locus-tag class description CTZ18_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CTZ18_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CTZ18_00030 ENOG4105DQR SNARE associated Golgi CTZ18_00035 ENOG4105C5H ABC transporter CTZ18_00040 ENOG4108821 RND type efflux pump CTZ18_00045 ENOG4108821 RND type efflux pump CTZ18_00050 ENOG4108821 RND type efflux pump CTZ18_00060 ENOG4105D74 hydrolase CTZ18_00065 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CTZ18_00070 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CTZ18_00115 ENOG4105C8J )-transporter CTZ18_00125 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CTZ18_00155 ENOG4105C2W permease CTZ18_00165 ENOG4108IG5 Transcriptional regulator CTZ18_00170 ENOG4105DJY efflux transporter, rnd family, mfp subunit CTZ18_00205 ENOG4105F27 Major Facilitator CTZ18_00210 ENOG4105CV8 reductase CTZ18_00215 ENOG4105HEI LysR family (Transcriptional regulator CTZ18_00235 ENOG4105DQ4 alcohol dehydrogenase CTZ18_00240 ENOG4108R3E Dna-3-methyladenine glycosylase i CTZ18_00255 ENOG4105CEN a g-specific adenine glycosylase CTZ18_00275 ENOG4108ZZ3 UPF0260 protein CTZ18_00285 ENOG4105D1H recombination factor protein RarA CTZ18_00290 ENOG4105S64 Formate nitrite transporter CTZ18_00310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CTZ18_00315 ENOG4108RWI nicotinamidase CTZ18_00320 ENOG4105C09 Bile acid CTZ18_00325 ENOG4107QI1 Mate efflux family protein CTZ18_00330 ENOG4105EWC Purine nucleoside phosphorylase CTZ18_00350 ENOG4108RXX maleylacetoacetate isomerase CTZ18_00360 ENOG4105C85 amino acid CTZ18_00370 ENOG4105CKI cobalamin synthesis protein CTZ18_00380 ENOG4105CZE histidine utilization repressor CTZ18_00385 ENOG41090B9 response to stress CTZ18_00400 ENOG4105C85 amino acid CTZ18_00410 ENOG41088SP formiminoglutamate hydrolase CTZ18_00430 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CTZ18_00435 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CTZ18_00445 ENOG4108ZAI phosphatidylglycerophosphatase a CTZ18_00450 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CTZ18_00465 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CTZ18_00505 ENOG4105KHC sulfurtransferase CTZ18_00535 ENOG4105BZU Histidine kinase CTZ18_00540 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CTZ18_00555 ENOG4107QJQ Mate efflux family protein CTZ18_00560 ENOG4105CHM Aminotransferase CTZ18_00565 ENOG4106BRA Membrane CTZ18_00580 ENOG4105D9M gamma-glutamylcysteine synthetase CTZ18_00590 ENOG4105CS6 Rhs element vgr protein CTZ18_00615 ENOG4105IPS esterase CTZ18_00620 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CTZ18_00625 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CTZ18_00630 ENOG4108Z2U ureidoglycolate hydrolase CTZ18_00640 ENOG41061H0 Monooxygenase CTZ18_00655 ENOG41084YZ Hydrolase CTZ18_00685 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) CTZ18_00690 ENOG4105BZU Histidine kinase CTZ18_00705 ENOG4105KUZ arsenate reductase CTZ18_00710 ENOG4105CGK Exodeoxyribonuclease III CTZ18_00730 ENOG4105D7Z glutathione synthase CTZ18_00750 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) CTZ18_00755 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CTZ18_00760 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CTZ18_00775 ENOG41063SB peptidase CTZ18_00780 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CTZ18_00785 ENOG4107QSN dihydrolipoamide acetyltransferase CTZ18_00800 ENOG4105E0K tonB-dependent siderophore receptor CTZ18_00815 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CTZ18_00830 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CTZ18_00850 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CTZ18_00855 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase CTZ18_00865 ENOG4105D64 Mechanosensitive ion channel CTZ18_00875 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CTZ18_00880 ENOG4108W2Y isochorismatase CTZ18_00890 ENOG4105D5G Transposase CTZ18_00895 ENOG4105FBW Monooxygenase CTZ18_00900 ENOG4108UZX fmn reductase CTZ18_00915 ENOG4105BZU Histidine kinase CTZ18_00920 ENOG41062QD Membrane CTZ18_00925 ENOG4107QN1 sodium solute CTZ18_00935 ENOG4105C94 Transporter CTZ18_00945 ENOG4105BZU Histidine kinase CTZ18_00955 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CTZ18_00960 ENOG4108WUH Transcriptional regulator, TetR family CTZ18_00965 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CTZ18_00975 ENOG4105RA2 Membrane CTZ18_00980 ENOG4105DWF phosphomethylpyrimidine kinase CTZ18_00990 ENOG4107RDB Major Facilitator CTZ18_00995 ENOG4108UUM single-stranded DNA-binding protein CTZ18_01005 ENOG4108UMN azlc family CTZ18_01015 ENOG4105C85 amino acid CTZ18_01025 ENOG4108JPW Aminotransferase CTZ18_01030 ENOG4105C26 Dehydrogenase CTZ18_01040 ENOG4105CHJ isochorismatase hydrolase CTZ18_01045 ENOG4105EUB pirin domain protein CTZ18_01070 ENOG4105D94 Major Facilitator Superfamily CTZ18_01075 ENOG4106NZI LysR family Transcriptional regulator CTZ18_01095 ENOG4105CPC Aldo Keto reductase CTZ18_01100 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) CTZ18_01130 ENOG4105KVH Transcriptional regulator CTZ18_01140 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CTZ18_01205 ENOG4105CUV Homoserine Kinase CTZ18_01220 ENOG41061CK Antibiotic biosynthesis monooxygenase CTZ18_01250 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CTZ18_01280 ENOG4105CYC Transferase CTZ18_01290 ENOG4105E0F Histidine kinase CTZ18_01295 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CTZ18_01305 ENOG4105CHH sulfate transporter CTZ18_01310 ENOG4105PDP Short chain dehydrogenase CTZ18_01320 ENOG4105C5H ABC transporter CTZ18_01405 ENOG4108IQI permease CTZ18_01430 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CTZ18_01445 ENOG4105CJN penicillin-binding protein CTZ18_01450 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CTZ18_01455 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) CTZ18_01470 ENOG4105DHI Methyltransferase CTZ18_01475 ENOG4108JQC penicillin-binding protein 1A CTZ18_01500 ENOG4105E4G Type IV pilus CTZ18_01520 ENOG4105CBC glutamate synthase CTZ18_01525 ENOG4105BZ8 glutamate synthase CTZ18_01535 ENOG4108V0P LemA family CTZ18_01540 ENOG4105HA9 of methanol dehydrogenase type CTZ18_01555 ENOG4108YSG O-Antigen polymerase CTZ18_01560 ENOG4108UQY Iron-storage protein CTZ18_01570 ENOG4105KME endoribonuclease L-psp CTZ18_01575 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CTZ18_01585 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CTZ18_01635 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CTZ18_01650 ENOG4107IFA Lipase (EC 3.1.1.3) CTZ18_01655 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) CTZ18_01660 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CTZ18_01685 ENOG4108JQ1 Dehydrogenase CTZ18_01690 ENOG4105CQB FAD linked oxidase domain protein CTZ18_01700 ENOG4105VRH Antibiotic biosynthesis monooxygenase CTZ18_01705 ENOG4105NF4 modulator of drug activity CTZ18_01715 ENOG4107QF7 multi-drug CTZ18_01720 ENOG4105EM2 membrane CTZ18_01725 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CTZ18_01730 ENOG4105IPI Membrane CTZ18_01735 ENOG4107SKI cobyrinic Acid a,c-diamide synthase CTZ18_01765 ENOG4108IQI permease CTZ18_01770 ENOG4105D82 Glutamate dehydrogenase CTZ18_01775 ENOG4105C8Y Acetylornithine aminotransferase CTZ18_01785 ENOG4105C26 Dehydrogenase CTZ18_01870 ENOG4105W87 Cbs domain CTZ18_01875 ENOG41067S9 phage shock protein C, PspC CTZ18_01885 ENOG4105CSU acyl-Coa dehydrogenase CTZ18_01900 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) CTZ18_01915 ENOG4105ECY inositol monophosphatase CTZ18_01920 ENOG4105C1J atp-dependent rna helicase CTZ18_01925 ENOG4105DHJ ABC, transporter CTZ18_01930 ENOG4105CY3 ABC transporter, permease CTZ18_01940 ENOG4105E3I toluene tolerance CTZ18_01950 ENOG4105D7N magnesium and cobalt transport protein CorA CTZ18_01955 ENOG4108URH decarboxylase CTZ18_01965 ENOG4105MJ2 Competence protein CTZ18_01970 ENOG4105CB5 ATP-dependent DNA helicase recG CTZ18_01990 ENOG4105C29 acyl-CoA thioesterase CTZ18_01995 ENOG4105CK2 sodium dicarboxylate symporter CTZ18_02010 ENOG4105KPV Transcriptional regulator CTZ18_02020 ENOG4105D7A ATP-binding protein CTZ18_02025 ENOG4105C28 cystathionine CTZ18_02030 ENOG41089BK Glutamine amido-transferase CTZ18_02140 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CTZ18_02145 ENOG41067V7 50S ribosomal protein L36 CTZ18_02155 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CTZ18_02180 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_02215 ENOG4105VKU nucleicacid-binding protein CTZ18_02220 ENOG4105DGW oligopeptidase A CTZ18_02225 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CTZ18_02270 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CTZ18_02275 ENOG4108K2B transcriptional regulator CTZ18_02285 ENOG4107S2Z UPF0761 membrane protein CTZ18_02290 ENOG4105CS1 NAD(P)H quinone oxidoreductase CTZ18_02320 ENOG4105C9A Phoh family CTZ18_02330 ENOG4105E4C Lytic transglycosylase catalytic CTZ18_02360 ENOG4105D6S protein involved in catabolism of external DNA CTZ18_02365 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CTZ18_02410 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_02415 ENOG4108RZE Tetr family transcriptional regulator CTZ18_02430 ENOG4107QX3 carboxylase CTZ18_02435 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_02455 ENOG4105KB2 stringent starvation protein b CTZ18_02460 ENOG4107MKT Stringent starvation protein a CTZ18_02465 ENOG4108UJD 30S ribosomal protein S9 CTZ18_02475 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CTZ18_02480 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CTZ18_02485 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) CTZ18_02505 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CTZ18_02515 ENOG4107RZC phospholipase d CTZ18_02525 ENOG4105UYK outer membrane protein a CTZ18_02530 ENOG4108KHX Diguanylate cyclase CTZ18_02565 ENOG4107QN2 dihydrolipoyl dehydrogenase CTZ18_02575 ENOG4107QPB Beta-lactamase domain protein CTZ18_02580 ENOG4107U2T alpha beta CTZ18_02590 ENOG4105NAU thioesterase Superfamily protein CTZ18_02620 ENOG4105K9H YciI-like protein CTZ18_02630 ENOG4105DB7 PHP domain protein CTZ18_02635 ENOG4105FFC UPF0187 protein CTZ18_02645 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CTZ18_02650 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CTZ18_02655 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CTZ18_02660 ENOG4105VIE preprotein translocase, subunit YajC CTZ18_02725 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CTZ18_02730 ENOG4105CM2 brancheD-chain amino acid aminotransferase CTZ18_02755 ENOG4107BJW polysaccharide deacetylase CTZ18_02765 ENOG4108PQP glycosyl transferase group 1 CTZ18_02805 ENOG4105UGU tonB-dependent Receptor CTZ18_02825 ENOG4108VY7 phosphate-starvation-inducible protein PsiE CTZ18_02830 ENOG4108K3A Glutathione S-transferase CTZ18_02835 ENOG4108R4R Iron-regulated virulence regulatory protein CTZ18_02840 ENOG4105CSU acyl-Coa dehydrogenase CTZ18_02845 ENOG4105CSU acyl-Coa dehydrogenase CTZ18_02855 ENOG4105EB3 Histidine kinase CTZ18_02860 ENOG4105E3W Two component transcriptional regulator (Winged helix family CTZ18_02865 ENOG4105CNG UPF0061 protein CTZ18_02885 ENOG4108WBT adenosyltransferase CTZ18_02900 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CTZ18_02935 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CTZ18_02955 ENOG4105D3R alkyl hydroperoxide reductase CTZ18_02970 ENOG4105CSH Transporter CTZ18_02975 ENOG4108UT2 hemolysin iii CTZ18_03005 ENOG4105CHU acetyl-coa acetyltransferase CTZ18_03010 ENOG4108R6W Transcriptional regulator, ARAC family CTZ18_03020 ENOG4105TW1 Carbohydrate-selective porin OprB CTZ18_03025 ENOG4105DZG Dehydrogenase CTZ18_03030 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CTZ18_03050 ENOG4105CHU acetyl-coa acetyltransferase CTZ18_03060 ENOG4108WHA ompa motb domain protein CTZ18_03070 ENOG4105E0Y RtcB Protein CTZ18_03075 ENOG4108IQI permease CTZ18_03085 ENOG4105C2W permease CTZ18_03105 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CTZ18_03115 ENOG4108VX5 3-methyladenine DNA glycosylase CTZ18_03120 ENOG4105CHB tonB-dependent Receptor CTZ18_03125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CTZ18_03140 ENOG4105T95 Thiol disulfide interChange protein CTZ18_03145 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CTZ18_03155 ENOG4105K78 MarR family Transcriptional regulator CTZ18_03160 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CTZ18_03165 ENOG4105KWI UPF0339 protein CTZ18_03190 ENOG4108UNF response regulator CTZ18_03195 ENOG4105M3Z response regulator CTZ18_03200 ENOG4108ZGA chew protein CTZ18_03205 ENOG4105C8Q Methyl-accepting chemotaxis CTZ18_03210 ENOG4105CBS Chea signal transduction histidine kinase CTZ18_03225 ENOG4106HKS Entericidin EcnA/B family CTZ18_03235 ENOG4105WD1 Membrane CTZ18_03240 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein CTZ18_03280 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CTZ18_03290 ENOG4105EM2 membrane CTZ18_03295 ENOG4105C2C drug resistance transporter, Bcr CflA CTZ18_03315 ENOG4105BZG amino acid carrier protein CTZ18_03320 ENOG4105D78 K07001 NTE family protein CTZ18_03325 ENOG4105C7B Threonine dehydratase CTZ18_03360 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CTZ18_03370 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CTZ18_03375 ENOG4105DFF Rod shape-determining protein mreb CTZ18_03380 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CTZ18_03385 ENOG4105VQ7 Rod shape-determining protein MreD CTZ18_03390 ENOG4108Z03 MAF-like protein CTZ18_03395 ENOG4105C03 ribonuclease CTZ18_03405 ENOG4105D8T Acyltransferase CTZ18_03415 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein CTZ18_03425 ENOG4108X0B nad(p)h dehydrogenase (quinone) CTZ18_03450 ENOG4105CF7 AraC family transcriptional regulator CTZ18_03470 ENOG4105C85 amino acid CTZ18_03475 ENOG4105C7F AcnD-accessory protein PrpF CTZ18_03480 ENOG4105CTB Polyprenyl synthetase CTZ18_03485 ENOG4105MSB protein, conserved in bacteria CTZ18_03500 ENOG4105D78 K07001 NTE family protein CTZ18_03525 ENOG4105DIJ Phosphoethanolamine transferase CTZ18_03530 ENOG4105XJC Two component transcriptional regulator (Winged helix family CTZ18_03535 ENOG4105DHQ Histidine kinase CTZ18_03555 ENOG4108M0I Transcriptional regulator CTZ18_03575 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CTZ18_03595 ENOG4105K8R UPF0145 protein CTZ18_03600 ENOG4105K8R UPF0145 protein CTZ18_03605 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CTZ18_03610 ENOG4105BZS acriflavin resistance protein CTZ18_03615 ENOG4105C1P efflux transporter, rnd family, mfp subunit CTZ18_03620 ENOG410841Q phosphoesterase PA-phosphatase related protein CTZ18_03650 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) CTZ18_03665 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CTZ18_03670 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CTZ18_03675 ENOG4105KVH Transcriptional regulator CTZ18_03685 ENOG4105CUB amino acid CTZ18_03700 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CTZ18_03705 ENOG41084BA UPF0250 protein CTZ18_03710 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CTZ18_03745 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit CTZ18_03750 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein CTZ18_03760 ENOG4105E33 succinate dehydrogenase CTZ18_03775 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CTZ18_03780 ENOG4105C7S Dehydrogenase CTZ18_03785 ENOG4107QN2 dihydrolipoyl dehydrogenase CTZ18_03795 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CTZ18_03805 ENOG4105CKW Inner membrane protein yedI CTZ18_03810 ENOG4105CGZ zinc metallopeptidase CTZ18_03815 ENOG4105EEQ Na H antiporter CTZ18_03840 ENOG4105PNM synthesis protein CTZ18_03855 ENOG41080TK Universal stress protein CTZ18_03870 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CTZ18_03875 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CTZ18_03895 ENOG4105HBR Rna-binding protein CTZ18_03905 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CTZ18_03910 ENOG4105EEI dihydropteroate synthase CTZ18_03960 ENOG4105CSH Transporter CTZ18_03965 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CTZ18_03970 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CTZ18_03985 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CTZ18_04005 ENOG41080IJ Diacylglycerol kinase CTZ18_04015 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CTZ18_04020 ENOG4105BZS acriflavin resistance protein CTZ18_04035 ENOG4105E4C Lytic transglycosylase catalytic CTZ18_04060 ENOG4108RRZ Transcription elongation factor GreB CTZ18_04075 ENOG4105CEY Amp-dependent synthetase and ligase CTZ18_04115 ENOG4105BZW Glycerate kinase CTZ18_04120 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit CTZ18_04125 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CTZ18_04140 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) CTZ18_04150 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CTZ18_04155 ENOG4105C85 amino acid CTZ18_04165 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CTZ18_04175 ENOG4105N14 lysine exporter protein LysE YggA CTZ18_04180 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CTZ18_04185 ENOG4105BZJ Electron transfer flavoprotein CTZ18_04190 ENOG4105C10 Electron transfer flavoprotein CTZ18_04195 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CTZ18_04230 ENOG4107KET secretion protein, HlyD family CTZ18_04260 ENOG4105D60 lipoprotein releasing system transmembrane protein CTZ18_04265 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CTZ18_04270 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CTZ18_04280 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CTZ18_04285 ENOG4107R6F Alpha Beta Hydrolase Fold protein CTZ18_04290 ENOG4108V3E phosphoribosylglycinamide formyltransferase CTZ18_04300 ENOG4105C02 permease CTZ18_04350 ENOG4105KCK Peptidoglycan-associated lipoprotein CTZ18_04355 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) CTZ18_04365 ENOG4105M8F Biopolymer transport protein exbD tolR CTZ18_04370 ENOG4105E02 MotA TolQ exbB proton channel CTZ18_04375 ENOG4107YD3 Thioesterase CTZ18_04380 ENOG4105CH2 amidohydrolase CTZ18_04400 ENOG4108ETH Formylglycinamide ribotide synthetase CTZ18_04405 ENOG4105C2C drug resistance transporter, Bcr CflA CTZ18_04410 ENOG4105EGD dinuclear metal center protein, YbgI family CTZ18_04415 ENOG4108UKI Enoyl-CoA hydratase CTZ18_04430 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CTZ18_04445 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CTZ18_04450 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CTZ18_04465 ENOG4107R11 Transcriptional regulator CTZ18_04470 ENOG4108IJ6 ABC transporter CTZ18_04480 ENOG4108I5D sulfate abc transporter CTZ18_04490 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CTZ18_04495 ENOG4105YAZ 4-amino-4-deoxychorismate lyase CTZ18_04500 ENOG4105HHA aminodeoxychorismate lyase CTZ18_04515 ENOG4108IYU L-aspartate oxidase CTZ18_04520 ENOG4105C0H protease CTZ18_04535 ENOG4105C3F Signal peptidase i CTZ18_04550 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CTZ18_04560 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) CTZ18_04565 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) CTZ18_04570 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase CTZ18_04575 ENOG4105EMU Dehydrogenase CTZ18_04615 ENOG4105BZU Histidine kinase CTZ18_04625 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CTZ18_04635 ENOG4105DTR rard protein CTZ18_04670 ENOG4107QS8 (LipO)protein CTZ18_04675 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CTZ18_04680 ENOG4105EA8 2-Nitropropane dioxygenase CTZ18_04710 ENOG4107R8N Glycosyl transferase, family 2 CTZ18_04725 ENOG4105CVP deoxyribo-dipyrimidine photolyase CTZ18_04730 ENOG4108YZY peptidylprolyl cis-trans isomerase CTZ18_04735 ENOG4105CEP NADH dehydrogenase CTZ18_04740 ENOG4105DZ1 carboxypeptidase CTZ18_04750 ENOG4105E9K Isocitrate dehydrogenase CTZ18_04755 ENOG4108R99 pseudouridine synthase CTZ18_04780 ENOG4105CBP Major Facilitator CTZ18_04785 ENOG4105EGI Transcriptional regulator CTZ18_04790 ENOG4108ETY sodium dicarboxylate symporter CTZ18_04795 ENOG4105JAB phenazine biosynthesis protein, phzf family CTZ18_04825 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CTZ18_04840 ENOG4105D3G Pseudouridine synthase CTZ18_04845 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) CTZ18_04860 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CTZ18_04885 ENOG4108JPW Aminotransferase CTZ18_04890 ENOG4105DY8 decarboxylase CTZ18_04900 ENOG4105F7P transcriptional regulator AsnC family CTZ18_04905 ENOG4107RA9 decarboxylase CTZ18_04910 ENOG4105C85 amino acid CTZ18_04915 ENOG4105CVA phosphate CTZ18_04920 ENOG4105C8U phosphate abc transporter CTZ18_04930 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CTZ18_04935 ENOG4105ERU peptidase CTZ18_04950 ENOG4107QTF adenylosuccinate lyase CTZ18_04970 ENOG4108Z0R Transferase CTZ18_04975 ENOG4105DZ1 carboxypeptidase CTZ18_04995 ENOG4108K5P (LipO)protein CTZ18_05000 ENOG4105EJC lysr family transcriptional regulator CTZ18_05005 ENOG4105DAN ATP-dependent protease CTZ18_05020 ENOG4105DHU Bile acid CTZ18_05040 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CTZ18_05050 ENOG4105D22 carbon starvation protein CTZ18_05055 ENOG4105VCD cytoplasmic protein CTZ18_05090 ENOG4108K8K Transcriptional regulator CTZ18_05105 ENOG4105C26 Dehydrogenase CTZ18_05110 ENOG4105C85 amino acid CTZ18_05115 ENOG4105ETT transcriptional Regulator, LysR family CTZ18_05120 ENOG4105C94 Transporter CTZ18_05125 ENOG4105C94 Transporter CTZ18_05135 ENOG4105C26 Dehydrogenase CTZ18_05140 ENOG4107QZF nitrite reductase NADPH large subunit CTZ18_05145 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) CTZ18_05175 ENOG41060M8 Pfam:PhdYeFM CTZ18_05180 ENOG4107QNK )-transporter CTZ18_05185 ENOG4107WEA mandelate racemase muconate lactonizing CTZ18_05195 ENOG4105J7D transcriptional regulator CTZ18_05215 ENOG4105C2I pirin domain protein CTZ18_05225 ENOG4105WWK YheO domain protein CTZ18_05240 ENOG4105CEY Amp-dependent synthetase and ligase CTZ18_05255 ENOG4108IPW abc transporter atp-binding protein CTZ18_05275 ENOG4105C0W non-ribosomal peptide synthetase CTZ18_05280 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CTZ18_05285 ENOG4105WQI isochorismatase CTZ18_05300 ENOG4105BZ1 (ABC) transporter CTZ18_05320 ENOG4105E4F Isochorismate synthase CTZ18_05335 ENOG4105NX3 Membrane CTZ18_05355 ENOG4105EUJ GTP cyclohydrolase i CTZ18_05365 ENOG4105C7W Xanthine dehydrogenase CTZ18_05395 ENOG4105CD8 aminopeptidase N CTZ18_05400 ENOG4105DDQ anthranilate synthase CTZ18_05410 ENOG4105DUX Transporter CTZ18_05415 ENOG4105C5F glutamine synthetase CTZ18_05425 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) CTZ18_05460 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CTZ18_05465 ENOG4107QNR UPF0135 protein CTZ18_05470 ENOG4105C0H protease CTZ18_05480 ENOG4105C6K Malic enzyme CTZ18_05485 ENOG4105BZU Histidine kinase CTZ18_05490 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CTZ18_05495 ENOG4105SYT Methylenetetrahydrofolate reductase CTZ18_05500 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CTZ18_05515 ENOG4107QPN acyl-Coa dehydrogenase CTZ18_05520 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CTZ18_05525 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CTZ18_05535 ENOG4107RNU major facilitator superfamily MFS_1 CTZ18_05545 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CTZ18_05550 ENOG4105CE9 30S ribosomal protein S2 CTZ18_05590 ENOG4105CVE Lytic murein transglycosylase CTZ18_05595 ENOG4105CNI cell division protein FtsW CTZ18_05610 ENOG4105E3A (ABC) transporter CTZ18_05615 ENOG4105DA5 (ABC) transporter CTZ18_05650 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CTZ18_05660 ENOG4105ENT Efflux transporter rnd family, mfp subunit CTZ18_05685 ENOG4105DSP amino acid AbC transporter CTZ18_05690 ENOG4106YG3 ABC transporter CTZ18_05695 ENOG4108JEH abc transporter atp-binding protein CTZ18_05705 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CTZ18_05710 ENOG4105CFP Peptidase U32 CTZ18_05715 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CTZ18_05720 ENOG4105JAB phenazine biosynthesis protein, phzf family CTZ18_05725 ENOG4105DP0 ferredoxin-NADP reductase CTZ18_05730 ENOG4108R96 Methyltransferase, YaeB family CTZ18_05740 ENOG4107QHF type ii secretion system protein e CTZ18_05750 ENOG4105XJC Two component transcriptional regulator (Winged helix family CTZ18_05755 ENOG4105DHQ Histidine kinase CTZ18_05765 ENOG4105M6F mutator MutT protein CTZ18_05775 ENOG4105BZ4 penicillin-binding protein CTZ18_05780 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CTZ18_05785 ENOG4105VUT cytoplasmic protein CTZ18_05790 ENOG4107QYG anthranilate phosphoribosyltransferase CTZ18_05800 ENOG4105CK2 sodium dicarboxylate symporter CTZ18_05805 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_05810 ENOG4105NIV Esterase CTZ18_05815 ENOG4105CQC Prephenate dehydratase CTZ18_05820 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CTZ18_05830 ENOG4105CIN aminoacyl-histidine dipeptidase CTZ18_05835 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CTZ18_05865 ENOG4105M08 Membrane CTZ18_05870 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CTZ18_05880 ENOG4105VEQ Cold shock protein CTZ18_05885 ENOG4105C1J atp-dependent rna helicase CTZ18_05895 ENOG41069NU Nitroreductase CTZ18_06210 ENOG4105DR5 peptidase CTZ18_06285 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase CTZ18_06300 ENOG4105C5I Dehydrogenase CTZ18_06305 ENOG4105ERG peptidase m48, ste24p CTZ18_06310 ENOG4105KTH gatB Yqey CTZ18_06315 ENOG4105VCC 30S ribosomal protein S21 CTZ18_06340 ENOG4105D9P serine threonine protein kinase CTZ18_06365 ENOG4105EVZ LysR family transcriptional regulator CTZ18_06370 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CTZ18_06375 ENOG4105C26 Dehydrogenase CTZ18_06410 ENOG4105H4F exported protein CTZ18_06440 ENOG4105D6U Sodium Glutamate Symporter CTZ18_06450 ENOG4105JXH GntR family transcriptional regulator CTZ18_06500 ENOG4105CSH Transporter CTZ18_06525 ENOG4105CEB Aspartate aminotransferase CTZ18_06540 ENOG4105F1S paraquat-inducible protein a CTZ18_06545 ENOG4105DY2 Paraquat-inducible protein b CTZ18_06585 ENOG4105CK2 sodium dicarboxylate symporter CTZ18_06595 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CTZ18_06600 ENOG4108UMI ABC transporter, permease CTZ18_06605 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CTZ18_06615 ENOG4105C12 Phosphoribosylglycinamide synthetase CTZ18_06620 ENOG4105DC1 bifunctional purine biosynthesis protein purh CTZ18_06625 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) CTZ18_06675 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CTZ18_06680 ENOG4105CDU Replicative dna helicase CTZ18_06705 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) CTZ18_06710 ENOG4105CCU oxidase (Subunit III) CTZ18_06715 ENOG4105BZ9 Cytochrome C oxidase, subunit I CTZ18_06720 ENOG4105E2S oxidase) subunit II CTZ18_06745 ENOG4107BJW polysaccharide deacetylase CTZ18_06750 ENOG4105CND Glycosyl transferase, family 2 CTZ18_06755 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD CTZ18_06765 ENOG4105DEN Luciferase family CTZ18_06785 ENOG4105CC0 LysR family Transcriptional regulator CTZ18_06800 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CTZ18_06805 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CTZ18_06810 ENOG4105GVF (ABC) transporter CTZ18_06825 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_06835 ENOG4108MEJ flavin reductase domain protein CTZ18_06840 ENOG4105D06 uba thif-type nad fad binding protein CTZ18_06860 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CTZ18_06865 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CTZ18_06875 ENOG4105C08 Histidine kinase CTZ18_06880 ENOG4105EEX Two component transcriptional regulator (Winged helix family CTZ18_06885 ENOG4105CFQ glutamine synthetase CTZ18_06900 ENOG4107S74 Lysophospholipid transporter LplT CTZ18_06905 ENOG4105CFU surface antigen CTZ18_06925 ENOG4107QIJ Aconitate hydratase 2 CTZ18_06935 ENOG4105EYW Ion transport protein CTZ18_06940 ENOG4105F27 Major Facilitator CTZ18_06955 ENOG4105DZ2 Transcriptional regulator CTZ18_06990 ENOG4105K8N protein family UPF0079, ATPase CTZ18_06995 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CTZ18_07005 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CTZ18_07010 ENOG4108TZV Membrane CTZ18_07015 ENOG4108RCM Nitroreductase CTZ18_07025 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) CTZ18_07040 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CTZ18_07045 ENOG4107FQ9 ethanolamine ammonia-lyase CTZ18_07050 ENOG4105CPD ethanolamine ammonia-lyase CTZ18_07055 ENOG4107R55 ethanolamine transporter CTZ18_07065 ENOG4107RR1 TRANSCRIPTIONal CTZ18_07075 ENOG4105C0A alcohol dehydrogenase CTZ18_07080 ENOG4107QUV Domain protein CTZ18_07090 ENOG4105F4I Transcriptional regulator CTZ18_07110 ENOG4105CD8 aminopeptidase N CTZ18_07120 ENOG4105EMU Dehydrogenase CTZ18_07130 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) CTZ18_07135 ENOG4105EW9 transcriptional regulator AsnC family CTZ18_07150 ENOG4105R8C Transcriptional regulator CTZ18_07160 ENOG4105CUY Mechanosensitive ion channel CTZ18_07190 ENOG4105CNM Receptor CTZ18_07210 ENOG4105C5H ABC transporter CTZ18_07215 ENOG41081QV Universal stress protein CTZ18_07235 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CTZ18_07245 ENOG4105DKK Benzoate CTZ18_07250 ENOG4105EW9 transcriptional regulator AsnC family CTZ18_07255 ENOG4108NIW Leucine export protein LeuE CTZ18_07260 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CTZ18_07265 ENOG4105C5Q Transcriptional regulator CTZ18_07275 ENOG4105CHU acetyl-coa acetyltransferase CTZ18_07280 ENOG4105CHR reductase CTZ18_07305 ENOG4107QMP dna polymerase iii subunits gamma and tau CTZ18_07310 ENOG4105HSS phospholipase C CTZ18_07320 ENOG4105C0A alcohol dehydrogenase CTZ18_07350 ENOG4105CBC glutamate synthase CTZ18_07725 ENOG4105D8G Major Facilitator superfamily CTZ18_07735 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CTZ18_07740 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein CTZ18_07760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CTZ18_07770 ENOG4107QZF nitrite reductase NADPH large subunit CTZ18_07775 ENOG4108IFG nitrite reductase, (NAD(P)H) CTZ18_07795 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CTZ18_07810 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CTZ18_07815 ENOG4105CVM Molybdenum cofactor synthesis domain protein CTZ18_07825 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CTZ18_07830 ENOG4105T38 integral membrane protein CTZ18_07850 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) CTZ18_07855 ENOG4105CMR udp-glucose 4-epimerase CTZ18_07915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CTZ18_07920 ENOG4105CUX Signal transduction histidine kinase CTZ18_07940 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CTZ18_07945 ENOG4105KNE Phosphatidate cytidylyltransferase CTZ18_07955 ENOG4105DZP Membrane-associated zinc metalloprotease CTZ18_07980 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CTZ18_07995 ENOG4105Y3E Modulates RecA activity (By similarity) CTZ18_08005 ENOG4105VEJ Heat shock protein CTZ18_08010 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 CTZ18_08035 ENOG4105F7P transcriptional regulator AsnC family CTZ18_08045 ENOG4105C85 amino acid CTZ18_08065 ENOG4105CHH sulfate transporter CTZ18_08110 ENOG4105BZ1 (ABC) transporter CTZ18_08165 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CTZ18_08250 ENOG4105CWM branched-chain amino acid transport system II carrier protein CTZ18_08255 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CTZ18_08260 ENOG4105CC0 LysR family Transcriptional regulator CTZ18_08270 ENOG4105M2J Glutaredoxin CTZ18_08275 ENOG4105C8Y Acetylornithine aminotransferase CTZ18_08280 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CTZ18_08305 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CTZ18_08315 ENOG41068P6 UPF0319 protein CTZ18_08335 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CTZ18_08340 ENOG4105C4M (Ubiquinol oxidase) subunit I CTZ18_08350 ENOG4105PV3 Inner membrane protein yqiJ CTZ18_08365 ENOG4105E0K tonB-dependent siderophore receptor CTZ18_08375 ENOG4105HDD phospholipase CTZ18_08380 ENOG4105CZN Potassium uptake protein CTZ18_08390 ENOG4105C7B Threonine dehydratase CTZ18_08420 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CTZ18_08425 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CTZ18_08435 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CTZ18_08450 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CTZ18_08495 ENOG4107VMU Membrane CTZ18_08500 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) CTZ18_08510 ENOG4107QP7 CoA-transferase subunit A CTZ18_08515 ENOG4107QNJ CoA-transferase subunit B CTZ18_08520 ENOG4105CHU acetyl-coa acetyltransferase CTZ18_08525 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase CTZ18_08530 ENOG4105F2Z 3-oxoadipate enol-lactonase CTZ18_08535 ENOG4105D2S major facilitator superfamily CTZ18_08540 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CTZ18_08545 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta CTZ18_08550 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha CTZ18_08555 ENOG4105FF2 Type I DHQase CTZ18_08560 ENOG4106JPM 3-dehydroshikimate dehydratase CTZ18_08565 ENOG4105TW1 Carbohydrate-selective porin OprB CTZ18_08570 ENOG4105DZG Dehydrogenase CTZ18_08580 ENOG4105MD1 YeeE YedE family protein CTZ18_08595 ENOG4107HP6 Transcriptional regulator CTZ18_08600 ENOG4108PTX LysR family Transcriptional regulator CTZ18_08605 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_08630 ENOG4105DNH Major Facilitator CTZ18_08640 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CTZ18_08660 ENOG4105FUY alpha subunit CTZ18_08670 ENOG4105CHR reductase CTZ18_08690 ENOG4105F11 amine oxidase CTZ18_08700 ENOG4105C26 Dehydrogenase CTZ18_08710 ENOG4105F2Z 3-oxoadipate enol-lactonase CTZ18_08715 ENOG4105CHU acetyl-coa acetyltransferase CTZ18_08720 ENOG4107QNJ CoA-transferase subunit B CTZ18_08725 ENOG4107QP7 CoA-transferase subunit A CTZ18_08735 ENOG4105NN7 muconolactone delta-isomerase CTZ18_08740 ENOG4105DTQ mandelate racemase muconate lactonizing CTZ18_08745 ENOG4108KB2 LysR family Transcriptional regulator CTZ18_08755 ENOG4107EJG GntR family transcriptional regulator CTZ18_08775 ENOG4105CZJ Aldehyde dehydrogenase CTZ18_08795 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_08800 ENOG4105CHR reductase CTZ18_08805 ENOG4108JU7 Transcriptional regulator CTZ18_08815 ENOG41062QD Membrane CTZ18_08830 ENOG4107RGH Aldehyde dehydrogenase CTZ18_08845 ENOG4105CH6 catalase CTZ18_08870 ENOG4105K56 Transcriptional regulator CTZ18_08875 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CTZ18_08885 ENOG4105NAE bifunctional deaminase-reductase domain protein CTZ18_08915 ENOG4107Z3H Transcriptional regulator, TetR family CTZ18_08925 ENOG4105CHJ isochorismatase hydrolase CTZ18_08930 ENOG4105EJC lysr family transcriptional regulator CTZ18_08935 ENOG4105D8V Glucose sorbosone dehydrogenase CTZ18_08940 ENOG4105CKD glutathione-regulated potassium-efflux system protein CTZ18_08950 ENOG4105CH2 amidohydrolase CTZ18_08965 ENOG4105D5K Hemolysin activator protein CTZ18_08970 ENOG4105CKT filamentous hemagglutinin CTZ18_09000 ENOG4105FDP GntR family transcriptional regulator CTZ18_09015 ENOG4106KR7 LysR family Transcriptional regulator CTZ18_09040 ENOG4108JQ1 Dehydrogenase CTZ18_09045 ENOG4105JSC dimethylmenaquinone methyltransferase CTZ18_09065 ENOG4105CW7 secretion protein, HlyD family CTZ18_09080 ENOG4105CZJ Aldehyde dehydrogenase CTZ18_09085 ENOG4105C01 Dihydroxy-acid dehydratase CTZ18_09095 ENOG4105DDW LysR family Transcriptional regulator CTZ18_09100 ENOG4105EXW epimerase dehydratase CTZ18_09110 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CTZ18_09115 ENOG4105CF7 AraC family transcriptional regulator CTZ18_09130 ENOG4105DQ4 alcohol dehydrogenase CTZ18_09140 ENOG4105EHG Permease protein CTZ18_09145 ENOG4105E0A ABC, transporter CTZ18_09165 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CTZ18_09245 ENOG4108UAJ Transcriptional regulator CTZ18_09285 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CTZ18_09335 ENOG4108BAS reductase CTZ18_09350 ENOG4108R6W Transcriptional regulator, ARAC family CTZ18_09355 ENOG4108821 RND type efflux pump CTZ18_09360 ENOG4105E0F Histidine kinase CTZ18_09365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CTZ18_09370 ENOG4105C1P efflux transporter, rnd family, mfp subunit CTZ18_09375 ENOG4105BZS acriflavin resistance protein CTZ18_09380 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CTZ18_09390 ENOG4105CT3 Monooxygenase CTZ18_09410 ENOG4105CJP fad dependent oxidoreductase CTZ18_09430 ENOG4105X0I Fimbrial CTZ18_09485 ENOG4107RZC phospholipase d CTZ18_09505 ENOG4108IGT Dipeptidase CTZ18_09540 ENOG4107T31 5'-nucleotidase CTZ18_09550 ENOG4105WQI isochorismatase CTZ18_09555 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CTZ18_09560 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CTZ18_09565 ENOG4105E0C molybdate abc transporter CTZ18_09570 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CTZ18_09575 ENOG4105F4R Transcriptional regulator mode CTZ18_09580 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit CTZ18_09585 ENOG4108YS2 small subunit CTZ18_09590 ENOG4105F57 Anthranilate dioxygenase reductase CTZ18_09615 ENOG4105CHR reductase CTZ18_09625 ENOG4105D2S major facilitator superfamily CTZ18_09630 ENOG4105CF7 AraC family transcriptional regulator CTZ18_09640 ENOG4105DTD Dehydrogenase CTZ18_09645 ENOG4105CY2 Citrate transporter CTZ18_09655 ENOG4108M0I Transcriptional regulator CTZ18_09665 ENOG4107QNJ CoA-transferase subunit B CTZ18_09670 ENOG4105CRW Short chain fatty acid transporter CTZ18_09675 ENOG4105CHU acetyl-coa acetyltransferase CTZ18_09685 ENOG4107YNJ LysR family Transcriptional regulator CTZ18_09700 ENOG4108IJ0 Aspartate ammonia-lyase CTZ18_09710 ENOG4105CSH Transporter CTZ18_09730 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CTZ18_09735 ENOG4106FTQ Taurine ABC transporter, periplasmic CTZ18_09750 ENOG4105FDP GntR family transcriptional regulator CTZ18_09760 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CTZ18_09765 ENOG4105KVH Transcriptional regulator CTZ18_09770 ENOG4105UEI Transcriptional Regulator AraC Family CTZ18_09785 ENOG4108VCT Sulfite exporter TauE/SafE CTZ18_09795 ENOG4107QPB Beta-lactamase domain protein CTZ18_09805 ENOG4105FFC UPF0187 protein CTZ18_09815 ENOG4105CHR reductase CTZ18_09830 ENOG4105CPP Dehydrogenase, E1 component CTZ18_09835 ENOG4107R0V Pyruvate dehydrogenase CTZ18_09840 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CTZ18_09855 ENOG4105BZU Histidine kinase CTZ18_09865 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CTZ18_09870 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CTZ18_09915 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CTZ18_09930 ENOG4105C28 cystathionine CTZ18_09940 ENOG4105F2W methyltransferase CTZ18_09970 ENOG4105K59 histidine triad (HIT) protein CTZ18_09995 ENOG4107QWP ABC-2 type transporter CTZ18_10000 ENOG4107QWP ABC-2 type transporter CTZ18_10005 ENOG4105CJ1 ABC, transporter CTZ18_10020 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) CTZ18_10025 ENOG4105CNM Receptor CTZ18_10045 ENOG4107TSN permease CTZ18_10050 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CTZ18_10070 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CTZ18_10075 ENOG4108YZT Adenosylcobinamide kinase CTZ18_10125 ENOG4105DJU Siderophore biosynthesis protein CTZ18_10130 ENOG4105DUU IucA IucC family protein CTZ18_10150 ENOG4108Z66 YbaK ebsC protein CTZ18_10165 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_10170 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_10175 ENOG4105EEF Alkane 1-monooxygenase CTZ18_10180 ENOG4105E7U AraC family transcriptional regulator CTZ18_10185 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CTZ18_10190 ENOG4105K70 DNA-binding protein CTZ18_10205 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family CTZ18_10215 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins CTZ18_10220 ENOG4108Z4V iron-sulfur cluster assembly CTZ18_10235 ENOG4108ZIT Ferredoxin, 2FE-2S CTZ18_10240 ENOG4105F8J Adenylate Guanylate cyclase CTZ18_10250 ENOG4108JA2 transcriptioN-repair coupling factor CTZ18_10270 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) CTZ18_10275 ENOG4105K4T epimerase CTZ18_10290 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase CTZ18_10310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CTZ18_10320 ENOG4105DGW oligopeptidase A CTZ18_10355 ENOG4105SG9 biopolymer transport protein, ExbD CTZ18_10365 ENOG4107QP3 malate synthase g CTZ18_10370 ENOG4105D6Z AFG1 family ATPase CTZ18_10380 ENOG4107RN6 Monooxygenase CTZ18_10400 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) CTZ18_10405 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CTZ18_10420 ENOG4108Z6B deaminase CTZ18_10440 ENOG4108RTD type II secretion system protein K CTZ18_10465 ENOG4105F8V Hydrolase, tatD family CTZ18_10475 ENOG4107QRG dna polymerase iii CTZ18_10485 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) CTZ18_10490 ENOG4105BZ1 (ABC) transporter CTZ18_10505 ENOG4105FA0 parb-like partition protein CTZ18_10510 ENOG4107QJE Chromosome Partitioning Protein CTZ18_10520 ENOG4108S0S Nucleotidyl transferase CTZ18_10525 ENOG4105EHM Aminoglycoside phosphotransferase CTZ18_10530 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) CTZ18_10535 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) CTZ18_10540 ENOG4105D2N Aldolase CTZ18_10560 ENOG4108UHJ MAF-like protein CTZ18_10565 ENOG4105EZE Cupin 4 family protein CTZ18_10575 ENOG41080HT Transcriptional regulator, arsr family CTZ18_10585 ENOG4105XPP Protein of unknown function (DUF1275) CTZ18_10590 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme CTZ18_10595 ENOG4105BZ1 (ABC) transporter CTZ18_10605 ENOG4108ZX5 transcriptional regulator CTZ18_10615 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CTZ18_10620 ENOG4105CK7 Sodium proline symporter CTZ18_10625 ENOG4105EW9 transcriptional regulator AsnC family CTZ18_10630 ENOG4105C26 Dehydrogenase CTZ18_10635 ENOG4105YGK Pfam:UPF0157 CTZ18_10650 ENOG4108T58 Mg2 transport protein CorA CTZ18_10660 ENOG4108YYC ycei family CTZ18_10670 ENOG4105CV1 Transketolase (EC 2.2.1.1) CTZ18_10695 ENOG4108HWY Beta-lactamase CTZ18_10715 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CTZ18_10720 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CTZ18_10740 ENOG4105X0I Fimbrial CTZ18_10745 ENOG4105GQR Chaperone CTZ18_10775 ENOG4108IPJ Membrane CTZ18_10785 ENOG4105ETS cytosine purines uracil thiamine allantoin CTZ18_10795 ENOG4105CC0 LysR family Transcriptional regulator CTZ18_10815 ENOG41067SE Tetr family transcriptional regulator CTZ18_10830 ENOG4105EW9 transcriptional regulator AsnC family CTZ18_10840 ENOG4105CDA abc transporter atp-binding protein CTZ18_10845 ENOG4105DRP amino acid AbC transporter CTZ18_10850 ENOG4105EAD ABC transporter CTZ18_10865 ENOG4107T8P acyl-Coa dehydrogenase CTZ18_10880 ENOG4105D01 (LipO)protein CTZ18_10885 ENOG4105D01 (LipO)protein CTZ18_10905 ENOG4108UMI ABC transporter, permease CTZ18_10910 ENOG4105C3G gtp-binding protein CTZ18_10935 ENOG4108UMN azlc family CTZ18_10940 ENOG4105ZED uncharacterized protein ygaH CTZ18_10970 ENOG4105E7U AraC family transcriptional regulator CTZ18_10975 ENOG4108V06 Glutathione peroxidase CTZ18_10985 ENOG4105CHM Aminotransferase CTZ18_11000 ENOG4105C0B DNA polymerase III (alpha subunit) CTZ18_11025 ENOG4108JU3 Alkyl hydroperoxide reductase CTZ18_11040 ENOG4108KB2 LysR family Transcriptional regulator CTZ18_11045 ENOG4105D6J arsenicaL-resistance protein CTZ18_11050 ENOG41082YX Transcriptional regulator, arsr family CTZ18_11065 ENOG4105CPN adenine deaminase CTZ18_11075 ENOG4105CBN LysR family transcriptional regulator CTZ18_11085 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CTZ18_11095 ENOG4105E2B Taurine dioxygenase CTZ18_11100 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CTZ18_11105 ENOG4108IY8 ABC, transporter CTZ18_11110 ENOG4106FTQ Taurine ABC transporter, periplasmic CTZ18_11120 ENOG4105C54 Major Facilitator superfamily CTZ18_11145 ENOG4105C4M (Ubiquinol oxidase) subunit I CTZ18_11150 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CTZ18_11160 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CTZ18_11165 ENOG4108K70 Transcriptional regulator CTZ18_11180 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CTZ18_11185 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase CTZ18_11200 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) CTZ18_11205 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CTZ18_11215 ENOG4105DXI Major Facilitator superfamily CTZ18_11235 ENOG41067MG lrgb family CTZ18_11240 ENOG4105VAW lrga family CTZ18_11245 ENOG4105CMU LysR family (Transcriptional regulator CTZ18_11250 ENOG4108SHQ Glutathione S-transferase CTZ18_11255 ENOG4105CYM Glutathione S-transferase CTZ18_11260 ENOG4105CBN LysR family transcriptional regulator CTZ18_11265 ENOG4105CHR reductase CTZ18_11275 ENOG4105D7W serine acetyltransferase CTZ18_11280 ENOG4105ESN nucleotide-binding protein CTZ18_11285 ENOG4105C9B Cysteine desulfurase CTZ18_11295 ENOG4105EXG Transcriptional regulator CTZ18_11305 ENOG4105CT1 (ABC) transporter CTZ18_11310 ENOG4107RP9 extracellular solute-binding protein, family 3 CTZ18_11315 ENOG4105CDA abc transporter atp-binding protein CTZ18_11320 ENOG4108HW4 amino acid AbC transporter CTZ18_11325 ENOG4105EAD ABC transporter CTZ18_11340 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CTZ18_11345 ENOG4105BZU Histidine kinase CTZ18_11355 ENOG4105EW9 transcriptional regulator AsnC family CTZ18_11365 ENOG4105KT5 UmuD protein CTZ18_11385 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CTZ18_11430 ENOG4105HEI LysR family (Transcriptional regulator CTZ18_11450 ENOG4105CEY Amp-dependent synthetase and ligase CTZ18_11455 ENOG4105R8C Transcriptional regulator CTZ18_11460 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_11465 ENOG4107QX3 carboxylase CTZ18_11470 ENOG4105E39 Enoyl-CoA hydratase CTZ18_11485 ENOG4105CC0 LysR family Transcriptional regulator CTZ18_11500 ENOG4105CSU acyl-Coa dehydrogenase CTZ18_11510 ENOG4105EQ0 Major Facilitator superfamily CTZ18_11520 ENOG4107QNJ CoA-transferase subunit B CTZ18_11525 ENOG4107QP7 CoA-transferase subunit A CTZ18_11530 ENOG4107RGD Major Facilitator superfamily CTZ18_11535 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_11540 ENOG4105E39 Enoyl-CoA hydratase CTZ18_11545 ENOG4105CHR reductase CTZ18_11555 ENOG4105CHU acetyl-coa acetyltransferase CTZ18_11565 ENOG4105EQ0 Major Facilitator superfamily CTZ18_11570 ENOG4105EA8 2-Nitropropane dioxygenase CTZ18_11575 ENOG4108UKI Enoyl-CoA hydratase CTZ18_11590 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_11595 ENOG4107RGD Major Facilitator superfamily CTZ18_11600 ENOG4108KAZ Involved in phosphonate degradation (By similarity) CTZ18_11605 ENOG4107STF Involved in phosphonate degradation (By similarity) CTZ18_11615 ENOG4107RCV ABC transporter, permease CTZ18_11620 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CTZ18_11625 ENOG4105C4Y ABC transporter CTZ18_11635 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase CTZ18_11640 ENOG4107HP6 Transcriptional regulator CTZ18_11650 ENOG4105HEI LysR family (Transcriptional regulator CTZ18_11655 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CTZ18_11660 ENOG4105C26 Dehydrogenase CTZ18_11670 ENOG4105ETS cytosine purines uracil thiamine allantoin CTZ18_11680 ENOG4105C26 Dehydrogenase CTZ18_11685 ENOG4108M8W Monooxygenase CTZ18_11690 ENOG4105MXW flavin reductase domain protein, FMN-binding CTZ18_11695 ENOG4108MXF Alpha Beta Hydrolase CTZ18_11715 ENOG4105CPW cytochrome b561 CTZ18_11720 ENOG4107VGR Catalase CTZ18_11760 ENOG4107YAU phenylacetic acid degradation protein CTZ18_11770 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein CTZ18_11775 ENOG4105DZS Phenylacetate-CoA ligase CTZ18_11780 ENOG4105CHU acetyl-coa acetyltransferase CTZ18_11785 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CTZ18_11790 ENOG4108UKI Enoyl-CoA hydratase CTZ18_11795 ENOG4105E39 Enoyl-CoA hydratase CTZ18_11800 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CTZ18_11805 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit CTZ18_11810 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit CTZ18_11815 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit CTZ18_11820 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit CTZ18_11825 ENOG4105DXM phenylacetic acid degradation protein CTZ18_11830 ENOG4105EJQ L-serine dehydratase CTZ18_11835 ENOG4107QTZ amino acid CTZ18_11840 ENOG4105CZJ Aldehyde dehydrogenase CTZ18_11865 ENOG4105MWK D-amino acid dehydrogenase, small subunit CTZ18_11885 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CTZ18_11900 ENOG4108Z4X TRANSCRIPTIONal CTZ18_11915 ENOG4105WPN DNA integration recombination invertion protein CTZ18_11930 ENOG4105DJ2 Major Facilitator Superfamily CTZ18_11935 ENOG4107Y2X deaminase CTZ18_11945 ENOG4105EMY transcriptional regulator CTZ18_11975 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CTZ18_11985 ENOG4105UYK outer membrane protein a CTZ18_12060 ENOG4108HW3 (ABC) transporter CTZ18_12070 ENOG4105MRR Transcriptional regulator (By similarity) CTZ18_12090 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF CTZ18_12095 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CTZ18_12110 ENOG4105E2A Dehydrogenase CTZ18_12120 ENOG4105R8C Transcriptional regulator CTZ18_12145 ENOG4107R4J Chloride channel CTZ18_12150 ENOG4108JIK carboxylase CTZ18_12170 ENOG4105C5A transporter CTZ18_12175 ENOG4108WAV Transcriptional regulator CTZ18_12190 ENOG4105CNA YD repeat protein CTZ18_12230 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) CTZ18_12250 ENOG4105D2S major facilitator superfamily CTZ18_12265 ENOG4105D1S lipid A biosynthesis CTZ18_12270 ENOG4105BZU Histidine kinase CTZ18_12275 ENOG4107AQZ Membrane CTZ18_12295 ENOG4108Z4U Ferredoxin CTZ18_12335 ENOG4105DFG type I secretion outer membrane protein CTZ18_12340 ENOG4108IUZ ABC transporter CTZ18_12345 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA CTZ18_12355 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase CTZ18_12360 ENOG4105C2X Arabinose 5-phosphate isomerase CTZ18_12395 ENOG4107YPT transcriptional regulator CTZ18_12430 ENOG4105II7 pyrroline-5-carboxylate reductase CTZ18_12440 ENOG4105VEQ Cold shock protein CTZ18_12445 ENOG410829K Lysine exporter protein (Lyse ygga) CTZ18_12480 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CTZ18_12535 ENOG4108KB2 LysR family Transcriptional regulator CTZ18_12540 ENOG4105FUY alpha subunit CTZ18_12545 ENOG4108UKV benzoate 1,2-dioxygenase CTZ18_12550 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein CTZ18_12555 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase CTZ18_12560 ENOG4105DKK Benzoate CTZ18_12565 ENOG4105D2S major facilitator superfamily CTZ18_12580 ENOG4105CQ7 ATP-dependent helicase CTZ18_12585 ENOG4105D3R alkyl hydroperoxide reductase CTZ18_12595 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CTZ18_12605 ENOG4108JU3 Alkyl hydroperoxide reductase CTZ18_12615 ENOG4108K3A Glutathione S-transferase CTZ18_12625 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CTZ18_12630 ENOG4108TGY Glutathione S-transferase CTZ18_12640 ENOG4108ZG0 Ompa motb domain protein CTZ18_12645 ENOG4105CD3 dihydroorotase CTZ18_12675 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CTZ18_12690 ENOG4108UKZ OsmC family CTZ18_12700 ENOG4107RYR Transcriptional regulator, Crp Fnr family CTZ18_12705 ENOG4105CPC Aldo Keto reductase CTZ18_12720 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CTZ18_12730 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CTZ18_12740 ENOG4105CFH Aspartokinase CTZ18_12750 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CTZ18_12760 ENOG4105CPW cytochrome b561 CTZ18_12765 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CTZ18_12770 ENOG4105C7N Xanthine uracil vitamin C permease CTZ18_12780 ENOG4105F95 Monooxygenase CTZ18_12950 ENOG4108C33 Resolvase CTZ18_12955 ENOG4105D13 transposase CTZ18_12990 ENOG4105C85 amino acid CTZ18_13010 ENOG4105C26 Dehydrogenase CTZ18_13030 ENOG4105CUB amino acid CTZ18_13040 ENOG4105C85 amino acid CTZ18_13085 ENOG4105CNA YD repeat protein CTZ18_13105 ENOG4105D01 (LipO)protein CTZ18_13110 ENOG4108M3P Membrane CTZ18_13125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CTZ18_13145 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) CTZ18_13165 ENOG4108JQ5 ABC transporter CTZ18_13170 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component CTZ18_13175 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component CTZ18_13185 ENOG4105E9H Lytic Murein transglycosylase CTZ18_13185 ENOG4105E9H Lytic Murein transglycosylase CTZ18_13190 ENOG4107RZZ dna polymerase iii epsilon subunit CTZ18_13200 ENOG4105E09 nadh pyrophosphatase CTZ18_13210 ENOG4105W4M Transport-associated protein CTZ18_13220 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CTZ18_13230 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CTZ18_13235 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CTZ18_13255 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family CTZ18_13260 ENOG4105D0A hydroxylase CTZ18_13265 ENOG4107RAQ aminopeptidase CTZ18_13300 ENOG4105DIJ Phosphoethanolamine transferase CTZ18_13345 ENOG4105DR5 peptidase CTZ18_13670 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CTZ18_13695 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CTZ18_13705 ENOG4105D82 Glutamate dehydrogenase CTZ18_13710 ENOG4108R3D Electron transport complex CTZ18_13715 ENOG4105CSM endonuclease III CTZ18_13740 ENOG4105CJN penicillin-binding protein CTZ18_13745 ENOG4106H78 methyltransferase CTZ18_13760 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CTZ18_13800 ENOG4107RET Isocitrate lyase CTZ18_13810 ENOG4105C37 (CBS) domain CTZ18_13820 ENOG4105D4T Citrate transporter CTZ18_13835 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) CTZ18_13850 ENOG4108MRJ CTZ18_13870 ENOG4105VCQ rubredoxin CTZ18_13875 ENOG4107QZF nitrite reductase NADPH large subunit CTZ18_13885 ENOG4105C5Q Transcriptional regulator CTZ18_13910 ENOG4107U91 Rhomboid family CTZ18_13915 ENOG4105CV6 ABC transporter, permease CTZ18_13920 ENOG4108I0Y (ABC) transporter CTZ18_13925 ENOG4108UJV acyl-CoA thioesterase i CTZ18_13945 ENOG4107RNH Outer membrane receptor FepA CTZ18_13960 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) CTZ18_13965 ENOG4105E6M Sulphatase-modifying factor protein CTZ18_13985 ENOG4105CJ3 phosphate transporter CTZ18_13990 ENOG4105C3R Methionine synthase CTZ18_14005 ENOG4105CSP Major Facilitator Superfamily CTZ18_14015 ENOG4108PZW LysR family Transcriptional regulator CTZ18_14030 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CTZ18_14035 ENOG4105EU0 Major facilitator Superfamily CTZ18_14040 ENOG4108R6W Transcriptional regulator, ARAC family CTZ18_14045 ENOG4105CSV Glutaminase CTZ18_14050 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CTZ18_14055 ENOG4105CSH Transporter CTZ18_14065 ENOG4105C7K acetolactate synthase CTZ18_14080 ENOG4105CHR reductase CTZ18_14085 ENOG4108MXF Alpha Beta Hydrolase CTZ18_14095 ENOG4105DJB Major Facilitator Superfamily CTZ18_14100 ENOG4108DNI pyridine nucleotide-disulfide oxidoreductase CTZ18_14110 ENOG4105CHR reductase CTZ18_14130 ENOG41069M3 Transcriptional regulator CTZ18_14145 ENOG4106YT9 Enoyl-CoA hydratase CTZ18_14155 ENOG4105CND Glycosyl transferase, family 2 CTZ18_14160 ENOG4107BJW polysaccharide deacetylase CTZ18_14170 ENOG4108VWS Yaeq family CTZ18_14180 ENOG4105CKI cobalamin synthesis protein CTZ18_14200 ENOG4105C94 Transporter CTZ18_14205 ENOG4105C94 Transporter CTZ18_14210 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) CTZ18_14235 ENOG4107QK5 Homocysteine s-methyltransferase CTZ18_14240 ENOG4105D5Q Arginine ornithine antiporter CTZ18_14265 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CTZ18_14270 ENOG4105C54 Major Facilitator superfamily CTZ18_14390 ENOG4105DFP Integrase CTZ18_14400 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CTZ18_14405 ENOG4105C0R drug resistance transporter emrb qaca subfamily CTZ18_14410 ENOG4105CW7 secretion protein, HlyD family CTZ18_14415 ENOG4108VUY thioesterase Superfamily protein CTZ18_14420 ENOG4105D52 delta-aminolevulinic acid dehydratase CTZ18_14425 ENOG4105MWK D-amino acid dehydrogenase, small subunit CTZ18_14430 ENOG4105ECP epimerase CTZ18_14450 ENOG4107RH8 nuclease SbcCD subunit D CTZ18_14455 ENOG4105EYH Exonuclease CTZ18_14460 ENOG4105DFA alanine racemase domain protein CTZ18_14465 ENOG4105CZX twitching motility protein CTZ18_14470 ENOG4105CZX twitching motility protein CTZ18_14475 ENOG41090R7 Ferric uptake CTZ18_14505 ENOG4105E7A Glutamine amidotransferase CTZ18_14520 ENOG4107QKV phosphomannomutase CTZ18_14530 ENOG4105C4R Atp-dependent dna helicase CTZ18_14535 ENOG4108ZG0 Ompa motb domain protein CTZ18_14540 ENOG4106HNH Acyl-transferase CTZ18_14555 ENOG4107QMS site-determining protein CTZ18_14580 ENOG4105CNU cell division protein FtsK CTZ18_14585 ENOG4105C3M thioredoxin reductase CTZ18_14590 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) CTZ18_14600 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CTZ18_14645 ENOG4108YXA Membrane CTZ18_14650 ENOG4105EUB pirin domain protein CTZ18_14660 ENOG4105C4K Nad synthetase CTZ18_14675 ENOG4105E3J oxidoreductase CTZ18_14680 ENOG4105C26 Dehydrogenase CTZ18_14685 ENOG4105DVW rieske (2Fe-2S) CTZ18_14695 ENOG4105C94 Transporter CTZ18_14700 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CTZ18_14705 ENOG4105EJC lysr family transcriptional regulator CTZ18_14725 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding CTZ18_14745 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CTZ18_14750 ENOG4105C34 Pseudouridine synthase CTZ18_14755 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane CTZ18_14760 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CTZ18_14775 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) CTZ18_14805 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CTZ18_14835 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CTZ18_14845 ENOG4105DWF phosphomethylpyrimidine kinase CTZ18_14850 ENOG4109066 lysm domain bon superfamily protein CTZ18_14860 ENOG4105CHR reductase CTZ18_14865 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CTZ18_14875 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein CTZ18_14880 ENOG4108BPE -transporting atpase CTZ18_14885 ENOG4107RTD sua5 ycio yrdc ywlc family protein CTZ18_14890 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CTZ18_14895 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CTZ18_14900 ENOG4105FE9 pseudouridine synthase CTZ18_14910 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CTZ18_14915 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CTZ18_14925 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CTZ18_14930 ENOG4108K4C ec 3.1.3.12 CTZ18_14935 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase CTZ18_14940 ENOG4106UW1 Major Facilitator superfamily CTZ18_14960 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CTZ18_14970 ENOG4105HF0 Membrane CTZ18_14985 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY CTZ18_14995 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) CTZ18_15050 ENOG4105D1F ATP-binding protein CTZ18_15060 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CTZ18_15090 ENOG4105K6H D-cysteine desulfhydrase CTZ18_15095 ENOG4105CBX hi0933 family CTZ18_15120 ENOG4105DP0 ferredoxin-NADP reductase CTZ18_15125 ENOG4105DUM transcriptional regulator, lysR family CTZ18_15145 ENOG4105C8S subunit m CTZ18_15150 ENOG4105D65 subunit l CTZ18_15160 ENOG4107UFS subunit j CTZ18_15175 ENOG4108IEH NADH dehydrogenase subunit g CTZ18_15180 ENOG4107QIZ NADH dehydrogenase CTZ18_15185 ENOG4105GKE subunit e CTZ18_15205 ENOG4105BZU Histidine kinase CTZ18_15215 ENOG4105E0F Histidine kinase CTZ18_15220 ENOG4107EXC regulatoR CTZ18_15230 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CTZ18_15240 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CTZ18_15250 ENOG4105EB3 Histidine kinase CTZ18_15320 ENOG4105DZG Dehydrogenase CTZ18_15340 ENOG4105JAB phenazine biosynthesis protein, phzf family CTZ18_15370 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) CTZ18_15375 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CTZ18_15385 ENOG4105ETT transcriptional Regulator, LysR family CTZ18_15405 ENOG4105CH2 amidohydrolase CTZ18_15415 ENOG4106P55 Transcriptional regulator CTZ18_15435 ENOG4106P55 Transcriptional regulator CTZ18_15440 ENOG4107EFR Flavocytochrome c CTZ18_15450 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CTZ18_15455 ENOG4107RGD Major Facilitator superfamily CTZ18_15460 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_15465 ENOG4105ETT transcriptional Regulator, LysR family CTZ18_15500 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CTZ18_15505 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CTZ18_15510 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CTZ18_15525 ENOG4105VR0 copper resistance CTZ18_15530 ENOG4105E3B Multicopper oxidase CTZ18_15540 ENOG4108HCJ Hydrolase CTZ18_15545 ENOG4105DJV ribulose-phosphate 3-epimerase CTZ18_15570 ENOG41072GX Peptidase M22 Glycoprotease CTZ18_15575 ENOG4108Z0R Transferase CTZ18_15620 ENOG4105CRQ synthase (Component I) CTZ18_15630 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CTZ18_15635 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CTZ18_15640 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CTZ18_15710 ENOG4105K56 Transcriptional regulator CTZ18_15715 ENOG4108ZHJ Organic hydroperoxide resistance protein CTZ18_15720 ENOG4107QHF type ii secretion system protein e CTZ18_15740 ENOG4105C2M dna polymerase I CTZ18_15745 ENOG4108VIA integral membrane protein CTZ18_15750 ENOG4105II7 pyrroline-5-carboxylate reductase CTZ18_15755 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CTZ18_15765 ENOG4105C9X ppx gppa phosphatase CTZ18_15775 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CTZ18_15795 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CTZ18_15820 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CTZ18_15835 ENOG4105W39 Membrane CTZ18_15840 ENOG4105CYM Glutathione S-transferase CTZ18_15860 ENOG4105CEY Amp-dependent synthetase and ligase CTZ18_15865 ENOG4105N42 UPF0307 protein CTZ18_15870 ENOG41080Z8 PHOSPHOCARRIER protein CTZ18_15890 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CTZ18_15895 ENOG4105DJ0 Poly(A) Polymerase CTZ18_15900 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein CTZ18_15905 ENOG4105DXN mazG family CTZ18_15915 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CTZ18_15930 ENOG4105C6T cysteine synthase CTZ18_15935 ENOG4105BZU Histidine kinase CTZ18_15940 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase CTZ18_15955 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CTZ18_15960 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CTZ18_15975 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CTZ18_15980 ENOG4105W8H transhydrogenase (subunit alpha CTZ18_15985 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CTZ18_15990 ENOG4106UX7 integral membrane protein CTZ18_16005 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CTZ18_16015 ENOG4107RSM transcriptional regulator CTZ18_16025 ENOG4105CUZ uba thif-type nad fad binding protein CTZ18_16035 ENOG4107QM5 aconitate hydratase CTZ18_16040 ENOG4105F8V Hydrolase, tatD family CTZ18_16055 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CTZ18_16080 ENOG4105BZU Histidine kinase CTZ18_16090 ENOG4108ZP8 Acetolactate synthase small subunit CTZ18_16095 ENOG4105C7K acetolactate synthase CTZ18_16120 ENOG4105DJY efflux transporter, rnd family, mfp subunit CTZ18_16125 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CTZ18_16130 ENOG4105ENJ RND efflux system, outer membrane lipoprotein CTZ18_16135 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CTZ18_16145 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CTZ18_16150 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CTZ18_16160 ENOG4105VW4 glutaredoxin 3 CTZ18_16180 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CTZ18_16185 ENOG4105C2D reductase CTZ18_16195 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CTZ18_16225 ENOG4105C84 Histidine ammonia-lyase CTZ18_16240 ENOG4105CEY Amp-dependent synthetase and ligase CTZ18_16275 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) CTZ18_16295 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) CTZ18_16315 ENOG4105WVQ Fe-S assembly protein IscX CTZ18_16330 ENOG4105CN1 protease CTZ18_16345 ENOG4106HB6 Alpha beta hydrolase CTZ18_16355 ENOG4105C26 Dehydrogenase CTZ18_16360 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CTZ18_16365 ENOG4105C6Z Gluconate CTZ18_16370 ENOG4108UHU Aldolase CTZ18_16375 ENOG4105C01 Dihydroxy-acid dehydratase CTZ18_16380 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CTZ18_16385 ENOG4108DNC Involved in acetate metabolism (By similarity) CTZ18_16390 ENOG4107GFK fumarate CTZ18_16410 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CTZ18_16420 ENOG4108ESX Receptor CTZ18_16430 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CTZ18_16440 ENOG4105DWV Homoserine O-trans-acetylase CTZ18_16540 ENOG4105CIY formyltetrahydrofolate deformylase CTZ18_16550 ENOG4107RGH Aldehyde dehydrogenase CTZ18_16555 ENOG4105KDC 50s ribosomal protein l28 CTZ18_16560 ENOG4105W0E 50S ribosomal protein L33 CTZ18_16565 ENOG4105CKD glutathione-regulated potassium-efflux system protein CTZ18_16585 ENOG4105VFU Rna-binding protein CTZ18_16590 ENOG4105C4R Atp-dependent dna helicase CTZ18_16605 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CTZ18_16615 ENOG4105KVH Transcriptional regulator CTZ18_16625 ENOG41069P5 Protein slyX homolog CTZ18_16630 ENOG4105C5H ABC transporter CTZ18_16635 ENOG4105N14 lysine exporter protein LysE YggA CTZ18_16640 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase CTZ18_16650 ENOG4105CK2 sodium dicarboxylate symporter CTZ18_16715 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CTZ18_16740 ENOG4105DUM transcriptional regulator, lysR family CTZ18_16765 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase CTZ18_16780 ENOG4108W5M transcriptional regulator CTZ18_16795 ENOG4105D29 Helix-turn-helix type 11 domain protein CTZ18_16800 ENOG4107XGZ Hydrolase CTZ18_16805 ENOG4105EI2 Pseudouridine synthase CTZ18_16815 ENOG4105C03 ribonuclease CTZ18_16835 ENOG4105CBN LysR family transcriptional regulator CTZ18_16840 ENOG4105EMU Dehydrogenase CTZ18_16845 ENOG4105CSA Coproporphyrinogen iii oxidase CTZ18_16855 ENOG4107QI1 Mate efflux family protein CTZ18_16865 ENOG4107T8P acyl-Coa dehydrogenase CTZ18_16910 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) CTZ18_16915 ENOG4105C5X domain protein CTZ18_16930 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CTZ18_16940 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase CTZ18_16945 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) CTZ18_16950 ENOG4108JU5 Magnesium and cobalt efflux protein CTZ18_16955 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CTZ18_16960 ENOG4108Z7R Chaperone CsaA CTZ18_16970 ENOG4108VAU general secretion pathway protein G CTZ18_16975 ENOG4105D7Q type ii secretion system CTZ18_16980 ENOG4105C25 Primosomal protein n' CTZ18_16985 ENOG4105CKD glutathione-regulated potassium-efflux system protein CTZ18_16990 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CTZ18_17000 ENOG4105DVC DnaJ domain protein CTZ18_17005 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) CTZ18_17010 ENOG4107QUT magnesium and cobalt transport protein CorA CTZ18_17030 ENOG4107QYX exodeoxyribonuclease v alpha CTZ18_17035 ENOG4107QKA exodeoxyribonuclease V beta CTZ18_17040 ENOG4105DSY exodeoxyribonuclease V, gamma CTZ18_17050 ENOG4105CSR polyphosphate kinase 2 CTZ18_17060 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CTZ18_17075 ENOG41061H0 Monooxygenase CTZ18_17080 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CTZ18_17095 ENOG4105D65 subunit l CTZ18_17100 ENOG4108ZE9 Monovalent cation H antiporter subunit C CTZ18_17105 ENOG4107R4Z monovalent cation h antiporter subunit d CTZ18_17110 ENOG4105SC1 monovalent cation H antiporter subunit E CTZ18_17115 ENOG4105W4C monovalent cation H antiporter subunit F CTZ18_17120 ENOG4105KJM monovalent cation h antiporter subunit g CTZ18_17135 ENOG4105CHV Transcription elongation factor NusA CTZ18_17160 ENOG4107EJC Preprotein translocase subunit SecG CTZ18_17170 ENOG4107QHF type ii secretion system protein e CTZ18_17185 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CTZ18_17195 ENOG4105C2N RNA methyltransferase TrmH family group 3 CTZ18_17210 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CTZ18_17220 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CTZ18_17250 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CTZ18_17255 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CTZ18_17325 ENOG4107ZXU DSBA oxidoreductase CTZ18_17340 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CTZ18_17355 ENOG4105D3Y Na H antiporter CTZ18_17360 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CTZ18_17410 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CTZ18_17415 ENOG4105PM1 preprotein translocase subunit SecE CTZ18_17455 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CTZ18_17460 ENOG4105TV9 FHA Domain-Containing protein CTZ18_17465 ENOG4105GVR general secretion pathway protein D CTZ18_17480 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS CTZ18_17505 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CTZ18_17510 ENOG4108NEV two component transcriptional regulator, LytTR family CTZ18_17515 ENOG4108HRK Histidine kinase CTZ18_17530 ENOG4108UTW Plays a role in the regulation of phosphate uptake CTZ18_17535 ENOG4105DFG type I secretion outer membrane protein CTZ18_17540 ENOG4108RNG Permease of the drug metabolite transporter CTZ18_17565 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CTZ18_17570 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters CTZ18_17575 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) CTZ18_17580 ENOG4105CNI cell division protein FtsW CTZ18_17595 ENOG4105CE1 Ferrous iron transport protein b CTZ18_17605 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CTZ18_17610 ENOG4105T95 Thiol disulfide interChange protein CTZ18_17615 ENOG4105D6E homoserine dehydrogenase CTZ18_17625 ENOG41061WM D-Alanyl-D-Alanine CTZ18_17635 ENOG4107TUY Histidine kinase CTZ18_17640 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CTZ18_17645 ENOG4105CN1 protease CTZ18_17650 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CTZ18_17655 ENOG4108K5H permease YjgP YjgQ family protein CTZ18_17695 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CTZ18_17705 ENOG4105BZU Histidine kinase CTZ18_17720 ENOG4105C0P Mg chelatase subunit ChlI CTZ18_17730 ENOG4108R0M Aminoglycoside CTZ18_17775 ENOG4105CHH sulfate transporter CTZ18_17810 ENOG4105C0P Mg chelatase subunit ChlI CTZ18_17815 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CTZ18_17825 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CTZ18_17835 ENOG4105EPF Outer membrane porin CTZ18_17840 ENOG4105F0N pyrophosphate phospho-hydrolase CTZ18_17855 ENOG4105CEY Amp-dependent synthetase and ligase CTZ18_17860 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CTZ18_17865 ENOG41079KZ Major Facilitator Superfamily CTZ18_17870 ENOG4105EN6 Membrane CTZ18_17880 ENOG4105EE5 Membrane protein terC CTZ18_17885 ENOG4108URH decarboxylase CTZ18_17900 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CTZ18_17915 ENOG4105CCT upf0313 protein CTZ18_17935 ENOG4105CS1 NAD(P)H quinone oxidoreductase CTZ18_17945 ENOG4105C6T cysteine synthase CTZ18_18015 ENOG4105C79 DNA protecting protein DprA CTZ18_18030 ENOG4108IND Tetr family transcriptional regulator CTZ18_18035 ENOG4107RTG Major Facilitator superfamily CTZ18_18045 ENOG4108V06 Glutathione peroxidase CTZ18_18085 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CTZ18_18110 ENOG4105FDK ABC transporter CTZ18_18115 ENOG4105FAV ABC, transporter CTZ18_18125 ENOG4105EZR dyp-type peroxidase family protein CTZ18_18135 ENOG4107R1I NAD-dependent malic enzyme CTZ18_18160 ENOG4105EUB pirin domain protein CTZ18_18180 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CTZ18_18185 ENOG4106MP8 UPF0754 membrane protein CTZ18_18190 ENOG4108VBZ doxx family CTZ18_18195 ENOG4105DQR SNARE associated Golgi CTZ18_18210 ENOG4107QJE Chromosome Partitioning Protein CTZ18_18220 ENOG4107PSF BolA-like protein CTZ18_18240 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CTZ18_18265 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_18290 ENOG4105CSH Transporter CTZ18_18295 ENOG4105E39 Enoyl-CoA hydratase CTZ18_18300 ENOG4105E39 Enoyl-CoA hydratase CTZ18_18305 ENOG4105C1G acyl-Coa dehydrogenase CTZ18_18315 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CTZ18_18320 ENOG4105C26 Dehydrogenase CTZ18_18330 ENOG4105C85 amino acid CTZ18_18335 ENOG4105C85 amino acid CTZ18_18340 ENOG4105M4H endoribonuclease L-psp CTZ18_18355 ENOG4105EW9 transcriptional regulator AsnC family CTZ18_18380 ENOG4105D3G Pseudouridine synthase CTZ18_18395 ENOG4108IG5 Transcriptional regulator CTZ18_18445 ENOG4108I0Z Aconitate hydratase CTZ18_18450 ENOG4105BZN citrate synthase CTZ18_18455 ENOG4105CR4 methylisocitrate lyase CTZ18_18460 ENOG4105DRR Transcriptional regulator, GntR family CTZ18_18470 ENOG4105CGF Aromatic amino acid aminotransferase CTZ18_18475 ENOG4105CXG d-lactate dehydrogenase CTZ18_18485 ENOG41073TP transcriptional regulator CTZ18_18490 ENOG4105DAA L-lactate CTZ18_18495 ENOG4107QKV phosphomannomutase CTZ18_18500 ENOG4105CMR udp-glucose 4-epimerase CTZ18_18510 ENOG4105C6Y Udp-glucose 6-dehydrogenase CTZ18_18515 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CTZ18_18525 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CTZ18_18530 ENOG4107WZ3 Transferase CTZ18_18535 ENOG4105D3Q Sugar transferase CTZ18_18545 ENOG4105C6Y Udp-glucose 6-dehydrogenase CTZ18_18560 ENOG4105K64 Glycosyl transferase, family 2 CTZ18_18565 ENOG4108ZPC Polysaccharide pyruvyl transferase CTZ18_18575 ENOG4107QQG Dehydrogenase CTZ18_18580 ENOG4105DAY polysaccharide export protein CTZ18_18590 ENOG4105D75 Capsular exopolysaccharide family CTZ18_18595 ENOG4108V1T peptidylprolyl cis-trans isomerase CTZ18_18600 ENOG4108V1T peptidylprolyl cis-trans isomerase CTZ18_18605 ENOG4105CJR Integral membrane protein (MviN CTZ18_18610 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase CTZ18_18615 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CTZ18_18625 ENOG4105HSS phospholipase C CTZ18_18655 ENOG41062JF Transcriptional regulator CTZ18_18670 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CTZ18_18675 ENOG4105UBK short-chain dehydrogenase reductase CTZ18_18690 ENOG4107QZM n-acetylglutamate synthase CTZ18_18695 ENOG4105GVF (ABC) transporter CTZ18_18700 ENOG4105GVF (ABC) transporter CTZ18_18705 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CTZ18_18710 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CTZ18_18715 ENOG4108VM9 ABC, transporter CTZ18_18720 ENOG4108R86 Transcriptional regulator CTZ18_18725 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CTZ18_18735 ENOG4105DTN riboflavin biosynthesis protein ribF CTZ18_18740 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CTZ18_18750 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase CTZ18_18790 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) CTZ18_18845 ENOG4105CVE Lytic murein transglycosylase CTZ18_18850 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CTZ18_18855 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CTZ18_18870 ENOG4105DFU Cell wall formation (By similarity) CTZ18_18880 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CTZ18_18885 ENOG4105DU1 integral membrane protein, terc CTZ18_18895 ENOG4106032 Glutathionylspermidine synthase CTZ18_18905 ENOG4107QUY Guanine deaminase CTZ18_18910 ENOG4108UGV hypoxanthine phosphoribosyltransferase CTZ18_18920 ENOG4105T95 Thiol disulfide interChange protein CTZ18_18925 ENOG4105PGM cation diffusion facilitator family transporter CTZ18_18940 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CTZ18_18955 ENOG4105VG0 50S ribosomal protein l34