locus-tag	class	description
AN158_00005	COG0583	DNA-binding transcription factor activity
AN158_00010	COG0183	Belongs to the thiolase family
AN158_00015	COG2031	fatty acid transporter
AN158_00030	COG0583	DNA-binding transcription factor activity
AN158_00045	COG2610	gluconate transmembrane transporter activity
AN158_00050	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_00055	COG2207	Transcriptional regulator
AN158_00065	COG0412	Dienelactone hydrolase
AN158_00070	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_00080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AN158_00095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN158_00095	COG0543	2 iron, 2 sulfur cluster binding
AN158_00100	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AN158_00105	COG4638	Rieske (2fe-2S)
AN158_00115	COG0725	ABC transporter, periplasmic molybdate-binding protein
AN158_00120	COG4149	molybdate abc transporter
AN158_00125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AN158_00130	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_00135	COG1535	isochorismatase
AN158_00135	COG3433	isochorismatase activity
AN158_00195	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN158_00210	COG0753	catalase activity
AN158_00220	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AN158_00245	COG3539	Fimbrial protein
AN158_00260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN158_00265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN158_00270	COG0745	RESPONSE REGULATOR receiver
AN158_00275	COG2205	protein histidine kinase activity
AN158_00285	COG2207	Transcriptional regulator
AN158_00300	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_00305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN158_00310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN158_00315	COG2851	Citrate transporter
AN158_00320	COG1414	Transcriptional regulator
AN158_00330	COG0583	DNA-binding transcription factor activity
AN158_00340	COG0477	Major facilitator Superfamily
AN158_00355	COG2350	Protein conserved in bacteria
AN158_00405	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AN158_00455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AN158_00475	COG1120	ATPase activity
AN158_00490	COG1064	alcohol dehydrogenase
AN158_00495	COG2207	Transcriptional regulator
AN158_00500	COG2084	Dehydrogenase
AN158_00510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN158_00515	COG0583	DNA-binding transcription factor activity
AN158_00525	COG0129	dihydroxy-acid dehydratase activity
AN158_00530	COG1012	belongs to the aldehyde dehydrogenase family
AN158_00545	COG1566	PFAM secretion protein HlyD family protein
AN158_00560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN158_00565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN158_00590	COG0583	DNA-binding transcription factor activity
AN158_00670	COG1473	amidohydrolase
AN158_00680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN158_00680	COG0475	glutathione-regulated potassium exporter activity
AN158_00690	COG0583	DNA-binding transcription factor activity
AN158_00695	COG1335	isochorismatase
AN158_00705	COG1309	transcriptional regulator
AN158_00730	COG0789	Transcriptional regulator
AN158_00760	COG1012	belongs to the aldehyde dehydrogenase family
AN158_00780	COG2186	Transcriptional regulator
AN158_00790	COG0583	DNA-binding transcription factor activity
AN158_00795	COG4948	Mandelate Racemase Muconate Lactonizing
AN158_00800	COG4829	muconolactone delta-isomerase
AN158_00810	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AN158_00815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AN158_00820	COG0183	Belongs to the thiolase family
AN158_00825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN158_00830	COG1012	belongs to the aldehyde dehydrogenase family
AN158_00840	COG3733	amine oxidase
AN158_00850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AN158_00860	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_00870	COG4638	Rieske (2fe-2S)
AN158_00890	COG0154	amidase activity
AN158_00900	COG2814	Major facilitator Superfamily
AN158_00930	COG0583	DNA-binding transcription factor activity
AN158_00935	COG1414	Transcriptional regulator
AN158_00950	COG2391	methyltransferase activity
AN158_00960	COG4993	Dehydrogenase
AN158_00965	COG3659	wide pore channel activity
AN158_00970	COG3420	alginic acid biosynthetic process
AN158_00975	COG0710	3-dehydroquinate dehydratase activity
AN158_00980	COG3485	protocatechuate 3,4-dioxygenase
AN158_00985	COG3485	protocatechuate 3,4-dioxygenase
AN158_00990	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AN158_00995	COG2271	Major facilitator Superfamily
AN158_01000	COG0596	Alpha beta hydrolase
AN158_01005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AN158_01010	COG0183	Belongs to the thiolase family
AN158_01015	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AN158_01020	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AN158_01030	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AN158_01035	COG2323	membrane
AN158_01080	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN158_01080	COG1902	pentaerythritol trinitrate reductase activity
AN158_01095	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN158_01105	COG0542	response to heat
AN158_01110	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AN158_01140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AN158_01145	COG0569	domain protein
AN158_01150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AN158_01165	COG4774	siderophore transport
AN158_01170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AN158_01180	COG1585	Membrane protein implicated in regulation of membrane protease activity
AN158_01195	COG1294	oxidase, subunit
AN158_01200	COG4890	Cyd operon protein YbgT
AN158_01210	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
AN158_01220	COG0552	protein localization to endoplasmic reticulum
AN158_01245	COG0517	IMP dehydrogenase activity
AN158_01245	COG0516	GMP reductase activity
AN158_01250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AN158_01255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AN158_01265	COG0583	DNA-binding transcription factor activity
AN158_01270	COG0024	Methionine aminopeptidase
AN158_01300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN158_01300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AN158_01305	COG1105	Belongs to the carbohydrate kinase PfkB family
AN158_01310	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AN158_01310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN158_01310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AN158_01330	COG3300	MHYT domain
AN158_01330	COG5001	Diguanylate cyclase
AN158_01345	COG2135	peptidase activity
AN158_01350	COG0659	secondary active sulfate transmembrane transporter activity
AN158_01365	COG1113	amino acid transport
AN158_01375	COG1522	sequence-specific DNA binding
AN158_01400	COG1011	Hydrolase
AN158_01405	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AN158_01415	COG2137	regulation of response to DNA damage stimulus
AN158_01425	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN158_01460	COG0575	Belongs to the CDS family
AN158_01465	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AN158_01485	COG3852	Histidine kinase
AN158_01490	COG2204	response regulator
AN158_01545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AN158_01550	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
AN158_01570	COG0697	spore germination
AN158_01575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN158_01585	COG0303	'Molybdopterin
AN158_01590	COG0315	cyclic pyranopterin monophosphate synthase activity
AN158_01590	COG0521	Mo-molybdopterin cofactor biosynthetic process
AN158_01605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AN158_01610	COG0243	molybdopterin cofactor binding
AN158_01620	COG0243	molybdopterin cofactor binding
AN158_01625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN158_01630	COG2146	nitrite reductase [NAD(P)H] activity
AN158_01630	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN158_01640	COG0745	RESPONSE REGULATOR receiver
AN158_01645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN158_01645	COG1116	anion transmembrane transporter activity
AN158_01660	COG0511	ligase activity, forming carbon-carbon bonds
AN158_01675	COG2814	Major facilitator Superfamily
AN158_01695	COG0069	glutamate synthase activity
AN158_01715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AN158_01725	COG1454	alcohol dehydrogenase
AN158_01730	COG0824	Thioesterase
AN158_01740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AN158_01770	COG0183	Belongs to the thiolase family
AN158_01780	COG0583	DNA-binding transcription factor activity
AN158_01795	COG1522	sequence-specific DNA binding
AN158_01800	COG3135	benzoate transporter
AN158_01810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AN158_01830	COG0589	response to stress
AN158_01835	COG0488	(ABC) transporter
AN158_01855	COG4773	Receptor
AN158_01885	COG0668	transmembrane transport
AN158_01910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AN158_01925	COG1605	Chorismate mutase
AN158_01965	COG0308	aminopeptidase N
AN158_01985	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AN158_01995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AN158_02000	COG1454	alcohol dehydrogenase
AN158_02020	COG0531	amino acid
AN158_02025	COG4303	Ethanolamine ammonia lyase large subunit
AN158_02030	COG4302	ethanolamine ammonia-lyase activity
AN158_02035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN158_02035	COG0519	Catalyzes the synthesis of GMP from XMP
AN158_02060	COG0697	spore germination
AN158_02065	COG1923	regulation of RNA biosynthetic process
AN158_02075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AN158_02080	COG0802	atpase or kinase
AN158_02100	COG1187	pseudouridine synthase activity
AN158_02115	COG0583	DNA-binding transcription factor activity
AN158_02130	COG2814	Major facilitator Superfamily
AN158_02135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN158_02160	COG0729	surface antigen
AN158_02180	COG0174	glutamine synthetase
AN158_02185	COG0745	RESPONSE REGULATOR receiver
AN158_02190	COG2205	protein histidine kinase activity
AN158_02200	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AN158_02205	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AN158_02230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AN158_02235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN158_02240	COG1960	acyl-CoA dehydrogenase activity
AN158_02270	COG0583	DNA-binding transcription factor activity
AN158_02285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AN158_02295	COG3658	cytochrome
AN158_02300	COG1215	transferase activity, transferring glycosyl groups
AN158_02305	COG1649	PFAM Uncharacterised BCR, COG1649
AN158_02305	COG0726	polysaccharide deacetylase
AN158_02330	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AN158_02335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AN158_02345	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AN158_02370	COG0305	Participates in initiation and elongation during chromosome replication
AN158_02375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AN158_02385	COG1305	Transglutaminase-like
AN158_02395	COG2308	Evidence 4 Homologs of previously reported genes of
AN158_02425	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AN158_02430	COG0138	bifunctional purine biosynthesis protein purh
AN158_02435	COG0151	Belongs to the GarS family
AN158_02440	COG1464	Belongs to the NlpA lipoprotein family
AN158_02445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AN158_02450	COG2011	ABC-type metal ion transport system permease component
AN158_02455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN158_02465	COG1301	dicarboxylic acid transport
AN158_02495	COG1794	racemase activity, acting on amino acids and derivatives
AN158_02505	COG3008	intermembrane lipid transfer
AN158_02505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AN158_02510	COG2995	paraquat-inducible protein a
AN158_02520	COG2985	domain, Protein
AN158_02555	COG0477	Major facilitator Superfamily
AN158_02605	COG2186	Transcriptional regulator
AN158_02615	COG0786	glutamate:sodium symporter activity
AN158_02620	COG3243	poly(R)-hydroxyalkanoic acid synthase
AN158_02645	COG3111	PFAM Bacterial OB fold (BOF) protein
AN158_02740	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AN158_02745	COG1610	YqeY-like protein
AN158_02750	COG4783	chaperone-mediated protein folding
AN158_02775	COG1286	toxin biosynthetic process
AN158_02805	COG0778	Nitroreductase
AN158_02815	COG0513	Belongs to the DEAD box helicase family
AN158_02835	COG2363	Small membrane protein
AN158_02865	COG1234	tRNA 3'-trailer cleavage
AN158_02870	COG2195	Cleaves the N-terminal amino acid of tripeptides
AN158_02880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AN158_02890	COG2819	hydrolase of the alpha beta superfamily
AN158_02895	COG1960	acyl-CoA dehydrogenase activity
AN158_02900	COG1301	dicarboxylic acid transport
AN158_02910	COG3139	Protein of unknown function (DUF1315)
AN158_02915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AN158_02920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AN158_02930	COG0494	nUDIX hydrolase
AN158_02940	COG0642	Histidine kinase
AN158_02945	COG0745	RESPONSE REGULATOR receiver
AN158_02965	COG1720	tRNA m6t6A37 methyltransferase activity
AN158_02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN158_02990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AN158_03000	COG4598	ABC transporter
AN158_03005	COG4160	amino acid transport
AN158_03010	COG4215	(ABC) transporter
AN158_03025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN158_03035	COG1538	Outer membrane efflux protein
AN158_03065	COG1131	(ABC) transporter
AN158_03070	COG0842	Transport permease protein
AN158_03085	COG0772	Belongs to the SEDS family
AN158_03090	COG2951	lytic endotransglycosylase activity
AN158_03115	COG2207	Transcriptional regulator
AN158_03130	COG0052	Belongs to the universal ribosomal protein uS2 family
AN158_03135	COG0024	Methionine aminopeptidase
AN158_03145	COG2223	nitrite transmembrane transporter activity
AN158_03160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN158_03165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AN158_03170	COG1960	acyl-CoA dehydrogenase activity
AN158_03185	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AN158_03190	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AN158_03195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AN158_03215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN158_03220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AN158_03225	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AN158_03260	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AN158_03275	COG3104	oligopeptide transport
AN158_03285	COG0512	Glutamine amidotransferase of anthranilate synthase
AN158_03290	COG0308	aminopeptidase N
AN158_03310	COG2840	Smr protein MutS2
AN158_03320	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AN158_03350	COG3739	integral membrane protein
AN158_03375	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AN158_03385	COG1132	(ABC) transporter
AN158_03400	COG3433	isochorismatase activity
AN158_03400	COG1535	isochorismatase
AN158_03405	COG1021	2,3-dihydroxybenzoate-AMP ligase
AN158_03410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AN158_03420	COG4774	siderophore transport
AN158_03425	COG4607	ABC-type enterochelin transport system periplasmic component
AN158_03430	COG4604	ABC transporter, ATP-binding protein
AN158_03435	COG4605	iron ion homeostasis
AN158_03440	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AN158_03445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AN158_03460	COG2964	Protein conserved in bacteria
AN158_03470	COG1741	Belongs to the pirin family
AN158_03490	COG2828	Protein conserved in bacteria
AN158_03495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN158_03500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AN158_03505	COG0583	DNA-binding transcription factor activity
AN158_03530	COG3659	wide pore channel activity
AN158_03545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AN158_03555	COG0596	Alpha beta hydrolase
AN158_03570	COG0583	DNA-binding transcription factor activity
AN158_03575	COG1335	isochorismatase
AN158_03615	COG2879	small protein
AN158_03620	COG1966	Carbon starvation protein
AN158_03640	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AN158_03665	COG1067	ATP-dependent peptidase activity
AN158_03670	COG0583	DNA-binding transcription factor activity
AN158_03695	COG1686	Belongs to the peptidase S11 family
AN158_03700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AN158_03735	COG0616	signal peptide processing
AN158_03740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AN158_03750	COG0573	inorganic phosphate transmembrane transporter activity
AN158_03755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AN158_03760	COG1113	amino acid transport
AN158_03765	COG3961	Belongs to the TPP enzyme family
AN158_03770	COG1522	sequence-specific DNA binding
AN158_03780	COG0076	glutamate decarboxylase activity
AN158_03785	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AN158_03795	COG1309	transcriptional regulator
AN158_03810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN158_03845	COG0352	thiamine-phosphate diphosphorylase activity
AN158_03870	COG0612	Peptidase, M16
AN158_03885	COG0583	DNA-binding transcription factor activity
AN158_03890	COG0477	Major facilitator Superfamily
AN158_03910	COG1187	pseudouridine synthase activity
AN158_03925	COG1686	Belongs to the peptidase S11 family
AN158_03930	COG1252	NADH dehydrogenase
AN158_03940	COG0415	Belongs to the DNA photolyase family
AN158_03955	COG1215	transferase activity, transferring glycosyl groups
AN158_03985	COG2070	2-Nitropropane dioxygenase
AN158_04040	COG0556	nucleotide-excision repair
AN158_04085	COG4221	oxidoreductase activity
AN158_04095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AN158_04100	COG1381	Involved in DNA repair and RecF pathway recombination
AN158_04110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AN158_04125	COG0681	Belongs to the peptidase S26 family
AN158_04140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AN158_04160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AN158_04165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AN158_04170	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AN158_04180	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AN158_04185	COG4208	sulfate ABC transporter
AN158_04190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AN158_04195	COG0583	DNA-binding transcription factor activity
AN158_04200	COG4625	pathogenesis
AN158_04215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AN158_04230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AN158_04240	COG1056	cytidyltransferase-related domain
AN158_04240	COG1051	belongs to the nudix hydrolase family
AN158_04245	COG1024	Enoyl-CoA hydratase
AN158_04250	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AN158_04260	COG2814	Major facilitator Superfamily
AN158_04265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AN158_04265	COG0047	phosphoribosylformylglycinamidine synthase activity
AN158_04285	COG1473	amidohydrolase
AN158_04290	COG0824	Thioesterase
AN158_04310	COG0823	Involved in the tonB-independent uptake of proteins
AN158_04330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN158_04365	COG0628	permease
AN158_04375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AN158_04380	COG0596	Alpha beta hydrolase
AN158_04385	COG0616	signal peptide processing
AN158_04385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AN158_04395	COG0658	competence protein
AN158_04395	COG2333	competence protein COMEC
AN158_04400	COG1136	(ABC) transporter
AN158_04405	COG4591	ABC-type transport system involved in lipoprotein release permease component
AN158_04435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN158_04455	COG0463	Glycosyl transferase, family 2
AN158_04485	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AN158_04490	COG1280	lysine exporter protein (LysE YggA)
AN158_04500	COG0019	diaminopimelate decarboxylase activity
AN158_04510	COG1113	amino acid transport
AN158_04525	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AN158_04535	COG3339	Conserved Protein
AN158_04540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AN158_04545	COG0243	molybdopterin cofactor binding
AN158_04550	COG1929	Belongs to the glycerate kinase type-1 family
AN158_04565	COG0778	Nitroreductase
AN158_04585	COG3811	Belongs to the UPF0386 family
AN158_04595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AN158_04610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AN158_04630	COG0741	lytic transglycosylase activity
AN158_04650	COG0584	glycerophosphoryl diester phosphodiesterase
AN158_04655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN158_04680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AN158_04700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AN158_04705	COG0477	Major facilitator Superfamily
AN158_04755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AN158_04760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN158_04785	COG0505	Belongs to the CarA family
AN158_04805	COG0589	response to stress
AN158_04820	COG2843	Capsule synthesis protein
AN158_04840	COG2321	neutral zinc metallopeptidase
AN158_04845	COG2354	Protein conserved in bacteria
AN158_04875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN158_04890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AN158_04895	COG1053	succinate dehydrogenase
AN158_04900	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AN158_04905	COG2009	succinate dehydrogenase
AN158_04940	COG2921	Belongs to the UPF0250 family
AN158_04945	COG0321	lipoyl(octanoyl) transferase activity
AN158_04960	COG0531	amino acid
AN158_04970	COG1733	regulation of RNA biosynthetic process
AN158_04975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AN158_04980	COG1648	precorrin-2 dehydrogenase activity
AN158_04980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AN158_04995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AN158_05025	COG0671	phosphoesterase, PA-phosphatase related
AN158_05030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN158_05040	COG1538	Outer membrane efflux protein
AN158_05045	COG0393	Putative heavy-metal-binding
AN158_05050	COG0393	Putative heavy-metal-binding
AN158_05060	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_05070	COG0525	valine-tRNA ligase activity
AN158_05105	COG0583	DNA-binding transcription factor activity
AN158_05110	COG0004	ammonium transporteR
AN158_05120	COG0642	Histidine kinase
AN158_05125	COG0745	RESPONSE REGULATOR receiver
AN158_05130	COG2194	sulfuric ester hydrolase activity
AN158_05150	COG1752	Esterase of the alpha-beta hydrolase superfamily
AN158_05165	COG2315	Protein conserved in bacteria
AN158_05170	COG0142	geranyltranstransferase activity
AN158_05175	COG2828	Protein conserved in bacteria
AN158_05180	COG1113	amino acid transport
AN158_05200	COG2207	Transcriptional regulator
AN158_05225	COG2249	NAD(P)H dehydrogenase (quinone) activity
AN158_05245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AN158_05255	COG1530	ribonuclease E activity
AN158_05260	COG0424	maF-like protein
AN158_05265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AN158_05270	COG1792	Involved in formation and maintenance of cell shape
AN158_05275	COG1077	Cell shape determining protein MreB Mrl
AN158_05280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN158_05290	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AN158_05315	COG3590	peptidase
AN158_05320	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AN158_05325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AN158_05330	COG1752	Esterase of the alpha-beta hydrolase superfamily
AN158_05335	COG1115	amino acid carrier protein
AN158_05350	COG2814	Major facilitator Superfamily
AN158_05355	COG1289	transmembrane transporter activity
AN158_05405	COG1376	ErfK ybiS ycfS ynhG family protein
AN158_05410	COG2832	Protein of unknown function (DUF454)
AN158_05420	COG5510	response to toxic substance
AN158_05440	COG0840	transmembrane signaling receptor activity
AN158_05480	COG3422	double-strand break repair
AN158_05485	COG2824	Alkylphosphonate utilization operon protein PhnA
AN158_05490	COG3189	MarR family transcriptional regulator
AN158_05500	COG0354	folic acid binding
AN158_05505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN158_05520	COG1902	pentaerythritol trinitrate reductase activity
AN158_05525	COG4772	TonB-dependent receptor
AN158_05530	COG2094	Belongs to the DNA glycosylase MPG family
AN158_05560	COG2233	PERMEase
AN158_05570	COG0833	amino acid
AN158_05575	COG1690	Belongs to the RtcB family
AN158_05585	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AN158_05585	COG2885	chlorophyll binding
AN158_05595	COG0183	Belongs to the thiolase family
AN158_05615	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN158_05635	COG2207	Transcriptional regulator
AN158_05640	COG0183	Belongs to the thiolase family
AN158_05670	COG1272	protein, Hemolysin III
AN158_05675	COG0477	Major facilitator Superfamily
AN158_05690	COG0450	alkyl hydroperoxide reductase
AN158_05710	COG0285	dihydrofolate synthase activity
AN158_05745	COG0133	tryptophan synthase activity
AN158_05760	COG2096	Adenosyltransferase
AN158_05780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AN158_05785	COG0745	RESPONSE REGULATOR receiver
AN158_05790	COG2205	protein histidine kinase activity
AN158_05800	COG1960	acyl-CoA dehydrogenase activity
AN158_05805	COG1960	acyl-CoA dehydrogenase activity
AN158_05810	COG3223	Belongs to the PsiE family
AN158_05880	COG0438	transferase activity, transferring glycosyl groups
AN158_05885	COG0463	Glycosyl transferase, family 2
AN158_05890	COG0726	polysaccharide deacetylase
AN158_05915	COG2205	protein histidine kinase activity
AN158_05950	COG1862	Preprotein translocase
AN158_05960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AN158_05965	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AN158_05975	COG3781	membrane
AN158_05980	COG0613	PHP domain protein
AN158_05990	COG2350	Protein conserved in bacteria
AN158_06020	COG1607	acyl-coa hydrolase
AN158_06035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN158_06035	COG3453	Protein conserved in bacteria
AN158_06080	COG2199	diguanylate cyclase activity
AN158_06090	COG1408	metallophosphoesterase
AN158_06095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AN158_06105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AN158_06125	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AN158_06130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AN158_06145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AN158_06155	COG2969	positive regulation of protein catabolic process
AN158_06175	COG1960	acyl-CoA dehydrogenase activity
AN158_06180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AN158_06195	COG1309	transcriptional regulator
AN158_06200	COG1960	acyl-CoA dehydrogenase activity
AN158_06245	COG1183	phosphatidylcholine synthase activity
AN158_06250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AN158_06280	COG0739	heme binding
AN158_06280	COG1196	nuclear chromosome segregation
AN158_06280	COG0741	lytic transglycosylase activity
AN158_06290	COG1702	phosphate starvation-inducible protein PhoH
AN158_06325	COG1295	ribonuclease BN
AN158_06330	COG0697	spore germination
AN158_06335	COG2169	Transcriptional regulator
AN158_06340	COG0179	Fumarylacetoacetate (FAA) hydrolase
AN158_06385	COG0557	exoribonuclease II activity
AN158_06390	COG0339	signal peptide processing
AN158_06395	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AN158_06425	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AN158_06430	COG1960	acyl-CoA dehydrogenase activity
AN158_06455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AN158_06465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AN158_06585	COG0626	cystathionine gamma-synthase activity
AN158_06590	COG0433	COG0433 Predicted ATPase
AN158_06595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN158_06595	COG1017	nitric oxide dioxygenase activity
AN158_06600	COG1959	2 iron, 2 sulfur cluster binding
AN158_06615	COG1301	dicarboxylic acid transport
AN158_06620	COG1946	Acyl-CoA thioesterase
AN158_06640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AN158_06645	COG1040	competence protein
AN158_06650	COG0494	nUDIX hydrolase
AN158_06660	COG0598	Magnesium transport protein CorA
AN158_06670	COG2854	intermembrane phospholipid transfer
AN158_06680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AN158_06685	COG1127	ABC transporter
AN158_06695	COG0513	Belongs to the DEAD box helicase family
AN158_06715	COG0408	coproporphyrinogen oxidase activity
AN158_06730	COG1960	acyl-CoA dehydrogenase activity
AN158_06740	COG1983	PspC domain protein
AN158_06745	COG0517	IMP dehydrogenase activity
AN158_06795	COG0583	DNA-binding transcription factor activity
AN158_06835	COG1012	belongs to the aldehyde dehydrogenase family
AN158_06845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AN158_06850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN158_06855	COG0833	amino acid
AN158_06885	COG1192	Involved in chromosome partitioning
AN158_06890	COG0628	permease
AN158_06900	COG1289	transmembrane transporter activity
AN158_06915	COG2249	NAD(P)H dehydrogenase (quinone) activity
AN158_06920	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AN158_06930	COG0277	FAD linked oxidase domain protein
AN158_06935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AN158_06960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AN158_06965	COG5380	lipid catabolic process
AN158_06985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AN158_07035	COG0194	GDP metabolic process
AN158_07045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN158_07065	COG3307	-O-antigen
AN158_07085	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AN158_07090	COG1704	LemA family
AN158_07100	COG0493	'glutamate synthase
AN158_07105	COG0067	glutamate synthase
AN158_07105	COG0069	glutamate synthase activity
AN158_07105	COG0070	glutamate synthase
AN158_07155	COG2226	methyltransferase
AN158_07170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AN158_07175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AN158_07220	COG0833	amino acid
AN158_07285	COG0488	(ABC) transporter
AN158_07295	COG4221	oxidoreductase activity
AN158_07300	COG0659	secondary active sulfate transmembrane transporter activity
AN158_07310	COG0745	RESPONSE REGULATOR receiver
AN158_07320	COG0427	acetyl-CoA hydrolase
AN158_07350	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AN158_07370	COG1132	(ABC) transporter
AN158_07385	COG2329	Antibiotic biosynthesis monooxygenase
AN158_07400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AN158_07465	COG2249	NAD(P)H dehydrogenase (quinone) activity
AN158_07470	COG1733	regulation of RNA biosynthetic process
AN158_07500	COG0667	Aldo Keto reductase
AN158_07520	COG0583	DNA-binding transcription factor activity
AN158_07525	COG2814	Major facilitator Superfamily
AN158_07615	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AN158_07635	COG1401	restriction endodeoxyribonuclease activity
AN158_07675	COG1335	isochorismatase
AN158_07685	COG1012	belongs to the aldehyde dehydrogenase family
AN158_07690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AN158_07700	COG1113	amino acid transport
AN158_07710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AN158_07725	COG2814	Major facilitator Superfamily
AN158_07735	COG0352	thiamine-phosphate diphosphorylase activity
AN158_07735	COG0351	phosphomethylpyrimidine kinase
AN158_07735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AN158_07755	COG1309	transcriptional regulator
AN158_07760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AN158_07765	COG3706	GGDEF domain
AN158_07775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN158_07785	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN158_07790	COG3162	membrane
AN158_07795	COG2205	protein histidine kinase activity
AN158_07795	COG0784	Response regulator, receiver
AN158_07795	COG2198	Histidine kinase
AN158_07820	COG1522	sequence-specific DNA binding
AN158_07825	COG1335	isochorismatase
AN158_07830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN158_07840	COG0668	transmembrane transport
AN158_07845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AN158_07850	COG1519	Transferase
AN158_07855	COG1902	pentaerythritol trinitrate reductase activity
AN158_07875	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AN158_07900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AN158_07900	COG0426	domain, Protein
AN158_07905	COG4774	siderophore transport
AN158_07910	COG2119	membrane
AN158_07920	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN158_07930	COG4942	peptidase
AN158_07945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AN158_07955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AN158_07975	COG0189	ligase activity
AN158_07995	COG0708	Exodeoxyribonuclease III
AN158_08000	COG1393	Belongs to the ArsC family
AN158_08015	COG3706	GGDEF domain
AN158_08050	COG2351	hydroxyisourate hydrolase activity
AN158_08055	COG2233	PERMEase
AN158_08065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN158_08075	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AN158_08085	COG3150	esterase
AN158_08100	COG1388	LysM domain
AN158_08110	COG3501	Rhs element vgr protein
AN158_08120	COG2918	glutathione biosynthetic process
AN158_08135	COG2733	membrane
AN158_08140	COG0436	Aminotransferase
AN158_08145	COG0534	Mate efflux family protein
AN158_08230	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AN158_08235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AN158_08245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AN158_08250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AN158_08255	COG0546	phosphoglycolate phosphatase activity
AN158_08265	COG0010	Belongs to the arginase family
AN158_08295	COG2188	Transcriptional regulator
AN158_08305	COG0523	cobalamin synthesis protein
AN158_08315	COG1113	amino acid transport
AN158_08325	COG0625	glutathione transferase activity
AN158_08345	COG1683	Conserved Protein
AN158_08350	COG0534	Mate efflux family protein
AN158_08355	COG0385	Bile acid
AN158_08360	COG1335	isochorismatase
AN158_08365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN158_08385	COG2116	formate transmembrane transporter activity
AN158_08390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AN158_08395	COG2133	pyrroloquinoline quinone binding
AN158_08400	COG2983	Belongs to the UPF0260 family
AN158_08420	COG1194	a g-specific adenine glycosylase
AN158_08435	COG2818	Glycosylase
AN158_08440	COG1064	alcohol dehydrogenase
AN158_08445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN158_08455	COG0583	DNA-binding transcription factor activity
AN158_08460	COG0656	L-ascorbic acid biosynthetic process
AN158_08465	COG2814	Major facilitator Superfamily
AN158_08500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN158_08515	COG2233	PERMEase
AN158_08520	COG0583	DNA-binding transcription factor activity
AN158_08555	COG0733	neurotransmitter:sodium symporter activity
AN158_08600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AN158_08605	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AN158_08610	COG0596	Alpha beta hydrolase
AN158_08635	COG0488	(ABC) transporter
AN158_08640	COG0586	Pfam SNARE associated Golgi protein
AN158_08650	COG0187	DNA topoisomerase II activity
AN158_08660	COG0592	DNA-directed DNA polymerase activity
AN158_08670	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AN158_08685	COG0706	membrane insertase activity
AN158_08700	COG1230	cation diffusion facilitator family transporter
AN158_08705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN158_08725	COG0402	S-adenosylhomocysteine deaminase activity
AN158_08735	COG0754	glutathionylspermidine amidase activity
AN158_08745	COG0861	Integral membrane protein TerC family
AN158_08750	COG0671	phosphoesterase, PA-phosphatase related
AN158_08760	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AN158_08775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AN158_08780	COG2951	lytic endotransglycosylase activity
AN158_08810	COG0583	DNA-binding transcription factor activity
AN158_08835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AN158_08875	COG1047	Peptidyl-prolyl cis-trans
AN158_08885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AN158_08890	COG0196	riboflavin kinase activity
AN158_08900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AN158_08905	COG1309	transcriptional regulator
AN158_08910	COG1116	anion transmembrane transporter activity
AN158_08915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AN158_08920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AN158_08925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN158_08930	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AN158_08950	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_08955	COG0546	phosphoglycolate phosphatase activity
AN158_09010	COG3023	N-Acetylmuramoyl-L-alanine amidase
AN158_09015	COG0728	peptidoglycan biosynthetic process
AN158_09045	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AN158_09095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AN158_09105	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AN158_09120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AN158_09135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AN158_09140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN158_09150	COG2186	Transcriptional regulator
AN158_09160	COG0277	FAD linked oxidase domain protein
AN158_09165	COG1448	Aminotransferase
AN158_09170	COG1802	Transcriptional regulator
AN158_09185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AN158_09220	COG1309	transcriptional regulator
AN158_09235	COG0564	pseudouridine synthase activity
AN158_09260	COG1522	sequence-specific DNA binding
AN158_09275	COG0251	oxidation-reduction process
AN158_09280	COG1113	amino acid transport
AN158_09285	COG1113	amino acid transport
AN158_09305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AN158_09310	COG1960	acyl-CoA dehydrogenase activity
AN158_09315	COG1024	Enoyl-CoA hydratase
AN158_09320	COG1024	Enoyl-CoA hydratase
AN158_09325	COG0477	Major facilitator Superfamily
AN158_09330	COG3916	Acyl-homoserine-lactone synthase
AN158_09340	COG2197	response regulator
AN158_09350	COG1960	acyl-CoA dehydrogenase activity
AN158_09355	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
AN158_09355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AN158_09355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AN158_09355	COG3321	synthase
AN158_09375	COG2267	carboxylic ester hydrolase activity
AN158_09395	COG0271	Belongs to the BolA IbaG family
AN158_09405	COG1192	Involved in chromosome partitioning
AN158_09420	COG0586	Pfam SNARE associated Golgi protein
AN158_09425	COG2259	Doxx family
AN158_09430	COG4399	Belongs to the UPF0754 family
AN158_09435	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AN158_09435	COG0519	Catalyzes the synthesis of GMP from XMP
AN158_09480	COG0281	malic enzyme
AN158_09485	COG2837	iron assimilation
AN158_09490	COG1280	lysine exporter protein (LysE YggA)
AN158_09495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AN158_09500	COG1121	(ABC) transporter
AN158_09565	COG0386	Belongs to the glutathione peroxidase family
AN158_09580	COG1309	transcriptional regulator
AN158_09585	COG0697	spore germination
AN158_09595	COG0758	DNA mediated transformation
AN158_09630	COG1309	transcriptional regulator
AN158_09665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AN158_09675	COG0655	NAD(P)H dehydrogenase (quinone) activity
AN158_09710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AN158_09720	COG0477	Major facilitator Superfamily
AN158_09730	COG1253	flavin adenine dinucleotide binding
AN158_09740	COG2860	membrane
AN158_09745	COG0477	Major facilitator Superfamily
AN158_09755	COG0318	PFAM AMP-dependent synthetase and ligase
AN158_09770	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AN158_09785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN158_09795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN158_09800	COG0606	chelatase, subunit chli
AN158_09810	COG0347	Belongs to the P(II) protein family
AN158_09815	COG0004	ammonium transporteR
AN158_09825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN158_09825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AN158_09865	COG0795	lipopolysaccharide-transporting ATPase activity
AN158_09870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AN158_09875	COG0793	Belongs to the peptidase S41A family
AN158_09890	COG2197	response regulator
AN158_09900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AN158_09910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AN158_09915	COG4974	Belongs to the 'phage' integrase family
AN158_09940	COG0772	Belongs to the SEDS family
AN158_09945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AN158_09950	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AN158_09955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AN158_09980	COG0697	spore germination
AN158_09985	COG1538	Outer membrane efflux protein
AN158_10005	COG3275	phosphorelay sensor kinase activity
AN158_10015	COG0181	hydroxymethylbilane synthase activity
AN158_10060	COG1716	ATPase activity
AN158_10065	COG0546	phosphoglycolate phosphatase activity
AN158_10165	COG2056	Na+-H+ antiporter family
AN158_10180	COG0326	Molecular chaperone. Has ATPase activity
AN158_10195	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AN158_10265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AN158_10270	COG2169	Transcriptional regulator
AN158_10270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN158_10300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AN158_10310	COG0497	DNA recombination
AN158_10325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AN158_10335	COG0237	dephospho-CoA kinase activity
AN158_10385	COG0195	Participates in both transcription termination and antitermination
AN158_10405	COG2212	antiporter activity
AN158_10415	COG0651	ATP synthesis coupled electron transport
AN158_10420	COG1006	Multisubunit Na H antiporter MnhC subunit
AN158_10425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AN158_10425	COG2111	Na H antiporter
AN158_10440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AN158_10445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN158_10460	COG2226	methyltransferase
AN158_10480	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AN158_10485	COG1074	ATP-dependent DNA helicase activity
AN158_10490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AN158_10510	COG0598	Magnesium transport protein CorA
AN158_10515	COG0789	Transcriptional regulator
AN158_10520	COG0484	heat shock protein binding
AN158_10530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AN158_10535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN158_10535	COG0475	glutathione-regulated potassium exporter activity
AN158_10540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AN158_10560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN158_10570	COG4535	Mg2 and Co2 transporter CorC
AN158_10575	COG0425	Belongs to the sulfur carrier protein TusA family
AN158_10585	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AN158_10585	COG0644	oxidoreductase
AN158_10595	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AN158_10610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AN158_10615	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AN158_10650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AN158_10665	COG0534	Mate efflux family protein
AN158_10675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AN158_10680	COG4221	oxidoreductase activity
AN158_10685	COG0583	DNA-binding transcription factor activity
AN158_10705	COG1530	ribonuclease E activity
AN158_10715	COG0546	phosphoglycolate phosphatase activity
AN158_10720	COG2378	regulation of single-species biofilm formation
AN158_10725	COG0625	glutathione transferase activity
AN158_10735	COG0583	DNA-binding transcription factor activity
AN158_10790	COG0473	3-isopropylmalate dehydrogenase activity
AN158_10845	COG1301	dicarboxylic acid transport
AN158_10855	COG1560	Kdo2-lipid A biosynthetic process
AN158_10860	COG1280	lysine exporter protein (LysE YggA)
AN158_10880	COG1733	regulation of RNA biosynthetic process
AN158_10905	COG0210	DNA helicase
AN158_10910	COG0724	RNA recognition motif
AN158_10930	COG4651	solute:proton antiporter activity
AN158_10930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AN158_10935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AN158_10940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AN158_10955	COG0788	formyltetrahydrofolate deformylase activity
AN158_11055	COG2813	Specifically methylates the guanine in position
AN158_11055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN158_11065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN158_11075	COG4774	siderophore transport
AN158_11085	COG0740	serine-type endopeptidase activity
AN158_11105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AN158_11105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AN158_11110	COG0857	belongs to the CobB CobQ family
AN158_11110	COG0280	phosphate acetyltransferase
AN158_11115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AN158_11125	COG0800	Aldolase
AN158_11135	COG3265	gluconokinase activity
AN158_11140	COG1012	belongs to the aldehyde dehydrogenase family
AN158_11150	COG2267	carboxylic ester hydrolase activity
AN158_11165	COG0793	Belongs to the peptidase S41A family
AN158_11200	COG1426	Protein conserved in bacteria
AN158_11240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AN158_11250	COG1162	GTPase activity
AN158_11255	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AN158_11270	COG1538	Outer membrane efflux protein
AN158_11275	COG1136	(ABC) transporter
AN158_11275	COG0577	efflux transmembrane transporter activity
AN158_11280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AN158_11305	COG0028	Belongs to the TPP enzyme family
AN158_11310	COG0440	acetolactate synthase activity
AN158_11340	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AN158_11355	COG0084	hydrolase, TatD family'
AN158_11365	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AN158_11370	COG0583	DNA-binding transcription factor activity
AN158_11380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN158_11385	COG2814	Major facilitator Superfamily
AN158_11395	COG0697	spore germination
AN158_11400	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AN158_11405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AN158_11410	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AN158_11430	COG3622	Belongs to the hyi family
AN158_11435	COG2084	Dehydrogenase
AN158_11440	COG1024	Enoyl-CoA hydratase
AN158_11445	COG0784	Response regulator, receiver
AN158_11445	COG2205	protein histidine kinase activity
AN158_11445	COG5002	protein histidine kinase activity
AN158_11465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AN158_11475	COG3956	TIGRFAM MazG family protein
AN158_11480	COG1555	photosystem II stabilization
AN158_11485	COG0617	tRNA 3'-terminal CCA addition
AN158_11490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AN158_11510	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AN158_11515	COG3028	Belongs to the UPF0307 family
AN158_11520	COG0318	PFAM AMP-dependent synthetase and ligase
AN158_11535	COG0625	glutathione transferase activity
AN158_11540	COG1238	metal cluster binding
AN158_11555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AN158_11580	COG0072	phenylalanine-tRNA ligase activity
AN158_11605	COG0248	Ppx GppA phosphatase
AN158_11615	COG0037	tRNA processing
AN158_11630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN158_11630	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AN158_11655	COG1764	response to oxidative stress
AN158_11660	COG1846	Transcriptional regulator
AN158_11670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN158_11730	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AN158_11735	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AN158_11740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AN158_11750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AN158_11800	COG1214	PFAM Peptidase M22, glycoprotease
AN158_11825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AN158_11830	COG0561	phosphatase activity
AN158_11840	COG2132	Multicopper oxidase
AN158_11860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AN158_11865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AN158_11870	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AN158_11900	COG1063	alcohol dehydrogenase
AN158_11905	COG0583	DNA-binding transcription factor activity
AN158_11910	COG1960	acyl-CoA dehydrogenase activity
AN158_11915	COG2814	Major facilitator Superfamily
AN158_11920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN158_11930	COG1053	succinate dehydrogenase
AN158_11935	COG0583	DNA-binding transcription factor activity
AN158_11950	COG0583	DNA-binding transcription factor activity
AN158_11960	COG0583	DNA-binding transcription factor activity
AN158_11970	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AN158_11975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AN158_12005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AN158_12025	COG0745	RESPONSE REGULATOR receiver
AN158_12030	COG2205	protein histidine kinase activity
AN158_12065	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AN158_12095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AN158_12100	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AN158_12120	COG0583	DNA-binding transcription factor activity
AN158_12140	COG0668	transmembrane transport
AN158_12150	COG2081	HI0933 family
AN158_12155	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AN158_12185	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN158_12185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AN158_12195	COG0489	protein tyrosine kinase activity
AN158_12250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AN158_12260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AN158_12275	COG0730	response to heat
AN158_12285	COG1196	nuclear chromosome segregation
AN158_12305	COG2223	nitrite transmembrane transporter activity
AN158_12310	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AN158_12315	COG1877	trehalose-phosphatase activity
AN158_12320	COG0596	Alpha beta hydrolase
AN158_12320	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AN158_12320	COG2226	methyltransferase
AN158_12335	COG4106	trans-aconitate 2-methyltransferase activity
AN158_12350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AN158_12355	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AN158_12360	COG0009	L-threonylcarbamoyladenylate synthase
AN158_12365	COG3101	peptidyl-lysine hydroxylation
AN158_12370	COG1399	metal-binding, possibly nucleic acid-binding protein
AN158_12395	COG1652	LysM domain
AN158_12400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AN158_12400	COG0352	thiamine-phosphate diphosphorylase activity
AN158_12400	COG0351	phosphomethylpyrimidine kinase
AN158_12410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AN158_12440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AN158_12470	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AN158_12485	COG0358	DNA primase activity
AN158_12495	COG0564	pseudouridine synthase activity
AN158_12520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AN158_12535	COG0583	DNA-binding transcription factor activity
AN158_12540	COG0473	3-isopropylmalate dehydrogenase activity
AN158_12560	COG1012	belongs to the aldehyde dehydrogenase family
AN158_12580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AN158_12580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AN158_12640	COG0456	acetyltransferase
AN158_12650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AN158_12655	COG0492	ferredoxin-NADP+ reductase activity
AN158_12660	COG1674	ftsk spoiiie
AN158_12660	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AN158_12665	COG1280	lysine exporter protein (LysE YggA)
AN158_12685	COG2894	cell division
AN158_12700	COG0204	Acyl-transferase
AN158_12705	COG2885	chlorophyll binding
AN158_12710	COG0210	DNA helicase
AN158_12720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AN158_12735	COG0121	glutamine amidotransferase
AN158_12755	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AN158_12760	COG0735	belongs to the Fur family
AN158_12785	COG0420	3'-5' exonuclease activity
AN158_12805	COG1090	epimerase
AN158_12820	COG2050	protein possibly involved in aromatic compounds catabolism
AN158_12830	COG2814	Major facilitator Superfamily
AN158_12835	COG0405	Gamma-glutamyltransferase
AN158_12885	COG0477	Major facilitator Superfamily
AN158_12890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN158_12915	COG0531	amino acid
AN158_12920	COG2040	homocysteine
AN158_12945	COG1309	transcriptional regulator
AN158_12950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN158_12955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AN158_12965	COG1607	acyl-coa hydrolase
AN158_12975	COG0523	cobalamin synthesis protein
AN158_12985	COG4681	YaeQ
AN158_12995	COG1649	PFAM Uncharacterised BCR, COG1649
AN158_12995	COG0726	polysaccharide deacetylase
AN158_13000	COG1215	transferase activity, transferring glycosyl groups
AN158_13010	COG1024	Enoyl-CoA hydratase
AN158_13025	COG1414	Transcriptional regulator
AN158_13045	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_13060	COG2271	Major facilitator Superfamily
AN158_13070	COG2267	carboxylic ester hydrolase activity
AN158_13075	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_13090	COG0028	Belongs to the TPP enzyme family
AN158_13100	COG0477	Major facilitator Superfamily
AN158_13105	COG0242	peptide deformylase activity
AN158_13110	COG2066	Belongs to the glutaminase family
AN158_13115	COG2207	Transcriptional regulator
AN158_13120	COG2223	nitrite transmembrane transporter activity
AN158_13135	COG0583	DNA-binding transcription factor activity
AN158_13140	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_13145	COG2271	Major facilitator Superfamily
AN158_13150	COG3959	Transketolase, thiamine diphosphate binding domain
AN158_13155	COG3958	Transketolase
AN158_13165	COG0306	phosphate transporter
AN158_13185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AN158_13230	COG4181	ATPase activity
AN158_13235	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AN158_13260	COG0583	DNA-binding transcription factor activity
AN158_13270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AN158_13275	COG1773	rubredoxin
AN158_13320	COG2851	Citrate transporter
AN158_13325	COG1253	flavin adenine dinucleotide binding
AN158_13370	COG0804	urea catabolic process
AN158_13380	COG0830	nickel cation binding
AN158_13395	COG0742	ribosomal rna small subunit methyltransferase
AN158_13400	COG0768	penicillin binding
AN158_13420	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AN158_13425	COG2878	Part of a membrane complex involved in electron transport
AN158_13430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AN158_13440	COG3384	dioxygenase
AN158_13455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AN158_13615	COG5410	chromosome segregation
AN158_13740	COG0739	heme binding
AN158_13830	COG0006	proline dipeptidase activity
AN158_13835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN158_13840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN158_13860	COG1279	arginine transmembrane transporter activity
AN158_13865	COG0583	DNA-binding transcription factor activity
AN158_13905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN158_13910	COG0741	lytic transglycosylase activity
AN158_13910	COG1388	LysM domain
AN158_13910	COG1388	LysM domain
AN158_13910	COG0741	lytic transglycosylase activity
AN158_13915	COG4166	transmembrane transport
AN158_13920	COG4174	ABC transporter (Permease)
AN158_13925	COG4239	(ABC) transporter, permease
AN158_13930	COG4172	Belongs to the ABC transporter superfamily
AN158_13950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AN158_13960	COG5001	Diguanylate cyclase
AN158_13960	COG2203	Gaf domain
AN158_13960	COG3706	GGDEF domain
AN158_13960	COG4251	negative regulation of phosphorylation
AN158_13970	COG1902	pentaerythritol trinitrate reductase activity
AN158_13970	COG0446	pyridine nucleotide-disulphide oxidoreductase
AN158_13985	COG4269	membrane
AN158_14005	COG3501	Rhs element vgr protein
AN158_14010	COG3209	COG3209 Rhs family protein
AN158_14050	COG1113	amino acid transport
AN158_14060	COG0531	amino acid
AN158_14080	COG1012	belongs to the aldehyde dehydrogenase family
AN158_14100	COG1113	amino acid transport
AN158_14115	COG0697	spore germination
AN158_14120	COG2721	sulfolactate sulfo-lyase activity
AN158_14125	COG2271	Major facilitator Superfamily
AN158_14130	COG4948	Mandelate Racemase Muconate Lactonizing
AN158_14140	COG1012	belongs to the aldehyde dehydrogenase family
AN158_14145	COG2186	Transcriptional regulator
AN158_14170	COG1960	acyl-CoA dehydrogenase activity
AN158_14180	COG1012	belongs to the aldehyde dehydrogenase family
AN158_14185	COG1024	Enoyl-CoA hydratase
AN158_14190	COG2814	Major facilitator Superfamily
AN158_14205	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN158_14250	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
AN158_14255	COG2072	flavoprotein involved in K transport
AN158_14260	COG0300	oxidoreductase activity
AN158_14270	COG1309	transcriptional regulator
AN158_14275	COG1741	Belongs to the pirin family
AN158_14290	COG2072	flavoprotein involved in K transport
AN158_14300	COG2252	PERMEase
AN158_14305	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AN158_14310	COG3038	cytochrome b561
AN158_14320	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AN158_14340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AN158_14355	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AN158_14370	COG0667	Aldo Keto reductase
AN158_14380	COG1765	OsmC-like protein
AN158_14430	COG2885	chlorophyll binding
AN158_14440	COG0625	glutathione transferase activity
AN158_14445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AN158_14465	COG3634	alkyl hydroperoxide reductase activity
AN158_14475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AN158_14485	COG0450	alkyl hydroperoxide reductase
AN158_14490	COG1643	Atp-dependent helicase
AN158_14505	COG2814	Major facilitator Superfamily
AN158_14510	COG3135	benzoate transporter
AN158_14515	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_14520	COG0633	Ferredoxin
AN158_14520	COG0543	2 iron, 2 sulfur cluster binding
AN158_14525	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
AN158_14530	COG4638	Rieske (2fe-2S)
AN158_14535	COG0583	DNA-binding transcription factor activity
AN158_14585	COG1570	exodeoxyribonuclease VII activity
AN158_14615	COG1280	lysine exporter protein (LysE YggA)
AN158_14620	COG1278	Cold shock
AN158_14650	COG2814	Major facilitator Superfamily
AN158_14655	COG1733	regulation of RNA biosynthetic process
AN158_14715	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AN158_14725	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AN158_14730	COG1137	ATPase activity
AN158_14735	COG1538	Outer membrane efflux protein
AN158_14775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AN158_14790	COG1522	sequence-specific DNA binding
AN158_14805	COG1560	Kdo2-lipid A biosynthetic process
AN158_14810	COG0598	Magnesium transport protein CorA
AN158_14830	COG2814	Major facilitator Superfamily
AN158_14855	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN158_14875	COG3501	Rhs element vgr protein
AN158_14890	COG3209	COG3209 Rhs family protein
AN158_14920	COG0583	DNA-binding transcription factor activity
AN158_14925	COG1914	H( )-stimulated, divalent metal cation uptake system
AN158_14945	COG4770	biotin carboxylase activity
AN158_14950	COG0038	chloride channel
AN158_14970	COG1063	alcohol dehydrogenase
AN158_14985	COG0439	Biotin carboxylase
AN158_14990	COG2249	NAD(P)H dehydrogenase (quinone) activity
AN158_14995	COG1733	regulation of RNA biosynthetic process
AN158_15010	COG0864	Transcriptional regulator
AN158_15020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN158_15025	COG1116	anion transmembrane transporter activity
AN158_15090	COG2885	chlorophyll binding
AN158_15090	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AN158_15130	COG0583	DNA-binding transcription factor activity
AN158_15140	COG0590	tRNA wobble adenosine to inosine editing
AN158_15145	COG2807	transmembrane transport
AN158_15160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AN158_15170	COG0789	Transcriptional regulator
AN158_15180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AN158_15200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AN158_15225	COG1012	belongs to the aldehyde dehydrogenase family
AN158_15230	COG0531	amino acid
AN158_15235	COG1760	l-serine dehydratase
AN158_15240	COG1012	belongs to the aldehyde dehydrogenase family
AN158_15240	COG2030	dehydratase
AN158_15245	COG3396	Phenylacetate-CoA oxygenase
AN158_15250	COG3460	Phenylacetate-CoA oxygenase
AN158_15255	COG3396	Phenylacetate-CoA oxygenase
AN158_15260	COG2151	metal-sulfur cluster biosynthetic enzyme
AN158_15265	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AN158_15270	COG1024	Enoyl-CoA hydratase
AN158_15275	COG1024	Enoyl-CoA hydratase
AN158_15280	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN158_15285	COG0183	Belongs to the thiolase family
AN158_15290	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AN158_15295	COG3327	negative regulation of DNA-templated transcription, initiation
AN158_15305	COG2050	protein possibly involved in aromatic compounds catabolism
AN158_15330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN158_15335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AN158_15340	COG2271	Major facilitator Superfamily
AN158_15345	COG0753	catalase activity
AN158_15350	COG3038	cytochrome b561
AN158_15355	COG0583	DNA-binding transcription factor activity
AN158_15365	COG1414	Transcriptional regulator
AN158_15370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AN158_15380	COG1840	ABC-type Fe3 transport system, periplasmic component
AN158_15385	COG3842	ATPase activity
AN158_15400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AN158_15405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN158_15410	COG2814	Major facilitator Superfamily
AN158_15415	COG1960	acyl-CoA dehydrogenase activity
AN158_15420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AN158_15430	COG1024	Enoyl-CoA hydratase
AN158_15440	COG2814	Major facilitator Superfamily
AN158_15450	COG0183	Belongs to the thiolase family
AN158_15455	COG1250	3-hydroxyacyl-CoA dehydrogenase
AN158_15460	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_15465	COG1024	Enoyl-CoA hydratase
AN158_15470	COG1960	acyl-CoA dehydrogenase activity
AN158_15475	COG2814	Major facilitator Superfamily
AN158_15480	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AN158_15485	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AN158_15495	COG2814	Major facilitator Superfamily
AN158_15505	COG1960	acyl-CoA dehydrogenase activity
AN158_15520	COG0583	DNA-binding transcription factor activity
AN158_15535	COG1024	Enoyl-CoA hydratase
AN158_15540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AN158_15545	COG1960	acyl-CoA dehydrogenase activity
AN158_15550	COG1309	transcriptional regulator
AN158_15555	COG0318	PFAM AMP-dependent synthetase and ligase
AN158_15575	COG0583	DNA-binding transcription factor activity
AN158_15625	COG1028	Short-chain dehydrogenase reductase Sdr
AN158_15645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AN158_15665	COG2205	protein histidine kinase activity
AN158_15665	COG0784	Response regulator, receiver
AN158_15680	COG0765	amino acid transport
AN158_15685	COG0765	amino acid transport
AN158_15690	COG1126	abc transporter atp-binding protein
AN158_15695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN158_15700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AN158_15710	COG1280	lysine exporter protein (LysE YggA)
AN158_15715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AN158_15720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AN158_15725	COG1045	serine acetyltransferase
AN158_15740	COG0583	DNA-binding transcription factor activity
AN158_15745	COG0625	glutathione transferase activity
AN158_15750	COG0625	glutathione transferase activity
AN158_15755	COG0583	DNA-binding transcription factor activity
AN158_15765	COG1346	cytolysis
AN158_15785	COG2814	Major facilitator Superfamily
AN158_15795	COG0583	DNA-binding transcription factor activity
AN158_15805	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AN158_15810	COG3052	prosthetic group binding
AN158_15830	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AN158_15850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AN158_15860	COG1294	oxidase, subunit
AN158_15865	COG1271	oxidase subunit
AN158_15885	COG0477	Major facilitator Superfamily
AN158_15895	COG4521	taurine ABC transporter
AN158_15900	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AN158_15905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AN158_15910	COG2175	clavaminate synthase activity
AN158_15920	COG1953	Uracil, thiamine, allantoin
AN158_15930	COG0583	DNA-binding transcription factor activity
AN158_15940	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AN158_15955	COG0640	Transcriptional regulator
AN158_15960	COG0798	PFAM Bile acid sodium symporter
AN158_15965	COG0583	DNA-binding transcription factor activity
AN158_15980	COG3634	alkyl hydroperoxide reductase activity
AN158_16020	COG0436	Aminotransferase
AN158_16030	COG0386	Belongs to the glutathione peroxidase family
AN158_16070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AN158_16095	COG0012	GTP binding
AN158_16100	COG2011	ABC-type metal ion transport system permease component
AN158_16105	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AN158_16115	COG1464	Belongs to the NlpA lipoprotein family
AN158_16145	COG0765	amino acid transport
AN158_16150	COG0765	amino acid transport
AN158_16155	COG1126	abc transporter atp-binding protein
AN158_16165	COG1522	sequence-specific DNA binding
AN158_16180	COG1309	transcriptional regulator
AN158_16200	COG0583	DNA-binding transcription factor activity
AN158_16210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AN158_16220	COG0697	spore germination
AN158_16245	COG3121	Chaperone
AN158_16250	COG3539	Fimbrial protein
AN158_16275	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AN158_16275	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AN158_16320	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AN158_16330	COG2353	YceI-like domain
AN158_16340	COG3698	Phosphodiester glycosidase
AN158_16355	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AN158_16360	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AN158_16360	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AN158_16360	COG0506	proline dehydrogenase activity
AN158_16370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AN158_16375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AN158_16395	COG1132	(ABC) transporter
AN158_16400	COG3122	Protein conserved in bacteria
AN158_16405	COG3619	membrane
AN158_16415	COG0640	Transcriptional regulator
AN158_16425	COG2850	peptidyl-arginine hydroxylation
AN158_16430	COG0424	maF-like protein
AN158_16450	COG0191	fructose-bisphosphate aldolase activity
AN158_16455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN158_16470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AN158_16480	COG1192	Involved in chromosome partitioning
AN158_16485	COG1475	DNA binding
AN158_16490	COG0811	peptide transport
AN158_16500	COG1132	(ABC) transporter
AN158_16505	COG1663	tetraacyldisaccharide 4'-kinase activity
AN158_16525	COG0084	hydrolase, TatD family'
AN158_16540	COG2165	general secretion pathway protein
AN158_16570	COG0590	tRNA wobble adenosine to inosine editing
AN158_16590	COG0776	regulation of translation
AN158_16620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AN158_16625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AN158_16665	COG0339	signal peptide processing
AN158_16675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AN158_16710	COG0702	epimerase
AN158_16715	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN158_16735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AN158_16765	COG0316	Belongs to the HesB IscA family
AN158_16770	COG0822	iron-sulfur transferase activity
AN158_16795	COG0776	regulation of translation
AN158_16800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AN158_16805	COG2207	Transcriptional regulator
AN158_16810	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AN158_16815	COG1960	acyl-CoA dehydrogenase activity
AN158_16820	COG1960	acyl-CoA dehydrogenase activity
AN158_16835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AN158_16850	COG2814	Major facilitator Superfamily
AN158_16855	COG4264	IucA IucC family
AN158_16860	COG4264	IucA IucC family
AN158_16870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AN158_16900	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AN158_16915	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AN158_16935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AN158_16940	COG0730	response to heat
AN158_16960	COG4773	Receptor
AN158_16965	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AN158_16980	COG1131	(ABC) transporter
AN158_16985	COG0842	Transport permease protein
AN158_16990	COG0842	Transport permease protein
AN158_17050	COG2226	methyltransferase
AN158_17075	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AN158_17110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AN158_17120	COG0133	tryptophan synthase activity
AN158_17135	COG3706	GGDEF domain
AN158_17150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AN158_17155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AN158_17160	COG0022	dehydrogenase e1 component
AN158_17165	COG0508	dehydrogenase complex catalyzes the overall conversion of
AN158_17170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AN158_17180	COG1063	alcohol dehydrogenase
AN158_17185	COG3781	membrane
AN158_17205	COG0730	response to heat
AN158_17220	COG3708	Transcriptional regulator
AN158_17220	COG2207	Transcriptional regulator
AN158_17225	COG1733	regulation of RNA biosynthetic process
AN158_17230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AN158_17255	COG4521	taurine ABC transporter
AN158_17260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AN158_17280	COG0477	Major facilitator Superfamily
AN158_17290	COG1027	Aspartate ammonia-lyase
AN158_17305	COG0583	DNA-binding transcription factor activity