locus-tag	class	description
HIN86_00010	COG0592	DNA-directed DNA polymerase activity
HIN86_00020	COG0187	DNA topoisomerase II activity
HIN86_00030	COG0586	Pfam SNARE associated Golgi protein
HIN86_00035	COG0488	(ABC) transporter
HIN86_00060	COG0596	Alpha beta hydrolase
HIN86_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HIN86_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HIN86_00110	COG0733	neurotransmitter:sodium symporter activity
HIN86_00145	COG0583	DNA-binding transcription factor activity
HIN86_00150	COG2233	PERMEase
HIN86_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN86_00200	COG2814	Major facilitator Superfamily
HIN86_00205	COG0656	L-ascorbic acid biosynthetic process
HIN86_00210	COG0583	DNA-binding transcription factor activity
HIN86_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN86_00230	COG1064	alcohol dehydrogenase
HIN86_00235	COG2818	Glycosylase
HIN86_00250	COG1194	a g-specific adenine glycosylase
HIN86_00270	COG2983	Belongs to the UPF0260 family
HIN86_00275	COG2133	pyrroloquinoline quinone binding
HIN86_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HIN86_00285	COG2116	formate transmembrane transporter activity
HIN86_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN86_00310	COG1335	isochorismatase
HIN86_00315	COG0385	Bile acid
HIN86_00320	COG0534	Mate efflux family protein
HIN86_00325	COG1683	Conserved Protein
HIN86_00345	COG0625	glutathione transferase activity
HIN86_00355	COG1113	amino acid transport
HIN86_00365	COG0523	cobalamin synthesis protein
HIN86_00375	COG2188	Transcriptional regulator
HIN86_00405	COG0010	Belongs to the arginase family
HIN86_00415	COG0546	phosphoglycolate phosphatase activity
HIN86_00420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HIN86_00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HIN86_00435	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HIN86_00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HIN86_00525	COG0534	Mate efflux family protein
HIN86_00530	COG0436	Aminotransferase
HIN86_00535	COG2733	membrane
HIN86_00550	COG2918	glutathione biosynthetic process
HIN86_00560	COG3501	Rhs element vgr protein
HIN86_00620	COG3150	esterase
HIN86_00630	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HIN86_00640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN86_00650	COG2233	PERMEase
HIN86_00655	COG2351	hydroxyisourate hydrolase activity
HIN86_00690	COG3706	GGDEF domain
HIN86_00705	COG1393	Belongs to the ArsC family
HIN86_00710	COG0708	Exodeoxyribonuclease III
HIN86_00730	COG0189	ligase activity
HIN86_00750	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HIN86_00760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HIN86_00775	COG4942	peptidase
HIN86_00785	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIN86_00795	COG2119	membrane
HIN86_00800	COG4774	siderophore transport
HIN86_00805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN86_00805	COG0426	domain, Protein
HIN86_00830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HIN86_00850	COG1902	pentaerythritol trinitrate reductase activity
HIN86_00855	COG1519	Transferase
HIN86_00860	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HIN86_00865	COG0668	transmembrane transport
HIN86_00875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIN86_00880	COG1335	isochorismatase
HIN86_00885	COG1522	sequence-specific DNA binding
HIN86_00910	COG0784	Response regulator, receiver
HIN86_00910	COG2198	Histidine kinase
HIN86_00910	COG2205	protein histidine kinase activity
HIN86_00915	COG3162	membrane
HIN86_00920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HIN86_00930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HIN86_00940	COG3706	GGDEF domain
HIN86_00945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HIN86_00950	COG1309	transcriptional regulator
HIN86_00970	COG0351	phosphomethylpyrimidine kinase
HIN86_00970	COG0352	thiamine-phosphate diphosphorylase activity
HIN86_00970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HIN86_00980	COG2814	Major facilitator Superfamily
HIN86_01045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HIN86_01055	COG1113	amino acid transport
HIN86_01065	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HIN86_01070	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_01080	COG1335	isochorismatase
HIN86_01110	COG2814	Major facilitator Superfamily
HIN86_01115	COG0583	DNA-binding transcription factor activity
HIN86_01135	COG0667	Aldo Keto reductase
HIN86_01175	COG1733	regulation of RNA biosynthetic process
HIN86_01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIN86_01245	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HIN86_01270	COG1132	(ABC) transporter
HIN86_01290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HIN86_01320	COG0427	acetyl-CoA hydrolase
HIN86_01335	COG0745	RESPONSE REGULATOR receiver
HIN86_01345	COG0659	secondary active sulfate transmembrane transporter activity
HIN86_01350	COG4221	oxidoreductase activity
HIN86_01355	COG2873	o-acetylhomoserine
HIN86_01360	COG0488	(ABC) transporter
HIN86_01425	COG0833	amino acid
HIN86_01470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HIN86_01475	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HIN86_01490	COG2226	methyltransferase
HIN86_01540	COG0069	glutamate synthase activity
HIN86_01540	COG0067	glutamate synthase
HIN86_01540	COG0070	glutamate synthase
HIN86_01545	COG0493	'glutamate synthase
HIN86_01555	COG1704	LemA family
HIN86_01560	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HIN86_01580	COG3307	-O-antigen
HIN86_01600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIN86_01615	COG0194	GDP metabolic process
HIN86_01665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HIN86_01685	COG5380	lipid catabolic process
HIN86_01690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HIN86_01715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HIN86_01720	COG0277	FAD linked oxidase domain protein
HIN86_01730	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HIN86_01735	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIN86_01750	COG1289	transmembrane transporter activity
HIN86_01760	COG0628	permease
HIN86_01765	COG1192	Involved in chromosome partitioning
HIN86_01795	COG0833	amino acid
HIN86_01800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HIN86_01805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HIN86_01815	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_01855	COG0583	DNA-binding transcription factor activity
HIN86_01895	COG0517	IMP dehydrogenase activity
HIN86_01900	COG1983	PspC domain protein
HIN86_01910	COG1960	acyl-CoA dehydrogenase activity
HIN86_01925	COG0408	coproporphyrinogen oxidase activity
HIN86_01945	COG0513	Belongs to the DEAD box helicase family
HIN86_01955	COG1127	ABC transporter
HIN86_01960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HIN86_01970	COG2854	intermembrane phospholipid transfer
HIN86_01980	COG0598	Magnesium transport protein CorA
HIN86_01990	COG0494	nUDIX hydrolase
HIN86_01995	COG1040	competence protein
HIN86_02000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HIN86_02020	COG1946	Acyl-CoA thioesterase
HIN86_02025	COG1301	dicarboxylic acid transport
HIN86_02040	COG1959	2 iron, 2 sulfur cluster binding
HIN86_02045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN86_02045	COG1017	nitric oxide dioxygenase activity
HIN86_02050	COG0433	COG0433 Predicted ATPase
HIN86_02055	COG0626	cystathionine gamma-synthase activity
HIN86_02210	COG1960	acyl-CoA dehydrogenase activity
HIN86_02215	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HIN86_02245	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HIN86_02250	COG0339	signal peptide processing
HIN86_02255	COG0557	exoribonuclease II activity
HIN86_02300	COG0179	Fumarylacetoacetate (FAA) hydrolase
HIN86_02305	COG2169	Transcriptional regulator
HIN86_02310	COG0697	spore germination
HIN86_02315	COG1295	ribonuclease BN
HIN86_02350	COG1702	phosphate starvation-inducible protein PhoH
HIN86_02360	COG0739	heme binding
HIN86_02360	COG1196	nuclear chromosome segregation
HIN86_02360	COG0741	lytic transglycosylase activity
HIN86_02390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HIN86_02395	COG1183	phosphatidylcholine synthase activity
HIN86_02440	COG1960	acyl-CoA dehydrogenase activity
HIN86_02445	COG1309	transcriptional regulator
HIN86_02460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HIN86_02465	COG1960	acyl-CoA dehydrogenase activity
HIN86_02470	COG1024	Enoyl-CoA hydratase
HIN86_02485	COG2969	positive regulation of protein catabolic process
HIN86_02495	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HIN86_02505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HIN86_02510	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HIN86_02515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HIN86_02535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HIN86_02545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIN86_02550	COG1408	metallophosphoesterase
