locus-tag	class	description
AYP_000002	COG0592	DNA-directed DNA polymerase activity
AYP_000004	COG0187	DNA topoisomerase II activity
AYP_000006	COG0586	Pfam SNARE associated Golgi protein
AYP_000007	COG0488	(ABC) transporter
AYP_000012	COG0596	Alpha beta hydrolase
AYP_000013	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AYP_000014	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AYP_000023	COG1047	Peptidyl-prolyl cis-trans
AYP_000025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYP_000026	COG0196	riboflavin kinase activity
AYP_000028	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AYP_000029	COG1309	transcriptional regulator
AYP_000030	COG1116	anion transmembrane transporter activity
AYP_000031	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYP_000032	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYP_000033	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYP_000034	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYP_000038	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_000039	COG0546	phosphoglycolate phosphatase activity
AYP_000052	COG3023	N-Acetylmuramoyl-L-alanine amidase
AYP_000053	COG0728	peptidoglycan biosynthetic process
AYP_000058	COG1596	polysaccharide export
AYP_000059	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AYP_000060	COG1086	Polysaccharide biosynthesis protein
AYP_000061	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AYP_000062	COG1083	cytidylyl-transferase
AYP_000065	COG2089	acid synthase
AYP_000071	COG1216	Glycosyl transferase, family 2
AYP_000072	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AYP_000073	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AYP_000076	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYP_000077	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYP_000080	COG2186	Transcriptional regulator
AYP_000082	COG0277	FAD linked oxidase domain protein
AYP_000083	COG1448	Aminotransferase
AYP_000084	COG1802	Transcriptional regulator
AYP_000087	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AYP_000097	COG0564	pseudouridine synthase activity
AYP_000102	COG1522	sequence-specific DNA binding
AYP_000105	COG0251	oxidation-reduction process
AYP_000106	COG1113	amino acid transport
AYP_000107	COG1113	amino acid transport
AYP_000111	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYP_000112	COG1960	acyl-CoA dehydrogenase activity
AYP_000113	COG1024	Enoyl-CoA hydratase
AYP_000114	COG1024	Enoyl-CoA hydratase
AYP_000115	COG0477	Major facilitator Superfamily
AYP_000116	COG3916	Acyl-homoserine-lactone synthase
AYP_000118	COG2197	response regulator
AYP_000120	COG1960	acyl-CoA dehydrogenase activity
AYP_000121	COG3321	synthase
AYP_000121	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AYP_000121	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYP_000121	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AYP_000123	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_000126	COG2267	carboxylic ester hydrolase activity
AYP_000130	COG0271	Belongs to the BolA IbaG family
AYP_000132	COG1192	Involved in chromosome partitioning
AYP_000135	COG0586	Pfam SNARE associated Golgi protein
AYP_000136	COG2259	Doxx family
AYP_000137	COG4399	Belongs to the UPF0754 family
AYP_000138	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYP_000138	COG0519	Catalyzes the synthesis of GMP from XMP
AYP_000147	COG0281	malic enzyme
AYP_000149	COG2837	iron assimilation
AYP_000150	COG1280	lysine exporter protein (LysE YggA)
AYP_000151	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYP_000152	COG1121	(ABC) transporter
AYP_000165	COG0386	Belongs to the glutathione peroxidase family
AYP_000168	COG1309	transcriptional regulator
AYP_000169	COG0697	spore germination
AYP_000171	COG0758	DNA mediated transformation
AYP_000178	COG1309	transcriptional regulator
AYP_000185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AYP_000187	COG0655	NAD(P)H dehydrogenase (quinone) activity
AYP_000194	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYP_000199	COG1253	flavin adenine dinucleotide binding
AYP_000201	COG2860	membrane
AYP_000202	COG0477	Major facilitator Superfamily
AYP_000204	COG0318	PFAM AMP-dependent synthetase and ligase
AYP_000207	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AYP_000211	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYP_000213	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_000214	COG0606	chelatase, subunit chli
AYP_000221	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYP_000229	COG0589	response to stress
AYP_000230	COG0659	secondary active sulfate transmembrane transporter activity
AYP_000239	COG0606	chelatase, subunit chli
AYP_000241	COG0347	Belongs to the P(II) protein family
AYP_000242	COG0004	ammonium transporteR
AYP_000244	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYP_000244	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AYP_000252	COG0795	lipopolysaccharide-transporting ATPase activity
AYP_000253	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AYP_000254	COG0793	Belongs to the peptidase S41A family
AYP_000257	COG2197	response regulator
AYP_000259	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AYP_000261	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYP_000262	COG4974	Belongs to the 'phage' integrase family
AYP_000267	COG0772	Belongs to the SEDS family
AYP_000268	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYP_000269	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AYP_000270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYP_000277	COG1538	Outer membrane efflux protein
AYP_000281	COG3275	phosphorelay sensor kinase activity
AYP_000283	COG0181	hydroxymethylbilane synthase activity
AYP_000292	COG1716	ATPase activity
AYP_000293	COG0546	phosphoglycolate phosphatase activity
AYP_000314	COG0596	Alpha beta hydrolase
AYP_000315	COG2056	Na+-H+ antiporter family
AYP_000318	COG0326	Molecular chaperone. Has ATPase activity
AYP_000321	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AYP_000334	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AYP_000335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYP_000335	COG2169	Transcriptional regulator
AYP_000341	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AYP_000343	COG0497	DNA recombination
AYP_000346	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYP_000348	COG0237	dephospho-CoA kinase activity
AYP_000358	COG0195	Participates in both transcription termination and antitermination
AYP_000362	COG2212	antiporter activity
AYP_000364	COG0651	ATP synthesis coupled electron transport
AYP_000365	COG1006	Multisubunit Na H antiporter MnhC subunit
AYP_000366	COG2111	Na H antiporter
AYP_000366	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYP_000369	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AYP_000370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_000373	COG2226	methyltransferase
AYP_000377	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AYP_000378	COG1074	ATP-dependent DNA helicase activity
AYP_000379	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYP_000384	COG0598	Magnesium transport protein CorA
AYP_000385	COG0789	Transcriptional regulator
AYP_000386	COG0484	heat shock protein binding
AYP_000388	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AYP_000389	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYP_000389	COG0475	glutathione-regulated potassium exporter activity
AYP_000390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AYP_000394	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYP_000396	COG4535	Mg2 and Co2 transporter CorC
AYP_000397	COG0425	Belongs to the sulfur carrier protein TusA family
AYP_000398	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AYP_000398	COG0644	oxidoreductase
AYP_000400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYP_000403	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYP_000404	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AYP_000411	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AYP_000414	COG0534	Mate efflux family protein
AYP_000416	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AYP_000417	COG4221	oxidoreductase activity
AYP_000418	COG0583	DNA-binding transcription factor activity
AYP_000422	COG1530	ribonuclease E activity
AYP_000425	COG0546	phosphoglycolate phosphatase activity
AYP_000426	COG2378	regulation of single-species biofilm formation
AYP_000427	COG0625	glutathione transferase activity
AYP_000429	COG0583	DNA-binding transcription factor activity
AYP_000442	COG0473	3-isopropylmalate dehydrogenase activity
AYP_000453	COG1301	dicarboxylic acid transport
AYP_000455	COG1560	Kdo2-lipid A biosynthetic process
AYP_000456	COG1280	lysine exporter protein (LysE YggA)
AYP_000460	COG1733	regulation of RNA biosynthetic process
AYP_000465	COG0210	DNA helicase
AYP_000466	COG0724	RNA recognition motif
AYP_000470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYP_000470	COG4651	solute:proton antiporter activity
AYP_000471	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AYP_000472	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AYP_000475	COG0788	formyltetrahydrofolate deformylase activity
AYP_000495	COG2813	Specifically methylates the guanine in position
AYP_000495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYP_000497	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYP_000499	COG4774	siderophore transport
AYP_000501	COG0740	serine-type endopeptidase activity
AYP_000505	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AYP_000505	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AYP_000506	COG0280	phosphate acetyltransferase
AYP_000506	COG0857	belongs to the CobB CobQ family
AYP_000507	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYP_000509	COG0800	Aldolase
AYP_000511	COG3265	gluconokinase activity
AYP_000512	COG1012	belongs to the aldehyde dehydrogenase family
AYP_000514	COG2267	carboxylic ester hydrolase activity
AYP_000517	COG0793	Belongs to the peptidase S41A family
AYP_000524	COG1426	Protein conserved in bacteria
AYP_000532	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYP_000533	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYP_000535	COG0318	PFAM AMP-dependent synthetase and ligase
AYP_000538	COG2986	histidine ammonia-lyase
AYP_000546	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_000547	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYP_000551	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AYP_000553	COG1162	GTPase activity
AYP_000554	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AYP_000557	COG1538	Outer membrane efflux protein
AYP_000558	COG1136	(ABC) transporter
AYP_000558	COG0577	efflux transmembrane transporter activity
AYP_000559	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_000564	COG0028	Belongs to the TPP enzyme family
AYP_000565	COG0440	acetolactate synthase activity
AYP_000571	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AYP_000574	COG0084	hydrolase, TatD family'
AYP_000577	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AYP_000579	COG0583	DNA-binding transcription factor activity
AYP_000581	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYP_000582	COG2814	Major facilitator Superfamily
AYP_000584	COG0697	spore germination
AYP_000585	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AYP_000586	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AYP_000587	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AYP_000590	COG3622	Belongs to the hyi family
AYP_000591	COG2084	Dehydrogenase
AYP_000595	COG1024	Enoyl-CoA hydratase
AYP_000596	COG2205	protein histidine kinase activity
AYP_000596	COG5002	protein histidine kinase activity
AYP_000596	COG0784	Response regulator, receiver
AYP_000600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYP_000602	COG3956	TIGRFAM MazG family protein
AYP_000603	COG1555	photosystem II stabilization
AYP_000604	COG0617	tRNA 3'-terminal CCA addition
AYP_000605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AYP_000609	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYP_000610	COG3028	Belongs to the UPF0307 family
AYP_000611	COG0318	PFAM AMP-dependent synthetase and ligase
AYP_000614	COG0625	glutathione transferase activity
AYP_000615	COG1238	metal cluster binding
AYP_000618	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AYP_000623	COG0072	phenylalanine-tRNA ligase activity
AYP_000628	COG0248	Ppx GppA phosphatase
AYP_000630	COG0037	tRNA processing
AYP_000638	COG1764	response to oxidative stress
AYP_000639	COG1846	Transcriptional regulator
AYP_000641	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYP_000653	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYP_000654	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AYP_000655	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AYP_000657	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AYP_000668	COG1214	PFAM Peptidase M22, glycoprotease
AYP_000673	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AYP_000674	COG0561	phosphatase activity
AYP_000676	COG2132	Multicopper oxidase
AYP_000677	COG3667	copper resistance
AYP_000680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYP_000681	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AYP_000682	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AYP_000688	COG1063	alcohol dehydrogenase
AYP_000689	COG0583	DNA-binding transcription factor activity
AYP_000690	COG1960	acyl-CoA dehydrogenase activity
AYP_000691	COG2814	Major facilitator Superfamily
AYP_000692	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AYP_000694	COG1053	succinate dehydrogenase
AYP_000695	COG0583	DNA-binding transcription factor activity
AYP_000698	COG0583	DNA-binding transcription factor activity
AYP_000700	COG1473	amidohydrolase
AYP_000704	COG0583	DNA-binding transcription factor activity
AYP_000706	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AYP_000707	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_000711	COG0384	phenazine biosynthesis protein PhzF
AYP_000715	COG4993	Dehydrogenase
AYP_000727	COG2205	protein histidine kinase activity
AYP_000729	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYP_000732	COG0745	RESPONSE REGULATOR receiver
AYP_000733	COG2205	protein histidine kinase activity
AYP_000740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AYP_000746	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYP_000747	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AYP_000751	COG0583	DNA-binding transcription factor activity
AYP_000755	COG0668	transmembrane transport
AYP_000757	COG2081	HI0933 family
AYP_000758	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AYP_000764	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYP_000764	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYP_000766	COG0489	protein tyrosine kinase activity
AYP_000776	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AYP_000778	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AYP_000781	COG0730	response to heat
AYP_000783	COG1196	nuclear chromosome segregation
AYP_000787	COG2223	nitrite transmembrane transporter activity
AYP_000788	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AYP_000789	COG1877	trehalose-phosphatase activity
AYP_000790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYP_000790	COG0596	Alpha beta hydrolase
AYP_000790	COG2226	methyltransferase
AYP_000793	COG4106	trans-aconitate 2-methyltransferase activity
AYP_000796	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AYP_000797	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AYP_000798	COG0009	L-threonylcarbamoyladenylate synthase
AYP_000799	COG3101	peptidyl-lysine hydroxylation
AYP_000800	COG1399	metal-binding, possibly nucleic acid-binding protein
AYP_000805	COG1652	LysM domain
AYP_000806	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYP_000806	COG0352	thiamine-phosphate diphosphorylase activity
AYP_000806	COG0351	phosphomethylpyrimidine kinase
AYP_000808	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYP_000814	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYP_000820	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AYP_000823	COG0358	DNA primase activity
AYP_000825	COG0564	pseudouridine synthase activity
AYP_000830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYP_000833	COG0583	DNA-binding transcription factor activity
AYP_000834	COG0473	3-isopropylmalate dehydrogenase activity
AYP_000838	COG1012	belongs to the aldehyde dehydrogenase family
AYP_000842	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AYP_000842	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AYP_000854	COG0456	acetyltransferase
AYP_000856	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AYP_000857	COG0492	ferredoxin-NADP+ reductase activity
AYP_000858	COG1674	ftsk spoiiie
AYP_000858	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AYP_000859	COG1280	lysine exporter protein (LysE YggA)
AYP_000864	COG2894	cell division
AYP_000867	COG0204	Acyl-transferase
AYP_000868	COG2885	chlorophyll binding
AYP_000869	COG0210	DNA helicase
AYP_000871	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYP_000874	COG0121	glutamine amidotransferase
AYP_000878	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AYP_000879	COG0735	belongs to the Fur family
AYP_000884	COG0420	3'-5' exonuclease activity
AYP_000888	COG1090	epimerase
AYP_000891	COG2050	protein possibly involved in aromatic compounds catabolism
AYP_000893	COG2814	Major facilitator Superfamily
AYP_000894	COG0405	Gamma-glutamyltransferase
AYP_000900	COG0477	Major facilitator Superfamily
AYP_000901	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYP_000907	COG0531	amino acid
AYP_000908	COG2040	homocysteine
AYP_000913	COG1309	transcriptional regulator
AYP_000914	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_000915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_000917	COG1607	acyl-coa hydrolase
AYP_000919	COG0523	cobalamin synthesis protein
AYP_000921	COG4681	YaeQ
AYP_000923	COG0726	polysaccharide deacetylase
AYP_000923	COG1649	PFAM Uncharacterised BCR, COG1649
AYP_000924	COG1215	transferase activity, transferring glycosyl groups
AYP_000926	COG1024	Enoyl-CoA hydratase
