locus-tag class description E4664_00100 ENOG4105ED4 portal protein E4664_00120 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) E4664_00125 ENOG4105CM2 brancheD-chain amino acid aminotransferase E4664_00140 ENOG4107BJW polysaccharide deacetylase E4664_00150 ENOG4108PQP glycosyl transferase group 1 E4664_00165 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E4664_00190 ENOG4105UGU tonB-dependent Receptor E4664_00210 ENOG4108VY7 phosphate-starvation-inducible protein PsiE E4664_00215 ENOG4105CSU acyl-Coa dehydrogenase E4664_00220 ENOG4105CSU acyl-Coa dehydrogenase E4664_00230 ENOG4105EB3 Histidine kinase E4664_00235 ENOG4105E3W Two component transcriptional regulator (Winged helix family E4664_00240 ENOG4105CNG UPF0061 protein E4664_00260 ENOG4108WBT adenosyltransferase E4664_00265 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) E4664_00275 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) E4664_00310 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase E4664_00330 ENOG4105D3R alkyl hydroperoxide reductase E4664_00345 ENOG4105CSH Transporter E4664_00350 ENOG4108UT2 hemolysin iii E4664_00380 ENOG4105CHU acetyl-coa acetyltransferase E4664_00385 ENOG4108R6W Transcriptional regulator, ARAC family E4664_00395 ENOG4105TW1 Carbohydrate-selective porin OprB E4664_00400 ENOG4105DZG Dehydrogenase E4664_00405 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) E4664_00425 ENOG4105CHU acetyl-coa acetyltransferase E4664_00435 ENOG4108WHA ompa motb domain protein E4664_00440 ENOG4105E0Y RtcB Protein E4664_00445 ENOG4108IQI permease E4664_00455 ENOG4105C2W permease E4664_00475 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) E4664_00485 ENOG4108VX5 3-methyladenine DNA glycosylase E4664_00490 ENOG4105CHB tonB-dependent Receptor E4664_00495 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4664_00500 ENOG4108N2Y auxin Efflux E4664_00510 ENOG4105T95 Thiol disulfide interChange protein E4664_00515 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) E4664_00530 ENOG4105K78 MarR family Transcriptional regulator E4664_00535 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA E4664_00540 ENOG4105KWI UPF0339 protein E4664_00565 ENOG4108UNF response regulator E4664_00570 ENOG4105M3Z response regulator E4664_00575 ENOG4108ZGA chew protein E4664_00580 ENOG4105C8Q Methyl-accepting chemotaxis E4664_00585 ENOG4105CBS Chea signal transduction histidine kinase E4664_00600 ENOG4106HKS Entericidin EcnA/B family E4664_00610 ENOG4105WD1 Membrane E4664_00615 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein E4664_00655 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) E4664_00665 ENOG4105EM2 membrane E4664_00670 ENOG4105C2C drug resistance transporter, Bcr CflA E4664_00690 ENOG4105BZG amino acid carrier protein E4664_00695 ENOG4105D78 K07001 NTE family protein E4664_00700 ENOG4105C7B Threonine dehydratase E4664_00710 ENOG4105C9K Endothelin-converting enzyme 1 E4664_00735 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E4664_00745 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) E4664_00750 ENOG4105DFF Rod shape-determining protein mreb E4664_00755 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) E4664_00760 ENOG4105VQ7 Rod shape-determining protein MreD E4664_00765 ENOG4108Z03 MAF-like protein E4664_00770 ENOG4105C03 ribonuclease E4664_00780 ENOG4105D8T Acyltransferase E4664_00790 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein E4664_00800 ENOG4108X0B nad(p)h dehydrogenase (quinone) E4664_00825 ENOG4105CF7 AraC family transcriptional regulator E4664_00885 ENOG4105C85 amino acid E4664_00890 ENOG4105C7F AcnD-accessory protein PrpF E4664_00895 ENOG4105CTB Polyprenyl synthetase E4664_00900 ENOG4105MSB protein, conserved in bacteria E4664_00915 ENOG4105D78 K07001 NTE family protein E4664_00940 ENOG4105DIJ Phosphoethanolamine transferase E4664_00945 ENOG4105XJC Two component transcriptional regulator (Winged helix family E4664_00950 ENOG4105DHQ Histidine kinase E4664_00970 ENOG4108M0I Transcriptional regulator E4664_00985 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) E4664_00990 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) E4664_01010 ENOG4105K8R UPF0145 protein E4664_01015 ENOG4105K8R UPF0145 protein E4664_01020 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E4664_01025 ENOG4105BZS acriflavin resistance protein E4664_01030 ENOG4105C1P efflux transporter, rnd family, mfp subunit E4664_01035 ENOG410841Q phosphoesterase PA-phosphatase related protein E4664_01065 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) E4664_01080 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) E4664_01085 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) E4664_01100 ENOG4105CUB amino acid E4664_01115 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) E4664_01120 ENOG41084BA UPF0250 protein E4664_01125 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E4664_01155 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit E4664_01160 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein E4664_01170 ENOG4105E33 succinate dehydrogenase E4664_01185 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 E4664_01190 ENOG4105C7S Dehydrogenase E4664_01195 ENOG4107QN2 dihydrolipoyl dehydrogenase E4664_01205 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha E4664_01215 ENOG4105CKW Inner membrane protein yedI E4664_01220 ENOG4105CGZ zinc metallopeptidase E4664_01225 ENOG4105EEQ Na H antiporter E4664_01240 ENOG4105PNM synthesis protein E4664_01255 ENOG41080TK Universal stress protein E4664_01265 ENOG4108UQ8 endoribonuclease L-psp E4664_01270 ENOG4108IG5 Transcriptional regulator E4664_01280 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain E4664_01285 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain E4664_01300 ENOG4105HBR Rna-binding protein E4664_01310 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) E4664_01315 ENOG4105EEI dihydropteroate synthase E4664_01365 ENOG4105CSH Transporter E4664_01370 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) E4664_01375 ENOG4105C6V Glycerol-3-phosphate dehydrogenase E4664_01390 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E4664_01405 ENOG41080IJ Diacylglycerol kinase E4664_01415 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase E4664_01420 ENOG4105BZS acriflavin resistance protein E4664_01435 ENOG4105E4C Lytic transglycosylase catalytic E4664_01460 ENOG4108RRZ Transcription elongation factor GreB E4664_01470 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) E4664_01495 ENOG4105C59 p-type ATPase E4664_01500 ENOG4105GR3 Histidine kinase E4664_01515 ENOG4105E3B Multicopper oxidase E4664_01545 ENOG4105CEY Amp-dependent synthetase and ligase E4664_01580 ENOG4105BZW Glycerate kinase E4664_01585 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit E4664_01590 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) E4664_01605 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) E4664_01615 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) E4664_01620 ENOG4105BZG amino acid carrier protein E4664_01625 ENOG4105C85 amino acid E4664_01635 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) E4664_01645 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) E4664_01650 ENOG4105N14 lysine exporter protein LysE YggA E4664_01655 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E4664_01660 ENOG4105BZJ Electron transfer flavoprotein E4664_01665 ENOG4105C10 Electron transfer flavoprotein E4664_01670 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4664_01705 ENOG4107KET secretion protein, HlyD family E4664_01735 ENOG4105D60 lipoprotein releasing system transmembrane protein E4664_01740 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) E4664_01745 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 E4664_01755 ENOG4108E8C ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) E4664_01760 ENOG4107R6F Alpha Beta Hydrolase Fold protein E4664_01765 ENOG4108V3E phosphoribosylglycinamide formyltransferase E4664_01775 ENOG4105C02 permease E4664_01825 ENOG4105KCK Peptidoglycan-associated lipoprotein E4664_01830 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) E4664_01840 ENOG4105M8F Biopolymer transport protein exbD tolR E4664_01845 ENOG4105E02 MotA TolQ exbB proton channel E4664_01850 ENOG4107YD3 Thioesterase E4664_01855 ENOG4105CH2 amidohydrolase E4664_01875 ENOG4108ETH Formylglycinamide ribotide synthetase E4664_01880 ENOG4105C2C drug resistance transporter, Bcr CflA E4664_01885 ENOG4105EGD dinuclear metal center protein, YbgI family E4664_01890 ENOG4108UKI Enoyl-CoA hydratase E4664_01905 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen E4664_01920 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) E4664_01925 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) E4664_01940 ENOG4107R11 Transcriptional regulator E4664_01945 ENOG4108IJ6 ABC transporter E4664_01955 ENOG4108I5D sulfate abc transporter E4664_01970 ENOG4105YAZ 4-amino-4-deoxychorismate lyase E4664_01975 ENOG4105HHA aminodeoxychorismate lyase E4664_01990 ENOG4108IYU L-aspartate oxidase E4664_01995 ENOG4105C0H protease E4664_02010 ENOG4105C3F Signal peptidase i E4664_02025 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) E4664_02035 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) E4664_02040 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) E4664_02045 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase E4664_02050 ENOG4105EMU Dehydrogenase E4664_02080 ENOG4105F7F Chaperone E4664_02100 ENOG4105BZU Histidine kinase E4664_02110 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) E4664_02120 ENOG4105DTR rard protein E4664_02160 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E4664_02165 ENOG4105EA8 2-Nitropropane dioxygenase E4664_02195 ENOG4107R8N Glycosyl transferase, family 2 E4664_02210 ENOG4105CVP deoxyribo-dipyrimidine photolyase E4664_02215 ENOG4108YZY peptidylprolyl cis-trans isomerase E4664_02220 ENOG4105CEP NADH dehydrogenase E4664_02225 ENOG4105DZ1 carboxypeptidase E4664_02235 ENOG4105E9K Isocitrate dehydrogenase E4664_02240 ENOG4108R99 pseudouridine synthase E4664_02265 ENOG4105CBP Major Facilitator E4664_02270 ENOG4105EGI Transcriptional regulator E4664_02275 ENOG4108ETY sodium dicarboxylate symporter E4664_02280 ENOG4105JAB phenazine biosynthesis protein, phzf family E4664_02310 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) E4664_02325 ENOG4105D3G Pseudouridine synthase E4664_02330 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) E4664_02345 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E4664_02370 ENOG4108JPW Aminotransferase E4664_02375 ENOG4105DY8 decarboxylase E4664_02385 ENOG4105F7P transcriptional regulator AsnC family E4664_02390 ENOG4107RA9 decarboxylase E4664_02395 ENOG4105C85 amino acid E4664_02400 ENOG4105CVA phosphate E4664_02405 ENOG4105C8U phosphate abc transporter E4664_02415 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) E4664_02420 ENOG4105ERU peptidase E4664_02435 ENOG4107QTF adenylosuccinate lyase E4664_02455 ENOG4108Z0R Transferase E4664_02460 ENOG4105DZ1 carboxypeptidase E4664_02480 ENOG4108K5P (LipO)protein E4664_02485 ENOG4105EJC lysr family transcriptional regulator E4664_02490 ENOG4105DAN ATP-dependent protease E4664_02505 ENOG4105DHU Bile acid E4664_02515 ENOG41066DG (EAL) domain protein E4664_02525 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein E4664_02535 ENOG4105D22 carbon starvation protein E4664_02540 ENOG4105VCD cytoplasmic protein E4664_02580 ENOG4105C2I pirin domain protein E4664_02590 ENOG4105WWK YheO domain protein E4664_02605 ENOG4105CEY Amp-dependent synthetase and ligase E4664_02620 ENOG4108IPW abc transporter atp-binding protein E4664_02640 ENOG4105C0W non-ribosomal peptide synthetase E4664_02645 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase E4664_02650 ENOG4105WQI isochorismatase E4664_02665 ENOG4105BZ1 (ABC) transporter E4664_02670 ENOG4108JJ7 ABC transporter E4664_02685 ENOG4105E4F Isochorismate synthase E4664_02700 ENOG4105NX3 Membrane E4664_02720 ENOG4105EUJ GTP cyclohydrolase i E4664_02730 ENOG4105C7W Xanthine dehydrogenase E4664_02765 ENOG4105DDQ anthranilate synthase E4664_02775 ENOG4105DUX Transporter E4664_02780 ENOG4105C5F glutamine synthetase E4664_02790 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) E4664_02825 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E4664_02830 ENOG4107QNR UPF0135 protein E4664_02835 ENOG4105C0H protease E4664_02845 ENOG4105C6K Malic enzyme E4664_02850 ENOG4105BZU Histidine kinase E4664_02855 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) E4664_02860 ENOG4105SYT Methylenetetrahydrofolate reductase E4664_02865 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) E4664_02880 ENOG4107QPN acyl-Coa dehydrogenase E4664_02885 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E4664_02890 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) E4664_02900 ENOG4107RNU major facilitator superfamily MFS_1 E4664_02910 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E4664_02915 ENOG4105CE9 30S ribosomal protein S2 E4664_02955 ENOG4105CVE Lytic murein transglycosylase E4664_02975 ENOG4105E3A (ABC) transporter E4664_02980 ENOG4105DA5 (ABC) transporter E4664_03030 ENOG4105RDA repressor E4664_03555 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E4664_03565 ENOG4105ENT Efflux transporter rnd family, mfp subunit E4664_03575 ENOG4105E89 ABC transporter E4664_03580 ENOG4105DSP amino acid AbC transporter E4664_03585 ENOG4106YG3 ABC transporter E4664_03590 ENOG4108JEH abc transporter atp-binding protein E4664_03600 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E4664_03605 ENOG4105CFP Peptidase U32 E4664_03610 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4664_03615 ENOG4105JAB phenazine biosynthesis protein, phzf family E4664_03620 ENOG4105DP0 ferredoxin-NADP reductase E4664_03625 ENOG4108R96 Methyltransferase, YaeB family E4664_03635 ENOG4107QHF type ii secretion system protein e E4664_03645 ENOG4105XJC Two component transcriptional regulator (Winged helix family E4664_03650 ENOG4105DHQ Histidine kinase E4664_03660 ENOG4105M6F mutator MutT protein E4664_03670 ENOG4105BZ4 penicillin-binding protein E4664_03675 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) E4664_03680 ENOG4105VUT cytoplasmic protein E4664_03695 ENOG4105CK2 sodium dicarboxylate symporter E4664_03700 ENOG4105C1G acyl-Coa dehydrogenase E4664_03710 ENOG4105CQC Prephenate dehydratase E4664_03715 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase E4664_03725 ENOG4105CIN aminoacyl-histidine dipeptidase E4664_03745 ENOG4105E0Y RtcB Protein E4664_03750 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) E4664_03755 ENOG4105CYB regulatoR E4664_03785 ENOG4105M08 Membrane E4664_03790 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) E4664_03800 ENOG4105VEQ Cold shock protein E4664_03805 ENOG4105C1J atp-dependent rna helicase E4664_03815 ENOG41069NU Nitroreductase E4664_03970 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase E4664_03985 ENOG4105C5I Dehydrogenase E4664_03990 ENOG4105ERG peptidase m48, ste24p E4664_03995 ENOG4105KTH gatB Yqey E4664_04000 ENOG4105VCC 30S ribosomal protein S21 E4664_04025 ENOG4105D9P serine threonine protein kinase E4664_04050 ENOG4105EVZ LysR family transcriptional regulator E4664_04055 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) E4664_04060 ENOG4105C26 Dehydrogenase E4664_04095 ENOG4105H4F exported protein E4664_04125 ENOG4105D6U Sodium Glutamate Symporter E4664_04135 ENOG4105JXH GntR family transcriptional regulator E4664_04175 ENOG4105F1S paraquat-inducible protein a E4664_04180 ENOG4105DY2 Paraquat-inducible protein b E4664_04190 ENOG4105VT2 5-hydroxyisourate hydrolase E4664_04230 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E4664_04240 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase E4664_04245 ENOG4105DHQ Histidine kinase E4664_04250 ENOG4105ETX regulatoR E4664_04300 ENOG4105CK2 sodium dicarboxylate symporter E4664_04310 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) E4664_04315 ENOG4108UMI ABC transporter, permease E4664_04320 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E4664_04330 ENOG4105C12 Phosphoribosylglycinamide synthetase E4664_04335 ENOG4105DC1 bifunctional purine biosynthesis protein purh E4664_04340 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) E4664_04390 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) E4664_04395 ENOG4105CDU Replicative dna helicase E4664_04420 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) E4664_04425 ENOG4105CCU oxidase (Subunit III) E4664_04430 ENOG4105BZ9 Cytochrome C oxidase, subunit I E4664_04435 ENOG4105E2S oxidase) subunit II E4664_04460 ENOG4107BJW polysaccharide deacetylase E4664_04465 ENOG4105CND Glycosyl transferase, family 2 E4664_04470 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD E4664_04480 ENOG4105DEN Luciferase family E4664_04500 ENOG4105CC0 LysR family Transcriptional regulator E4664_04515 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) E4664_04530 ENOG4105C1G acyl-Coa dehydrogenase E4664_04540 ENOG4108MEJ flavin reductase domain protein E4664_04545 ENOG4105D06 uba thif-type nad fad binding protein E4664_04565 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E4664_04570 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) E4664_04575 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) E4664_04580 ENOG4105C08 Histidine kinase E4664_04585 ENOG4105EEX Two component transcriptional regulator (Winged helix family E4664_04590 ENOG4105CFQ glutamine synthetase E4664_04605 ENOG4107S74 Lysophospholipid transporter LplT E4664_04610 ENOG4105CFU surface antigen E4664_04650 ENOG41083X2 DNA polymerase III, epsilon subunit E4664_04940 ENOG4105K4U addiction module toxin, RelE StbE family E4664_04980 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E4664_05065 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E4664_05085 ENOG4107QIJ Aconitate hydratase 2 E4664_05095 ENOG4105EYW Ion transport protein E4664_05100 ENOG4105F27 Major Facilitator E4664_05115 ENOG4105DZ2 Transcriptional regulator E4664_05150 ENOG4105K8N protein family UPF0079, ATPase E4664_05155 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) E4664_05165 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) E4664_05170 ENOG4108TZV Membrane E4664_05175 ENOG4108RCM Nitroreductase E4664_05185 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) E4664_05200 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E4664_05205 ENOG4107FQ9 ethanolamine ammonia-lyase E4664_05210 ENOG4105CPD ethanolamine ammonia-lyase E4664_05215 ENOG4107R55 ethanolamine transporter E4664_05225 ENOG4107RR1 TRANSCRIPTIONal E4664_05235 ENOG4105C0A alcohol dehydrogenase E4664_05240 ENOG4107QUV Domain protein E4664_05265 ENOG4105CD8 aminopeptidase N E4664_05280 ENOG4108D1K outer membrane usher protein E4664_05305 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) E4664_05310 ENOG4105EW9 transcriptional regulator AsnC family E4664_05325 ENOG4105R8C Transcriptional regulator E4664_05335 ENOG4105CUY Mechanosensitive ion channel E4664_05365 ENOG4105D5G Transposase E4664_05375 ENOG4105CNM Receptor E4664_05395 ENOG4105C5H ABC transporter E4664_05400 ENOG41081QV Universal stress protein E4664_05415 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic E4664_05425 ENOG4105DKK Benzoate E4664_05430 ENOG4105EW9 transcriptional regulator AsnC family E4664_05435 ENOG4108NIW Leucine export protein LeuE E4664_05440 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) E4664_05445 ENOG4105CC0 LysR family Transcriptional regulator E4664_05455 ENOG4105CHU acetyl-coa acetyltransferase E4664_05460 ENOG4105CHR reductase E4664_05495 ENOG4107QMP dna polymerase iii subunits gamma and tau E4664_05500 ENOG4105HSS phospholipase C E4664_05510 ENOG4105C0A alcohol dehydrogenase E4664_05550 ENOG4105CBC glutamate synthase E4664_05695 ENOG4105D8G Major Facilitator superfamily E4664_05705 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase E4664_05710 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein E4664_05735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E4664_05745 ENOG4107QZF nitrite reductase NADPH large subunit E4664_05750 ENOG4108IFG nitrite reductase, (NAD(P)H) E4664_05785 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) E4664_05790 ENOG4105CVM Molybdenum cofactor synthesis domain protein E4664_05800 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4664_05805 ENOG4105T38 integral membrane protein E4664_05825 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) E4664_05830 ENOG4105CMR udp-glucose 4-epimerase E4664_05890 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E4664_05895 ENOG4105CUX Signal transduction histidine kinase E4664_05920 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) E4664_05925 ENOG4105KNE Phosphatidate cytidylyltransferase E4664_05940 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E4664_05960 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E4664_05975 ENOG4105Y3E Modulates RecA activity (By similarity) E4664_05985 ENOG4105VEJ Heat shock protein E4664_05990 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 E4664_06015 ENOG4105F7P transcriptional regulator AsnC family E4664_06025 ENOG4105C85 amino acid E4664_06040 ENOG4105CHH sulfate transporter E4664_06045 ENOG4108RAV Conserved protein E4664_06060 ENOG4105BZU Histidine kinase E4664_06075 ENOG4105DM4 PTS System E4664_06080 ENOG4105DE4 1-phosphofructokinase E4664_06085 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) E4664_06110 ENOG4105CWM branched-chain amino acid transport system II carrier protein E4664_06115 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) E4664_06120 ENOG4105CC0 LysR family Transcriptional regulator E4664_06130 ENOG4105M2J Glutaredoxin E4664_06135 ENOG4105C8Y Acetylornithine aminotransferase E4664_06140 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E4664_06165 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) E4664_06175 ENOG41068P6 UPF0319 protein E4664_06195 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E4664_06200 ENOG4105C4M (Ubiquinol oxidase) subunit I E4664_06210 ENOG4105PV3 Inner membrane protein yqiJ E4664_06225 ENOG4105E0K tonB-dependent siderophore receptor E4664_06235 ENOG4105HDD phospholipase E4664_06240 ENOG4105CZN Potassium uptake protein E4664_06250 ENOG4105C7B Threonine dehydratase E4664_06280 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) E4664_06285 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E4664_06295 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E4664_06310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4664_06355 ENOG4107VMU Membrane E4664_06365 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) E4664_06375 ENOG4107QP7 CoA-transferase subunit A E4664_06380 ENOG4107QNJ CoA-transferase subunit B E4664_06385 ENOG4105CHU acetyl-coa acetyltransferase E4664_06390 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase E4664_06395 ENOG4105F2Z 3-oxoadipate enol-lactonase E4664_06400 ENOG4105D2S major facilitator superfamily E4664_06405 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase E4664_06410 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta E4664_06415 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha E4664_06420 ENOG4105FF2 Type I DHQase E4664_06425 ENOG4106JPM 3-dehydroshikimate dehydratase E4664_06430 ENOG4105TW1 Carbohydrate-selective porin OprB E4664_06435 ENOG4105DZG Dehydrogenase E4664_06445 ENOG4105MD1 YeeE YedE family protein E4664_06460 ENOG4107HP6 Transcriptional regulator E4664_06465 ENOG4108PTX LysR family Transcriptional regulator E4664_06470 ENOG4105C1G acyl-Coa dehydrogenase E4664_06500 ENOG4105DNH Major Facilitator E4664_06510 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) E4664_06530 ENOG4105FUY alpha subunit E4664_06540 ENOG4105CHR reductase E4664_06560 ENOG4105F11 amine oxidase E4664_06570 ENOG4105C26 Dehydrogenase E4664_06580 ENOG4105F2Z 3-oxoadipate enol-lactonase E4664_06585 ENOG4105CHU acetyl-coa acetyltransferase E4664_06590 ENOG4107QNJ CoA-transferase subunit B E4664_06605 ENOG4105NN7 muconolactone delta-isomerase E4664_06610 ENOG4105DTQ mandelate racemase muconate lactonizing E4664_06615 ENOG4108KB2 LysR family Transcriptional regulator E4664_06625 ENOG4107EJG GntR family transcriptional regulator E4664_06645 ENOG4105CZJ Aldehyde dehydrogenase E4664_06660 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4664_06700 ENOG4107Z3H Transcriptional regulator, TetR family E4664_06705 ENOG4108PTX LysR family Transcriptional regulator E4664_06710 ENOG41061TZ Short-chain dehydrogenase reductase Sdr E4664_06715 ENOG41061TZ Short-chain dehydrogenase reductase Sdr E4664_06720 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr E4664_06730 ENOG4105CSU acyl-Coa dehydrogenase E4664_06740 ENOG4105CEY Amp-dependent synthetase and ligase E4664_06790 ENOG4105FDP GntR family transcriptional regulator E4664_06805 ENOG4106KR7 LysR family Transcriptional regulator E4664_06825 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein E4664_06830 ENOG4105CW7 secretion protein, HlyD family E4664_06845 ENOG4105CZJ Aldehyde dehydrogenase E4664_06850 ENOG4105C01 Dihydroxy-acid dehydratase E4664_06860 ENOG4105DDW LysR family Transcriptional regulator E4664_06865 ENOG4105EXW epimerase dehydratase E4664_06875 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E4664_06890 ENOG4105EHG Permease protein E4664_06895 ENOG4105E0A ABC, transporter E4664_06915 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E4664_06965 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) E4664_07020 ENOG4105E0F Histidine kinase E4664_07045 ENOG4105X0I Fimbrial E4664_07095 ENOG4107RZC phospholipase d E4664_07115 ENOG4108IGT Dipeptidase E4664_07150 ENOG4107T31 5'-nucleotidase E4664_07160 ENOG4105WQI isochorismatase E4664_07165 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase E4664_07170 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) E4664_07175 ENOG4105E0C molybdate abc transporter E4664_07180 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein E4664_07185 ENOG4105F4R Transcriptional regulator mode E4664_07190 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit E4664_07195 ENOG4108YS2 small subunit E4664_07200 ENOG4105F57 Anthranilate dioxygenase reductase E4664_07245 ENOG4105D2S major facilitator superfamily E4664_07250 ENOG4105CF7 AraC family transcriptional regulator E4664_07255 ENOG4105DTD Dehydrogenase E4664_07260 ENOG4105CY2 Citrate transporter E4664_07270 ENOG4108M0I Transcriptional regulator E4664_07285 ENOG4105CRW Short chain fatty acid transporter E4664_07290 ENOG4105CHU acetyl-coa acetyltransferase E4664_07300 ENOG4107YNJ LysR family Transcriptional regulator E4664_07315 ENOG4108IJ0 Aspartate ammonia-lyase E4664_07325 ENOG4105CSH Transporter E4664_07345 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E4664_07350 ENOG4106FTQ Taurine ABC transporter, periplasmic E4664_07365 ENOG4105FDP GntR family transcriptional regulator E4664_07375 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) E4664_07380 ENOG4105KVH Transcriptional regulator E4664_07385 ENOG4105UEI Transcriptional Regulator AraC Family E4664_07400 ENOG4108VCT Sulfite exporter TauE/SafE E4664_07410 ENOG4107S76 domain protein E4664_07420 ENOG4105FFC UPF0187 protein E4664_07430 ENOG4105CHR reductase E4664_07445 ENOG4105CPP Dehydrogenase, E1 component E4664_07450 ENOG4107R0V Pyruvate dehydrogenase E4664_07455 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) E4664_07470 ENOG4105BZU Histidine kinase E4664_07480 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) E4664_07485 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) E4664_07530 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) E4664_07545 ENOG4105C28 cystathionine E4664_07555 ENOG4105F2W methyltransferase E4664_07585 ENOG4105K59 histidine triad (HIT) protein E4664_07610 ENOG4107QWP ABC-2 type transporter E4664_07615 ENOG4107QWP ABC-2 type transporter E4664_07620 ENOG4105CJ1 ABC, transporter E4664_07635 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) E4664_07640 ENOG4105CNM Receptor E4664_07670 ENOG4107TSN permease E4664_07675 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) E4664_07690 ENOG4107TB6 phosphoglycerate mutase E4664_07695 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) E4664_07700 ENOG4108YZT Adenosylcobinamide kinase E4664_07710 ENOG4107VXZ Hydrolase E4664_07745 ENOG4105JSC dimethylmenaquinone methyltransferase E4664_07755 ENOG4105DJU Siderophore biosynthesis protein E4664_07760 ENOG4105DUU IucA IucC family protein E4664_07765 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4664_07780 ENOG4108Z66 YbaK ebsC protein E4664_07795 ENOG4105C1G acyl-Coa dehydrogenase E4664_07800 ENOG4105C1G acyl-Coa dehydrogenase E4664_07805 ENOG4105EEF Alkane 1-monooxygenase E4664_07810 ENOG4105E7U AraC family transcriptional regulator E4664_07815 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) E4664_07820 ENOG4105K70 DNA-binding protein E4664_07835 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family E4664_07845 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins E4664_07850 ENOG4108Z4V iron-sulfur cluster assembly E4664_07865 ENOG4108ZIT Ferredoxin, 2FE-2S E4664_07870 ENOG4105F8J Adenylate Guanylate cyclase E4664_07880 ENOG4108JA2 transcriptioN-repair coupling factor E4664_07900 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) E4664_07905 ENOG4105K4T epimerase E4664_07920 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase E4664_07950 ENOG4105DGW oligopeptidase A E4664_07955 ENOG4107QSI ABC, transporter E4664_07990 ENOG4105SG9 biopolymer transport protein, ExbD E4664_08000 ENOG4107QP3 malate synthase g E4664_08055 ENOG4105E4C Lytic transglycosylase catalytic E4664_08195 ENOG4105CDU Replicative dna helicase E4664_08265 ENOG4105D6Z AFG1 family ATPase E4664_08275 ENOG4107RN6 Monooxygenase E4664_08295 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) E4664_08300 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) E4664_08315 ENOG4108Z6B deaminase E4664_08335 ENOG4108RTD type II secretion system protein K E4664_08360 ENOG4105F8V Hydrolase, tatD family E4664_08370 ENOG4107QRG dna polymerase iii E4664_08380 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) E4664_08385 ENOG4105BZ1 (ABC) transporter E4664_08400 ENOG4105FA0 parb-like partition protein E4664_08405 ENOG4107QJE Chromosome Partitioning Protein E4664_08415 ENOG4108S0S Nucleotidyl transferase E4664_08420 ENOG4105EHM Aminoglycoside phosphotransferase E4664_08425 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) E4664_08430 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) E4664_08435 ENOG4105D2N Aldolase E4664_08455 ENOG4108UHJ MAF-like protein E4664_08460 ENOG4105EZE Cupin 4 family protein E4664_08470 ENOG41080HT Transcriptional regulator, arsr family E4664_08480 ENOG4105XPP Protein of unknown function (DUF1275) E4664_08485 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme E4664_08495 ENOG4105BZ1 (ABC) transporter E4664_08505 ENOG4108ZX5 transcriptional regulator E4664_08515 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) E4664_08520 ENOG4105CK7 Sodium proline symporter E4664_08525 ENOG4105EW9 transcriptional regulator AsnC family E4664_08530 ENOG4105C26 Dehydrogenase E4664_08535 ENOG4105YGK Pfam:UPF0157 E4664_08550 ENOG4108T58 Mg2 transport protein CorA E4664_08560 ENOG4108YYC ycei family E4664_08570 ENOG4105CV1 Transketolase (EC 2.2.1.1) E4664_08595 ENOG4108HWY Beta-lactamase E4664_08615 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) E4664_08620 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) E4664_08640 ENOG4105X0I Fimbrial E4664_08645 ENOG4105GQR Chaperone E4664_08675 ENOG4105ETS cytosine purines uracil thiamine allantoin E4664_08685 ENOG4105CC0 LysR family Transcriptional regulator E4664_08705 ENOG41067SE Tetr family transcriptional regulator E4664_08720 ENOG4105EW9 transcriptional regulator AsnC family E4664_08730 ENOG4105CDA abc transporter atp-binding protein E4664_08735 ENOG4105DRP amino acid AbC transporter E4664_08740 ENOG4105EAD ABC transporter E4664_08755 ENOG4107T8P acyl-Coa dehydrogenase E4664_08770 ENOG4105D01 (LipO)protein E4664_08775 ENOG4105D01 (LipO)protein E4664_08780 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) E4664_08785 ENOG4108UMI ABC transporter, permease E4664_08790 ENOG4105C3G gtp-binding protein E4664_08815 ENOG4108UMN azlc family E4664_08820 ENOG4105ZED uncharacterized protein ygaH E4664_08860 ENOG4105E5H Transposase E4664_08870 ENOG4105E7U AraC family transcriptional regulator E4664_08875 ENOG4108V06 Glutathione peroxidase E4664_08885 ENOG4105CHM Aminotransferase E4664_08890 ENOG4105CK2 sodium dicarboxylate symporter E4664_08900 ENOG4105C0B DNA polymerase III (alpha subunit) E4664_08940 ENOG4108KB2 LysR family Transcriptional regulator E4664_08945 ENOG4105D6J arsenicaL-resistance protein E4664_08950 ENOG41082YX Transcriptional regulator, arsr family E4664_08965 ENOG4105CPN adenine deaminase E4664_08975 ENOG4105CBN LysR family transcriptional regulator E4664_08985 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease E4664_08995 ENOG4105E2B Taurine dioxygenase E4664_09000 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component E4664_09005 ENOG4108IY8 ABC, transporter E4664_09010 ENOG4106FTQ Taurine ABC transporter, periplasmic E4664_09020 ENOG4105C54 Major Facilitator superfamily E4664_09045 ENOG4105C4M (Ubiquinol oxidase) subunit I E4664_09050 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii E4664_09060 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4664_09065 ENOG4108K70 Transcriptional regulator E4664_09080 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E4664_09085 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase E4664_09105 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase E4664_09115 ENOG4105DXI Major Facilitator superfamily E4664_09130 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4664_09135 ENOG41067MG lrgb family E4664_09140 ENOG4105VAW lrga family E4664_09145 ENOG4105CMU LysR family (Transcriptional regulator E4664_09150 ENOG4108SHQ Glutathione S-transferase E4664_09155 ENOG4105CYM Glutathione S-transferase E4664_09160 ENOG4105CBN LysR family transcriptional regulator E4664_09165 ENOG4105CHR reductase E4664_09175 ENOG4105D7W serine acetyltransferase E4664_09180 ENOG4105ESN nucleotide-binding protein E4664_09185 ENOG4105C9B Cysteine desulfurase E4664_09200 ENOG4105EXG Transcriptional regulator E4664_09205 ENOG4105CT1 (ABC) transporter E4664_09210 ENOG4107RP9 extracellular solute-binding protein, family 3 E4664_09215 ENOG4105CDA abc transporter atp-binding protein E4664_09220 ENOG4108HW4 amino acid AbC transporter E4664_09225 ENOG4105EAD ABC transporter E4664_09240 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase E4664_09245 ENOG4105BZU Histidine kinase E4664_09255 ENOG4105EW9 transcriptional regulator AsnC family E4664_09265 ENOG4105KT5 UmuD protein E4664_09285 ENOG4105CYX Short-chain dehydrogenase reductase Sdr E4664_09330 ENOG4105HEI LysR family (Transcriptional regulator E4664_09355 ENOG4105CEY Amp-dependent synthetase and ligase E4664_09360 ENOG4105R8C Transcriptional regulator E4664_09365 ENOG4105C1G acyl-Coa dehydrogenase E4664_09370 ENOG4107QX3 carboxylase E4664_09375 ENOG4105E39 Enoyl-CoA hydratase E4664_09390 ENOG4105CC0 LysR family Transcriptional regulator E4664_09405 ENOG4105CSU acyl-Coa dehydrogenase E4664_09415 ENOG4105EQ0 Major Facilitator superfamily E4664_09425 ENOG4107QNJ CoA-transferase subunit B E4664_09430 ENOG4107QP7 CoA-transferase subunit A E4664_09435 ENOG4107RGD Major Facilitator superfamily E4664_09440 ENOG4105C1G acyl-Coa dehydrogenase E4664_09445 ENOG4105E39 Enoyl-CoA hydratase E4664_09450 ENOG4108R85 Short chain dehydrogenase E4664_09455 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E4664_09460 ENOG4105CHU acetyl-coa acetyltransferase E4664_09470 ENOG4105EQ0 Major Facilitator superfamily E4664_09475 ENOG4105EA8 2-Nitropropane dioxygenase E4664_09480 ENOG4108UKI Enoyl-CoA hydratase E4664_09495 ENOG4105C1G acyl-Coa dehydrogenase E4664_09500 ENOG4107RGD Major Facilitator superfamily E4664_09505 ENOG4108KAZ Involved in phosphonate degradation (By similarity) E4664_09510 ENOG4107STF Involved in phosphonate degradation (By similarity) E4664_09520 ENOG4107RCV ABC transporter, permease E4664_09525 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) E4664_09530 ENOG4105C4Y ABC transporter E4664_09545 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase E4664_09550 ENOG4107HP6 Transcriptional regulator E4664_09560 ENOG4105HEI LysR family (Transcriptional regulator E4664_09565 ENOG4105CPW cytochrome b561 E4664_09570 ENOG4107VGR Catalase E4664_09605 ENOG4108TGR phosphatase E4664_09625 ENOG4107YAU phenylacetic acid degradation protein E4664_09635 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein E4664_09640 ENOG4105DZS Phenylacetate-CoA ligase E4664_09645 ENOG4105CHU acetyl-coa acetyltransferase E4664_09650 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase E4664_09655 ENOG4108UKI Enoyl-CoA hydratase E4664_09660 ENOG4105E39 Enoyl-CoA hydratase E4664_09665 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) E4664_09670 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit E4664_09675 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit E4664_09680 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit E4664_09685 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit E4664_09690 ENOG4105DXM phenylacetic acid degradation protein E4664_09695 ENOG4105EJQ L-serine dehydratase E4664_09700 ENOG4107QTZ amino acid E4664_09705 ENOG4105CZJ Aldehyde dehydrogenase E4664_09750 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4664_09765 ENOG4108Z4X TRANSCRIPTIONal E4664_09775 ENOG4105WPN DNA integration recombination invertion protein E4664_09790 ENOG4105DJ2 Major Facilitator Superfamily E4664_09795 ENOG4107Y2X deaminase E4664_09805 ENOG4105EMY transcriptional regulator E4664_09835 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E4664_09845 ENOG4105UYK outer membrane protein a E4664_09965 ENOG4108HW3 (ABC) transporter E4664_09975 ENOG4105MRR Transcriptional regulator (By similarity) E4664_09995 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF E4664_10025 ENOG4105R8C Transcriptional regulator E4664_10040 ENOG4107R4J Chloride channel E4664_10045 ENOG4108JIK carboxylase E4664_10065 ENOG4105C5A transporter E4664_10070 ENOG4108WAV Transcriptional regulator E4664_10100 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) E4664_10120 ENOG4105D2S major facilitator superfamily E4664_10135 ENOG4105D1S lipid A biosynthesis E4664_10140 ENOG4105BZU Histidine kinase E4664_10145 ENOG4107AQZ Membrane E4664_10165 ENOG4108Z4U Ferredoxin E4664_10210 ENOG4108IUZ ABC transporter E4664_10215 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA E4664_10225 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase E4664_10230 ENOG4105C2X Arabinose 5-phosphate isomerase E4664_10270 ENOG4107YPT transcriptional regulator E4664_10305 ENOG4105II7 pyrroline-5-carboxylate reductase E4664_10315 ENOG4105VEQ Cold shock protein E4664_10320 ENOG410829K Lysine exporter protein (Lyse ygga) E4664_10350 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E4664_10405 ENOG4108KB2 LysR family Transcriptional regulator E4664_10410 ENOG4105FUY alpha subunit E4664_10415 ENOG4108UKV benzoate 1,2-dioxygenase E4664_10420 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein E4664_10425 ENOG4107SEV 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase E4664_10430 ENOG4105DKK Benzoate E4664_10435 ENOG4105D2S major facilitator superfamily E4664_10450 ENOG4105CQ7 ATP-dependent helicase E4664_10455 ENOG4105D3R alkyl hydroperoxide reductase E4664_10465 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) E4664_10475 ENOG4108JU3 Alkyl hydroperoxide reductase E4664_10485 ENOG4108K3A Glutathione S-transferase E4664_10495 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) E4664_10515 ENOG4108TGY Glutathione S-transferase E4664_10525 ENOG4108ZG0 Ompa motb domain protein E4664_10530 ENOG4105CD3 dihydroorotase E4664_10560 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit E4664_10580 ENOG4108UKZ OsmC family E4664_10585 ENOG4107RYR Transcriptional regulator, Crp Fnr family E4664_10590 ENOG4105CPC Aldo Keto reductase E4664_10605 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis E4664_10615 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase E4664_10625 ENOG4105DFP Integrase E4664_10670 ENOG4105NVB glycoside hydrolase, family 19 E4664_10945 ENOG4105CFH Aspartokinase E4664_10955 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) E4664_10965 ENOG4105CPW cytochrome b561 E4664_10970 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) E4664_10975 ENOG4105C7N Xanthine uracil vitamin C permease E4664_10985 ENOG4105F95 Monooxygenase E4664_11020 ENOG4105F95 Monooxygenase E4664_11025 ENOG4105JQZ Methyltransferase E4664_11035 ENOG4107RN6 Monooxygenase E4664_11055 ENOG4105EPF Outer membrane porin E4664_11060 ENOG4105D2S major facilitator superfamily E4664_11065 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E4664_11085 ENOG4105E3J oxidoreductase E4664_11100 ENOG4108SC4 )-transporter E4664_11105 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase E4664_11120 ENOG4105C1G acyl-Coa dehydrogenase E4664_11125 ENOG4105EPF Outer membrane porin E4664_11130 ENOG4105NI3 Protein of unknown function (DUF3237) E4664_11145 ENOG4105JXH GntR family transcriptional regulator E4664_11150 ENOG4105CZJ Aldehyde dehydrogenase E4664_11160 ENOG4105EQX glucarate dehydratase E4664_11165 ENOG4105DJB Major Facilitator Superfamily E4664_11170 ENOG4105CTX dehydratase E4664_11175 ENOG4105DJP Membrane E4664_11180 ENOG4108ZX5 transcriptional regulator E4664_11185 ENOG4107RGH Aldehyde dehydrogenase E4664_11200 ENOG4105C85 amino acid E4664_11220 ENOG4105C26 Dehydrogenase E4664_11240 ENOG4105CUB amino acid E4664_11250 ENOG4105C85 amino acid E4664_11280 ENOG4105D01 (LipO)protein E4664_11290 ENOG4108M3P Membrane E4664_11335 ENOG4105C9U ATP-dependent DNA helicase RecQ E4664_11460 ENOG4105DFP Integrase E4664_11470 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4664_11490 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) E4664_11510 ENOG4108JQ5 ABC transporter E4664_11515 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component E4664_11520 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component E4664_11530 ENOG4105E9H Lytic Murein transglycosylase E4664_11535 ENOG4107RZZ dna polymerase iii epsilon subunit E4664_11545 ENOG4105E09 nadh pyrophosphatase E4664_11555 ENOG4105W4M Transport-associated protein E4664_11565 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) E4664_11575 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) E4664_11580 ENOG4108ZUB Lysine exporter protein (Lyse ygga) E4664_11600 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family E4664_11605 ENOG4105D0A hydroxylase E4664_11760 ENOG41067QW Transcriptional regulator E4664_11815 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase E4664_11835 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b E4664_11845 ENOG4105D82 Glutamate dehydrogenase E4664_11850 ENOG4108R3D Electron transport complex E4664_11855 ENOG4105CSM endonuclease III E4664_11880 ENOG4105CJN penicillin-binding protein E4664_11885 ENOG4106H78 methyltransferase E4664_11900 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) E4664_11910 ENOG4105CQM Urea amidohydrolase subunit alpha E4664_11940 ENOG4107RET Isocitrate lyase E4664_11950 ENOG4105C37 (CBS) domain E4664_11960 ENOG4105D4T Citrate transporter E4664_11975 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) E4664_11990 ENOG4108MRJ E4664_12010 ENOG4105VCQ rubredoxin E4664_12015 ENOG4107QZF nitrite reductase NADPH large subunit E4664_12025 ENOG4105C5Q Transcriptional regulator E4664_12065 ENOG4105CV6 ABC transporter, permease E4664_12070 ENOG4108I0Y (ABC) transporter E4664_12075 ENOG4108UJV acyl-CoA thioesterase i E4664_12095 ENOG4107RNH Outer membrane receptor FepA E4664_12110 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) E4664_12115 ENOG4105E6M Sulphatase-modifying factor protein E4664_12135 ENOG4105CJ3 phosphate transporter E4664_12140 ENOG4105C3R Methionine synthase E4664_12175 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) E4664_12180 ENOG4105EU0 Major facilitator Superfamily E4664_12185 ENOG4108R6W Transcriptional regulator, ARAC family E4664_12190 ENOG4105CSV Glutaminase E4664_12195 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) E4664_12200 ENOG4105CSH Transporter E4664_12210 ENOG4105C7K acetolactate synthase E4664_12225 ENOG4105CHR reductase E4664_12230 ENOG4108MXF Alpha Beta Hydrolase E4664_12240 ENOG4105DJB Major Facilitator Superfamily E4664_12255 ENOG4105CHR reductase E4664_12275 ENOG41069M3 Transcriptional regulator E4664_12290 ENOG4106YT9 Enoyl-CoA hydratase E4664_12300 ENOG4105CND Glycosyl transferase, family 2 E4664_12305 ENOG4107BJW polysaccharide deacetylase E4664_12315 ENOG4108VWS Yaeq family E4664_12325 ENOG4105CKI cobalamin synthesis protein E4664_12345 ENOG4105C94 Transporter E4664_12350 ENOG4105C94 Transporter E4664_12355 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) E4664_12380 ENOG4107QK5 Homocysteine s-methyltransferase E4664_12385 ENOG4105D5Q Arginine ornithine antiporter E4664_12410 ENOG4108YNN Heme oxygenase E4664_12440 ENOG4108SF5 RNA Polymerase E4664_12450 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4664_12455 ENOG4105C54 Major Facilitator superfamily E4664_12485 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) E4664_12490 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4664_12495 ENOG4105CW7 secretion protein, HlyD family E4664_12500 ENOG4108VUY thioesterase Superfamily protein E4664_12505 ENOG4105D52 delta-aminolevulinic acid dehydratase E4664_12510 ENOG4105MWK D-amino acid dehydrogenase, small subunit E4664_12515 ENOG4105ECP epimerase E4664_12535 ENOG4107RH8 nuclease SbcCD subunit D E4664_12540 ENOG4105EYH Exonuclease E4664_12545 ENOG4105DFA alanine racemase domain protein E4664_12550 ENOG4105CZX twitching motility protein E4664_12555 ENOG4105CZX twitching motility protein E4664_12560 ENOG41090R7 Ferric uptake E4664_12590 ENOG4105E7A Glutamine amidotransferase E4664_12605 ENOG4107QKV phosphomannomutase E4664_12615 ENOG4105C4R Atp-dependent dna helicase E4664_12620 ENOG4108ZG0 Ompa motb domain protein E4664_12625 ENOG4106HNH Acyl-transferase E4664_12640 ENOG4107QMS site-determining protein E4664_12660 ENOG4105CNU cell division protein FtsK E4664_12665 ENOG4105C3M thioredoxin reductase E4664_12670 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) E4664_12680 ENOG4105KEG ribosomal-protein-alanine acetyltransferase E4664_12725 ENOG4108YXA Membrane E4664_12730 ENOG4105EUB pirin domain protein E4664_12740 ENOG4105C4K Nad synthetase E4664_12755 ENOG4105E3J oxidoreductase E4664_12760 ENOG4105C26 Dehydrogenase E4664_12765 ENOG4105DVW rieske (2Fe-2S) E4664_12785 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding E4664_12805 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase E4664_12810 ENOG4105C34 Pseudouridine synthase E4664_12815 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane E4664_12820 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) E4664_12835 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) E4664_12865 ENOG4105C5T Phosphoribosyl pyrophosphate synthase E4664_12895 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) E4664_12905 ENOG4105DWF phosphomethylpyrimidine kinase E4664_12910 ENOG4109066 lysm domain bon superfamily protein E4664_12920 ENOG4105CHR reductase E4664_12925 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase E4664_12935 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein E4664_12940 ENOG4108BPE -transporting atpase E4664_12945 ENOG4107RTD sua5 ycio yrdc ywlc family protein E4664_12950 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) E4664_12955 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) E4664_12960 ENOG4105FE9 pseudouridine synthase E4664_12970 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E4664_12975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) E4664_12985 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) E4664_12990 ENOG4108K4C ec 3.1.3.12 E4664_12995 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase E4664_13000 ENOG4106UW1 Major Facilitator superfamily E4664_13020 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) E4664_13030 ENOG4105HF0 Membrane E4664_13045 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY E4664_13055 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) E4664_13115 ENOG4105D1F ATP-binding protein E4664_13125 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) E4664_13155 ENOG4105K6H D-cysteine desulfhydrase E4664_13160 ENOG4105CBX hi0933 family E4664_13185 ENOG4105DP0 ferredoxin-NADP reductase E4664_13190 ENOG4105DUM transcriptional regulator, lysR family E4664_13210 ENOG4105C8S subunit m E4664_13215 ENOG4105D65 subunit l E4664_13225 ENOG4107UFS subunit j E4664_13240 ENOG4108IEH NADH dehydrogenase subunit g E4664_13245 ENOG4107QIZ NADH dehydrogenase E4664_13250 ENOG4105GKE subunit e E4664_13270 ENOG4105BZU Histidine kinase E4664_13280 ENOG4105E0F Histidine kinase E4664_13285 ENOG4107EXC regulatoR E4664_13295 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E4664_13305 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) E4664_13325 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) E4664_13330 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) E4664_13340 ENOG4105ETT transcriptional Regulator, LysR family E4664_13370 ENOG4106P55 Transcriptional regulator E4664_13390 ENOG4106P55 Transcriptional regulator E4664_13395 ENOG4107EFR Flavocytochrome c E4664_13405 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F E4664_13410 ENOG4107RGD Major Facilitator superfamily E4664_13415 ENOG4105C1G acyl-Coa dehydrogenase E4664_13420 ENOG4105ETT transcriptional Regulator, LysR family E4664_13455 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) E4664_13460 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) E4664_13465 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E4664_13485 ENOG4105E3B Multicopper oxidase E4664_13495 ENOG4108HCJ Hydrolase E4664_13500 ENOG4105DJV ribulose-phosphate 3-epimerase E4664_13510 ENOG4105C4W S-formylglutathione hydrolase E4664_13525 ENOG41072GX Peptidase M22 Glycoprotease E4664_13530 ENOG4108Z0R Transferase E4664_13560 ENOG4105CRQ synthase (Component I) E4664_13570 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) E4664_13575 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) E4664_13580 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) E4664_13650 ENOG4105K56 Transcriptional regulator E4664_13655 ENOG4108ZHJ Organic hydroperoxide resistance protein E4664_13660 ENOG4107QHF type ii secretion system protein e E4664_13680 ENOG4105C2M dna polymerase I E4664_13685 ENOG4108VIA integral membrane protein E4664_13690 ENOG4105II7 pyrroline-5-carboxylate reductase E4664_13695 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) E4664_13705 ENOG4105C9X ppx gppa phosphatase E4664_13715 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) E4664_13735 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) E4664_13760 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) E4664_13775 ENOG4105W39 Membrane E4664_13780 ENOG4105CYM Glutathione S-transferase E4664_13800 ENOG4105CEY Amp-dependent synthetase and ligase E4664_13805 ENOG4105N42 UPF0307 protein E4664_13810 ENOG41080Z8 PHOSPHOCARRIER protein E4664_13830 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase E4664_13835 ENOG4105DJ0 Poly(A) Polymerase E4664_13840 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein E4664_13845 ENOG4105DXN mazG family E4664_13855 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E4664_13870 ENOG4105C6T cysteine synthase E4664_13875 ENOG4105BZU Histidine kinase E4664_13880 ENOG4108D7R p-hydroxycinnamoyl CoA hydratase lyase E4664_13885 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E4664_13890 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) E4664_13905 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E4664_13910 ENOG4105W8H transhydrogenase (subunit alpha E4664_13915 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) E4664_13920 ENOG4106UX7 integral membrane protein E4664_13935 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) E4664_13945 ENOG4107RSM transcriptional regulator E4664_13955 ENOG4105CUZ uba thif-type nad fad binding protein E4664_13960 ENOG4107QM5 aconitate hydratase E4664_13965 ENOG4105F8V Hydrolase, tatD family E4664_13980 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) E4664_13995 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium E4664_14005 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein E4664_14010 ENOG4108WUH Transcriptional regulator, TetR family E4664_14020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4664_14030 ENOG4108I6A alcohol dehydrogenase E4664_14045 ENOG4105C4W S-formylglutathione hydrolase E4664_14060 ENOG4108JA1 polyketide synthase E4664_14065 ENOG4107QPD alcohol dehydrogenase E4664_14070 ENOG410810E transcriptional regulator, lysR family E4664_14075 ENOG4105EMU Dehydrogenase E4664_14125 ENOG4105BZU Histidine kinase E4664_14135 ENOG4108ZP8 Acetolactate synthase small subunit E4664_14140 ENOG4105C7K acetolactate synthase E4664_14165 ENOG4105DJY efflux transporter, rnd family, mfp subunit E4664_14170 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) E4664_14175 ENOG4105ENJ RND efflux system, outer membrane lipoprotein E4664_14180 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH E4664_14190 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) E4664_14195 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) E4664_14205 ENOG4105VW4 glutaredoxin 3 E4664_14245 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) E4664_14265 ENOG4105WVQ Fe-S assembly protein IscX E4664_14280 ENOG4105CN1 protease E4664_14295 ENOG4106HB6 Alpha beta hydrolase E4664_14305 ENOG4105C26 Dehydrogenase E4664_14310 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family E4664_14315 ENOG4105C6Z Gluconate E4664_14320 ENOG4108UHU Aldolase E4664_14325 ENOG4105C01 Dihydroxy-acid dehydratase E4664_14330 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) E4664_14335 ENOG4108DNC Involved in acetate metabolism (By similarity) E4664_14340 ENOG4107GFK fumarate E4664_14360 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) E4664_14370 ENOG4108ESX Receptor E4664_14380 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) E4664_14390 ENOG4105DWV Homoserine O-trans-acetylase E4664_14495 ENOG4105CIY formyltetrahydrofolate deformylase E4664_14505 ENOG4107RGH Aldehyde dehydrogenase E4664_14510 ENOG4105KDC 50s ribosomal protein l28 E4664_14515 ENOG4105W0E 50S ribosomal protein L33 E4664_14520 ENOG4105CKD glutathione-regulated potassium-efflux system protein E4664_14540 ENOG4105VFU Rna-binding protein E4664_14545 ENOG4105C4R Atp-dependent dna helicase E4664_14560 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) E4664_14570 ENOG4105KVH Transcriptional regulator E4664_14580 ENOG41069P5 Protein slyX homolog E4664_14585 ENOG4105C5H ABC transporter E4664_14590 ENOG4105N14 lysine exporter protein LysE YggA E4664_14595 ENOG4105D1S lipid A biosynthesis E4664_14605 ENOG4105CK2 sodium dicarboxylate symporter E4664_14660 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) E4664_14685 ENOG4105DUM transcriptional regulator, lysR family E4664_14710 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase E4664_14725 ENOG4108W5M transcriptional regulator E4664_14740 ENOG4105D29 Helix-turn-helix type 11 domain protein E4664_14745 ENOG4107XGZ Hydrolase E4664_14750 ENOG4105EI2 Pseudouridine synthase E4664_14760 ENOG4105C03 ribonuclease E4664_14780 ENOG4105CBN LysR family transcriptional regulator E4664_14785 ENOG4105EMU Dehydrogenase E4664_14790 ENOG4105CSA Coproporphyrinogen iii oxidase E4664_14800 ENOG4107QI1 Mate efflux family protein E4664_14810 ENOG4107T8P acyl-Coa dehydrogenase E4664_14845 ENOG4105BZ8 glutamate synthase E4664_14855 ENOG4108BEW Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) E4664_14860 ENOG4105C5X domain protein E4664_14875 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) E4664_14885 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase E4664_14895 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) E4664_14900 ENOG4108JU5 Magnesium and cobalt efflux protein E4664_14905 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) E4664_14910 ENOG4108Z7R Chaperone CsaA E4664_14920 ENOG4108VAU general secretion pathway protein G E4664_14925 ENOG4105D7Q type ii secretion system E4664_14930 ENOG4105C25 Primosomal protein n' E4664_14935 ENOG4105CKD glutathione-regulated potassium-efflux system protein E4664_14950 ENOG4105DVC DnaJ domain protein E4664_14955 ENOG4108ZKH Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity) E4664_14960 ENOG4107QUT magnesium and cobalt transport protein CorA E4664_14980 ENOG4107QYX exodeoxyribonuclease v alpha E4664_14985 ENOG4107QKA exodeoxyribonuclease V beta E4664_15000 ENOG4105CSR polyphosphate kinase 2 E4664_15010 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) E4664_15025 ENOG41061H0 Monooxygenase E4664_15045 ENOG4105D65 subunit l E4664_15050 ENOG4108ZE9 Monovalent cation H antiporter subunit C E4664_15055 ENOG4107R4Z monovalent cation h antiporter subunit d E4664_15060 ENOG4105SC1 monovalent cation H antiporter subunit E E4664_15065 ENOG4105W4C monovalent cation H antiporter subunit F E4664_15070 ENOG4105KJM monovalent cation h antiporter subunit g E4664_15085 ENOG4105CHV Transcription elongation factor NusA E4664_15110 ENOG4107EJC Preprotein translocase subunit SecG E4664_15120 ENOG4107QHF type ii secretion system protein e E4664_15135 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) E4664_15145 ENOG4105C2N RNA methyltransferase TrmH family group 3 E4664_15160 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) E4664_15170 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) E4664_15200 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) E4664_15205 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase E4664_15270 ENOG4107ZXU DSBA oxidoreductase E4664_15285 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) E4664_15300 ENOG4105D3Y Na H antiporter E4664_15305 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) E4664_15360 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) E4664_15365 ENOG4105PM1 preprotein translocase subunit SecE E4664_15405 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E4664_15410 ENOG4105TV9 FHA Domain-Containing protein E4664_15415 ENOG4105GVR general secretion pathway protein D E4664_15430 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS E4664_15455 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) E4664_15460 ENOG4108NEV two component transcriptional regulator, LytTR family E4664_15465 ENOG4108HRK Histidine kinase E4664_15480 ENOG4108UTW Plays a role in the regulation of phosphate uptake E4664_15485 ENOG4105DFG type I secretion outer membrane protein E4664_15490 ENOG4108RNG Permease of the drug metabolite transporter E4664_15515 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) E4664_15520 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters E4664_15525 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) E4664_15530 ENOG4105CNI cell division protein FtsW E4664_15545 ENOG4105CE1 Ferrous iron transport protein b E4664_15555 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) E4664_15560 ENOG4105T95 Thiol disulfide interChange protein E4664_15565 ENOG4105D6E homoserine dehydrogenase E4664_15575 ENOG41061WM D-Alanyl-D-Alanine E4664_15585 ENOG4107TUY Histidine kinase E4664_15590 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family E4664_15595 ENOG4105CN1 protease E4664_15600 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) E4664_15605 ENOG4108K5H permease YjgP YjgQ family protein E4664_15645 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) E4664_15655 ENOG4105BZU Histidine kinase E4664_15670 ENOG4105C0P Mg chelatase subunit ChlI E4664_15685 ENOG4108HWY Beta-lactamase E4664_15695 ENOG4105F6A helicase E4664_15710 ENOG4105CHH sulfate transporter E4664_15755 ENOG4105C0P Mg chelatase subunit ChlI E4664_15760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family E4664_15765 ENOG4105FB2 class II Aldolase E4664_15770 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4664_15780 ENOG41090KI Outer membrane porin E4664_15785 ENOG4105F0N pyrophosphate phospho-hydrolase E4664_15800 ENOG4105CEY Amp-dependent synthetase and ligase E4664_15805 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4664_15810 ENOG41079KZ Major Facilitator Superfamily E4664_15815 ENOG4105EN6 Membrane E4664_15820 ENOG4105K5B UPF0225 protein E4664_15825 ENOG4105EE5 Membrane protein terC E4664_15830 ENOG4108URH decarboxylase E4664_15835 ENOG4105C0R drug resistance transporter emrb qaca subfamily E4664_15845 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E4664_15860 ENOG4105CCT upf0313 protein E4664_15880 ENOG4105CS1 NAD(P)H quinone oxidoreductase E4664_15890 ENOG4105C6T cysteine synthase E4664_15925 ENOG4105Y7M Transcriptional regulator, TetR family E4664_15960 ENOG4105C79 DNA protecting protein DprA E4664_15975 ENOG4108IND Tetr family transcriptional regulator E4664_15980 ENOG4107RTG Major Facilitator superfamily E4664_15990 ENOG4108V06 Glutathione peroxidase E4664_16000 ENOG41090VV Protein of unknown function (DUF2846) E4664_16035 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) E4664_16060 ENOG4105FDK ABC transporter E4664_16065 ENOG4105FAV ABC, transporter E4664_16075 ENOG4105EZR dyp-type peroxidase family protein E4664_16085 ENOG4107R1I NAD-dependent malic enzyme E4664_16110 ENOG4105EUB pirin domain protein E4664_16130 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) E4664_16135 ENOG4106MP8 UPF0754 membrane protein E4664_16140 ENOG4108VBZ doxx family E4664_16145 ENOG4105DQR SNARE associated Golgi E4664_16160 ENOG4107QJE Chromosome Partitioning Protein E4664_16170 ENOG4107PSF BolA-like protein E4664_16185 ENOG4105CSH Transporter E4664_16190 ENOG4105E39 Enoyl-CoA hydratase E4664_16195 ENOG4105E39 Enoyl-CoA hydratase E4664_16200 ENOG4105C1G acyl-Coa dehydrogenase E4664_16210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase E4664_16215 ENOG4105C26 Dehydrogenase E4664_16225 ENOG4105C85 amino acid E4664_16230 ENOG4105C85 amino acid E4664_16235 ENOG4105M4H endoribonuclease L-psp E4664_16250 ENOG4105EW9 transcriptional regulator AsnC family E4664_16275 ENOG4105D3G Pseudouridine synthase E4664_16345 ENOG4108I0Z Aconitate hydratase E4664_16350 ENOG4105BZN citrate synthase E4664_16355 ENOG4105CR4 methylisocitrate lyase E4664_16360 ENOG4105DRR Transcriptional regulator, GntR family E4664_16370 ENOG4105CGF Aromatic amino acid aminotransferase E4664_16375 ENOG4105CXG d-lactate dehydrogenase E4664_16385 ENOG41073TP transcriptional regulator E4664_16390 ENOG4105DAA L-lactate E4664_16395 ENOG4107QKV phosphomannomutase E4664_16400 ENOG4105CMR udp-glucose 4-epimerase E4664_16410 ENOG4105C6Y Udp-glucose 6-dehydrogenase E4664_16415 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase E4664_16420 ENOG4105D3Q Sugar transferase E4664_16425 ENOG4107UKG Glycosyl transferase, family 4 E4664_16440 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase E4664_16475 ENOG4105F0R Cytidylyltransferase E4664_16490 ENOG4105D2T synthase E4664_16495 ENOG4107SE4 UDP-N-acetylglucosamine 2-epimerase E4664_16500 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase E4664_16510 ENOG4107QQG Dehydrogenase E4664_16515 ENOG4105DAY polysaccharide export protein E4664_16525 ENOG4105D75 Capsular exopolysaccharide family E4664_16530 ENOG4108V1T peptidylprolyl cis-trans isomerase E4664_16535 ENOG4108V1T peptidylprolyl cis-trans isomerase E4664_16540 ENOG4105CJR Integral membrane protein (MviN E4664_16545 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase E4664_16550 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase E4664_16585 ENOG41062JF Transcriptional regulator E4664_16600 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) E4664_16605 ENOG4105UBK short-chain dehydrogenase reductase E4664_16620 ENOG4107QZM n-acetylglutamate synthase E4664_16625 ENOG4105GVF (ABC) transporter E4664_16630 ENOG4105GVF (ABC) transporter E4664_16635 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) E4664_16640 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component E4664_16645 ENOG4108VM9 ABC, transporter E4664_16650 ENOG4108R86 Transcriptional regulator E4664_16655 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) E4664_16665 ENOG4105DTN riboflavin biosynthesis protein ribF E4664_16670 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) E4664_16680 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase E4664_16720 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) E4664_16775 ENOG4105CVE Lytic murein transglycosylase E4664_16780 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit E4664_16785 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) E4664_16800 ENOG4105DFU Cell wall formation (By similarity) E4664_16810 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase E4664_16815 ENOG4105DU1 integral membrane protein, terc E4664_16825 ENOG4106032 Glutathionylspermidine synthase E4664_16835 ENOG4107QUY Guanine deaminase E4664_16840 ENOG4108UGV hypoxanthine phosphoribosyltransferase E4664_16850 ENOG4105T95 Thiol disulfide interChange protein E4664_16855 ENOG4105PGM cation diffusion facilitator family transporter E4664_16870 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins E4664_16885 ENOG4105VG0 50S ribosomal protein l34 E4664_16895 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) E4664_16905 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4664_16915 ENOG4105DQR SNARE associated Golgi E4664_16920 ENOG4105C5H ABC transporter E4664_16925 ENOG4108821 RND type efflux pump E4664_16930 ENOG4108821 RND type efflux pump E4664_16935 ENOG4108821 RND type efflux pump E4664_16945 ENOG4105D74 hydrolase E4664_16950 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) E4664_16955 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) E4664_17000 ENOG4105C8J )-transporter E4664_17010 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B E4664_17035 ENOG4108W5M transcriptional regulator E4664_17040 ENOG4105C2W permease E4664_17050 ENOG4108IG5 Transcriptional regulator E4664_17055 ENOG4105DJY efflux transporter, rnd family, mfp subunit E4664_17090 ENOG4105F27 Major Facilitator E4664_17095 ENOG4105CV8 reductase E4664_17100 ENOG4105HEI LysR family (Transcriptional regulator E4664_17120 ENOG4105DQ4 alcohol dehydrogenase E4664_17125 ENOG4108R3E Dna-3-methyladenine glycosylase i E4664_17140 ENOG4105CEN a g-specific adenine glycosylase E4664_17160 ENOG4108ZZ3 UPF0260 protein E4664_17170 ENOG4105D1H recombination factor protein RarA E4664_17175 ENOG4105S64 Formate nitrite transporter E4664_17195 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) E4664_17200 ENOG4108RWI nicotinamidase E4664_17205 ENOG4105C09 Bile acid E4664_17210 ENOG4107QI1 Mate efflux family protein E4664_17215 ENOG4105EWC Purine nucleoside phosphorylase E4664_17235 ENOG4108RXX maleylacetoacetate isomerase E4664_17245 ENOG4105C85 amino acid E4664_17255 ENOG4105CKI cobalamin synthesis protein E4664_17265 ENOG4105CZE histidine utilization repressor E4664_17270 ENOG41090B9 response to stress E4664_17285 ENOG4105C85 amino acid E4664_17295 ENOG41088SP formiminoglutamate hydrolase E4664_17310 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) E4664_17375 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) E4664_17385 ENOG4108ZAI phosphatidylglycerophosphatase a E4664_17390 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) E4664_17405 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) E4664_17445 ENOG4105KHC sulfurtransferase E4664_17460 ENOG4105BZU Histidine kinase E4664_17465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E4664_17480 ENOG4107QJQ Mate efflux family protein E4664_17485 ENOG4105CHM Aminotransferase E4664_17490 ENOG4106BRA Membrane E4664_17505 ENOG4105D9M gamma-glutamylcysteine synthetase E4664_17515 ENOG4105CS6 Rhs element vgr protein E4664_17585 ENOG4105IPS esterase E4664_17590 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) E4664_17595 ENOG4105EWI Short-chain dehydrogenase reductase Sdr E4664_17600 ENOG4108Z2U ureidoglycolate hydrolase E4664_17610 ENOG41061H0 Monooxygenase E4664_17625 ENOG41084YZ Hydrolase E4664_17655 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) E4664_17660 ENOG4105BZU Histidine kinase E4664_17675 ENOG4105KUZ arsenate reductase E4664_17680 ENOG4105CGK Exodeoxyribonuclease III E4664_17705 ENOG4105D7Z glutathione synthase E4664_17725 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) E4664_17730 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) E4664_17735 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) E4664_17750 ENOG41063SB peptidase E4664_17755 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) E4664_17760 ENOG4107QSN dihydrolipoamide acetyltransferase E4664_17775 ENOG4105E0K tonB-dependent siderophore receptor E4664_17790 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) E4664_17805 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) E4664_17825 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase E4664_17830 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase E4664_17840 ENOG4105D64 Mechanosensitive ion channel E4664_17850 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) E4664_17855 ENOG4108W2Y isochorismatase E4664_17865 ENOG4105FBW Monooxygenase E4664_17870 ENOG4108UZX fmn reductase E4664_17885 ENOG4105BZU Histidine kinase E4664_17890 ENOG41062QD Membrane E4664_17895 ENOG4107QN1 sodium solute E4664_17905 ENOG4105C94 Transporter E4664_17915 ENOG4105BZU Histidine kinase E4664_17920 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) E4664_17925 ENOG4108WUH Transcriptional regulator, TetR family E4664_17930 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein E4664_17940 ENOG4105RA2 Membrane E4664_17945 ENOG4105DWF phosphomethylpyrimidine kinase E4664_17955 ENOG4107RDB Major Facilitator E4664_17960 ENOG4108UUM single-stranded DNA-binding protein E4664_17980 ENOG4105C85 amino acid E4664_17990 ENOG4108JPW Aminotransferase E4664_17995 ENOG4105C26 Dehydrogenase E4664_18005 ENOG4105CHJ isochorismatase hydrolase E4664_18010 ENOG4105EUB pirin domain protein E4664_18035 ENOG4105D94 Major Facilitator Superfamily E4664_18040 ENOG4106NZI LysR family Transcriptional regulator E4664_18090 ENOG4105CPC Aldo Keto reductase E4664_18115 ENOG4105C2J ABC transporter E4664_18125 ENOG4108UQN AraC family transcriptional regulator E4664_18180 ENOG4105CUV Homoserine Kinase E4664_18195 ENOG41061CK Antibiotic biosynthesis monooxygenase E4664_18210 ENOG4105BZ1 (ABC) transporter E4664_18230 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) E4664_18260 ENOG4105CYC Transferase E4664_18270 ENOG4105E0F Histidine kinase E4664_18275 ENOG4105DPZ Two component transcriptional regulator (Winged helix family E4664_18285 ENOG4105CHH sulfate transporter E4664_18290 ENOG4105PDP Short chain dehydrogenase E4664_18300 ENOG4105C5H ABC transporter E4664_18365 ENOG4108IQI permease E4664_18390 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein E4664_18405 ENOG4105CJN penicillin-binding protein E4664_18410 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) E4664_18415 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) E4664_18430 ENOG4105DHI Methyltransferase E4664_18435 ENOG4108JQC penicillin-binding protein 1A E4664_18460 ENOG4105E4G Type IV pilus E4664_18485 ENOG4105BZ8 glutamate synthase E4664_18495 ENOG4108V0P LemA family E4664_18500 ENOG4105HA9 of methanol dehydrogenase type E4664_18520 ENOG4108YSG O-Antigen polymerase E4664_18525 ENOG4108UQY Iron-storage protein E4664_18535 ENOG4105KME endoribonuclease L-psp E4664_18540 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) E4664_18555 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) E4664_18605 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) E4664_18620 ENOG4107IFA Lipase (EC 3.1.1.3) E4664_18625 ENOG4105MGK May be involved in the folding of the extracellular lipase during its passage through the periplasm (By similarity) E4664_18630 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) E4664_18655 ENOG4108JQ1 Dehydrogenase E4664_18660 ENOG4105CQB FAD linked oxidase domain protein E4664_18670 ENOG4105VRH Antibiotic biosynthesis monooxygenase E4664_18675 ENOG4105NF4 modulator of drug activity E4664_18685 ENOG4107QF7 multi-drug E4664_18690 ENOG4105EM2 membrane E4664_18695 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) E4664_18700 ENOG4105IPI Membrane E4664_18705 ENOG4107SKI cobyrinic Acid a,c-diamide synthase E4664_18735 ENOG4108IQI permease E4664_18740 ENOG4105D82 Glutamate dehydrogenase E4664_18745 ENOG4105C8Y Acetylornithine aminotransferase E4664_18755 ENOG4105C26 Dehydrogenase E4664_18780 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin E4664_18850 ENOG4105W87 Cbs domain E4664_18855 ENOG41067S9 phage shock protein C, PspC E4664_18865 ENOG4105CSU acyl-Coa dehydrogenase E4664_18880 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) E4664_18895 ENOG4105ECY inositol monophosphatase E4664_18900 ENOG4105C1J atp-dependent rna helicase E4664_18910 ENOG4105DHJ ABC, transporter E4664_18915 ENOG4105CY3 ABC transporter, permease E4664_18925 ENOG4105E3I toluene tolerance E4664_18935 ENOG4105D7N magnesium and cobalt transport protein CorA E4664_18940 ENOG4108URH decarboxylase E4664_18950 ENOG4105MJ2 Competence protein E4664_18955 ENOG4105CB5 ATP-dependent DNA helicase recG E4664_18975 ENOG4105C29 acyl-CoA thioesterase E4664_18980 ENOG4105CK2 sodium dicarboxylate symporter E4664_18995 ENOG4105KPV Transcriptional regulator E4664_19005 ENOG4105D7A ATP-binding protein E4664_19010 ENOG4105C28 cystathionine E4664_19015 ENOG41089BK Glutamine amido-transferase E4664_19125 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) E4664_19130 ENOG41067V7 50S ribosomal protein L36 E4664_19140 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) E4664_19165 ENOG4105C1G acyl-Coa dehydrogenase E4664_19200 ENOG4105VKU nucleicacid-binding protein E4664_19205 ENOG4105DGW oligopeptidase A E4664_19210 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) E4664_19255 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase E4664_19260 ENOG4108K2B transcriptional regulator E4664_19270 ENOG4107S2Z UPF0761 membrane protein E4664_19275 ENOG4105CS1 NAD(P)H quinone oxidoreductase E4664_19305 ENOG4105C9A Phoh family E4664_19315 ENOG4105E4C Lytic transglycosylase catalytic E4664_19345 ENOG4105D6S protein involved in catabolism of external DNA E4664_19350 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase E4664_19395 ENOG4105C1G acyl-Coa dehydrogenase E4664_19415 ENOG4105KB2 stringent starvation protein b E4664_19420 ENOG4107MKT Stringent starvation protein a E4664_19425 ENOG4108UJD 30S ribosomal protein S9 E4664_19435 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) E4664_19440 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) E4664_19445 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) E4664_19465 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) E4664_19475 ENOG4107RZC phospholipase d E4664_19485 ENOG4105UYK outer membrane protein a E4664_19490 ENOG4108KHX Diguanylate cyclase E4664_19525 ENOG4107QN2 dihydrolipoyl dehydrogenase E4664_19535 ENOG4107QPB Beta-lactamase domain protein E4664_19540 ENOG4107U2T alpha beta E4664_19550 ENOG4105NAU thioesterase Superfamily protein E4664_19580 ENOG4105K9H YciI-like protein E4664_19590 ENOG4105DB7 PHP domain protein E4664_19595 ENOG4105FFC UPF0187 protein E4664_19605 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase E4664_19610 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E4664_19615 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) E4664_19620 ENOG4105VIE preprotein translocase, subunit YajC E4664_19665 ENOG4108UUM single-stranded DNA-binding protein E4664_19730 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) E4664_19830 ENOG4105YES addiction module antidote protein E4664_19835 ENOG4105VUH addiction module killer protein E4664_19880 ENOG4105IYK transposase E4664_19935 ENOG4105K5B UPF0225 protein E4664_19975 ENOG4107SVC Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) E4664_20010 ENOG4105DZR Type I site-specific deoxyribonuclease E4664_20025 ENOG4105CVR type I restriction-modification system E4664_20040 ENOG4107QJE Chromosome Partitioning Protein E4664_20105 ENOG4105I1F Resistance protein E4664_20165 ENOG4105E4P ATPase (AAA E4664_20215 ENOG4108HWY Beta-lactamase E4664_20230 ENOG4105YES addiction module antidote protein E4664_20290 ENOG4105XUP Phage derived protein Gp49-like (DUF891) E4664_20395 ENOG4105F9F transposase E4664_20405 ENOG4105C1P efflux transporter, rnd family, mfp subunit E4664_20410 ENOG4105BZS acriflavin resistance protein E4664_20420 ENOG4105BZU Histidine kinase E4664_20425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family E4664_20470 ENOG4108NE4 E4664_20485 ENOG4107QJE Chromosome Partitioning Protein