HIN86_02560	COG2199	diguanylate cyclase activity
HIN86_02620	COG1607	acyl-coa hydrolase
HIN86_02650	COG2350	Protein conserved in bacteria
HIN86_02660	COG0613	PHP domain protein
HIN86_02665	COG3781	membrane
HIN86_02675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HIN86_02680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HIN86_02690	COG1862	Preprotein translocase
HIN86_02735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HIN86_02750	COG0726	polysaccharide deacetylase
HIN86_02755	COG0438	transferase activity, transferring glycosyl groups
HIN86_02775	COG0438	transferase activity, transferring glycosyl groups
HIN86_02780	COG1216	Glycosyl transferase, family 2
HIN86_02785	COG0438	transferase activity, transferring glycosyl groups
HIN86_02830	COG1960	acyl-CoA dehydrogenase activity
HIN86_02835	COG1960	acyl-CoA dehydrogenase activity
HIN86_02845	COG2205	protein histidine kinase activity
HIN86_02850	COG0745	RESPONSE REGULATOR receiver
HIN86_02855	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HIN86_02870	COG0584	glycerophosphoryl diester phosphodiesterase
HIN86_02875	COG2096	Adenosyltransferase
HIN86_02880	COG4206	TonB-dependent receptor
HIN86_02925	COG0285	dihydrofolate synthase activity
HIN86_02945	COG0450	alkyl hydroperoxide reductase
HIN86_02960	COG0477	Major facilitator Superfamily
HIN86_02965	COG1272	protein, Hemolysin III
HIN86_02995	COG0183	Belongs to the thiolase family
HIN86_03000	COG2207	Transcriptional regulator
HIN86_03020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN86_03040	COG0183	Belongs to the thiolase family
HIN86_03050	COG2885	chlorophyll binding
HIN86_03050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HIN86_03060	COG1690	Belongs to the RtcB family
HIN86_03065	COG0833	amino acid
HIN86_03075	COG2233	PERMEase
HIN86_03105	COG2094	Belongs to the DNA glycosylase MPG family
HIN86_03110	COG4772	TonB-dependent receptor
HIN86_03115	COG1902	pentaerythritol trinitrate reductase activity
HIN86_03130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIN86_03135	COG0354	folic acid binding
HIN86_03145	COG3189	MarR family transcriptional regulator
HIN86_03150	COG2824	Alkylphosphonate utilization operon protein PhnA
HIN86_03155	COG3422	double-strand break repair
HIN86_03195	COG0840	transmembrane signaling receptor activity
HIN86_03215	COG5510	response to toxic substance
HIN86_03225	COG2832	Protein of unknown function (DUF454)
HIN86_03230	COG1376	ErfK ybiS ycfS ynhG family protein
HIN86_03270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HIN86_03280	COG1289	transmembrane transporter activity
HIN86_03285	COG2814	Major facilitator Superfamily
HIN86_03305	COG1115	amino acid carrier protein
HIN86_03310	COG1752	Esterase of the alpha-beta hydrolase superfamily
HIN86_03315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HIN86_03320	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HIN86_03345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIN86_03355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIN86_03360	COG1077	Cell shape determining protein MreB Mrl
HIN86_03365	COG1792	Involved in formation and maintenance of cell shape
HIN86_03370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HIN86_03375	COG0424	maF-like protein
HIN86_03380	COG1530	ribonuclease E activity
HIN86_03390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN86_03400	COG0560	Phosphoserine phosphatase
HIN86_03410	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIN86_03435	COG2207	Transcriptional regulator
HIN86_03505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIN86_03690	COG0582	viral genome integration into host DNA
HIN86_03700	COG1113	amino acid transport
HIN86_03705	COG2828	Protein conserved in bacteria
HIN86_03710	COG0142	geranyltranstransferase activity
HIN86_03715	COG2315	Protein conserved in bacteria
HIN86_03730	COG1752	Esterase of the alpha-beta hydrolase superfamily
HIN86_03750	COG2194	sulfuric ester hydrolase activity
HIN86_03755	COG0745	RESPONSE REGULATOR receiver
HIN86_03760	COG0642	Histidine kinase
HIN86_03770	COG0004	ammonium transporteR
HIN86_03775	COG0583	DNA-binding transcription factor activity
HIN86_03795	COG0525	valine-tRNA ligase activity
HIN86_03805	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_03815	COG0393	Putative heavy-metal-binding
HIN86_03820	COG0393	Putative heavy-metal-binding
HIN86_03825	COG1538	Outer membrane efflux protein
HIN86_03835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN86_03840	COG0671	phosphoesterase, PA-phosphatase related
HIN86_03870	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HIN86_03885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HIN86_03885	COG1648	precorrin-2 dehydrogenase activity
HIN86_03890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HIN86_03895	COG1733	regulation of RNA biosynthetic process
HIN86_03905	COG0531	amino acid
HIN86_03920	COG0321	lipoyl(octanoyl) transferase activity
HIN86_03925	COG2921	Belongs to the UPF0250 family
HIN86_03960	COG2009	succinate dehydrogenase
HIN86_03965	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HIN86_03970	COG1053	succinate dehydrogenase
HIN86_03975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HIN86_04000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIN86_04020	COG2354	Protein conserved in bacteria
HIN86_04025	COG2321	neutral zinc metallopeptidase
HIN86_04045	COG2843	Capsule synthesis protein
HIN86_04060	COG0589	response to stress
HIN86_04080	COG0505	Belongs to the CarA family
HIN86_04105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HIN86_04110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HIN86_04160	COG0477	Major facilitator Superfamily
HIN86_04165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HIN86_04180	COG1597	lipid kinase activity
HIN86_04185	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HIN86_04260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN86_04265	COG0584	glycerophosphoryl diester phosphodiesterase
HIN86_04285	COG0741	lytic transglycosylase activity
HIN86_04305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HIN86_04320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN86_04335	COG0789	Transcriptional regulator
HIN86_04375	COG0778	Nitroreductase
HIN86_04390	COG1929	Belongs to the glycerate kinase type-1 family
HIN86_04395	COG0243	molybdopterin cofactor binding
HIN86_04400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HIN86_04405	COG3339	Conserved Protein
HIN86_04415	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HIN86_04430	COG1113	amino acid transport
HIN86_04440	COG0019	diaminopimelate decarboxylase activity
HIN86_04450	COG1280	lysine exporter protein (LysE YggA)
HIN86_04455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HIN86_04485	COG0463	Glycosyl transferase, family 2
HIN86_04505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN86_04540	COG4591	ABC-type transport system involved in lipoprotein release permease component
HIN86_04545	COG1136	(ABC) transporter
HIN86_04550	COG2333	competence protein COMEC
HIN86_04550	COG0658	competence protein
HIN86_04560	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HIN86_04560	COG0616	signal peptide processing
HIN86_04565	COG0596	Alpha beta hydrolase
HIN86_04570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HIN86_04580	COG0628	permease
HIN86_04615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIN86_04635	COG0823	Involved in the tonB-independent uptake of proteins
HIN86_04655	COG0824	Thioesterase
HIN86_04660	COG1473	amidohydrolase
HIN86_04680	COG0047	phosphoribosylformylglycinamidine synthase activity
HIN86_04680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIN86_04685	COG2814	Major facilitator Superfamily
HIN86_04695	COG1024	Enoyl-CoA hydratase
HIN86_04700	COG1056	cytidyltransferase-related domain
HIN86_04700	COG1051	belongs to the nudix hydrolase family
HIN86_04710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HIN86_04725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HIN86_04740	COG4625	pathogenesis
HIN86_04745	COG0583	DNA-binding transcription factor activity
HIN86_04750	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HIN86_04755	COG4208	sulfate ABC transporter
HIN86_04760	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HIN86_04770	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HIN86_04775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HIN86_04780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HIN86_04800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HIN86_04810	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HIN86_04820	COG0681	Belongs to the peptidase S26 family
HIN86_04835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HIN86_04845	COG1381	Involved in DNA repair and RecF pathway recombination
HIN86_04850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HIN86_04860	COG4221	oxidoreductase activity
HIN86_04890	COG0436	Aminotransferase
HIN86_04910	COG0556	nucleotide-excision repair
HIN86_04965	COG2070	2-Nitropropane dioxygenase
HIN86_04995	COG1215	transferase activity, transferring glycosyl groups
HIN86_05010	COG0415	Belongs to the DNA photolyase family
HIN86_05020	COG1252	NADH dehydrogenase
HIN86_05025	COG1686	Belongs to the peptidase S11 family
HIN86_05040	COG1187	pseudouridine synthase activity
HIN86_05065	COG0477	Major facilitator Superfamily
HIN86_05070	COG0583	DNA-binding transcription factor activity
HIN86_05085	COG0612	Peptidase, M16
HIN86_05110	COG0352	thiamine-phosphate diphosphorylase activity
HIN86_05145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN86_05170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HIN86_05175	COG0076	glutamate decarboxylase activity
HIN86_05185	COG1522	sequence-specific DNA binding
HIN86_05190	COG3961	Belongs to the TPP enzyme family
HIN86_05195	COG1113	amino acid transport
HIN86_05200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HIN86_05205	COG0573	inorganic phosphate transmembrane transporter activity
HIN86_05215	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HIN86_05220	COG0616	signal peptide processing
HIN86_05255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HIN86_05260	COG1686	Belongs to the peptidase S11 family
HIN86_05285	COG0583	DNA-binding transcription factor activity
HIN86_05290	COG1067	ATP-dependent peptidase activity
HIN86_05315	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HIN86_05335	COG1966	Carbon starvation protein
HIN86_05340	COG2879	small protein
HIN86_05360	COG1741	Belongs to the pirin family
HIN86_05370	COG2964	Protein conserved in bacteria
HIN86_05385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN86_05390	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HIN86_05395	COG4605	iron ion homeostasis
HIN86_05400	COG4604	ABC transporter, ATP-binding protein
HIN86_05405	COG4607	ABC-type enterochelin transport system periplasmic component
HIN86_05410	COG4774	siderophore transport
HIN86_05420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN86_05425	COG1021	2,3-dihydroxybenzoate-AMP ligase
HIN86_05430	COG3433	isochorismatase activity
HIN86_05430	COG1535	isochorismatase
HIN86_05445	COG1132	(ABC) transporter
HIN86_05450	COG5265	(ABC) transporter
HIN86_05455	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HIN86_05465	COG1169	isochorismate synthase
HIN86_05480	COG3739	integral membrane protein
HIN86_05510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HIN86_05540	COG0308	aminopeptidase N
HIN86_05545	COG0512	Glutamine amidotransferase of anthranilate synthase
HIN86_05700	COG5410	chromosome segregation
HIN86_05705	COG3567	Phage-associated protein, HI1409 family
HIN86_05725	COG3566	protein conserved in bacteria
HIN86_05805	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HIN86_05845	COG0582	viral genome integration into host DNA
HIN86_05855	COG3104	oligopeptide transport
HIN86_05860	COG0174	glutamine synthetase
HIN86_05870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HIN86_05905	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HIN86_05910	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HIN86_05915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HIN86_05935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HIN86_05940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HIN86_05945	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HIN86_05960	COG1960	acyl-CoA dehydrogenase activity
HIN86_05965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HIN86_05970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIN86_05980	COG2223	nitrite transmembrane transporter activity
HIN86_05990	COG0024	Methionine aminopeptidase
HIN86_05995	COG0052	Belongs to the universal ribosomal protein uS2 family
HIN86_06010	COG2207	Transcriptional regulator
HIN86_06035	COG2951	lytic endotransglycosylase activity
HIN86_06040	COG0772	Belongs to the SEDS family
HIN86_06055	COG0842	Transport permease protein
HIN86_06060	COG1131	(ABC) transporter
HIN86_06065	COG0582	viral genome integration into host DNA
HIN86_06120	COG2932	Transcriptional regulator
HIN86_06340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN86_06355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIN86_06365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN86_06380	COG1720	tRNA m6t6A37 methyltransferase activity
HIN86_06395	COG3111	PFAM Bacterial OB fold (BOF) protein
HIN86_06400	COG0745	RESPONSE REGULATOR receiver
HIN86_06405	COG0642	Histidine kinase
HIN86_06415	COG0494	nUDIX hydrolase
HIN86_06425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HIN86_06430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HIN86_06435	COG3139	Protein of unknown function (DUF1315)
HIN86_06440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HIN86_06445	COG1301	dicarboxylic acid transport
HIN86_06450	COG1960	acyl-CoA dehydrogenase activity
HIN86_06455	COG2819	hydrolase of the alpha beta superfamily
HIN86_06465	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HIN86_06475	COG2195	Cleaves the N-terminal amino acid of tripeptides
HIN86_06480	COG1234	tRNA 3'-trailer cleavage
HIN86_06510	COG2363	Small membrane protein
HIN86_06530	COG0513	Belongs to the DEAD box helicase family
HIN86_06540	COG0778	Nitroreductase
HIN86_06570	COG1286	toxin biosynthetic process
HIN86_06595	COG4783	chaperone-mediated protein folding
HIN86_06600	COG1610	YqeY-like protein
HIN86_06655	COG2831	hemolysin activation secretion protein
HIN86_06680	COG3210	domain, Protein
HIN86_06745	COG3111	PFAM Bacterial OB fold (BOF) protein
HIN86_06770	COG3243	poly(R)-hydroxyalkanoic acid synthase
HIN86_06775	COG0786	glutamate:sodium symporter activity
HIN86_06785	COG2186	Transcriptional regulator
HIN86_06835	COG0477	Major facilitator Superfamily
HIN86_06865	COG2995	paraquat-inducible protein a
HIN86_06870	COG3008	intermembrane lipid transfer
HIN86_06870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HIN86_06880	COG2351	hydroxyisourate hydrolase activity
HIN86_06920	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIN86_06930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIN86_06935	COG0642	Histidine kinase
HIN86_06940	COG0745	RESPONSE REGULATOR receiver
HIN86_06960	COG1794	racemase activity, acting on amino acids and derivatives
HIN86_06990	COG1301	dicarboxylic acid transport
HIN86_07000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN86_07005	COG2011	ABC-type metal ion transport system permease component
HIN86_07010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HIN86_07015	COG1464	Belongs to the NlpA lipoprotein family
HIN86_07020	COG0151	Belongs to the GarS family
HIN86_07025	COG0138	bifunctional purine biosynthesis protein purh
HIN86_07030	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HIN86_07060	COG2308	Evidence 4 Homologs of previously reported genes of
HIN86_07070	COG1305	Transglutaminase-like
HIN86_07080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HIN86_07085	COG0305	Participates in initiation and elongation during chromosome replication
HIN86_07110	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HIN86_07120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HIN86_07125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HIN86_07150	COG0726	polysaccharide deacetylase
HIN86_07150	COG1649	PFAM Uncharacterised BCR, COG1649
HIN86_07155	COG1215	transferase activity, transferring glycosyl groups
HIN86_07160	COG3658	cytochrome
HIN86_07170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN86_07185	COG0583	DNA-binding transcription factor activity
HIN86_07205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN86_07210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN86_07225	COG1960	acyl-CoA dehydrogenase activity
HIN86_07230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIN86_07235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN86_07260	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HIN86_07265	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HIN86_07270	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HIN86_07275	COG2205	protein histidine kinase activity
HIN86_07280	COG0745	RESPONSE REGULATOR receiver
HIN86_07285	COG0174	glutamine synthetase
HIN86_07305	COG0729	surface antigen
HIN86_07330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HIN86_07335	COG2814	Major facilitator Superfamily
HIN86_07350	COG0583	DNA-binding transcription factor activity
HIN86_07365	COG1187	pseudouridine synthase activity
HIN86_07385	COG0802	atpase or kinase
HIN86_07390	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HIN86_07400	COG1923	regulation of RNA biosynthetic process
HIN86_07405	COG0697	spore germination
HIN86_07430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIN86_07435	COG0519	Catalyzes the synthesis of GMP from XMP
HIN86_07435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HIN86_07445	COG4303	Ethanolamine ammonia lyase large subunit
HIN86_07450	COG0531	amino acid
HIN86_07470	COG1454	alcohol dehydrogenase
HIN86_07475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN86_07485	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HIN86_07505	COG0308	aminopeptidase N
HIN86_07545	COG1605	Chorismate mutase
HIN86_07560	COG1309	transcriptional regulator
HIN86_07570	COG0668	transmembrane transport
HIN86_07600	COG4773	Receptor
HIN86_07620	COG0488	(ABC) transporter
HIN86_07625	COG0589	response to stress
HIN86_07650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HIN86_07660	COG3135	benzoate transporter
HIN86_07665	COG1522	sequence-specific DNA binding
HIN86_07675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HIN86_07680	COG0583	DNA-binding transcription factor activity
HIN86_07690	COG0183	Belongs to the thiolase family
HIN86_07700	COG2030	dehydratase
HIN86_07730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HIN86_07740	COG0824	Thioesterase
HIN86_07745	COG1454	alcohol dehydrogenase
HIN86_07755	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HIN86_07775	COG0069	glutamate synthase activity
HIN86_07835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIN86_07915	COG1484	DNA-dependent DNA replication
HIN86_07990	COG3755	Protein conserved in bacteria
HIN86_08160	COG0592	DNA-directed DNA polymerase activity
HIN86_08195	COG4372	Transposase
HIN86_08290	COG2814	Major facilitator Superfamily
HIN86_08305	COG0511	ligase activity, forming carbon-carbon bonds
HIN86_08320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN86_08320	COG1116	anion transmembrane transporter activity
HIN86_08325	COG0745	RESPONSE REGULATOR receiver
HIN86_08335	COG2146	nitrite reductase [NAD(P)H] activity
HIN86_08335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN86_08340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN86_08345	COG0243	molybdopterin cofactor binding
HIN86_08355	COG0243	molybdopterin cofactor binding
HIN86_08360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HIN86_08375	COG0315	cyclic pyranopterin monophosphate synthase activity
HIN86_08375	COG0521	Mo-molybdopterin cofactor biosynthetic process
HIN86_08380	COG0303	'Molybdopterin
HIN86_08390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN86_08395	COG0697	spore germination
HIN86_08415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HIN86_08420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIN86_08475	COG2204	response regulator
HIN86_08480	COG3852	Histidine kinase
HIN86_08500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HIN86_08505	COG0575	Belongs to the CDS family
HIN86_08520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIN86_08540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIN86_08555	COG2137	regulation of response to DNA damage stimulus
HIN86_08565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HIN86_08570	COG1011	Hydrolase
HIN86_08595	COG1522	sequence-specific DNA binding
HIN86_08605	COG1113	amino acid transport
HIN86_08620	COG0659	secondary active sulfate transmembrane transporter activity
HIN86_08625	COG2135	peptidase activity
HIN86_08640	COG3300	MHYT domain
HIN86_08640	COG5001	Diguanylate cyclase
HIN86_08655	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HIN86_08655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIN86_08655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIN86_08660	COG1105	Belongs to the carbohydrate kinase PfkB family
HIN86_08665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIN86_08665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HIN86_08695	COG0024	Methionine aminopeptidase
HIN86_08700	COG0583	DNA-binding transcription factor activity
HIN86_08710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HIN86_08715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HIN86_08720	COG0516	GMP reductase activity
HIN86_08720	COG0517	IMP dehydrogenase activity
HIN86_08745	COG0552	protein localization to endoplasmic reticulum
HIN86_08755	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HIN86_08770	COG4890	Cyd operon protein YbgT
HIN86_08775	COG1294	oxidase, subunit
HIN86_08790	COG1585	Membrane protein implicated in regulation of membrane protease activity
HIN86_08800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIN86_08820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HIN86_08825	COG0569	domain protein
HIN86_08830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HIN86_08860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HIN86_08865	COG0542	response to heat
HIN86_08890	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIN86_08890	COG1902	pentaerythritol trinitrate reductase activity
HIN86_08935	COG2323	membrane
HIN86_08940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HIN86_08950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HIN86_08955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HIN86_08960	COG0183	Belongs to the thiolase family
HIN86_08965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HIN86_08970	COG0596	Alpha beta hydrolase
HIN86_08975	COG2271	Major facilitator Superfamily
HIN86_08980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HIN86_08985	COG3485	protocatechuate 3,4-dioxygenase
HIN86_08990	COG3485	protocatechuate 3,4-dioxygenase
HIN86_08995	COG0710	3-dehydroquinate dehydratase activity
HIN86_09000	COG3420	alginic acid biosynthetic process
HIN86_09005	COG3659	wide pore channel activity
HIN86_09010	COG4993	Dehydrogenase
HIN86_09020	COG2391	methyltransferase activity
HIN86_09035	COG1414	Transcriptional regulator
HIN86_09040	COG0583	DNA-binding transcription factor activity
HIN86_09045	COG1960	acyl-CoA dehydrogenase activity
HIN86_09070	COG2814	Major facilitator Superfamily
HIN86_09080	COG0154	amidase activity
HIN86_09100	COG4638	Rieske (2fe-2S)
HIN86_09110	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_09120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN86_09130	COG3733	amine oxidase
HIN86_09140	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_09150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIN86_09155	COG0183	Belongs to the thiolase family
HIN86_09160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HIN86_09165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HIN86_09175	COG4829	muconolactone delta-isomerase
HIN86_09180	COG4948	Mandelate Racemase Muconate Lactonizing
HIN86_09185	COG0583	DNA-binding transcription factor activity
HIN86_09195	COG2186	Transcriptional regulator
HIN86_09215	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_09230	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIN86_09230	COG1902	pentaerythritol trinitrate reductase activity
HIN86_09270	COG1309	transcriptional regulator
HIN86_09280	COG1335	isochorismatase
HIN86_09285	COG0583	DNA-binding transcription factor activity
HIN86_09295	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HIN86_09295	COG0475	glutathione-regulated potassium exporter activity
HIN86_09305	COG1473	amidohydrolase
HIN86_09315	COG2831	hemolysin activation secretion protein
HIN86_09320	COG3210	domain, Protein
HIN86_09350	COG2188	Transcriptional regulator
HIN86_09365	COG0583	DNA-binding transcription factor activity
HIN86_09405	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_09410	COG0129	dihydroxy-acid dehydratase activity
HIN86_09420	COG0583	DNA-binding transcription factor activity
HIN86_09425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIN86_09435	COG2084	Dehydrogenase
HIN86_09440	COG2207	Transcriptional regulator
HIN86_09455	COG1064	alcohol dehydrogenase
HIN86_09470	COG1120	ATPase activity
HIN86_09490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIN86_09540	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HIN86_09590	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_09605	COG2207	Transcriptional regulator
HIN86_09615	COG2205	protein histidine kinase activity
HIN86_09620	COG0745	RESPONSE REGULATOR receiver
HIN86_09625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN86_09630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIN86_09810	COG3539	Fimbrial protein
HIN86_09835	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HIN86_09845	COG0753	catalase activity
HIN86_09860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIN86_09925	COG3433	isochorismatase activity
HIN86_09925	COG1535	isochorismatase
HIN86_09930	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_09935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HIN86_09940	COG4149	molybdate abc transporter
HIN86_09945	COG0725	ABC transporter, periplasmic molybdate-binding protein
HIN86_09955	COG4638	Rieske (2fe-2S)
HIN86_09960	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HIN86_09965	COG0543	2 iron, 2 sulfur cluster binding
HIN86_09965	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN86_09980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN86_09990	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_10005	COG2207	Transcriptional regulator
HIN86_10010	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_10015	COG2610	gluconate transmembrane transporter activity
HIN86_10025	COG1309	transcriptional regulator
HIN86_10045	COG0583	DNA-binding transcription factor activity
HIN86_10060	COG2031	fatty acid transporter
HIN86_10065	COG0183	Belongs to the thiolase family
HIN86_10070	COG0583	DNA-binding transcription factor activity
HIN86_10075	COG0583	DNA-binding transcription factor activity
HIN86_10090	COG1027	Aspartate ammonia-lyase
HIN86_10100	COG0477	Major facilitator Superfamily
HIN86_10120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN86_10125	COG4521	taurine ABC transporter
HIN86_10140	COG2188	Transcriptional regulator
HIN86_10150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HIN86_10155	COG1733	regulation of RNA biosynthetic process
HIN86_10160	COG2207	Transcriptional regulator
HIN86_10160	COG3708	Transcriptional regulator
HIN86_10175	COG0730	response to heat
HIN86_10185	COG3453	Protein conserved in bacteria
HIN86_10185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN86_10195	COG3781	membrane
HIN86_10200	COG1063	alcohol dehydrogenase
HIN86_10210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIN86_10215	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIN86_10220	COG0022	dehydrogenase e1 component
HIN86_10225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HIN86_10230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HIN86_10245	COG3706	GGDEF domain
HIN86_10260	COG0133	tryptophan synthase activity
HIN86_10270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HIN86_10305	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HIN86_10330	COG2226	methyltransferase
HIN86_10385	COG0842	Transport permease protein
HIN86_10390	COG0842	Transport permease protein
HIN86_10395	COG1131	(ABC) transporter
HIN86_10410	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIN86_10415	COG4773	Receptor
HIN86_10435	COG0730	response to heat
HIN86_10440	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HIN86_10455	COG0406	alpha-ribazole phosphatase activity
HIN86_10460	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HIN86_10505	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HIN86_10515	COG4264	IucA IucC family
HIN86_10520	COG4264	IucA IucC family
HIN86_10525	COG2814	Major facilitator Superfamily
HIN86_10540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HIN86_10555	COG1960	acyl-CoA dehydrogenase activity
HIN86_10560	COG1960	acyl-CoA dehydrogenase activity
HIN86_10565	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIN86_10570	COG2207	Transcriptional regulator
HIN86_10575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HIN86_10580	COG0776	regulation of translation
HIN86_10605	COG0822	iron-sulfur transferase activity
HIN86_10610	COG0316	Belongs to the HesB IscA family
HIN86_10640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HIN86_10660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HIN86_10665	COG0702	epimerase
HIN86_10700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIN86_10705	COG0601	transmembrane transport
HIN86_10710	COG0339	signal peptide processing
HIN86_10755	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HIN86_10955	COG5377	YqaJ viral recombinase family
HIN86_10965	COG0210	DNA helicase
HIN86_11000	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HIN86_11030	COG0776	regulation of translation
HIN86_11095	COG0084	hydrolase, TatD family'
HIN86_11115	COG1663	tetraacyldisaccharide 4'-kinase activity
HIN86_11120	COG1132	(ABC) transporter
HIN86_11130	COG0811	peptide transport
HIN86_11135	COG1475	DNA binding
HIN86_11140	COG1192	Involved in chromosome partitioning
HIN86_11150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HIN86_11165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HIN86_11170	COG0191	fructose-bisphosphate aldolase activity
HIN86_11190	COG0424	maF-like protein
HIN86_11195	COG2850	peptidyl-arginine hydroxylation
HIN86_11205	COG0640	Transcriptional regulator
HIN86_11215	COG3619	membrane
HIN86_11220	COG3122	Protein conserved in bacteria
HIN86_11225	COG1132	(ABC) transporter
HIN86_11245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HIN86_11250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HIN86_11260	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HIN86_11260	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HIN86_11260	COG0506	proline dehydrogenase activity
HIN86_11265	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HIN86_11280	COG3698	Phosphodiester glycosidase
HIN86_11290	COG2353	YceI-like domain
HIN86_11300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HIN86_11370	COG3539	Fimbrial protein
HIN86_11375	COG3121	Chaperone
HIN86_11400	COG0697	spore germination
HIN86_11410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HIN86_11420	COG0583	DNA-binding transcription factor activity
HIN86_11440	COG1309	transcriptional regulator
HIN86_11455	COG1522	sequence-specific DNA binding
HIN86_11465	COG1126	abc transporter atp-binding protein
HIN86_11470	COG0765	amino acid transport
HIN86_11475	COG0765	amino acid transport
HIN86_11505	COG1464	Belongs to the NlpA lipoprotein family
HIN86_11520	COG2011	ABC-type metal ion transport system permease component
HIN86_11525	COG0012	GTP binding
HIN86_11550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HIN86_11590	COG0386	Belongs to the glutathione peroxidase family
HIN86_11600	COG0436	Aminotransferase
HIN86_11640	COG3634	alkyl hydroperoxide reductase activity
HIN86_11655	COG0583	DNA-binding transcription factor activity
HIN86_11660	COG0798	PFAM Bile acid sodium symporter
HIN86_11665	COG0640	Transcriptional regulator
HIN86_11680	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HIN86_11690	COG0583	DNA-binding transcription factor activity
HIN86_11700	COG1953	Uracil, thiamine, allantoin
HIN86_11720	COG2175	clavaminate synthase activity
HIN86_11725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN86_11730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HIN86_11735	COG4521	taurine ABC transporter
HIN86_11745	COG0477	Major facilitator Superfamily
HIN86_11765	COG1271	oxidase subunit
HIN86_11770	COG1294	oxidase, subunit
HIN86_11780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN86_11800	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HIN86_11820	COG3052	prosthetic group binding
HIN86_11825	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HIN86_11835	COG0583	DNA-binding transcription factor activity
HIN86_11845	COG2814	Major facilitator Superfamily
HIN86_11865	COG1346	cytolysis
HIN86_11875	COG0583	DNA-binding transcription factor activity
HIN86_11880	COG0625	glutathione transferase activity
HIN86_11885	COG0625	glutathione transferase activity
HIN86_11890	COG0583	DNA-binding transcription factor activity
HIN86_11905	COG1045	serine acetyltransferase
HIN86_11910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HIN86_11915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HIN86_11920	COG1280	lysine exporter protein (LysE YggA)
HIN86_11930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIN86_11935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIN86_11940	COG1126	abc transporter atp-binding protein
HIN86_11945	COG0765	amino acid transport
HIN86_11950	COG0765	amino acid transport
HIN86_11970	COG2205	protein histidine kinase activity
HIN86_11970	COG0784	Response regulator, receiver
HIN86_11990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIN86_12010	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_12060	COG0583	DNA-binding transcription factor activity
HIN86_12080	COG0318	PFAM AMP-dependent synthetase and ligase
HIN86_12085	COG1309	transcriptional regulator
HIN86_12090	COG1960	acyl-CoA dehydrogenase activity
HIN86_12095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HIN86_12100	COG1024	Enoyl-CoA hydratase
HIN86_12105	COG4770	biotin carboxylase activity
HIN86_12115	COG0583	DNA-binding transcription factor activity
HIN86_12130	COG1960	acyl-CoA dehydrogenase activity
HIN86_12140	COG2814	Major facilitator Superfamily
HIN86_12150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HIN86_12155	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HIN86_12160	COG2814	Major facilitator Superfamily
HIN86_12165	COG1960	acyl-CoA dehydrogenase activity
HIN86_12170	COG1024	Enoyl-CoA hydratase
HIN86_12175	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_12180	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIN86_12185	COG0183	Belongs to the thiolase family
HIN86_12195	COG2814	Major facilitator Superfamily
HIN86_12205	COG1024	Enoyl-CoA hydratase
HIN86_12220	COG1960	acyl-CoA dehydrogenase activity
HIN86_12225	COG2814	Major facilitator Superfamily
HIN86_12230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HIN86_12235	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HIN86_12250	COG3842	ATPase activity
HIN86_12255	COG1840	ABC-type Fe3 transport system, periplasmic component
HIN86_12265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN86_12270	COG1414	Transcriptional regulator
HIN86_12280	COG0583	DNA-binding transcription factor activity
HIN86_12285	COG3038	cytochrome b561
HIN86_12290	COG0753	catalase activity
HIN86_12295	COG2271	Major facilitator Superfamily
HIN86_12300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HIN86_12305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HIN86_12320	COG2207	Transcriptional regulator
HIN86_12360	COG3210	domain, Protein
HIN86_12365	COG2831	hemolysin activation secretion protein
HIN86_12370	COG0038	chloride channel
HIN86_12375	COG4770	biotin carboxylase activity
HIN86_12395	COG1914	H( )-stimulated, divalent metal cation uptake system
HIN86_12400	COG0583	DNA-binding transcription factor activity
HIN86_12430	COG3209	COG3209 Rhs family protein
HIN86_12435	COG3501	Rhs element vgr protein
HIN86_12460	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIN86_12480	COG2814	Major facilitator Superfamily
HIN86_12490	COG1560	Kdo2-lipid A biosynthetic process
HIN86_12500	COG5006	permease, DMT superfamily
HIN86_12505	COG1522	sequence-specific DNA binding
HIN86_12520	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HIN86_12530	COG4122	O-methyltransferase activity
HIN86_12560	COG1538	Outer membrane efflux protein
HIN86_12570	COG1137	ATPase activity
HIN86_12575	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HIN86_12585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HIN86_12635	COG2814	Major facilitator Superfamily
HIN86_12670	COG1278	Cold shock
HIN86_12675	COG1280	lysine exporter protein (LysE YggA)
HIN86_12710	COG1570	exodeoxyribonuclease VII activity
HIN86_12760	COG0583	DNA-binding transcription factor activity
HIN86_12765	COG4638	Rieske (2fe-2S)
HIN86_12770	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HIN86_12775	COG0633	Ferredoxin
HIN86_12775	COG0543	2 iron, 2 sulfur cluster binding
HIN86_12780	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_12785	COG3135	benzoate transporter
HIN86_12790	COG2814	Major facilitator Superfamily
HIN86_12805	COG1643	Atp-dependent helicase
HIN86_12810	COG0450	alkyl hydroperoxide reductase
HIN86_12820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HIN86_12830	COG3634	alkyl hydroperoxide reductase activity
HIN86_12850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HIN86_12855	COG0625	glutathione transferase activity
HIN86_12865	COG2885	chlorophyll binding
HIN86_12900	COG0542	response to heat
HIN86_12915	COG1765	OsmC-like protein
HIN86_12925	COG0667	Aldo Keto reductase
HIN86_12940	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HIN86_12950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HIN86_12960	COG0527	aspartate kinase activity
HIN86_12970	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HIN86_12980	COG3038	cytochrome b561
HIN86_12985	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HIN86_12990	COG2252	PERMEase
HIN86_13000	COG2072	flavoprotein involved in K transport
HIN86_13015	COG1741	Belongs to the pirin family
HIN86_13020	COG1309	transcriptional regulator
HIN86_13030	COG0300	oxidoreductase activity
HIN86_13035	COG2072	flavoprotein involved in K transport
HIN86_13040	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HIN86_13085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN86_13100	COG2814	Major facilitator Superfamily
HIN86_13105	COG1024	Enoyl-CoA hydratase
HIN86_13110	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_13120	COG1960	acyl-CoA dehydrogenase activity
HIN86_13145	COG2186	Transcriptional regulator
HIN86_13150	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_13160	COG4948	Mandelate Racemase Muconate Lactonizing
HIN86_13165	COG2271	Major facilitator Superfamily
HIN86_13170	COG2721	sulfolactate sulfo-lyase activity
HIN86_13175	COG0697	spore germination
HIN86_13190	COG1113	amino acid transport
HIN86_13210	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_13230	COG0531	amino acid
HIN86_13240	COG1113	amino acid transport
HIN86_13285	COG3209	COG3209 Rhs family protein
HIN86_13290	COG3501	Rhs element vgr protein
HIN86_13310	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIN86_13310	COG1902	pentaerythritol trinitrate reductase activity
HIN86_13320	COG5001	Diguanylate cyclase
HIN86_13320	COG2203	Gaf domain
HIN86_13320	COG3706	GGDEF domain
HIN86_13320	COG4251	negative regulation of phosphorylation
HIN86_13330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIN86_13365	COG4172	Belongs to the ABC transporter superfamily
HIN86_13370	COG4239	(ABC) transporter, permease
HIN86_13375	COG4174	ABC transporter (Permease)
HIN86_13380	COG4166	transmembrane transport
HIN86_13385	COG1388	LysM domain
HIN86_13385	COG0741	lytic transglycosylase activity
HIN86_13385	COG1388	LysM domain
HIN86_13385	COG0741	lytic transglycosylase activity
HIN86_13390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIN86_13430	COG0583	DNA-binding transcription factor activity
HIN86_13435	COG1279	arginine transmembrane transporter activity
HIN86_13455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN86_13460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN86_13465	COG0006	proline dipeptidase activity
HIN86_13600	COG1598	PFAM Uncharacterised protein family UPF0150
HIN86_13795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIN86_13860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HIN86_13895	COG3384	dioxygenase
HIN86_13905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HIN86_13910	COG2878	Part of a membrane complex involved in electron transport
HIN86_13915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HIN86_13940	COG0768	penicillin binding
HIN86_13945	COG0742	ribosomal rna small subunit methyltransferase
HIN86_13960	COG0830	nickel cation binding
HIN86_13970	COG0804	urea catabolic process
HIN86_14010	COG1253	flavin adenine dinucleotide binding
HIN86_14015	COG2851	Citrate transporter
HIN86_14065	COG1773	rubredoxin
HIN86_14070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN86_14080	COG0583	DNA-binding transcription factor activity
HIN86_14110	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HIN86_14115	COG4181	ATPase activity
HIN86_14160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HIN86_14180	COG0306	phosphate transporter
HIN86_14195	COG3958	Transketolase
HIN86_14200	COG3959	Transketolase, thiamine diphosphate binding domain
HIN86_14205	COG2271	Major facilitator Superfamily
HIN86_14210	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_14215	COG0583	DNA-binding transcription factor activity
HIN86_14230	COG2223	nitrite transmembrane transporter activity
HIN86_14235	COG2207	Transcriptional regulator
HIN86_14240	COG2066	Belongs to the glutaminase family
HIN86_14245	COG0242	peptide deformylase activity
HIN86_14250	COG0477	Major facilitator Superfamily
HIN86_14260	COG0028	Belongs to the TPP enzyme family
HIN86_14275	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_14280	COG2267	carboxylic ester hydrolase activity
HIN86_14290	COG2271	Major facilitator Superfamily
HIN86_14305	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_14325	COG1414	Transcriptional regulator
HIN86_14340	COG1024	Enoyl-CoA hydratase
HIN86_14350	COG1215	transferase activity, transferring glycosyl groups
HIN86_14355	COG1649	PFAM Uncharacterised BCR, COG1649
HIN86_14355	COG0726	polysaccharide deacetylase
HIN86_14365	COG4681	YaeQ
HIN86_14375	COG0523	cobalamin synthesis protein
HIN86_14385	COG1607	acyl-coa hydrolase
HIN86_14395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HIN86_14400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HIN86_14405	COG1309	transcriptional regulator
HIN86_14435	COG0531	amino acid
HIN86_14460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN86_14465	COG0477	Major facilitator Superfamily
HIN86_14530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HIN86_14600	COG0592	DNA-directed DNA polymerase activity
HIN86_14770	COG3755	Protein conserved in bacteria
HIN86_14855	COG1484	DNA-dependent DNA replication
HIN86_14935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIN86_15005	COG0405	Gamma-glutamyltransferase
HIN86_15010	COG2814	Major facilitator Superfamily
HIN86_15020	COG2050	protein possibly involved in aromatic compounds catabolism
HIN86_15035	COG1090	epimerase
HIN86_15055	COG0420	3'-5' exonuclease activity
HIN86_15080	COG0735	belongs to the Fur family
HIN86_15085	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIN86_15105	COG0121	glutamine amidotransferase
HIN86_15120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIN86_15130	COG0210	DNA helicase
HIN86_15135	COG2885	chlorophyll binding
HIN86_15140	COG0204	Acyl-transferase
HIN86_15155	COG2894	cell division
HIN86_15170	COG1280	lysine exporter protein (LysE YggA)
HIN86_15175	COG1674	ftsk spoiiie
HIN86_15175	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HIN86_15180	COG0492	ferredoxin-NADP+ reductase activity
HIN86_15185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HIN86_15195	COG0456	acetyltransferase
HIN86_15255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIN86_15255	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HIN86_15275	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_15295	COG0473	3-isopropylmalate dehydrogenase activity
HIN86_15300	COG0583	DNA-binding transcription factor activity
HIN86_15320	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIN86_15330	COG0582	viral genome integration into host DNA
HIN86_15645	COG0564	pseudouridine synthase activity
HIN86_15655	COG0358	DNA primase activity
HIN86_15670	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HIN86_15700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIN86_15730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HIN86_15740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HIN86_15740	COG0352	thiamine-phosphate diphosphorylase activity
HIN86_15740	COG0351	phosphomethylpyrimidine kinase
HIN86_15745	COG1652	LysM domain
HIN86_15770	COG1399	metal-binding, possibly nucleic acid-binding protein
HIN86_15775	COG3101	peptidyl-lysine hydroxylation
HIN86_15780	COG0009	L-threonylcarbamoyladenylate synthase
HIN86_15785	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HIN86_15790	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HIN86_15805	COG4106	trans-aconitate 2-methyltransferase activity
HIN86_15820	COG2226	methyltransferase
HIN86_15820	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIN86_15820	COG0596	Alpha beta hydrolase
HIN86_15825	COG1877	trehalose-phosphatase activity
HIN86_15830	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HIN86_15835	COG2223	nitrite transmembrane transporter activity
HIN86_15855	COG1196	nuclear chromosome segregation
HIN86_15865	COG0730	response to heat
HIN86_15880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIN86_15890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIN86_15940	COG0489	protein tyrosine kinase activity
HIN86_15950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIN86_15950	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIN86_15980	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HIN86_15985	COG2081	HI0933 family
HIN86_15995	COG0668	transmembrane transport
HIN86_16015	COG0583	DNA-binding transcription factor activity
HIN86_16035	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIN86_16040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HIN86_16070	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HIN86_16105	COG2205	protein histidine kinase activity
HIN86_16110	COG0745	RESPONSE REGULATOR receiver
HIN86_16130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIN86_16145	COG0535	radical SAM domain protein
HIN86_16240	COG1309	transcriptional regulator
HIN86_16245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN86_16270	COG1473	amidohydrolase
HIN86_16280	COG0583	DNA-binding transcription factor activity
HIN86_16295	COG0583	DNA-binding transcription factor activity
HIN86_16300	COG1053	succinate dehydrogenase
HIN86_16315	COG1309	transcriptional regulator
HIN86_16320	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HIN86_16325	COG2814	Major facilitator Superfamily
HIN86_16330	COG1960	acyl-CoA dehydrogenase activity
HIN86_16335	COG0583	DNA-binding transcription factor activity
HIN86_16340	COG1063	alcohol dehydrogenase
HIN86_16370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HIN86_16375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HIN86_16380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HIN86_16400	COG2132	Multicopper oxidase
HIN86_16410	COG0561	phosphatase activity
HIN86_16415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HIN86_16440	COG1214	PFAM Peptidase M22, glycoprotease
HIN86_16500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HIN86_16505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HIN86_16510	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HIN86_16570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIN86_16580	COG1846	Transcriptional regulator
HIN86_16585	COG1764	response to oxidative stress
HIN86_16625	COG0037	tRNA processing
HIN86_16635	COG0248	Ppx GppA phosphatase
HIN86_16665	COG0072	phenylalanine-tRNA ligase activity
HIN86_16705	COG1238	metal cluster binding
HIN86_16710	COG0625	glutathione transferase activity
HIN86_16725	COG0318	PFAM AMP-dependent synthetase and ligase
HIN86_16730	COG3028	Belongs to the UPF0307 family
HIN86_16735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIN86_16755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HIN86_16760	COG0617	tRNA 3'-terminal CCA addition
HIN86_16765	COG1555	photosystem II stabilization
HIN86_16770	COG3956	TIGRFAM MazG family protein
HIN86_16780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIN86_16800	COG5002	protein histidine kinase activity
HIN86_16800	COG2205	protein histidine kinase activity
HIN86_16800	COG0784	Response regulator, receiver
HIN86_16805	COG1024	Enoyl-CoA hydratase
HIN86_16810	COG2084	Dehydrogenase
HIN86_16815	COG3622	Belongs to the hyi family
HIN86_16845	COG0697	spore germination
HIN86_16855	COG2814	Major facilitator Superfamily
HIN86_16865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HIN86_16880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIN86_16890	COG0583	DNA-binding transcription factor activity
HIN86_16900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HIN86_16915	COG0084	hydrolase, TatD family'
HIN86_16930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HIN86_16960	COG0440	acetolactate synthase activity
HIN86_16965	COG0028	Belongs to the TPP enzyme family
HIN86_16990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN86_16995	COG1136	(ABC) transporter
HIN86_16995	COG0577	efflux transmembrane transporter activity
HIN86_17000	COG1538	Outer membrane efflux protein
HIN86_17015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HIN86_17020	COG1162	GTPase activity
HIN86_17030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HIN86_17070	COG1426	Protein conserved in bacteria
HIN86_17105	COG0793	Belongs to the peptidase S41A family
HIN86_17120	COG2267	carboxylic ester hydrolase activity
HIN86_17130	COG1012	belongs to the aldehyde dehydrogenase family
HIN86_17135	COG3265	gluconokinase activity
HIN86_17145	COG0800	Aldolase
HIN86_17155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HIN86_17160	COG0280	phosphate acetyltransferase
HIN86_17160	COG0857	belongs to the CobB CobQ family
HIN86_17165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HIN86_17165	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HIN86_17185	COG0740	serine-type endopeptidase activity
HIN86_17195	COG4774	siderophore transport
HIN86_17205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HIN86_17215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIN86_17215	COG2813	Specifically methylates the guanine in position
HIN86_17315	COG0788	formyltetrahydrofolate deformylase activity
HIN86_17340	COG4651	solute:proton antiporter activity
HIN86_17340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HIN86_17360	COG0724	RNA recognition motif
HIN86_17365	COG0210	DNA helicase
HIN86_17390	COG1733	regulation of RNA biosynthetic process
HIN86_17400	COG2900	Belongs to the SlyX family
HIN86_17415	COG1280	lysine exporter protein (LysE YggA)
HIN86_17420	COG1560	Kdo2-lipid A biosynthetic process
HIN86_17430	COG1301	dicarboxylic acid transport
HIN86_17485	COG0473	3-isopropylmalate dehydrogenase activity
HIN86_17540	COG0583	DNA-binding transcription factor activity
HIN86_17550	COG0625	glutathione transferase activity
HIN86_17555	COG2378	regulation of single-species biofilm formation
HIN86_17560	COG0546	phosphoglycolate phosphatase activity
HIN86_17575	COG1530	ribonuclease E activity
HIN86_17580	COG0318	PFAM AMP-dependent synthetase and ligase
HIN86_17595	COG0583	DNA-binding transcription factor activity
HIN86_17600	COG4221	oxidoreductase activity
HIN86_17605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HIN86_17615	COG0534	Mate efflux family protein
HIN86_17630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HIN86_17665	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HIN86_17670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN86_17685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HIN86_17695	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HIN86_17695	COG0644	oxidoreductase
HIN86_17705	COG0425	Belongs to the sulfur carrier protein TusA family
HIN86_17710	COG4535	Mg2 and Co2 transporter CorC
HIN86_17720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIN86_17740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HIN86_17745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HIN86_17745	COG0475	glutathione-regulated potassium exporter activity
HIN86_17760	COG0484	heat shock protein binding
HIN86_17765	COG0789	Transcriptional regulator
HIN86_17770	COG0598	Magnesium transport protein CorA
HIN86_17790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN86_17795	COG1074	ATP-dependent DNA helicase activity
HIN86_17800	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HIN86_17820	COG2226	methyltransferase
HIN86_17835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN86_17840	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HIN86_17855	COG2111	Na H antiporter
HIN86_17855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HIN86_17860	COG1006	Multisubunit Na H antiporter MnhC subunit
HIN86_17865	COG0651	ATP synthesis coupled electron transport
HIN86_17875	COG2212	antiporter activity
HIN86_17895	COG0195	Participates in both transcription termination and antitermination
HIN86_17945	COG0237	dephospho-CoA kinase activity
HIN86_17955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIN86_17970	COG0497	DNA recombination
HIN86_17980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HIN86_18010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HIN86_18010	COG2169	Transcriptional regulator
HIN86_18015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HIN86_18070	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HIN86_18085	COG0326	Molecular chaperone. Has ATPase activity
HIN86_18100	COG2056	Na+-H+ antiporter family
HIN86_18105	COG0596	Alpha beta hydrolase
HIN86_18200	COG0546	phosphoglycolate phosphatase activity
HIN86_18205	COG1716	ATPase activity
HIN86_18250	COG0181	hydroxymethylbilane synthase activity
HIN86_18260	COG3275	phosphorelay sensor kinase activity
HIN86_18280	COG1538	Outer membrane efflux protein
HIN86_18285	COG0697	spore germination
HIN86_18310	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HIN86_18315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HIN86_18320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIN86_18325	COG0772	Belongs to the SEDS family
HIN86_18350	COG4974	Belongs to the 'phage' integrase family
HIN86_18355	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIN86_18365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HIN86_18375	COG2197	response regulator
HIN86_18390	COG0793	Belongs to the peptidase S41A family
HIN86_18395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HIN86_18400	COG0795	lipopolysaccharide-transporting ATPase activity
HIN86_18440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIN86_18440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIN86_18450	COG0004	ammonium transporteR
HIN86_18455	COG0347	Belongs to the P(II) protein family
HIN86_18465	COG0606	chelatase, subunit chli
HIN86_18475	COG0659	secondary active sulfate transmembrane transporter activity
HIN86_18500	COG0789	Transcriptional regulator
HIN86_18560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HIN86_18585	COG0789	Transcriptional regulator
HIN86_18590	COG0589	response to stress
HIN86_18600	COG0640	Transcriptional regulator
HIN86_18610	COG0798	PFAM Bile acid sodium symporter
HIN86_18615	COG0431	NADPH-dependent FMN reductase
HIN86_18620	COG0492	ferredoxin-NADP+ reductase activity
HIN86_18625	COG2072	flavoprotein involved in K transport
HIN86_18655	COG0606	chelatase, subunit chli
HIN86_18660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN86_18670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN86_18685	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HIN86_18700	COG0318	PFAM AMP-dependent synthetase and ligase
HIN86_18710	COG0477	Major facilitator Superfamily
HIN86_18715	COG2860	membrane
HIN86_18725	COG1253	flavin adenine dinucleotide binding
HIN86_18735	COG0477	Major facilitator Superfamily
HIN86_18745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HIN86_18780	COG0655	NAD(P)H dehydrogenase (quinone) activity
HIN86_18795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HIN86_18830	COG1309	transcriptional regulator
HIN86_18865	COG0758	DNA mediated transformation
HIN86_18875	COG0697	spore germination
HIN86_18880	COG1309	transcriptional regulator
HIN86_18895	COG0386	Belongs to the glutathione peroxidase family
HIN86_18960	COG1121	(ABC) transporter
HIN86_18965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HIN86_18970	COG1280	lysine exporter protein (LysE YggA)
HIN86_18975	COG2837	iron assimilation
HIN86_18980	COG0281	malic enzyme
HIN86_19025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HIN86_19025	COG0519	Catalyzes the synthesis of GMP from XMP
HIN86_19030	COG4399	Belongs to the UPF0754 family
HIN86_19035	COG2259	Doxx family
HIN86_19040	COG0586	Pfam SNARE associated Golgi protein
HIN86_19055	COG1192	Involved in chromosome partitioning
HIN86_19065	COG0271	Belongs to the BolA IbaG family
HIN86_19105	COG3321	synthase
HIN86_19105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HIN86_19105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HIN86_19105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HIN86_19110	COG1960	acyl-CoA dehydrogenase activity
HIN86_19120	COG2197	response regulator
HIN86_19130	COG3916	Acyl-homoserine-lactone synthase
HIN86_19135	COG0477	Major facilitator Superfamily
HIN86_19140	COG1024	Enoyl-CoA hydratase
HIN86_19145	COG1024	Enoyl-CoA hydratase
HIN86_19150	COG1960	acyl-CoA dehydrogenase activity
HIN86_19155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIN86_19175	COG1113	amino acid transport
HIN86_19180	COG1113	amino acid transport
HIN86_19185	COG0251	oxidation-reduction process
HIN86_19225	COG0564	pseudouridine synthase activity
HIN86_19280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HIN86_19295	COG1802	Transcriptional regulator
HIN86_19305	COG1448	Aminotransferase
HIN86_19310	COG0277	FAD linked oxidase domain protein
HIN86_19320	COG2186	Transcriptional regulator
HIN86_19330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIN86_19340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIN86_19355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HIN86_19360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HIN86_19370	COG0438	transferase activity, transferring glycosyl groups
HIN86_19375	COG0438	transferase activity, transferring glycosyl groups
HIN86_19380	COG1216	Glycosyl transferase, family 2
HIN86_19380	COG0463	Glycosyl transferase, family 2
HIN86_19400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HIN86_19410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HIN86_19440	COG0728	peptidoglycan biosynthetic process
HIN86_19445	COG3023	N-Acetylmuramoyl-L-alanine amidase
HIN86_19500	COG0546	phosphoglycolate phosphatase activity
HIN86_19505	COG1028	Short-chain dehydrogenase reductase Sdr
HIN86_19525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN86_19530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN86_19535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN86_19540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN86_19545	COG1116	anion transmembrane transporter activity
HIN86_19550	COG1309	transcriptional regulator
HIN86_19555	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HIN86_19565	COG0196	riboflavin kinase activity
HIN86_19570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HIN86_19580	COG1047	Peptidyl-prolyl cis-trans
HIN86_19620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HIN86_19675	COG2951	lytic endotransglycosylase activity
HIN86_19680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HIN86_19695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HIN86_19705	COG0671	phosphoesterase, PA-phosphatase related
HIN86_19710	COG0861	Integral membrane protein TerC family
HIN86_19720	COG0754	glutathionylspermidine amidase activity
HIN86_19730	COG0402	S-adenosylhomocysteine deaminase activity
HIN86_19765	COG1660	Displays ATPase and GTPase activities
HIN86_19810	COG1230	cation diffusion facilitator family transporter
HIN86_19825	COG0706	membrane insertase activity
HIN86_19885	COG1192	Involved in chromosome partitioning
HIN86_19935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HIN86_19955	COG3451	type IV secretory pathway VirB4
HIN86_20040	COG3173	Aminoglycoside phosphotransferase
HIN86_20050	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN86_20055	COG3657	addiction module killer protein
HIN86_20075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs