locus-tag	class	description
HYI42_00060	COG3539	Fimbrial protein
HYI42_00085	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HYI42_00095	COG0753	catalase activity
HYI42_00110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYI42_00115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYI42_00180	COG1535	isochorismatase
HYI42_00180	COG3433	isochorismatase activity
HYI42_00185	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_00195	COG4149	molybdate abc transporter
HYI42_00200	COG0725	ABC transporter, periplasmic molybdate-binding protein
HYI42_00210	COG4638	Rieske (2fe-2S)
HYI42_00215	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HYI42_00220	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYI42_00220	COG0543	2 iron, 2 sulfur cluster binding
HYI42_00240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYI42_00250	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_00270	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_00275	COG2610	gluconate transmembrane transporter activity
HYI42_00300	COG2031	fatty acid transporter
HYI42_00305	COG0183	Belongs to the thiolase family
HYI42_00310	COG0583	DNA-binding transcription factor activity
HYI42_00330	COG1027	Aspartate ammonia-lyase
HYI42_00340	COG0477	Major facilitator Superfamily
HYI42_00360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYI42_00365	COG4521	taurine ABC transporter
HYI42_00380	COG2188	Transcriptional regulator
HYI42_00390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HYI42_00395	COG1733	regulation of RNA biosynthetic process
HYI42_00400	COG3708	Transcriptional regulator
HYI42_00400	COG2207	Transcriptional regulator
HYI42_00415	COG0730	response to heat
HYI42_00425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYI42_00425	COG3453	Protein conserved in bacteria
HYI42_00435	COG3781	membrane
HYI42_00440	COG1063	alcohol dehydrogenase
HYI42_00450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYI42_00455	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYI42_00460	COG0022	dehydrogenase e1 component
HYI42_00465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HYI42_00470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYI42_00485	COG3706	GGDEF domain
HYI42_00500	COG0133	tryptophan synthase activity
HYI42_00510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYI42_00545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HYI42_00570	COG2226	methyltransferase
HYI42_00625	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYI42_00630	COG4773	Receptor
HYI42_00650	COG0730	response to heat
HYI42_00655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HYI42_00670	COG0406	alpha-ribazole phosphatase activity
HYI42_00675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HYI42_00690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYI42_00720	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYI42_00730	COG4264	IucA IucC family
HYI42_00735	COG4264	IucA IucC family
HYI42_00740	COG2814	Major facilitator Superfamily
HYI42_00755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HYI42_00770	COG1960	acyl-CoA dehydrogenase activity
HYI42_00775	COG1960	acyl-CoA dehydrogenase activity
HYI42_00780	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYI42_00785	COG2207	Transcriptional regulator
HYI42_00790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYI42_00795	COG0776	regulation of translation
HYI42_00820	COG0822	iron-sulfur transferase activity
HYI42_00825	COG0316	Belongs to the HesB IscA family
HYI42_00865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HYI42_00885	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HYI42_00925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HYI42_00935	COG0339	signal peptide processing
HYI42_00955	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HYI42_00980	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HYI42_00985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HYI42_01015	COG0776	regulation of translation
HYI42_01080	COG0084	hydrolase, TatD family'
HYI42_01100	COG1663	tetraacyldisaccharide 4'-kinase activity
HYI42_01105	COG1132	(ABC) transporter
HYI42_01115	COG0811	peptide transport
HYI42_01120	COG1475	DNA binding
HYI42_01125	COG1192	Involved in chromosome partitioning
HYI42_01135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HYI42_01150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HYI42_01155	COG0191	fructose-bisphosphate aldolase activity
HYI42_01175	COG0424	maF-like protein
HYI42_01180	COG2850	peptidyl-arginine hydroxylation
HYI42_01190	COG0640	Transcriptional regulator
HYI42_01200	COG3619	membrane
HYI42_01205	COG3122	Protein conserved in bacteria
HYI42_01230	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HYI42_01235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYI42_01245	COG0506	proline dehydrogenase activity
HYI42_01245	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HYI42_01245	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HYI42_01275	COG2353	YceI-like domain
HYI42_01285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HYI42_01330	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HYI42_01330	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HYI42_01355	COG3539	Fimbrial protein
HYI42_01385	COG0697	spore germination
HYI42_01395	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYI42_01405	COG0583	DNA-binding transcription factor activity
HYI42_01440	COG1522	sequence-specific DNA binding
HYI42_01450	COG1126	abc transporter atp-binding protein
HYI42_01455	COG0765	amino acid transport
HYI42_01460	COG0765	amino acid transport
HYI42_01490	COG1464	Belongs to the NlpA lipoprotein family
HYI42_01500	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYI42_01505	COG2011	ABC-type metal ion transport system permease component
HYI42_01510	COG0012	GTP binding
HYI42_01535	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HYI42_01575	COG0386	Belongs to the glutathione peroxidase family
HYI42_01585	COG0436	Aminotransferase
HYI42_01590	COG1301	dicarboxylic acid transport
HYI42_01625	COG3634	alkyl hydroperoxide reductase activity
HYI42_01640	COG0583	DNA-binding transcription factor activity
HYI42_01645	COG0798	PFAM Bile acid sodium symporter
HYI42_01650	COG0640	Transcriptional regulator
HYI42_01665	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HYI42_01685	COG1953	Uracil, thiamine, allantoin
HYI42_01695	COG2175	clavaminate synthase activity
HYI42_01700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYI42_01705	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HYI42_01710	COG4521	taurine ABC transporter
HYI42_01720	COG0477	Major facilitator Superfamily
HYI42_01740	COG1271	oxidase subunit
HYI42_01745	COG1294	oxidase, subunit
HYI42_01755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYI42_01775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HYI42_01795	COG3052	prosthetic group binding
HYI42_01800	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HYI42_01810	COG2814	Major facilitator Superfamily
HYI42_01825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYI42_01830	COG1346	cytolysis
HYI42_01840	COG0583	DNA-binding transcription factor activity
HYI42_01845	COG0625	glutathione transferase activity
HYI42_01850	COG0625	glutathione transferase activity
HYI42_01855	COG0583	DNA-binding transcription factor activity
HYI42_01870	COG1045	serine acetyltransferase
HYI42_01875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYI42_01880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HYI42_01885	COG1280	lysine exporter protein (LysE YggA)
HYI42_01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYI42_01905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYI42_01910	COG1126	abc transporter atp-binding protein
HYI42_01915	COG0765	amino acid transport
HYI42_01920	COG0765	amino acid transport
HYI42_01940	COG0784	Response regulator, receiver
HYI42_01940	COG2205	protein histidine kinase activity
HYI42_02030	COG0583	DNA-binding transcription factor activity
HYI42_02050	COG0318	PFAM AMP-dependent synthetase and ligase
HYI42_02055	COG1309	transcriptional regulator
HYI42_02060	COG1960	acyl-CoA dehydrogenase activity
HYI42_02065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYI42_02070	COG1024	Enoyl-CoA hydratase
HYI42_02075	COG4770	biotin carboxylase activity
HYI42_02085	COG0583	DNA-binding transcription factor activity
HYI42_02100	COG1960	acyl-CoA dehydrogenase activity
HYI42_02110	COG2814	Major facilitator Superfamily
HYI42_02120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HYI42_02125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYI42_02130	COG2814	Major facilitator Superfamily
HYI42_02135	COG1960	acyl-CoA dehydrogenase activity
HYI42_02140	COG1024	Enoyl-CoA hydratase
HYI42_02145	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_02150	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYI42_02155	COG0183	Belongs to the thiolase family
HYI42_02165	COG2814	Major facilitator Superfamily
HYI42_02175	COG1024	Enoyl-CoA hydratase
HYI42_02185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYI42_02190	COG1960	acyl-CoA dehydrogenase activity
HYI42_02195	COG2814	Major facilitator Superfamily
HYI42_02200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HYI42_02205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HYI42_02220	COG3842	ATPase activity
HYI42_02225	COG1840	ABC-type Fe3 transport system, periplasmic component
HYI42_02235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYI42_02240	COG1414	Transcriptional regulator
HYI42_02250	COG0583	DNA-binding transcription factor activity
HYI42_02255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYI42_02260	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_02270	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HYI42_02280	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_02285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYI42_02290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYI42_02295	COG2267	carboxylic ester hydrolase activity
HYI42_02315	COG3038	cytochrome b561
HYI42_02320	COG0753	catalase activity
HYI42_02330	COG2271	Major facilitator Superfamily
HYI42_02335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYI42_02340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYI42_02410	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HYI42_02415	COG2050	protein possibly involved in aromatic compounds catabolism
HYI42_02425	COG3327	negative regulation of DNA-templated transcription, initiation
HYI42_02430	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HYI42_02435	COG0183	Belongs to the thiolase family
HYI42_02440	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYI42_02445	COG1024	Enoyl-CoA hydratase
HYI42_02450	COG1024	Enoyl-CoA hydratase
HYI42_02455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYI42_02460	COG2151	metal-sulfur cluster biosynthetic enzyme
HYI42_02465	COG3396	Phenylacetate-CoA oxygenase
HYI42_02470	COG3460	Phenylacetate-CoA oxygenase
HYI42_02475	COG3396	Phenylacetate-CoA oxygenase
HYI42_02480	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_02480	COG2030	dehydratase
HYI42_02485	COG1760	l-serine dehydratase
HYI42_02490	COG0531	amino acid
HYI42_02495	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_02520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYI42_02540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYI42_02550	COG0789	Transcriptional regulator
HYI42_02560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HYI42_02575	COG2807	transmembrane transport
HYI42_02580	COG0590	tRNA wobble adenosine to inosine editing
HYI42_02695	COG1116	anion transmembrane transporter activity
HYI42_02700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HYI42_02710	COG0864	Transcriptional regulator
HYI42_02720	COG1733	regulation of RNA biosynthetic process
HYI42_02725	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYI42_02730	COG0439	Biotin carboxylase
HYI42_02745	COG1063	alcohol dehydrogenase
HYI42_02755	COG1309	transcriptional regulator
HYI42_02780	COG0038	chloride channel
HYI42_02785	COG4770	biotin carboxylase activity
HYI42_02805	COG1914	H( )-stimulated, divalent metal cation uptake system
HYI42_02810	COG0583	DNA-binding transcription factor activity
HYI42_02840	COG3209	COG3209 Rhs family protein
HYI42_02845	COG3501	Rhs element vgr protein
HYI42_02870	COG1250	3-hydroxyacyl-CoA dehydrogenase
HYI42_02900	COG1560	Kdo2-lipid A biosynthetic process
HYI42_02910	COG5006	permease, DMT superfamily
HYI42_02915	COG1522	sequence-specific DNA binding
HYI42_02930	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HYI42_02940	COG4122	O-methyltransferase activity
HYI42_02970	COG1538	Outer membrane efflux protein
HYI42_02975	COG1137	ATPase activity
HYI42_02980	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HYI42_02990	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HYI42_03065	COG3566	protein conserved in bacteria
HYI42_03085	COG3567	Phage-associated protein, HI1409 family
HYI42_03090	COG5410	chromosome segregation
HYI42_03160	COG2814	Major facilitator Superfamily
HYI42_03195	COG1278	Cold shock
HYI42_03230	COG1570	exodeoxyribonuclease VII activity
HYI42_03280	COG0583	DNA-binding transcription factor activity
HYI42_03285	COG4638	Rieske (2fe-2S)
HYI42_03290	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HYI42_03295	COG0543	2 iron, 2 sulfur cluster binding
HYI42_03295	COG0633	Ferredoxin
HYI42_03300	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_03305	COG3135	benzoate transporter
HYI42_03310	COG2814	Major facilitator Superfamily
HYI42_03325	COG1643	Atp-dependent helicase
HYI42_03330	COG0450	alkyl hydroperoxide reductase
HYI42_03340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HYI42_03350	COG3634	alkyl hydroperoxide reductase activity
HYI42_03370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HYI42_03375	COG0625	glutathione transferase activity
HYI42_03385	COG2885	chlorophyll binding
HYI42_03420	COG0542	response to heat
HYI42_03435	COG1765	OsmC-like protein
HYI42_03445	COG0667	Aldo Keto reductase
HYI42_03460	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HYI42_03470	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HYI42_03575	COG0592	DNA-directed DNA polymerase activity
HYI42_03785	COG1484	DNA-dependent DNA replication
HYI42_03865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYI42_03905	COG0527	aspartate kinase activity
HYI42_03915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HYI42_03925	COG3038	cytochrome b561
HYI42_03930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HYI42_03935	COG2252	PERMEase
HYI42_03945	COG2072	flavoprotein involved in K transport
HYI42_03960	COG1741	Belongs to the pirin family
HYI42_03975	COG0300	oxidoreductase activity
HYI42_03980	COG2072	flavoprotein involved in K transport
HYI42_03985	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HYI42_04030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYI42_04045	COG2814	Major facilitator Superfamily
HYI42_04050	COG1024	Enoyl-CoA hydratase
HYI42_04055	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_04065	COG1960	acyl-CoA dehydrogenase activity
HYI42_04090	COG2186	Transcriptional regulator
HYI42_04095	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_04105	COG4948	Mandelate Racemase Muconate Lactonizing
HYI42_04110	COG2271	Major facilitator Superfamily
HYI42_04115	COG2721	sulfolactate sulfo-lyase activity
HYI42_04120	COG0697	spore germination
HYI42_04150	COG1113	amino acid transport
HYI42_04170	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_04190	COG0531	amino acid
HYI42_04200	COG1113	amino acid transport
HYI42_04235	COG3209	COG3209 Rhs family protein
HYI42_04240	COG3501	Rhs element vgr protein
HYI42_04265	COG1902	pentaerythritol trinitrate reductase activity
HYI42_04265	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYI42_04275	COG2203	Gaf domain
HYI42_04275	COG3706	GGDEF domain
HYI42_04275	COG4251	negative regulation of phosphorylation
HYI42_04275	COG5001	Diguanylate cyclase
HYI42_04285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYI42_04345	COG4172	Belongs to the ABC transporter superfamily
HYI42_04350	COG4239	(ABC) transporter, permease
HYI42_04355	COG4174	ABC transporter (Permease)
HYI42_04365	COG0741	lytic transglycosylase activity
HYI42_04365	COG1388	LysM domain
HYI42_04365	COG1388	LysM domain
HYI42_04365	COG0741	lytic transglycosylase activity
HYI42_04370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYI42_04410	COG0583	DNA-binding transcription factor activity
HYI42_04415	COG1279	arginine transmembrane transporter activity
HYI42_04435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYI42_04440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYI42_04445	COG0006	proline dipeptidase activity
HYI42_04505	COG3384	dioxygenase
HYI42_04515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYI42_04520	COG2878	Part of a membrane complex involved in electron transport
HYI42_04525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HYI42_04550	COG0768	penicillin binding
HYI42_04555	COG0742	ribosomal rna small subunit methyltransferase
HYI42_04570	COG0830	nickel cation binding
HYI42_04580	COG0804	urea catabolic process
HYI42_04620	COG1253	flavin adenine dinucleotide binding
HYI42_04625	COG2851	Citrate transporter
HYI42_04675	COG1773	rubredoxin
HYI42_04680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYI42_04690	COG0583	DNA-binding transcription factor activity
HYI42_04720	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HYI42_04725	COG4181	ATPase activity
HYI42_04770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HYI42_04790	COG0306	phosphate transporter
HYI42_04800	COG3958	Transketolase
HYI42_04805	COG3959	Transketolase, thiamine diphosphate binding domain
HYI42_04810	COG2271	Major facilitator Superfamily
HYI42_04815	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_04820	COG0583	DNA-binding transcription factor activity
HYI42_04835	COG2223	nitrite transmembrane transporter activity
HYI42_04840	COG2207	Transcriptional regulator
HYI42_04845	COG2066	Belongs to the glutaminase family
HYI42_04850	COG0242	peptide deformylase activity
HYI42_04855	COG0477	Major facilitator Superfamily
HYI42_04865	COG0028	Belongs to the TPP enzyme family
HYI42_04880	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_04885	COG2267	carboxylic ester hydrolase activity
HYI42_04895	COG2271	Major facilitator Superfamily
HYI42_04900	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYI42_04910	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_04930	COG1414	Transcriptional regulator
HYI42_04945	COG1024	Enoyl-CoA hydratase
HYI42_04955	COG1215	transferase activity, transferring glycosyl groups
HYI42_04960	COG1649	PFAM Uncharacterised BCR, COG1649
HYI42_04960	COG0726	polysaccharide deacetylase
HYI42_04970	COG4681	YaeQ
HYI42_04980	COG0523	cobalamin synthesis protein
HYI42_04990	COG1607	acyl-coa hydrolase
HYI42_05000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYI42_05005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYI42_05010	COG1309	transcriptional regulator
HYI42_05035	COG2040	homocysteine
HYI42_05040	COG0531	amino acid
HYI42_05095	COG1595	DNA-templated transcription, initiation
HYI42_05105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYI42_05110	COG0477	Major facilitator Superfamily
HYI42_05130	COG0084	hydrolase, TatD family'
HYI42_05165	COG0629	single-stranded DNA binding
HYI42_05220	COG0582	viral genome integration into host DNA
HYI42_05230	COG0405	Gamma-glutamyltransferase
HYI42_05235	COG2814	Major facilitator Superfamily
HYI42_05245	COG2050	protein possibly involved in aromatic compounds catabolism
HYI42_05260	COG1090	epimerase
HYI42_05280	COG0420	3'-5' exonuclease activity
HYI42_05305	COG0735	belongs to the Fur family
HYI42_05310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HYI42_05345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYI42_05355	COG0210	DNA helicase
HYI42_05360	COG2885	chlorophyll binding
HYI42_05365	COG0204	Acyl-transferase
HYI42_05380	COG2894	cell division
HYI42_05395	COG1280	lysine exporter protein (LysE YggA)
HYI42_05400	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HYI42_05400	COG1674	ftsk spoiiie
HYI42_05405	COG0492	ferredoxin-NADP+ reductase activity
HYI42_05410	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HYI42_05420	COG0456	acetyltransferase
HYI42_05485	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HYI42_05485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYI42_05505	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_05525	COG0473	3-isopropylmalate dehydrogenase activity
HYI42_05530	COG0583	DNA-binding transcription factor activity
HYI42_05550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYI42_05575	COG0564	pseudouridine synthase activity
HYI42_05585	COG0358	DNA primase activity
HYI42_05600	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HYI42_05630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYI42_05660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HYI42_05670	COG0351	phosphomethylpyrimidine kinase
HYI42_05670	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HYI42_05670	COG0352	thiamine-phosphate diphosphorylase activity
HYI42_05675	COG1652	LysM domain
HYI42_05700	COG1399	metal-binding, possibly nucleic acid-binding protein
HYI42_05705	COG3101	peptidyl-lysine hydroxylation
HYI42_05710	COG0009	L-threonylcarbamoyladenylate synthase
HYI42_05715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HYI42_05720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HYI42_05735	COG4106	trans-aconitate 2-methyltransferase activity
HYI42_05750	COG2226	methyltransferase
HYI42_05750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYI42_05750	COG0596	Alpha beta hydrolase
HYI42_05760	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HYI42_05765	COG2223	nitrite transmembrane transporter activity
HYI42_05785	COG1196	nuclear chromosome segregation
HYI42_05795	COG0730	response to heat
HYI42_05810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HYI42_05820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYI42_05870	COG0489	protein tyrosine kinase activity
HYI42_05880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYI42_05880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYI42_05910	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HYI42_05915	COG2081	HI0933 family
HYI42_05925	COG0668	transmembrane transport
HYI42_05945	COG0583	DNA-binding transcription factor activity
HYI42_05970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HYI42_05975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HYI42_06005	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HYI42_06040	COG2205	protein histidine kinase activity
HYI42_06045	COG0745	RESPONSE REGULATOR receiver
HYI42_06065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HYI42_06075	COG0384	phenazine biosynthesis protein PhzF
HYI42_06095	COG1309	transcriptional regulator
HYI42_06100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYI42_06135	COG1473	amidohydrolase
HYI42_06145	COG0583	DNA-binding transcription factor activity
HYI42_06160	COG0583	DNA-binding transcription factor activity
HYI42_06165	COG1053	succinate dehydrogenase
HYI42_06175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HYI42_06180	COG2814	Major facilitator Superfamily
HYI42_06185	COG1960	acyl-CoA dehydrogenase activity
HYI42_06190	COG0583	DNA-binding transcription factor activity
HYI42_06195	COG1063	alcohol dehydrogenase
HYI42_06225	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HYI42_06230	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HYI42_06235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYI42_06250	COG3667	copper resistance
HYI42_06255	COG2132	Multicopper oxidase
HYI42_06265	COG0561	phosphatase activity
HYI42_06270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HYI42_06280	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HYI42_06295	COG1214	PFAM Peptidase M22, glycoprotease
HYI42_06355	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HYI42_06360	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HYI42_06365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HYI42_06425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HYI42_06435	COG1846	Transcriptional regulator
HYI42_06440	COG1764	response to oxidative stress
HYI42_06480	COG0037	tRNA processing
HYI42_06490	COG0248	Ppx GppA phosphatase
HYI42_06520	COG0072	phenylalanine-tRNA ligase activity
HYI42_06560	COG0625	glutathione transferase activity
HYI42_06575	COG0318	PFAM AMP-dependent synthetase and ligase
HYI42_06580	COG3028	Belongs to the UPF0307 family
HYI42_06585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYI42_06605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HYI42_06610	COG0617	tRNA 3'-terminal CCA addition
HYI42_06615	COG1555	photosystem II stabilization
HYI42_06620	COG3956	TIGRFAM MazG family protein
HYI42_06630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYI42_06650	COG2205	protein histidine kinase activity
HYI42_06650	COG0784	Response regulator, receiver
HYI42_06650	COG5002	protein histidine kinase activity
HYI42_06655	COG1024	Enoyl-CoA hydratase
HYI42_06660	COG2084	Dehydrogenase
HYI42_06665	COG3622	Belongs to the hyi family
HYI42_06695	COG0697	spore germination
HYI42_06705	COG2814	Major facilitator Superfamily
HYI42_06725	COG2132	Multicopper oxidase
HYI42_06740	COG2205	protein histidine kinase activity
HYI42_06830	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HYI42_06850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HYI42_06860	COG0084	hydrolase, TatD family'
HYI42_06875	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HYI42_06905	COG0440	acetolactate synthase activity
HYI42_06910	COG0028	Belongs to the TPP enzyme family
HYI42_06935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYI42_06940	COG0577	efflux transmembrane transporter activity
HYI42_06940	COG1136	(ABC) transporter
HYI42_06945	COG1538	Outer membrane efflux protein
HYI42_06960	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HYI42_06965	COG1162	GTPase activity
HYI42_06975	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HYI42_07015	COG1426	Protein conserved in bacteria
HYI42_07050	COG0793	Belongs to the peptidase S41A family
HYI42_07065	COG2267	carboxylic ester hydrolase activity
HYI42_07075	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_07080	COG3265	gluconokinase activity
HYI42_07100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HYI42_07105	COG0280	phosphate acetyltransferase
HYI42_07105	COG0857	belongs to the CobB CobQ family
HYI42_07110	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HYI42_07110	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HYI42_07130	COG0740	serine-type endopeptidase activity
HYI42_07140	COG4774	siderophore transport
HYI42_07150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HYI42_07160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYI42_07160	COG2813	Specifically methylates the guanine in position
HYI42_07235	COG0589	response to stress
HYI42_07240	COG0659	secondary active sulfate transmembrane transporter activity
HYI42_07255	COG1061	Type III restriction enzyme res subunit
HYI42_07340	COG0788	formyltetrahydrofolate deformylase activity
HYI42_07365	COG4651	solute:proton antiporter activity
HYI42_07365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYI42_07385	COG0724	RNA recognition motif
HYI42_07390	COG0210	DNA helicase
HYI42_07415	COG1733	regulation of RNA biosynthetic process
HYI42_07425	COG2900	Belongs to the SlyX family
HYI42_07445	COG1280	lysine exporter protein (LysE YggA)
HYI42_07450	COG1560	Kdo2-lipid A biosynthetic process
HYI42_07460	COG1301	dicarboxylic acid transport
HYI42_07515	COG0473	3-isopropylmalate dehydrogenase activity
HYI42_07580	COG0625	glutathione transferase activity
HYI42_07585	COG2378	regulation of single-species biofilm formation
HYI42_07590	COG0546	phosphoglycolate phosphatase activity
HYI42_07605	COG1530	ribonuclease E activity
HYI42_07610	COG0318	PFAM AMP-dependent synthetase and ligase
HYI42_07625	COG0583	DNA-binding transcription factor activity
HYI42_07630	COG4221	oxidoreductase activity
HYI42_07635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYI42_07645	COG0534	Mate efflux family protein
HYI42_07660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HYI42_07695	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HYI42_07700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYI42_07715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYI42_07725	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HYI42_07725	COG0644	oxidoreductase
HYI42_07735	COG0425	Belongs to the sulfur carrier protein TusA family
HYI42_07740	COG4535	Mg2 and Co2 transporter CorC
HYI42_07750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HYI42_07770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HYI42_07775	COG0475	glutathione-regulated potassium exporter activity
HYI42_07775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYI42_07790	COG0484	heat shock protein binding
HYI42_07795	COG0789	Transcriptional regulator
HYI42_07800	COG0598	Magnesium transport protein CorA
HYI42_07820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYI42_07825	COG1074	ATP-dependent DNA helicase activity
HYI42_07830	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HYI42_07850	COG2226	methyltransferase
HYI42_07865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYI42_07870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HYI42_07890	COG1006	Multisubunit Na H antiporter MnhC subunit
HYI42_07895	COG0651	ATP synthesis coupled electron transport
HYI42_07905	COG2212	antiporter activity
HYI42_07925	COG0195	Participates in both transcription termination and antitermination
HYI42_07975	COG0237	dephospho-CoA kinase activity
HYI42_07985	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYI42_08000	COG0497	DNA recombination
HYI42_08010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HYI42_08040	COG2169	Transcriptional regulator
HYI42_08040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HYI42_08045	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HYI42_08105	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HYI42_08120	COG0326	Molecular chaperone. Has ATPase activity
HYI42_08135	COG2056	Na+-H+ antiporter family
HYI42_08235	COG0546	phosphoglycolate phosphatase activity
HYI42_08240	COG1716	ATPase activity
HYI42_08285	COG0181	hydroxymethylbilane synthase activity
HYI42_08295	COG3275	phosphorelay sensor kinase activity
HYI42_08315	COG1538	Outer membrane efflux protein
HYI42_08320	COG0697	spore germination
HYI42_08345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HYI42_08350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HYI42_08355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYI42_08360	COG0772	Belongs to the SEDS family
HYI42_08385	COG4974	Belongs to the 'phage' integrase family
HYI42_08390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HYI42_08400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HYI42_08410	COG2197	response regulator
HYI42_08425	COG0793	Belongs to the peptidase S41A family
HYI42_08430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HYI42_08435	COG0795	lipopolysaccharide-transporting ATPase activity
HYI42_08475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYI42_08475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HYI42_08485	COG0004	ammonium transporteR
HYI42_08490	COG0347	Belongs to the P(II) protein family
HYI42_08500	COG0606	chelatase, subunit chli
HYI42_08515	COG0659	secondary active sulfate transmembrane transporter activity
HYI42_08540	COG0789	Transcriptional regulator
HYI42_08560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYI42_08640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HYI42_08695	COG0697	spore germination
HYI42_08715	COG0789	Transcriptional regulator
HYI42_08800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HYI42_08830	COG0789	Transcriptional regulator
HYI42_08845	COG0640	Transcriptional regulator
HYI42_08855	COG0798	PFAM Bile acid sodium symporter
HYI42_08860	COG0431	NADPH-dependent FMN reductase
HYI42_08865	COG0492	ferredoxin-NADP+ reductase activity
HYI42_08870	COG2072	flavoprotein involved in K transport
HYI42_08900	COG0606	chelatase, subunit chli
HYI42_08905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYI42_08915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYI42_08930	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HYI42_08945	COG0318	PFAM AMP-dependent synthetase and ligase
HYI42_08955	COG0477	Major facilitator Superfamily
HYI42_08960	COG2860	membrane
HYI42_08965	COG3012	SEC-C Motif Domain Protein
HYI42_08970	COG1253	flavin adenine dinucleotide binding
HYI42_08980	COG2814	Major facilitator Superfamily
HYI42_08990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HYI42_09025	COG0655	NAD(P)H dehydrogenase (quinone) activity
HYI42_09035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HYI42_09105	COG0758	DNA mediated transformation
HYI42_09115	COG0697	spore germination
HYI42_09120	COG1309	transcriptional regulator
HYI42_09135	COG0386	Belongs to the glutathione peroxidase family
HYI42_09200	COG1121	(ABC) transporter
HYI42_09205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HYI42_09210	COG1280	lysine exporter protein (LysE YggA)
HYI42_09215	COG2837	iron assimilation
HYI42_09220	COG0281	malic enzyme
HYI42_09265	COG0519	Catalyzes the synthesis of GMP from XMP
HYI42_09265	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYI42_09270	COG4399	Belongs to the UPF0754 family
HYI42_09275	COG2259	Doxx family
HYI42_09280	COG0586	Pfam SNARE associated Golgi protein
HYI42_09295	COG1192	Involved in chromosome partitioning
HYI42_09305	COG0271	Belongs to the BolA IbaG family
HYI42_09325	COG2267	carboxylic ester hydrolase activity
HYI42_09345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HYI42_09345	COG4221	oxidoreductase activity
HYI42_09345	COG0300	oxidoreductase activity
HYI42_09345	COG3321	synthase
HYI42_09350	COG1960	acyl-CoA dehydrogenase activity
HYI42_09360	COG2197	response regulator
HYI42_09370	COG3916	Acyl-homoserine-lactone synthase
HYI42_09380	COG1024	Enoyl-CoA hydratase
HYI42_09385	COG1024	Enoyl-CoA hydratase
HYI42_09390	COG1960	acyl-CoA dehydrogenase activity
HYI42_09395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYI42_09415	COG1113	amino acid transport
HYI42_09420	COG1113	amino acid transport
HYI42_09425	COG0251	oxidation-reduction process
HYI42_09465	COG0564	pseudouridine synthase activity
HYI42_09480	COG3328	transposase activity
HYI42_09505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HYI42_09520	COG1802	Transcriptional regulator
HYI42_09530	COG1448	Aminotransferase
HYI42_09535	COG0277	FAD linked oxidase domain protein
HYI42_09545	COG2186	Transcriptional regulator
HYI42_09555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HYI42_09575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HYI42_09590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HYI42_09600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HYI42_09645	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HYI42_09675	COG0728	peptidoglycan biosynthetic process
HYI42_09680	COG3023	N-Acetylmuramoyl-L-alanine amidase
HYI42_09740	COG0546	phosphoglycolate phosphatase activity
HYI42_09745	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_09765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYI42_09770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYI42_09775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYI42_09780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYI42_09785	COG1116	anion transmembrane transporter activity
HYI42_09790	COG1309	transcriptional regulator
HYI42_09795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HYI42_09805	COG0196	riboflavin kinase activity
HYI42_09810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HYI42_09820	COG1047	Peptidyl-prolyl cis-trans
HYI42_09860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HYI42_09920	COG2951	lytic endotransglycosylase activity
HYI42_09925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HYI42_09940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HYI42_09950	COG0671	phosphoesterase, PA-phosphatase related
HYI42_09955	COG0861	Integral membrane protein TerC family
HYI42_09965	COG0754	glutathionylspermidine amidase activity
HYI42_09975	COG0402	S-adenosylhomocysteine deaminase activity
HYI42_09995	COG1230	cation diffusion facilitator family transporter
HYI42_10010	COG0706	membrane insertase activity
HYI42_10035	COG0592	DNA-directed DNA polymerase activity
HYI42_10045	COG0187	DNA topoisomerase II activity
HYI42_10055	COG0586	Pfam SNARE associated Golgi protein
HYI42_10060	COG0488	(ABC) transporter
HYI42_10105	COG0596	Alpha beta hydrolase
HYI42_10110	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HYI42_10115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HYI42_10160	COG0733	neurotransmitter:sodium symporter activity
HYI42_10170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HYI42_10195	COG0583	DNA-binding transcription factor activity
HYI42_10200	COG2233	PERMEase
HYI42_10215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYI42_10250	COG2814	Major facilitator Superfamily
HYI42_10255	COG0656	L-ascorbic acid biosynthetic process
HYI42_10260	COG0583	DNA-binding transcription factor activity
HYI42_10275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYI42_10280	COG1064	alcohol dehydrogenase
HYI42_10285	COG2818	Glycosylase
HYI42_10300	COG1194	a g-specific adenine glycosylase
HYI42_10320	COG2983	Belongs to the UPF0260 family
HYI42_10325	COG2133	pyrroloquinoline quinone binding
HYI42_10330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HYI42_10335	COG2116	formate transmembrane transporter activity
HYI42_10355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HYI42_10360	COG1335	isochorismatase
HYI42_10365	COG0385	Bile acid
HYI42_10370	COG0534	Mate efflux family protein
HYI42_10375	COG1683	Conserved Protein
HYI42_10405	COG1113	amino acid transport
HYI42_10415	COG0523	cobalamin synthesis protein
HYI42_10425	COG2188	Transcriptional regulator
HYI42_10455	COG0010	Belongs to the arginase family
HYI42_10470	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HYI42_10500	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HYI42_10510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HYI42_10515	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HYI42_10600	COG0534	Mate efflux family protein
HYI42_10605	COG0436	Aminotransferase
HYI42_10610	COG2733	membrane
HYI42_10625	COG2918	glutathione biosynthetic process
HYI42_10665	COG3150	esterase
HYI42_10675	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HYI42_10685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HYI42_10695	COG2233	PERMEase
HYI42_10700	COG2351	hydroxyisourate hydrolase activity
HYI42_10735	COG3706	GGDEF domain
HYI42_10750	COG1393	Belongs to the ArsC family
HYI42_10755	COG0708	Exodeoxyribonuclease III
HYI42_10775	COG0189	ligase activity
HYI42_10795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HYI42_10805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HYI42_10820	COG4942	peptidase
HYI42_10830	COG0508	dehydrogenase complex catalyzes the overall conversion of
HYI42_10840	COG2119	membrane
HYI42_10845	COG4774	siderophore transport
HYI42_10850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYI42_10850	COG0426	domain, Protein
HYI42_10875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HYI42_10895	COG1902	pentaerythritol trinitrate reductase activity
HYI42_10900	COG1519	Transferase
HYI42_10905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYI42_10910	COG0668	transmembrane transport
HYI42_10920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HYI42_10925	COG1335	isochorismatase
HYI42_10930	COG1522	sequence-specific DNA binding
HYI42_10955	COG2198	Histidine kinase
HYI42_10955	COG2205	protein histidine kinase activity
HYI42_10955	COG0784	Response regulator, receiver
HYI42_10960	COG3162	membrane
HYI42_10965	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HYI42_10975	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYI42_10990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HYI42_10995	COG1309	transcriptional regulator
HYI42_11015	COG0352	thiamine-phosphate diphosphorylase activity
HYI42_11015	COG0351	phosphomethylpyrimidine kinase
HYI42_11015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HYI42_11025	COG2814	Major facilitator Superfamily
HYI42_11040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HYI42_11050	COG1113	amino acid transport
HYI42_11060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HYI42_11065	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_11075	COG1335	isochorismatase
HYI42_11105	COG2814	Major facilitator Superfamily
HYI42_11110	COG0583	DNA-binding transcription factor activity
HYI42_11130	COG0667	Aldo Keto reductase
HYI42_11150	COG1733	regulation of RNA biosynthetic process
HYI42_11165	COG1733	regulation of RNA biosynthetic process
HYI42_11170	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYI42_11180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HYI42_11240	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HYI42_11280	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HYI42_11310	COG0427	acetyl-CoA hydrolase
HYI42_11325	COG0745	RESPONSE REGULATOR receiver
HYI42_11335	COG0659	secondary active sulfate transmembrane transporter activity
HYI42_11340	COG4221	oxidoreductase activity
HYI42_11345	COG2873	o-acetylhomoserine
HYI42_11350	COG0488	(ABC) transporter
HYI42_11415	COG0833	amino acid
HYI42_11460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HYI42_11465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HYI42_11480	COG2226	methyltransferase
HYI42_11530	COG0067	glutamate synthase
HYI42_11530	COG0069	glutamate synthase activity
HYI42_11530	COG0070	glutamate synthase
HYI42_11535	COG0493	'glutamate synthase
HYI42_11545	COG1704	LemA family
HYI42_11550	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HYI42_11565	COG3307	-O-antigen
HYI42_11585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HYI42_11595	COG0194	GDP metabolic process
HYI42_11645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HYI42_11665	COG5380	lipid catabolic process
HYI42_11670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HYI42_11695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HYI42_11700	COG0277	FAD linked oxidase domain protein
HYI42_11710	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HYI42_11715	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYI42_11730	COG1289	transmembrane transporter activity
HYI42_11740	COG0628	permease
HYI42_11745	COG1192	Involved in chromosome partitioning
HYI42_11775	COG0833	amino acid
HYI42_11780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HYI42_11785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYI42_11795	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_11835	COG0583	DNA-binding transcription factor activity
HYI42_11880	COG0517	IMP dehydrogenase activity
HYI42_11885	COG1983	PspC domain protein
HYI42_11895	COG1960	acyl-CoA dehydrogenase activity
HYI42_11910	COG0408	coproporphyrinogen oxidase activity
HYI42_11930	COG0513	Belongs to the DEAD box helicase family
HYI42_11940	COG1127	ABC transporter
HYI42_11945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HYI42_11955	COG2854	intermembrane phospholipid transfer
HYI42_11965	COG0598	Magnesium transport protein CorA
HYI42_11975	COG0494	nUDIX hydrolase
HYI42_11980	COG1040	competence protein
HYI42_11985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HYI42_12005	COG1946	Acyl-CoA thioesterase
HYI42_12010	COG1301	dicarboxylic acid transport
HYI42_12025	COG1959	2 iron, 2 sulfur cluster binding
HYI42_12030	COG1017	nitric oxide dioxygenase activity
HYI42_12030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYI42_12035	COG0433	COG0433 Predicted ATPase
HYI42_12040	COG0626	cystathionine gamma-synthase activity
HYI42_12195	COG1960	acyl-CoA dehydrogenase activity
HYI42_12200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HYI42_12230	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HYI42_12235	COG0339	signal peptide processing
HYI42_12240	COG0557	exoribonuclease II activity
HYI42_12285	COG0179	Fumarylacetoacetate (FAA) hydrolase
HYI42_12290	COG2169	Transcriptional regulator
HYI42_12300	COG1295	ribonuclease BN
HYI42_12335	COG1702	phosphate starvation-inducible protein PhoH
HYI42_12345	COG0739	heme binding
HYI42_12345	COG1196	nuclear chromosome segregation
HYI42_12345	COG0741	lytic transglycosylase activity
HYI42_12375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HYI42_12380	COG1183	phosphatidylcholine synthase activity
HYI42_12425	COG1960	acyl-CoA dehydrogenase activity
HYI42_12430	COG1309	transcriptional regulator
HYI42_12445	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HYI42_12450	COG1960	acyl-CoA dehydrogenase activity
HYI42_12470	COG2969	positive regulation of protein catabolic process
HYI42_12480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HYI42_12495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HYI42_12500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HYI42_12520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HYI42_12530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HYI42_12545	COG2199	diguanylate cyclase activity
HYI42_12605	COG1607	acyl-coa hydrolase
HYI42_12635	COG2350	Protein conserved in bacteria
HYI42_12645	COG0613	PHP domain protein
HYI42_12650	COG3781	membrane
HYI42_12660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HYI42_12675	COG1862	Preprotein translocase
HYI42_12705	COG2205	protein histidine kinase activity
HYI42_12710	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HYI42_12730	COG0726	polysaccharide deacetylase
HYI42_12735	COG0463	Glycosyl transferase, family 2
HYI42_12740	COG0438	transferase activity, transferring glycosyl groups
HYI42_12805	COG1960	acyl-CoA dehydrogenase activity
HYI42_12810	COG1960	acyl-CoA dehydrogenase activity
HYI42_12820	COG2205	protein histidine kinase activity
HYI42_12825	COG0745	RESPONSE REGULATOR receiver
HYI42_12830	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HYI42_12850	COG2096	Adenosyltransferase
HYI42_12900	COG0285	dihydrofolate synthase activity
HYI42_12920	COG0450	alkyl hydroperoxide reductase
HYI42_12935	COG0477	Major facilitator Superfamily
HYI42_12940	COG1272	protein, Hemolysin III
HYI42_12950	COG2153	protein acetylation
HYI42_12970	COG0183	Belongs to the thiolase family
HYI42_12975	COG2207	Transcriptional regulator
HYI42_12995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYI42_13015	COG0183	Belongs to the thiolase family
HYI42_13025	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HYI42_13025	COG2885	chlorophyll binding
HYI42_13035	COG1690	Belongs to the RtcB family
HYI42_13040	COG0833	amino acid
HYI42_13050	COG2233	PERMEase
HYI42_13080	COG2094	Belongs to the DNA glycosylase MPG family
HYI42_13085	COG4772	TonB-dependent receptor
HYI42_13090	COG1902	pentaerythritol trinitrate reductase activity
HYI42_13105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HYI42_13110	COG0354	folic acid binding
HYI42_13120	COG3189	MarR family transcriptional regulator
HYI42_13125	COG2824	Alkylphosphonate utilization operon protein PhnA
HYI42_13130	COG3422	double-strand break repair
HYI42_13170	COG0840	transmembrane signaling receptor activity
HYI42_13185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HYI42_13210	COG2832	Protein of unknown function (DUF454)
HYI42_13215	COG1376	ErfK ybiS ycfS ynhG family protein
HYI42_13255	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HYI42_13265	COG1289	transmembrane transporter activity
HYI42_13270	COG2814	Major facilitator Superfamily
HYI42_13290	COG1115	amino acid carrier protein
HYI42_13295	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYI42_13300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYI42_13305	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HYI42_13330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYI42_13340	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HYI42_13345	COG1077	Cell shape determining protein MreB Mrl
HYI42_13350	COG1792	Involved in formation and maintenance of cell shape
HYI42_13355	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HYI42_13360	COG0424	maF-like protein
HYI42_13365	COG1530	ribonuclease E activity
HYI42_13375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYI42_13385	COG0560	Phosphoserine phosphatase
HYI42_13395	COG2249	NAD(P)H dehydrogenase (quinone) activity
HYI42_13420	COG2207	Transcriptional regulator
HYI42_13840	COG1113	amino acid transport
HYI42_13845	COG2828	Protein conserved in bacteria
HYI42_13850	COG0142	geranyltranstransferase activity
HYI42_13870	COG1752	Esterase of the alpha-beta hydrolase superfamily
HYI42_13895	COG0745	RESPONSE REGULATOR receiver
HYI42_13900	COG0642	Histidine kinase
HYI42_13910	COG0004	ammonium transporteR
HYI42_13935	COG0525	valine-tRNA ligase activity
HYI42_13945	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_13955	COG0393	Putative heavy-metal-binding
HYI42_13960	COG0393	Putative heavy-metal-binding
HYI42_13965	COG1538	Outer membrane efflux protein
HYI42_13975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYI42_13980	COG0671	phosphoesterase, PA-phosphatase related
HYI42_14010	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HYI42_14025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HYI42_14025	COG1648	precorrin-2 dehydrogenase activity
HYI42_14030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HYI42_14035	COG1733	regulation of RNA biosynthetic process
HYI42_14045	COG0531	amino acid
HYI42_14060	COG0321	lipoyl(octanoyl) transferase activity
HYI42_14065	COG2921	Belongs to the UPF0250 family
HYI42_14100	COG2009	succinate dehydrogenase
HYI42_14105	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HYI42_14110	COG1053	succinate dehydrogenase
HYI42_14115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HYI42_14140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYI42_14170	COG2354	Protein conserved in bacteria
HYI42_14175	COG2321	neutral zinc metallopeptidase
HYI42_14260	COG0589	response to stress
HYI42_14280	COG0505	Belongs to the CarA family
HYI42_14305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HYI42_14310	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HYI42_14360	COG0477	Major facilitator Superfamily
HYI42_14365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HYI42_14380	COG1597	lipid kinase activity
HYI42_14385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HYI42_14415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYI42_14420	COG0584	glycerophosphoryl diester phosphodiesterase
HYI42_14440	COG0741	lytic transglycosylase activity
HYI42_14460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HYI42_14475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYI42_14505	COG0778	Nitroreductase
HYI42_14520	COG1929	Belongs to the glycerate kinase type-1 family
HYI42_14525	COG0243	molybdopterin cofactor binding
HYI42_14530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HYI42_14535	COG3339	Conserved Protein
HYI42_14545	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HYI42_14560	COG1113	amino acid transport
HYI42_14570	COG0019	diaminopimelate decarboxylase activity
HYI42_14580	COG2267	carboxylic ester hydrolase activity
HYI42_14585	COG1280	lysine exporter protein (LysE YggA)
HYI42_14590	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HYI42_14620	COG0463	Glycosyl transferase, family 2
HYI42_14640	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYI42_14670	COG4591	ABC-type transport system involved in lipoprotein release permease component
HYI42_14675	COG1136	(ABC) transporter
HYI42_14680	COG2333	competence protein COMEC
HYI42_14680	COG0658	competence protein
HYI42_14690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HYI42_14690	COG0616	signal peptide processing
HYI42_14695	COG0596	Alpha beta hydrolase
HYI42_14700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HYI42_14710	COG0628	permease
HYI42_14745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HYI42_14765	COG0823	Involved in the tonB-independent uptake of proteins
HYI42_14785	COG0824	Thioesterase
HYI42_14790	COG1473	amidohydrolase
HYI42_14810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HYI42_14810	COG0047	phosphoribosylformylglycinamidine synthase activity
HYI42_14815	COG2814	Major facilitator Superfamily
HYI42_14825	COG1024	Enoyl-CoA hydratase
HYI42_14830	COG1056	cytidyltransferase-related domain
HYI42_14830	COG1051	belongs to the nudix hydrolase family
HYI42_14840	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HYI42_14855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HYI42_14870	COG4625	pathogenesis
HYI42_14875	COG0583	DNA-binding transcription factor activity
HYI42_14880	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HYI42_14885	COG4208	sulfate ABC transporter
HYI42_14890	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HYI42_14900	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HYI42_14905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HYI42_14910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HYI42_14930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYI42_14945	COG0681	Belongs to the peptidase S26 family
HYI42_14960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HYI42_14970	COG1381	Involved in DNA repair and RecF pathway recombination
HYI42_14975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HYI42_14985	COG4221	oxidoreductase activity
HYI42_15015	COG0436	Aminotransferase
HYI42_15035	COG0556	nucleotide-excision repair
HYI42_15090	COG2070	2-Nitropropane dioxygenase
HYI42_15120	COG1215	transferase activity, transferring glycosyl groups
HYI42_15135	COG0415	Belongs to the DNA photolyase family
HYI42_15145	COG1252	NADH dehydrogenase
HYI42_15150	COG1686	Belongs to the peptidase S11 family
HYI42_15165	COG1187	pseudouridine synthase activity
HYI42_15185	COG0477	Major facilitator Superfamily
HYI42_15190	COG0583	DNA-binding transcription factor activity
HYI42_15205	COG0612	Peptidase, M16
HYI42_15235	COG1203	CRISPR-associated helicase, Cas3
HYI42_15260	COG0352	thiamine-phosphate diphosphorylase activity
HYI42_15295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HYI42_15310	COG1309	transcriptional regulator
HYI42_15320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HYI42_15325	COG0076	glutamate decarboxylase activity
HYI42_15335	COG1522	sequence-specific DNA binding
HYI42_15340	COG3961	Belongs to the TPP enzyme family
HYI42_15345	COG1113	amino acid transport
HYI42_15350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HYI42_15355	COG0573	inorganic phosphate transmembrane transporter activity
HYI42_15365	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HYI42_15370	COG0616	signal peptide processing
HYI42_15405	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HYI42_15410	COG1686	Belongs to the peptidase S11 family
HYI42_15435	COG0583	DNA-binding transcription factor activity
HYI42_15440	COG1067	ATP-dependent peptidase activity
HYI42_15465	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HYI42_15485	COG1966	Carbon starvation protein
HYI42_15490	COG2879	small protein
HYI42_15500	COG0583	DNA-binding transcription factor activity
HYI42_15505	COG0006	proline dipeptidase activity
HYI42_15510	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYI42_15515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HYI42_15525	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_15530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYI42_15535	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HYI42_15535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HYI42_15595	COG1741	Belongs to the pirin family
HYI42_15605	COG2964	Protein conserved in bacteria
HYI42_15620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HYI42_15625	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HYI42_15630	COG4605	iron ion homeostasis
HYI42_15635	COG4604	ABC transporter, ATP-binding protein
HYI42_15640	COG4607	ABC-type enterochelin transport system periplasmic component
HYI42_15645	COG4774	siderophore transport
HYI42_15660	COG1021	2,3-dihydroxybenzoate-AMP ligase
HYI42_15665	COG1535	isochorismatase
HYI42_15665	COG3433	isochorismatase activity
HYI42_15675	COG1132	(ABC) transporter
HYI42_15710	COG3739	integral membrane protein
HYI42_15740	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HYI42_15770	COG0308	aminopeptidase N
HYI42_15775	COG0512	Glutamine amidotransferase of anthranilate synthase
HYI42_15785	COG3104	oligopeptide transport
HYI42_15790	COG0174	glutamine synthetase
HYI42_15800	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HYI42_15835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HYI42_15840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HYI42_15845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HYI42_15870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HYI42_15875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HYI42_15880	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HYI42_15895	COG1960	acyl-CoA dehydrogenase activity
HYI42_15900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HYI42_15905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HYI42_15915	COG2223	nitrite transmembrane transporter activity
HYI42_15925	COG0024	Methionine aminopeptidase
HYI42_15930	COG0052	Belongs to the universal ribosomal protein uS2 family
HYI42_15945	COG2207	Transcriptional regulator
HYI42_15970	COG2951	lytic endotransglycosylase activity
HYI42_15975	COG0772	Belongs to the SEDS family
HYI42_15990	COG0842	Transport permease protein
HYI42_15995	COG1131	(ABC) transporter
HYI42_16000	COG0582	viral genome integration into host DNA
HYI42_16040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HYI42_16100	COG0305	Participates in initiation and elongation during chromosome replication
HYI42_16200	COG5410	chromosome segregation
HYI42_16320	COG0739	heme binding
HYI42_16415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYI42_16430	COG4215	(ABC) transporter
HYI42_16435	COG4160	amino acid transport
HYI42_16450	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HYI42_16460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HYI42_16475	COG1720	tRNA m6t6A37 methyltransferase activity
HYI42_16495	COG0745	RESPONSE REGULATOR receiver
HYI42_16500	COG0642	Histidine kinase
HYI42_16510	COG0494	nUDIX hydrolase
HYI42_16525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HYI42_16530	COG3139	Protein of unknown function (DUF1315)
HYI42_16535	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HYI42_16540	COG1301	dicarboxylic acid transport
HYI42_16545	COG1960	acyl-CoA dehydrogenase activity
HYI42_16550	COG2819	hydrolase of the alpha beta superfamily
HYI42_16560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HYI42_16570	COG2195	Cleaves the N-terminal amino acid of tripeptides
HYI42_16575	COG1234	tRNA 3'-trailer cleavage
HYI42_16600	COG2363	Small membrane protein
HYI42_16620	COG0513	Belongs to the DEAD box helicase family
HYI42_16630	COG0778	Nitroreductase
HYI42_16660	COG1286	toxin biosynthetic process
HYI42_16685	COG4783	chaperone-mediated protein folding
HYI42_16690	COG1610	YqeY-like protein
HYI42_16790	COG3111	PFAM Bacterial OB fold (BOF) protein
HYI42_16815	COG3243	poly(R)-hydroxyalkanoic acid synthase
HYI42_16820	COG0786	glutamate:sodium symporter activity
HYI42_16830	COG0583	DNA-binding transcription factor activity
HYI42_16840	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_16855	COG2186	Transcriptional regulator
HYI42_16915	COG0477	Major facilitator Superfamily
HYI42_16940	COG2995	paraquat-inducible protein a
HYI42_16945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HYI42_16945	COG3008	intermembrane lipid transfer
HYI42_16955	COG2351	hydroxyisourate hydrolase activity
HYI42_17005	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HYI42_17010	COG0642	Histidine kinase
HYI42_17015	COG0745	RESPONSE REGULATOR receiver
HYI42_17035	COG1794	racemase activity, acting on amino acids and derivatives
HYI42_17065	COG1301	dicarboxylic acid transport
HYI42_17075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HYI42_17080	COG2011	ABC-type metal ion transport system permease component
HYI42_17085	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HYI42_17090	COG1464	Belongs to the NlpA lipoprotein family
HYI42_17095	COG0151	Belongs to the GarS family
HYI42_17100	COG0138	bifunctional purine biosynthesis protein purh
HYI42_17105	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HYI42_17135	COG2308	Evidence 4 Homologs of previously reported genes of
HYI42_17145	COG1305	Transglutaminase-like
HYI42_17155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HYI42_17160	COG0305	Participates in initiation and elongation during chromosome replication
HYI42_17185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HYI42_17195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HYI42_17200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HYI42_17230	COG1215	transferase activity, transferring glycosyl groups
HYI42_17235	COG3658	cytochrome
HYI42_17245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HYI42_17260	COG0583	DNA-binding transcription factor activity
HYI42_17280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HYI42_17285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYI42_17300	COG1960	acyl-CoA dehydrogenase activity
HYI42_17310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYI42_17335	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HYI42_17340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HYI42_17355	COG0745	RESPONSE REGULATOR receiver
HYI42_17380	COG0729	surface antigen
HYI42_17405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HYI42_17410	COG2814	Major facilitator Superfamily
HYI42_17425	COG0583	DNA-binding transcription factor activity
HYI42_17460	COG0802	atpase or kinase
HYI42_17465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HYI42_17480	COG0697	spore germination
HYI42_17505	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HYI42_17510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HYI42_17510	COG0519	Catalyzes the synthesis of GMP from XMP
HYI42_17515	COG4302	ethanolamine ammonia-lyase activity
HYI42_17520	COG4303	Ethanolamine ammonia lyase large subunit
HYI42_17525	COG0531	amino acid
HYI42_17545	COG1454	alcohol dehydrogenase
HYI42_17550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HYI42_17575	COG0308	aminopeptidase N
HYI42_17615	COG1605	Chorismate mutase
HYI42_17640	COG1309	transcriptional regulator
HYI42_17650	COG0668	transmembrane transport
HYI42_17700	COG0488	(ABC) transporter
HYI42_17705	COG0589	response to stress
HYI42_17770	COG3135	benzoate transporter
HYI42_17775	COG1522	sequence-specific DNA binding
HYI42_17785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HYI42_17790	COG0583	DNA-binding transcription factor activity
HYI42_17800	COG0183	Belongs to the thiolase family
HYI42_17810	COG2030	dehydratase
HYI42_17830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HYI42_17840	COG0824	Thioesterase
HYI42_17845	COG1454	alcohol dehydrogenase
HYI42_17855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HYI42_17875	COG0069	glutamate synthase activity
HYI42_17910	COG0511	ligase activity, forming carbon-carbon bonds
HYI42_17930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HYI42_17930	COG1116	anion transmembrane transporter activity
HYI42_17935	COG0745	RESPONSE REGULATOR receiver
HYI42_17945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYI42_17945	COG2146	nitrite reductase [NAD(P)H] activity
HYI42_17950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HYI42_17955	COG0243	molybdopterin cofactor binding
HYI42_17965	COG0243	molybdopterin cofactor binding
HYI42_17970	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HYI42_17985	COG0315	cyclic pyranopterin monophosphate synthase activity
HYI42_17985	COG0521	Mo-molybdopterin cofactor biosynthetic process
HYI42_17990	COG0303	'Molybdopterin
HYI42_18005	COG0697	spore germination
HYI42_18025	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HYI42_18030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HYI42_18085	COG2204	response regulator
HYI42_18090	COG3852	Histidine kinase
HYI42_18115	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HYI42_18120	COG0575	Belongs to the CDS family
HYI42_18155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HYI42_18170	COG2137	regulation of response to DNA damage stimulus
HYI42_18180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HYI42_18185	COG1011	Hydrolase
HYI42_18220	COG1113	amino acid transport
HYI42_18235	COG0659	secondary active sulfate transmembrane transporter activity
HYI42_18240	COG2135	peptidase activity
HYI42_18255	COG3300	MHYT domain
HYI42_18255	COG5001	Diguanylate cyclase
HYI42_18275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HYI42_18275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HYI42_18275	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HYI42_18280	COG1105	Belongs to the carbohydrate kinase PfkB family
HYI42_18285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HYI42_18285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HYI42_18315	COG0024	Methionine aminopeptidase
HYI42_18330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HYI42_18335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HYI42_18340	COG0517	IMP dehydrogenase activity
HYI42_18340	COG0516	GMP reductase activity
HYI42_18365	COG0552	protein localization to endoplasmic reticulum
HYI42_18375	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HYI42_18385	COG4890	Cyd operon protein YbgT
HYI42_18390	COG1294	oxidase, subunit
HYI42_18405	COG1585	Membrane protein implicated in regulation of membrane protease activity
HYI42_18415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HYI42_18435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HYI42_18440	COG0569	domain protein
HYI42_18445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HYI42_18475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HYI42_18480	COG0542	response to heat
HYI42_18505	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYI42_18505	COG1902	pentaerythritol trinitrate reductase activity
HYI42_18550	COG2323	membrane
HYI42_18555	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HYI42_18565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYI42_18570	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HYI42_18575	COG0183	Belongs to the thiolase family
HYI42_18580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HYI42_18585	COG0596	Alpha beta hydrolase
HYI42_18590	COG2271	Major facilitator Superfamily
HYI42_18595	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HYI42_18600	COG3485	protocatechuate 3,4-dioxygenase
HYI42_18605	COG3485	protocatechuate 3,4-dioxygenase
HYI42_18610	COG0710	3-dehydroquinate dehydratase activity
HYI42_18615	COG3420	alginic acid biosynthetic process
HYI42_18620	COG3659	wide pore channel activity
HYI42_18625	COG4993	Dehydrogenase
HYI42_18635	COG2391	methyltransferase activity
HYI42_18650	COG1414	Transcriptional regulator
HYI42_18655	COG0583	DNA-binding transcription factor activity
HYI42_18660	COG1960	acyl-CoA dehydrogenase activity
HYI42_18685	COG2814	Major facilitator Superfamily
HYI42_18695	COG0154	amidase activity
HYI42_18715	COG4638	Rieske (2fe-2S)
HYI42_18725	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_18735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HYI42_18745	COG3733	amine oxidase
HYI42_18755	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_18765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HYI42_18770	COG0183	Belongs to the thiolase family
HYI42_18775	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HYI42_18780	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HYI42_18790	COG4829	muconolactone delta-isomerase
HYI42_18795	COG4948	Mandelate Racemase Muconate Lactonizing
HYI42_18800	COG0583	DNA-binding transcription factor activity
HYI42_18810	COG2186	Transcriptional regulator
HYI42_18830	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_18845	COG0446	pyridine nucleotide-disulphide oxidoreductase
HYI42_18845	COG1902	pentaerythritol trinitrate reductase activity
HYI42_18885	COG1309	transcriptional regulator
HYI42_18895	COG4221	oxidoreductase activity
HYI42_18900	COG4689	acetoacetate decarboxylase
HYI42_18910	COG1902	pentaerythritol trinitrate reductase activity
HYI42_18930	COG1335	isochorismatase
HYI42_18935	COG0583	DNA-binding transcription factor activity
HYI42_18945	COG0475	glutathione-regulated potassium exporter activity
HYI42_18945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HYI42_18955	COG1473	amidohydrolase
HYI42_19015	COG2188	Transcriptional regulator
HYI42_19030	COG0583	DNA-binding transcription factor activity
HYI42_19045	COG1566	PFAM secretion protein HlyD family protein
HYI42_19060	COG1012	belongs to the aldehyde dehydrogenase family
HYI42_19065	COG0129	dihydroxy-acid dehydratase activity
HYI42_19075	COG0583	DNA-binding transcription factor activity
HYI42_19080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HYI42_19090	COG2084	Dehydrogenase
HYI42_19105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HYI42_19165	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HYI42_19215	COG1073	alpha beta
HYI42_19225	COG1028	Short-chain dehydrogenase reductase Sdr
HYI42_19240	COG2207	Transcriptional regulator
HYI42_19250	COG2205	protein histidine kinase activity
HYI42_19255	COG0745	RESPONSE REGULATOR receiver
HYI42_19260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HYI42_19265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HYI42_19270	COG1538	Outer membrane efflux protein
HYI42_19280	COG2072	flavoprotein involved in K transport
HYI42_19290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity