locus-tag	class	description
HIN88_00010	COG0592	DNA-directed DNA polymerase activity
HIN88_00020	COG0187	DNA topoisomerase II activity
HIN88_00030	COG0586	Pfam SNARE associated Golgi protein
HIN88_00035	COG0488	(ABC) transporter
HIN88_00060	COG0596	Alpha beta hydrolase
HIN88_00065	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HIN88_00070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HIN88_00110	COG0733	neurotransmitter:sodium symporter activity
HIN88_00150	COG2233	PERMEase
HIN88_00165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_00200	COG2814	Major facilitator Superfamily
HIN88_00205	COG0656	L-ascorbic acid biosynthetic process
HIN88_00210	COG0583	DNA-binding transcription factor activity
HIN88_00225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN88_00230	COG1064	alcohol dehydrogenase
HIN88_00235	COG2818	Glycosylase
HIN88_00250	COG1194	a g-specific adenine glycosylase
HIN88_00270	COG2983	Belongs to the UPF0260 family
HIN88_00275	COG2133	pyrroloquinoline quinone binding
HIN88_00280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HIN88_00285	COG2116	formate transmembrane transporter activity
HIN88_00305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN88_00310	COG1335	isochorismatase
HIN88_00315	COG0385	Bile acid
HIN88_00320	COG1683	Conserved Protein
HIN88_00340	COG0625	glutathione transferase activity
HIN88_00350	COG1113	amino acid transport
HIN88_00360	COG0523	cobalamin synthesis protein
HIN88_00370	COG2188	Transcriptional regulator
HIN88_00400	COG0010	Belongs to the arginase family
HIN88_00415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HIN88_00430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HIN88_00440	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HIN88_00445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HIN88_00540	COG0534	Mate efflux family protein
HIN88_00545	COG0436	Aminotransferase
HIN88_00550	COG2733	membrane
HIN88_00565	COG2918	glutathione biosynthetic process
HIN88_00575	COG3501	Rhs element vgr protein
HIN88_00625	COG3150	esterase
HIN88_00635	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HIN88_00645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN88_00655	COG2233	PERMEase
HIN88_00660	COG2351	hydroxyisourate hydrolase activity
HIN88_00710	COG1393	Belongs to the ArsC family
HIN88_00715	COG0708	Exodeoxyribonuclease III
HIN88_00735	COG0189	ligase activity
HIN88_00755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HIN88_00765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HIN88_00780	COG4942	peptidase
HIN88_00790	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIN88_00800	COG2119	membrane
HIN88_00805	COG4774	siderophore transport
HIN88_00810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_00810	COG0426	domain, Protein
HIN88_00835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HIN88_00855	COG1902	pentaerythritol trinitrate reductase activity
HIN88_00860	COG1519	Transferase
HIN88_00865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HIN88_00870	COG0668	transmembrane transport
HIN88_00880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIN88_00885	COG1335	isochorismatase
HIN88_00890	COG1522	sequence-specific DNA binding
HIN88_00915	COG2198	Histidine kinase
HIN88_00915	COG0784	Response regulator, receiver
HIN88_00915	COG2205	protein histidine kinase activity
HIN88_00920	COG3162	membrane
HIN88_00925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HIN88_00935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HIN88_00945	COG3706	GGDEF domain
HIN88_00955	COG1309	transcriptional regulator
HIN88_00975	COG0351	phosphomethylpyrimidine kinase
HIN88_00975	COG0352	thiamine-phosphate diphosphorylase activity
HIN88_00975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HIN88_00985	COG2814	Major facilitator Superfamily
HIN88_01000	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HIN88_01010	COG1113	amino acid transport
HIN88_01020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HIN88_01025	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_01035	COG1335	isochorismatase
HIN88_01105	COG2814	Major facilitator Superfamily
HIN88_01130	COG0667	Aldo Keto reductase
HIN88_01165	COG1733	regulation of RNA biosynthetic process
HIN88_01170	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIN88_01230	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HIN88_01275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HIN88_01305	COG0427	acetyl-CoA hydrolase
HIN88_01320	COG0745	RESPONSE REGULATOR receiver
HIN88_01330	COG0659	secondary active sulfate transmembrane transporter activity
HIN88_01335	COG4221	oxidoreductase activity
HIN88_01345	COG0488	(ABC) transporter
HIN88_01410	COG0833	amino acid
HIN88_01455	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HIN88_01460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HIN88_01475	COG2226	methyltransferase
HIN88_01525	COG0070	glutamate synthase
HIN88_01525	COG0067	glutamate synthase
HIN88_01525	COG0069	glutamate synthase activity
HIN88_01530	COG0493	'glutamate synthase
HIN88_01540	COG1704	LemA family
HIN88_01545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HIN88_01560	COG3307	-O-antigen
HIN88_01580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIN88_01595	COG0194	GDP metabolic process
HIN88_01645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HIN88_01665	COG5380	lipid catabolic process
HIN88_01670	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HIN88_01695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HIN88_01700	COG0277	FAD linked oxidase domain protein
HIN88_01710	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HIN88_01715	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIN88_01730	COG1289	transmembrane transporter activity
HIN88_01740	COG0628	permease
HIN88_01745	COG1192	Involved in chromosome partitioning
HIN88_01775	COG0833	amino acid
HIN88_01780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HIN88_01785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HIN88_01795	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_01835	COG0583	DNA-binding transcription factor activity
HIN88_01880	COG0517	IMP dehydrogenase activity
HIN88_01885	COG1983	PspC domain protein
HIN88_01895	COG1960	acyl-CoA dehydrogenase activity
HIN88_01910	COG0408	coproporphyrinogen oxidase activity
HIN88_01930	COG0513	Belongs to the DEAD box helicase family
HIN88_01940	COG1127	ABC transporter
HIN88_01945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HIN88_01955	COG2854	intermembrane phospholipid transfer
HIN88_01965	COG0598	Magnesium transport protein CorA
HIN88_01975	COG0494	nUDIX hydrolase
HIN88_01980	COG1040	competence protein
HIN88_01985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HIN88_02005	COG1946	Acyl-CoA thioesterase
HIN88_02010	COG1301	dicarboxylic acid transport
HIN88_02025	COG1959	2 iron, 2 sulfur cluster binding
HIN88_02030	COG1017	nitric oxide dioxygenase activity
HIN88_02030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN88_02040	COG0433	COG0433 Predicted ATPase
HIN88_02045	COG0626	cystathionine gamma-synthase activity
HIN88_02200	COG1960	acyl-CoA dehydrogenase activity
HIN88_02205	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HIN88_02235	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HIN88_02240	COG0339	signal peptide processing
HIN88_02245	COG0557	exoribonuclease II activity
HIN88_02290	COG0179	Fumarylacetoacetate (FAA) hydrolase
HIN88_02295	COG2169	Transcriptional regulator
HIN88_02300	COG0697	spore germination
HIN88_02305	COG1295	ribonuclease BN
HIN88_02340	COG1702	phosphate starvation-inducible protein PhoH
HIN88_02350	COG1196	nuclear chromosome segregation
HIN88_02350	COG0739	heme binding
HIN88_02350	COG0741	lytic transglycosylase activity
HIN88_02380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HIN88_02385	COG1183	phosphatidylcholine synthase activity
HIN88_02430	COG1960	acyl-CoA dehydrogenase activity
HIN88_02435	COG1309	transcriptional regulator
HIN88_02450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HIN88_02455	COG1960	acyl-CoA dehydrogenase activity
HIN88_02475	COG2969	positive regulation of protein catabolic process
HIN88_02485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HIN88_02500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HIN88_02505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HIN88_02525	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HIN88_02535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIN88_02540	COG1408	metallophosphoesterase
HIN88_02550	COG2199	diguanylate cyclase activity
HIN88_02610	COG1607	acyl-coa hydrolase
HIN88_02640	COG2350	Protein conserved in bacteria
HIN88_02650	COG0613	PHP domain protein
HIN88_02655	COG3781	membrane
HIN88_02665	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HIN88_02670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HIN88_02680	COG1862	Preprotein translocase
HIN88_02715	COG2205	protein histidine kinase activity
HIN88_02720	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HIN88_02735	COG0726	polysaccharide deacetylase
HIN88_02740	COG0438	transferase activity, transferring glycosyl groups
HIN88_02750	COG0438	transferase activity, transferring glycosyl groups
HIN88_02765	COG1442	glycosyl transferase family 8
HIN88_02820	COG1960	acyl-CoA dehydrogenase activity
HIN88_02825	COG1960	acyl-CoA dehydrogenase activity
HIN88_02835	COG2205	protein histidine kinase activity
HIN88_02840	COG0745	RESPONSE REGULATOR receiver
HIN88_02845	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HIN88_02865	COG2096	Adenosyltransferase
HIN88_02915	COG0285	dihydrofolate synthase activity
HIN88_02935	COG0450	alkyl hydroperoxide reductase
HIN88_02950	COG0477	Major facilitator Superfamily
HIN88_02955	COG1272	protein, Hemolysin III
HIN88_02985	COG0183	Belongs to the thiolase family
HIN88_02990	COG2207	Transcriptional regulator
HIN88_03010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN88_03030	COG0183	Belongs to the thiolase family
HIN88_03040	COG2885	chlorophyll binding
HIN88_03040	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HIN88_03050	COG1690	Belongs to the RtcB family
HIN88_03055	COG0833	amino acid
HIN88_03065	COG2233	PERMEase
HIN88_03095	COG2094	Belongs to the DNA glycosylase MPG family
HIN88_03100	COG4772	TonB-dependent receptor
HIN88_03105	COG1902	pentaerythritol trinitrate reductase activity
HIN88_03120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIN88_03125	COG0354	folic acid binding
HIN88_03135	COG3189	MarR family transcriptional regulator
HIN88_03140	COG2824	Alkylphosphonate utilization operon protein PhnA
HIN88_03145	COG3422	double-strand break repair
HIN88_03185	COG0840	transmembrane signaling receptor activity
HIN88_03200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HIN88_03215	COG5510	response to toxic substance
HIN88_03225	COG2832	Protein of unknown function (DUF454)
HIN88_03230	COG1376	ErfK ybiS ycfS ynhG family protein
HIN88_03270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HIN88_03280	COG1289	transmembrane transporter activity
HIN88_03285	COG2814	Major facilitator Superfamily
HIN88_03305	COG1115	amino acid carrier protein
HIN88_03310	COG1752	Esterase of the alpha-beta hydrolase superfamily
HIN88_03315	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HIN88_03320	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HIN88_03345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIN88_03355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HIN88_03360	COG1077	Cell shape determining protein MreB Mrl
HIN88_03365	COG1792	Involved in formation and maintenance of cell shape
HIN88_03370	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HIN88_03375	COG0424	maF-like protein
HIN88_03380	COG1530	ribonuclease E activity
HIN88_03390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN88_03400	COG0560	Phosphoserine phosphatase
HIN88_03410	COG2249	NAD(P)H dehydrogenase (quinone) activity
HIN88_03435	COG2207	Transcriptional regulator
HIN88_03455	COG1113	amino acid transport
HIN88_03460	COG2828	Protein conserved in bacteria
HIN88_03465	COG0142	geranyltranstransferase activity
HIN88_03470	COG2315	Protein conserved in bacteria
HIN88_03485	COG1752	Esterase of the alpha-beta hydrolase superfamily
HIN88_03505	COG2194	sulfuric ester hydrolase activity
HIN88_03510	COG0745	RESPONSE REGULATOR receiver
HIN88_03515	COG0642	Histidine kinase
HIN88_03525	COG0004	ammonium transporteR
HIN88_03530	COG0583	DNA-binding transcription factor activity
HIN88_03550	COG0525	valine-tRNA ligase activity
HIN88_03560	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_03570	COG0393	Putative heavy-metal-binding
HIN88_03575	COG0393	Putative heavy-metal-binding
HIN88_03580	COG1538	Outer membrane efflux protein
HIN88_03590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_03625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HIN88_03640	COG1648	precorrin-2 dehydrogenase activity
HIN88_03640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HIN88_03645	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HIN88_03650	COG1733	regulation of RNA biosynthetic process
HIN88_03660	COG0531	amino acid
HIN88_03675	COG0321	lipoyl(octanoyl) transferase activity
HIN88_03680	COG2921	Belongs to the UPF0250 family
HIN88_03715	COG2009	succinate dehydrogenase
HIN88_03720	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HIN88_03725	COG1053	succinate dehydrogenase
HIN88_03730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HIN88_03755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIN88_03775	COG2354	Protein conserved in bacteria
HIN88_03780	COG2321	neutral zinc metallopeptidase
HIN88_03830	COG2843	Capsule synthesis protein
HIN88_03845	COG0589	response to stress
HIN88_03865	COG0505	Belongs to the CarA family
HIN88_03890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HIN88_03895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HIN88_03945	COG0477	Major facilitator Superfamily
HIN88_03950	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HIN88_03965	COG1597	lipid kinase activity
HIN88_03970	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HIN88_03990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN88_03995	COG0584	glycerophosphoryl diester phosphodiesterase
HIN88_04015	COG0741	lytic transglycosylase activity
HIN88_04035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HIN88_04050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN88_04085	COG0778	Nitroreductase
HIN88_04090	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_04100	COG1929	Belongs to the glycerate kinase type-1 family
HIN88_04105	COG0243	molybdopterin cofactor binding
HIN88_04110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HIN88_04115	COG3339	Conserved Protein
HIN88_04125	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HIN88_04140	COG1113	amino acid transport
HIN88_04150	COG0019	diaminopimelate decarboxylase activity
HIN88_04160	COG1280	lysine exporter protein (LysE YggA)
HIN88_04165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HIN88_04195	COG0463	Glycosyl transferase, family 2
HIN88_04215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_04245	COG4591	ABC-type transport system involved in lipoprotein release permease component
HIN88_04250	COG1136	(ABC) transporter
HIN88_04255	COG2333	competence protein COMEC
HIN88_04255	COG0658	competence protein
HIN88_04265	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HIN88_04265	COG0616	signal peptide processing
HIN88_04270	COG0596	Alpha beta hydrolase
HIN88_04275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HIN88_04285	COG0628	permease
HIN88_04320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIN88_04340	COG0823	Involved in the tonB-independent uptake of proteins
HIN88_04360	COG0824	Thioesterase
HIN88_04365	COG1473	amidohydrolase
HIN88_04385	COG0047	phosphoribosylformylglycinamidine synthase activity
HIN88_04385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HIN88_04390	COG2814	Major facilitator Superfamily
HIN88_04400	COG1024	Enoyl-CoA hydratase
HIN88_04405	COG1051	belongs to the nudix hydrolase family
HIN88_04405	COG1056	cytidyltransferase-related domain
HIN88_04415	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HIN88_04430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HIN88_04445	COG4625	pathogenesis
HIN88_04450	COG0583	DNA-binding transcription factor activity
HIN88_04455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HIN88_04460	COG4208	sulfate ABC transporter
HIN88_04465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HIN88_04475	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HIN88_04480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HIN88_04485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HIN88_04505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HIN88_04520	COG0681	Belongs to the peptidase S26 family
HIN88_04535	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HIN88_04545	COG1381	Involved in DNA repair and RecF pathway recombination
HIN88_04550	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HIN88_04560	COG4221	oxidoreductase activity
HIN88_04590	COG0436	Aminotransferase
HIN88_04610	COG0556	nucleotide-excision repair
HIN88_04665	COG2070	2-Nitropropane dioxygenase
HIN88_04695	COG1215	transferase activity, transferring glycosyl groups
HIN88_04710	COG0415	Belongs to the DNA photolyase family
HIN88_04720	COG1252	NADH dehydrogenase
HIN88_04725	COG1686	Belongs to the peptidase S11 family
HIN88_04740	COG1187	pseudouridine synthase activity
HIN88_04840	COG0305	Participates in initiation and elongation during chromosome replication
HIN88_05020	COG0582	viral genome integration into host DNA
HIN88_05045	COG0477	Major facilitator Superfamily
HIN88_05050	COG0583	DNA-binding transcription factor activity
HIN88_05065	COG0612	Peptidase, M16
HIN88_05090	COG0352	thiamine-phosphate diphosphorylase activity
HIN88_05125	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN88_05140	COG1309	transcriptional regulator
HIN88_05150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HIN88_05155	COG0076	glutamate decarboxylase activity
HIN88_05165	COG1522	sequence-specific DNA binding
HIN88_05170	COG3961	Belongs to the TPP enzyme family
HIN88_05175	COG1113	amino acid transport
HIN88_05180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HIN88_05185	COG0573	inorganic phosphate transmembrane transporter activity
HIN88_05195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HIN88_05200	COG0616	signal peptide processing
HIN88_05235	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HIN88_05240	COG1686	Belongs to the peptidase S11 family
HIN88_05265	COG0583	DNA-binding transcription factor activity
HIN88_05270	COG1067	ATP-dependent peptidase activity
HIN88_05275	COG2211	Major facilitator Superfamily
HIN88_05295	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HIN88_05315	COG1966	Carbon starvation protein
HIN88_05320	COG2879	small protein
HIN88_05350	COG1741	Belongs to the pirin family
HIN88_05360	COG2964	Protein conserved in bacteria
HIN88_05375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN88_05380	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HIN88_05385	COG4605	iron ion homeostasis
HIN88_05390	COG4604	ABC transporter, ATP-binding protein
HIN88_05395	COG4607	ABC-type enterochelin transport system periplasmic component
HIN88_05400	COG4774	siderophore transport
HIN88_05410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HIN88_05415	COG1021	2,3-dihydroxybenzoate-AMP ligase
HIN88_05420	COG3433	isochorismatase activity
HIN88_05420	COG1535	isochorismatase
HIN88_05435	COG1132	(ABC) transporter
HIN88_05445	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HIN88_05455	COG1169	isochorismate synthase
HIN88_05470	COG3739	integral membrane protein
HIN88_05500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HIN88_05530	COG0308	aminopeptidase N
HIN88_05535	COG0512	Glutamine amidotransferase of anthranilate synthase
HIN88_05545	COG3104	oligopeptide transport
HIN88_05550	COG0174	glutamine synthetase
HIN88_05560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HIN88_05595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HIN88_05600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HIN88_05605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HIN88_05625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HIN88_05630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HIN88_05635	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HIN88_05650	COG1960	acyl-CoA dehydrogenase activity
HIN88_05655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HIN88_05660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIN88_05670	COG2223	nitrite transmembrane transporter activity
HIN88_05680	COG0024	Methionine aminopeptidase
HIN88_05685	COG0052	Belongs to the universal ribosomal protein uS2 family
HIN88_05700	COG2207	Transcriptional regulator
HIN88_05725	COG2951	lytic endotransglycosylase activity
HIN88_05730	COG0772	Belongs to the SEDS family
HIN88_05745	COG0842	Transport permease protein
HIN88_05750	COG1131	(ABC) transporter
HIN88_05790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_05805	COG4215	(ABC) transporter
HIN88_05810	COG4160	amino acid transport
HIN88_05815	COG4598	ABC transporter
HIN88_05825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIN88_05835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN88_05850	COG1720	tRNA m6t6A37 methyltransferase activity
HIN88_05870	COG0745	RESPONSE REGULATOR receiver
HIN88_05875	COG0642	Histidine kinase
HIN88_05885	COG0494	nUDIX hydrolase
HIN88_05895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HIN88_05900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HIN88_05905	COG3139	Protein of unknown function (DUF1315)
HIN88_05910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HIN88_05915	COG1301	dicarboxylic acid transport
HIN88_05920	COG1960	acyl-CoA dehydrogenase activity
HIN88_05925	COG2819	hydrolase of the alpha beta superfamily
HIN88_05935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HIN88_05945	COG2195	Cleaves the N-terminal amino acid of tripeptides
HIN88_05950	COG1234	tRNA 3'-trailer cleavage
HIN88_05980	COG2363	Small membrane protein
HIN88_06000	COG0513	Belongs to the DEAD box helicase family
HIN88_06010	COG0778	Nitroreductase
HIN88_06040	COG1286	toxin biosynthetic process
HIN88_06065	COG4783	chaperone-mediated protein folding
HIN88_06070	COG1610	YqeY-like protein
HIN88_06100	COG0515	serine threonine protein kinase
HIN88_06100	COG2815	serine threonine protein kinase
HIN88_06125	COG2831	hemolysin activation secretion protein
HIN88_06245	COG3111	PFAM Bacterial OB fold (BOF) protein
HIN88_06275	COG0786	glutamate:sodium symporter activity
HIN88_06285	COG2186	Transcriptional regulator
HIN88_06365	COG2995	paraquat-inducible protein a
HIN88_06370	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HIN88_06370	COG3008	intermembrane lipid transfer
HIN88_06380	COG2351	hydroxyisourate hydrolase activity
HIN88_06395	COG5002	protein histidine kinase activity
HIN88_06420	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIN88_06430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HIN88_06435	COG0642	Histidine kinase
HIN88_06440	COG0745	RESPONSE REGULATOR receiver
HIN88_06460	COG1794	racemase activity, acting on amino acids and derivatives
HIN88_06490	COG1301	dicarboxylic acid transport
HIN88_06500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN88_06505	COG2011	ABC-type metal ion transport system permease component
HIN88_06510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HIN88_06515	COG1464	Belongs to the NlpA lipoprotein family
HIN88_06520	COG0151	Belongs to the GarS family
HIN88_06525	COG0138	bifunctional purine biosynthesis protein purh
HIN88_06530	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HIN88_06560	COG2308	Evidence 4 Homologs of previously reported genes of
HIN88_06570	COG1305	Transglutaminase-like
HIN88_06580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HIN88_06585	COG0305	Participates in initiation and elongation during chromosome replication
HIN88_06610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HIN88_06620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HIN88_06625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HIN88_06650	COG0726	polysaccharide deacetylase
HIN88_06650	COG1649	PFAM Uncharacterised BCR, COG1649
HIN88_06655	COG1215	transferase activity, transferring glycosyl groups
HIN88_06660	COG3658	cytochrome
HIN88_06670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_06700	COG2890	protein-(glutamine-N5) methyltransferase activity
HIN88_06705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_06710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_06725	COG1960	acyl-CoA dehydrogenase activity
HIN88_06730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIN88_06735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_06760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HIN88_06765	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HIN88_06770	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HIN88_06775	COG2205	protein histidine kinase activity
HIN88_06780	COG0745	RESPONSE REGULATOR receiver
HIN88_06785	COG0174	glutamine synthetase
HIN88_06805	COG0729	surface antigen
HIN88_06830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HIN88_06835	COG2814	Major facilitator Superfamily
HIN88_06850	COG0583	DNA-binding transcription factor activity
HIN88_06865	COG1187	pseudouridine synthase activity
HIN88_06885	COG0802	atpase or kinase
HIN88_06890	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HIN88_06900	COG1923	regulation of RNA biosynthetic process
HIN88_06905	COG0697	spore germination
HIN88_06930	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIN88_06935	COG0519	Catalyzes the synthesis of GMP from XMP
HIN88_06935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HIN88_06940	COG4302	ethanolamine ammonia-lyase activity
HIN88_06945	COG4303	Ethanolamine ammonia lyase large subunit
HIN88_06950	COG0531	amino acid
HIN88_06970	COG1454	alcohol dehydrogenase
HIN88_06975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN88_06985	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HIN88_07005	COG0308	aminopeptidase N
HIN88_07045	COG1605	Chorismate mutase
HIN88_07060	COG1309	transcriptional regulator
HIN88_07070	COG0668	transmembrane transport
HIN88_07100	COG4773	Receptor
HIN88_07120	COG0488	(ABC) transporter
HIN88_07125	COG0589	response to stress
HIN88_07150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HIN88_07160	COG3135	benzoate transporter
HIN88_07165	COG1522	sequence-specific DNA binding
HIN88_07175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HIN88_07180	COG0583	DNA-binding transcription factor activity
HIN88_07190	COG0183	Belongs to the thiolase family
HIN88_07200	COG2030	dehydratase
HIN88_07220	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HIN88_07230	COG0824	Thioesterase
HIN88_07235	COG1454	alcohol dehydrogenase
HIN88_07245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HIN88_07265	COG0069	glutamate synthase activity
HIN88_07285	COG2814	Major facilitator Superfamily
HIN88_07300	COG0511	ligase activity, forming carbon-carbon bonds
HIN88_07320	COG1116	anion transmembrane transporter activity
HIN88_07320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_07325	COG0745	RESPONSE REGULATOR receiver
HIN88_07335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN88_07335	COG2146	nitrite reductase [NAD(P)H] activity
HIN88_07340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN88_07345	COG0243	molybdopterin cofactor binding
HIN88_07355	COG0243	molybdopterin cofactor binding
HIN88_07360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HIN88_07375	COG0315	cyclic pyranopterin monophosphate synthase activity
HIN88_07375	COG0521	Mo-molybdopterin cofactor biosynthetic process
HIN88_07380	COG0303	'Molybdopterin
HIN88_07395	COG0697	spore germination
HIN88_07415	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HIN88_07420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIN88_07475	COG2204	response regulator
HIN88_07480	COG3852	Histidine kinase
HIN88_07500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HIN88_07505	COG0575	Belongs to the CDS family
HIN88_07520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIN88_07540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIN88_07555	COG2137	regulation of response to DNA damage stimulus
HIN88_07565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HIN88_07570	COG1011	Hydrolase
HIN88_07595	COG1522	sequence-specific DNA binding
HIN88_07605	COG1113	amino acid transport
HIN88_07620	COG0659	secondary active sulfate transmembrane transporter activity
HIN88_07625	COG2135	peptidase activity
HIN88_07640	COG5001	Diguanylate cyclase
HIN88_07640	COG3300	MHYT domain
HIN88_07655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIN88_07655	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HIN88_07655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HIN88_07660	COG1105	Belongs to the carbohydrate kinase PfkB family
HIN88_07665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIN88_07665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HIN88_07695	COG0024	Methionine aminopeptidase
HIN88_07700	COG0583	DNA-binding transcription factor activity
HIN88_07710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HIN88_07715	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HIN88_07720	COG0517	IMP dehydrogenase activity
HIN88_07720	COG0516	GMP reductase activity
HIN88_07745	COG0552	protein localization to endoplasmic reticulum
HIN88_07755	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
HIN88_07770	COG4890	Cyd operon protein YbgT
HIN88_07775	COG1294	oxidase, subunit
HIN88_07790	COG1585	Membrane protein implicated in regulation of membrane protease activity
HIN88_07800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HIN88_07805	COG4774	siderophore transport
HIN88_07820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HIN88_07825	COG0569	domain protein
HIN88_07830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HIN88_07860	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HIN88_07865	COG0542	response to heat
HIN88_07890	COG1902	pentaerythritol trinitrate reductase activity
HIN88_07890	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIN88_07935	COG2323	membrane
HIN88_07940	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HIN88_07950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HIN88_07955	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HIN88_07960	COG0183	Belongs to the thiolase family
HIN88_07965	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HIN88_07970	COG0596	Alpha beta hydrolase
HIN88_07975	COG2271	Major facilitator Superfamily
HIN88_07980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HIN88_07985	COG3485	protocatechuate 3,4-dioxygenase
HIN88_07990	COG3485	protocatechuate 3,4-dioxygenase
HIN88_07995	COG0710	3-dehydroquinate dehydratase activity
HIN88_08000	COG3420	alginic acid biosynthetic process
HIN88_08005	COG3659	wide pore channel activity
HIN88_08010	COG4993	Dehydrogenase
HIN88_08020	COG2391	methyltransferase activity
HIN88_08035	COG1414	Transcriptional regulator
HIN88_08040	COG0583	DNA-binding transcription factor activity
HIN88_08045	COG1960	acyl-CoA dehydrogenase activity
HIN88_08070	COG2814	Major facilitator Superfamily
HIN88_08080	COG0154	amidase activity
HIN88_08100	COG4638	Rieske (2fe-2S)
HIN88_08110	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_08120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_08130	COG3733	amine oxidase
HIN88_08140	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_08145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIN88_08150	COG0183	Belongs to the thiolase family
HIN88_08155	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HIN88_08160	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HIN88_08170	COG4829	muconolactone delta-isomerase
HIN88_08175	COG4948	Mandelate Racemase Muconate Lactonizing
HIN88_08180	COG0583	DNA-binding transcription factor activity
HIN88_08190	COG2186	Transcriptional regulator
HIN88_08210	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_08215	COG3231	kanamycin kinase activity
HIN88_08230	COG1960	acyl-CoA dehydrogenase activity
HIN88_08235	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_08240	COG3829	transcription factor binding
HIN88_08250	COG3162	membrane
HIN88_08265	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_08280	COG0753	catalase activity
HIN88_08305	COG1846	Transcriptional regulator
HIN88_08310	COG1902	pentaerythritol trinitrate reductase activity
HIN88_08310	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIN88_08320	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HIN88_08350	COG1309	transcriptional regulator
HIN88_08355	COG0583	DNA-binding transcription factor activity
HIN88_08360	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_08365	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_08370	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_08380	COG1960	acyl-CoA dehydrogenase activity
HIN88_08390	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_08455	COG2188	Transcriptional regulator
HIN88_08470	COG0583	DNA-binding transcription factor activity
HIN88_08500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HIN88_08510	COG1566	PFAM secretion protein HlyD family protein
HIN88_08525	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_08530	COG0129	dihydroxy-acid dehydratase activity
HIN88_08540	COG0583	DNA-binding transcription factor activity
HIN88_08545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HIN88_08555	COG2084	Dehydrogenase
HIN88_08560	COG2207	Transcriptional regulator
HIN88_08565	COG1064	alcohol dehydrogenase
HIN88_08580	COG1120	ATPase activity
HIN88_08600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIN88_08650	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HIN88_08680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN88_08715	COG1073	alpha beta
HIN88_08725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HIN88_08755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIN88_08760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_08765	COG0745	RESPONSE REGULATOR receiver
HIN88_08770	COG2205	protein histidine kinase activity
HIN88_08785	COG2072	flavoprotein involved in K transport
HIN88_08865	COG2175	clavaminate synthase activity
HIN88_08870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HIN88_08885	COG0667	Aldo Keto reductase
HIN88_08890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_08905	COG2175	clavaminate synthase activity
HIN88_08935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_08940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_08945	COG4771	TonB-dependent receptor
HIN88_08975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_08980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_08985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_08990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_09005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HIN88_09020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_09040	COG1132	(ABC) transporter
HIN88_09045	COG1132	(ABC) transporter
HIN88_09065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIN88_09070	COG0601	transmembrane transport
HIN88_09100	COG3539	Fimbrial protein
HIN88_09125	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HIN88_09135	COG0753	catalase activity
HIN88_09150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HIN88_09215	COG3433	isochorismatase activity
HIN88_09215	COG1535	isochorismatase
HIN88_09220	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_09225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HIN88_09230	COG4149	molybdate abc transporter
HIN88_09235	COG0725	ABC transporter, periplasmic molybdate-binding protein
HIN88_09245	COG4638	Rieske (2fe-2S)
HIN88_09250	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HIN88_09255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN88_09255	COG0543	2 iron, 2 sulfur cluster binding
HIN88_09270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_09280	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_09295	COG2207	Transcriptional regulator
HIN88_09300	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_09305	COG2610	gluconate transmembrane transporter activity
HIN88_09315	COG0583	DNA-binding transcription factor activity
HIN88_09330	COG2031	fatty acid transporter
HIN88_09335	COG0183	Belongs to the thiolase family
HIN88_09340	COG0583	DNA-binding transcription factor activity
HIN88_09345	COG0583	DNA-binding transcription factor activity
HIN88_09360	COG1027	Aspartate ammonia-lyase
HIN88_09370	COG0477	Major facilitator Superfamily
HIN88_09390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_09395	COG4521	taurine ABC transporter
HIN88_09410	COG2188	Transcriptional regulator
HIN88_09420	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HIN88_09425	COG1733	regulation of RNA biosynthetic process
HIN88_09430	COG2207	Transcriptional regulator
HIN88_09430	COG3708	Transcriptional regulator
HIN88_09445	COG0730	response to heat
HIN88_09455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN88_09455	COG3453	Protein conserved in bacteria
HIN88_09465	COG3781	membrane
HIN88_09470	COG1063	alcohol dehydrogenase
HIN88_09480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HIN88_09485	COG0508	dehydrogenase complex catalyzes the overall conversion of
HIN88_09490	COG0022	dehydrogenase e1 component
HIN88_09495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HIN88_09500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HIN88_09515	COG3706	GGDEF domain
HIN88_09530	COG0133	tryptophan synthase activity
HIN88_09540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HIN88_09575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HIN88_09600	COG2226	methyltransferase
HIN88_09655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HIN88_09660	COG4773	Receptor
HIN88_09680	COG0730	response to heat
HIN88_09685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HIN88_09700	COG0406	alpha-ribazole phosphatase activity
HIN88_09705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HIN88_09720	COG0246	Mannitol dehydrogenase
HIN88_09750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HIN88_09760	COG4264	IucA IucC family
HIN88_09765	COG4264	IucA IucC family
HIN88_09785	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HIN88_09800	COG1960	acyl-CoA dehydrogenase activity
HIN88_09805	COG1960	acyl-CoA dehydrogenase activity
HIN88_09810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIN88_09815	COG2207	Transcriptional regulator
HIN88_09820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HIN88_09825	COG0776	regulation of translation
HIN88_09850	COG0822	iron-sulfur transferase activity
HIN88_09855	COG0316	Belongs to the HesB IscA family
HIN88_09885	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HIN88_09905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HIN88_09910	COG0702	epimerase
HIN88_09945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HIN88_09955	COG0339	signal peptide processing
HIN88_10005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HIN88_10010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HIN88_10040	COG0776	regulation of translation
HIN88_10105	COG0084	hydrolase, TatD family'
HIN88_10125	COG1663	tetraacyldisaccharide 4'-kinase activity
HIN88_10130	COG1132	(ABC) transporter
HIN88_10140	COG0811	peptide transport
HIN88_10145	COG1475	DNA binding
HIN88_10150	COG1192	Involved in chromosome partitioning
HIN88_10160	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HIN88_10175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HIN88_10180	COG0191	fructose-bisphosphate aldolase activity
HIN88_10200	COG0424	maF-like protein
HIN88_10205	COG2850	peptidyl-arginine hydroxylation
HIN88_10215	COG0640	Transcriptional regulator
HIN88_10225	COG3619	membrane
HIN88_10230	COG3122	Protein conserved in bacteria
HIN88_10235	COG1132	(ABC) transporter
HIN88_10255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HIN88_10260	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HIN88_10270	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HIN88_10270	COG0506	proline dehydrogenase activity
HIN88_10270	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HIN88_10275	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HIN88_10290	COG3698	Phosphodiester glycosidase
HIN88_10300	COG2353	YceI-like domain
HIN88_10310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HIN88_10380	COG3539	Fimbrial protein
HIN88_10385	COG3121	Chaperone
HIN88_10410	COG0697	spore germination
HIN88_10420	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HIN88_10430	COG0583	DNA-binding transcription factor activity
HIN88_10450	COG1309	transcriptional regulator
HIN88_10465	COG1522	sequence-specific DNA binding
HIN88_10475	COG1126	abc transporter atp-binding protein
HIN88_10480	COG0765	amino acid transport
HIN88_10485	COG0765	amino acid transport
HIN88_10515	COG1464	Belongs to the NlpA lipoprotein family
HIN88_10525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HIN88_10530	COG2011	ABC-type metal ion transport system permease component
HIN88_10535	COG0012	GTP binding
HIN88_10560	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HIN88_10600	COG0386	Belongs to the glutathione peroxidase family
HIN88_10610	COG0436	Aminotransferase
HIN88_10650	COG3634	alkyl hydroperoxide reductase activity
HIN88_10665	COG0583	DNA-binding transcription factor activity
HIN88_10670	COG0798	PFAM Bile acid sodium symporter
HIN88_10675	COG0640	Transcriptional regulator
HIN88_10690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HIN88_10700	COG0583	DNA-binding transcription factor activity
HIN88_10710	COG1953	Uracil, thiamine, allantoin
HIN88_10720	COG2175	clavaminate synthase activity
HIN88_10725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_10730	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HIN88_10735	COG4521	taurine ABC transporter
HIN88_10745	COG0477	Major facilitator Superfamily
HIN88_10765	COG1271	oxidase subunit
HIN88_10770	COG1294	oxidase, subunit
HIN88_10780	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN88_10800	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HIN88_10820	COG3052	prosthetic group binding
HIN88_10825	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HIN88_10835	COG2814	Major facilitator Superfamily
HIN88_10855	COG1346	cytolysis
HIN88_10865	COG0583	DNA-binding transcription factor activity
HIN88_10870	COG0625	glutathione transferase activity
HIN88_10875	COG0625	glutathione transferase activity
HIN88_10880	COG0583	DNA-binding transcription factor activity
HIN88_10895	COG1045	serine acetyltransferase
HIN88_10900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HIN88_10905	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HIN88_10910	COG1280	lysine exporter protein (LysE YggA)
HIN88_10925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIN88_10930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HIN88_10935	COG1126	abc transporter atp-binding protein
HIN88_10940	COG0765	amino acid transport
HIN88_10945	COG0765	amino acid transport
HIN88_11000	COG2205	protein histidine kinase activity
HIN88_11000	COG0784	Response regulator, receiver
HIN88_11040	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_11090	COG0583	DNA-binding transcription factor activity
HIN88_11110	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_11115	COG1309	transcriptional regulator
HIN88_11120	COG1960	acyl-CoA dehydrogenase activity
HIN88_11125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HIN88_11130	COG1024	Enoyl-CoA hydratase
HIN88_11135	COG4770	biotin carboxylase activity
HIN88_11145	COG0583	DNA-binding transcription factor activity
HIN88_11160	COG1960	acyl-CoA dehydrogenase activity
HIN88_11170	COG2814	Major facilitator Superfamily
HIN88_11180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HIN88_11185	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HIN88_11190	COG2814	Major facilitator Superfamily
HIN88_11195	COG1960	acyl-CoA dehydrogenase activity
HIN88_11200	COG1024	Enoyl-CoA hydratase
HIN88_11205	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_11210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIN88_11215	COG0183	Belongs to the thiolase family
HIN88_11225	COG2814	Major facilitator Superfamily
HIN88_11235	COG1024	Enoyl-CoA hydratase
HIN88_11265	COG1063	alcohol dehydrogenase
HIN88_11270	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIN88_11290	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HIN88_11300	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_11305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN88_11310	COG2271	Major facilitator Superfamily
HIN88_11320	COG2186	Transcriptional regulator
HIN88_11345	COG0038	chloride channel
HIN88_11350	COG4770	biotin carboxylase activity
HIN88_11370	COG1914	H( )-stimulated, divalent metal cation uptake system
HIN88_11375	COG0583	DNA-binding transcription factor activity
HIN88_11410	COG1250	3-hydroxyacyl-CoA dehydrogenase
HIN88_11430	COG2814	Major facilitator Superfamily
HIN88_11460	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HIN88_11470	COG4122	O-methyltransferase activity
HIN88_11500	COG1538	Outer membrane efflux protein
HIN88_11510	COG1137	ATPase activity
HIN88_11515	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HIN88_11525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HIN88_11575	COG2814	Major facilitator Superfamily
HIN88_11610	COG1278	Cold shock
HIN88_11615	COG1280	lysine exporter protein (LysE YggA)
HIN88_11650	COG1570	exodeoxyribonuclease VII activity
HIN88_11700	COG0583	DNA-binding transcription factor activity
HIN88_11705	COG4638	Rieske (2fe-2S)
HIN88_11710	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HIN88_11715	COG0633	Ferredoxin
HIN88_11715	COG0543	2 iron, 2 sulfur cluster binding
HIN88_11720	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_11725	COG3135	benzoate transporter
HIN88_11730	COG2814	Major facilitator Superfamily
HIN88_11745	COG1643	Atp-dependent helicase
HIN88_11750	COG0450	alkyl hydroperoxide reductase
HIN88_11760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HIN88_11770	COG3634	alkyl hydroperoxide reductase activity
HIN88_11790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HIN88_11795	COG0625	glutathione transferase activity
HIN88_11805	COG2885	chlorophyll binding
HIN88_11840	COG0542	response to heat
HIN88_11855	COG1765	OsmC-like protein
HIN88_11865	COG0667	Aldo Keto reductase
HIN88_11880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HIN88_11890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HIN88_11900	COG0582	viral genome integration into host DNA
HIN88_11905	COG2194	sulfuric ester hydrolase activity
HIN88_11945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HIN88_11970	COG2314	TM2 domain
HIN88_12025	COG3566	protein conserved in bacteria
HIN88_12040	COG3567	Phage-associated protein, HI1409 family
HIN88_12045	COG5410	chromosome segregation
HIN88_12145	COG4197	protein conserved in bacteria, prophage-related
HIN88_12150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIN88_12205	COG0527	aspartate kinase activity
HIN88_12215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HIN88_12225	COG3038	cytochrome b561
HIN88_12230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HIN88_12235	COG2252	PERMEase
HIN88_12245	COG2072	flavoprotein involved in K transport
HIN88_12260	COG1741	Belongs to the pirin family
HIN88_12265	COG1309	transcriptional regulator
HIN88_12275	COG0300	oxidoreductase activity
HIN88_12280	COG2072	flavoprotein involved in K transport
HIN88_12285	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HIN88_12290	COG0583	DNA-binding transcription factor activity
HIN88_12305	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HIN88_12350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HIN88_12365	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HIN88_12380	COG2814	Major facilitator Superfamily
HIN88_12385	COG1024	Enoyl-CoA hydratase
HIN88_12390	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_12400	COG1960	acyl-CoA dehydrogenase activity
HIN88_12425	COG2186	Transcriptional regulator
HIN88_12430	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_12440	COG4948	Mandelate Racemase Muconate Lactonizing
HIN88_12445	COG2271	Major facilitator Superfamily
HIN88_12450	COG2721	sulfolactate sulfo-lyase activity
HIN88_12455	COG0697	spore germination
HIN88_12485	COG3210	domain, Protein
HIN88_12490	COG2831	hemolysin activation secretion protein
HIN88_12495	COG1113	amino acid transport
HIN88_12515	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_12535	COG0531	amino acid
HIN88_12545	COG1113	amino acid transport
HIN88_12590	COG4269	membrane
HIN88_12605	COG1902	pentaerythritol trinitrate reductase activity
HIN88_12605	COG0446	pyridine nucleotide-disulphide oxidoreductase
HIN88_12615	COG3706	GGDEF domain
HIN88_12615	COG2203	Gaf domain
HIN88_12615	COG4251	negative regulation of phosphorylation
HIN88_12615	COG5001	Diguanylate cyclase
HIN88_12625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIN88_12650	COG4172	Belongs to the ABC transporter superfamily
HIN88_12655	COG4239	(ABC) transporter, permease
HIN88_12660	COG4174	ABC transporter (Permease)
HIN88_12670	COG1388	LysM domain
HIN88_12670	COG1388	LysM domain
HIN88_12670	COG0741	lytic transglycosylase activity
HIN88_12670	COG0741	lytic transglycosylase activity
HIN88_12675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HIN88_12715	COG0583	DNA-binding transcription factor activity
HIN88_12720	COG1279	arginine transmembrane transporter activity
HIN88_12740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN88_12745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HIN88_12750	COG0006	proline dipeptidase activity
HIN88_12840	COG1196	nuclear chromosome segregation
HIN88_12840	COG0739	heme binding
HIN88_12840	COG0741	lytic transglycosylase activity
HIN88_12900	COG4695	Portal protein
HIN88_13000	COG0305	Participates in initiation and elongation during chromosome replication
HIN88_13280	COG5410	chromosome segregation
HIN88_13380	COG3620	sequence-specific DNA binding
HIN88_13455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HIN88_13480	COG3384	dioxygenase
HIN88_13490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HIN88_13495	COG2878	Part of a membrane complex involved in electron transport
HIN88_13500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HIN88_13525	COG0768	penicillin binding
HIN88_13530	COG0742	ribosomal rna small subunit methyltransferase
HIN88_13545	COG0830	nickel cation binding
HIN88_13555	COG0804	urea catabolic process
HIN88_13600	COG1253	flavin adenine dinucleotide binding
HIN88_13605	COG2851	Citrate transporter
HIN88_13655	COG1773	rubredoxin
HIN88_13660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HIN88_13670	COG0583	DNA-binding transcription factor activity
HIN88_13700	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HIN88_13705	COG4181	ATPase activity
HIN88_13750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HIN88_13770	COG0306	phosphate transporter
HIN88_13780	COG3958	Transketolase
HIN88_13785	COG3959	Transketolase, thiamine diphosphate binding domain
HIN88_13790	COG2271	Major facilitator Superfamily
HIN88_13795	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_13800	COG0583	DNA-binding transcription factor activity
HIN88_13815	COG2223	nitrite transmembrane transporter activity
HIN88_13820	COG2207	Transcriptional regulator
HIN88_13825	COG2066	Belongs to the glutaminase family
HIN88_13830	COG0242	peptide deformylase activity
HIN88_13835	COG0477	Major facilitator Superfamily
HIN88_13845	COG0028	Belongs to the TPP enzyme family
HIN88_13850	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_13860	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_13865	COG2267	carboxylic ester hydrolase activity
HIN88_13875	COG2271	Major facilitator Superfamily
HIN88_13890	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_13910	COG1414	Transcriptional regulator
HIN88_13925	COG1024	Enoyl-CoA hydratase
HIN88_13935	COG1215	transferase activity, transferring glycosyl groups
HIN88_13940	COG1649	PFAM Uncharacterised BCR, COG1649
HIN88_13940	COG0726	polysaccharide deacetylase
HIN88_13950	COG4681	YaeQ
HIN88_13960	COG0523	cobalamin synthesis protein
HIN88_13970	COG1607	acyl-coa hydrolase
HIN88_13980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HIN88_13985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HIN88_13990	COG1309	transcriptional regulator
HIN88_14015	COG2040	homocysteine
HIN88_14020	COG0531	amino acid
HIN88_14045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN88_14050	COG0477	Major facilitator Superfamily
HIN88_14140	COG0582	viral genome integration into host DNA
HIN88_14150	COG0405	Gamma-glutamyltransferase
HIN88_14155	COG2814	Major facilitator Superfamily
HIN88_14165	COG2050	protein possibly involved in aromatic compounds catabolism
HIN88_14180	COG1090	epimerase
HIN88_14200	COG0420	3'-5' exonuclease activity
HIN88_14225	COG0735	belongs to the Fur family
HIN88_14230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HIN88_14250	COG0121	glutamine amidotransferase
HIN88_14265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIN88_14275	COG0210	DNA helicase
HIN88_14280	COG2885	chlorophyll binding
HIN88_14285	COG0204	Acyl-transferase
HIN88_14300	COG2894	cell division
HIN88_14315	COG1280	lysine exporter protein (LysE YggA)
HIN88_14320	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HIN88_14320	COG1674	ftsk spoiiie
HIN88_14325	COG0492	ferredoxin-NADP+ reductase activity
HIN88_14330	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HIN88_14340	COG0456	acetyltransferase
HIN88_14400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HIN88_14400	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIN88_14420	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_14440	COG0473	3-isopropylmalate dehydrogenase activity
HIN88_14445	COG0583	DNA-binding transcription factor activity
HIN88_14465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HIN88_14490	COG0564	pseudouridine synthase activity
HIN88_14500	COG0358	DNA primase activity
HIN88_14515	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HIN88_14545	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HIN88_14575	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HIN88_14585	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HIN88_14585	COG0352	thiamine-phosphate diphosphorylase activity
HIN88_14585	COG0351	phosphomethylpyrimidine kinase
HIN88_14590	COG1652	LysM domain
HIN88_14615	COG1399	metal-binding, possibly nucleic acid-binding protein
HIN88_14620	COG3101	peptidyl-lysine hydroxylation
HIN88_14625	COG0009	L-threonylcarbamoyladenylate synthase
HIN88_14630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HIN88_14635	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HIN88_14650	COG4106	trans-aconitate 2-methyltransferase activity
HIN88_14665	COG2226	methyltransferase
HIN88_14665	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIN88_14665	COG0596	Alpha beta hydrolase
HIN88_14670	COG1877	trehalose-phosphatase activity
HIN88_14675	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HIN88_14680	COG2223	nitrite transmembrane transporter activity
HIN88_14700	COG1196	nuclear chromosome segregation
HIN88_14710	COG0730	response to heat
HIN88_14725	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HIN88_14735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIN88_14785	COG0489	protein tyrosine kinase activity
HIN88_14795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIN88_14795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIN88_14825	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HIN88_14830	COG2081	HI0933 family
HIN88_14840	COG0668	transmembrane transport
HIN88_14860	COG0583	DNA-binding transcription factor activity
HIN88_14880	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HIN88_14885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HIN88_14915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HIN88_14950	COG2205	protein histidine kinase activity
HIN88_14955	COG0745	RESPONSE REGULATOR receiver
HIN88_14975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HIN88_15040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HIN88_15065	COG1473	amidohydrolase
HIN88_15075	COG0583	DNA-binding transcription factor activity
HIN88_15090	COG0583	DNA-binding transcription factor activity
HIN88_15095	COG1053	succinate dehydrogenase
HIN88_15105	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HIN88_15110	COG2814	Major facilitator Superfamily
HIN88_15115	COG1960	acyl-CoA dehydrogenase activity
HIN88_15120	COG0583	DNA-binding transcription factor activity
HIN88_15125	COG1063	alcohol dehydrogenase
HIN88_15155	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HIN88_15160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HIN88_15165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HIN88_15180	COG3667	copper resistance
HIN88_15185	COG2132	Multicopper oxidase
HIN88_15195	COG0561	phosphatase activity
HIN88_15200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HIN88_15225	COG1214	PFAM Peptidase M22, glycoprotease
HIN88_15275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HIN88_15285	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HIN88_15290	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HIN88_15295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HIN88_15355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HIN88_15365	COG1846	Transcriptional regulator
HIN88_15370	COG1764	response to oxidative stress
HIN88_15410	COG0037	tRNA processing
HIN88_15420	COG0248	Ppx GppA phosphatase
HIN88_15450	COG0072	phenylalanine-tRNA ligase activity
HIN88_15490	COG1238	metal cluster binding
HIN88_15495	COG0625	glutathione transferase activity
HIN88_15510	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_15515	COG3028	Belongs to the UPF0307 family
HIN88_15520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HIN88_15540	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HIN88_15545	COG0617	tRNA 3'-terminal CCA addition
HIN88_15550	COG1555	photosystem II stabilization
HIN88_15555	COG3956	TIGRFAM MazG family protein
HIN88_15565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HIN88_15585	COG2205	protein histidine kinase activity
HIN88_15585	COG5002	protein histidine kinase activity
HIN88_15585	COG0784	Response regulator, receiver
HIN88_15590	COG1024	Enoyl-CoA hydratase
HIN88_15595	COG2084	Dehydrogenase
HIN88_15600	COG3622	Belongs to the hyi family
HIN88_15630	COG0697	spore germination
HIN88_15640	COG2814	Major facilitator Superfamily
HIN88_15645	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HIN88_15655	COG0583	DNA-binding transcription factor activity
HIN88_15665	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HIN88_15675	COG0084	hydrolase, TatD family'
HIN88_15690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HIN88_15720	COG0440	acetolactate synthase activity
HIN88_15725	COG0028	Belongs to the TPP enzyme family
HIN88_15750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HIN88_15755	COG0577	efflux transmembrane transporter activity
HIN88_15755	COG1136	(ABC) transporter
HIN88_15775	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HIN88_15780	COG1162	GTPase activity
HIN88_15790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HIN88_15830	COG1426	Protein conserved in bacteria
HIN88_15865	COG0793	Belongs to the peptidase S41A family
HIN88_15880	COG2267	carboxylic ester hydrolase activity
HIN88_15890	COG1012	belongs to the aldehyde dehydrogenase family
HIN88_15895	COG3265	gluconokinase activity
HIN88_15905	COG0800	Aldolase
HIN88_15915	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HIN88_15920	COG0280	phosphate acetyltransferase
HIN88_15920	COG0857	belongs to the CobB CobQ family
HIN88_15925	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HIN88_15925	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HIN88_15945	COG0740	serine-type endopeptidase activity
HIN88_15955	COG4774	siderophore transport
HIN88_15965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HIN88_15975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HIN88_15975	COG2813	Specifically methylates the guanine in position
HIN88_16075	COG0788	formyltetrahydrofolate deformylase activity
HIN88_16100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HIN88_16100	COG4651	solute:proton antiporter activity
HIN88_16120	COG0724	RNA recognition motif
HIN88_16125	COG0210	DNA helicase
HIN88_16150	COG1733	regulation of RNA biosynthetic process
HIN88_16160	COG2900	Belongs to the SlyX family
HIN88_16175	COG1280	lysine exporter protein (LysE YggA)
HIN88_16180	COG1560	Kdo2-lipid A biosynthetic process
HIN88_16190	COG1301	dicarboxylic acid transport
HIN88_16245	COG0473	3-isopropylmalate dehydrogenase activity
HIN88_16300	COG0583	DNA-binding transcription factor activity
HIN88_16310	COG0625	glutathione transferase activity
HIN88_16315	COG2378	regulation of single-species biofilm formation
HIN88_16320	COG0546	phosphoglycolate phosphatase activity
HIN88_16335	COG1530	ribonuclease E activity
HIN88_16340	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_16355	COG0583	DNA-binding transcription factor activity
HIN88_16360	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_16365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HIN88_16375	COG0534	Mate efflux family protein
HIN88_16390	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HIN88_16430	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HIN88_16435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HIN88_16450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HIN88_16460	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HIN88_16460	COG0644	oxidoreductase
HIN88_16470	COG0425	Belongs to the sulfur carrier protein TusA family
HIN88_16475	COG4535	Mg2 and Co2 transporter CorC
HIN88_16485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HIN88_16505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HIN88_16510	COG0475	glutathione-regulated potassium exporter activity
HIN88_16510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HIN88_16525	COG0484	heat shock protein binding
HIN88_16530	COG0789	Transcriptional regulator
HIN88_16535	COG0598	Magnesium transport protein CorA
HIN88_16555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN88_16560	COG1074	ATP-dependent DNA helicase activity
HIN88_16565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HIN88_16585	COG2226	methyltransferase
HIN88_16615	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HIN88_16630	COG2111	Na H antiporter
HIN88_16630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HIN88_16635	COG1006	Multisubunit Na H antiporter MnhC subunit
HIN88_16640	COG0651	ATP synthesis coupled electron transport
HIN88_16650	COG2212	antiporter activity
HIN88_16670	COG0195	Participates in both transcription termination and antitermination
HIN88_16720	COG0237	dephospho-CoA kinase activity
HIN88_16730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HIN88_16745	COG0497	DNA recombination
HIN88_16755	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HIN88_16785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HIN88_16785	COG2169	Transcriptional regulator
HIN88_16790	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HIN88_16855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HIN88_16870	COG0326	Molecular chaperone. Has ATPase activity
HIN88_16885	COG2056	Na+-H+ antiporter family
HIN88_16890	COG0596	Alpha beta hydrolase
HIN88_16985	COG0546	phosphoglycolate phosphatase activity
HIN88_16990	COG1716	ATPase activity
HIN88_17035	COG0181	hydroxymethylbilane synthase activity
HIN88_17045	COG3275	phosphorelay sensor kinase activity
HIN88_17065	COG1538	Outer membrane efflux protein
HIN88_17070	COG0697	spore germination
HIN88_17095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HIN88_17100	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HIN88_17105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HIN88_17110	COG0772	Belongs to the SEDS family
HIN88_17135	COG4974	Belongs to the 'phage' integrase family
HIN88_17140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIN88_17150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HIN88_17160	COG2197	response regulator
HIN88_17175	COG0793	Belongs to the peptidase S41A family
HIN88_17180	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HIN88_17185	COG0795	lipopolysaccharide-transporting ATPase activity
HIN88_17225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIN88_17225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HIN88_17235	COG0004	ammonium transporteR
HIN88_17240	COG0347	Belongs to the P(II) protein family
HIN88_17250	COG0606	chelatase, subunit chli
HIN88_17280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HIN88_17325	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HIN88_17350	COG2132	Multicopper oxidase
HIN88_17365	COG2205	protein histidine kinase activity
HIN88_17370	COG2217	Heavy metal translocating P-type atpase
HIN88_17420	COG0606	chelatase, subunit chli
HIN88_17425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HIN88_17430	COG0235	Class ii aldolase
HIN88_17435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HIN88_17450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HIN88_17465	COG0318	PFAM AMP-dependent synthetase and ligase
HIN88_17475	COG0477	Major facilitator Superfamily
HIN88_17480	COG2860	membrane
HIN88_17490	COG1253	flavin adenine dinucleotide binding
HIN88_17500	COG0477	Major facilitator Superfamily
HIN88_17510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HIN88_17545	COG0655	NAD(P)H dehydrogenase (quinone) activity
HIN88_17555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HIN88_17590	COG1309	transcriptional regulator
HIN88_17625	COG0758	DNA mediated transformation
HIN88_17635	COG0697	spore germination
HIN88_17640	COG1309	transcriptional regulator
HIN88_17655	COG0386	Belongs to the glutathione peroxidase family
HIN88_17720	COG1121	(ABC) transporter
HIN88_17725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HIN88_17730	COG1280	lysine exporter protein (LysE YggA)
HIN88_17735	COG2837	iron assimilation
HIN88_17740	COG0281	malic enzyme
HIN88_17785	COG0519	Catalyzes the synthesis of GMP from XMP
HIN88_17785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HIN88_17790	COG4399	Belongs to the UPF0754 family
HIN88_17795	COG2259	Doxx family
HIN88_17800	COG0586	Pfam SNARE associated Golgi protein
HIN88_17815	COG1192	Involved in chromosome partitioning
HIN88_17825	COG0271	Belongs to the BolA IbaG family
HIN88_17845	COG2267	carboxylic ester hydrolase activity
HIN88_17865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HIN88_17865	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HIN88_17865	COG3321	synthase
HIN88_17865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HIN88_17870	COG1960	acyl-CoA dehydrogenase activity
HIN88_17880	COG2197	response regulator
HIN88_17890	COG3916	Acyl-homoserine-lactone synthase
HIN88_17895	COG0477	Major facilitator Superfamily
HIN88_17900	COG1024	Enoyl-CoA hydratase
HIN88_17905	COG1024	Enoyl-CoA hydratase
HIN88_17910	COG1960	acyl-CoA dehydrogenase activity
HIN88_17915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HIN88_17935	COG1113	amino acid transport
HIN88_17940	COG1113	amino acid transport
HIN88_17945	COG0251	oxidation-reduction process
HIN88_17985	COG0564	pseudouridine synthase activity
HIN88_18060	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HIN88_18075	COG1802	Transcriptional regulator
HIN88_18080	COG1448	Aminotransferase
HIN88_18085	COG0277	FAD linked oxidase domain protein
HIN88_18095	COG2186	Transcriptional regulator
HIN88_18105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HIN88_18115	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HIN88_18130	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HIN88_18135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HIN88_18145	COG0438	transferase activity, transferring glycosyl groups
HIN88_18155	COG0438	transferase activity, transferring glycosyl groups
HIN88_18160	COG1215	transferase activity, transferring glycosyl groups
HIN88_18170	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HIN88_18200	COG0728	peptidoglycan biosynthetic process
HIN88_18205	COG3023	N-Acetylmuramoyl-L-alanine amidase
HIN88_18260	COG0546	phosphoglycolate phosphatase activity
HIN88_18265	COG1028	Short-chain dehydrogenase reductase Sdr
HIN88_18285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_18290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HIN88_18295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HIN88_18300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HIN88_18305	COG1116	anion transmembrane transporter activity
HIN88_18310	COG1309	transcriptional regulator
HIN88_18315	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HIN88_18325	COG0196	riboflavin kinase activity
HIN88_18330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HIN88_18340	COG1047	Peptidyl-prolyl cis-trans
HIN88_18380	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HIN88_18435	COG2951	lytic endotransglycosylase activity
HIN88_18440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HIN88_18455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HIN88_18465	COG0671	phosphoesterase, PA-phosphatase related
HIN88_18470	COG0861	Integral membrane protein TerC family
HIN88_18480	COG0754	glutathionylspermidine amidase activity
HIN88_18490	COG0402	S-adenosylhomocysteine deaminase activity
HIN88_18505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HIN88_18510	COG1230	cation diffusion facilitator family transporter
HIN88_18525	COG0706	membrane insertase activity
HIN88_18560	COG1373	ATPase (AAA superfamily
HIN88_18645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HIN88_18660	COG3657	addiction module killer protein
HIN88_18665	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HIN88_18690	COG3173	Aminoglycoside phosphotransferase
HIN88_18815	COG0551	DNA topoisomerase type I activity
HIN88_18815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HIN88_18825	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HIN88_18845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HIN88_18850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HIN88_18870	COG2369	cell adhesion
HIN88_18875	COG0582	viral genome integration into host DNA
HIN88_18915	COG1192	Involved in chromosome partitioning