AYP_000929	COG1414	Transcriptional regulator
AYP_000933	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_000935	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_000936	COG2271	Major facilitator Superfamily
AYP_000938	COG2267	carboxylic ester hydrolase activity
AYP_000939	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_000942	COG0028	Belongs to the TPP enzyme family
AYP_000944	COG0477	Major facilitator Superfamily
AYP_000946	COG0242	peptide deformylase activity
AYP_000947	COG2066	Belongs to the glutaminase family
AYP_000948	COG2207	Transcriptional regulator
AYP_000949	COG2223	nitrite transmembrane transporter activity
AYP_000952	COG0583	DNA-binding transcription factor activity
AYP_000953	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_000954	COG2271	Major facilitator Superfamily
AYP_000955	COG3959	Transketolase, thiamine diphosphate binding domain
AYP_000956	COG3958	Transketolase
AYP_000959	COG0306	phosphate transporter
AYP_000964	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AYP_000973	COG4181	ATPase activity
AYP_000974	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AYP_000979	COG0583	DNA-binding transcription factor activity
AYP_000981	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_000982	COG1773	rubredoxin
AYP_000992	COG2851	Citrate transporter
AYP_000993	COG1253	flavin adenine dinucleotide binding
AYP_001002	COG0804	urea catabolic process
AYP_001003	COG0804	urea catabolic process
AYP_001005	COG0830	nickel cation binding
AYP_001008	COG0742	ribosomal rna small subunit methyltransferase
AYP_001009	COG0768	penicillin binding
AYP_001013	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AYP_001014	COG2878	Part of a membrane complex involved in electron transport
AYP_001015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYP_001017	COG3384	dioxygenase
AYP_001024	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AYP_001088	COG0739	heme binding
AYP_001097	COG2194	sulfuric ester hydrolase activity
AYP_001103	COG0006	proline dipeptidase activity
AYP_001104	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_001105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_001111	COG1279	arginine transmembrane transporter activity
AYP_001112	COG0583	DNA-binding transcription factor activity
AYP_001120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYP_001121	COG0741	lytic transglycosylase activity
AYP_001121	COG0741	lytic transglycosylase activity
AYP_001121	COG1388	LysM domain
AYP_001121	COG1388	LysM domain
AYP_001123	COG4174	ABC transporter (Permease)
AYP_001124	COG4239	(ABC) transporter, permease
AYP_001125	COG4172	Belongs to the ABC transporter superfamily
AYP_001129	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYP_001131	COG3706	GGDEF domain
AYP_001131	COG2203	Gaf domain
AYP_001131	COG4251	negative regulation of phosphorylation
AYP_001131	COG5001	Diguanylate cyclase
AYP_001133	COG1902	pentaerythritol trinitrate reductase activity
AYP_001133	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_001136	COG4269	membrane
AYP_001141	COG3501	Rhs element vgr protein
AYP_001142	COG3316	Transposase and inactivated derivatives
AYP_001143	COG3316	Transposase and inactivated derivatives
AYP_001153	COG3316	Transposase and inactivated derivatives
AYP_001156	COG3316	Transposase and inactivated derivatives
AYP_001160	COG3316	Transposase and inactivated derivatives
AYP_001162	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AYP_001165	COG3316	Transposase and inactivated derivatives
AYP_001175	COG3316	Transposase and inactivated derivatives
AYP_001180	COG3316	Transposase and inactivated derivatives
AYP_001181	COG2072	flavoprotein involved in K transport
AYP_001182	COG0300	oxidoreductase activity
AYP_001184	COG1309	transcriptional regulator
AYP_001185	COG1741	Belongs to the pirin family
AYP_001188	COG2072	flavoprotein involved in K transport
AYP_001190	COG2252	PERMEase
AYP_001191	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AYP_001192	COG3038	cytochrome b561
AYP_001194	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYP_001198	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AYP_001200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AYP_001203	COG0667	Aldo Keto reductase
AYP_001207	COG1765	OsmC-like protein
AYP_001217	COG2885	chlorophyll binding
AYP_001219	COG0625	glutathione transferase activity
AYP_001220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AYP_001224	COG3634	alkyl hydroperoxide reductase activity
AYP_001226	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AYP_001228	COG0450	alkyl hydroperoxide reductase
AYP_001229	COG1643	Atp-dependent helicase
AYP_001232	COG2814	Major facilitator Superfamily
AYP_001233	COG3135	benzoate transporter
AYP_001234	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_001235	COG0543	2 iron, 2 sulfur cluster binding
AYP_001235	COG0633	Ferredoxin
AYP_001236	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYP_001237	COG4638	Rieske (2fe-2S)
AYP_001238	COG0583	DNA-binding transcription factor activity
AYP_001248	COG1570	exodeoxyribonuclease VII activity
AYP_001253	COG1280	lysine exporter protein (LysE YggA)
AYP_001254	COG1278	Cold shock
AYP_001261	COG2814	Major facilitator Superfamily
AYP_001262	COG1733	regulation of RNA biosynthetic process
AYP_001312	COG0517	IMP dehydrogenase activity
AYP_001312	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AYP_001313	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AYP_001315	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AYP_001316	COG1137	ATPase activity
AYP_001317	COG1538	Outer membrane efflux protein
AYP_001325	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AYP_001329	COG1522	sequence-specific DNA binding
AYP_001331	COG5006	permease, DMT superfamily
AYP_001333	COG1560	Kdo2-lipid A biosynthetic process
AYP_001335	COG2814	Major facilitator Superfamily
AYP_001339	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYP_001344	COG3501	Rhs element vgr protein
AYP_001345	COG3209	COG3209 Rhs family protein
AYP_001348	COG0583	DNA-binding transcription factor activity
AYP_001349	COG1914	H( )-stimulated, divalent metal cation uptake system
AYP_001353	COG4770	biotin carboxylase activity
AYP_001354	COG0038	chloride channel
AYP_001357	COG1309	transcriptional regulator
AYP_001359	COG1063	alcohol dehydrogenase
AYP_001362	COG0439	Biotin carboxylase
AYP_001363	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYP_001364	COG1733	regulation of RNA biosynthetic process
AYP_001368	COG0864	Transcriptional regulator
AYP_001370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYP_001371	COG1116	anion transmembrane transporter activity
AYP_001384	COG2885	chlorophyll binding
AYP_001384	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AYP_001392	COG0583	DNA-binding transcription factor activity
AYP_001394	COG0590	tRNA wobble adenosine to inosine editing
AYP_001395	COG2807	transmembrane transport
AYP_001398	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AYP_001402	COG0789	Transcriptional regulator
AYP_001404	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYP_001408	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYP_001410	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_001413	COG1012	belongs to the aldehyde dehydrogenase family
AYP_001414	COG0531	amino acid
AYP_001415	COG1760	l-serine dehydratase
AYP_001416	COG2030	dehydratase
AYP_001416	COG1012	belongs to the aldehyde dehydrogenase family
AYP_001417	COG3396	Phenylacetate-CoA oxygenase
AYP_001418	COG3460	Phenylacetate-CoA oxygenase
AYP_001419	COG3396	Phenylacetate-CoA oxygenase
AYP_001420	COG2151	metal-sulfur cluster biosynthetic enzyme
AYP_001421	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYP_001422	COG1024	Enoyl-CoA hydratase
AYP_001423	COG1024	Enoyl-CoA hydratase
AYP_001424	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYP_001425	COG0183	Belongs to the thiolase family
AYP_001426	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AYP_001427	COG3327	negative regulation of DNA-templated transcription, initiation
AYP_001429	COG2050	protein possibly involved in aromatic compounds catabolism
AYP_001436	COG0753	catalase activity
AYP_001437	COG3038	cytochrome b561
AYP_001441	COG2267	carboxylic ester hydrolase activity
AYP_001442	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_001443	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYP_001444	COG1012	belongs to the aldehyde dehydrogenase family
AYP_001446	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYP_001448	COG1012	belongs to the aldehyde dehydrogenase family
AYP_001449	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYP_001450	COG0583	DNA-binding transcription factor activity
AYP_001452	COG1414	Transcriptional regulator
AYP_001453	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_001455	COG1840	ABC-type Fe3 transport system, periplasmic component
AYP_001456	COG3842	ATPase activity
AYP_001462	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AYP_001463	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYP_001464	COG2814	Major facilitator Superfamily
AYP_001465	COG1960	acyl-CoA dehydrogenase activity
AYP_001468	COG1024	Enoyl-CoA hydratase
AYP_001470	COG2814	Major facilitator Superfamily
AYP_001472	COG0183	Belongs to the thiolase family
AYP_001473	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYP_001474	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_001475	COG1024	Enoyl-CoA hydratase
AYP_001476	COG1960	acyl-CoA dehydrogenase activity
AYP_001477	COG2814	Major facilitator Superfamily
AYP_001478	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYP_001479	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYP_001481	COG2814	Major facilitator Superfamily
AYP_001483	COG1960	acyl-CoA dehydrogenase activity
AYP_001486	COG0583	DNA-binding transcription factor activity
AYP_001489	COG1024	Enoyl-CoA hydratase
AYP_001490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYP_001491	COG1960	acyl-CoA dehydrogenase activity
AYP_001492	COG1309	transcriptional regulator
AYP_001493	COG0318	PFAM AMP-dependent synthetase and ligase
AYP_001497	COG0583	DNA-binding transcription factor activity
AYP_001507	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_001511	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYP_001516	COG2205	protein histidine kinase activity
AYP_001516	COG0784	Response regulator, receiver
AYP_001519	COG0765	amino acid transport
AYP_001520	COG0765	amino acid transport
AYP_001521	COG1126	abc transporter atp-binding protein
AYP_001522	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYP_001523	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYP_001526	COG1280	lysine exporter protein (LysE YggA)
AYP_001527	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AYP_001528	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYP_001529	COG1045	serine acetyltransferase
AYP_001532	COG0583	DNA-binding transcription factor activity
AYP_001533	COG0625	glutathione transferase activity
AYP_001534	COG0625	glutathione transferase activity
AYP_001535	COG0583	DNA-binding transcription factor activity
AYP_001537	COG1346	cytolysis
AYP_001541	COG2814	Major facilitator Superfamily
AYP_001544	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AYP_001545	COG3052	prosthetic group binding
AYP_001549	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AYP_001553	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_001555	COG1294	oxidase, subunit
AYP_001556	COG1271	oxidase subunit
AYP_001561	COG0477	Major facilitator Superfamily
AYP_001563	COG4521	taurine ABC transporter
AYP_001564	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AYP_001565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYP_001566	COG2175	clavaminate synthase activity
AYP_001568	COG1953	Uracil, thiamine, allantoin
AYP_001570	COG0583	DNA-binding transcription factor activity
AYP_001572	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AYP_001575	COG0640	Transcriptional regulator
AYP_001576	COG0798	PFAM Bile acid sodium symporter
AYP_001577	COG0583	DNA-binding transcription factor activity
AYP_001580	COG3634	alkyl hydroperoxide reductase activity
AYP_001589	COG0436	Aminotransferase
AYP_001591	COG0386	Belongs to the glutathione peroxidase family
AYP_001599	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYP_001604	COG0012	GTP binding
AYP_001605	COG2011	ABC-type metal ion transport system permease component
AYP_001606	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYP_001608	COG1464	Belongs to the NlpA lipoprotein family
AYP_001614	COG0765	amino acid transport
AYP_001615	COG0765	amino acid transport
AYP_001616	COG1126	abc transporter atp-binding protein
AYP_001618	COG1522	sequence-specific DNA binding
AYP_001621	COG1309	transcriptional regulator
AYP_001626	COG0583	DNA-binding transcription factor activity
AYP_001628	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AYP_001630	COG0697	spore germination
AYP_001635	COG3121	Chaperone
AYP_001636	COG3539	Fimbrial protein
AYP_001641	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AYP_001641	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AYP_001651	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AYP_001653	COG2353	YceI-like domain
AYP_001655	COG3698	Phosphodiester glycosidase
AYP_001658	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AYP_001659	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYP_001659	COG0506	proline dehydrogenase activity
AYP_001659	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AYP_001662	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYP_001663	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AYP_001667	COG1132	(ABC) transporter
AYP_001668	COG3122	Protein conserved in bacteria
AYP_001669	COG3619	membrane
AYP_001671	COG0640	Transcriptional regulator
AYP_001673	COG2850	peptidyl-arginine hydroxylation
AYP_001674	COG0424	maF-like protein
AYP_001678	COG0191	fructose-bisphosphate aldolase activity
AYP_001679	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYP_001682	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AYP_001684	COG1192	Involved in chromosome partitioning
AYP_001685	COG1475	DNA binding
AYP_001686	COG0811	peptide transport
AYP_001688	COG1132	(ABC) transporter
AYP_001689	COG1663	tetraacyldisaccharide 4'-kinase activity
AYP_001693	COG0084	hydrolase, TatD family'
AYP_001696	COG2165	general secretion pathway protein
AYP_001702	COG0590	tRNA wobble adenosine to inosine editing
AYP_001706	COG0776	regulation of translation
AYP_001712	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AYP_001713	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AYP_001722	COG0339	signal peptide processing
AYP_001724	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYP_001733	COG0702	epimerase
AYP_001734	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYP_001738	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AYP_001744	COG0316	Belongs to the HesB IscA family
AYP_001745	COG0822	iron-sulfur transferase activity
AYP_001750	COG0776	regulation of translation
AYP_001751	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AYP_001752	COG2207	Transcriptional regulator
AYP_001753	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYP_001754	COG1960	acyl-CoA dehydrogenase activity
AYP_001755	COG1960	acyl-CoA dehydrogenase activity
AYP_001758	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AYP_001762	COG4264	IucA IucC family
AYP_001763	COG4264	IucA IucC family
AYP_001775	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AYP_001779	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AYP_001780	COG0730	response to heat
AYP_001784	COG4773	Receptor
AYP_001785	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYP_001788	COG1131	(ABC) transporter
AYP_001789	COG0842	Transport permease protein
AYP_001790	COG0842	Transport permease protein
AYP_001802	COG2226	methyltransferase
AYP_001807	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AYP_001816	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYP_001818	COG0133	tryptophan synthase activity
AYP_001821	COG3706	GGDEF domain
AYP_001826	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYP_001827	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AYP_001828	COG0022	dehydrogenase e1 component
AYP_001829	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYP_001830	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYP_001832	COG1063	alcohol dehydrogenase
AYP_001833	COG3781	membrane
AYP_001835	COG3453	Protein conserved in bacteria
AYP_001835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYP_001837	COG0730	response to heat
AYP_001840	COG3708	Transcriptional regulator
AYP_001840	COG2207	Transcriptional regulator
AYP_001841	COG1733	regulation of RNA biosynthetic process
AYP_001842	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AYP_001847	COG4521	taurine ABC transporter
AYP_001848	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYP_001852	COG0477	Major facilitator Superfamily
AYP_001854	COG1027	Aspartate ammonia-lyase
AYP_001857	COG0583	DNA-binding transcription factor activity
AYP_001858	COG0583	DNA-binding transcription factor activity
AYP_001859	COG0183	Belongs to the thiolase family
AYP_001860	COG2031	fatty acid transporter
AYP_001861	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYP_001863	COG0583	DNA-binding transcription factor activity
AYP_001865	COG2610	gluconate transmembrane transporter activity
AYP_001866	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_001869	COG2207	Transcriptional regulator
AYP_001871	COG0412	Dienelactone hydrolase
AYP_001872	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_001874	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_001877	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYP_001877	COG0543	2 iron, 2 sulfur cluster binding
AYP_001878	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AYP_001879	COG4638	Rieske (2fe-2S)
AYP_001881	COG0725	ABC transporter, periplasmic molybdate-binding protein
AYP_001882	COG4149	molybdate abc transporter
AYP_001883	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AYP_001884	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_001885	COG3433	isochorismatase activity
AYP_001885	COG1535	isochorismatase
AYP_001897	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYP_001900	COG0753	catalase activity
AYP_001902	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AYP_001909	COG3539	Fimbrial protein
AYP_001912	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYP_001916	COG2072	flavoprotein involved in K transport
AYP_001918	COG1538	Outer membrane efflux protein
AYP_001919	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYP_001920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_001921	COG0745	RESPONSE REGULATOR receiver
AYP_001922	COG2205	protein histidine kinase activity
AYP_001924	COG2207	Transcriptional regulator
AYP_001927	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_001939	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AYP_001964	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYP_001971	COG1120	ATPase activity
AYP_001975	COG1064	alcohol dehydrogenase
AYP_001978	COG2207	Transcriptional regulator
AYP_001979	COG2084	Dehydrogenase
AYP_001981	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYP_001982	COG0583	DNA-binding transcription factor activity
AYP_001984	COG0129	dihydroxy-acid dehydratase activity
AYP_001985	COG1012	belongs to the aldehyde dehydrogenase family
AYP_001988	COG1566	PFAM secretion protein HlyD family protein
AYP_001992	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYP_001993	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYP_001998	COG0583	DNA-binding transcription factor activity
AYP_002008	COG3210	domain, Protein
AYP_002009	COG2831	hemolysin activation secretion protein
AYP_002012	COG1473	amidohydrolase
AYP_002014	COG0475	glutathione-regulated potassium exporter activity
AYP_002014	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AYP_002016	COG0583	DNA-binding transcription factor activity
AYP_002017	COG1335	isochorismatase
AYP_002019	COG1309	transcriptional regulator
AYP_002025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYP_002027	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_002027	COG1902	pentaerythritol trinitrate reductase activity
AYP_002028	COG1846	Transcriptional regulator
AYP_002033	COG0753	catalase activity
AYP_002036	COG1012	belongs to the aldehyde dehydrogenase family
AYP_002039	COG3162	membrane
AYP_002041	COG3829	transcription factor binding
AYP_002042	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_002043	COG1960	acyl-CoA dehydrogenase activity
AYP_002047	COG1012	belongs to the aldehyde dehydrogenase family
AYP_002051	COG2186	Transcriptional regulator
AYP_002053	COG0583	DNA-binding transcription factor activity
AYP_002054	COG4948	Mandelate Racemase Muconate Lactonizing
AYP_002055	COG4829	muconolactone delta-isomerase
AYP_002057	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYP_002058	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYP_002059	COG0183	Belongs to the thiolase family
AYP_002060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYP_002062	COG1012	belongs to the aldehyde dehydrogenase family
AYP_002064	COG3733	amine oxidase
AYP_002066	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_002068	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_002070	COG4638	Rieske (2fe-2S)
AYP_002074	COG0154	amidase activity
AYP_002076	COG2814	Major facilitator Superfamily
AYP_002081	COG1960	acyl-CoA dehydrogenase activity
AYP_002082	COG0583	DNA-binding transcription factor activity
AYP_002083	COG1414	Transcriptional regulator
AYP_002086	COG2391	methyltransferase activity
AYP_002088	COG4993	Dehydrogenase
AYP_002089	COG3659	wide pore channel activity
AYP_002090	COG3420	alginic acid biosynthetic process
AYP_002091	COG0710	3-dehydroquinate dehydratase activity
AYP_002092	COG3485	protocatechuate 3,4-dioxygenase
AYP_002093	COG3485	protocatechuate 3,4-dioxygenase
AYP_002094	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AYP_002095	COG2271	Major facilitator Superfamily
AYP_002096	COG0596	Alpha beta hydrolase
AYP_002097	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AYP_002098	COG0183	Belongs to the thiolase family
AYP_002099	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AYP_002100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AYP_002102	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AYP_002103	COG2323	membrane
AYP_002112	COG1902	pentaerythritol trinitrate reductase activity
AYP_002112	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYP_002115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AYP_002117	COG0542	response to heat
AYP_002118	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AYP_002125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYP_002126	COG0569	domain protein
AYP_002127	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AYP_002130	COG4774	siderophore transport
AYP_002131	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYP_002133	COG1585	Membrane protein implicated in regulation of membrane protease activity
AYP_002137	COG1294	oxidase, subunit
AYP_002140	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AYP_002142	COG0552	protein localization to endoplasmic reticulum
AYP_002147	COG0517	IMP dehydrogenase activity
AYP_002147	COG0516	GMP reductase activity
AYP_002148	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYP_002149	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AYP_002151	COG0583	DNA-binding transcription factor activity
AYP_002152	COG0024	Methionine aminopeptidase
AYP_002157	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYP_002157	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYP_002158	COG1105	Belongs to the carbohydrate kinase PfkB family
AYP_002159	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AYP_002159	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYP_002159	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AYP_002164	COG5001	Diguanylate cyclase
AYP_002164	COG3300	MHYT domain
AYP_002167	COG2135	peptidase activity
AYP_002168	COG0659	secondary active sulfate transmembrane transporter activity
AYP_002171	COG1113	amino acid transport
AYP_002173	COG1522	sequence-specific DNA binding
AYP_002178	COG1011	Hydrolase
AYP_002179	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AYP_002181	COG2137	regulation of response to DNA damage stimulus
AYP_002184	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYP_002191	COG0575	Belongs to the CDS family
AYP_002192	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYP_002197	COG3852	Histidine kinase
AYP_002198	COG2204	response regulator
AYP_002210	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AYP_002211	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AYP_002215	COG0697	spore germination
AYP_002216	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_002218	COG0303	'Molybdopterin
AYP_002219	COG0521	Mo-molybdopterin cofactor biosynthetic process
AYP_002219	COG0315	cyclic pyranopterin monophosphate synthase activity
AYP_002222	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AYP_002223	COG0243	molybdopterin cofactor binding
AYP_002225	COG0243	molybdopterin cofactor binding
AYP_002226	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_002227	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_002227	COG2146	nitrite reductase [NAD(P)H] activity
AYP_002228	COG0745	RESPONSE REGULATOR receiver
AYP_002229	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYP_002229	COG1116	anion transmembrane transporter activity
AYP_002232	COG0511	ligase activity, forming carbon-carbon bonds
AYP_002235	COG2814	Major facilitator Superfamily
AYP_002302	COG0069	glutamate synthase activity
AYP_002306	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYP_002308	COG1454	alcohol dehydrogenase
AYP_002309	COG0824	Thioesterase
AYP_002312	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AYP_002318	COG0183	Belongs to the thiolase family
AYP_002320	COG0583	DNA-binding transcription factor activity
AYP_002323	COG1522	sequence-specific DNA binding
AYP_002324	COG3135	benzoate transporter
AYP_002326	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYP_002330	COG0589	response to stress
AYP_002331	COG0488	(ABC) transporter
AYP_002336	COG4773	Receptor
AYP_002342	COG0668	transmembrane transport
AYP_002345	COG1309	transcriptional regulator
AYP_002348	COG1605	Chorismate mutase
AYP_002350	COG4221	oxidoreductase activity
AYP_002352	COG0308	aminopeptidase N
AYP_002356	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AYP_002358	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYP_002359	COG1454	alcohol dehydrogenase
AYP_002363	COG0531	amino acid
AYP_002364	COG4303	Ethanolamine ammonia lyase large subunit
AYP_002365	COG4302	ethanolamine ammonia-lyase activity
AYP_002366	COG0519	Catalyzes the synthesis of GMP from XMP
AYP_002366	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYP_002370	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AYP_002373	COG0697	spore germination
AYP_002374	COG1923	regulation of RNA biosynthetic process
AYP_002376	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AYP_002377	COG0802	atpase or kinase
AYP_002381	COG1187	pseudouridine synthase activity
AYP_002384	COG0583	DNA-binding transcription factor activity
AYP_002387	COG2814	Major facilitator Superfamily
AYP_002388	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AYP_002393	COG0729	surface antigen
AYP_002397	COG0174	glutamine synthetase
AYP_002398	COG0745	RESPONSE REGULATOR receiver
AYP_002399	COG2205	protein histidine kinase activity
AYP_002401	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AYP_002402	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AYP_002407	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_002408	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYP_002409	COG1960	acyl-CoA dehydrogenase activity
AYP_002412	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AYP_002413	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AYP_002417	COG0583	DNA-binding transcription factor activity
AYP_002420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYP_002422	COG3658	cytochrome
AYP_002423	COG1215	transferase activity, transferring glycosyl groups
AYP_002424	COG0726	polysaccharide deacetylase
AYP_002424	COG1649	PFAM Uncharacterised BCR, COG1649
AYP_002429	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AYP_002430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AYP_002432	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AYP_002437	COG0305	Participates in initiation and elongation during chromosome replication
AYP_002438	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYP_002440	COG1305	Transglutaminase-like
AYP_002442	COG2308	Evidence 4 Homologs of previously reported genes of
AYP_002450	COG0138	bifunctional purine biosynthesis protein purh
AYP_002451	COG0151	Belongs to the GarS family
AYP_002452	COG1464	Belongs to the NlpA lipoprotein family
AYP_002453	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYP_002454	COG2011	ABC-type metal ion transport system permease component
AYP_002455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYP_002457	COG1301	dicarboxylic acid transport
AYP_002463	COG1794	racemase activity, acting on amino acids and derivatives
AYP_002465	COG3008	intermembrane lipid transfer
AYP_002465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AYP_002466	COG2995	paraquat-inducible protein a
AYP_002468	COG2985	domain, Protein
AYP_002472	COG0477	Major facilitator Superfamily
AYP_002482	COG2186	Transcriptional regulator
AYP_002484	COG0786	glutamate:sodium symporter activity
AYP_002485	COG3243	poly(R)-hydroxyalkanoic acid synthase
AYP_002492	COG3111	PFAM Bacterial OB fold (BOF) protein
AYP_002509	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AYP_002510	COG1610	YqeY-like protein
AYP_002511	COG4783	chaperone-mediated protein folding
AYP_002522	COG0778	Nitroreductase
AYP_002524	COG0513	Belongs to the DEAD box helicase family
AYP_002528	COG2363	Small membrane protein
AYP_002534	COG1234	tRNA 3'-trailer cleavage
AYP_002535	COG2195	Cleaves the N-terminal amino acid of tripeptides
AYP_002537	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AYP_002539	COG2819	hydrolase of the alpha beta superfamily
AYP_002540	COG1960	acyl-CoA dehydrogenase activity
AYP_002541	COG1301	dicarboxylic acid transport
AYP_002542	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AYP_002543	COG3139	Protein of unknown function (DUF1315)
AYP_002544	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AYP_002545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYP_002547	COG0494	nUDIX hydrolase
AYP_002549	COG0642	Histidine kinase
AYP_002550	COG0745	RESPONSE REGULATOR receiver
AYP_002554	COG1720	tRNA m6t6A37 methyltransferase activity
AYP_002557	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_002559	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AYP_002561	COG4598	ABC transporter
AYP_002562	COG4160	amino acid transport
AYP_002563	COG4215	(ABC) transporter
AYP_002566	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_002568	COG1538	Outer membrane efflux protein
AYP_002575	COG1131	(ABC) transporter
AYP_002576	COG0842	Transport permease protein
AYP_002579	COG0772	Belongs to the SEDS family
AYP_002580	COG2951	lytic endotransglycosylase activity
AYP_002585	COG2207	Transcriptional regulator
AYP_002588	COG0052	Belongs to the universal ribosomal protein uS2 family
AYP_002589	COG0024	Methionine aminopeptidase
AYP_002591	COG2223	nitrite transmembrane transporter activity
AYP_002594	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYP_002595	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYP_002596	COG1960	acyl-CoA dehydrogenase activity
AYP_002599	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AYP_002600	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AYP_002601	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYP_002605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYP_002606	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYP_002607	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AYP_002614	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AYP_002617	COG3104	oligopeptide transport
AYP_002619	COG0512	Glutamine amidotransferase of anthranilate synthase
AYP_002632	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AYP_002640	COG3739	integral membrane protein
AYP_002643	COG1169	isochorismate synthase
AYP_002645	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AYP_002647	COG1132	(ABC) transporter
AYP_002650	COG3433	isochorismatase activity
AYP_002650	COG1535	isochorismatase
AYP_002651	COG1021	2,3-dihydroxybenzoate-AMP ligase
AYP_002652	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_002654	COG4774	siderophore transport
AYP_002655	COG4607	ABC-type enterochelin transport system periplasmic component
AYP_002656	COG4604	ABC transporter, ATP-binding protein
AYP_002657	COG4605	iron ion homeostasis
AYP_002658	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYP_002659	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_002662	COG2964	Protein conserved in bacteria
AYP_002665	COG1741	Belongs to the pirin family
AYP_002669	COG1309	transcriptional regulator
AYP_002671	COG4948	Mandelate Racemase Muconate Lactonizing
AYP_002672	COG2814	Major facilitator Superfamily
AYP_002679	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AYP_002679	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYP_002680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_002683	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_002684	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_002685	COG0583	DNA-binding transcription factor activity
AYP_002686	COG1113	amino acid transport
AYP_002690	COG2508	Transcriptional regulator
AYP_002690	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AYP_002696	COG2879	small protein
AYP_002697	COG1966	Carbon starvation protein
AYP_002706	COG1067	ATP-dependent peptidase activity
AYP_002707	COG0583	DNA-binding transcription factor activity
AYP_002712	COG1686	Belongs to the peptidase S11 family
AYP_002713	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AYP_002720	COG0616	signal peptide processing
AYP_002721	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AYP_002723	COG0573	inorganic phosphate transmembrane transporter activity
AYP_002724	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYP_002725	COG1113	amino acid transport
AYP_002726	COG3961	Belongs to the TPP enzyme family
AYP_002727	COG1522	sequence-specific DNA binding
AYP_002729	COG0076	glutamate decarboxylase activity
AYP_002730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYP_002732	COG1309	transcriptional regulator
AYP_002735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYP_002742	COG0352	thiamine-phosphate diphosphorylase activity
AYP_002747	COG0612	Peptidase, M16
AYP_002750	COG0583	DNA-binding transcription factor activity
AYP_002751	COG0477	Major facilitator Superfamily
AYP_002755	COG1187	pseudouridine synthase activity
AYP_002758	COG1686	Belongs to the peptidase S11 family
AYP_002759	COG1252	NADH dehydrogenase
AYP_002761	COG0415	Belongs to the DNA photolyase family
AYP_002764	COG1215	transferase activity, transferring glycosyl groups
AYP_002770	COG2070	2-Nitropropane dioxygenase
AYP_002809	COG5410	chromosome segregation
AYP_002850	COG0556	nucleotide-excision repair
AYP_002859	COG4221	oxidoreductase activity
AYP_002861	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AYP_002862	COG1381	Involved in DNA repair and RecF pathway recombination
AYP_002864	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AYP_002867	COG0681	Belongs to the peptidase S26 family
AYP_002870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYP_002874	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AYP_002875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AYP_002876	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AYP_002879	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AYP_002880	COG4208	sulfate ABC transporter
AYP_002881	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AYP_002882	COG0583	DNA-binding transcription factor activity
AYP_002883	COG4625	pathogenesis
AYP_002886	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AYP_002889	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AYP_002892	COG1024	Enoyl-CoA hydratase
AYP_002893	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYP_002896	COG2814	Major facilitator Superfamily
AYP_002897	COG0047	phosphoribosylformylglycinamidine synthase activity
AYP_002897	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AYP_002901	COG1473	amidohydrolase
AYP_002902	COG0824	Thioesterase
AYP_002906	COG0823	Involved in the tonB-independent uptake of proteins
AYP_002910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYP_002917	COG0628	permease
AYP_002919	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AYP_002920	COG0596	Alpha beta hydrolase
AYP_002921	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYP_002921	COG0616	signal peptide processing
AYP_002923	COG2333	competence protein COMEC
AYP_002923	COG0658	competence protein
AYP_002924	COG1136	(ABC) transporter
AYP_002925	COG4591	ABC-type transport system involved in lipoprotein release permease component
AYP_002933	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_002937	COG0463	Glycosyl transferase, family 2
AYP_002943	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AYP_002944	COG1280	lysine exporter protein (LysE YggA)
AYP_002946	COG0019	diaminopimelate decarboxylase activity
AYP_002948	COG1113	amino acid transport
AYP_002952	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AYP_002954	COG3339	Conserved Protein
AYP_002955	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AYP_002956	COG0243	molybdopterin cofactor binding
AYP_002957	COG1929	Belongs to the glycerate kinase type-1 family
AYP_002960	COG0778	Nitroreductase
AYP_002965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_002968	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYP_002972	COG0741	lytic transglycosylase activity
AYP_002976	COG0584	glycerophosphoryl diester phosphodiesterase
AYP_002977	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYP_002982	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AYP_002986	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYP_002987	COG0477	Major facilitator Superfamily
AYP_002997	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AYP_002998	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYP_003003	COG0505	Belongs to the CarA family
AYP_003007	COG0589	response to stress
AYP_003010	COG2843	Capsule synthesis protein
AYP_003015	COG2321	neutral zinc metallopeptidase
AYP_003016	COG2354	Protein conserved in bacteria
AYP_003020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYP_003024	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AYP_003025	COG1053	succinate dehydrogenase
AYP_003026	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AYP_003027	COG2009	succinate dehydrogenase
AYP_003037	COG2921	Belongs to the UPF0250 family
AYP_003038	COG0321	lipoyl(octanoyl) transferase activity
AYP_003041	COG0531	amino acid
AYP_003043	COG1733	regulation of RNA biosynthetic process
AYP_003044	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AYP_003045	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AYP_003045	COG1648	precorrin-2 dehydrogenase activity
AYP_003048	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AYP_003053	COG0671	phosphoesterase, PA-phosphatase related
AYP_003054	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_003056	COG1538	Outer membrane efflux protein
AYP_003057	COG0393	Putative heavy-metal-binding
AYP_003058	COG0393	Putative heavy-metal-binding
AYP_003060	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_003062	COG0525	valine-tRNA ligase activity
AYP_003066	COG0583	DNA-binding transcription factor activity
AYP_003067	COG0004	ammonium transporteR
AYP_003069	COG0642	Histidine kinase
AYP_003070	COG0745	RESPONSE REGULATOR receiver
AYP_003071	COG2194	sulfuric ester hydrolase activity
AYP_003075	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYP_003078	COG2315	Protein conserved in bacteria
AYP_003079	COG0142	geranyltranstransferase activity
AYP_003080	COG2828	Protein conserved in bacteria
AYP_003082	COG1113	amino acid transport
AYP_003086	COG2207	Transcriptional regulator
AYP_003093	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYP_003097	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AYP_003099	COG1530	ribonuclease E activity
AYP_003100	COG0424	maF-like protein
AYP_003101	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AYP_003102	COG1792	Involved in formation and maintenance of cell shape
AYP_003103	COG1077	Cell shape determining protein MreB Mrl
AYP_003104	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYP_003106	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYP_003112	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AYP_003113	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYP_003114	COG1752	Esterase of the alpha-beta hydrolase superfamily
AYP_003115	COG1115	amino acid carrier protein
AYP_003119	COG2814	Major facilitator Superfamily
AYP_003120	COG1289	transmembrane transporter activity
AYP_003130	COG1376	ErfK ybiS ycfS ynhG family protein
AYP_003131	COG2832	Protein of unknown function (DUF454)
AYP_003133	COG5510	response to toxic substance
AYP_003137	COG0840	transmembrane signaling receptor activity
AYP_003148	COG3422	double-strand break repair
AYP_003149	COG2824	Alkylphosphonate utilization operon protein PhnA
AYP_003150	COG3189	MarR family transcriptional regulator
AYP_003152	COG0354	folic acid binding
AYP_003153	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYP_003155	COG0679	Auxin Efflux Carrier
AYP_003156	COG1902	pentaerythritol trinitrate reductase activity
AYP_003157	COG4772	TonB-dependent receptor
AYP_003158	COG2094	Belongs to the DNA glycosylase MPG family
AYP_003165	COG2233	PERMEase
AYP_003167	COG0833	amino acid
AYP_003168	COG1690	Belongs to the RtcB family
AYP_003170	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AYP_003170	COG2885	chlorophyll binding
AYP_003172	COG0183	Belongs to the thiolase family
AYP_003178	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AYP_003183	COG2207	Transcriptional regulator
AYP_003184	COG0183	Belongs to the thiolase family
AYP_003191	COG1272	protein, Hemolysin III
AYP_003192	COG0477	Major facilitator Superfamily
AYP_003195	COG0450	alkyl hydroperoxide reductase
AYP_003199	COG0285	dihydrofolate synthase activity
AYP_003207	COG0133	tryptophan synthase activity
AYP_003210	COG2096	Adenosyltransferase
AYP_003214	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AYP_003215	COG0745	RESPONSE REGULATOR receiver
AYP_003216	COG2205	protein histidine kinase activity
AYP_003218	COG1960	acyl-CoA dehydrogenase activity
AYP_003219	COG1960	acyl-CoA dehydrogenase activity
AYP_003220	COG0583	DNA-binding transcription factor activity
AYP_003221	COG0625	glutathione transferase activity
AYP_003235	COG0438	transferase activity, transferring glycosyl groups
AYP_003236	COG0463	Glycosyl transferase, family 2
AYP_003237	COG0726	polysaccharide deacetylase
AYP_003241	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AYP_003242	COG2205	protein histidine kinase activity
AYP_003251	COG1862	Preprotein translocase
AYP_003253	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYP_003254	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AYP_003257	COG3781	membrane
AYP_003258	COG0613	PHP domain protein
AYP_003260	COG2350	Protein conserved in bacteria
AYP_003266	COG1607	acyl-coa hydrolase
AYP_003269	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYP_003269	COG3453	Protein conserved in bacteria
AYP_003278	COG2199	diguanylate cyclase activity
AYP_003280	COG1408	metallophosphoesterase
AYP_003281	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYP_003283	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AYP_003303	COG1196	nuclear chromosome segregation
AYP_003303	COG0741	lytic transglycosylase activity
AYP_003303	COG0739	heme binding
AYP_003306	COG1598	PFAM Uncharacterised protein family UPF0150
AYP_003327	COG5410	chromosome segregation
AYP_003360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AYP_003361	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYP_003364	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AYP_003366	COG2969	positive regulation of protein catabolic process
AYP_003370	COG1960	acyl-CoA dehydrogenase activity
AYP_003371	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYP_003374	COG1309	transcriptional regulator
AYP_003375	COG1960	acyl-CoA dehydrogenase activity
AYP_003384	COG1183	phosphatidylcholine synthase activity
AYP_003385	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AYP_003393	COG0741	lytic transglycosylase activity
AYP_003393	COG0739	heme binding
AYP_003393	COG1196	nuclear chromosome segregation
AYP_003395	COG1702	phosphate starvation-inducible protein PhoH
AYP_003402	COG1295	ribonuclease BN
AYP_003403	COG0697	spore germination
AYP_003404	COG2169	Transcriptional regulator
AYP_003405	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYP_003414	COG0557	exoribonuclease II activity
AYP_003415	COG0339	signal peptide processing
AYP_003416	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AYP_003422	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AYP_003423	COG1960	acyl-CoA dehydrogenase activity
AYP_003428	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AYP_003430	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AYP_003454	COG0626	cystathionine gamma-synthase activity
AYP_003455	COG0433	COG0433 Predicted ATPase
AYP_003456	COG1017	nitric oxide dioxygenase activity
AYP_003456	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AYP_003457	COG1959	2 iron, 2 sulfur cluster binding
AYP_003460	COG1301	dicarboxylic acid transport
AYP_003461	COG1946	Acyl-CoA thioesterase
AYP_003465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AYP_003466	COG1040	competence protein
AYP_003467	COG0494	nUDIX hydrolase
AYP_003469	COG0598	Magnesium transport protein CorA
AYP_003471	COG2854	intermembrane phospholipid transfer
AYP_003473	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AYP_003474	COG1127	ABC transporter
AYP_003476	COG0513	Belongs to the DEAD box helicase family
AYP_003480	COG0408	coproporphyrinogen oxidase activity
AYP_003483	COG1960	acyl-CoA dehydrogenase activity
AYP_003485	COG1983	PspC domain protein
AYP_003486	COG0517	IMP dehydrogenase activity
AYP_003495	COG0583	DNA-binding transcription factor activity
AYP_003503	COG1012	belongs to the aldehyde dehydrogenase family
AYP_003505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYP_003506	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AYP_003508	COG0833	amino acid
AYP_003514	COG1192	Involved in chromosome partitioning
AYP_003515	COG0628	permease
AYP_003517	COG1289	transmembrane transporter activity
AYP_003520	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYP_003521	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AYP_003523	COG0277	FAD linked oxidase domain protein
AYP_003524	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AYP_003529	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYP_003530	COG5380	lipid catabolic process
AYP_003534	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AYP_003544	COG0194	GDP metabolic process
AYP_003546	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYP_003551	COG3307	-O-antigen
AYP_003555	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AYP_003556	COG1704	LemA family
AYP_003558	COG0493	'glutamate synthase
AYP_003559	COG0069	glutamate synthase activity
AYP_003559	COG0067	glutamate synthase
AYP_003559	COG0070	glutamate synthase
AYP_003569	COG2226	methyltransferase
AYP_003572	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AYP_003573	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AYP_003582	COG0833	amino acid
AYP_003599	COG0488	(ABC) transporter
AYP_003601	COG4221	oxidoreductase activity
AYP_003602	COG0659	secondary active sulfate transmembrane transporter activity
AYP_003604	COG0745	RESPONSE REGULATOR receiver
AYP_003606	COG0427	acetyl-CoA hydrolase
AYP_003612	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AYP_003618	COG2329	Antibiotic biosynthesis monooxygenase
AYP_003621	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AYP_003635	COG2249	NAD(P)H dehydrogenase (quinone) activity
AYP_003636	COG1733	regulation of RNA biosynthetic process
AYP_003643	COG0667	Aldo Keto reductase
AYP_003647	COG0583	DNA-binding transcription factor activity
AYP_003648	COG2814	Major facilitator Superfamily
AYP_003654	COG1335	isochorismatase
AYP_003656	COG1012	belongs to the aldehyde dehydrogenase family
AYP_003657	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYP_003659	COG1113	amino acid transport
AYP_003661	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AYP_003664	COG2814	Major facilitator Superfamily
AYP_003666	COG0351	phosphomethylpyrimidine kinase
AYP_003666	COG0352	thiamine-phosphate diphosphorylase activity
AYP_003666	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYP_003670	COG1309	transcriptional regulator
AYP_003671	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AYP_003673	COG3706	GGDEF domain
AYP_003675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AYP_003677	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AYP_003678	COG3162	membrane
AYP_003679	COG0784	Response regulator, receiver
AYP_003679	COG2198	Histidine kinase
AYP_003679	COG2205	protein histidine kinase activity
AYP_003684	COG3328	transposase activity
AYP_003685	COG1522	sequence-specific DNA binding
AYP_003686	COG1335	isochorismatase
AYP_003687	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYP_003689	COG0668	transmembrane transport
AYP_003690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AYP_003691	COG1519	Transferase
AYP_003692	COG1902	pentaerythritol trinitrate reductase activity
AYP_003697	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AYP_003702	COG0426	domain, Protein
AYP_003702	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AYP_003703	COG4774	siderophore transport
AYP_003704	COG2119	membrane
AYP_003706	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYP_003708	COG4942	peptidase
AYP_003711	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AYP_003713	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AYP_003717	COG0189	ligase activity
AYP_003721	COG0708	Exodeoxyribonuclease III
AYP_003722	COG1393	Belongs to the ArsC family
AYP_003725	COG3706	GGDEF domain
AYP_003732	COG2351	hydroxyisourate hydrolase activity
AYP_003733	COG2233	PERMEase
AYP_003735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AYP_003737	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AYP_003738	COG1028	Short-chain dehydrogenase reductase Sdr
AYP_003741	COG3150	esterase
AYP_003744	COG1388	LysM domain
AYP_003744	COG0791	NLP P60 protein
AYP_003745	COG3501	Rhs element vgr protein
AYP_003747	COG2918	glutathione biosynthetic process
AYP_003750	COG2733	membrane
AYP_003751	COG0436	Aminotransferase
AYP_003752	COG0534	Mate efflux family protein
AYP_003767	COG0560	Phosphoserine phosphatase
AYP_003767	COG3830	Belongs to the UPF0237 family
AYP_003772	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AYP_003774	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AYP_003776	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYP_003777	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYP_003780	COG0010	Belongs to the arginase family
AYP_003786	COG2188	Transcriptional regulator
AYP_003788	COG0523	cobalamin synthesis protein
AYP_003790	COG1113	amino acid transport
AYP_003792	COG0625	glutathione transferase activity
AYP_003796	COG1683	Conserved Protein
AYP_003797	COG0534	Mate efflux family protein
AYP_003798	COG0385	Bile acid
AYP_003799	COG1335	isochorismatase
AYP_003800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYP_003804	COG2116	formate transmembrane transporter activity
AYP_003805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYP_003806	COG2133	pyrroloquinoline quinone binding
AYP_003807	COG2983	Belongs to the UPF0260 family
AYP_003811	COG1194	a g-specific adenine glycosylase
AYP_003814	COG2818	Glycosylase
AYP_003815	COG1064	alcohol dehydrogenase
AYP_003816	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYP_003819	COG0583	DNA-binding transcription factor activity
AYP_003820	COG0656	L-ascorbic acid biosynthetic process
AYP_003821	COG2814	Major facilitator Superfamily
AYP_003828	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AYP_003831	COG2233	PERMEase
AYP_003839	COG0733	neurotransmitter:sodium symporter activity
AYP_003848	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AYP_003852	COG0583	DNA-binding transcription factor activity
AYP_003858	COG2951	lytic endotransglycosylase activity
AYP_003859	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AYP_003863	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYP_003865	COG0671	phosphoesterase, PA-phosphatase related
AYP_003866	COG0861	Integral membrane protein TerC family
AYP_003868	COG0754	glutathionylspermidine amidase activity
AYP_003870	COG0402	S-adenosylhomocysteine deaminase activity
AYP_003874	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AYP_003875	COG1230	cation diffusion facilitator family transporter
AYP_003878	COG0706	membrane insertase activity
AYP_003881	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AYP_003894	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYP_003898	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AYP_003901	COG1388	LysM domain
AYP_003913	COG1063	alcohol dehydrogenase
AYP_003919	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AYP_003921	COG1979	alcohol dehydrogenase
AYP_003923	COG1902	pentaerythritol trinitrate reductase activity
AYP_003925	COG1309	transcriptional regulator
AYP_003933	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYP_003942	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYP_003943	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYP_003943	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AYP_003952	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYP_003952	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYP_003955	COG0587	DNA-directed DNA polymerase activity
AYP_003965	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AYP_003970	COG0194	GDP metabolic process
AYP_003976	COG0358	DNA primase activity