABC transporter HYI42_04350 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HYI42_04355 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HYI42_04365 ENOG4105E9H Lytic Murein transglycosylase HYI42_04365 ENOG4105E9H Lytic Murein transglycosylase HYI42_04370 ENOG4107RZZ dna polymerase iii epsilon subunit HYI42_04380 ENOG4105E09 nadh pyrophosphatase HYI42_04390 ENOG4105W4M Transport-associated protein HYI42_04400 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HYI42_04410 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) HYI42_04415 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HYI42_04435 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HYI42_04440 ENOG4105D0A hydroxylase HYI42_04445 ENOG4107RAQ aminopeptidase HYI42_04505 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HYI42_04515 ENOG4105D82 Glutamate dehydrogenase HYI42_04520 ENOG4108R3D Electron transport complex HYI42_04525 ENOG4105CSM endonuclease III HYI42_04550 ENOG4105CJN penicillin-binding protein HYI42_04555 ENOG4106H78 methyltransferase HYI42_04570 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) HYI42_04580 ENOG4105CQM Urea amidohydrolase subunit alpha HYI42_04610 ENOG4107RET Isocitrate lyase HYI42_04620 ENOG4105C37 (CBS) domain HYI42_04625 ENOG4105D4T Citrate transporter HYI42_04640 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HYI42_04655 ENOG4108MRJ HYI42_04675 ENOG4105VCQ rubredoxin HYI42_04680 ENOG4107QZF nitrite reductase NADPH large subunit HYI42_04690 ENOG4105C5Q Transcriptional regulator HYI42_04715 ENOG4107U91 Rhomboid family HYI42_04720 ENOG4105CV6 ABC transporter, permease HYI42_04725 ENOG4108I0Y (ABC) transporter HYI42_04730 ENOG4108UJV acyl-CoA thioesterase i HYI42_04750 ENOG4107RNH Outer membrane receptor FepA HYI42_04765 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) HYI42_04770 ENOG4105E6M Sulphatase-modifying factor protein HYI42_04790 ENOG4105CJ3 phosphate transporter HYI42_04795 ENOG4105C3R Methionine synthase HYI42_04810 ENOG4105CSP Major Facilitator Superfamily HYI42_04820 ENOG4108PZW LysR family Transcriptional regulator HYI42_04830 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HYI42_04835 ENOG4105EU0 Major facilitator Superfamily HYI42_04840 ENOG4108R6W Transcriptional regulator, ARAC family HYI42_04845 ENOG4105CSV Glutaminase HYI42_04850 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HYI42_04855 ENOG4105CSH Transporter HYI42_04865 ENOG4105C7K acetolactate synthase HYI42_04880 ENOG4105CHR reductase HYI42_04885 ENOG4108MXF Alpha Beta Hydrolase HYI42_04895 ENOG4105DJB Major Facilitator Superfamily HYI42_04900 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase HYI42_04910 ENOG4105CHR reductase HYI42_04930 ENOG41069M3 Transcriptional regulator HYI42_04945 ENOG4106YT9 Enoyl-CoA hydratase HYI42_04955 ENOG4105CND Glycosyl transferase, family 2 HYI42_04960 ENOG4107BJW polysaccharide deacetylase HYI42_04970 ENOG4108VWS Yaeq family HYI42_04980 ENOG4105CKI cobalamin synthesis protein HYI42_04990 ENOG4108S4H thioesterase Superfamily protein HYI42_05000 ENOG4105C94 Transporter HYI42_05005 ENOG4105C94 Transporter HYI42_05010 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HYI42_05035 ENOG4107QK5 Homocysteine s-methyltransferase HYI42_05040 ENOG4105D5Q Arginine ornithine antiporter HYI42_05065 ENOG4108YNN Heme oxygenase HYI42_05095 ENOG4108SF5 RNA Polymerase HYI42_05105 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYI42_05110 ENOG4105C54 Major Facilitator superfamily HYI42_05130 ENOG4105F8V Hydrolase, tatD family HYI42_05165 ENOG4108UUM single-stranded DNA-binding protein HYI42_05220 ENOG4105DFP Integrase HYI42_05230 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HYI42_05235 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYI42_05240 ENOG4105CW7 secretion protein, HlyD family HYI42_05245 ENOG4108VUY thioesterase Superfamily protein HYI42_05250 ENOG4105D52 delta-aminolevulinic acid dehydratase HYI42_05255 ENOG4105MWK D-amino acid dehydrogenase, small subunit HYI42_05260 ENOG4105ECP epimerase HYI42_05280 ENOG4107RH8 nuclease SbcCD subunit D HYI42_05285 ENOG4105EYH Exonuclease HYI42_05290 ENOG4105DFA alanine racemase domain protein HYI42_05295 ENOG4105CZX twitching motility protein HYI42_05300 ENOG4105CZX twitching motility protein HYI42_05305 ENOG41090R7 Ferric uptake HYI42_05345 ENOG4107QKV phosphomannomutase HYI42_05355 ENOG4105C4R Atp-dependent dna helicase HYI42_05360 ENOG4108ZG0 Ompa motb domain protein HYI42_05365 ENOG4106HNH Acyl-transferase HYI42_05380 ENOG4107QMS site-determining protein HYI42_05395 ENOG4105CCF Lysine exporter protein (Lyse ygga) HYI42_05400 ENOG4105CNU cell division protein FtsK HYI42_05405 ENOG4105C3M thioredoxin reductase HYI42_05410 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) HYI42_05420 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HYI42_05470 ENOG4108YXA Membrane HYI42_05475 ENOG4105EUB pirin domain protein HYI42_05485 ENOG4105C4K Nad synthetase HYI42_05500 ENOG4105E3J oxidoreductase HYI42_05505 ENOG4105C26 Dehydrogenase HYI42_05510 ENOG4105DVW rieske (2Fe-2S) HYI42_05520 ENOG4105C94 Transporter HYI42_05525 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HYI42_05530 ENOG4105EJC lysr family transcriptional regulator HYI42_05550 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HYI42_05570 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HYI42_05575 ENOG4105C34 Pseudouridine synthase HYI42_05580 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HYI42_05585 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HYI42_05600 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HYI42_05630 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HYI42_05660 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HYI42_05670 ENOG4105DWF phosphomethylpyrimidine kinase HYI42_05675 ENOG4109066 lysm domain bon superfamily protein HYI42_05685 ENOG4105CHR reductase HYI42_05690 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HYI42_05700 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HYI42_05705 ENOG4108BPE -transporting atpase HYI42_05710 ENOG4107RTD sua5 ycio yrdc ywlc family protein HYI42_05715 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HYI42_05720 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HYI42_05725 ENOG4105FE9 pseudouridine synthase HYI42_05735 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HYI42_05740 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HYI42_05750 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HYI42_05760 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HYI42_05765 ENOG4106UW1 Major Facilitator superfamily HYI42_05785 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HYI42_05795 ENOG4105HF0 Membrane HYI42_05810 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HYI42_05820 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HYI42_05870 ENOG4105D1F ATP-binding protein HYI42_05880 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HYI42_05910 ENOG4105K6H D-cysteine desulfhydrase HYI42_05915 ENOG4105CBX hi0933 family HYI42_05940 ENOG4105DP0 ferredoxin-NADP reductase HYI42_05945 ENOG4105DUM transcriptional regulator, lysR family HYI42_05970 ENOG4105C8S subunit m HYI42_05975 ENOG4105D65 subunit l HYI42_05985 ENOG4107UFS subunit j HYI42_06000 ENOG4108IEH NADH dehydrogenase subunit g HYI42_06005 ENOG4107QIZ NADH dehydrogenase HYI42_06010 ENOG4105GKE subunit e HYI42_06030 ENOG4105BZU Histidine kinase HYI42_06040 ENOG4105E0F Histidine kinase HYI42_06045 ENOG4107EXC regulatoR HYI42_06055 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HYI42_06065 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HYI42_06075 ENOG4105JAB phenazine biosynthesis protein, phzf family HYI42_06095 ENOG41082JN Transcriptional regulator HYI42_06100 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HYI42_06135 ENOG4105CH2 amidohydrolase HYI42_06145 ENOG4106P55 Transcriptional regulator HYI42_06160 ENOG4106P55 Transcriptional regulator HYI42_06165 ENOG4107EFR Flavocytochrome c HYI42_06175 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HYI42_06180 ENOG4107RGD Major Facilitator superfamily HYI42_06185 ENOG4105C1G acyl-Coa dehydrogenase HYI42_06190 ENOG4105ETT transcriptional Regulator, LysR family HYI42_06225 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HYI42_06230 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HYI42_06235 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HYI42_06250 ENOG4105VR0 copper resistance HYI42_06255 ENOG4105E3B Multicopper oxidase HYI42_06265 ENOG4108HCJ Hydrolase HYI42_06270 ENOG4105DJV ribulose-phosphate 3-epimerase HYI42_06280 ENOG4105C4W S-formylglutathione hydrolase HYI42_06295 ENOG41072GX Peptidase M22 Glycoprotease HYI42_06300 ENOG4108Z0R Transferase HYI42_06355 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HYI42_06360 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HYI42_06365 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HYI42_06435 ENOG4105K56 Transcriptional regulator HYI42_06440 ENOG4108ZHJ Organic hydroperoxide resistance protein HYI42_06445 ENOG4107QHF type ii secretion system protein e HYI42_06465 ENOG4105C2M dna polymerase I HYI42_06470 ENOG4108VIA integral membrane protein HYI42_06475 ENOG4105II7 pyrroline-5-carboxylate reductase HYI42_06480 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HYI42_06490 ENOG4105C9X ppx gppa phosphatase HYI42_06500 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HYI42_06520 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HYI42_06560 ENOG4105CYM Glutathione S-transferase HYI42_06575 ENOG4105CEY Amp-dependent synthetase and ligase HYI42_06580 ENOG4105N42 UPF0307 protein HYI42_06585 ENOG41080Z8 PHOSPHOCARRIER protein HYI42_06605 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HYI42_06610 ENOG4105DJ0 Poly(A) Polymerase HYI42_06615 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HYI42_06620 ENOG4105DXN mazG family HYI42_06630 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HYI42_06645 ENOG4105C6T cysteine synthase HYI42_06650 ENOG4105BZU Histidine kinase HYI42_06655 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase HYI42_06660 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HYI42_06665 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HYI42_06680 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HYI42_06685 ENOG4105W8H transhydrogenase (subunit alpha HYI42_06690 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HYI42_06695 ENOG4106UX7 integral membrane protein HYI42_06725 ENOG4105E3B Multicopper oxidase HYI42_06740 ENOG4105GR3 Histidine kinase HYI42_06830 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HYI42_06850 ENOG4105CUZ uba thif-type nad fad binding protein HYI42_06855 ENOG4107QM5 aconitate hydratase HYI42_06860 ENOG4105F8V Hydrolase, tatD family HYI42_06875 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HYI42_06895 ENOG4105BZU Histidine kinase HYI42_06905 ENOG4108ZP8 Acetolactate synthase small subunit HYI42_06910 ENOG4105C7K acetolactate synthase HYI42_06935 ENOG4105DJY efflux transporter, rnd family, mfp subunit HYI42_06940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HYI42_06945 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HYI42_06950 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HYI42_06960 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HYI42_06965 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HYI42_06975 ENOG4105VW4 glutaredoxin 3 HYI42_06995 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HYI42_07015 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HYI42_07035 ENOG4105WVQ Fe-S assembly protein IscX HYI42_07050 ENOG4105CN1 protease HYI42_07065 ENOG4106HB6 Alpha beta hydrolase HYI42_07075 ENOG4105C26 Dehydrogenase HYI42_07080 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HYI42_07085 ENOG4105C6Z Gluconate HYI42_07090 ENOG4108UHU Aldolase HYI42_07095 ENOG4105C01 Dihydroxy-acid dehydratase HYI42_07100 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HYI42_07105 ENOG4108DNC Involved in acetate metabolism (By similarity) HYI42_07110 ENOG4107GFK fumarate HYI42_07130 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HYI42_07140 ENOG4108ESX Receptor HYI42_07150 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HYI42_07160 ENOG4105DWV Homoserine O-trans-acetylase HYI42_07240 ENOG4105CHH sulfate transporter HYI42_07255 ENOG4105F6A helicase HYI42_07265 ENOG4108HWY Beta-lactamase HYI42_07340 ENOG4105CIY formyltetrahydrofolate deformylase HYI42_07350 ENOG4107RGH Aldehyde dehydrogenase HYI42_07365 ENOG4105CKD glutathione-regulated potassium-efflux system protein HYI42_07385 ENOG4105VFU Rna-binding protein HYI42_07390 ENOG4105C4R Atp-dependent dna helicase HYI42_07405 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HYI42_07415 ENOG4105KVH Transcriptional regulator HYI42_07445 ENOG4105N14 lysine exporter protein LysE YggA HYI42_07450 ENOG4105D1S lipid A biosynthesis HYI42_07460 ENOG4105CK2 sodium dicarboxylate symporter HYI42_07515 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HYI42_07540 ENOG4105DUM transcriptional regulator, lysR family HYI42_07555 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HYI42_07585 ENOG4105D29 Helix-turn-helix type 11 domain protein HYI42_07590 ENOG4107XGZ Hydrolase HYI42_07595 ENOG4105EI2 Pseudouridine synthase HYI42_07605 ENOG4105C03 ribonuclease HYI42_07610 ENOG4105J5T Amp-dependent synthetase and ligase HYI42_07625 ENOG4105CBN LysR family transcriptional regulator HYI42_07630 ENOG4105EMU Dehydrogenase HYI42_07635 ENOG4105CSA Coproporphyrinogen iii oxidase HYI42_07645 ENOG4107QI1 Mate efflux family protein HYI42_07655 ENOG4107T8P acyl-Coa dehydrogenase HYI42_07685 ENOG4105BZ8 glutamate synthase HYI42_07695 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) HYI42_07700 ENOG4105C5X domain protein HYI42_07715 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HYI42_07725 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HYI42_07735 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HYI42_07740 ENOG4108JU5 Magnesium and cobalt efflux protein HYI42_07745 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HYI42_07750 ENOG4108Z7R Chaperone CsaA HYI42_07760 ENOG4108VAU general secretion pathway protein G HYI42_07765 ENOG4105D7Q type ii secretion system HYI42_07770 ENOG4105C25 Primosomal protein n' HYI42_07775 ENOG4105CKD glutathione-regulated potassium-efflux system protein HYI42_07790 ENOG4105DVC DnaJ domain protein HYI42_07795 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) HYI42_07800 ENOG4107QUT magnesium and cobalt transport protein CorA HYI42_07820 ENOG4107QYX exodeoxyribonuclease v alpha HYI42_07825 ENOG4107QKA exodeoxyribonuclease V beta HYI42_07830 ENOG4105DSY exodeoxyribonuclease V, gamma HYI42_07850 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HYI42_07865 ENOG41061H0 Monooxygenase HYI42_07870 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HYI42_07890 ENOG4108ZE9 Monovalent cation H antiporter subunit C HYI42_07895 ENOG4107R4Z monovalent cation h antiporter subunit d HYI42_07900 ENOG4105SC1 monovalent cation H antiporter subunit E HYI42_07905 ENOG4105W4C monovalent cation H antiporter subunit F HYI42_07910 ENOG4105KJM monovalent cation h antiporter subunit g HYI42_07925 ENOG4105CHV Transcription elongation factor NusA HYI42_07950 ENOG4107EJC Preprotein translocase subunit SecG HYI42_07960 ENOG4107QHF type ii secretion system protein e HYI42_07975 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HYI42_07985 ENOG4105C2N RNA methyltransferase TrmH family group 3 HYI42_08000 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HYI42_08010 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HYI42_08040 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HYI42_08045 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HYI42_08105 ENOG4107ZXU DSBA oxidoreductase HYI42_08120 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HYI42_08135 ENOG4105D3Y Na H antiporter HYI42_08190 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HYI42_08195 ENOG4105PM1 preprotein translocase subunit SecE HYI42_08235 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HYI42_08240 ENOG4105TV9 FHA Domain-Containing protein HYI42_08245 ENOG4105GVR general secretion pathway protein D HYI42_08260 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HYI42_08285 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HYI42_08290 ENOG4108NEV two component transcriptional regulator, LytTR family HYI42_08295 ENOG4108HRK Histidine kinase HYI42_08310 ENOG4108UTW Plays a role in the regulation of phosphate uptake HYI42_08315 ENOG4105DFG type I secretion outer membrane protein HYI42_08320 ENOG4108RNG Permease of the drug metabolite transporter HYI42_08345 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HYI42_08355 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HYI42_08360 ENOG4105CNI cell division protein FtsW HYI42_08375 ENOG4105CE1 Ferrous iron transport protein b HYI42_08385 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HYI42_08390 ENOG4105T95 Thiol disulfide interChange protein HYI42_08395 ENOG4105D6E homoserine dehydrogenase HYI42_08405 ENOG41061WM D-Alanyl-D-Alanine HYI42_08425 ENOG4105CN1 protease HYI42_08430 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HYI42_08435 ENOG4108K5H permease YjgP YjgQ family protein HYI42_08475 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HYI42_08485 ENOG4105BZU Histidine kinase HYI42_08500 ENOG4105C0P Mg chelatase subunit ChlI HYI42_08515 ENOG4105CHH sulfate transporter HYI42_08540 ENOG4105W1Y Transcriptional regulator HYI42_08560 ENOG4108C33 Resolvase HYI42_08615 ENOG4108BUD transposase HYI42_08635 ENOG4108BUD transposase HYI42_08640 ENOG4108C33 Resolvase HYI42_08650 ENOG4108BUD transposase HYI42_08695 ENOG4108KTG Membrane protein, drug metabolite transporter HYI42_08725 ENOG4105XIV Mercuric transport protein, periplasmic component HYI42_08740 ENOG4108X6F Transcriptional regulator MerD HYI42_08760 ENOG4108BUD transposase HYI42_08830 ENOG4105W1Y Transcriptional regulator HYI42_08845 ENOG41082YX Transcriptional regulator, arsr family HYI42_08855 ENOG4105D6J arsenicaL-resistance protein HYI42_08860 ENOG4105CAU Arsenical resistance protein, ArsH HYI42_08865 ENOG4105C3M thioredoxin reductase HYI42_08870 ENOG4105H3G oxidoreductase HYI42_08900 ENOG4105C0P Mg chelatase subunit ChlI HYI42_08905 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYI42_08915 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYI42_08925 ENOG4105EPF Outer membrane porin HYI42_08930 ENOG4105F0N pyrophosphate phospho-hydrolase HYI42_08945 ENOG4105CEY Amp-dependent synthetase and ligase HYI42_08950 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYI42_08955 ENOG41079KZ Major Facilitator Superfamily HYI42_08960 ENOG4105EN6 Membrane HYI42_08965 ENOG4105K5B UPF0225 protein HYI42_08970 ENOG4105EE5 Membrane protein terC HYI42_08975 ENOG4108URH decarboxylase HYI42_08980 ENOG4105C0R drug resistance transporter emrb qaca subfamily HYI42_08990 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HYI42_09005 ENOG4105CCT upf0313 protein HYI42_09025 ENOG4105CS1 NAD(P)H quinone oxidoreductase HYI42_09035 ENOG4105C6T cysteine synthase HYI42_09105 ENOG4105C79 DNA protecting protein DprA HYI42_09120 ENOG4108IND Tetr family transcriptional regulator HYI42_09125 ENOG4107RTG Major Facilitator superfamily HYI42_09135 ENOG4108V06 Glutathione peroxidase HYI42_09200 ENOG4105FDK ABC transporter HYI42_09205 ENOG4105FAV ABC, transporter HYI42_09210 ENOG410829K Lysine exporter protein (Lyse ygga) HYI42_09215 ENOG4105EZR dyp-type peroxidase family protein HYI42_09220 ENOG4107R1I NAD-dependent malic enzyme HYI42_09245 ENOG4105EUB pirin domain protein HYI42_09265 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HYI42_09270 ENOG4106MP8 UPF0754 membrane protein HYI42_09275 ENOG4108VBZ doxx family HYI42_09280 ENOG4105DQR SNARE associated Golgi HYI42_09295 ENOG4107QJE Chromosome Partitioning Protein HYI42_09305 ENOG4107PSF BolA-like protein HYI42_09325 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HYI42_09345 ENOG4107SQU synthase HYI42_09350 ENOG4105C1G acyl-Coa dehydrogenase HYI42_09380 ENOG4105E39 Enoyl-CoA hydratase HYI42_09385 ENOG4105E39 Enoyl-CoA hydratase HYI42_09390 ENOG4105C1G acyl-Coa dehydrogenase HYI42_09400 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HYI42_09405 ENOG4105C26 Dehydrogenase HYI42_09415 ENOG4105C85 amino acid HYI42_09420 ENOG4105C85 amino acid HYI42_09425 ENOG4105M4H endoribonuclease L-psp HYI42_09440 ENOG4105EW9 transcriptional regulator AsnC family HYI42_09465 ENOG4105D3G Pseudouridine synthase HYI42_09480 ENOG4105D5G Transposase HYI42_09505 ENOG4108I0Z Aconitate hydratase HYI42_09510 ENOG4105BZN citrate synthase HYI42_09515 ENOG4105CR4 methylisocitrate lyase HYI42_09520 ENOG4105DRR Transcriptional regulator, GntR family HYI42_09530 ENOG4105CGF Aromatic amino acid aminotransferase HYI42_09535 ENOG4105CXG d-lactate dehydrogenase HYI42_09545 ENOG41073TP transcriptional regulator HYI42_09550 ENOG4105DAA L-lactate HYI42_09555 ENOG4107QKV phosphomannomutase HYI42_09570 ENOG4105C6Y Udp-glucose 6-dehydrogenase HYI42_09575 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HYI42_09590 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HYI42_09595 ENOG4107WZ3 Transferase HYI42_09600 ENOG4105D3Q Sugar transferase HYI42_09630 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HYI42_09635 ENOG4105J5G Transferase hexapeptide repeat containing protein HYI42_09640 ENOG4107R5Z Oxidoreductase domain protein HYI42_09645 ENOG4107QQG Dehydrogenase HYI42_09650 ENOG4105DAY polysaccharide export protein HYI42_09660 ENOG4105D75 Capsular exopolysaccharide family HYI42_09665 ENOG4108V1T peptidylprolyl cis-trans isomerase HYI42_09675 ENOG4105CJR Integral membrane protein (MviN HYI42_09680 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HYI42_09685 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HYI42_09695 ENOG4105HSS phospholipase C HYI42_09725 ENOG41062JF Transcriptional regulator HYI42_09730 ENOG4108Z33 Thiol disulfide Interchange Protein HYI42_09740 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HYI42_09745 ENOG4105UBK short-chain dehydrogenase reductase HYI42_09760 ENOG4107QZM n-acetylglutamate synthase HYI42_09765 ENOG4105GVF (ABC) transporter HYI42_09770 ENOG4105GVF (ABC) transporter HYI42_09775 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HYI42_09780 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HYI42_09785 ENOG4108VM9 ABC, transporter HYI42_09790 ENOG4108R86 Transcriptional regulator HYI42_09795 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HYI42_09805 ENOG4105DTN riboflavin biosynthesis protein ribF HYI42_09810 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HYI42_09820 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HYI42_09860 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HYI42_09920 ENOG4105CVE Lytic murein transglycosylase HYI42_09925 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HYI42_09930 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HYI42_09940 ENOG4105DFU Cell wall formation (By similarity) HYI42_09950 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HYI42_09955 ENOG4105DU1 integral membrane protein, terc HYI42_09965 ENOG4106032 Glutathionylspermidine synthase HYI42_09975 ENOG4107QUY Guanine deaminase HYI42_09980 ENOG4108UGV hypoxanthine phosphoribosyltransferase HYI42_09995 ENOG4105PGM cation diffusion facilitator family transporter HYI42_10010 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HYI42_10035 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HYI42_10045 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYI42_10055 ENOG4105DQR SNARE associated Golgi HYI42_10060 ENOG4105C5H ABC transporter HYI42_10065 ENOG4108821 RND type efflux pump HYI42_10090 ENOG4108821 RND type efflux pump HYI42_10095 ENOG4108821 RND type efflux pump HYI42_10105 ENOG4105D74 hydrolase HYI42_10110 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HYI42_10115 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HYI42_10160 ENOG4105C8J )-transporter HYI42_10170 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HYI42_10195 ENOG4108W5M transcriptional regulator HYI42_10200 ENOG4105C2W permease HYI42_10210 ENOG4108IG5 Transcriptional regulator HYI42_10215 ENOG4105DJY efflux transporter, rnd family, mfp subunit HYI42_10250 ENOG4105F27 Major Facilitator HYI42_10255 ENOG4105CV8 reductase HYI42_10260 ENOG4105HEI LysR family (Transcriptional regulator HYI42_10280 ENOG4105DQ4 alcohol dehydrogenase HYI42_10285 ENOG4108R3E Dna-3-methyladenine glycosylase i HYI42_10300 ENOG4105CEN a g-specific adenine glycosylase HYI42_10320 ENOG4108ZZ3 UPF0260 protein HYI42_10325 ENOG4105D8V Glucose sorbosone dehydrogenase HYI42_10330 ENOG4105D1H recombination factor protein RarA HYI42_10335 ENOG4105S64 Formate nitrite transporter HYI42_10355 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HYI42_10360 ENOG4108RWI nicotinamidase HYI42_10365 ENOG4105C09 Bile acid HYI42_10370 ENOG4107QI1 Mate efflux family protein HYI42_10375 ENOG4105EWC Purine nucleoside phosphorylase HYI42_10405 ENOG4105C85 amino acid HYI42_10415 ENOG4105CKI cobalamin synthesis protein HYI42_10425 ENOG4105CZE histidine utilization repressor HYI42_10430 ENOG41090B9 response to stress HYI42_10445 ENOG4105C85 amino acid HYI42_10455 ENOG41088SP formiminoglutamate hydrolase HYI42_10470 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HYI42_10480 ENOG4105NI8 Cytosine-specific methyltransferase HYI42_10500 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HYI42_10510 ENOG4108ZAI phosphatidylglycerophosphatase a HYI42_10515 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HYI42_10530 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HYI42_10565 ENOG4105KHC sulfurtransferase HYI42_10580 ENOG4105BZU Histidine kinase HYI42_10585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYI42_10600 ENOG4107QJQ Mate efflux family protein HYI42_10605 ENOG4105CHM Aminotransferase HYI42_10610 ENOG4106BRA Membrane HYI42_10625 ENOG4105D9M gamma-glutamylcysteine synthetase HYI42_10665 ENOG4105IPS esterase HYI42_10670 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYI42_10675 ENOG4108Z2U ureidoglycolate hydrolase HYI42_10685 ENOG41061H0 Monooxygenase HYI42_10700 ENOG41084YZ Hydrolase HYI42_10730 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HYI42_10735 ENOG4105BZU Histidine kinase HYI42_10750 ENOG4105KUZ arsenate reductase HYI42_10755 ENOG4105CGK Exodeoxyribonuclease III HYI42_10775 ENOG4105D7Z glutathione synthase HYI42_10795 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HYI42_10800 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HYI42_10805 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HYI42_10820 ENOG41063SB peptidase HYI42_10825 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HYI42_10830 ENOG4107QSN dihydrolipoamide acetyltransferase HYI42_10845 ENOG4105E0K tonB-dependent siderophore receptor HYI42_10860 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HYI42_10875 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HYI42_10895 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYI42_10900 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HYI42_10910 ENOG4105D64 Mechanosensitive ion channel HYI42_10920 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HYI42_10925 ENOG4108W2Y isochorismatase HYI42_10935 ENOG4105FBW Monooxygenase HYI42_10940 ENOG4108UZX fmn reductase HYI42_10955 ENOG4105BZU Histidine kinase HYI42_10960 ENOG41062QD Membrane HYI42_10965 ENOG4107QN1 sodium solute HYI42_10975 ENOG4105C94 Transporter HYI42_10990 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HYI42_10995 ENOG4108WUH Transcriptional regulator, TetR family HYI42_11000 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HYI42_11010 ENOG4105RA2 Membrane HYI42_11015 ENOG4105DWF phosphomethylpyrimidine kinase HYI42_11025 ENOG4107RDB Major Facilitator HYI42_11030 ENOG4108UUM single-stranded DNA-binding protein HYI42_11040 ENOG4108UMN azlc family HYI42_11050 ENOG4105C85 amino acid HYI42_11060 ENOG4108JPW Aminotransferase HYI42_11065 ENOG4105C26 Dehydrogenase HYI42_11075 ENOG4105CHJ isochorismatase hydrolase HYI42_11080 ENOG4105EUB pirin domain protein HYI42_11105 ENOG4105D94 Major Facilitator Superfamily HYI42_11110 ENOG4106NZI LysR family Transcriptional regulator HYI42_11130 ENOG4105CPC Aldo Keto reductase HYI42_11135 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HYI42_11150 ENOG4105KVH Transcriptional regulator HYI42_11165 ENOG4105KVH Transcriptional regulator HYI42_11170 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HYI42_11180 ENOG4108Z9I -acetyltransferase HYI42_11240 ENOG4105CUV Homoserine Kinase HYI42_11280 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HYI42_11305 ENOG4108R6G acetyltransferase HYI42_11310 ENOG4105CYC Transferase HYI42_11320 ENOG4105E0F Histidine kinase HYI42_11330 ENOG4105BZM domain protein HYI42_11335 ENOG4105CHH sulfate transporter HYI42_11340 ENOG4105PDP Short chain dehydrogenase HYI42_11350 ENOG4105C5H ABC transporter HYI42_11415 ENOG4108IQI permease HYI42_11440 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HYI42_11455 ENOG4105CJN penicillin-binding protein HYI42_11460 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HYI42_11465 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HYI42_11480 ENOG4105DHI Methyltransferase HYI42_11485 ENOG4108JQC penicillin-binding protein 1A HYI42_11510 ENOG4105E4G Type IV pilus HYI42_11530 ENOG4105CBC glutamate synthase HYI42_11535 ENOG4105BZ8 glutamate synthase HYI42_11545 ENOG4108V0P LemA family HYI42_11550 ENOG4105HA9 of methanol dehydrogenase type HYI42_11565 ENOG4108YSG O-Antigen polymerase HYI42_11570 ENOG4108UQY Iron-storage protein HYI42_11580 ENOG4105KME endoribonuclease L-psp HYI42_11585 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HYI42_11595 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HYI42_11645 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HYI42_11660 ENOG4107IFA Lipase (EC 3.1.1.3) HYI42_11665 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) HYI42_11670 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HYI42_11695 ENOG4108JQ1 Dehydrogenase HYI42_11700 ENOG4105CQB FAD linked oxidase domain protein HYI42_11710 ENOG4105VRH Antibiotic biosynthesis monooxygenase HYI42_11715 ENOG4105NF4 modulator of drug activity HYI42_11725 ENOG4107QF7 multi-drug HYI42_11730 ENOG4105EM2 membrane HYI42_11735 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HYI42_11740 ENOG4105IPI Membrane HYI42_11745 ENOG4107SKI cobyrinic Acid a,c-diamide synthase HYI42_11775 ENOG4108IQI permease HYI42_11780 ENOG4105D82 Glutamate dehydrogenase HYI42_11785 ENOG4105C8Y Acetylornithine aminotransferase HYI42_11795 ENOG4105C26 Dehydrogenase HYI42_11880 ENOG4105W87 Cbs domain HYI42_11885 ENOG41067S9 phage shock protein C, PspC HYI42_11895 ENOG4105CSU acyl-Coa dehydrogenase HYI42_11910 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) HYI42_11925 ENOG4105ECY inositol monophosphatase HYI42_11930 ENOG4105C1J atp-dependent rna helicase HYI42_11940 ENOG4105DHJ ABC, transporter HYI42_11945 ENOG4105CY3 ABC transporter, permease HYI42_11955 ENOG4105E3I toluene tolerance HYI42_11965 ENOG4105D7N magnesium and cobalt transport protein CorA HYI42_11970 ENOG4108URH decarboxylase HYI42_11980 ENOG4105MJ2 Competence protein HYI42_11985 ENOG4105CB5 ATP-dependent DNA helicase recG HYI42_12005 ENOG4105C29 acyl-CoA thioesterase HYI42_12010 ENOG4105CK2 sodium dicarboxylate symporter HYI42_12025 ENOG4105KPV Transcriptional regulator HYI42_12035 ENOG4105D7A ATP-binding protein HYI42_12045 ENOG41089BK Glutamine amido-transferase HYI42_12155 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HYI42_12195 ENOG4105C1G acyl-Coa dehydrogenase HYI42_12230 ENOG4105VKU nucleicacid-binding protein HYI42_12235 ENOG4105DGW oligopeptidase A HYI42_12240 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HYI42_12285 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HYI42_12290 ENOG4108K2B transcriptional regulator HYI42_12300 ENOG4107S2Z UPF0761 membrane protein HYI42_12305 ENOG4105CS1 NAD(P)H quinone oxidoreductase HYI42_12335 ENOG4105C9A Phoh family HYI42_12345 ENOG4105E4C Lytic transglycosylase catalytic HYI42_12375 ENOG4105D6S protein involved in catabolism of external DNA HYI42_12380 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HYI42_12425 ENOG4105C1G acyl-Coa dehydrogenase HYI42_12430 ENOG4108RZE Tetr family transcriptional regulator HYI42_12445 ENOG4107QX3 carboxylase HYI42_12450 ENOG4105C1G acyl-Coa dehydrogenase HYI42_12470 ENOG4105KB2 stringent starvation protein b HYI42_12475 ENOG4107MKT Stringent starvation protein a HYI42_12480 ENOG4108UJD 30S ribosomal protein S9 HYI42_12490 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HYI42_12495 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HYI42_12500 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HYI42_12520 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HYI42_12530 ENOG4107RZC phospholipase d HYI42_12540 ENOG4105UYK outer membrane protein a HYI42_12545 ENOG4108KHX Diguanylate cyclase HYI42_12580 ENOG4107QN2 dihydrolipoyl dehydrogenase HYI42_12595 ENOG4107U2T alpha beta HYI42_12605 ENOG4105NAU thioesterase Superfamily protein HYI42_12635 ENOG4105K9H YciI-like protein HYI42_12645 ENOG4105DB7 PHP domain protein HYI42_12650 ENOG4105FFC UPF0187 protein HYI42_12660 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HYI42_12665 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HYI42_12670 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HYI42_12675 ENOG4105VIE preprotein translocase, subunit YajC HYI42_12705 ENOG4105BZU Histidine kinase HYI42_12710 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HYI42_12715 ENOG4105CM2 brancheD-chain amino acid aminotransferase HYI42_12730 ENOG4107BJW polysaccharide deacetylase HYI42_12740 ENOG4108PQP glycosyl transferase group 1 HYI42_12780 ENOG4105UGU tonB-dependent Receptor HYI42_12800 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HYI42_12805 ENOG4105CSU acyl-Coa dehydrogenase HYI42_12810 ENOG4105CSU acyl-Coa dehydrogenase HYI42_12820 ENOG4105EB3 Histidine kinase HYI42_12825 ENOG4105E3W Two component transcriptional regulator (Winged helix family HYI42_12830 ENOG4105CNG UPF0061 protein HYI42_12850 ENOG4108WBT adenosyltransferase HYI42_12855 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HYI42_12900 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HYI42_12920 ENOG4105D3R alkyl hydroperoxide reductase HYI42_12935 ENOG4105CSH Transporter HYI42_12940 ENOG4108UT2 hemolysin iii HYI42_12950 ENOG41082BV acetyltransferase HYI42_12970 ENOG4105CHU acetyl-coa acetyltransferase HYI42_12975 ENOG4108R6W Transcriptional regulator, ARAC family HYI42_12985 ENOG4105TW1 Carbohydrate-selective porin OprB HYI42_12990 ENOG4105DZG Dehydrogenase HYI42_12995 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HYI42_13005 ENOG410814C multidrug resistance protein HYI42_13015 ENOG4105CHU acetyl-coa acetyltransferase HYI42_13025 ENOG4108WHA ompa motb domain protein HYI42_13035 ENOG4105E0Y RtcB Protein HYI42_13040 ENOG4108IQI permease HYI42_13050 ENOG4105C2W permease HYI42_13055 ENOG4105CI3 gtp-binding protein typa HYI42_13070 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HYI42_13080 ENOG4108VX5 3-methyladenine DNA glycosylase HYI42_13085 ENOG4105CHB tonB-dependent Receptor HYI42_13090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYI42_13105 ENOG4105T95 Thiol disulfide interChange protein HYI42_13110 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HYI42_13120 ENOG4105K78 MarR family Transcriptional regulator HYI42_13125 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HYI42_13130 ENOG4105KWI UPF0339 protein HYI42_13155 ENOG4108UNF response regulator HYI42_13160 ENOG4105M3Z response regulator HYI42_13165 ENOG4108ZGA chew protein HYI42_13170 ENOG4105C8Q Methyl-accepting chemotaxis HYI42_13175 ENOG4105CBS Chea signal transduction histidine kinase HYI42_13185 ENOG4105D4P Coproporphyrinogen iii oxidase HYI42_13210 ENOG4105WD1 Membrane HYI42_13215 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HYI42_13265 ENOG4105EM2 membrane HYI42_13270 ENOG4105C2C drug resistance transporter, Bcr CflA HYI42_13290 ENOG4105BZG amino acid carrier protein HYI42_13295 ENOG4105D78 K07001 NTE family protein HYI42_13300 ENOG4105C7B Threonine dehydratase HYI42_13330 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HYI42_13340 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HYI42_13350 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HYI42_13355 ENOG4105VQ7 Rod shape-determining protein MreD HYI42_13360 ENOG4108Z03 MAF-like protein HYI42_13365 ENOG4105C03 ribonuclease HYI42_13375 ENOG4105D8T Acyltransferase HYI42_13385 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein HYI42_13395 ENOG4108X0B nad(p)h dehydrogenase (quinone) HYI42_13420 ENOG4105CF7 AraC family transcriptional regulator HYI42_13525 ENOG4105CDU Replicative dna helicase HYI42_13575 ENOG4105MEW serine threonine protein phosphatase HYI42_13740 ENOG4105UPP uncharacterized protein ydcA HYI42_13840 ENOG4105C85 amino acid HYI42_13845 ENOG4105C7F AcnD-accessory protein PrpF HYI42_13850 ENOG4105CTB Polyprenyl synthetase HYI42_13870 ENOG4105D78 K07001 NTE family protein HYI42_13895 ENOG4105XJC Two component transcriptional regulator (Winged helix family HYI42_13900 ENOG4105DHQ Histidine kinase HYI42_13935 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HYI42_13955 ENOG4105K8R UPF0145 protein HYI42_13960 ENOG4105K8R UPF0145 protein HYI42_13965 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HYI42_13970 ENOG4105BZS acriflavin resistance protein HYI42_13975 ENOG4105C1P efflux transporter, rnd family, mfp subunit HYI42_13980 ENOG410841Q phosphoesterase PA-phosphatase related protein HYI42_14010 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HYI42_14025 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HYI42_14030 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HYI42_14035 ENOG4105KVH Transcriptional regulator HYI42_14045 ENOG4105CUB amino acid HYI42_14060 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HYI42_14065 ENOG41084BA UPF0250 protein HYI42_14070 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYI42_14100 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HYI42_14105 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HYI42_14115 ENOG4105E33 succinate dehydrogenase HYI42_14130 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HYI42_14135 ENOG4105C7S Dehydrogenase HYI42_14140 ENOG4107QN2 dihydrolipoyl dehydrogenase HYI42_14150 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HYI42_14170 ENOG4105CKW Inner membrane protein yedI HYI42_14175 ENOG4105CGZ zinc metallopeptidase HYI42_14180 ENOG4105EEQ Na H antiporter HYI42_14260 ENOG41080TK Universal stress protein HYI42_14275 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HYI42_14280 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HYI42_14295 ENOG4105HBR Rna-binding protein HYI42_14305 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HYI42_14310 ENOG4105EEI dihydropteroate synthase HYI42_14360 ENOG4105CSH Transporter HYI42_14365 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HYI42_14370 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HYI42_14385 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HYI42_14410 ENOG41080IJ Diacylglycerol kinase HYI42_14420 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HYI42_14425 ENOG4105BZS acriflavin resistance protein HYI42_14440 ENOG4105E4C Lytic transglycosylase catalytic HYI42_14460 ENOG4108RRZ Transcription elongation factor GreB HYI42_14475 ENOG4105CEY Amp-dependent synthetase and ligase HYI42_14520 ENOG4105BZW Glycerate kinase HYI42_14525 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HYI42_14530 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HYI42_14545 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HYI42_14555 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HYI42_14560 ENOG4105C85 amino acid HYI42_14570 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HYI42_14580 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HYI42_14585 ENOG4105N14 lysine exporter protein LysE YggA HYI42_14590 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HYI42_14595 ENOG4105BZJ Electron transfer flavoprotein HYI42_14600 ENOG4105C10 Electron transfer flavoprotein HYI42_14605 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HYI42_14640 ENOG4107KET secretion protein, HlyD family HYI42_14670 ENOG4105D60 lipoprotein releasing system transmembrane protein HYI42_14675 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HYI42_14680 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HYI42_14690 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HYI42_14695 ENOG4107R6F Alpha Beta Hydrolase Fold protein HYI42_14700 ENOG4108V3E phosphoribosylglycinamide formyltransferase HYI42_14710 ENOG4105C02 permease HYI42_14760 ENOG4105KCK Peptidoglycan-associated lipoprotein HYI42_14765 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) HYI42_14775 ENOG4105M8F Biopolymer transport protein exbD tolR HYI42_14780 ENOG4105E02 MotA TolQ exbB proton channel HYI42_14785 ENOG4107YD3 Thioesterase HYI42_14790 ENOG4105CH2 amidohydrolase HYI42_14810 ENOG4108ETH Formylglycinamide ribotide synthetase HYI42_14815 ENOG4105C2C drug resistance transporter, Bcr CflA HYI42_14825 ENOG4108UKI Enoyl-CoA hydratase HYI42_14840 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HYI42_14855 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HYI42_14860 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HYI42_14875 ENOG4107R11 Transcriptional regulator HYI42_14880 ENOG4108IJ6 ABC transporter HYI42_14890 ENOG4108I5D sulfate abc transporter HYI42_14900 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HYI42_14905 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HYI42_14910 ENOG4105HHA aminodeoxychorismate lyase HYI42_14925 ENOG4108IYU L-aspartate oxidase HYI42_14930 ENOG4105C0H protease HYI42_14945 ENOG4105C3F Signal peptidase i HYI42_14960 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HYI42_14970 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HYI42_14975 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HYI42_14980 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase HYI42_14985 ENOG4105EMU Dehydrogenase HYI42_15025 ENOG4105BZU Histidine kinase HYI42_15035 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HYI42_15045 ENOG4105DTR rard protein HYI42_15080 ENOG4107QS8 (LipO)protein HYI42_15085 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HYI42_15090 ENOG4105EA8 2-Nitropropane dioxygenase HYI42_15120 ENOG4107R8N Glycosyl transferase, family 2 HYI42_15135 ENOG4105CVP deoxyribo-dipyrimidine photolyase HYI42_15140 ENOG4108YZY peptidylprolyl cis-trans isomerase HYI42_15145 ENOG4105CEP NADH dehydrogenase HYI42_15150 ENOG4105DZ1 carboxypeptidase HYI42_15160 ENOG4105E9K Isocitrate dehydrogenase HYI42_15165 ENOG4108R99 pseudouridine synthase HYI42_15185 ENOG4105CBP Major Facilitator HYI42_15190 ENOG4105EGI Transcriptional regulator HYI42_15195 ENOG4108ETY sodium dicarboxylate symporter HYI42_15200 ENOG4105JAB phenazine biosynthesis protein, phzf family HYI42_15235 ENOG4107IIZ CRISPR-associated helicase, Cas3 HYI42_15250 ENOG4105M6W Crispr-associated protein, Csy3 family HYI42_15260 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HYI42_15275 ENOG4105D3G Pseudouridine synthase HYI42_15280 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HYI42_15295 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HYI42_15320 ENOG4108JPW Aminotransferase HYI42_15325 ENOG4105DY8 decarboxylase HYI42_15335 ENOG4105F7P transcriptional regulator AsnC family HYI42_15340 ENOG4107RA9 decarboxylase HYI42_15345 ENOG4105C85 amino acid HYI42_15350 ENOG4105CVA phosphate HYI42_15355 ENOG4105C8U phosphate abc transporter HYI42_15365 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HYI42_15370 ENOG4105ERU peptidase HYI42_15385 ENOG4107QTF adenylosuccinate lyase HYI42_15405 ENOG4108Z0R Transferase HYI42_15410 ENOG4105DZ1 carboxypeptidase HYI42_15430 ENOG4108K5P (LipO)protein HYI42_15435 ENOG4105EJC lysr family transcriptional regulator HYI42_15440 ENOG4105DAN ATP-dependent protease HYI42_15455 ENOG4105DHU Bile acid HYI42_15465 ENOG41066DG (EAL) domain protein HYI42_15475 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HYI42_15485 ENOG4105D22 carbon starvation protein HYI42_15490 ENOG4105VCD cytoplasmic protein HYI42_15500 ENOG4105ETT transcriptional Regulator, LysR family HYI42_15505 ENOG4105H1N peptidase, M24 HYI42_15510 ENOG4105C94 Transporter HYI42_15515 ENOG4105C94 Transporter HYI42_15530 ENOG4107QZF nitrite reductase NADPH large subunit HYI42_15535 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HYI42_15565 ENOG41060M8 Pfam:PhdYeFM HYI42_15595 ENOG4105C2I pirin domain protein HYI42_15605 ENOG4105WWK YheO domain protein HYI42_15620 ENOG4105CEY Amp-dependent synthetase and ligase HYI42_15635 ENOG4108IPW abc transporter atp-binding protein HYI42_15660 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HYI42_15665 ENOG4105WQI isochorismatase HYI42_15675 ENOG4105BZ1 (ABC) transporter HYI42_15710 ENOG4105NX3 Membrane HYI42_15730 ENOG4105EUJ GTP cyclohydrolase i HYI42_15740 ENOG4105C7W Xanthine dehydrogenase HYI42_15770 ENOG4105CD8 aminopeptidase N HYI42_15775 ENOG4105DDQ anthranilate synthase HYI42_15785 ENOG4105DUX Transporter HYI42_15800 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HYI42_15835 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HYI42_15840 ENOG4107QNR UPF0135 protein HYI42_15845 ENOG4105C0H protease HYI42_15855 ENOG4105C6K Malic enzyme HYI42_15870 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HYI42_15875 ENOG4105SYT Methylenetetrahydrofolate reductase HYI42_15880 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HYI42_15895 ENOG4107QPN acyl-Coa dehydrogenase HYI42_15900 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HYI42_15905 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) HYI42_15915 ENOG4107RNU major facilitator superfamily MFS_1 HYI42_15925 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HYI42_15930 ENOG4105CE9 30S ribosomal protein S2 HYI42_15970 ENOG4105CVE Lytic murein transglycosylase HYI42_15975 ENOG4105CNI cell division protein FtsW HYI42_15990 ENOG4105E3A (ABC) transporter HYI42_15995 ENOG4105DA5 (ABC) transporter HYI42_16040 ENOG41076J9 exonuclease VIII HYI42_16100 ENOG4105CDU Replicative dna helicase HYI42_16320 ENOG4105DR5 peptidase HYI42_16405 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HYI42_16415 ENOG4105ENT Efflux transporter rnd family, mfp subunit HYI42_16425 ENOG4105E89 ABC transporter HYI42_16430 ENOG4105DSP amino acid AbC transporter HYI42_16435 ENOG4106YG3 ABC transporter HYI42_16450 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HYI42_16455 ENOG4105CFP Peptidase U32 HYI42_16460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HYI42_16465 ENOG4105JAB phenazine biosynthesis protein, phzf family HYI42_16470 ENOG4105DP0 ferredoxin-NADP reductase HYI42_16475 ENOG4108R96 Methyltransferase, YaeB family HYI42_16485 ENOG4107QHF type ii secretion system protein e HYI42_16495 ENOG4105XJC Two component transcriptional regulator (Winged helix family HYI42_16500 ENOG4105DHQ Histidine kinase HYI42_16510 ENOG4105M6F mutator MutT protein HYI42_16525 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HYI42_16530 ENOG4105VUT cytoplasmic protein HYI42_16535 ENOG4107QYG anthranilate phosphoribosyltransferase HYI42_16540 ENOG4105CK2 sodium dicarboxylate symporter HYI42_16545 ENOG4105C1G acyl-Coa dehydrogenase HYI42_16550 ENOG4105NIV Esterase HYI42_16555 ENOG4105CQC Prephenate dehydratase HYI42_16560 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HYI42_16570 ENOG4105CIN aminoacyl-histidine dipeptidase HYI42_16575 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HYI42_16600 ENOG4105M08 Membrane HYI42_16605 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HYI42_16615 ENOG4105VEQ Cold shock protein HYI42_16620 ENOG4105C1J atp-dependent rna helicase HYI42_16630 ENOG41069NU Nitroreductase HYI42_16665 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HYI42_16680 ENOG4105C5I Dehydrogenase HYI42_16685 ENOG4105ERG peptidase m48, ste24p HYI42_16690 ENOG4105KTH gatB Yqey HYI42_16745 ENOG4105EVZ LysR family transcriptional regulator HYI42_16750 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HYI42_16755 ENOG4105C26 Dehydrogenase HYI42_16790 ENOG4105H4F exported protein HYI42_16820 ENOG4105D6U Sodium Glutamate Symporter HYI42_16830 ENOG4107RSM transcriptional regulator HYI42_16840 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HYI42_16855 ENOG4105JXH GntR family transcriptional regulator HYI42_16915 ENOG4105CSH Transporter HYI42_16940 ENOG4105F1S paraquat-inducible protein a HYI42_16945 ENOG4105DY2 Paraquat-inducible protein b HYI42_16955 ENOG4105VT2 5-hydroxyisourate hydrolase HYI42_17005 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HYI42_17010 ENOG4105DHQ Histidine kinase HYI42_17015 ENOG4105ETX regulatoR HYI42_17065 ENOG4105CK2 sodium dicarboxylate symporter HYI42_17075 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HYI42_17080 ENOG4108UMI ABC transporter, permease HYI42_17085 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HYI42_17095 ENOG4105C12 Phosphoribosylglycinamide synthetase HYI42_17100 ENOG4105DC1 bifunctional purine biosynthesis protein purh HYI42_17105 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HYI42_17155 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HYI42_17160 ENOG4105CDU Replicative dna helicase HYI42_17185 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HYI42_17190 ENOG4105CCU oxidase (Subunit III) HYI42_17195 ENOG4105BZ9 Cytochrome C oxidase, subunit I HYI42_17200 ENOG4105E2S oxidase) subunit II HYI42_17230 ENOG4105CND Glycosyl transferase, family 2 HYI42_17245 ENOG4105DEN Luciferase family HYI42_17260 ENOG4105CC0 LysR family Transcriptional regulator HYI42_17275 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HYI42_17280 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HYI42_17285 ENOG4105GVF (ABC) transporter HYI42_17300 ENOG4105C1G acyl-Coa dehydrogenase HYI42_17310 ENOG4108MEJ flavin reductase domain protein HYI42_17315 ENOG4105D06 uba thif-type nad fad binding protein HYI42_17335 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HYI42_17340 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HYI42_17355 ENOG4105EEX Two component transcriptional regulator (Winged helix family HYI42_17375 ENOG4107S74 Lysophospholipid transporter LplT HYI42_17380 ENOG4105CFU surface antigen HYI42_17395 ENOG4107QIJ Aconitate hydratase 2 HYI42_17405 ENOG4105EYW Ion transport protein HYI42_17410 ENOG4105F27 Major Facilitator HYI42_17425 ENOG4105DZ2 Transcriptional regulator HYI42_17460 ENOG4105K8N protein family UPF0079, ATPase HYI42_17465 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HYI42_17480 ENOG4108TZV Membrane HYI42_17485 ENOG4108RCM Nitroreductase HYI42_17505 ENOG4105CX6 glutaminyL-tRNA synthetase HYI42_17510 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HYI42_17515 ENOG4107FQ9 ethanolamine ammonia-lyase HYI42_17520 ENOG4105CPD ethanolamine ammonia-lyase HYI42_17525 ENOG4107R55 ethanolamine transporter HYI42_17535 ENOG4107RR1 TRANSCRIPTIONal HYI42_17545 ENOG4105C0A alcohol dehydrogenase HYI42_17550 ENOG4107QUV Domain protein HYI42_17575 ENOG4105CD8 aminopeptidase N HYI42_17615 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) HYI42_17620 ENOG4105EW9 transcriptional regulator AsnC family HYI42_17640 ENOG4105R8C Transcriptional regulator HYI42_17650 ENOG4105CUY Mechanosensitive ion channel HYI42_17700 ENOG4105C5H ABC transporter HYI42_17705 ENOG41081QV Universal stress protein HYI42_17770 ENOG4105DKK Benzoate HYI42_17775 ENOG4105EW9 transcriptional regulator AsnC family HYI42_17780 ENOG4108NIW Leucine export protein LeuE HYI42_17790 ENOG4105C5Q Transcriptional regulator HYI42_17800 ENOG4105CHU acetyl-coa acetyltransferase HYI42_17805 ENOG4105CHR reductase HYI42_17830 ENOG4107QMP dna polymerase iii subunits gamma and tau HYI42_17835 ENOG4105HSS phospholipase C HYI42_17845 ENOG4105C0A alcohol dehydrogenase HYI42_17875 ENOG4105CBC glutamate synthase HYI42_17905 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HYI42_17910 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HYI42_17935 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYI42_17945 ENOG4107QZF nitrite reductase NADPH large subunit HYI42_17950 ENOG4108IFG nitrite reductase, (NAD(P)H) HYI42_17985 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HYI42_17990 ENOG4105CVM Molybdenum cofactor synthesis domain protein HYI42_18005 ENOG4105T38 integral membrane protein HYI42_18025 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HYI42_18030 ENOG4105CMR udp-glucose 4-epimerase HYI42_18085 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HYI42_18090 ENOG4105CUX Signal transduction histidine kinase HYI42_18115 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HYI42_18120 ENOG4105KNE Phosphatidate cytidylyltransferase HYI42_18155 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HYI42_18170 ENOG4105Y3E Modulates RecA activity (By similarity) HYI42_18180 ENOG4105VEJ Heat shock protein HYI42_18185 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HYI42_18220 ENOG4105C85 amino acid HYI42_18235 ENOG4105CHH sulfate transporter HYI42_18240 ENOG4108RAV Conserved protein HYI42_18245 ENOG4105D8V Glucose sorbosone dehydrogenase HYI42_18255 ENOG4105BZU Histidine kinase HYI42_18275 ENOG4105DM4 PTS System HYI42_18280 ENOG4105DE4 1-phosphofructokinase HYI42_18285 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HYI42_18310 ENOG4105CWM branched-chain amino acid transport system II carrier protein HYI42_18315 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HYI42_18330 ENOG4105M2J Glutaredoxin HYI42_18335 ENOG4105C8Y Acetylornithine aminotransferase HYI42_18340 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HYI42_18365 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HYI42_18375 ENOG41068P6 UPF0319 protein HYI42_18390 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HYI42_18395 ENOG4105C4M (Ubiquinol oxidase) subunit I HYI42_18405 ENOG4105PV3 Inner membrane protein yqiJ HYI42_18430 ENOG4105HDD phospholipase HYI42_18435 ENOG4105CZN Potassium uptake protein HYI42_18445 ENOG4105C7B Threonine dehydratase HYI42_18475 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HYI42_18480 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HYI42_18490 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HYI42_18505 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYI42_18550 ENOG4107VMU Membrane HYI42_18555 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HYI42_18565 ENOG4107QP7 CoA-transferase subunit A HYI42_18570 ENOG4107QNJ CoA-transferase subunit B HYI42_18575 ENOG4105CHU acetyl-coa acetyltransferase HYI42_18580 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HYI42_18585 ENOG4105F2Z 3-oxoadipate enol-lactonase HYI42_18590 ENOG4105D2S major facilitator superfamily HYI42_18595 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HYI42_18600 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HYI42_18605 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HYI42_18610 ENOG4105FF2 Type I DHQase HYI42_18615 ENOG4106JPM 3-dehydroshikimate dehydratase HYI42_18620 ENOG4105TW1 Carbohydrate-selective porin OprB HYI42_18625 ENOG4105DZG Dehydrogenase HYI42_18635 ENOG4105MD1 YeeE YedE family protein HYI42_18650 ENOG4107HP6 Transcriptional regulator HYI42_18655 ENOG4108PTX LysR family Transcriptional regulator HYI42_18660 ENOG4105C1G acyl-Coa dehydrogenase HYI42_18685 ENOG4105DNH Major Facilitator HYI42_18695 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HYI42_18715 ENOG4105FUY alpha subunit HYI42_18725 ENOG4105CHR reductase HYI42_18745 ENOG4105F11 amine oxidase HYI42_18755 ENOG4105C26 Dehydrogenase HYI42_18765 ENOG4105F2Z 3-oxoadipate enol-lactonase HYI42_18770 ENOG4105CHU acetyl-coa acetyltransferase HYI42_18775 ENOG4107QNJ CoA-transferase subunit B HYI42_18780 ENOG4107QP7 CoA-transferase subunit A HYI42_18790 ENOG4105NN7 muconolactone delta-isomerase HYI42_18795 ENOG4105DTQ mandelate racemase muconate lactonizing HYI42_18800 ENOG4108KB2 LysR family Transcriptional regulator HYI42_18810 ENOG4107EJG GntR family transcriptional regulator HYI42_18830 ENOG4105CZJ Aldehyde dehydrogenase HYI42_18845 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYI42_18885 ENOG4107Z3H Transcriptional regulator, TetR family HYI42_18895 ENOG4105EMU Dehydrogenase HYI42_18900 ENOG4107GD3 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide (By similarity) HYI42_18910 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HYI42_18930 ENOG4105CHJ isochorismatase hydrolase HYI42_18935 ENOG4105EJC lysr family transcriptional regulator HYI42_18940 ENOG4105D8V Glucose sorbosone dehydrogenase HYI42_18945 ENOG4105CKD glutathione-regulated potassium-efflux system protein HYI42_18955 ENOG4105CH2 amidohydrolase HYI42_19030 ENOG4106P55 Transcriptional regulator HYI42_19045 ENOG4105CW7 secretion protein, HlyD family HYI42_19060 ENOG4105CZJ Aldehyde dehydrogenase HYI42_19075 ENOG4105DDW LysR family Transcriptional regulator HYI42_19080 ENOG4105EXW epimerase dehydratase HYI42_19090 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HYI42_19105 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HYI42_19165 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HYI42_19215 ENOG4105ENX hydrolase HYI42_19220 ENOG4105EQ2 LysR family Transcriptional regulator HYI42_19225 ENOG4108BAS reductase HYI42_19240 ENOG4108R6W Transcriptional regulator, ARAC family HYI42_19250 ENOG4105E0F Histidine kinase HYI42_19255 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HYI42_19260 ENOG4105C1P efflux transporter, rnd family, mfp subunit HYI42_19265 ENOG4105BZS acriflavin resistance protein HYI42_19270 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HYI42_19280 ENOG4105CT3 Monooxygenase HYI42_19290 ENOG4105CJP fad dependent oxidoreductase HYI42_19495 ENOG4105UGU tonB-dependent Receptor